Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessmonoubiquitinated protein deubiquitination

USP16 USP7 USP15

1.59e-05101073GO:0035520
GeneOntologyCellularComponentnuclear protein-containing complex

MYBBP1A INTS7 SYNE1 UBA2 UPF3A HEATR1 XRCC3 SFR1 BPTF GTF2E2 GTF2H1 PER2 NABP2 SUPT16H NUP133 PEX2 DHX35 TAF1 PRPF39 NXF1 VDR

6.54e-06137710821GO:0140513
DomainUSP7_C2

USP7 USP15

1.01e-0431092PF14533
DomainUSP_C

USP7 USP15

1.01e-0431092IPR029346
DomainARM-type_fold

MYBBP1A INTS7 ARFGEF2 HEATR1 FOCAD RIF1 INF2 EIF4G2

8.41e-043391098IPR016024
DomainLeu-rich_rpt

LRRC66 LRR1 NLRP14 FBXL2 LRMDA LRRD1 NXF1

1.06e-032711097IPR001611
DomainDNA/RNA_helicase_DEAH_CS

ERCC6L2 DHX35 DHX29

1.10e-03351093IPR002464
Domain-

SAMD9 ABCA13 ABCB5 PEX1 XRCC3 EHD2 NLRP14 ERCC6L2 DHX35 ABCD2 DNAH5 DHX29

1.36e-03746109123.40.50.300
DomainDEAH_ATP_HELICASE

ERCC6L2 DHX35 DHX29

1.41e-03381093PS00690
DomainAAA

ABCA13 ABCB5 PEX1 ABCD2 DNAH5

1.56e-031441095SM00382
DomainAAA+_ATPase

ABCA13 ABCB5 PEX1 ABCD2 DNAH5

1.56e-031441095IPR003593
DomainLRR_1

LRRC66 LRR1 FBXL2 LRMDA LRRD1 NXF1

1.80e-032191096PF00560
DomainABC_tran

ABCA13 ABCB5 ABCD2

2.76e-03481093PF00005
DomainABC_TRANSPORTER_2

ABCA13 ABCB5 ABCD2

2.76e-03481093PS50893
Domain-

LRRC66 LRR1 NLRP14 FBXL2 LRMDA LRRD1 NXF1

2.77e-0332110973.80.10.10
DomainABC_TRANSPORTER_1

ABCA13 ABCB5 ABCD2

2.93e-03491093PS00211
DomainABC_transporter-like

ABCA13 ABCB5 ABCD2

3.10e-03501093IPR003439
DomainL_dom-like

LRRC66 LRR1 NLRP14 FBXL2 LRMDA LRRD1 NXF1

3.12e-033281097IPR032675
DomainP-loop_NTPase

SAMD9 ABCA13 ABCB5 PEX1 XRCC3 EHD2 NLRP14 ERCC6L2 DHX35 ABCD2 DNAH5 DHX29

3.91e-0384810912IPR027417
DomainLRR_6

LRR1 NLRP14 FBXL2

4.07e-03551093PF13516
DomainDUF1605

DHX35 DHX29

4.33e-03171092IPR011709
DomainOB_NTP_bind

DHX35 DHX29

4.33e-03171092PF07717
DomainHA2

DHX35 DHX29

4.86e-03181092SM00847
DomainHA2

DHX35 DHX29

4.86e-03181092PF04408
DomainHelicase-assoc_dom

DHX35 DHX29

4.86e-03181092IPR007502
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

MYBBP1A CHAF1A UBA2 NSMCE3 PRDX6 EHD2 BPTF RIF1 GTF2E2 TRNT1 TKT EIF4G2 SUPT16H NUP133 USP7 TAF1 FKBP3 NXF1

3.19e-0910141101832416067
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

MYBBP1A GNE GPX8 FERMT1 OAS3 HEATR1 USP16 NGDN RIF1 GTF2H1 INF2 TKT SHCBP1 EIF4G2 SUPT16H NUP133 USP7 DHX29 NXF1

4.77e-0813531101929467282
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

SYNE1 HEATR1 NGDN INF2 TKT SUPT16H NUP133 USP7 DHX29 NXF1

1.11e-073321101025693804
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

MYBBP1A CHAF1A ARFGEF2 UBA2 NSMCE3 USP16 PACS1 BPTF RIF1 TKT SHCBP1 EIF4G2 USP7 DHX29

1.66e-077741101415302935
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

MYBBP1A HEATR1 USP16 PRDX6 GGA3 RIF1 GTF2E2 ALMS1 TKT KIAA1217 EIF4G2 NUP133 USP7 DHX29 FKBP3

2.67e-079341101533916271
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

SPAG1 RGSL1 ARV1 ABCB5 CEP290 WLS PRDX6 TTBK2 LMLN NOSTRIN FBXL2 DHX29 LRRD1

2.81e-076861101329987050
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

MYBBP1A CTDSPL2 INTS7 CHAF1A HEATR1 PHF2 BPTF RIF1 GTF2H1 SUPT16H TAF1

1.07e-065331101130554943
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

INTS7 NT5E MARK3 SYNE1 CHAF1A HEATR1 ANKZF1 NGDN PHF2 RIF1 GTF2E2 GTF2H1 MAN1A2 EIF4G2 USP7 DHX29 FKBP3 NXF1

1.08e-0614971101831527615
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

MYBBP1A CACNA2D2 SYNE1 CHAF1A HEATR1 PRDX6 PHF2 RIF1 TKT EIF4G2 SUPT16H NUP133 USP7 DNAH5 DHX29 FKBP3 NXF1

2.47e-0614251101730948266
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

MYBBP1A CHAF1A CEP290 USP16 BPTF ALMS1 SUPT16H NUP133 USP7 VDR

2.55e-064691101027634302
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

MYBBP1A SPAG1 CTDSPL2 PCDHGA10 SYNE1 ABCB5 CHAF1A HEATR1 NGDN BPTF TRNT1 TKT LMLN SUPT16H NOSTRIN LRMDA CFAP46

2.89e-0614421101735575683
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

MYBBP1A CTDSPL2 INTS7 CHAF1A CEP290 HEATR1 NGDN PHF2 BPTF RIF1 TMTC3 EIF4G2 SUPT16H NUP133 USP7 NXF1

3.20e-0612941101630804502
Pubmed

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.

MYBBP1A OAS3 PRDX6 EHD2 SUPT16H NUP133 USP7 FKBP3 NXF1

5.71e-06403110935253629
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

MYBBP1A MARK3 NUTM2A OAS3 ANKZF1 PRDX6 NGDN PHF2 RIF1 GTF2E2 TKT SUPT16H NOSTRIN PRPF39 FKBP3 NXF1

6.64e-0613711101636244648
Pubmed

Common genetic variants on 5p14.1 associate with autism spectrum disorders.

CDH9 CDH10

9.91e-062110219404256
Pubmed

Do PACS1 variants impeding adaptor protein binding predispose to syndromic intellectual disability?

GGA3 PACS1

9.91e-062110237141437
Pubmed

Analysis of four genes involved in the neurodevelopment shows association of rs4307059 polymorphism in the cadherin 9/10 region with completed suicide.

CDH9 CDH10

9.91e-062110222846907
Pubmed

Mechanism for recycling tRNAs on stalled ribosomes.

ANKZF1 TRNT1

9.91e-062110231011209
Pubmed

Functional interaction of general transcription initiation factor TFIIE with general chromatin factor SPT16/CDC68.

GTF2E2 SUPT16H

9.91e-062110210792464
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

MYBBP1A HEATR1 PRDX6 GGA3 BPTF GTF2E2 ALMS1 USP7 TAF1 USP15

1.01e-055491101038280479
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

MYBBP1A SAMD9 MARK3 OAS3 HEATR1 USP16 NGDN GTF2H1 TKT KIAA1217 SUPT16H NUP133 USP7 FKBP3 NXF1

1.02e-0512571101536526897
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

MYBBP1A CHAF1A NUTM2A HEATR1 NSMCE3 PHF2 BPTF RIF1 GTF2E2 EIF4G2 SUPT16H TAF1 FKBP3

1.05e-059541101336373674
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

CHAF1A UBA2 PRDX6 BPTF RIF1 EIF4G2 USP7 TAF1

1.12e-05332110832786267
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

SPAG1 MARK3 FERMT1 PRDX6 GGA3 NGDN KIAA1217 EIF4G2 USP15 DHX29

1.30e-055651101025468996
Pubmed

Deubiquitinating enzymes: a new class of biological regulators.

USP16 USP7 USP15

1.36e-051511039827704
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

PHF2 BPTF RIF1 GTF2H1 NUP133 DHX29 NXF1

1.55e-05250110733536335
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

MYBBP1A ARFGEF2 BPTF ALMS1 TKT SUPT16H NUP133 USP7 PRPF39

2.86e-05494110926831064
Pubmed

[Analysis of the association of polymorphic variants of SYP1A2, GSTT1,GSTM1, GSTP1, XRCC1, XRCC3, AR and VDR genes with predisposition to the development of prostate cancer].

XRCC3 VDR

2.97e-053110230695589
Pubmed

Dynamics of the Extended String-Like Interaction of TFIIE with the p62 Subunit of TFIIH.

GTF2E2 GTF2H1

2.97e-053110227602723
Pubmed

Ecto-5' -Nucleotidase CD73 (NT5E), vitamin D receptor and FGF23 gene polymorphisms may play a role in the development of calcific uremic arteriolopathy in dialysis patients - Data from the German Calciphylaxis Registry.

NT5E VDR

2.97e-053110228212442
Pubmed

USP15-USP7 Axis and UBE2T Differential Expression May Predict Pathogenesis and Poor Prognosis in De Novo Myelodysplastic Neoplasm.

USP7 USP15

2.97e-053110237373211
Pubmed

Role of IL6, IL12B and VDR gene polymorphisms in Plasmodium vivax malaria severity, parasitemia and gametocytemia levels in an Amazonian Brazilian population.

IL12B VDR

2.97e-053110224139871
Pubmed

Cadherins Interact With Synaptic Organizers to Promote Synaptic Differentiation.

CDH9 CDH10

2.97e-053110229760652
Pubmed

ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality Control.

ANKZF1 TRNT1

2.97e-053110232075755
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

MYBBP1A MARK3 HEATR1 NGDN BPTF RIF1 SUPT16H NUP133 DHX29 FKBP3 NXF1

2.99e-057591101135915203
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

MYBBP1A CHAF1A ANKZF1 RIF1 SHCBP1 NUP133 LRMDA USP15 DHX29

3.29e-05503110916964243
Pubmed

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation.

PHF2 GTF2H1 SUPT16H DHX35

3.77e-0559110434108663
Pubmed

Subunit-Specific Labeling of Ubiquitin Chains by Using Sortase: Insights into the Selectivity of Deubiquitinases.

USP7 USP15

5.92e-054110227256865
Pubmed

Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling.

CHAF1A UBA2

5.92e-054110225391492
Pubmed

Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus.

CDH9 CDH10

5.92e-054110228957665
Pubmed

In vivo phenotypic and molecular characterization of retinal degeneration in mouse models of three ciliopathies.

CEP290 ALMS1

5.92e-054110231302159
Pubmed

Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold.

CDH9 CDH10

5.92e-054110230197236
Pubmed

Properties of the ubiquitin-pex5p thiol ester conjugate.

PEX1 PEX2

5.92e-054110219208625
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

MYBBP1A CHAF1A HEATR1 PRDX6 NGDN BPTF RIF1 GTF2H1 TKT SUPT16H USP7 NXF1

7.15e-059891101236424410
Pubmed

USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.

USP7 USP15

9.85e-055110228126338
Pubmed

Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II.

GTF2E2 GTF2H1

9.85e-05511028152490
Pubmed

The carboxy terminus of the small subunit of TFIIE regulates the transition from transcription initiation to elongation by RNA polymerase II.

GTF2E2 GTF2H1

9.85e-055110212665589
Pubmed

Filamin A regulates neuronal migration through brefeldin A-inhibited guanine exchange factor 2-dependent Arf1 activation.

ARFGEF2 GGA3

9.85e-055110224089482
Pubmed

The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis.

GNE RIF1

9.85e-055110217118363
Pubmed

A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking.

GGA3 PACS1

9.85e-055110216977309
Pubmed

Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier.

URM1 USP15

9.85e-055110221209336
Pubmed

[A comparative analysis of tuberculosis susceptibility genetic make-up in Tuvinians and Russians].

IL12B VDR

9.85e-055110216637265
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

NSMCE3 USP16 PRDX6 NGDN TKT FER DHX35 DHX29 FKBP3 NXF1

1.04e-047241101036232890
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

MYBBP1A SYNE1 SUPT16H USP7 PPIP5K1 DNAH5

1.04e-04234110636243803
Pubmed

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.

USP16 RIF1 USP7 USP15 VPS53

1.08e-04147110529576527
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

MYBBP1A CHAF1A IRF6 XRCC3 NSMCE3 ANKZF1 PHF2 GTF2E2 GTF2H1 PER2 VDR

1.09e-048771101120211142
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

SAMD9 UBA2 HEATR1 PRDX6 BPTF RIF1 USP7 FKBP3

1.33e-04472110838943005
Pubmed

hHR23A is required to control the basal turnover of Chk1.

UBA2 USP7

1.47e-046110226296656
Pubmed

Sun exposure, vitamin D receptor gene polymorphisms and risk of non-Hodgkin lymphoma.

IL12B VDR

1.47e-046110217653830
Pubmed

[Influence of polymorphism of immune defense modifier genes on celiac disease development and various clinical features of disease in Tomsk population].

IL12B VDR

1.47e-046110218389618
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

MYBBP1A HEATR1 NGDN RIF1 TKT SUPT16H USP7 NXF1

1.55e-04483110836912080
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

MYBBP1A SFR1 BPTF RIF1

1.65e-0486110437253089
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

MYBBP1A MARK3 SYNE1 ARFGEF2 PRDX6 PACS1 GTF2E2 INF2 TKT KIAA1217 EIF4G2 USP7 PLCL1 DHX29

1.72e-0414311101437142655
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

SYNE1 ALMS1 TKT EIF4G2 SUPT16H NUP133 TAF1 NOSTRIN

1.89e-04497110823414517
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

MYBBP1A INTS7 GPX8 PEX1 HEATR1 WLS TMTC3 INF2 EIF4G2 NUP133 VPS53

2.02e-049421101131073040
Pubmed

BBS mutations modify phenotypic expression of CEP290-related ciliopathies.

CEP290 BBS7

2.06e-047110223943788
Pubmed

Characterization of cadherins expressed by murine thymocytes.

CDH9 CDH10

2.06e-04711028620560
Pubmed

A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction.

CDH9 CDH10

2.06e-04711028879495
Pubmed

The four murine peroxisomal ABC-transporter genes differ in constitutive, inducible and developmental expression.

PEX2 ABCD2

2.06e-047110210504404
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

MYBBP1A MARK3 CHAF1A UBA2 HEATR1 KCNIP2 TTBK2 TKT SHCBP1 EIF4G2 NUP133 USP7 USP15

2.14e-0412841101317353931
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

CHAF1A PEX1 OAS3 PHF2 BPTF GTF2H1 ALMS1 SLC25A43 SUPT16H USP7 TAF1 VPS53

2.20e-0411161101231753913
Pubmed

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.

INTS7 BPTF KIAA1217 SUPT16H USP7

2.56e-04177110526206133
Pubmed

The general transcription factors of RNA polymerase II.

GTF2E2 GTF2H1 TAF1

2.59e-043911038946909
Pubmed

Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes.

GTF2E2 GTF2H1 TAF1

2.59e-043911039054383
Pubmed

Three transitions in the RNA polymerase II transcription complex during initiation.

GTF2E2 GTF2H1 TAF1

2.59e-043911039405375
Pubmed

Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex.

UPF3A NXF1

2.74e-048110211546873
Pubmed

FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO.

GTF2H1 TAF1

2.74e-04811029765293
Pubmed

Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.

BPTF RIF1

2.74e-048110223143601
Pubmed

Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis.

SYCP2 USP7

2.74e-048110225634095
Pubmed

mSmile is necessary for bronchial smooth muscle and alveolar myofibroblast development.

CEP290 TMTC3

2.74e-048110221956870
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

MYBBP1A CHAF1A UBA2 HEATR1 USP16 PRDX6 NGDN PHF2 TRNT1 TKT SUPT16H PRPF39 NXF1

2.75e-0413181101330463901
Pubmed

ATP activates transcription initiation from promoters by RNA polymerase II in a reversible step prior to RNA synthesis.

GTF2E2 GTF2H1 TAF1

2.79e-044011032449431
Pubmed

Abortive initiation is increased only for the weakest members of a set of down mutants of the adenovirus 2 major late promoter.

GTF2E2 GTF2H1 TAF1

2.79e-044011031939271
Pubmed

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.

CTDSPL2 CHAF1A INF2

2.79e-0440110328805822
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

MYBBP1A SPAG1 GOLGA6L2 CEP290 HEATR1 PACS1 RIF1 GTF2H1 BBS7 SUPT16H NUP133 USP15 VPS53

2.81e-0413211101327173435
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

MYBBP1A BPTF RIF1 GTF2E2 SUPT16H TAF1

2.91e-04283110630585729
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

MYBBP1A SYNE1 NSMCE3 PACS1 TTBK2 PER2 INF2 TKT SHCBP1 NUP133 DHX35 NXF1

3.00e-0411551101220360068
Pubmed

VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.

ARFGEF2 HEATR1 RIF1 INF2 SUPT16H VPS53

3.19e-04288110623383273
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MARK3 SYNE1 GGA3 FOCAD PER2 PPIP5K1 USP15

3.23e-04407110712693553
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

CEP290 ALMS1 PER2 PPIP5K1

3.42e-0410411049205841
Pubmed

Transcription factor IIE binds preferentially to RNA polymerase IIa and recruits TFIIH: a model for promoter clearance.

GTF2E2 TAF1

3.52e-04911027926747
Pubmed

Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.

CDH9 CDH10

3.52e-049110223279374
Pubmed

The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.

USP16 USP7

3.52e-049110222195557
Pubmed

The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.

MYBBP1A SPAG1 GPX8 USP16 FER USP7 DHX29 NXF1

3.58e-04547110837267103
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

MYBBP1A UBA2 HEATR1 SUPT16H NUP133 DNAH5 PRPF39 DHX29 NXF1

4.09e-04704110929955894
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

MYBBP1A SYNE1 CEP290 HEATR1 PRDX6 BPTF RIF1 BBS7 SUPT16H NUP133 NXF1

4.10e-0410241101124711643
Pubmed

Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.

GTF2E2 GTF2H1 TAF1

4.23e-044611038849451
Pubmed

Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.

UPF3A NXF1

4.39e-0410110211546874
Pubmed

Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.

CDH9 CDH10

4.39e-0410110210861224
Pubmed

Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.

CDH9 CDH10

4.39e-041011022059658
Cytoband7q21.2

SAMD9 PEX1 LRRD1

5.80e-061510937q21.2
Cytoband12q21.32

CEP290 TMTC3

1.55e-048109212q21.32
Cytoband14q32.3

MARK3 XRCC3

2.48e-0410109214q32.3
Cytoband14q21.2

PRPF39 FKBP3

1.03e-0320109214q21.2
CytobandEnsembl 112 genes in cytogenetic band chr14q21

LRR1 PRPF39 FKBP3

1.63e-03971093chr14q21
GeneFamilyCD molecules|Type II classical cadherins

CDH9 CDH10

9.38e-04136421186
GeneFamilyUbiquitin specific peptidases

USP16 USP7 USP15

1.03e-0356643366
GeneFamilyDEAH-box helicases

DHX35 DHX29

1.43e-0316642500
GeneFamilyAAA ATPases|Peroxins

PEX1 PEX2

1.43e-0316642957
GeneFamilyBardet-Biedl syndrome associated|BBSome

CEP290 BBS7

2.48e-0321642980
GeneFamilyRho GTPase activating proteins|F-BAR domain containing

FER NOSTRIN

2.97e-03236421288
GeneFamilyGeneral transcription factors|Xeroderma pigmentosum complementation groups|DNA helicases|ERCC excision repair associated

GTF2E2 GTF2H1

3.51e-0325642565
CoexpressionAtlasDevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#5_top-relative-expression-ranked_1000

CTDSPL2 ARFGEF2 PEX1 RIF1 TRNT1 ERCC6L2 PRPF39

9.82e-061461087gudmap_developingKidney_e15.5_Cap mesenchyme_1000_k5
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

SPAG1 SAMD9 CEP290 USP16 BPTF MAN1A2 LMLN

6.06e-07199109761b1ed2db71b96157b92b7535d1955a4033098da
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRRC66 SAMD9 CACNA2D2 SHCBP1 FRMPD3 ABCD2

3.91e-06170109628fb192b21cdc5a77ba4f276694cff852eb2304b
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRRC66 SAMD9 CACNA2D2 SHCBP1 FRMPD3 ABCD2

3.91e-061701096239cb4b801b2d71a6facb386f2684c0851504151
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA2D2 WLS SLC9A2 PIEZO2 KIAA1217 CDH9

7.85e-061921096dc40ef2341e5d6a6d479f140e023fe1bf687928d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA2D2 WLS SLC9A2 PIEZO2 KIAA1217 CDH9

8.09e-061931096c7e9e6e4bf5e07c9cbdf1aa7c8828f4b2500e3ff
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA2D2 WLS SLC9A2 PIEZO2 KIAA1217 CDH9

8.09e-061931096d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA2D2 WLS SLC9A2 PIEZO2 KIAA1217 CDH9

8.09e-0619310962189da4b727e25e62669d7b9257f06493be21a27
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA2D2 WLS SLC9A2 PIEZO2 KIAA1217 CDH9

8.09e-0619310963ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCellmoderate-Epithelial-FOXN4+|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SPAG1 ABCA13 NT5E SYCP2 ALMS1 CFAP46

8.33e-0619410965dffa578149104dda33774361e9e77b227b5f1ce
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA2D2 WLS SLC9A2 PIEZO2 KIAA1217 CDH9

8.33e-0619410961bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

CEP290 USP16 BPTF MAN1A2 LMLN DHX29

9.36e-06198109676d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

CEP290 USP16 BPTF MAN1A2 TMTC3 DNAH5

9.63e-061991096fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

SAMD9 USP16 BPTF MAN1A2 DHX29 FKBP3

9.63e-061991096a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Stem_cells-neuroepithelial-like_cells|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

GNE CACNA2D2 INTS7 PLCL1 NOSTRIN

1.53e-0512710959071cd0953c8bb6746dc9cd13d153e3d6ef40b08
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Thalamus / BrainAtlas - Mouse McCarroll V32

SYT2 TNMD FRMPD3 CDH9 VDR

3.19e-051481095afebb64365c94b9476494bffe7c364677f19c8cf
ToppCellThalamus-Neuronal-Inhibitory|Thalamus / BrainAtlas - Mouse McCarroll V32

SYT2 TNMD FRMPD3 CDH9 VDR

3.19e-0514810955f82e5ecacfd223020b8ee975c17d68c1fe6db38
ToppCellNS-critical-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GNE GPX8 ABCA13 IRF6 EHD2

6.01e-051691095aec97583b23112060437b619cb429dc32f29285f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_KLHL14|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA2D2 WLS PIEZO2 KIAA1217 CDH9

8.75e-051831095439b1d1373b7cc73d65f3b59037a6def7cf8f4ba
ToppCellCOVID-19-kidney-PCT-S1|kidney / Disease (COVID-19 only), tissue and cell type

ABCA13 PLCL1 NOSTRIN LRMDA CDH9

8.97e-05184109551ed1ebfdef45149541917c66cbacad87072e51f
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA2D2 SLC9A2 PIEZO2 KIAA1217 CDH9

9.68e-05187109585f1678338a47d91e296f0620d4887f057eb7e70
ToppCellMS-CD8-CD4_Treg|MS / Condition, Cell_class and T cell subcluster

SPAG1 CTDSPL2 INTS7 TTPAL ANKZF1

9.93e-0518810952f0e2c7d79ee2d69a5d908c0247dc950c056c30a
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NT5E FERMT1 IRF6 CCL27 VDR

1.02e-0418910956f0fc5271a7d3682f145e734abc3be6473dda2e2
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NT5E FERMT1 IRF6 CCL27 VDR

1.02e-0418910953b9ce8964b16cb2200d30cbb0bfc711dcad2380e
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NT5E FERMT1 IRF6 CCL27 VDR

1.02e-04189109538acb307907fde68b992057714448c1561d69ee3
ToppCellNS-moderate-d_16-33-Epithelial-FOXN4+|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NT5E CHAF1A SYCP2 ALMS1 CFAP46

1.04e-041901095250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA2D2 WLS SLC9A2 KIAA1217 CDH9

1.12e-0419310952c15186d15545804cc262da9137ab825609d4b2c
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA2D2 WLS SLC9A2 KIAA1217 CDH9

1.12e-041931095010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA2D2 WLS SLC9A2 KIAA1217 CDH9

1.12e-041931095e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA2D2 WLS SLC9A2 PIEZO2 KIAA1217

1.15e-04194109583863da11dfbe59b2d0a2c08db40b537c150588c
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPAG1 ABCA13 SYNE1 DNAH5 CFAP46

1.15e-0419410954a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC60 SPAG1 ABCA13 DNAH5 CFAP46

1.18e-041951095d211a836cf711fdb91b10d512f09d462be937cc5
ToppCellLV-09._Endothelium_I|World / Chamber and Cluster_Paper

SYNE1 RBP7 KIAA1217 NOSTRIN LRMDA

1.18e-04195109519e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCellCOVID-19-Heart-EC_1|Heart / Disease (COVID-19 only), tissue and cell type

SYNE1 RBP7 KIAA1217 NOSTRIN LRMDA

1.18e-04195109550a193475db1bb1e05b8590225a553688c372c14
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

ABCA13 SYNE1 KIAA1217 DNAH5 CFAP46

1.21e-041961095af4cdc61830685a888a1209826c23bcf54a43084
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

ABCA13 SYNE1 KIAA1217 DNAH5 CFAP46

1.21e-0419610956d02d494196e3f857d53eea46d9419690d43beca
ToppCellmLN-B_cell-B_cell_cycling|mLN / Region, Cell class and subclass

SLC25A43 KIAA1217 LMLN SHCBP1 NUP133

1.24e-041971095806dddcca85c82bd642008d930c8db16b613d88e
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPAG1 ABCA13 SYNE1 DNAH5 CFAP46

1.24e-04197109591637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPAG1 ABCA13 SYNE1 DNAH5 CFAP46

1.24e-04197109522c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYNE1 CEP290 LMLN DNAH5 CFAP46

1.24e-04197109574a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellmLN-B_cell-B_cell_cycling|B_cell / Region, Cell class and subclass

SLC25A43 KIAA1217 LMLN SHCBP1 NUP133

1.24e-0419710952071526fe46de8359ea118ff78581eb4454aa55a
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPAG1 ABCA13 SYNE1 DNAH5 CFAP46

1.24e-0419710953bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Myeloid|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

RASSF2 OAS3 PRDX6 INF2 LMLN

1.24e-041971095179b56147cfb0a5f53c58615f2612b8ef68c8bb8
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPAG1 ABCA13 SYNE1 DNAH5 CFAP46

1.24e-04197109587db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCellmLN-(2)_B_cell-(24)_B_cell_cycling|mLN / shred on region, Cell_type, and subtype

SLC25A43 KIAA1217 LMLN SHCBP1 NUP133

1.24e-04197109570fff2d6723f259e18e7a21d22dc46d71f0759ce
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABCA13 CHAF1A IRF6 XRCC3 SHCBP1

1.27e-041981095f088badb90c6c2d916195f5649eda102119c9ac6
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

CEP290 USP16 BPTF MAN1A2 TMTC3

1.30e-041991095c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-|Neuronal / cells hierarchy compared to all cells using T-Statistic

SAMD9 WLS SLC9A2 PIEZO2 KIAA1217

1.33e-042001095a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-B3GAT2|Neuronal / cells hierarchy compared to all cells using T-Statistic

CACNA2D2 WLS SLC9A2 KIAA1217 CDH9

1.33e-042001095858421b91f5207b7934b5c219752cb9322a3da31
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

SAMD9 WLS SLC9A2 PIEZO2 KIAA1217

1.33e-04200109533b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-B3GAT2-|Neuronal / cells hierarchy compared to all cells using T-Statistic

CACNA2D2 WLS SLC9A2 KIAA1217 CDH9

1.33e-042001095a7022762c1d8aedb7b3e9605873b1e68b9907b35
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)|Neuronal / cells hierarchy compared to all cells using T-Statistic

CACNA2D2 WLS SLC9A2 PIEZO2 KIAA1217

1.33e-042001095347a510755374c6a66acee326565dfc447993f18
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6|Neuronal / cells hierarchy compared to all cells using T-Statistic

SAMD9 WLS SLC9A2 PIEZO2 KIAA1217

1.33e-0420010959719fabddc34051949468a7520289e3c750de4f8
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-B3GAT2--L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

CACNA2D2 WLS SLC9A2 KIAA1217 CDH9

1.33e-0420010952131c8e7fa054b79906eaf60536da892438b09cd
Diseaseblood rubidium measurement

ABCA13 ARFGEF2 RIF1

9.56e-05261013EFO_0021529
DiseasePEROXISOME BIOGENESIS DISORDER 3B

PEX1 PEX2

1.15e-0451012C3550693
DiseaseZellweger syndrome (implicated_via_orthology)

PEX1 PEX2

1.72e-0461012DOID:905 (implicated_via_orthology)
DiseaseLead Poisoning

XRCC3 VDR

2.41e-0471012C0023176
DiseasePeriventricular Nodular Heterotopia

ARFGEF2 TMTC3

2.41e-0471012C1868720
DiseaseDrug-induced agranulocytosis, response to clozapine

INTS7 TMTC3 CDH9

4.06e-04421013GO_0097338, HP_0012235
DiseasePEROXISOME BIOGENESIS DISORDER 1A (ZELLWEGER)

PEX1 PEX2

6.25e-04111012C4721541
DiseasePancreatic Ductal Adenocarcinoma

ABCB5 ABCD2

6.25e-04111012C1335302
DiseaseZellweger Spectrum

PEX1 PEX2

8.83e-04131012C3658299
DiseaseBardet-Biedl Syndrome

CEP290 ALMS1

8.83e-04131012C0752166
DiseaseInfantile Refsum Disease (disorder)

PEX1 PEX2

8.83e-04131012C0282527
DiseaseZellweger-Like Syndrome

PEX1 PEX2

8.83e-04131012C0751594
DiseaseIntellectual Disability

SYNE1 PACS1 BPTF BBS7 SUPT16H TAF1 VPS53

8.84e-044471017C3714756
Diseaseloneliness measurement

ARFGEF2 PHF2 BPTF PLCL1

8.86e-041241014EFO_0007865
DiseaseMalignant neoplasm of breast

SYNE1 ARFGEF2 XRCC3 GGA3 RIF1 SLC9A2 NLRP14 PER2 NUP133 CDH10 VDR

1.13e-03107410111C0006142
DiseaseGlobal developmental delay

CACNA2D2 SUPT16H TAF1 VPS53

1.15e-031331014C0557874
DiseasePeroxisome biogenesis disorders

PEX1 PEX2

1.18e-03151012C1832200
DiseaseAdrenoleukodystrophy, Neonatal

PEX1 PEX2

1.18e-03151012C0282525
DiseaseZellweger Syndrome

PEX1 PEX2

1.35e-03161012C0043459
Diseasebipolar I disorder

CACNA2D2 SYNE1 PACS1 TTBK2

1.42e-031411014EFO_0009963
DiseaseBardet-Biedl syndrome 1 (disorder)

CEP290 BBS7

1.53e-03171012C2936862
DiseaseBardet-Biedl syndrome

CEP290 BBS7

1.71e-03181012cv:C0752166
Diseaseleprosy, Crohn's disease

IL12B SLC9A2

2.12e-03201012EFO_0000384, EFO_0001054
Diseasealcohol drinking

OAS3 HEATR1 PLCL1

2.74e-03811013EFO_0004329
Diseaseaggressive behavior

SAMD9 ARFGEF2

3.31e-03251012EFO_0003015

Protein segments in the cluster

PeptideGeneStartEntry
EPLIKFQVGLKKLNL

VDR

311

P11473
PKLEYQLLLAKKVQL

BBS7

611

Q8IWZ6
QLYRKPLSDKLLRKV

CCL27

36

Q9Y4X3
ADKLLNILDPKKQLV

CTDSPL2

356

Q05D32
QILQVKLPISKLKDF

CACNA2D2

656

Q9NY47
KQLLELRKILFPKLV

ABCD2

86

Q9UBJ2
KQRLAIARALLQKPK

ABCB5

1161

Q2M3G0
NKKKQLILKLPVIFA

EHD2

326

Q9NZN4
KLADNLKLFRPKKLL

FERMT1

371

Q9BQL6
IELFNKKPKRGIQFL

ARFGEF2

651

Q9Y6D5
LPKRVFLAIQKNKPI

ALMS1

4096

Q8TCU4
INAFKILKKERPNRL

CFAP46

1706

Q8IYW2
EKKPKFEILLALLND

ABCA13

1481

Q86UQ4
KLIQARLPFKRLNLV

CHAF1A

31

Q13111
KPRDLFIAKLLNKLK

DHX29

486

Q7Z478
IFVLPNDDLKKLARK

BPTF

1846

Q12830
LKNFRPAKKILVKLQ

CCDC60

466

Q8IWA6
TPQVLKLLLNKFKIE

RASSF2

201

P50749
LLQYLKNDPRKAVKR

INTS7

256

Q9NVH2
FVKILQKLLKDGIQL

NUP133

1101

Q8WUM0
INKKLPKELLLRIFS

FBXL2

11

Q9UKC9
ILILDKNLLKNIPEK

LRRD1

376

A4D1F6
KLPNLKFLDAQKVTR

LRMDA

111

Q9H2I8
LDLSKNKIKALPVQF

LRR1

231

Q96L50
ELLPEKKNLVKNKLF

LMLN

106

Q96KR4
KLKALLPRLEQELKD

DCUN1D2

136

Q6PH85
REKLKLLQKLQPRFT

PER2

1166

O15055
NVKKLKDPTLRFRLL

NXF1

441

Q9UBU9
RKLPDTQLLKFQLNK

PCDHGA10

286

Q9Y5H3
FLLPLINVQKLKAKL

PEX2

206

P28328
TKKALKQRFLKLLPC

KCNIP2

31

Q9NS61
LKRKLERAKFLLPQV

GOLGA6L2

251

Q8N9W4
LLANPLKEKVRLRYK

GGA3

681

Q9NZ52
ILKDQKEPKNKTFLR

IL12B

116

P29460
FLFPLLKLEKELLKQ

EIF4G2

726

P78344
KFDVEVLKQLLKLLP

INF2

666

Q27J81
VKLARHLFKIQKNLP

PRPF39

496

Q86UA1
QKNLPKSRKVLLEAI

PRPF39

506

Q86UA1
RFPLLKVLILQRNKL

LRRC66

146

Q68CR7
ELFLLAQQKVPSKLK

MYBBP1A

216

Q9BQG0
RQPNIKQKFVALLKR

PACS1

326

Q6VY07
RKFLKSLIRKQPQEL

FAM118A

16

Q9NWS6
LKFLKSIDLQEPLQK

GNE

371

Q9Y223
KQRLKDKPLLSALDF

ANKZF1

101

Q9H8Y5
KKKPNFILLLKALLL

ARV1

171

Q9H2C2
FAALKRQRKKEPLIL

CDH10

631

Q9Y6N8
KFQLEQANKDLPRLK

CEP290

2076

O15078
DLPQELKIKFLQEAK

FER

596

P16591
KKEALLLIPNVLKVF

FRMPD3

171

Q5JV73
VREQLKKLLVKFQVP

DHX35

581

Q9H5Z1
NKLKKRFLRKPNVAE

F8A1;

31

P23610
RSEQLPKKDIIKFLQ

FKBP3

16

Q00688
RAFTKLLCPQKLKIQ

HRH3

421

Q9Y5N1
ENLLKRFLVLNPIKR

MARK3

281

P27448
IFKIKAVQLAEKLLP

MAN1A2

286

O60476
FLKLVPDLLAIVQRK

HEATR1

1641

Q9H583
QERKIPLKQLQEVKF

ERCC6L2

71

Q5T890
TLFLLQLKFLKPKIN

GPX8

31

Q8TED1
VLFAALKRQRKKEPL

CDH9

631

Q9ULB4
KDKNIFLLSPNLLQK

PEX1

511

O43933
KIFDLLPNKIRRKDL

FOCAD

1536

Q5VW36
IEEFNKKLNRPIKDL

DNAH5

1236

Q8TE73
LLKPKLLRLQRDIEK

NOSTRIN

301

Q8IVI9
FVNIRPAKLKNLILL

OAS3

191

Q9Y6K5
LVAPNLIERQKKVKL

IRF6

331

O14896
AQLVEKRLLPLKEKQ

NUTM2A

616

Q8IVF1
KLKEKLFNEINKIPL

SYT2

46

Q8N9I0
PKYNVRDKKALLRLL

GTF2E2

141

P29084
PFILILGNKKLKQIF

TAS2R30

276

P59541
PFILILGNKKLKQIF

TAS2R36

276

P0DTE0
EFLKERKAKIPLQFL

RGSL1

661

A5PLK6
RKAKIPLQFLTAVQK

RGSL1

666

A5PLK6
KKNLLKERPELFIQG

URM1

46

Q9BTM9
NLGLFIVKNRKDLIK

TRNT1

321

Q96Q11
FKPSQLIKDLAKEIR

PHF2

426

O75151
LKFLEGRKIKLVNIN

SYNE1

96

Q8NF91
LKPVLTQAKQKFLLL

RIF1

951

Q5UIP0
QLSPKEQRAFELKLK

SAMD9

856

Q5K651
VRRKSLVLKFPKQQL

TAF1

1336

P21675
PLLEYIKNRKLEKQR

UPF3A

216

Q9H1J1
KLAPEFAKRNVKLIA

PRDX6

56

P30041
KFPKKQLAALTQAIR

KIAA1217

1576

Q5T5P2
IFLNKQPNPRKKLLV

UBA2

416

Q9UBT2
SLQPQELRELKKFFK

SLC25A43

316

Q8WUT9
KQKLKLIENPLLRYV

SHCBP1

296

Q8NEM2
KLPKQRLNAEKAKLV

SFR1

146

Q86XK3
KLKDLYIRPNIAQKR

SUPT16H

661

Q9Y5B9
LLKEAKFPILSANIK

NT5E

131

P21589
FAIIKPFLKEKIANR

TTPAL

236

Q9BTX7
KPIENRDFLKNSKIL

TNMD

161

Q9H2S6
LNPTLKEAKIRLKFK

PLCL1

271

Q15111
AVKDLLQQLLPKFKR

GTF2H1

91

P32780
LQQLLPKFKRKANKE

GTF2H1

96

P32780
NLRKVNKHIKFPEIL

USP16

706

Q9Y5T5
LEKLRPLDQKLKYQI

NGDN

96

Q8NEJ9
LLKKEKINIRVLDPF

TKT

521

P29401
KYLRKLLIRENQPKS

SLC9A2

536

Q9UBY0
IDFATRKIAKLLKPQ

RBP7

26

Q96R05
DALRKNDFKPLKTLL

SYCP2

16

Q9BX26
FVKDIKPGLKNLNLI

NABP2

6

Q9BQ15
RLLNLKDKTAPFNKE

SPAG1

736

Q07617
PDLVKLLVEKRQFKS

TTBK2

976

Q6IQ55
DKLSFPLKNITRKNI

PIEZO2

2551

Q9H5I5
LNRIRKKPYIQLKDA

USP15

396

Q9Y4E8
NILDPRIKQEIIKKF

VPS53

246

Q5VIR6
ELVQFLLIKDQKKIP

NSMCE3

91

Q96MG7
PLAVLLQALLQFKRK

TTC37

1481

Q6PGP7
LLNIRLPVNEKKKIN

WLS

196

Q5T9L3
ALKKNFNRALELNPK

TMTC3

616

Q6ZXV5
ELNEQFKRKIKVVLP

SLC26A7

246

Q8TE54
LRDLLQFFKPRQPKK

USP7

861

Q93009
FDLLIPKNNCERKKI

ZNF605

106

Q86T29
LDLNPRIIAAIKKAK

XRCC3

6

O43542
GKLKLKRPEQLQEVL

PPIP5K1

431

Q6PFW1
NCKLQKLLLKFITFP

NLRP14

701

Q86W24