Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmicrotubule binding

SYBU MAP4K4

2.30e-0330852GO:0008017
GeneOntologyMolecularFunctiontubulin binding

SYBU MAP4K4

4.39e-0342852GO:0015631
GeneOntologyBiologicalProcessregulation of insulin secretion involved in cellular response to glucose stimulus

SYBU MAP4K4 CACNA1E

8.53e-079253GO:0061178
GeneOntologyBiologicalProcessinsulin secretion involved in cellular response to glucose stimulus

SYBU MAP4K4 CACNA1E

1.17e-0610253GO:0035773
GeneOntologyBiologicalProcessregulation of protein transport

PCM1 SYBU MAP4K4 CACNA1E

2.63e-0656054GO:0051223
GeneOntologyBiologicalProcessregulation of establishment of protein localization

PCM1 SYBU MAP4K4 CACNA1E

5.51e-0667454GO:0070201
GeneOntologyBiologicalProcessregulation of secretion by cell

RIC1 SYBU MAP4K4 CACNA1E

7.98e-0674054GO:1903530
GeneOntologyBiologicalProcesscellular response to glucose stimulus

SYBU MAP4K4 CACNA1E

8.33e-0619653GO:0071333
GeneOntologyBiologicalProcesscellular response to hexose stimulus

SYBU MAP4K4 CACNA1E

8.72e-0619953GO:0071331
GeneOntologyBiologicalProcesscellular response to monosaccharide stimulus

SYBU MAP4K4 CACNA1E

8.99e-0620153GO:0071326
GeneOntologyBiologicalProcessregulation of secretion

RIC1 SYBU MAP4K4 CACNA1E

1.09e-0580154GO:0051046
GeneOntologyBiologicalProcesscellular response to carbohydrate stimulus

SYBU MAP4K4 CACNA1E

1.10e-0521553GO:0071322
GeneOntologyBiologicalProcessintracellular glucose homeostasis

SYBU MAP4K4 CACNA1E

1.15e-0521853GO:0001678
GeneOntologyBiologicalProcessregulation of insulin secretion

SYBU MAP4K4 CACNA1E

1.36e-0523153GO:0050796
GeneOntologyBiologicalProcessresponse to glucose

SYBU MAP4K4 CACNA1E

1.94e-0526053GO:0009749
GeneOntologyBiologicalProcessresponse to hexose

SYBU MAP4K4 CACNA1E

2.06e-0526553GO:0009746
GeneOntologyBiologicalProcessresponse to monosaccharide

SYBU MAP4K4 CACNA1E

2.22e-0527253GO:0034284
GeneOntologyBiologicalProcessinsulin secretion

SYBU MAP4K4 CACNA1E

2.27e-0527453GO:0030073
GeneOntologyBiologicalProcessregulation of peptide hormone secretion

SYBU MAP4K4 CACNA1E

2.35e-0527753GO:0090276
GeneOntologyBiologicalProcessregulation of peptide transport

SYBU MAP4K4 CACNA1E

2.48e-0528253GO:0090087
GeneOntologyBiologicalProcessregulation of peptide secretion

SYBU MAP4K4 CACNA1E

2.48e-0528253GO:0002791
GeneOntologyBiologicalProcessresponse to carbohydrate

SYBU MAP4K4 CACNA1E

3.01e-0530153GO:0009743
GeneOntologyBiologicalProcesssecretion by cell

RIC1 SYBU MAP4K4 CACNA1E

3.38e-05106454GO:0032940
GeneOntologyBiologicalProcessregulation of protein localization

PCM1 SYBU MAP4K4 CACNA1E

3.68e-05108754GO:0032880
GeneOntologyBiologicalProcesspeptide hormone secretion

SYBU MAP4K4 CACNA1E

4.11e-0533453GO:0030072
GeneOntologyBiologicalProcessglucose homeostasis

SYBU MAP4K4 CACNA1E

4.26e-0533853GO:0042593
GeneOntologyBiologicalProcesscarbohydrate homeostasis

SYBU MAP4K4 CACNA1E

4.29e-0533953GO:0033500
GeneOntologyBiologicalProcesspeptide secretion

SYBU MAP4K4 CACNA1E

4.45e-0534353GO:0002790
GeneOntologyBiologicalProcessexport from cell

RIC1 SYBU MAP4K4 CACNA1E

4.64e-05115354GO:0140352
GeneOntologyBiologicalProcessregulation of protein secretion

SYBU MAP4K4 CACNA1E

4.72e-0535053GO:0050708
GeneOntologyBiologicalProcessregulation of hormone secretion

SYBU MAP4K4 CACNA1E

4.93e-0535553GO:0046883
GeneOntologyBiologicalProcesspeptide transport

SYBU MAP4K4 CACNA1E

4.93e-0535553GO:0015833
GeneOntologyBiologicalProcessregulation of cellular localization

PCM1 SYBU MAP4K4 CACNA1E

5.66e-05121254GO:0060341
GeneOntologyBiologicalProcesssecretion

RIC1 SYBU MAP4K4 CACNA1E

5.82e-05122154GO:0046903
GeneOntologyBiologicalProcesshormone secretion

SYBU MAP4K4 CACNA1E

8.13e-0542053GO:0046879
GeneOntologyBiologicalProcessamide transport

SYBU MAP4K4 CACNA1E

8.13e-0542053GO:0042886
GeneOntologyBiologicalProcesshormone transport

SYBU MAP4K4 CACNA1E

8.84e-0543253GO:0009914
GeneOntologyBiologicalProcessprotein secretion

SYBU MAP4K4 CACNA1E

1.21e-0448053GO:0009306
GeneOntologyBiologicalProcessestablishment of protein localization to extracellular region

SYBU MAP4K4 CACNA1E

1.23e-0448353GO:0035592
GeneOntologyBiologicalProcessprotein localization to extracellular region

SYBU MAP4K4 CACNA1E

1.29e-0449053GO:0071692
GeneOntologyBiologicalProcessmicrotubule-based movement

PCM1 SYBU CACNA1E

1.31e-0449353GO:0007018
GeneOntologyBiologicalProcesssignal release

SYBU MAP4K4 CACNA1E

3.01e-0465353GO:0023061
GeneOntologyBiologicalProcessregulation of hormone levels

SYBU MAP4K4 CACNA1E

3.45e-0468453GO:0010817
GeneOntologyBiologicalProcesscytosolic transport

RIC1 SYBU

5.18e-0415052GO:0016482
GeneOntologyBiologicalProcessintracellular chemical homeostasis

SYBU MAP4K4 CACNA1E

6.92e-0486653GO:0055082
GeneOntologyBiologicalProcesstransport along microtubule

PCM1 SYBU

8.91e-0419752GO:0010970
GeneOntologyBiologicalProcesscellular homeostasis

SYBU MAP4K4 CACNA1E

9.98e-0498153GO:0019725
GeneOntologyBiologicalProcesscytoskeleton-dependent intracellular transport

PCM1 SYBU

1.16e-0322552GO:0030705
GeneOntologyBiologicalProcessmicrotubule-based process

PCM1 SYBU CACNA1E

1.24e-03105853GO:0007017
GeneOntologyBiologicalProcesspositive regulation of GTPase activity

RIC1 MAP4K4

1.36e-0324452GO:0043547
GeneOntologyBiologicalProcessmicrotubule-based transport

PCM1 SYBU

1.46e-0325352GO:0099111
GeneOntologyBiologicalProcesschemical homeostasis

SYBU MAP4K4 CACNA1E

2.02e-03124953GO:0048878
GeneOntologyBiologicalProcesspositive regulation of protein transport

PCM1 SYBU

2.31e-0331952GO:0051222
GeneOntologyBiologicalProcessregulation of GTPase activity

RIC1 MAP4K4

2.55e-0333552GO:0043087
GeneOntologyBiologicalProcesscellular response to oxygen-containing compound

SYBU MAP4K4 CACNA1E

3.11e-03145053GO:1901701
GeneOntologyBiologicalProcessintracellular transport

PCM1 RIC1 SYBU

3.41e-03149653GO:0046907
GeneOntologyBiologicalProcesspositive regulation of establishment of protein localization

PCM1 SYBU

3.66e-0340352GO:1904951
GeneOntologyBiologicalProcesspositive regulation of hydrolase activity

RIC1 MAP4K4

5.56e-0349952GO:0051345
GeneOntologyBiologicalProcessestablishment of organelle localization

PCM1 SYBU

6.63e-0354652GO:0051656
GeneOntologyBiologicalProcesspositive regulation of protein localization

PCM1 SYBU

7.74e-0359152GO:1903829
PathwayWP_MAPK_SIGNALING

MAP4K4 CACNA1E

1.78e-0324642M39597
PathwayKEGG_MAPK_SIGNALING_PATHWAY

MAP4K4 CACNA1E

2.09e-0326742M10792
Pubmed

Phosphoproteomic analysis of the developing mouse brain.

PCM1 SYBU MAP4K4

3.46e-062465315345747
InteractionTNIK interactions

PCM1 MAP4K4 CACNA1E

6.52e-0538153int:TNIK
InteractionDISC1 interactions

PCM1 SYBU MAP4K4

9.28e-0542953int:DISC1
InteractionATG14 interactions

PCM1 MAP4K4

1.15e-046952int:ATG14
InteractionSLC25A41 interactions

PCM1 MAP4K4

1.96e-049052int:SLC25A41
InteractionMIS18A interactions

PCM1 SYBU

2.22e-049652int:MIS18A
InteractionMOB4 interactions

PCM1 MAP4K4

5.42e-0415052int:MOB4
InteractionSTRN interactions

PCM1 MAP4K4

5.71e-0415452int:STRN
InteractionNME7 interactions

PCM1 MAP4K4

6.17e-0416052int:NME7
InteractionSTRN4 interactions

PCM1 MAP4K4

6.32e-0416252int:STRN4
InteractionCEP162 interactions

PCM1 SYBU

6.80e-0416852int:CEP162
InteractionCEP290 interactions

PCM1 MAP4K4

7.71e-0417952int:CEP290
InteractionCEP152 interactions

PCM1 MAP4K4

7.71e-0417952int:CEP152
InteractionCNTRL interactions

PCM1 MAP4K4

8.95e-0419352int:CNTRL
InteractionVPS33B interactions

PCM1 MAP4K4

9.51e-0419952int:VPS33B
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

PCM1 RIC1 MAP4K4

3.15e-0618053M8239
CoexpressionFAN_EMBRYONIC_CTX_EX_4_EXCITATORY_NEURON

SYBU CACNA1E

3.94e-0416652M39026
CoexpressionGSE41867_DAY15_EFFECTOR_VS_DAY30_MEMORY_CD8_TCELL_LCMV_ARMSTRONG_DN

PCM1 CACNA1E

5.15e-0419052M9521
CoexpressionGSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_DN

PCM1 SYBU

5.43e-0419552M10022
CoexpressionGSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_DN

PCM1 SYBU

5.48e-0419652M10002
CoexpressionGSE12366_GC_VS_MEMORY_BCELL_UP

SYBU MAP4K4

5.59e-0419852M3171
CoexpressionGSE11924_TH1_VS_TH17_CD4_TCELL_DN

PCM1 MAP4K4

5.65e-0419952M3163
CoexpressionGSE20366_TREG_VS_NAIVE_CD4_TCELL_HOMEOSTATIC_CONVERSION_DN

RIC1 MAP4K4

5.65e-0419952M4331
CoexpressionHOLLMANN_APOPTOSIS_VIA_CD40_UP

PCM1 MAP4K4

5.88e-0420352M9695
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MAP4K4 CACNA1E

1.44e-0417252965a9f62b73a7e3531c343121a7c507b7e1bfe05
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil-Neu_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MAP4K4 CACNA1E

1.46e-0417352bf685025961e79b379f2c35464b6c8ce3e31ace0
ToppCellBAL-Severe-Myeloid-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MAP4K4 CACNA1E

1.46e-04173525b76d9cc56bbb29017e64a2d0a3c76c0be003d96
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MAP4K4 CACNA1E

1.46e-0417352c37dba3804df7c3151e18e6ae4e0b6e7a92bae97
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil-Neu_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MAP4K4 CACNA1E

1.46e-04173521edef5aeab626cbf2c09468e77b02cfa2d21ba03
ToppCellBAL-Severe-Myeloid-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MAP4K4 CACNA1E

1.46e-0417352a6e73a40b0d5356564a594053e772f9d061a5919
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MAP4K4 CACNA1E

1.46e-0417352a8b5370f4c893a20c58e97659f3ac168699693f8
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYBU CACNA1E

1.49e-04175528362a46f5804333baa84cd56d450bc147f372a7e
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYBU CACNA1E

1.49e-04175528b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCellSevere-Myeloid-Neutrophil|Severe / Condition, Lineage, Cell class and cell subclass

MAP4K4 CACNA1E

1.54e-0417852454313efe59d71e7327b9758efabf2d893e4a8fd
ToppCellSevere-Myeloid-Neutrophil-|Severe / Condition, Lineage, Cell class and cell subclass

MAP4K4 CACNA1E

1.54e-04178528618ae891d62bf70fe860ff7bb2d31868961aa13
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCM1 CACNA1E

1.56e-0417952d15182c668d7c37be8214cad9f1fe35d1409c9a1
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MAP4K4 CACNA1E

1.56e-04179526624a2e731ab2d6c2eec19445e3dc509f581a8a9
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCM1 CACNA1E

1.56e-0417952e22a275a7c0ed19113c833a75d6c49fcc19aa13a
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

PCM1 MAP4K4

1.82e-0419352e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-41|World / Primary Cells by Cluster

MAP4K4 CACNA1E

1.87e-0419652dee0984cd63a1a2fdebb4421af48ab566a5b684e
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-cortical_neurons_2|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

SYBU CACNA1E

1.95e-04200520cb0755a101ec655359d051d6a8807408d727c55
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer|World / Primary Cells by Cluster

SYBU CACNA1E

1.95e-0420052db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21|World / Primary Cells by Cluster

SYBU CACNA1E

1.95e-042005230a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
DrugIsotretinoin [4759-48-2]; Up 200; 13.4uM; MCF7; HT_HG-U133A

PCM1 SYBU

6.74e-04189527438_UP
DrugSyrosingopine [84-36-6]; Up 200; 6uM; MCF7; HT_HG-U133A

PCM1 SYBU

6.96e-04192526213_UP
DrugBetahistine mesylate [54856-23-4]; Down 200; 17.2uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.03e-04193522833_DN
DrugMethapyrilene hydrochloride [135-23-9]; Down 200; 13.4uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.10e-04194524990_DN
Drugradicicol, diheterospora chlamydosporia; Down 200; 0.1uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.10e-04194525216_DN
DrugGlafenine hydrochloride [65513-72-6]; Down 200; 9.8uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.18e-04195527018_DN
DrugProcyclidine hydrochloride [1508-76-5]; Down 200; 12.4uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.18e-04195523330_DN
DrugAmodiaquin dihydrochloride dihydrate [6398-98-7]; Up 200; 8.6uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.18e-04195526224_UP
DrugFlucloxacillin sodium [1847-24-1]; Up 200; 8.4uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.25e-04196525527_UP
DrugPHA-00851261E [724719-49-7]; Down 200; 10uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.25e-04196523965_DN
DrugEstradiol-17 beta [50-28-2]; Up 200; 14.6uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.25e-04196525318_UP
DrugLiothyronine [6893-02-3]; Down 200; 6.2uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.25e-04196523324_DN
DrugBenserazide hydrochloride [14919-77-8]; Up 200; 13.6uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.25e-04196525322_UP
DrugMethylhydantoin-5-(D) [55147-68-7]; Down 200; 35uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.25e-04196523333_DN
DrugSR-95639A [115767-94-7]; Down 200; 10uM; MCF7; HT_HG-U133A

PCM1 MAP4K4

7.25e-04196523272_DN
DrugAceclofenac [89796-99-6]; Down 200; 11.2uM; MCF7; HT_HG-U133A

PCM1 MAP4K4

7.25e-04196527029_DN
Drug9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.32e-04197527500_UP
DrugBambuterol hydrochloride [81732-46-9]; Up 200; 10uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.32e-04197527239_UP
DrugBumetanide [28395-03-1]; Up 200; 11uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.32e-04197527440_UP
DrugAcenocoumarol [152-72-7]; Up 200; 11.4uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.40e-04198527232_UP
DrugEstriol [50-27-1]; Up 200; 13.8uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.40e-04198527220_UP
DrugDiclofenac sodium [15307-79-6]; Up 200; 12.6uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.40e-04198527215_UP
DrugPropantheline bromide [50-34-0]; Down 200; 9uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.40e-04198524798_DN
DrugSulfinpyrazone [57-96-5]; Up 200; 9.8uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.40e-04198526230_UP
DrugFluphenazine dihydrochloride [146-56-5]; Up 200; 7.8uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.47e-04199527234_UP
DrugAzaperone [1649-18-9]; Up 200; 12.2uM; MCF7; HT_HG-U133A

PCM1 SYBU

7.47e-04199527231_UP
Drugmercury

MAP4K4 CACNA1E

5.39e-0354252CID000023931
Diseaseepilepsy (implicated_via_orthology)

MAP4K4 CACNA1E

3.00e-0416352DOID:1826 (implicated_via_orthology)
Diseaseatopic asthma

RIC1 MAP4K4

4.47e-0419952EFO_0010638
Diseaseneuroticism measurement, cognitive function measurement

SYBU CACNA1E

3.53e-0356652EFO_0007660, EFO_0008354
DiseaseAlzheimer disease, polygenic risk score

SYBU CACNA1E

3.78e-0358652EFO_0030082, MONDO_0004975
Diseaseserum metabolite measurement

RIC1 CACNA1E

9.61e-0394552EFO_0005653
Diseasecortical surface area measurement

SYBU MAP4K4

1.89e-02134552EFO_0010736

Protein segments in the cluster

PeptideGeneStartEntry
IERDRRRRHHMSMWE

CACNA1E

746

Q15878
MMLWRHARRLLEDVR

RIC1

1061

Q4ADV7
AMLLECRWREMEEHR

MAP4K4

491

O95819
CRWREMEEHRQAERL

MAP4K4

496

O95819
ELWSEMRRHEMLREE

PCM1

821

Q15154
LARMREDWIEEECHR

SYBU

306

Q9NX95