Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein-tyrosine sulfotransferase activity	TPST2 TPST1	1.51e-05	2	78	2	GO:0008476
GeneOntologyBiologicalProcess	peptidyl-tyrosine sulfation	TPST2 TPST1	1.45e-05	2	79	2	GO:0006478
Domain	TPST	TPST2 TPST1	1.72e-05	2	78	2	IPR026634
Domain	NSL3/Tex30	KANSL3 TEX30	1.72e-05	2	78	2	IPR026555
Domain	TM_Fragile-X-F-assoc	TMEM185B TMEM185A	1.03e-04	4	78	2	IPR019396
Domain	Tmemb_185A	TMEM185B TMEM185A	1.03e-04	4	78	2	PF10269
Domain	AA_TRANSFER_CLASS_2	SPTLC2 ALAS1	2.55e-04	6	78	2	PS00599
Domain	Aminotrans_II_pyridoxalP_BS	SPTLC2 ALAS1	2.55e-04	6	78	2	IPR001917
Domain	DOCK_C	DOCK1 DOCK7	9.24e-04	11	78	2	IPR010703
Domain	DHR-1_domain	DOCK1 DOCK7	9.24e-04	11	78	2	IPR027007
Domain	DHR_2	DOCK1 DOCK7	9.24e-04	11	78	2	PS51651
Domain	DHR_1	DOCK1 DOCK7	9.24e-04	11	78	2	PS51650
Domain	DOCK-C2	DOCK1 DOCK7	9.24e-04	11	78	2	PF14429
Domain	DHR-2	DOCK1 DOCK7	9.24e-04	11	78	2	IPR027357
Domain	DHR-2	DOCK1 DOCK7	9.24e-04	11	78	2	PF06920
Domain	DOCK	DOCK1 DOCK7	9.24e-04	11	78	2	IPR026791
Domain	Aminotransferase_I/II	SPTLC2 ALAS1	2.25e-03	17	78	2	IPR004839
Domain	Aminotran_1_2	SPTLC2 ALAS1	2.25e-03	17	78	2	PF00155
Domain	AAA+_ATPase	ABCA2 VWA8 PSMC5 CLPX	3.11e-03	144	78	4	IPR003593
Domain	AAA	ABCA2 VWA8 PSMC5 CLPX	3.11e-03	144	78	4	SM00382
Domain	-	MPP2 TPST2 TPST1 ABCA2 NPHP3 VWA8 PSMC5 CLPX CTPS1	3.83e-03	746	78	9	3.40.50.300
Domain	-	GALNT10 B4GALT7 ABO	4.73e-03	81	78	3	3.90.550.10
Pathway	REACTOME_GAMMA_CARBOXYLATION_HYPUSINYLATION_HYDROXYLATION_AND_ARYLSULFATASE_ACTIVATION	RIOX2 TPST2 TPST1 DOHH	6.53e-05	57	54	4	MM14634
Pathway	REACTOME_GAMMA_CARBOXYLATION_HYPUSINYLATION_HYDROXYLATION_AND_ARYLSULFATASE_ACTIVATION	RIOX2 TPST2 TPST1 DOHH	8.54e-05	61	54	4	M26993
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	CEP170 ABLIM1 ANK3 FBL AHNAK POLR2A DOCK7 TAB1 CTPS1	4.40e-06	549	79	9	38280479
Pubmed	Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.	CEP170 MPP2 ABLIM1 ANK3 HPRT1 AHNAK PANK4 PSMC5 ATP1A2	5.02e-06	558	79	9	35063084
Pubmed	Dynamic interactions between L-type voltage-sensitive calcium channel Cav1.2 subunits and ahnak in osteoblastic cells.	CACNA1C AHNAK	5.09e-06	2	79	2	19261907
Pubmed	Effects of CACNA1C and ANK3 on cognitive function in patients with bipolar disorder.	CACNA1C ANK3	5.09e-06	2	79	2	38657895
Pubmed	The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males.	CACNA1C ANK3	5.09e-06	2	79	2	21676128
Pubmed	Differential developmental deficits in retinal function in the absence of either protein tyrosine sulfotransferase-1 or -2.	TPST2 TPST1	5.09e-06	2	79	2	22745813
Pubmed	No association between bipolar disorder risk polymorphisms in ANK3 and CACNA1C and common migraine.	CACNA1C ANK3	5.09e-06	2	79	2	21395576
Pubmed	Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria.	ALAS1 CLPX	5.09e-06	2	79	2	28874591
Pubmed	ANK3 and CACNA1C--missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples.	CACNA1C ANK3	5.09e-06	2	79	2	22647524
Pubmed	A novel gene, FAM11A, associated with the FRAXF CpG island is transcriptionally silent in FRAXF full mutation.	TMEM185B TMEM185A	5.09e-06	2	79	2	12404111
Pubmed	Independent modulation of engagement and connectivity of the facial network during affect processing by CACNA1C and ANK3 risk genes for bipolar disorder.	CACNA1C ANK3	5.09e-06	2	79	2	24108394
Pubmed	Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment.	TPST2 TPST1	5.09e-06	2	79	2	16859706
Pubmed	Genetic analysis of SNPs in CACNA1C and ANK3 gene with schizophrenia: A comprehensive meta-analysis.	CACNA1C ANK3	5.09e-06	2	79	2	26227746
Pubmed	Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1.	TPST2 TPST1	5.09e-06	2	79	2	28821720
Pubmed	Detection and purification of tyrosine-sulfated proteins using a novel anti-sulfotyrosine monoclonal antibody.	TPST2 TPST1	5.09e-06	2	79	2	17046811
Pubmed	Salivary gland hypofunction in tyrosylprotein sulfotransferase-2 knockout mice is due to primary hypothyroidism.	TPST2 TPST1	5.09e-06	2	79	2	23951251
Pubmed	Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression.	CACNA1C ANK3	5.09e-06	2	79	2	20636642
Pubmed	Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans.	TPST2 TPST1	5.09e-06	2	79	2	9733778
Pubmed	Genetic polymorphism of antioxidant enzymes in eosinophilic and non-eosinophilic nasal polyposis.	CAT NOS2	5.09e-06	2	79	2	27515707
Pubmed	Shear stress mediates tyrosylprotein sulfotransferase isoform shift in human endothelial cells.	TPST2 TPST1	5.09e-06	2	79	2	12056800
Pubmed	Heme-dependent recognition of 5-aminolevulinate synthase by the human mitochondrial molecular chaperone ClpX.	ALAS1 CLPX	5.09e-06	2	79	2	34704252
Pubmed	Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation.	CACNA1C AHNAK	5.09e-06	2	79	2	16319140
Pubmed	Analysis of ANK3 and CACNA1C variants identified in bipolar disorder whole genome sequence data.	CACNA1C ANK3	5.09e-06	2	79	2	24716743
Pubmed	Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2.	TPST2 TPST1	5.09e-06	2	79	2	18672380
Pubmed	Early postnatal pulmonary failure and primary hypothyroidism in mice with combined TPST-1 and TPST-2 deficiency.	TPST2 TPST1	5.09e-06	2	79	2	18243191
Pubmed	Tyrosylprotein sulfotransferase-2 expression is required for sulfation of RNase 9 and Mfge8 in vivo.	TPST2 TPST1	5.09e-06	2	79	2	19047058
Pubmed	Tyrosine sulfation is a trans-Golgi-specific protein modification.	TPST2 TPST1	5.09e-06	2	79	2	3121635
Pubmed	Lack of protein-tyrosine sulfation disrupts photoreceptor outer segment morphogenesis, retinal function and retinal anatomy.	TPST2 TPST1	5.09e-06	2	79	2	21039965
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DOCK1 KANSL3 CEP170 CACNA1C CPAMD8 ABLIM1 GALNT10 ANK3 EEPD1 TTC12 PANK4 TSPYL2 CPT1A KLHL26	5.99e-06	1489	79	14	28611215
Pubmed	MicroRNA-30b-mediated regulation of catalase expression in human ARPE-19 cells.	HPRT1 CAT	1.53e-05	3	79	2	22880027
Pubmed	DsbA-L interacting with catalase in peroxisome improves tubular oxidative damage in diabetic nephropathy.	HPRT1 CAT	1.53e-05	3	79	2	37597421
Pubmed	[Quantifying gene expression in prostate carcinoma. Which endogenous reference genes are suitable?].	HPRT1 ALAS1	1.53e-05	3	79	2	17628775
Pubmed	Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients.	CAT NOS2	1.53e-05	3	79	2	27534583
Pubmed	Enhanced tyrosine sulfation is associated with chronic kidney disease-related atherosclerosis.	TPST2 TPST1	1.53e-05	3	79	2	37424015
Pubmed	Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence.	TPST2 TPST1	1.53e-05	3	79	2	12169668
Pubmed	Lack of tyrosylprotein sulfotransferase activity in hematopoietic cells drastically attenuates atherosclerosis in Ldlr-/- mice.	TPST2 TPST1	1.53e-05	3	79	2	19679829
Pubmed	Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor.	TPST2 TPST1	1.53e-05	3	79	2	10497246
Pubmed	ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.	CACNA1C ANK3	1.53e-05	3	79	2	21767209
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CEP170 ABLIM1 FBL HPRT1 AHNAK POLR2A DOCK7 PSMC5 CAT NUP188 HERC2	1.98e-05	1024	79	11	24711643
Pubmed	Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival.	PXDNL HPRT1 NOS2	2.21e-05	24	79	3	23728617
Pubmed	Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.	CEP170 FBL HPRT1 PSMC5 TAB1 HERC2 CTPS1	2.73e-05	383	79	7	29331416
Pubmed	Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways.	UBASH3B ZAP70	3.05e-05	4	79	2	21393235
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	DOCK1 CEP170 ABLIM1 ANK3 AHNAK DOCK7 PSMC5 CTPS1 EIF2AK3	3.30e-05	708	79	9	39231216
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	DOCK1 STARD13 KANSL3 CEP170 CPAMD8 TEX30 ANK3 AHNAK PSMC5 CYP7B1 EVPL LRRC36	3.40e-05	1293	79	12	15342556
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	DOCK1 STARD13 CEP170 ABLIM1 AHNAK DOCK7 CAT TAB1 CLPX SUFU	4.26e-05	916	79	10	32203420
Pubmed	Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.	CEP170 POLR2A HERC2	4.84e-05	31	79	3	22261722
Pubmed	Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2.	UBASH3B ZAP70	5.07e-05	5	79	2	14738763
Pubmed	Tyrosine sulfation of native mouse Psgl-1 is required for optimal leukocyte rolling on P-selectin in vivo.	TPST2 TPST1	5.07e-05	5	79	2	21633705
Pubmed	Imaging activity in neurons and glia with a Polr2a-based and cre-dependent GCaMP5G-IRES-tdTomato reporter mouse.	HPRT1 POLR2A	5.07e-05	5	79	2	25155958
Pubmed	Reference genes in the developing murine brain and in differentiating embryonic stem cells.	HPRT1 POLR2A	5.07e-05	5	79	2	22735032
Pubmed	Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor.	TMEM185B TMEM185A	5.07e-05	5	79	2	15525354
Pubmed	Genetic polymorphisms modifying oxidative stress are associated with disease activity in rheumatoid arthritis patients.	CAT NOS2	5.07e-05	5	79	2	19242068
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	KANSL3 FBL AHNAK POLR2A WDR76	5.36e-05	177	79	5	26206133
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	CEP170 FBL POLR2A TSPYL2 NUP188 HERC2 EIF2AK3	6.55e-05	440	79	7	34244565
Pubmed	α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.	ABLIM1 ANK3 CAT	7.01e-05	35	79	3	37381005
Pubmed	ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice.	CACNA1C EIF2AK3	7.60e-05	6	79	2	16352659
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	NPHP3 POLR2A DOCK7 PSMC5 HERC2 CLPX	8.11e-05	313	79	6	38270169
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	STARD13 ABCA2 LLGL2 ANK3 HPRT1 AHNAK POLR2A AP1M2 CPT1A	9.00e-05	807	79	9	30575818
Pubmed	A protein interaction landscape of breast cancer.	CEP170 ANK3 VWA8 SPTLC2 HPRT1 POLR2A NUP188 CLPX	9.76e-05	634	79	8	34591612
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	VWA8 POLR2A DOCK7 ATP1A2 CPT1A	1.00e-04	202	79	5	24639526
Pubmed	DDI2 protease controls embryonic development and inflammation via TCF11/NRF1.	PSMC5 NOS2 EIF2AK3	1.05e-04	40	79	3	39328932
Pubmed	SLC35B2 Acts in a Dual Role in the Host Sulfation Required for EV71 Infection.	TPST2 TPST1	1.06e-04	7	79	2	35420441
Pubmed	Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry.	TPST2 TPST1	1.06e-04	7	79	2	10089882
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	LLGL2 AHNAK PSMC5 TAB1 HERC2 UBASH3B CPT1A	1.14e-04	481	79	7	28190767
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CEP170 FBL AHNAK POLR2A DOCK7 PSMC5 NUP188 HERC2	1.20e-04	653	79	8	22586326
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CEP170 NPHP3 SPTLC2 EEPD1 DISP3 TXNDC16 PDZRN3	1.33e-04	493	79	7	15368895
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	NRDC FBL HPRT1 AP1M2 PSMC5 NUP188	1.36e-04	344	79	6	36282215
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	SPTBN5 VWA8 FBL PANK4 PSMC5 CAT ALAS1 TAB1 NUP188 HERC2 CLPX EIF2AK3	1.36e-04	1496	79	12	32877691
Pubmed	Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis.	HPRT1 POLR2A	1.41e-04	8	79	2	18331721
Pubmed	Determination of the sites of tyrosine O-sulfation in peptides and proteins.	TPST2 TPST1	1.41e-04	8	79	2	17558413
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KANSL3 TPST2 ABCA2 LLGL2 VWA8 AHNAK POLR2A NUP188 HERC2 SUFU	1.99e-04	1105	79	10	35748872
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	RIOX2 CEP170 POLR2A DOCK7 TAB1 NUP188 CTPS1	2.16e-04	534	79	7	35032548
Pubmed	RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain.	CEP170 HERC2	2.27e-04	10	79	2	29097665
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	AHNAK CAT TAB1 CLPX CTPS1	2.46e-04	245	79	5	35652658
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	CEP170 NRDC FBL HPRT1 DOCK7 PSMC5 EVPL CAT	2.60e-04	732	79	8	34732716
Pubmed	Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts.	TXNDC16 KLHL26	2.76e-04	11	79	2	22419666
Pubmed	PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.	HPRT1 DEF8	2.76e-04	11	79	2	27777970
Pubmed	Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.	CACNA1C ANK3	2.76e-04	11	79	2	20351715
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	CEP170 SPTLC2 HERC2 CPT1A	2.91e-04	139	79	4	25476789
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	CEP170 ABLIM1 DOCK7 TAB1 CTPS1	2.95e-04	255	79	5	15324660
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	RIOX2 KDM4D ABLIM1 LLGL2 FBL AHNAK DOCK7 CAT CTPS1	3.01e-04	949	79	9	36574265
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	ABLIM1 AHNAK DOCK7 PSMC5 CAT CTPS1	3.01e-04	399	79	6	37536630
Pubmed	Linkage mapping of murine homolog of the yeast SPT6 gene to MMU11B1.	POLR2A NOS2	3.31e-04	12	79	2	8662231
Pubmed	K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8(+) T cell activation.	UBASH3B ZAP70	3.31e-04	12	79	2	26390156
Pubmed	Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis.	HPRT1 GPANK1	3.31e-04	12	79	2	18835879
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	NRDC SPTLC2 TXNDC16 PSMC5 EVPL TAB1 NUP188 CPT1A SUFU	3.64e-04	974	79	9	28675297
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	TPST2 TPST1 GALNT10 ABCA2 B4GALT7 NETO2 SPTLC2 TXNDC16 CPT1A EIF2AK3	3.85e-04	1201	79	10	35696571
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CEP170 ABLIM1 VWA8 SPTLC2 AHNAK PANK4 DOCK7 PSMC5 NUP188 CLPX CTPS1	4.02e-04	1440	79	11	30833792
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	AHNAK TCIRG1 PSMC5 CLPX CPT1A MMP15	4.06e-04	422	79	6	27342126
Pubmed	Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity.	CPT1A NOS2	4.55e-04	14	79	2	27659424
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK1 DOCK7	4.55e-04	14	79	2	12432077
Pubmed	Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites.	ABLIM1 POLR2A	4.55e-04	14	79	2	15570572
Pubmed	Genomic analysis of mouse retinal development.	MPP2 DOHH ABCA2 B4GALT7 FBL POLR2A DEF8 UBASH3B CPT1A	4.60e-04	1006	79	9	15226823
Pubmed	Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.	SPTLC2 AP1M2 UBASH3B	5.08e-04	68	79	3	25754235
Pubmed	Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.	CAT NOS2	5.25e-04	15	79	2	19505917
Pubmed	Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy.	VWA8 FBL CAT TAB1 CTPS1	5.47e-04	292	79	5	35545034
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	FBL SPTLC2 HPRT1 POLR2A PANK4 PSMC5 NUP188 CLPX CPT1A CTPS1	5.50e-04	1257	79	10	37317656
Pubmed	DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis.	CEP170 ABLIM1 TEX30	5.53e-04	70	79	3	34255829
Pubmed	A novel PrP partner HS-1 associated protein X-1 (HAX-1) protected the cultured cells against the challenge of H₂O₂.	DOCK7 APLP1	5.99e-04	16	79	2	21301993
Pubmed	A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly.	STARD13 ANK3	5.99e-04	16	79	2	24535457
ToppCell	Hematolymphoid-Endothelial-NOSTRIN\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK1 CACNA1C ABLIM1 AHNAK CYP7B1 ATP1A2 PDZRN3	6.83e-08	200	79	7	032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCell	Hematolymphoid-Endothelial-NOSTRIN---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK1 CACNA1C ABLIM1 AHNAK CYP7B1 ATP1A2 PDZRN3	6.83e-08	200	79	7	68fce28690246895fd33354b30960ebcc31aa4cc
ToppCell	Hematolymphoid-Endothelial-NOSTRIN-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK1 CACNA1C ABLIM1 AHNAK CYP7B1 ATP1A2 PDZRN3	6.83e-08	200	79	7	376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCell	Hematolymphoid-Endothelial-NOSTRIN--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK1 CACNA1C ABLIM1 AHNAK CYP7B1 ATP1A2 PDZRN3	6.83e-08	200	79	7	7fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCell	Hematolymphoid-Endothelial-NOSTRIN----L2-6\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK1 CACNA1C ABLIM1 AHNAK CYP7B1 ATP1A2 PDZRN3	6.83e-08	200	79	7	878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCell	Hematolymphoid-Endothelial\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	DOCK1 CACNA1C ABLIM1 AHNAK CYP7B1 ATP1A2 PDZRN3	6.83e-08	200	79	7	7136936d05ab344a560cf159684c881063b5430d
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	CACNA1C ABLIM1 ANK3 PXDNL ATP1A2 PDZRN3	9.35e-07	184	79	6	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	CACNA1C ABLIM1 ANK3 VWA8 ATP1A2 PDZRN3	9.65e-07	185	79	6	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	CACNA1C ABLIM1 ANK3 VWA8 PXDNL PDZRN3	1.16e-06	191	79	6	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	ABLIM1 ANK3 AHNAK POLR2A TSPYL2 ZAP70	1.20e-06	192	79	6	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	droplet-Liver-Hepatocytes-24m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABLIM1 APLP1 RGS11 GPANK1 ZAP70	8.88e-06	157	79	5	cbb08d5c151f0622123276926a2a15bb7d271e90
ToppCell	droplet-Liver-Hepatocytes-24m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABLIM1 APLP1 RGS11 GPANK1 ZAP70	8.88e-06	157	79	5	16581e2399a211633f870dce326c75ff4b6a5fe6
ToppCell	T_cells-TFH-like_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	DOCK1 STARD13 NETO2 ETV6 CYP7B1	1.63e-05	178	79	5	e2ae43e5ec31de6197f2cbd6089f944adbf0a163
ToppCell	facs-Marrow-B-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD13 DISP3 APLP1 LRRN2 ATP1A2	1.72e-05	180	79	5	c54af6fb11484dacd3efa1f10a487376ff820a5e
ToppCell	facs-Marrow-B-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD13 DISP3 APLP1 LRRN2 ATP1A2	1.72e-05	180	79	5	07ac979b21be2425294d9818c48b5a1e6f014c19
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C ABLIM1 PXDNL ATP1A2 PDZRN3	1.96e-05	185	79	5	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LLGL2 NETO2 AP1M2 VWA2 LRRC36	2.17e-05	189	79	5	5d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	CACNA1C ABLIM1 ANK3 EIF2AK3 PDZRN3	2.17e-05	189	79	5	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	CACNA1C ABLIM1 VWA8 ATP1A2 PDZRN3	2.23e-05	190	79	5	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	CACNA1C ABLIM1 ANK3 VWA8 PDZRN3	2.23e-05	190	79	5	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	CACNA1C ABLIM1 ANK3 PXDNL PDZRN3	2.40e-05	193	79	5	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TPST2 ABLIM1 SPTLC2 LRRN2 VWA2	2.40e-05	193	79	5	7261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	LLGL2 NETO2 AP1M2 EVPL LRRC36	2.46e-05	194	79	5	c011cd59bb4ca4134331cba0f5d73bdbd7011d64
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	LLGL2 NETO2 AP1M2 EVPL LRRC36	2.46e-05	194	79	5	c47fc3f716ab091a39c20d7639ac783029589ee5
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	CACNA1C ABLIM1 ANK3 PXDNL PDZRN3	2.52e-05	195	79	5	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	ABCA2 LLGL2 AHNAK TSPYL2 ZAP70	2.65e-05	197	79	5	836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LLGL2 NETO2 AP1M2 EVPL LRRC36	2.65e-05	197	79	5	22b26bac3a99b20c73bfa6e6f81026d064eaa9e8
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ABCA2 LLGL2 ANK3 TSPYL2 ZAP70	2.65e-05	197	79	5	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / Treatment groups by lineage, cell group, cell type	ANK3 AP1M2 CAT ALAS1 MMP15	2.72e-05	198	79	5	d087e738d69ca9853553fde46d4e7a8906439d32
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GALNT10 ABCA2 LLGL2 AHNAK ZAP70	2.72e-05	198	79	5	a6b942fe850e287e1cb705684e29218072daf891
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 STARD13 ANK3 VWA8 ETV6	2.78e-05	199	79	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-DC3-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LLGL2 ETV6 CAT MMP15 SSUH2	2.78e-05	199	79	5	7271dbeca9aa838b88ad44d00059263a29c0316b
ToppCell	lymphoid-T_cell-CD8+_Naive_T_cell\|World / Lineage, cell class and subclass	TPST2 ABLIM1 FBL PSMC5 ZAP70	2.78e-05	199	79	5	4de81f29c4d79868fd6254ceb81b4ddad22ae7d0
ToppCell	Macroglial-Astrocytes-GFAP---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	ABLIM1 AHNAK DOCK7 ATP1A2 PDZRN3	2.85e-05	200	79	5	88d66550781a3c9102ff7455f5cff6fb072943cd
ToppCell	Macroglial-Astrocytes-GFAP-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	ABLIM1 AHNAK DOCK7 ATP1A2 PDZRN3	2.85e-05	200	79	5	d6a059b0ef763c281c60b1ac76da6079ea822f80
ToppCell	Macroglial-Astrocytes-GFAP--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	ABLIM1 AHNAK DOCK7 ATP1A2 PDZRN3	2.85e-05	200	79	5	16269fa4adb28fc6ed032bbdba8781237dd0d249
ToppCell	Macroglial-Astrocytes-GFAP----L1-2\|Macroglial / cells hierarchy compared to all cells using T-Statistic	ABLIM1 AHNAK DOCK7 ATP1A2 PDZRN3	2.85e-05	200	79	5	c6f43bbbd5df5f2c19ae385f1a6b6a330abede2f
ToppCell	Macroglial-Astrocytes-GFAP\|Macroglial / cells hierarchy compared to all cells using T-Statistic	ABLIM1 AHNAK DOCK7 ATP1A2 PDZRN3	2.85e-05	200	79	5	79634b1086934412ae92f259ab43554ce545008f
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Myh4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	STARD13 ABO NETO2 UBASH3B	8.20e-05	129	79	4	f83187c0bb06528127b8d2d56674ab1946846951
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D231\|Adult / Lineage, Cell type, age group and donor	LLGL2 DISP3 EVPL SSUH2	8.97e-05	132	79	4	8d30b71776f5f6da55dc78e0c5cb27be460004e3
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	NETO2 TAB1 NOS2 EIF2AK3	1.10e-04	139	79	4	2fdc8f36510aff24abbc79ef2a842db75a85f946
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	NETO2 TAB1 NOS2 EIF2AK3	1.10e-04	139	79	4	5970a654c64e3b54f9d18c102f5b125eec892fc5
ToppCell	PBMC-Mild-cDC_7\|Mild / Compartment, Disease Groups and Clusters	TPST1 DOHH ABO EVPL	1.19e-04	142	79	4	58f66f35646f281e64d634e6c26adbd1d4e6c830
ToppCell	facs-Marrow-KLS-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LLGL2 EEPD1 AP1M2 CYP7B1	1.75e-04	157	79	4	5d08ff0ba9d3df9cc30f13cab2d2b395ea6f3446
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	DOCK1 STARD13 TCIRG1 ATP1A2	1.75e-04	157	79	4	2c1219ee19a6246a3b9f5c2c1a37f26ea934a822
ToppCell	facs-Marrow-KLS-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LLGL2 EEPD1 AP1M2 CYP7B1	1.75e-04	157	79	4	ad9c9b7dfeee3ae46e7e593c51a0407df12195b4
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	MPP2 CACNA1C ATP1A2 PDZRN3	1.88e-04	160	79	4	fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCell	BL-critical-LOC-Epithelial-FOXN4+\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MPP2 DISP3 VWA2 NOS2	1.88e-04	160	79	4	3f737451d5713deed20061aa72a9ef77a9a2bc06
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	MPP2 CACNA1C ATP1A2 PDZRN3	1.93e-04	161	79	4	64891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCell	facs-Skin-Anagen-3m-Epithelial-inner_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DISP3 ADAMTS20 APLP1 ATP1A2	1.93e-04	161	79	4	8d2987271da52fd8353557ac6faa4f7a4be0ed2a
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C TSPYL2 ATP1A2 KLHL26	2.02e-04	163	79	4	8f24cef152f5965727bbeee116bd26c75cbba82a
ToppCell	droplet-Liver-Npc-21m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDM4D ABLIM1 LRRN2 ZAP70	2.02e-04	163	79	4	8569abb769543be55e066119c1dd1c505d5a177e
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C PXDNL ATP1A2 PDZRN3	2.07e-04	164	79	4	e3983f655cdba308fb192182829f17bef99ce0ba
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-Klrb1a/b/c(-)_NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIPK4 AHNAK APLP1 ZAP70	2.12e-04	165	79	4	eeb58d4db64ad37dc6b441eab22b05c24862e1a9
ToppCell	droplet-Liver-Npc-21m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDM4D ABLIM1 LRRN2 ZAP70	2.12e-04	165	79	4	6708beb0e8094f30cf5cd812e6a67a6db004a580
ToppCell	facs-Kidney-nan-3m-Lymphocytic\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDM4D ABLIM1 WDR76 ZAP70	2.12e-04	165	79	4	ba041deb0d9c187f251493ccd4794b5f09abd5aa
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KDM4D HPRT1 WDR76 ZAP70	2.12e-04	165	79	4	5f606959a060b1ae241217889560c6761ac73bbb
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TPST2 TEX30 TCIRG1 EIF2AK3	2.21e-04	167	79	4	0130743084dbcb20e10f96715d30961122150cbf
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TPST2 TEX30 TCIRG1 EIF2AK3	2.21e-04	167	79	4	7bcae3797d3a0811e7f39885afdfd29ec517f11b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TPST2 TEX30 TCIRG1 EIF2AK3	2.21e-04	167	79	4	c6f0209a1ad797631fdfa3efab6db6b1d3e8e315
ToppCell	368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	BNC1 ABO AP1M2 MMP15	2.27e-04	168	79	4	e870d2e69316406f45112ed0bf324b24f902a99e
ToppCell	droplet-Marrow-BM-1m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPP2 TPST1 AHNAK TTC12	2.27e-04	168	79	4	2e88d9cb7c80a4656fab290db8b45a5a0599d769
ToppCell	368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	BNC1 ABO AP1M2 MMP15	2.27e-04	168	79	4	403aba73a0f9ffb32252288d075fad8a588ca440
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C ATP1A2 UBASH3B PDZRN3	2.53e-04	173	79	4	1f16d47f5548e257e4b17f8070c5619780a9c5fd
ToppCell	367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	BNC1 ABO AP1M2 EVPL	2.53e-04	173	79	4	3d7c281a1a9f183a5a861d1a9c7b50d216535893
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1C PXDNL ATP1A2 PDZRN3	2.53e-04	173	79	4	cb6389536195443633adb06e5f1b7483530773d1
ToppCell	367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	BNC1 ABO AP1M2 EVPL	2.53e-04	173	79	4	3aa90578371039f81b7c6fa873ec70f8f2bc7dfa
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Lymphocytic-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK3 ADAMTS20 MMP15 ZAP70	2.59e-04	174	79	4	6987fe7959afce347282f632abc16d800ccab7c4
ToppCell	10x3'2.3-week_17-19-Neuro\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	STARD13 ANK3 ATP1A2 MMP15	2.65e-04	175	79	4	bbce8b1a160b414c0bf643c21c4e5e78fbccb7e1
ToppCell	10x3'2.3-week_17-19-Neuro-stroma-schwann_cells\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	STARD13 ANK3 ATP1A2 MMP15	2.65e-04	175	79	4	8b010220cdfb680ec839572f4933adfb85045ea6
ToppCell	10x3'2.3-week_17-19-Neuro-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	STARD13 ANK3 ATP1A2 MMP15	2.65e-04	175	79	4	0b579aeadcc06be83627391c0b01bd8605fdbdf3
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STARD13 ANK3 ADAMTS20 ATP1A2	2.76e-04	177	79	4	59cf56c385c324f0844f20003d2b5049a2791e45
ToppCell	Healthy/Control-pDC\|Healthy/Control / Disease group and Cell class	DOCK1 ATP1A2 MMP15 LRRC36	2.82e-04	178	79	4	072b346c6bbd63f00efaceda486400a669b3ec48
ToppCell	(06)_Krt4/13+\|World / shred by cell type and Timepoint	ABLIM1 AHNAK EVPL MMP15	2.82e-04	178	79	4	46efdf03aa1317bc600138e871509b995e773cce
ToppCell	Control-Fibroblasts-Airway_smooth_muscle\|Control / group, cell type (main and fine annotations)	CACNA1C PXDNL ATP1A2 PDZRN3	2.95e-04	180	79	4	d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C ATP1A2 UBASH3B PDZRN3	2.95e-04	180	79	4	01f2e5d96016823482f89ba503d007d4bd88eeac
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABLIM1 GALNT10 LLGL2 RGS11	3.01e-04	181	79	4	22363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABLIM1 HPRT1 AHNAK ALAS1	3.07e-04	182	79	4	ef65b095f4240d61cfd4a59aec19d72d324dba1d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABLIM1 HPRT1 AHNAK ALAS1	3.07e-04	182	79	4	97a805783a1f2b055c21307db250e3688674eff3
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C HPRT1 UBASH3B PDZRN3	3.07e-04	182	79	4	ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell	droplet-Heart-4Chambers-18m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LLGL2 AP1M2 EVPL RGS11	3.14e-04	183	79	4	2df1611c8acccb2a6f233d3d68bd9df2381a7278
ToppCell	mild_COVID-19-NK_CD56bright\|World / disease group, cell group and cell class (v2)	CACNA1C TPST2 ABLIM1 ZAP70	3.14e-04	183	79	4	9a4899afac0f91203209392c5f67b3d0aa356b86
ToppCell	Pericytes-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	CACNA1C RGS11 ATP1A2 PDZRN3	3.20e-04	184	79	4	cd10d351d91a81dd6dc806cb4e0c8d7861c98e0b
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MPP2 PXDNL RGS11 ATP1A2	3.20e-04	184	79	4	54e5b63f55b8d6eccad53d389ea9c78f991e1414
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MPP2 PXDNL RGS11 ATP1A2	3.20e-04	184	79	4	7b5678718719020b52e7c2a7bd9797987defd7ff
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	LLGL2 AP1M2 VWA2 LRRC36	3.20e-04	184	79	4	fa4915b0498f3069fd5ef497286445528f75187e
ToppCell	droplet-Limb_Muscle-nan-18m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK3 ADAMTS20 EVPL ATP1A2	3.20e-04	184	79	4	a7399a72f065d68800e3e0b2031d9894e0cc0ba4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 CPAMD8 ANK3 DOCK7	3.27e-04	185	79	4	d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C ANK3 ATP1A2 PDZRN3	3.34e-04	186	79	4	6add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LLGL2 AHNAK CPT1A ZAP70	3.34e-04	186	79	4	71e87c4c755ab607689cb050f5a363cb520a0f53
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK1 AHNAK ATP1A2 CPT1A	3.34e-04	186	79	4	73cf266aeecd3cc15e8cb6094588a393bca8fbe6
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CPAMD8 LLGL2 ABO ANK3	3.34e-04	186	79	4	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STARD13 APLP1 ATP1A2 MMP15	3.34e-04	186	79	4	6f88b68735d0f7c9904eb8413e6007910d556185
ToppCell	droplet-Tongue-nan-24m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK3 TTC12 EVPL PDZRN3	3.34e-04	186	79	4	18c06041c6c8a0ebac17b3c8aaebd67e652d315a
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LLGL2 EVPL VWA2 LRRC36	3.40e-04	187	79	4	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	CACNA1C CYP7B1 LRRN2 PDZRN3	3.40e-04	187	79	4	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 CPAMD8 ANK3 DOCK7	3.40e-04	187	79	4	2d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 CPAMD8 ANK3 DOCK7	3.40e-04	187	79	4	e3095455d2f255854f339f6b05fa87852af0700f
ToppCell	Control-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	NETO2 EEPD1 NOS2 PDZRN3	3.47e-04	188	79	4	88b3415e33db81726dd29c1f50c886e057af50a0
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	CACNA1C ETV6 CYP7B1 PDZRN3	3.47e-04	188	79	4	34e1b074a3995aa46ab194eb45115d76d1a5514d
Drug	Amiodarone	CACNA1C TPST1 ABCA2 NRDC HPRT1 AHNAK EEPD1 TSPYL2 TXNDC16 PSMC5 CYP7B1 CAT ALAS1 ATP1A2 CLPX CPT1A EIF2AK3 PDZRN3	1.75e-06	1469	78	18	ctd:D000638
Drug	Metolazone [17560-51-9]; Down 200; 11uM; MCF7; HT_HG-U133A	MPP2 ABCA2 APLP1 EVPL TAB1 WDR76 MMP15	5.30e-06	198	78	7	5392_DN
Drug	N-hydroxy-1-aminopyrene	HPRT1 CAT	1.16e-05	2	78	2	CID000114981
Drug	resokaempferol	APLP1 CAT	1.16e-05	2	78	2	CID005281611
Disease	Grand Mal Status Epilepticus	ANK3 CAT NOS2 EIF2AK3	3.21e-05	67	79	4	C0311335
Disease	Status Epilepticus, Subclinical	ANK3 CAT NOS2 EIF2AK3	3.21e-05	67	79	4	C0751522
Disease	Simple Partial Status Epilepticus	ANK3 CAT NOS2 EIF2AK3	3.21e-05	67	79	4	C0751524
Disease	Non-Convulsive Status Epilepticus	ANK3 CAT NOS2 EIF2AK3	3.21e-05	67	79	4	C0751523
Disease	Petit mal status	ANK3 CAT NOS2 EIF2AK3	3.21e-05	67	79	4	C0270823
Disease	Complex Partial Status Epilepticus	ANK3 CAT NOS2 EIF2AK3	3.21e-05	67	79	4	C0393734
Disease	Status Epilepticus	ANK3 CAT NOS2 EIF2AK3	3.40e-05	68	79	4	C0038220
Disease	Partial Fetal Alcohol Syndrome	ANK3 CAT	7.04e-05	5	79	2	C3661483
Disease	Bonnevie-Ullrich Syndrome	CAT NOS2	7.04e-05	5	79	2	C1527168
Disease	Alcohol Related Neurodevelopmental Disorder	ANK3 CAT	7.04e-05	5	79	2	C0814154
Disease	Turner Syndrome	CAT NOS2	7.04e-05	5	79	2	C0041408
Disease	Gonadal Dysgenesis, 45,X	CAT NOS2	7.04e-05	5	79	2	C0242526
Disease	Curling Ulcer	ABO NOS2	1.05e-04	6	79	2	C0010474
Disease	Alcohol Related Birth Defect	ANK3 CAT	1.05e-04	6	79	2	C3146244
Disease	Duodenal Ulcer	ABO NOS2	1.05e-04	6	79	2	C0013295
Disease	protein-tyrosine sulfotransferase 2 measurement	TPST2 ABO	1.96e-04	8	79	2	EFO_0801971
Disease	protein FAM177A1 measurement	ABO AP1M2	1.96e-04	8	79	2	EFO_0801948
Disease	semaphorin-3G measurement	ABO TAB1	1.96e-04	8	79	2	EFO_0802049
Disease	Marfan Syndrome, Type I	CAT NOS2	2.52e-04	9	79	2	C4721845
Disease	hypertension (is_implicated_in)	NPHP3 ABO ATP1A2 NOS2	3.19e-04	121	79	4	DOID:10763 (is_implicated_in)
Disease	Marfan Syndrome	CAT NOS2	3.83e-04	11	79	2	C0024796
Disease	cholesteryl esters to total lipids in very large VLDL percentage	ABO DOCK7 CPT1A	3.93e-04	53	79	3	EFO_0022258
Disease	cholesterol to total lipids in very large VLDL percentage	ABO DOCK7 CPT1A	4.15e-04	54	79	3	EFO_0022244
Disease	Alzheimer's disease (implicated_via_orthology)	PSMC5 APLP1 NOS2	4.87e-04	57	79	3	DOID:10652 (implicated_via_orthology)
Disease	Reactive Hyperemia	CAT NOS2	5.42e-04	13	79	2	C0178824
Disease	lung disease (implicated_via_orthology)	CAT NOS2	5.42e-04	13	79	2	DOID:850 (implicated_via_orthology)
Disease	Venous Engorgement	CAT NOS2	5.42e-04	13	79	2	C0042484
Disease	Fetal Alcohol Spectrum Disorders	ANK3 CAT	5.42e-04	13	79	2	C2985290
Disease	leukemia (is_implicated_in)	ABO ETV6	5.42e-04	13	79	2	DOID:1240 (is_implicated_in)
Disease	Active Hyperemia	CAT NOS2	5.42e-04	13	79	2	C0333233
Disease	Hyperemia	CAT NOS2	5.42e-04	13	79	2	C0020452
Disease	cutaneous melanoma, hair color	AHNAK LRRN2 HERC2	6.23e-04	62	79	3	EFO_0000389, EFO_0003924
Disease	actinic keratosis	DEF8 HERC2	6.31e-04	14	79	2	EFO_0002496
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	MPP2 ABO EEPD1 DOCK7 CPT1A	7.25e-04	264	79	5	EFO_0008317, EFO_0020944
Disease	response to olanzapine	CACNA1C ATP1A2	7.27e-04	15	79	2	GO_0097333
Disease	Antibody Deficiency Syndrome	CACNA1C ZAP70	9.38e-04	17	79	2	C0003257
Disease	otitis media (biomarker_via_orthology)	CAT NOS2	9.38e-04	17	79	2	DOID:10754 (biomarker_via_orthology)
Disease	Fetal Alcohol Syndrome	ANK3 CAT	9.38e-04	17	79	2	C0015923
Disease	Gastric ulcer	CAT NOS2	1.05e-03	18	79	2	C0038358
Disease	neck circumference	ADAMTS20 PDZRN3	1.18e-03	19	79	2	EFO_0011043
Disease	acetone measurement	VWA8 SCART1	1.18e-03	19	79	2	EFO_0010989
Disease	FEV/FEC ratio	STARD13 SPTBN5 LLGL2 PANK4 ETV6 LRRN2 UBASH3B SUFU MMP15 PDZRN3	1.60e-03	1228	79	10	EFO_0004713
Disease	free cholesterol:total lipids ratio, intermediate density lipoprotein measurement	ABO DOCK7 CPT1A	1.61e-03	86	79	3	EFO_0008595, EFO_0020945
Disease	influenza A (H1N1)	MPP2 PXDNL APLP1	1.67e-03	87	79	3	EFO_1001488
Disease	Hypertensive disease	CACNA1C CAT ATP1A2 NOS2	1.72e-03	190	79	4	C0020538
Disease	obsolete Mendelian syndromes with cleft lip/palate	TXNDC16 KLHL26	1.73e-03	23	79	2	MONDO_0015335
Disease	Immunologic Deficiency Syndromes	CACNA1C ZAP70	1.73e-03	23	79	2	C0021051
Disease	Anhedonia	CACNA1C ANK3	1.88e-03	24	79	2	C0178417
Disease	sleep duration, low density lipoprotein cholesterol measurement	ABO DOCK7 AP1M2	1.89e-03	91	79	3	EFO_0004611, EFO_0005271
Disease	response to gemcitabine	DOCK1 CACNA1C	2.04e-03	25	79	2	GO_0036272
Disease	Involutional paraphrenia	CACNA1C CAT	2.04e-03	25	79	2	C1571983
Disease	Psychosis, Involutional	CACNA1C CAT	2.04e-03	25	79	2	C1571984
Disease	Involutional Depression	CACNA1C CAT	2.04e-03	25	79	2	C0011574
Disease	response to TNF antagonist, joint damage measurement	DOCK1 MPP2	2.04e-03	25	79	2	EFO_0004653, EFO_0005413
Disease	colorectal health	DOCK1 MPP2 VWA8 HERC2	2.11e-03	201	79	4	EFO_0008460
Disease	factor VIII measurement, von Willebrand factor measurement	ABO TAB1	2.38e-03	27	79	2	EFO_0004629, EFO_0004630

Protein segments in the cluster

Peptide	Gene	Start	Entry
VRELFVMAREHAPSI	PSMC5	231	P62195
RAMLDAHPDIRCGEE	TPST1	86	O60507
HRLPREMIFVGRDDC	CEP170	16	Q5SW79
IERKIMDHPGFREFC	DISP3	301	Q9P2K9
EHFMPLLVQREEEGA	AP1M2	31	Q9Y6Q5
SLERGFCMAVREPDH	ABO	46	P16442
VFTDEMAHFDRERIP	CAT	56	P04040
HVEARDLIEFGMIPE	CLPX	481	O76031
VGHFELRYIPDMETR	EIF2AK3	261	Q9NZJ5
ERHLAPEVFREIFGM	ABLIM1	741	O14639
ALIMVPREVEDGGHE	BNC1	641	Q01954
LVPEGCRFLHQERMD	APLP1	151	P51693
RIPGEETDTIQHMRD	CPT1A	316	P50416
RELVGREMGVDVHFP	AHNAK	5671	Q09666
CHTVMVRESPRERPD	ATP8B3	571	O60423
TRQEPMVRHEAGEAL	DOHH	81	Q9BU89
REHGPFRSVEDLVRM	EEPD1	166	Q7L9B9
VMIHREEEGPVINFD	ADAMTS20	311	P59510
VEAHMRDACDARPVG	PDZRN3	126	Q9UPQ7
ELLEDPVGRAHFMDF	RGS11	306	O94810
CRRPDEDHIYQEEML	NOS2	1016	P35228
EEHAMPIGRIADCRL	ETV6	326	P41212
RVFEMVEALQEHPRD	LLGL2	186	Q6P1M3
EAGFPEVARMVRESH	GPANK1	186	O95872
CMRGLDPEEAHVIRF	HIPK4	61	Q8NE63
FCRRPLHFEVMSERE	ALAS1	611	P13196
RHDPLTVMDGVNRIV	HERC2	3651	O95714
ATMVRDRQHGPVVEL	HERC2	4406	O95714
IVCPMIDVIDHDDFR	GALNT10	261	Q86SR1
LPVREVPFREMTDHC	LRRN2	406	O75325
SILRDFMGCQEHVEP	MMP15	551	P51511
FRERFEELLVFVPHM	B4GALT7	101	Q9UBV7
HPEDTMKAFCRRELE	LRRC36	576	Q1X8D7
LEDDGERMVELRHPA	EVPL	286	Q92817
VMVEPHRHEGVFICR	FBL	86	P22087
DRAVVDHMEPRVPAS	KDM4D	341	Q6B0I6
DRHELLIYEEVARMP	MPP2	356	Q14168
HRRVEGFLCEVPAMI	OR2C1	171	O95371
DLERVFIPHGLIMDR	HPRT1	31	P00492
LIVAERIAGMDPVVH	PANK4	666	Q9NVE7
RDPLIVEMARAGEIF	PXDNL	651	A1KZ92
EVGRTPIAMEIEHFI	ATP1A2	276	P50993
PGARHFRELTEMEVG	KLHL26	336	Q53HC5
HVPMCEDLELRRDSG	CACNA1C	1866	Q13936
VTEALRPFHERMEAC	DOCK1	1586	Q14185
ALDEHLFPVRIGDMR	DOCK7	746	Q96N67
RDMIPADVPEHFRGR	CPAMD8	301	Q8IZJ3
RRFEETRGMEEEPTH	ABCA2	971	Q9BZC7
PCERTDIRMAIVADH	ANK3	4086	Q12955
RCPERVMDLGLSEDH	DEF8	116	Q6ZN54
CHPEAMEDFREKIRA	KANSL3	411	Q9P2N6
HPEAMAAVRDEIDRL	CYP7B1	311	O75881
IMECDRLFEVPHELV	STARD13	861	Q9Y3M8
GERARFCPRHEDMTL	TAB1	346	Q15750
MFEVLVCDRIERGSH	TMEM185A	96	Q8NFB2
MFEVLVCDRVERGTH	TMEM185B	96	Q9H7F4
EMRERVLGPDHPDCA	NPHP3	1121	Q7Z494
LEDGEDVRRLPCMHL	RNF165	301	Q6ZSG1
GERMEIVELEDHPFF	CTPS1	506	P17812
MEEIPCEIYVRGRED	NETO2	501	Q8NC67
SPVEARRMLEEHQEC	SPTBN5	2501	Q9NRC6
FLEHRVPAMTEEVAR	SSUH2	66	Q9Y2M2
AMLDAHPEVRCGEET	TPST2	86	O60704
RKHDDDRRFMCPVEG	ZXDB	476	P98169
QPGVFDCLRDAMVRD	ZAP70	111	P43403
RAIGIPEHRAVMEAA	TXNDC16	166	Q9P2K2
RGRCEVVIMEDAPDY	TSPYL2	416	Q9H2G4
VPGARVDIMERQSHD	SPTLC2	141	O15270
VERHMCDGDIVIFNR	POLR2A	446	P24928
TDMRRGETIFEIDPH	SUFU	236	Q9UMX1
PCEHRTLEMVREFAG	VWA2	241	Q5GFL6
HPLMIRDAIDREVEA	NRDC	296	O43847
RHLVDETMDPFVDRI	NUP188	251	Q5SRE5
VLHVEEAMVFCRELG	SCART1	161	Q4G0T1
VMCHIEPDDGDDFVR	TEX30	111	Q5JUR7
VEAEERIGRPVHEFM	RIOX2	211	Q8IUF8
DCVIVGSMAHPRRVE	WDR76	561	Q9H967
EPTTRRHMAACEEFG	TTC12	461	Q9H892
LFVCRHGERMDVVFG	UBASH3B	386	Q8TF42
GRENVVVIHPDFRMI	VWA8	886	A3KMH1
MEEGVSAVAHRIPCR	TCIRG1	341	Q13488