Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF823 ZNF267 ZNF814 ZNF799 ZNF28 ZNF33B ZNF107 ZNF257 RBAK LHX9

2.89e-0414123910GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF823 ZNF267 ZNF814 ZNF799 ZNF28 ZNF33B ZNF107 ZNF257 RBAK LHX9

3.76e-0414593910GO:0000977
DomainKRAB

ZNF823 ZNF267 ZNF814 ZNF799 ZNF28 ZNF33B ZNF738 ZNF257 RBAK

4.03e-08358399PS50805
DomainKRAB

ZNF823 ZNF267 ZNF814 ZNF799 ZNF28 ZNF33B ZNF738 ZNF257 RBAK

4.03e-08358399PF01352
DomainKRAB

ZNF823 ZNF267 ZNF814 ZNF799 ZNF28 ZNF33B ZNF738 ZNF257 RBAK

5.23e-08369399SM00349
DomainKRAB

ZNF823 ZNF267 ZNF814 ZNF799 ZNF28 ZNF33B ZNF738 ZNF257 RBAK

5.35e-08370399IPR001909
Domain-

CPSF4 CPSF4L PAN3 ZC3H7B

1.41e-06403944.10.1000.10
DomainZnF_C3H1

CPSF4 CPSF4L PAN3 ZC3H7B

2.96e-0648394SM00356
DomainZINC_FINGER_C2H2_2

ZNF823 ZNF267 ZNF814 ZNF799 ZNF28 ZNF33B ZC3H7B ZNF107 ZNF257 RBAK

3.04e-067753910PS50157
DomainZINC_FINGER_C2H2_1

ZNF823 ZNF267 ZNF814 ZNF799 ZNF28 ZNF33B ZC3H7B ZNF107 ZNF257 RBAK

3.11e-067773910PS00028
DomainZnf_C2H2-like

ZNF823 ZNF267 ZNF814 ZNF799 ZNF28 ZNF33B ZC3H7B ZNF107 ZNF257 RBAK

3.86e-067963910IPR015880
DomainZnf_C2H2

ZNF823 ZNF267 ZNF814 ZNF799 ZNF28 ZNF33B ZC3H7B ZNF107 ZNF257 RBAK

4.26e-068053910IPR007087
DomainZnF_C2H2

ZNF823 ZNF267 ZNF814 ZNF799 ZNF28 ZNF33B ZC3H7B ZNF107 ZNF257 RBAK

4.41e-068083910SM00355
DomainZnf_CCCH

CPSF4 CPSF4L PAN3 ZC3H7B

6.35e-0658394IPR000571
DomainZF_C3H1

CPSF4 CPSF4L PAN3 ZC3H7B

6.35e-0658394PS50103
Domain-

ZNF823 ZNF267 ZNF814 ZNF799 ZNF28 ZNF33B ZNF107 ZNF257 RBAK

8.38e-066793993.30.160.60
Domainzf-C2H2

ZNF823 ZNF267 ZNF814 ZNF799 ZNF28 ZNF33B ZNF107 ZNF257 RBAK

9.87e-06693399PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF823 ZNF267 ZNF814 ZNF799 ZNF28 ZNF33B ZNF107 ZNF257 RBAK

9.98e-06694399IPR013087
DomainAPC_su10/DOC_dom

ZZEF1 MYCBP2

8.86e-057392IPR004939
DomainAPC10

ZZEF1 MYCBP2

8.86e-057392SM01337
DomainDOC

ZZEF1 MYCBP2

8.86e-057392PS51284
DomainANAPC10

ZZEF1 MYCBP2

8.86e-057392PF03256
Domainzf-CCCH

CPSF4 CPSF4L ZC3H7B

1.45e-0449393PF00642
DomainLIM

FHL2 PDLIM5 LHX9

4.01e-0469393PF00412
Domain-

FHL2 PDLIM5 LHX9

4.18e-04703932.10.110.10
DomainLIM_DOMAIN_2

FHL2 PDLIM5 LHX9

4.36e-0471393PS50023
DomainZnf_LIM

FHL2 PDLIM5 LHX9

4.36e-0471393IPR001781
DomainLIM_DOMAIN_1

FHL2 PDLIM5 LHX9

4.36e-0471393PS00478
DomainLIM

FHL2 PDLIM5 LHX9

4.36e-0471393SM00132
Domainzf-C2H2_6

ZNF823 ZNF267 ZNF814 ZNF799 ZNF107

4.69e-04314395PF13912
DomainSET

SETD2 KMT2E

3.31e-0341392PF00856
DomainSET

SETD2 KMT2E

4.15e-0346392SM00317
DomainSET_dom

SETD2 KMT2E

4.89e-0350392IPR001214
DomainSET

SETD2 KMT2E

4.89e-0350392PS50280
DomainEGF_extracell

HHIP JAG1

6.97e-0360392IPR013111
DomainEGF_2

HHIP JAG1

6.97e-0360392PF07974
Domain-

ZZEF1 MYCBP2

1.02e-02733922.60.120.260
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF267 ZNF799 ZNF33B ZNF107 ZNF738 ZNF257

5.17e-0818139637372979
Pubmed

The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling.

BIRC3 RNF31

7.34e-06439229378181
Pubmed

Hedgehog Interacting Protein Promotes Fibrosis and Apoptosis in Glomerular Endothelial Cells in Murine Diabetes.

HHIP LEPR

7.34e-06439229654303
Pubmed

Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC).

BIRC3 RNF31

1.22e-05539225494483
Pubmed

The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.

BIRC3 RNF31

8.03e-051239222607974
Pubmed

Lhx2 in germ cells suppresses endothelial cell migration in the developing ovary.

JAG1 LHX9

8.03e-051239235337816
Pubmed

--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.

BIRC3 RNF31

9.48e-051339227810922
Pubmed

YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB.

BIRC3 RNF31

1.46e-041639228244869
Pubmed

An essential role for Polycomb Repressive Complex 2 in the mouse ovary.

HHIP JAG1 LHX9

1.84e-049839335084365
Pubmed

Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.

BIRC3 RNF31

1.85e-041839232968279
Pubmed

Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development.

JAG1 LHX9

2.30e-042039216169709
Pubmed

Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development.

HHIP JAG1

2.54e-042139228794157
Pubmed

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.

GPRC6A LEPR

2.54e-042139221300955
Pubmed

Sertoli Cell Wt1 Regulates Peritubular Myoid Cell and Fetal Leydig Cell Differentiation during Fetal Testis Development.

JAG1 LHX9

3.05e-042339228036337
Pubmed

OTUB1 modulates c-IAP1 stability to regulate signalling pathways.

BIRC3 RNF31

3.33e-042439223524849
Pubmed

Adamts18 modulates the development of the aortic arch and common carotid artery.

ADAMTS18 JAG1

3.91e-042639234189436
Pubmed

Characterization of a novel Lbx1 mouse loss of function strain.

FHL2 LHX9

3.91e-042639234906895
Pubmed

Functional proteomics mapping of a human signaling pathway.

PDCD6IP FHL2 ZNF107 ZZEF1 MYCBP2

4.98e-0459139515231748
Pubmed

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation.

BIRC3 RNF31

5.23e-043039230420664
Pubmed

ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.

ADAMTS18 HHIP

5.23e-043039232882513
Pubmed

Multiple genes encoding zinc finger domains are expressed in human T cells.

ZNF28 ZNF33B

5.58e-04313922288909
Pubmed

TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation.

BIRC3 RNF31

5.58e-043139225996949
Pubmed

ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling.

PDCD6IP JAG1

5.58e-043139237573008
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

SETD2 ZC3H7B RNF31 FHL2 PDLIM5

5.66e-0460839516713569
Pubmed

Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development.

HHIP JAG1

6.72e-043439223123965
Pubmed

MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons.

ADAMTS18 ISLR2

7.12e-043539222407321
Pubmed

Hepatitis C virus infection protein network.

SETD2 RNF31

1.03e-034239218985028
Pubmed

The protein interaction landscape of the human CMGC kinase group.

ZNF267 SETD2 CPSF4 PDCD6IP DSC1

1.03e-0369539523602568
InteractionTRIM28 interactions

ZNF823 ZNF267 BIRC3 ZNF799 ZNF28 ZNF33B ZC3H7B RNF31 FHL2 ZNF107 MYCBP2 ZNF738 ZNF257 PDLIM5 RBAK

1.72e-0814743715int:TRIM28
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF823 ZNF267 ZNF814 ZNF799 ZNF28 ZNF33B ZNF107 ZNF257 RBAK

2.15e-0671831928
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

SETD2 KMT2E

1.54e-0334312487
GeneFamilyLIM domain containing

FHL2 PDLIM5

4.58e-03593121218
CoexpressionGSE14308_TH2_VS_NATURAL_TREG_DN

GLIPR1L1 PAN3 RNF31 MYCBP2 PREX1 LEPR

4.70e-07199396M3369
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8|TCGA-Bladder / Sample_Type by Project: Shred V9

ZNF823 ZNF799 ZNF107 ZNF738

8.91e-061503941aa9320d97ff10994ea024751790524fe133aba9
ToppCellILEUM-inflamed-(1)_T_cell-(1)_Cytotoxic_CD8_Trm|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ZNF267 BIRC3 KMT2E CLEC2B

2.17e-05188394c80956649b10b7dd7540394a00fc2a0619b27e80
ToppCellILEUM-inflamed-(1)_T_cell-(1)_Th17_Trm|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ZNF267 BIRC3 KMT2E CLEC2B

2.35e-0519239412f7ea575da5d650c740e6060f5dab0478e563dd
ToppCellPCW_13-14-Endothelial-Endothelial_cycling|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ISLR2 PREX1 LEPR CLEC2B

2.65e-051983948fb624407abb9cb711d8d8a8665014cf6e39559a
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HHIP SRPX FHL2 CLEC2B

2.71e-0519939434199597371a20d9f1dea9ad59edfb615b14c4f6
ToppCellnormal_Lung-Endothelial_cells-Stalk-like_ECs|Endothelial_cells / Location, Cell class and cell subclass

SRPX MYCBP2 LEPR PDLIM5

2.76e-05200394413ac64bbe95b8c921c5396d8b5f298fec8c4f82
ToppCellTransplant_Alveoli_and_parenchyma-Endothelial-Endothelial|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X

BIRC3 SRPX LEPR PDLIM5

2.76e-052003942ae62c428728c1d9d4471d4be24bd6ab074fa22c
Drugdihydrotanshinone I

SETD2 JAG1

1.71e-054392CID005316743
DrugPiromidic acid [19562-30-2]; Up 200; 13.8uM; MCF7; HT_HG-U133A

ZC3H7B ZZEF1 LEPR PDLIM5 JAG1

1.99e-051953953335_UP
DrugCarbarsone [121-59-5]; Down 200; 15.4uM; MCF7; HT_HG-U133A

ZC3H7B RNF31 ZZEF1 PDLIM5 JAG1

2.09e-051973953250_DN
Diseaseleukemia

BIRC3 SETD2 KMT2E

4.19e-0555363C0023418
Diseaseasparaginase-induced acute pancreatitis

ADAMTS18 PDLIM5

5.18e-059362EFO_1001507
Diseasebirth weight, parental genotype effect measurement

HHIP GPRC6A PREX1 JAG1

8.70e-05192364EFO_0004344, EFO_0005939
Diseaseprimary dental caries

ADAMTS18 PDCD6IP

7.92e-0434362EFO_0600095
Diseaseneutrophil percentage of leukocytes

SETD2 CPSF4 ZC3H7B PREX1 LEPR

8.24e-04610365EFO_0007990
Diseasehuman immunodeficiency virus infectious disease (is_marker_for)

KMT2E LEPR

8.88e-0436362DOID:526 (is_marker_for)
Diseasecognitive function measurement, self reported educational attainment

ZNF799 ZC3H7B MYCBP2 PREX1

8.95e-04355364EFO_0004784, EFO_0008354
Diseaselymphocyte percentage of leukocytes

SETD2 CPSF4 ZC3H7B PREX1 LEPR

1.21e-03665365EFO_0007993
Diseasechronic obstructive pulmonary disease (is_implicated_in)

HHIP LEPR

2.70e-0363362DOID:3083 (is_implicated_in)
Diseaseaortic measurement

ADAMTS18 PREX1 PDLIM5

3.53e-03251363EFO_0020865
DiseaseMammary Neoplasms, Human

SETD2 FHL2 LEPR JAG1

3.72e-03525364C1257931
DiseaseMammary Carcinoma, Human

SETD2 FHL2 LEPR JAG1

3.72e-03525364C4704874
DiseaseMammary Neoplasms

SETD2 FHL2 LEPR JAG1

3.77e-03527364C1458155
DiseaseBreast Carcinoma

SETD2 FHL2 LEPR JAG1

4.06e-03538364C0678222
Diseasepreeclampsia

MYCBP2 PREX1

4.10e-0378362EFO_0000668
Diseasegranulocyte percentage of myeloid white cells

SETD2 PAN3 LEPR

4.24e-03268363EFO_0007997
Diseasedilated cardiomyopathy (implicated_via_orthology)

PDLIM5 JAG1

4.31e-0380362DOID:12930 (implicated_via_orthology)
Diseaselongitudinal BMI measurement

ZNF257 LEPR

4.52e-0382362EFO_0005937
Diseasemonocyte count

SETD2 ZNF799 PAN3 PREX1 LEPR JAG1

4.88e-031320366EFO_0005091
DiseaseFatty Liver

BIRC3 LEPR

5.19e-0388362C0015695
DiseaseSteatohepatitis

BIRC3 LEPR

5.19e-0388362C2711227
Diseasemyeloid white cell count

SETD2 KMT2E FHL2 PREX1 LEPR

5.32e-03937365EFO_0007988
DiseaseUterine leiomyoma

ZNF257 PDLIM5

5.54e-0391362HP_0000131
DiseaseNeurodevelopmental Disorders

SETD2 KMT2E

5.77e-0393362C1535926
Diseasetotal cortical area measurement

ADAMTS18 HHIP

5.90e-0394362EFO_0008381

Protein segments in the cluster

PeptideGeneStartEntry
CYFYSKFGDCSNKEC

CPSF4L

96

A6NMK7
FYYVGNSDDVKCFCC

BIRC3

281

Q13489
RCKLYCKAENFEFFF

ADAMTS18

681

Q8TE60
CVDKYAHQFADCAYK

ISLR2

26

Q6UXK2
ADYFGDAFKQCQYKD

PDCD6IP

221

Q8WUM4
CFAKDGSIYCKEDYY

LHX9

111

Q9NQ69
FDFDYGNCKYKVDCA

KMT2E

446

Q8IZD2
KDCYLQSDGFYECIF

LEPR

486

P48357
EKGALYCELCYEKFF

PDLIM5

461

Q96HC4
QYYLASCGDDCKVKF

EIPR1

241

Q53HC9
CFIFAFKGKYENYNE

GPRC6A

766

Q5T6X5
YYAKDKTCFYGEECQ

PAN3

51

Q58A45
FAYCLNCFCDLYAKK

FHL2

206

Q14192
KHCEDYVCSYNYEGK

DSC1

841

Q08554
DCLDKSYKCYAAFEY

GLIPR1L1

81

Q6UWM5
CYFYSKFGECSNKEC

CPSF4

96

O95639
TCDDYYYGFGCNKFC

JAG1

186

P78504
LKFKDKFCVYEEYCS

PREX1

136

Q8TCU6
DYVKDDKASFYGFKC

MYCBP2

2126

O75592
FKCVDGAYFNSRCEY

SRPX

131

P78539
EFCFYYARKDGGLCF

HHIP

166

Q96QV1
GFQNKCYYFSKEEGD

CLEC2B

41

Q92478
CLKEGYCNSLKYAFF

COA5

41

Q86WW8
QFCSGCYNAFYAKNK

RNF31

896

Q96EP0
YECKECGKAFSCFKY

ZNF823

471

P16415
YKCEECGKAFNQSYQ

ZNF107

496

Q9UII5
YKCEGCGKAFCQFSY

ZNF738

316

Q8NE65
YECHECGKIFYNKSY

ZNF33B

581

Q06732
ECYECGKFFSQKSYL

RBAK

596

Q9NYW8
NGCYDEKTFKYDQFD

ZNF267

126

Q14586
YECKECGKAFSCFQY

ZNF799

476

Q96GE5
YQFQRYGKEAQKCFC

SETD2

1666

Q9BYW2
CFKTYEDFKECFSAY

ZSWIM3

6

Q96MP5
DFDLCYGCYAAKKYS

ZZEF1

1851

O43149
YKCKVCDKAFAYNSY

ZNF28

411

P17035
YACEACQKFFRNKYQ

ZNF814

716

B7Z6K7
QFLEQKYGYYHCKDC

ZAR1

321

Q86SH2
KQDCKYGDNCTFAYH

ZC3H7B

491

Q9UGR2
REKAYKCDEYCKAFN

ZNF257

396

Q9Y2Q1