| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | calcium channel activity | 9.14e-06 | 129 | 21 | 4 | GO:0005262 | |
| GeneOntologyMolecularFunction | calcium ion transmembrane transporter activity | 1.70e-05 | 151 | 21 | 4 | GO:0015085 | |
| GeneOntologyMolecularFunction | muscle alpha-actinin binding | 1.10e-04 | 15 | 21 | 2 | GO:0051371 | |
| GeneOntologyMolecularFunction | transporter activity | 2.39e-04 | 1289 | 21 | 7 | GO:0005215 | |
| GeneOntologyMolecularFunction | monoatomic cation channel activity | 4.06e-04 | 343 | 21 | 4 | GO:0005261 | |
| GeneOntologyMolecularFunction | ligand-gated monoatomic cation channel activity | 4.09e-04 | 140 | 21 | 3 | GO:0099094 | |
| GeneOntologyMolecularFunction | alpha-actinin binding | 4.81e-04 | 31 | 21 | 2 | GO:0051393 | |
| GeneOntologyMolecularFunction | actinin binding | 9.27e-04 | 43 | 21 | 2 | GO:0042805 | |
| GeneOntologyMolecularFunction | inorganic molecular entity transmembrane transporter activity | 9.53e-04 | 758 | 21 | 5 | GO:0015318 | |
| GeneOntologyMolecularFunction | ligand-gated monoatomic ion channel activity | 1.04e-03 | 193 | 21 | 3 | GO:0015276 | |
| GeneOntologyMolecularFunction | transmembrane transporter activity | 1.06e-03 | 1180 | 21 | 6 | GO:0022857 | |
| GeneOntologyMolecularFunction | ligand-gated channel activity | 1.10e-03 | 197 | 21 | 3 | GO:0022834 | |
| GeneOntologyMolecularFunction | monoatomic ion channel activity | 1.21e-03 | 459 | 21 | 4 | GO:0005216 | |
| GeneOntologyMolecularFunction | metal ion transmembrane transporter activity | 1.27e-03 | 465 | 21 | 4 | GO:0046873 | |
| GeneOntologyMolecularFunction | hexosyltransferase activity | 1.34e-03 | 211 | 21 | 3 | GO:0016758 | |
| GeneOntologyMolecularFunction | sodium channel activity | 1.35e-03 | 52 | 21 | 2 | GO:0005272 | |
| GeneOntologyMolecularFunction | sulfur compound transmembrane transporter activity | 1.86e-03 | 61 | 21 | 2 | GO:1901682 | |
| GeneOntologyMolecularFunction | channel activity | 1.98e-03 | 525 | 21 | 4 | GO:0015267 | |
| GeneOntologyMolecularFunction | passive transmembrane transporter activity | 1.99e-03 | 526 | 21 | 4 | GO:0022803 | |
| GeneOntologyMolecularFunction | glycosyltransferase activity | 3.26e-03 | 288 | 21 | 3 | GO:0016757 | |
| GeneOntologyMolecularFunction | inorganic cation transmembrane transporter activity | 3.76e-03 | 627 | 21 | 4 | GO:0022890 | |
| GeneOntologyMolecularFunction | monoatomic cation transmembrane transporter activity | 4.62e-03 | 664 | 21 | 4 | GO:0008324 | |
| GeneOntologyMolecularFunction | gated channel activity | 4.93e-03 | 334 | 21 | 3 | GO:0022836 | |
| GeneOntologyMolecularFunction | potassium channel activity | 7.91e-03 | 128 | 21 | 2 | GO:0005267 | |
| GeneOntologyMolecularFunction | monoatomic ion transmembrane transporter activity | 8.61e-03 | 793 | 21 | 4 | GO:0015075 | |
| GeneOntologyMolecularFunction | transmembrane signaling receptor activity | 1.16e-02 | 1353 | 21 | 5 | GO:0004888 | |
| GeneOntologyMolecularFunction | active transmembrane transporter activity | 1.31e-02 | 477 | 21 | 3 | GO:0022804 | |
| GeneOntologyMolecularFunction | potassium ion transmembrane transporter activity | 1.32e-02 | 167 | 21 | 2 | GO:0015079 | |
| GeneOntologyMolecularFunction | sodium ion transmembrane transporter activity | 1.38e-02 | 171 | 21 | 2 | GO:0015081 | |
| GeneOntologyMolecularFunction | transmembrane transporter binding | 1.39e-02 | 172 | 21 | 2 | GO:0044325 | |
| GeneOntologyBiologicalProcess | calcium ion transmembrane transport | 3.83e-05 | 392 | 21 | 5 | GO:0070588 | |
| GeneOntologyBiologicalProcess | detection of mechanical stimulus | 5.86e-05 | 75 | 21 | 3 | GO:0050982 | |
| GeneOntologyBiologicalProcess | response to water | 8.92e-05 | 14 | 21 | 2 | GO:0009415 | |
| GeneOntologyBiologicalProcess | hyaluronan biosynthetic process | 1.17e-04 | 16 | 21 | 2 | GO:0030213 | |
| GeneOntologyBiologicalProcess | calcium ion transport | 1.32e-04 | 509 | 21 | 5 | GO:0006816 | |
| GeneOntologyBiologicalProcess | inorganic cation transmembrane transport | 2.39e-04 | 922 | 21 | 6 | GO:0098662 | |
| GeneOntologyBiologicalProcess | cellular response to fluid shear stress | 2.47e-04 | 23 | 21 | 2 | GO:0071498 | |
| GeneOntologyBiologicalProcess | monoatomic cation transmembrane transport | 2.68e-04 | 942 | 21 | 6 | GO:0098655 | |
| GeneOntologyBiologicalProcess | metal ion transport | 3.70e-04 | 1000 | 21 | 6 | GO:0030001 | |
| GeneOntologyBiologicalProcess | inorganic ion transmembrane transport | 4.05e-04 | 1017 | 21 | 6 | GO:0098660 | |
| GeneOntologyBiologicalProcess | activation of adenylate cyclase activity | 5.43e-04 | 34 | 21 | 2 | GO:0007190 | |
| GeneOntologyBiologicalProcess | response to fluid shear stress | 5.76e-04 | 35 | 21 | 2 | GO:0034405 | |
| GeneOntologyBiologicalProcess | regulation of mitochondrial fission | 6.09e-04 | 36 | 21 | 2 | GO:0090140 | |
| GeneOntologyBiologicalProcess | detection of stimulus | 6.61e-04 | 722 | 21 | 5 | GO:0051606 | |
| GeneOntologyBiologicalProcess | monoatomic ion transmembrane transport | 6.62e-04 | 1115 | 21 | 6 | GO:0034220 | |
| GeneOntologyBiologicalProcess | detection of external stimulus | 6.90e-04 | 173 | 21 | 3 | GO:0009581 | |
| GeneOntologyBiologicalProcess | detection of abiotic stimulus | 7.14e-04 | 175 | 21 | 3 | GO:0009582 | |
| GeneOntologyBiologicalProcess | carbohydrate derivative biosynthetic process | 7.21e-04 | 736 | 21 | 5 | GO:1901137 | |
| GeneOntologyBiologicalProcess | positive regulation of adenylate cyclase activity | 7.52e-04 | 40 | 21 | 2 | GO:0045762 | |
| GeneOntologyBiologicalProcess | hyaluronan metabolic process | 7.52e-04 | 40 | 21 | 2 | GO:0030212 | |
| GeneOntologyBiologicalProcess | monoatomic cation transport | 8.05e-04 | 1157 | 21 | 6 | GO:0006812 | |
| GeneOntologyBiologicalProcess | positive regulation of cyclase activity | 1.08e-03 | 48 | 21 | 2 | GO:0031281 | |
| GeneOntologyBiologicalProcess | positive regulation of lyase activity | 1.13e-03 | 49 | 21 | 2 | GO:0051349 | |
| GeneOntologyBiologicalProcess | mitochondrial fission | 1.22e-03 | 51 | 21 | 2 | GO:0000266 | |
| GeneOntologyCellularComponent | ciliary membrane | 1.44e-04 | 98 | 22 | 3 | GO:0060170 | |
| GeneOntologyCellularComponent | monoatomic ion channel complex | 5.95e-04 | 378 | 22 | 4 | GO:0034702 | |
| GeneOntologyCellularComponent | cell projection membrane | 9.71e-04 | 431 | 22 | 4 | GO:0031253 | |
| GeneOntologyCellularComponent | spindle | 1.35e-03 | 471 | 22 | 4 | GO:0005819 | |
| GeneOntologyCellularComponent | cation channel complex | 1.84e-03 | 235 | 22 | 3 | GO:0034703 | |
| GeneOntologyCellularComponent | transmembrane transporter complex | 1.98e-03 | 523 | 22 | 4 | GO:1902495 | |
| GeneOntologyCellularComponent | transporter complex | 2.38e-03 | 550 | 22 | 4 | GO:1990351 | |
| GeneOntologyCellularComponent | calcium channel complex | 2.66e-03 | 73 | 22 | 2 | GO:0034704 | |
| Domain | PKD_2 | 1.20e-05 | 5 | 21 | 2 | IPR003915 | |
| Domain | PKD1_2_channel | 6.58e-05 | 11 | 21 | 2 | IPR013122 | |
| Domain | PKD_channel | 6.58e-05 | 11 | 21 | 2 | PF08016 | |
| Pathway | REACTOME_HYALURONAN_BIOSYNTHESIS_AND_EXPORT | 1.21e-05 | 5 | 16 | 2 | MM14865 | |
| Pathway | REACTOME_HYALURONAN_BIOSYNTHESIS_AND_EXPORT | 1.21e-05 | 5 | 16 | 2 | M27144 | |
| Pathway | KEGG_MEDICUS_REFERENCE_AVP_V2R_PKA_SIGNALING_PATHWAY | 5.41e-05 | 10 | 16 | 2 | M47648 | |
| Pathway | REACTOME_HYALURONAN_METABOLISM | 1.63e-04 | 17 | 16 | 2 | M666 | |
| Pathway | REACTOME_HYALURONAN_METABOLISM | 1.63e-04 | 17 | 16 | 2 | MM14864 | |
| Pathway | REACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS | 1.06e-03 | 43 | 16 | 2 | M933 | |
| Pathway | KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION | 1.11e-03 | 44 | 16 | 2 | M9011 | |
| Pathway | WP_VASOPRESSINREGULATED_WATER_REABSORPTION | 1.11e-03 | 44 | 16 | 2 | M42554 | |
| Pathway | REACTOME_AQUAPORIN_MEDIATED_TRANSPORT | 1.55e-03 | 52 | 16 | 2 | M920 | |
| Pubmed | 3.82e-07 | 2 | 22 | 2 | 20408813 | ||
| Pubmed | Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels. | 3.82e-07 | 2 | 22 | 2 | 29899465 | |
| Pubmed | Polycystin-2 interacts with troponin I, an angiogenesis inhibitor. | 1.15e-06 | 3 | 22 | 2 | 12525172 | |
| Pubmed | Polycystin-2 expression and function in adult mouse lacrimal acinar cells. | 1.15e-06 | 3 | 22 | 2 | 21508103 | |
| Pubmed | Specific association of the gene product of PKD2 with the TRPC1 channel. | 2.29e-06 | 4 | 22 | 2 | 10097141 | |
| Pubmed | 3.82e-06 | 5 | 22 | 2 | 11698076 | ||
| Pubmed | Troponin I binds polycystin-L and inhibits its calcium-induced channel activation. | 3.82e-06 | 5 | 22 | 2 | 12809519 | |
| Pubmed | Tulp3 Is a Ciliary Trafficking Gene that Regulates Polycystic Kidney Disease. | 5.72e-06 | 6 | 22 | 2 | 30799240 | |
| Pubmed | 1.37e-05 | 9 | 22 | 2 | 18172001 | ||
| Pubmed | 1.71e-05 | 10 | 22 | 2 | 16805797 | ||
| Pubmed | Meta-analysis identifies common variants associated with body mass index in east Asians. | 2.09e-05 | 11 | 22 | 2 | 22344219 | |
| Pubmed | 3.46e-05 | 14 | 22 | 2 | 22442076 | ||
| Pubmed | 3.99e-05 | 15 | 22 | 2 | 28167615 | ||
| Pubmed | Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. | 1.14e-04 | 25 | 22 | 2 | 28154160 | |
| Pubmed | 1.33e-04 | 27 | 22 | 2 | 16460286 | ||
| Pubmed | 1.43e-04 | 28 | 22 | 2 | 24861553 | ||
| Pubmed | 1.99e-04 | 33 | 22 | 2 | 19834762 | ||
| Pubmed | 3.56e-04 | 44 | 22 | 2 | 19322198 | ||
| Pubmed | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. | 6.18e-04 | 58 | 22 | 2 | 20935630 | |
| GeneFamily | Transient receptor potential cation channels | 2.74e-04 | 28 | 16 | 2 | 249 | |
| Disease | polycystic kidney disease 2 (implicated_via_orthology) | 1.18e-06 | 3 | 19 | 2 | DOID:0110859 (implicated_via_orthology) | |
| Disease | autosomal dominant polycystic kidney disease (implicated_via_orthology) | 3.56e-05 | 14 | 19 | 2 | DOID:898 (implicated_via_orthology) | |
| Disease | Benign Neoplasm | 8.72e-04 | 68 | 19 | 2 | C0086692 | |
| Disease | Neoplasms | 8.72e-04 | 68 | 19 | 2 | C0027651 | |
| Disease | bone density | 1.87e-03 | 388 | 19 | 3 | EFO_0003923 | |
| Disease | physical activity measurement, body mass index | 2.42e-03 | 114 | 19 | 2 | EFO_0004340, EFO_0008002 | |
| Disease | smoking behavior, body mass index | 2.81e-03 | 123 | 19 | 2 | EFO_0004318, EFO_0004340 | |
| Disease | Malignant Neoplasms | 3.04e-03 | 128 | 19 | 2 | C0006826 | |
| Disease | Non-Small Cell Lung Carcinoma | 4.48e-03 | 156 | 19 | 2 | C0007131 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| YYMATMTMVTFSTAL | 301 | Q9GZZ6 | |
| LATVEMMASHMYTSY | 701 | Q96BY7 | |
| TAVLMFYGSLMSMYL | 246 | Q8NGM9 | |
| TIKSATISYYQMMHM | 501 | Q92619 | |
| TYGSAMAMYAYFVMT | 271 | Q8NE86 | |
| MAMYAYFVMTRQEYV | 276 | Q8NE86 | |
| EEMKAMLSYYYSTVM | 76 | Q13163 | |
| MYFFISQLSLMDMAY | 91 | Q8NH00 | |
| MQYYASIYALSMAVM | 911 | O15440 | |
| LMSASTYTFMMMWEY | 251 | Q7Z388 | |
| TYTFMMMWEYSHYLL | 256 | Q7Z388 | |
| SMTVMVFLMMLSFYY | 841 | O60266 | |
| MIFMSLYSLLYMSSL | 436 | O00219 | |
| DAYMCMYQSPTMSLY | 941 | Q9NQC7 | |
| VNLSQTYMAMYLTYS | 291 | Q6NUT3 | |
| VAYYTMMMNLYNAMA | 81 | Q96L03 | |
| MYGVTSMYFSAVMVR | 391 | P46977 | |
| MASLMILFMMDQSYY | 171 | A0A1B0GVZ9 | |
| MMFYKSTTISMYLAS | 341 | Q86UB9 | |
| MMSSNVYYYTRMMSQ | 241 | Q13563 | |
| MTSSSAYYYTKVMSE | 121 | Q9P0L9 | |
| STAMMLIYYAYQTMS | 141 | Q2M3R5 | |
| VGMYASSYMILAMTL | 121 | P30518 | |
| QYRQICNMYTMYSMM | 296 | Q96RE7 |