Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenodelayed brain development

CDK13 NCOA6

9.56e-0511192MP:0001889
MousePhenoirregular heartbeat

CDK13 FOXP1 SCN1A

1.15e-0471193MP:0001636
MousePhenolethality during fetal growth through weaning, complete penetrance

ZFHX4 BIRC6 ARHGAP5 NUP50 CDK13 FOXP1 NCOA6 SCN1A

1.37e-041269198MP:0011111
MousePhenodecreased hepatocyte number

BIRC6 NCOA6

1.82e-0415192MP:0000606
MousePhenothin myocardium

CDK13 NCOA6 VCL

1.96e-0485193MP:0002652
MousePhenolethality throughout fetal growth and development

BIRC6 CDK13 FOXP1 NCOA6 SCN1A

2.31e-04435195MP:0006208
DomainIon_trans_dom

SCN1A KCNH5

7.19e-03114212IPR005821
DomainIon_trans

SCN1A KCNH5

7.19e-03114212PF00520
Pubmed

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.

FOXP1 GCGR

5.20e-06621228591638
Pubmed

N6 -methyladenosine-modified lncRNA ARHGAP5-AS1 stabilises CSDE1 and coordinates oncogenic RNA regulons in hepatocellular carcinoma.

ARHGAP5 METTL4

9.70e-06821236354136
Pubmed

Human transcription factor protein interaction networks.

ZFHX4 FOXP1 NCOA6 N4BP1 LIN54 VCL HERC2

1.36e-05142921735140242
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

KIAA1549 N4BP1 GORASP2 HNRNPM

1.73e-0526321434702444
Pubmed

Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.

BIRC6 ARHGAP5 FOXP1 VCL

1.94e-0527121425737280
Pubmed

Functional proteomics mapping of a human signaling pathway.

ARHGAP5 CDK13 NCOA6 VCL HERC2

2.26e-0559121515231748
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

KIAA1549 BIRC6 ARHGAP5 NUP50 GORASP2 HERC2

2.73e-05104921627880917
Pubmed

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

NUP50 N4BP1 LIN54 HNRNPM

4.66e-0533921430415952
Pubmed

Interaction network of human early embryonic transcription factors.

ZFHX4 FOXP1 NCOA6 LIN54

5.33e-0535121438297188
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

NUP50 NCOA6 LIN54

5.48e-0512321326912792
Pubmed

The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.

ZFHX4 FOXP1

6.55e-052021235177643
Pubmed

Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development.

FOXP1 VCL

7.24e-052121231680852
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ZFHX4 BIRC6 FOXP1 LIN54

1.05e-0441821434709266
Pubmed

Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.

NUP50 LIN54 HNRNPM

1.11e-0415621337108203
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

NCOA6 SCN1A WNK2 HNRNPM

1.17e-0443021435044719
Pubmed

Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders.

ZFHX4 FOXP1

1.30e-042821229365100
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

BIRC6 NUP50 N4BP1 GORASP2 VCL HNRNPM

1.67e-04145521622863883
Pubmed

Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons.

ZFHX4 FOXP1

1.70e-043221236596814
Pubmed

A human MAP kinase interactome.

CSN2 WNK2 HERC2 HNRNPM

1.87e-0448621420936779
Pubmed

A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection.

CSN2 VCL HERC2

1.95e-0418921331594818
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

NUP50 CDK13 GORASP2 HNRNPM

2.13e-0450321416964243
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

NUP50 CDK13 VCL HNRNPM

2.18e-0450621430890647
Pubmed

Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.

BIRC6 FOXP1 VCL

2.70e-042112137566098
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

ARHGAP5 N4BP1 GORASP2 VCL

3.31e-0456521425468996
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

NUP50 CDK13 FOXP1 NCOA6 LIN54

4.23e-04110321534189442
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

BIRC6 CDK13 NCOA6 WNK2 HERC2

4.27e-04110521535748872
Pubmed

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

BIRC6 VCL HERC2

4.28e-0424721332989298
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

VCL HERC2 HNRNPM

4.44e-0425021333536335
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

FOXP1 NCOA6 LIN54

5.43e-0426821333640491
InteractionERG interactions

ZFHX4 FOXP1 NCOA6 HERC2 HNRNPM

2.15e-06223205int:ERG
InteractionSP7 interactions

ZFHX4 FOXP1 NCOA6 N4BP1 LIN54

9.73e-06304205int:SP7
InteractionIPO11 interactions

BIRC6 NUP50 GCGR HERC2

1.64e-05159204int:IPO11
InteractionVSX1 interactions

ZFHX4 FOXP1 VCL

3.68e-0566203int:VSX1
InteractionPHIP interactions

ZFHX4 NUP50 FOXP1 VCL

3.80e-05197204int:PHIP
InteractionFEV interactions

ZFHX4 FOXP1 NCOA6 LIN54

4.27e-05203204int:FEV
InteractionB9D2 interactions

NUP50 LIN54 HNRNPM

4.97e-0573203int:B9D2
InteractionNFIX interactions

ZFHX4 FOXP1 LIN54 VCL

6.59e-05227204int:NFIX
InteractionTAF1 interactions

KIAA1549 NUP50 FOXP1 HERC2

1.11e-04260204int:TAF1
InteractionGTF2A1 interactions

NUP50 NCOA6 GORASP2

1.43e-04104203int:GTF2A1
InteractionTSC22D1 interactions

NUP50 GORASP2 HNRNPM

1.43e-04104203int:TSC22D1
InteractionTBXT interactions

ZFHX4 FOXP1 NCOA6

1.97e-04116203int:TBXT
InteractionELK3 interactions

ZFHX4 FOXP1 LIN54

2.18e-04120203int:ELK3
InteractionPAX9 interactions

ZFHX4 FOXP1 NCOA6

2.76e-04130203int:PAX9
InteractionCCNK interactions

NUP50 CDK13 HERC2

2.89e-04132203int:CCNK
InteractionPMCH interactions

BIRC6 HERC2

3.00e-0426202int:PMCH
InteractionNEK3 interactions

CSN2 CDK13

3.00e-0426202int:NEK3
InteractionNR2F2 interactions

NUP50 FOXP1 GCGR

3.36e-04139203int:NR2F2
InteractionTOP3B interactions

BIRC6 CDK13 NCOA6 GORASP2 WNK2 HERC2 HNRNPM

3.60e-041470207int:TOP3B
InteractionZNF148 interactions

NUP50 FOXP1 GORASP2

3.73e-04144203int:ZNF148
InteractionMYH10 interactions

BIRC6 FOXP1 HERC2 HNRNPM

3.83e-04359204int:MYH10
InteractionPAX6 interactions

ZFHX4 FOXP1 NCOA6 LIN54

4.12e-04366204int:PAX6
InteractionGCG interactions

GCGR HERC2

4.28e-0431202int:GCG
InteractionCCDC22 interactions

BIRC6 NUP50 HERC2

4.36e-04152203int:CCDC22
InteractionENOX2 interactions

GORASP2 VCL

4.56e-0432202int:ENOX2
InteractionSLFN11 interactions

NUP50 VCL HERC2 HNRNPM

4.56e-04376204int:SLFN11
InteractionACTC1 interactions

NUP50 CDK13 WNK2 VCL HNRNPM

4.81e-04694205int:ACTC1
InteractionAURKA interactions

CSN2 BIRC6 FOXP1 VCL HERC2

4.87e-04696205int:AURKA
InteractionCNTNAP2 interactions

SCN1A GORASP2 WNK2

4.89e-04158203int:CNTNAP2
InteractionSOX5 interactions

ZFHX4 FOXP1 LIN54

5.26e-04162203int:SOX5
InteractionSPSB3 interactions

BIRC6 CDK13

6.10e-0437202int:SPSB3
InteractionEGR2 interactions

ZFHX4 FOXP1 NCOA6

6.15e-04171203int:EGR2
InteractionUNK interactions

BIRC6 ARHGAP5 FOXP1 VCL

6.20e-04408204int:UNK
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ARHGAP5 PANK1 LIN54 METTL4

1.41e-06180214a682a5d55c612709c9ee9fa4289d6f8bef7fe1af
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ARHGAP5 FOXP1 METTL4

4.90e-051532137518187a5fbf6c0881182dc79bd37c2d49f92b2e
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ARHGAP5 FOXP1 METTL4

4.90e-0515321393d36723f01c2df39feebf20f3eba5b4fb4cdf59
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Pld5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZFHX4 FOXP1 KCNH5

5.50e-05159213a082e770fa757c4a1d3ed13d53f83297e36faf05
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Cbln4_Fezf2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZFHX4 FOXP1 KCNH5

5.60e-05160213d8241404d775f9a709abdf17988f36293fcf4c58
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_1|356C / Donor, Lineage, Cell class and subclass (all cells)

PANK1 LIN54 METTL4

7.06e-05173213e3cb7c8c09f937da6b8d673e9adfec5d94a15548
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

NUP50 N4BP1 GORASP2

7.31e-051752135f5fc1bf29f07e086951d4f9486b5f07bdcc5d4f
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

PANK1 LIN54 METTL4

7.56e-0517721336b5d29caa9cffbc0284f771a4db71aa72171a89
ToppCellmild-CD4+_Tcm|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ARHGAP5 FOXP1 N4BP1

1.07e-0419921306c8a0e39f7a33736548f04a5e2263334c8541cf
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

ZFHX4 KIAA1549 FOXP1

1.07e-04199213358c4b3037f59378db8916a2fbe9ed4830cf1449
Diseasenon-melanoma skin carcinoma

ZFHX4 FOXP1 NCOA6 HERC2

3.37e-05265214EFO_0009260
Diseaseactinic keratosis

FOXP1 HERC2

4.37e-0514212EFO_0002496
Diseasepuberty onset measurement

BIRC6 NCOA6 HERC2

9.33e-05125213EFO_0005677
DiseaseAlzheimer disease, gastroesophageal reflux disease

CDK13 FOXP1 KCNH5

5.46e-04228213EFO_0003948, MONDO_0004975
Diseasesquamous cell carcinoma

FOXP1 HERC2

1.04e-0367212EFO_0000707
Diseasesynophrys measurement

ZFHX4 HERC2

1.07e-0368212EFO_0007906
Diseaseaggressive behaviour measurement, ADHD symptom measurement

BIRC6 NCOA6

1.07e-0368212EFO_0007826, EFO_0007860
Diseaseage at menopause

ZFHX4 BIRC6 GORASP2

1.23e-03302213EFO_0004704
DiseaseAutism Spectrum Disorders

FOXP1 SCN1A

1.66e-0385212C1510586
Diseasesubcutaneous adipose tissue measurement

FOXP1 KCNH5

1.98e-0393212EFO_0004766
DiseaseNeurodevelopmental Disorders

FOXP1 SCN1A

1.98e-0393212C1535926
Diseasesleep duration

SCN1A KCNH5 METTL4

2.07e-03362213EFO_0005271
Diseasemean fractional anisotropy measurement

FOXP1 WNK2

2.07e-0395212EFO_0008399
Diseasecorpus callosum volume measurement

FOXP1 WNK2

2.29e-03100212EFO_0010299
DiseaseVitiligo

FOXP1 HERC2

2.33e-03101212EFO_0004208
Diseasesuntan

NCOA6 HERC2

2.43e-03103212EFO_0004279
DiseaseEpilepsy

SCN1A KCNH5

2.71e-03109212C0014544
Diseasekeratinocyte carcinoma

FOXP1 HERC2

3.17e-03118212EFO_0010176

Protein segments in the cluster

PeptideGeneStartEntry
LLDNLLSPLQPQLPM

BIRC6

2141

Q9NR09
QPPLLLPLLQPQLLQ

CDK13

36

Q14004
LGNILLNVLIPPNMP

NUP50

401

Q9UKX7
IQLIAMQPIPAPPVQ

KIAA1549

1486

Q9HCM3
QPQQRLIMPATPLPQ

LIN54

431

Q6MZP7
LIMPATPLPQIQPNL

LIN54

436

Q6MZP7
MPLPAGLPNLPNLNL

GORASP2

306

Q9H8Y8
PEGPQPPMILLQQLL

HERC2

2371

O95714
MITIPPSILNNPNIP

HNRNPM

176

P52272
QMPLQVPPQIPCQDI

KCNH5

956

Q8NCM2
QPALPLQPLAQGMIP

FOXP1

211

Q9H334
MPPCQPQRPLLLLLL

GCGR

1

P47871
QPVEQRPLQQMPPQL

NCOA6

976

Q14686
LPLPLLQPLMQQVPQ

CSN2

141

P05814
LQPLMQQVPQPIPQT

CSN2

146

P05814
PLQIQQIPIPKLAAP

METTL4

306

Q8N3J2
QRLPLLPELQPQPLL

PANK1

196

Q8TE04
MVPLQLPPPLQPQLI

ARHGAP5

1476

Q13017
EPPLNLPQPNKLQLI

SCN1A

1836

P35498
LPPQLALQLPQMDAL

ZFHX4

2046

Q86UP3
PELLLMPSNQPVNQP

VCL

951

P18206
KPLQMPQAPLQPLAQ

WNK2

776

Q9Y3S1
PLLPALPSLQQNLPM

N4BP1

831

O75113