Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	microtubule binding	MAP6 APC MAP10 TTBK2 KIF9 HOOK3 KIF3B MACF1 RP1	4.20e-05	308	107	9	GO:0008017
GeneOntologyMolecularFunction	ATP-dependent activity	DNAH3 ABCC4 HYOU1 MYH13 EP400 CHD7 SRCAP KIF9 KIF3B ATP2C2 MACF1 ATP1A4	1.11e-04	614	107	12	GO:0140657
GeneOntologyMolecularFunction	Rho GDP-dissociation inhibitor binding	PLXNB3 RAC1	1.69e-04	4	107	2	GO:0051022
GeneOntologyMolecularFunction	tubulin binding	MAP6 APC MAP10 TTBK2 KIF9 HOOK3 KIF3B MACF1 RP1	4.94e-04	428	107	9	GO:0015631
GeneOntologyMolecularFunction	pyrophosphatase activity	DNAH3 ABCC4 CHD7 SRCAP KIF9 KIF3B ATP2C2 EIF5B MACF1 ATP1A4 RAC1 RAC3 DCP1A	5.47e-04	839	107	13	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	DNAH3 ABCC4 CHD7 SRCAP KIF9 KIF3B ATP2C2 EIF5B MACF1 ATP1A4 RAC1 RAC3 DCP1A	5.54e-04	840	107	13	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	DNAH3 ABCC4 CHD7 SRCAP KIF9 KIF3B ATP2C2 EIF5B MACF1 ATP1A4 RAC1 RAC3 DCP1A	5.54e-04	840	107	13	GO:0016818
GeneOntologyMolecularFunction	GDP-dissociation inhibitor binding	PLXNB3 RAC1	5.87e-04	7	107	2	GO:0051021
GeneOntologyMolecularFunction	ATP hydrolysis activity	DNAH3 ABCC4 CHD7 SRCAP KIF9 KIF3B ATP2C2 MACF1 ATP1A4	6.12e-04	441	107	9	GO:0016887
GeneOntologyMolecularFunction	transcription coregulator activity	NR3C1 SRCAP JMJD1C LPIN1 YEATS2 TSC22D1 PARP9 TRIM38 KDM1A NPAT	8.78e-04	562	107	10	GO:0003712
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	DNAH3 ABCC4 CHD7 SRCAP KIF9 KIF3B ATP2C2 EIF5B MACF1 ATP1A4 RAC1 RAC3	9.09e-04	775	107	12	GO:0017111
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	EP400 CHD7 SRCAP	1.02e-03	37	107	3	GO:0140658
GeneOntologyMolecularFunction	transcription coactivator activity	NR3C1 SRCAP LPIN1 TSC22D1 TRIM38 KDM1A NPAT	1.24e-03	303	107	7	GO:0003713
GeneOntologyBiologicalProcess	regulation of microtubule-based process	MAP6 APC XPO1 MAP10 TTBK2 KIF9 IGBP1 MACF1 RP1 WDR62 RAC1	3.01e-07	293	105	11	GO:0032886
GeneOntologyBiologicalProcess	forebrain development	CHD7 SLC7A11 TYRO3 TTBK2 HOOK3 PTPRS LRP2 VPS13B CNTN2 KDM1A WDR62 RAC1 RAC3	1.22e-06	489	105	13	GO:0030900
GeneOntologyBiologicalProcess	axonogenesis	TRIO MAP6 EMB APC NRXN3 PTPRS LRP2 MACF1 CNTN2 PLXNB3 VCL RAC1 RAC3	6.06e-06	566	105	13	GO:0007409
GeneOntologyBiologicalProcess	cerebral cortex GABAergic interneuron development	CNTN2 RAC1 RAC3	7.05e-06	8	105	3	GO:0021894
GeneOntologyBiologicalProcess	cerebral cortex GABAergic interneuron differentiation	CNTN2 RAC1 RAC3	2.05e-05	11	105	3	GO:0021892
GeneOntologyBiologicalProcess	axon development	TRIO MAP6 EMB APC NRXN3 PTPRS LRP2 MACF1 CNTN2 PLXNB3 VCL RAC1 RAC3	2.30e-05	642	105	13	GO:0061564
GeneOntologyBiologicalProcess	microtubule-based process	DNAH3 MAP6 APC XPO1 MAP10 TTBK2 KIF9 IGBP1 HOOK3 KIF3B MACF1 RP1 ATP1A4 CNTN2 WDR62 RAC1 AURKB	2.37e-05	1058	105	17	GO:0007017
GeneOntologyBiologicalProcess	brain development	ABR CHD7 ATXN1L SLC7A11 TYRO3 TTBK2 HOOK3 PTPRS LRP2 VPS13B CNTN2 KDM1A WDR62 RAC1 RAC3	2.93e-05	859	105	15	GO:0007420
GeneOntologyBiologicalProcess	central nervous system development	POU6F2 ABR CHD7 NR3C1 ATXN1L SLC7A11 TYRO3 TTBK2 HOOK3 PTPRS EIF2B1 LRP2 VPS13B CNTN2 KDM1A WDR62 RAC1 RAC3	3.20e-05	1197	105	18	GO:0007417
GeneOntologyBiologicalProcess	neuron projection morphogenesis	TRIO MAP6 EMB APC NRXN3 PTPRS LRP2 MACF1 CNTN2 KDM1A PLXNB3 VCL RAC1 RAC3	5.56e-05	802	105	14	GO:0048812
GeneOntologyBiologicalProcess	head development	ABR CHD7 ATXN1L SLC7A11 TYRO3 TTBK2 HOOK3 PTPRS LRP2 VPS13B CNTN2 KDM1A WDR62 RAC1 RAC3	6.33e-05	919	105	15	GO:0060322
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	TRIO MAP6 EMB APC NRXN3 PTPRS LRP2 MACF1 CNTN2 KDM1A PLXNB3 VCL RAC1 RAC3	6.96e-05	819	105	14	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	TRIO MAP6 EMB APC NRXN3 PTPRS LRP2 MACF1 CNTN2 KDM1A PLXNB3 VCL RAC1 RAC3	7.62e-05	826	105	14	GO:0048858
GeneOntologyBiologicalProcess	neuron projection development	TRIO MAP6 EMB APC NR3C1 NRXN3 TENM3 PTPRS LRP2 MACF1 PREX1 VPS13B CNTN2 KDM1A PLXNB3 VCL RAC1 RAC3	8.03e-05	1285	105	18	GO:0031175
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	TRIO MAP6 EMB APC NRXN3 PTPRS LRP2 MACF1 CNTN2 PLXNB3 VCL RAC1 RAC3	1.09e-04	748	105	13	GO:0048667
GeneOntologyBiologicalProcess	neuron development	TRIO MAP6 EMB APC NR3C1 NRXN3 TENM3 PTPRS LRP2 MACF1 RP1 PREX1 VPS13B CNTN2 KDM1A PLXNB3 VCL RAC1 RAC3	1.35e-04	1463	105	19	GO:0048666
GeneOntologyBiologicalProcess	female genitalia development	CHD7 TYRO3 LRP2	1.37e-04	20	105	3	GO:0030540
GeneOntologyBiologicalProcess	regulation of glutamate metabolic process	APC SLC7A11	1.53e-04	4	105	2	GO:2000211
GeneOntologyBiologicalProcess	GABAergic neuron differentiation	CNTN2 RAC1 RAC3	2.40e-04	24	105	3	GO:0097154
GeneOntologyBiologicalProcess	cAMP metabolic process	PDE10A ADCY2 ADCY5	2.72e-04	25	105	3	GO:0046058
GeneOntologyBiologicalProcess	telencephalon development	CHD7 SLC7A11 PTPRS VPS13B CNTN2 KDM1A WDR62 RAC1	2.98e-04	332	105	8	GO:0021537
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	MAP6 APC XPO1 MAP10 TTBK2 HOOK3 KIF3B RP1 CNTN2 WDR62 RAC1 AURKB	2.99e-04	720	105	12	GO:0000226
GeneOntologyBiologicalProcess	cell morphogenesis	TRIO MAP6 EMB APC JMJD1C NRXN3 PTPRS LRP2 MACF1 CDH8 CNTN2 KDM1A PLXNB3 VCL RAC1 RAC3	3.44e-04	1194	105	16	GO:0000902
GeneOntologyBiologicalProcess	cerebral cortex neuron differentiation	CNTN2 RAC1 RAC3	4.25e-04	29	105	3	GO:0021895
GeneOntologyCellularComponent	microtubule	DNAH3 MAP6 APC MAP10 KIF9 IGBP1 HOOK3 KIF3B MACF1 RP1 AURKB	9.10e-05	533	107	11	GO:0005874
GeneOntologyCellularComponent	somatodendritic compartment	ABR MAP6 APC NR3C1 PDE10A ATXN1L ADCY2 KHSRP ITPR3 KIF3B PTPRS LRP2 PREX1 CNTN2 RAC1 RAC3 DCP1A	1.62e-04	1228	107	17	GO:0036477
GeneOntologyCellularComponent	polymeric cytoskeletal fiber	DNAH3 MAP6 APC MAP10 KIF9 IGBP1 HOOK3 KIF3B MACF1 RP1 VCL RAC1 RAC3 AURKB	1.98e-04	899	107	14	GO:0099513
GeneOntologyCellularComponent	supramolecular fiber	DNAH3 MYH13 MAP6 APC MAP10 KIF9 IGBP1 HOOK3 KIF3B MACF1 RP1 VCL RAC1 RAC3 AHNAK2 AURKB	3.21e-04	1179	107	16	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	DNAH3 MYH13 MAP6 APC MAP10 KIF9 IGBP1 HOOK3 KIF3B MACF1 RP1 VCL RAC1 RAC3 AHNAK2 AURKB	3.46e-04	1187	107	16	GO:0099081
GeneOntologyCellularComponent	dendrite	ABR MAP6 APC NR3C1 ATXN1L ADCY2 KHSRP ITPR3 KIF3B LRP2 PREX1 RAC1 DCP1A	4.40e-04	858	107	13	GO:0030425
GeneOntologyCellularComponent	dendritic tree	ABR MAP6 APC NR3C1 ATXN1L ADCY2 KHSRP ITPR3 KIF3B LRP2 PREX1 RAC1 DCP1A	4.50e-04	860	107	13	GO:0097447
GeneOntologyCellularComponent	glutamatergic synapse	ABR TRIO APC NR3C1 PDE10A NRXN3 KIF3B TENM3 PTPRS CDH8 RAC1 RAC3	9.67e-04	817	107	12	GO:0098978
Domain	HSA	EP400 SRCAP	1.94e-04	4	107	2	SM00573
Domain	HSA	EP400 SRCAP	1.94e-04	4	107	2	PS51204
Domain	HSA_dom	EP400 SRCAP	1.94e-04	4	107	2	IPR014012
Domain	HSA	EP400 SRCAP	1.94e-04	4	107	2	PF07529
Domain	NUT	NUTM2A NUTM2B	3.22e-04	5	107	2	IPR024310
Domain	NUT_N	NUTM2A NUTM2B	3.22e-04	5	107	2	IPR024309
Domain	NUT	NUTM2A NUTM2B	3.22e-04	5	107	2	PF12881
Domain	Adcy_conserved_dom	ADCY2 ADCY5	4.80e-04	6	107	2	IPR009398
Domain	DUF1053	ADCY2 ADCY5	4.80e-04	6	107	2	PF06327
Domain	SNF2_N	EP400 CHD7 SRCAP	8.03e-04	32	107	3	IPR000330
Domain	SNF2_N	EP400 CHD7 SRCAP	8.03e-04	32	107	3	PF00176
Domain	AC_N	ADCY2 ADCY5	8.90e-04	8	107	2	IPR032628
Domain	Adcy	ADCY2 ADCY5	8.90e-04	8	107	2	IPR030672
Domain	AC_N	ADCY2 ADCY5	8.90e-04	8	107	2	PF16214
Domain	HAD-like_dom	NT5C3B LPIN1 ATP2C2 ATP1A4	1.10e-03	79	107	4	IPR023214
Domain	GDS_CDC24_CS	ABR TRIO PREX1	1.44e-03	39	107	3	IPR001331
Domain	Rho_GTPase_activation_prot	ABR ARHGAP11A PLXNB3 ARAP2	1.64e-03	88	107	4	IPR008936
Domain	TIL_dom	ZAN LRP2	2.83e-03	14	107	2	IPR002919
Domain	ATPase_P-typ_TM_dom	ATP2C2 ATP1A4	3.70e-03	16	107	2	IPR023298
Domain	-	ATP2C2 ATP1A4	3.70e-03	16	107	2	1.20.1110.10
Domain	ATPase_P-typ_cation-transptr_C	ATP2C2 ATP1A4	4.18e-03	17	107	2	IPR006068
Domain	A/G_cyclase_CS	ADCY2 ADCY5	4.18e-03	17	107	2	IPR018297
Domain	Cation_ATPase_C	ATP2C2 ATP1A4	4.18e-03	17	107	2	PF00689
Domain	Cation_ATPase_N	ATP2C2 ATP1A4	4.69e-03	18	107	2	PF00690
Domain	-	ADCY2 ADCY5	4.69e-03	18	107	2	3.30.70.1230
Domain	Cation_ATPase_N	ATP2C2 ATP1A4	4.69e-03	18	107	2	SM00831
Domain	Nucleotide_cyclase	ADCY2 ADCY5	4.69e-03	18	107	2	IPR029787
Domain	Ig_I-set	TRIO EMB TYRO3 PTPRS CNTN2	4.76e-03	190	107	5	IPR013098
Domain	I-set	TRIO EMB TYRO3 PTPRS CNTN2	4.76e-03	190	107	5	PF07679
Domain	Guanylate_cyc	ADCY2 ADCY5	5.22e-03	19	107	2	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY2 ADCY5	5.22e-03	19	107	2	PS50125
Domain	A/G_cyclase	ADCY2 ADCY5	5.22e-03	19	107	2	IPR001054
Domain	GUANYLATE_CYCLASE_1	ADCY2 ADCY5	5.22e-03	19	107	2	PS00452
Domain	ATPase_P-typ_cation-transptr_N	ATP2C2 ATP1A4	5.22e-03	19	107	2	IPR004014
Domain	CYCc	ADCY2 ADCY5	5.22e-03	19	107	2	SM00044
Domain	RhoGAP	ABR ARHGAP11A ARAP2	5.41e-03	62	107	3	SM00324
Domain	RhoGAP	ABR ARHGAP11A ARAP2	5.66e-03	63	107	3	PF00620
Domain	DH_1	ABR TRIO PREX1	5.66e-03	63	107	3	PS00741
Pathway	PID_RAC1_REG_PATHWAY	ABR TRIO DOCK6 PREX1 RAC1	2.70e-06	38	83	5	M241
Pathway	REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION	JMJD1C KIF9 KIF3B DOCK6 KDM1A RAC1	6.14e-05	116	83	6	MM15715
Pathway	WP_MICROTUBULE_CYTOSKELETON_REGULATION	TRIO APC RAC1 AURKB	1.78e-04	48	83	4	M39566
Pathway	REACTOME_RAC3_GTPASE_CYCLE	ABR TRIO PREX1 ARAP2 RAC3	2.17e-04	93	83	5	MM15609
Pathway	REACTOME_RAC3_GTPASE_CYCLE	ABR TRIO PREX1 ARAP2 RAC3	2.28e-04	94	83	5	M41818
Pathway	REACTOME_CDC42_GTPASE_CYCLE	ABR TRIO DOCK6 PREX1 ARAP2	2.28e-04	94	83	5	MM15598
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	ABR TRIO PREX1 RAC1	2.44e-04	52	83	4	MM14743
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	HYOU1 EP400 TRIO WDR70 APC CHD7 MCM10 JMJD1C YEATS2 ZC3H7A IGF2R EIF2B1 VCL WDR62 ZNF687 DCP1A	1.09e-09	733	108	16	34672954
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EP400 SF3A1 WDR70 ETFA NR3C1 SRCAP LDHB KHSRP YEATS2 IGBP1 KIAA1217 EIF5B MACF1 VCL WDR62 DCP1A AHNAK2	4.76e-09	934	108	17	33916271
Pubmed	RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways.	APC RAC1 RAC3	2.91e-08	3	108	3	33879799
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	APC CHD7 JMJD1C YEATS2 ZFHX4 LRP2 KDM1A WDR62 ZNF687 DCP1A NPAT	8.05e-08	418	108	11	34709266
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	EP400 RALGAPB ADCY2 YEATS2 KIF3B TENM3 MACF1 VPS13B PLXNB3 ARAP2	6.03e-07	407	108	10	12693553
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	ABR TRIO SF3A1 XPO1 ARHGAP11A SRFBP1 LDHB DOCK6 PREX1 KDM1A RAC1 ARAP2 RAC3 AURKB	9.88e-07	916	108	14	32203420
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	EP400 SF3A1 SRCAP JMJD1C DARS2 KHSRP EIF5B ZNF687 DCP1A	1.26e-06	341	108	9	32971831
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	SP2 EP400 WDR70 NR3C1 MCM10 JMJD1C YEATS2 IGBP1 DCP1A AHNAK2	1.32e-06	444	108	10	34795231
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	HYOU1 MAP6 APC CHD7 FCHO2 SRCAP ATXN1L TTBK2 IGF2R LRP2 MACF1 SPTY2D1 VPS13B DCP1A NPAT	1.35e-06	1084	108	15	11544199
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	HYOU1 SF3A1 XPO1 KHSRP EIF5B VCL DCP1A	1.53e-06	179	108	7	36261009
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ABR TRIO MAP6 APC CHD7 KHSRP HOOK3 IGF2R KIF3B PTPRS KIAA1217 MACF1 KDM1A RAC1	1.77e-06	963	108	14	28671696
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	EP400 APC CHD7 NR3C1 SRCAP LDHB YEATS2 ZC3H7A KIAA1217 MACF1 KDM1A	2.31e-06	588	108	11	38580884
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	EP400 SF3A1 WDR70 NR3C1 JMJD1C DARS2 KHSRP ZFHX4 NFYA EIF5B KDM1A RAC1 DCP1A	2.69e-06	857	108	13	25609649
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	HYOU1 HECTD3 SF3A1 ETFA RALGAPB NR3C1 DARS2 ITPR3 ZC3H7A IGF2R SIK2 EIF5B MACF1 VPS13B VCL WDR62 NPAT	3.36e-06	1487	108	17	33957083
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	HYOU1 EP400 SF3A1 ETFA XPO1 SRCAP KHSRP ITPR3 HOOK3 IGF2R EIF5B MACF1 KDM1A AURKB	3.61e-06	1024	108	14	24711643
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	HECTD3 ETFA CHD7 NR3C1 ADCY2 ITPR3 YEATS2 TTBK2 PREX1 ZNF687 AHNAK2	5.02e-06	638	108	11	31182584
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	HYOU1 SF3A1 CHD7 XPO1 KHSRP ITPR3 IGF2R EIF5B MACF1 KDM1A VCL	6.25e-06	653	108	11	22586326
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	HYOU1 EP400 SF3A1 CHD7 XPO1 ATXN1L LDHB JMJD1C KHSRP YEATS2 EIF5B KDM1A RAC1 ZNF687	8.39e-06	1103	108	14	34189442
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	CHD7 MAP10 JMJD1C DOCK6 PREX1 ZNF687	8.69e-06	153	108	6	10718198
Pubmed	Silencing Rac1 and Prex1 Inhibit Epithelial-Mesenchymal Transition in Human Gastric Cancer Cells Induced by Transforming Growth Factor-β1.	PREX1 RAC1	9.55e-06	2	108	2	37434402
Pubmed	PDE10A and ADCY5 mutations linked to molecular and microstructural basal ganglia pathology.	PDE10A ADCY5	9.55e-06	2	108	2	30345538
Pubmed	Rac-deficient cerebellar granule neurons die before they migrate to the internal granule layer.	RAC1 RAC3	9.55e-06	2	108	2	36050459
Pubmed	Rac1 and Rac3 have opposite functions in Schwann cells during developmental myelination.	RAC1 RAC3	9.55e-06	2	108	2	33812927
Pubmed	Identification of a Protein Network Driving Neuritogenesis of MGE-Derived GABAergic Interneurons.	RAC1 RAC3	9.55e-06	2	108	2	28066185
Pubmed	Pharmacological Inhibition of P-Rex1/Rac1 Axis Blocked Angiotensin II-Induced Cardiac Fibrosis.	PREX1 RAC1	9.55e-06	2	108	2	36892683
Pubmed	LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation.	NR3C1 KDM1A	9.55e-06	2	108	2	29618057
Pubmed	Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s.	ADCY2 ADCY5	9.55e-06	2	108	2	18164588
Pubmed	Dispensable role of Rac1 and Rac3 after cochlear hair cell specification.	RAC1 RAC3	9.55e-06	2	108	2	37204479
Pubmed	Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons.	RAC1 RAC3	9.55e-06	2	108	2	31369617
Pubmed	Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism.	KDM1A VCL	9.55e-06	2	108	2	35856020
Pubmed	P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac.	PREX1 RAC1	9.55e-06	2	108	2	11955434
Pubmed	Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis.	PREX1 RAC1	9.55e-06	2	108	2	18502673
Pubmed	A Rac1-independent role for P-Rex1 in melanoblasts.	PREX1 RAC1	9.55e-06	2	108	2	25075639
Pubmed	The catalytic subunit of the SWR1 remodeler is a histone chaperone for the H2A.Z-H2B dimer.	EP400 SRCAP	9.55e-06	2	108	2	24507717
Pubmed	Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1.	TRIO RAC1	9.55e-06	2	108	2	35779635
Pubmed	Rac1 and Rac3 GTPases regulate the development of hilar mossy cells by affecting the migration of their precursors to the hilus.	RAC1 RAC3	9.55e-06	2	108	2	21949760
Pubmed	Loss of Either Rac1 or Rac3 GTPase Differentially Affects the Behavior of Mutant Mice and the Development of Functional GABAergic Networks.	RAC1 RAC3	9.55e-06	2	108	2	26582364
Pubmed	The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion.	TRIO RAC1	9.55e-06	2	108	2	22238672
Pubmed	Rac-Dependent Signaling from Keratinocytes Promotes Differentiation of Intradermal White Adipocytes.	RAC1 RAC3	9.55e-06	2	108	2	31351086
Pubmed	Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion.	RAC1 RAC3	9.55e-06	2	108	2	16027728
Pubmed	The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.	PREX1 RAC1	9.55e-06	2	108	2	26112412
Pubmed	Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells.	RAC1 RAC3	9.55e-06	2	108	2	16280046
Pubmed	RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells.	RAC1 RAC3	9.55e-06	2	108	2	36599922
Pubmed	LSD1 inhibition circumvents glucocorticoid-induced muscle wasting of male mice.	NR3C1 KDM1A	9.55e-06	2	108	2	38670969
Pubmed	Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development.	RAC1 RAC3	9.55e-06	2	108	2	21469092
Pubmed	Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells.	RAC1 RAC3	9.55e-06	2	108	2	17244648
Pubmed	Opposite Modulation of RAC1 by Mutations in TRIO Is Associated with Distinct, Domain-Specific Neurodevelopmental Disorders.	TRIO RAC1	9.55e-06	2	108	2	32109419
Pubmed	Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo.	RAC1 RAC3	9.55e-06	2	108	2	25824687
Pubmed	E3 ubiquitin ligase HECTD3 is a tumor suppressor and mediates the polyubiquitination of SLC7A11 to promote ferroptosis in colon cancer.	HECTD3 SLC7A11	9.55e-06	2	108	2	37422058
Pubmed	Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.	APC PDE10A	9.55e-06	2	108	2	24704829
Pubmed	Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons.	CNTN2 RAC1 RAC3	1.03e-05	14	108	3	17409253
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	EP400 MCM10 JMJD1C YEATS2 KDM1A ZNF687 AURKB NPAT	1.13e-05	339	108	8	30415952
Pubmed	Trio controls the mature organization of neuronal clusters in the hindbrain.	TRIO CDH8 RAC1	1.29e-05	15	108	3	17898204
Pubmed	Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood-brain barrier disruption.	PDE10A LPIN1 IGF2R	1.29e-05	15	108	3	24090483
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	ABR HYOU1 SF3A1 APC XPO1 FCHO2 JMJD1C IGF2R EIF5B MACF1 VCL	1.33e-05	708	108	11	39231216
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	HYOU1 TRIO ETFA APC FCHO2 ZC3H7A HOOK3 IGF2R KIAA1217 LRP2 VCL WDR62	1.42e-05	853	108	12	28718761
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ABCC4 POU6F2 ABR TRIO WDR70 RALGAPB PDE10A JMJD1C YEATS2 TSC22D1 ZNF33B PTPRS KIAA1217 MACF1 DOCK6 VPS13B	1.45e-05	1489	108	16	28611215
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	APC DARS2 ITPR3 LPIN1 KIAA1217 MACF1 DCP1A AHNAK2	1.75e-05	360	108	8	33111431
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	RALGAPB YEATS2 KIAA1217 MACF1 PLXNB3	1.81e-05	103	108	5	10574462
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	HYOU1 APC JMJD1C KIAA1217 MACF1 VPS13B AHNAK2	1.90e-05	263	108	7	34702444
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	EP400 WDR70 CHD7 XPO1 MCM10 SRCAP LDHB KHSRP ZC3H7A EIF5B MACF1 KDM1A VCL DCP1A AHNAK2	1.93e-05	1353	108	15	29467282
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	WDR70 CHD7 MCM10 SRCAP ARHGAP11A JMJD1C KDM1A RAC1 AURKB NPAT	2.07e-05	608	108	10	36089195
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	HYOU1 SF3A1 ETFA XPO1 NR3C1 LDHB KHSRP IGBP1 HOOK3 IGF2R EIF5B PARP9 VCL RAC1 AHNAK2	2.17e-05	1367	108	15	32687490
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	ABR MYH13 TRIO SF3A1 DARS2 KHSRP TYRO3 EIF2B1 SIK2 EIF5B ZNF687 AURKB	2.68e-05	910	108	12	36736316
Pubmed	Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase.	ADCY2 ADCY5	2.86e-05	3	108	2	9268375
Pubmed	Isoform-specific membrane targeting mechanism of Rac during Fc gamma R-mediated phagocytosis: positive charge-dependent and independent targeting mechanism of Rac to the phagosome.	RAC1 RAC3	2.86e-05	3	108	2	16081809
Pubmed	Signaling and cytoskeletal requirements in erythroblast enucleation.	RAC1 RAC3	2.86e-05	3	108	2	22461493
Pubmed	Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.	PREX1 RAC1	2.86e-05	3	108	2	27150042
Pubmed	M-cadherin activates Rac1 GTPase through the Rho-GEF trio during myoblast fusion.	TRIO RAC1	2.86e-05	3	108	2	17332503
Pubmed	Novel role of Rac-Mid1 signaling in medial cerebellar development.	RAC1 RAC3	2.86e-05	3	108	2	28512198
Pubmed	Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages.	ABR RAC1	2.86e-05	3	108	2	17116687
Pubmed	Transcription factor NFYa controls cardiomyocyte metabolism and proliferation during mouse fetal heart development.	NFYA AURKB	2.86e-05	3	108	2	37972593
Pubmed	Rho-GEF trio regulates osteoclast differentiation and function by Rac1/Cdc42.	TRIO RAC1	2.86e-05	3	108	2	32898553
Pubmed	rac, a novel ras-related family of proteins that are botulinum toxin substrates.	RAC1 RAC3	2.86e-05	3	108	2	2674130
Pubmed	Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development.	RAC1 RAC3	2.86e-05	3	108	2	22123845
Pubmed	Distinct functions of Trio GEF domains in axon outgrowth of cerebellar granule neurons.	TRIO RAC1	2.86e-05	3	108	2	30850274
Pubmed	The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18.	RAC1 RAC3	2.86e-05	3	108	2	16982419
Pubmed	The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.	NUTM2E NUTM2B	2.86e-05	3	108	2	26542179
Pubmed	HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron.	APC SLC7A11	2.86e-05	3	108	2	33914705
Pubmed	Survivin-induced Aurora-B kinase activation: A mechanism by which APC mutations contribute to increased mitoses during colon cancer development.	APC AURKB	2.86e-05	3	108	2	21057000
Pubmed	Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling.	TRIO RAC1	2.86e-05	3	108	2	21422296
Pubmed	The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.	NUTM2A NUTM2B	2.86e-05	3	108	2	22456610
Pubmed	The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1).	APC XPO1	2.86e-05	3	108	2	12070164
Pubmed	Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis.	APC TYRO3	2.86e-05	3	108	2	37043564
Pubmed	New insights into the genetic basis of premature ovarian insufficiency: Novel causative variants and candidate genes revealed by genomic sequencing.	XPO1 MACF1	2.86e-05	3	108	2	33036707
Pubmed	Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA.	TRIO RAC1	2.86e-05	3	108	2	34893584
Pubmed	Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1.	PREX1 RAC1	2.86e-05	3	108	2	23478800
Pubmed	Rho family GTPases, Rac and Cdc42, control the localization of neonatal dentate granule cells during brain development.	RAC1 RAC3	2.86e-05	3	108	2	30387892
Pubmed	ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology.	RAC1 ARAP2	2.86e-05	3	108	2	23295182
Pubmed	A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.	TRIO RAC1	2.86e-05	3	108	2	24859002
Pubmed	A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1.	TRIO RAC1	2.86e-05	3	108	2	26116572
Pubmed	Pathophysiological Mechanisms in Neurodevelopmental Disorders Caused by Rac GTPases Dysregulation: What's behind Neuro-RACopathies.	RAC1 RAC3	2.86e-05	3	108	2	34943902
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	EP400 SF3A1 WDR70 CHD7 SRFBP1 JMJD1C KHSRP	3.03e-05	283	108	7	30585729
Pubmed	Human transcription factor protein interaction networks.	SP2 EP400 CHD7 SRCAP ATXN1L JMJD1C YEATS2 ZFHX4 NFYA LRP2 KDM1A VCL ZNF687 DCP1A NPAT	3.62e-05	1429	108	15	35140242
Pubmed	ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.	AUH MAP6 SF3A1 ETFA TSC22D1 VCL	4.17e-05	202	108	6	33601422
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	EP400 SF3A1 NUTM2A CHD7 SRFBP1 LDHB JMJD1C KHSRP YEATS2 NUTM2B EIF5B NPAT	4.23e-05	954	108	12	36373674
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	TRIO APC MACF1 VCL WDR62 DCP1A	5.04e-05	209	108	6	36779422
Pubmed	PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac.	RAC1 RAC3	5.71e-05	4	108	2	18319303
Pubmed	Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP.	EP400 SRCAP	5.71e-05	4	108	2	21673954
Pubmed	The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport.	IGF2R RAC1	5.71e-05	4	108	2	18596235
Interaction	PHF21A interactions	MYH13 APC CHD7 JMJD1C YEATS2 ZFHX4 KDM1A WDR62 ZNF687 DCP1A NPAT	1.95e-06	343	106	11	int:PHF21A
Interaction	GARRE1 interactions	MYH13 LDHB ZC3H7A IGF2R SIK2 RAC1 RAC3 DCP1A	2.85e-06	167	106	8	int:GARRE1
Interaction	RCOR1 interactions	APC CHD7 NR3C1 JMJD1C YEATS2 ZFHX4 KDM1A WDR62 ZNF687 DCP1A AURKB NPAT	1.12e-05	494	106	12	int:RCOR1
Interaction	ASAP1 interactions	APC TYRO3 MACF1 VCL RAC1 RAC3	1.31e-05	98	106	6	int:ASAP1
Interaction	NAA40 interactions	EP400 SF3A1 WDR70 ETFA NR3C1 SRCAP LDHB KHSRP YEATS2 IGBP1 KIAA1217 EIF5B MACF1 VCL WDR62 DCP1A AHNAK2	1.32e-05	978	106	17	int:NAA40
Interaction	RHOA interactions	ABR TRIO ETFA RALGAPB NR3C1 ARHGAP11A SLC7A11 DARS2 ITPR3 IGF2R TENM3 PTPRS LRP2 MACF1 PREX1 VPS13B RAC1 ARAP2 AURKB	1.43e-05	1199	106	19	int:RHOA
Interaction	CTNNB1 interactions	EP400 AUH APC XPO1 NR3C1 LDHB TYRO3 TSC22D1 KIF3B KIAA1217 NFYA CDH8 KDM1A VCL RAC1 RAC3 AURKB	1.98e-05	1009	106	17	int:CTNNB1
Interaction	ADCY2 interactions	NR3C1 ADCY2 ADCY5	3.89e-05	13	106	3	int:ADCY2
Interaction	PATL1 interactions	SF3A1 APC XPO1 ZC3H7A HOOK3 WDR62 DCP1A	4.20e-05	177	106	7	int:PATL1
Interaction	CLU interactions	HYOU1 XPO1 TYRO3 TENM3 PTPRS LRP2 DOCK6 KDM1A	4.60e-05	245	106	8	int:CLU
Interaction	STK3 interactions	MYH13 EMB XPO1 KHSRP ZC3H7A KIF3B AURKB	4.84e-05	181	106	7	int:STK3
Interaction	GJA1 interactions	TRIO APC FCHO2 ITPR3 IGF2R KIAA1217 LRP2 MACF1 VPS13B RAC1 ARAP2 RAC3	5.68e-05	583	106	12	int:GJA1
Interaction	PPIA interactions	EP400 TRIO ETFA FCHO2 LDHB KHSRP YEATS2 IGBP1 IGF2R MACF1 RAC1 ZNF687 RAC3 DCP1A AURKB	6.23e-05	888	106	15	int:PPIA
Interaction	PFN1 interactions	TRIO RALGAPB APC FCHO2 KIF3B KIAA1217 MACF1 VCL WDR62 RAC3 AHNAK2	7.66e-05	509	106	11	int:PFN1
Interaction	NUP50 interactions	WDR70 CHD7 XPO1 SRFBP1 LDHB KHSRP YEATS2 TSC22D1 NPAT	7.96e-05	341	106	9	int:NUP50
Interaction	DAB2 interactions	TRIO XPO1 FCHO2 ATXN1L LRP2 RAC1	9.74e-05	140	106	6	int:DAB2
Interaction	KDM1A interactions	EP400 APC CHD7 XPO1 NR3C1 JMJD1C YEATS2 ZFHX4 KIAA1217 LRP2 KDM1A WDR62 ZNF687 DCP1A NPAT	1.19e-04	941	106	15	int:KDM1A
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	TRIO EMB TYRO3 PTPRS CNTN2	3.03e-04	161	66	5	593
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY2 ADCY5	5.80e-04	10	66	2	53
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ABR TRIO PREX1	1.80e-03	66	66	3	722
GeneFamily	Rho family GTPases	RAC1 RAC3	2.39e-03	20	66	2	390
GeneFamily	PHD finger proteins\|Lysine demethylases	JMJD1C KDM1A	3.44e-03	24	66	2	485
Coexpression	GSE5542_UNTREATED_VS_IFNA_TREATED_EPITHELIAL_CELLS_24H_UP	OTOA ABR EMB NR3C1 FCHO2 ITPR3 SIK2 ARAP2	1.83e-06	200	108	8	M6524
Coexpression	GSE37301_MULTIPOTENT_PROGENITOR_VS_LYMPHOID_PRIMED_MPP_DN	EMB NR3C1 TTBK2 ST6GALNAC3 SPTY2D1 VCL ARAP2	1.03e-05	181	108	7	M8889
Coexpression	NAKAYA_MYELOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_DN	EP400 RALGAPB NR3C1 SLC7A11 TTBK2 IGF2R TRIM38 NPAT	1.53e-05	267	108	8	M41130
Coexpression	HALLMARK_MITOTIC_SPINDLE	ABR TRIO APC HOOK3 KIF3B PREX1 VCL	1.91e-05	199	108	7	M5893
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ABR ITPR3 IGF2R NUTM2B CARD6 MACF1 PREX1 ARAP2 RAC3	1.25e-10	151	108	9	0cc2f4aec3dae4603fa831f22c40f897e68b34e2
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ABR ITPR3 IGF2R NUTM2B CARD6 MACF1 PREX1 ARAP2 RAC3	1.25e-10	151	108	9	b545823113a3450c5f841f7de48bf0937593544f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	POU6F2 MAP6 PKD2L1 TYRO3 TENM3 ST6GALNAC3 ENPEP ARMH4	1.35e-08	179	108	8	7394e77e665bf16d3733df91bb12907be460ab44
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	POU6F2 MAP6 PKD2L1 TYRO3 ST6GALNAC3 ENPEP ARMH4	3.01e-07	181	108	7	5bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	POU6F2 MAP6 PKD2L1 TYRO3 ST6GALNAC3 ENPEP ARMH4	3.01e-07	181	108	7	8e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA ZAN ZFHX4 PIK3C2G LRP2 ATP1A4 CNTN2	3.36e-07	184	108	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA ZAN ZFHX4 PIK3C2G LRP2 ATP1A4 CNTN2	3.36e-07	184	108	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA ZAN ZFHX4 PIK3C2G LRP2 ATP1A4 CNTN2	3.36e-07	184	108	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_OPC\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TRIO NT5C3B CHD7 LDHB TSC22D1 C11orf96 RAC3	4.80e-07	194	108	7	920955e775617d6156c5ee8b90d2cecd01a70e12
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	POU6F2 TRIO MAP6 NRXN3 ZFHX4 C11orf96 RAC3	5.89e-07	200	108	7	c92e4fc0442404481fcac623d691dae6215b852d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 TYRO3 TENM3 ST6GALNAC3 ENPEP ARMH4	3.46e-06	168	108	6	315ca578c945aeeb77acda2727f3e6db8b43f43e
ToppCell	LA-16._Neuronal\|LA / Chamber and Cluster_Paper	NRXN3 TENM3 ST6GALNAC3 KIAA1217 PLXNB3 ARAP2	3.46e-06	168	108	6	c55bbfbde8bb954f1cb9af82007bdd1f8070fee3
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MCM10 ARHGAP11A TYRO3 WDR62 AURKB ARMH4	3.83e-06	171	108	6	0eea035fde32cc2a75a0d4227911edb5d54ed47e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 TYRO3 TENM3 ST6GALNAC3 ENPEP ARMH4	3.96e-06	172	108	6	6c17a1e586a72d1bd80c20c06370429c61dc9f85
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 PKD2L1 TYRO3 ST6GALNAC3 ENPEP ARMH4	3.96e-06	172	108	6	381ae1c3c07d0a424f43455ec571653b192a946a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 PKD2L1 TYRO3 ST6GALNAC3 ENPEP ARMH4	4.24e-06	174	108	6	dbdcdec08f1fc69fcdb5d8a6d78df8ef9c374d89
ToppCell	COVID-19-kidney-Podocyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MAP6 TYRO3 TENM3 ST6GALNAC3 ENPEP ARMH4	4.38e-06	175	108	6	a73e3a65fd5c1e09cb0c2dae20c1a7bfcae49223
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE10A JMJD1C ST6GALNAC3 KIAA1217 MACF1 DOCK6	5.15e-06	180	108	6	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH3 MAP6 KIF9 KIF3B RP1 ALDH3A1	5.15e-06	180	108	6	adf5db5bfa9a38b1227ab0beccd8d6f3eea67ac0
ToppCell	COVID-19-kidney-Podocyte\|kidney / Disease (COVID-19 only), tissue and cell type	MAP6 TYRO3 TENM3 ST6GALNAC3 ENPEP ARMH4	5.66e-06	183	108	6	fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 TYRO3 TENM3 ST6GALNAC3 ENPEP ARMH4	5.66e-06	183	108	6	612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	POU6F2 MAP6 TYRO3 TENM3 ST6GALNAC3 ARMH4	5.66e-06	183	108	6	848fc6dd129150897ee339343e83c645b6e779eb
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 TYRO3 TENM3 ST6GALNAC3 ENPEP ARMH4	5.66e-06	183	108	6	eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 TYRO3 TENM3 ST6GALNAC3 ENPEP ARMH4	5.66e-06	183	108	6	7c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MCM10 ARHGAP11A IHO1 TENM3 WDR62 AURKB	6.40e-06	187	108	6	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MCM10 ARHGAP11A IHO1 TENM3 WDR62 AURKB	6.40e-06	187	108	6	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH3 MAP6 KIF9 KIF3B RP1 ALDH3A1	6.81e-06	189	108	6	b4b93bd10b7e3cc16e54ff73beac230f519c010a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MCM10 ARHGAP11A ST6GALNAC3 PLXNB3 WDR62 AURKB	7.01e-06	190	108	6	31de1727822e9818652946dfb962daee77ffad68
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 PKD2L1 TYRO3 ST6GALNAC3 ENPEP ARMH4	7.45e-06	192	108	6	ef0aba777072429a6ab7dcfcc305673975946580
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NT5C3B CHD7 LDHB TSC22D1 C11orf96 RAC3	8.38e-06	196	108	6	fe2dd3a93fe22da93e24a400e154a68757985fc8
ToppCell	Biopsy_Other_PF-Epithelial-Proliferating_Epithelial_cells\|Biopsy_Other_PF / Sample group, Lineage and Cell type	MCM10 ARHGAP11A CNTN2 WDR62 RAC3 AURKB	9.13e-06	199	108	6	d73667e2e93026d95184e24ff0bc90afd1fb74a9
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DNAH3 ADCY2 PIK3C2G ATP2C2 RP1 ALDH3A1	9.40e-06	200	108	6	96701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE10A ADCY2 NRXN3 PIK3C2G KIAA1217 IGFL4	9.40e-06	200	108	6	b992eeddee38e6fe3564e9b1850f6b20b89bf47d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TYRO3 TENM3 ST6GALNAC3 ENPEP ARMH4	3.81e-05	155	108	5	90e629681a72baacc7981b82883866a487638dbc
ToppCell	lung-Ciliated_Epithelia\|lung / shred on tissue and cell subclass	DNAH3 KHSRP KIF9 RP1 ALDH3A1	5.43e-05	167	108	5	26cf1cfa58ee74794449a87eb19cd896e1ec8892
ToppCell	LA-16._Neuronal\|World / Chamber and Cluster_Paper	NRXN3 TENM3 KIAA1217 PLXNB3 ARAP2	5.59e-05	168	108	5	2fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 TYRO3 ST6GALNAC3 ENPEP ARMH4	5.59e-05	168	108	5	fc80e4fecfc92458eb627013a983041d8ca025a9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 TYRO3 ST6GALNAC3 ENPEP ARMH4	5.59e-05	168	108	5	e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCell	343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	MCM10 ARHGAP11A PRKG2 RAC3 AURKB	5.75e-05	169	108	5	a949f547b53126a208819bade74a1ac9b2a36ea7
ToppCell	droplet-Spleen-nan-21m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH13 LDHB IHO1 TSC22D1 PTPRS	5.75e-05	169	108	5	7962165cab84af73d20b56eb70b1ed87c94025ef
ToppCell	343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|343B / Donor, Lineage, Cell class and subclass (all cells)	MCM10 ARHGAP11A PRKG2 RAC3 AURKB	5.75e-05	169	108	5	195d5cd60d646ac6d40a3321b2f739917e7aef14
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN NRXN3 PIK3C2G LRP2 RP1	5.75e-05	169	108	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	JMJD1C MACF1 IGFL4 ENPEP ARAP2	6.08e-05	171	108	5	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ABCC4 MAP6 SLC7A11 ZFHX4 ATP2C2	6.42e-05	173	108	5	09a13407a41ff2cba82fc417b72bf9a24ce6c42e
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ABCC4 MAP6 SLC7A11 ZFHX4 ATP2C2	6.42e-05	173	108	5	bfec038a6783f166240da4861e100643c6ea80a5
ToppCell	wk_20-22-Epithelial-PNS\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ZNF177 NRXN3 TENM3 CNTN2 PLXNB3	6.42e-05	173	108	5	17b1a6b0318925d5d920f2c0a791745b9587ebef
ToppCell	droplet-Spleen-nan-3m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH13 LDHB ADCY5 TSC22D1 PTPRS	6.78e-05	175	108	5	21bc0e59a9509d38751ce6aad2325f341bc70eff
ToppCell	wk_20-22-Epithelial-PNS-Late_Schwann\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ZNF177 NRXN3 TENM3 CNTN2 PLXNB3	6.96e-05	176	108	5	81924471d8a8c5bd8eedf294c007e25b6cd3e417
ToppCell	T_cells-Tph_and_Tfh\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	MAP6 NR3C1 ST6GALNAC3 KIAA1217 RAC3	6.96e-05	176	108	5	56c055488e34605d32562571a2fee621b47c9441
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l2\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	POU6F2 KIF3B CARF SIK2 DCP1A	6.96e-05	176	108	5	1510cdfcfb46ce1196a1220c07fb5f3986c81b78
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	HYOU1 CHD7 ARHGAP11A LPIN1 SIK2	6.96e-05	176	108	5	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	HYOU1 CHD7 ARHGAP11A LPIN1 SIK2	7.15e-05	177	108	5	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	droplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY5 C11orf96 ENPEP VCL ARAP2	7.74e-05	180	108	5	78fdcfb3fdbf36469cae78407cda5bd0996930d8
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EMB TENM3 PIK3C2G KIAA1217 ATP2C2	7.74e-05	180	108	5	e8841ef1239f9ee73ac4f4e11faca0742694f368
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	IGF2R PTPRS MACF1 PRKG2 ENPEP	8.16e-05	182	108	5	ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCell	COVID-19_Mild-gd_T\|COVID-19_Mild / Disease condition and Cell class	IGF2R MACF1 SPTY2D1 VCL ARAP2	8.37e-05	183	108	5	f593a89b0aa8fffdfa403769916facfd30358521
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 TYRO3 ST6GALNAC3 ENPEP ARMH4	8.37e-05	183	108	5	3c516fe5083f02bad1f464ed284010b4131a833c
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	TRIO NR3C1 JMJD1C PARP9 TRIM38	8.37e-05	183	108	5	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 TYRO3 ST6GALNAC3 ENPEP ARMH4	8.37e-05	183	108	5	9c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_OPC-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CHD7 LDHB TSC22D1 C11orf96 RAC3	8.37e-05	183	108	5	8c8ce5a0d5535bef58ac10b7eb726f9c50af2ed8
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APC NR3C1 FCHO2 JMJD1C MACF1	8.59e-05	184	108	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 TYRO3 ST6GALNAC3 ENPEP ARMH4	8.59e-05	184	108	5	7294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 TYRO3 TENM3 ST6GALNAC3 ARMH4	8.81e-05	185	108	5	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 TYRO3 TENM3 ST6GALNAC3 ARMH4	8.81e-05	185	108	5	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR3C1 FCHO2 JMJD1C MACF1 ENPEP	8.81e-05	185	108	5	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 TYRO3 TENM3 ST6GALNAC3 ARMH4	8.81e-05	185	108	5	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	Control-Endothelial_cells-Endothelial_cells_(other)\|Control / group, cell type (main and fine annotations)	PDE10A ST6GALNAC3 KIAA1217 DOCK6 PREX1	9.04e-05	186	108	5	c6075fe84226b370c5139066793844ad33ae2db1
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	APC SRFBP1 SPTY2D1 VPS13B NPAT	9.04e-05	186	108	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHD7 ZFHX4 LRP2 PREX1 PLXNB3	9.27e-05	187	108	5	97e520705491c8f52a32025311a9fa7b9176979a
ToppCell	Control-Endothelial_cells-Endothelial_cells_(general)\|Control / group, cell type (main and fine annotations)	PDE10A NRXN3 ST6GALNAC3 KIAA1217 PREX1	9.27e-05	187	108	5	fb5bcbc8effdbf0e57fcb71aca990a4aa0d65ce8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MCM10 ARHGAP11A PIK3C2G WDR62 AURKB	9.27e-05	187	108	5	057569c9437219ecc396aa6e673b1178a2273837
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MCM10 ARHGAP11A PREX1 WDR62 AURKB	9.27e-05	187	108	5	73931a5ea73799095daff100b5f18853c57c74dc
ToppCell	E16.5-samps-Mesenchymal\|E16.5-samps / Age Group, Lineage, Cell class and subclass	NR3C1 IGF2R PTPRS MACF1 ENPEP	9.50e-05	188	108	5	3f0f662be684e3a4c6652e636cc135a39a1d2790
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D122\|Adult / Lineage, Cell type, age group and donor	NRXN3 ST6GALNAC3 KIAA1217 DOCK6 CDH8	9.50e-05	188	108	5	02a62888e9db29d20133eeca1686d302545a39c9
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 TYRO3 ST6GALNAC3 ENPEP ARMH4	9.50e-05	188	108	5	9db778c1d9e622a68337212296e3a1ed8f771fa5
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHD7 SLC7A11 ZFHX4 PREX1 PLXNB3	9.50e-05	188	108	5	505b6b4277d7dea87aee27191d0acca67928b8e6
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D175\|Adult / Lineage, Cell type, age group and donor	ABCC4 SLC7A11 NRXN3 C11orf96 ATP2C2	9.50e-05	188	108	5	ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCHO2 JMJD1C C11orf96 ALDH3A1 SPTY2D1	9.50e-05	188	108	5	5e13725136114e42d3b59647cf25e0f3c53abb54
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP6 TYRO3 ST6GALNAC3 ENPEP ARMH4	9.50e-05	188	108	5	047c4e0b03fc8334e38c48977e41d26dbe229d47
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NRXN3 ATP2C2 LRP2 RP1 ARAP2	9.74e-05	189	108	5	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHD7 ZFHX4 LRP2 PREX1 PLXNB3	9.74e-05	189	108	5	42ab4cc5fbf8580841f31889446fe4499df1a464
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC4 TENM3 LRP2 TRIM38 ENPEP	9.74e-05	189	108	5	28b502611829e4a24caff2562545c7db97686099
ToppCell	E18.5-samps-Mesenchymal\|E18.5-samps / Age Group, Lineage, Cell class and subclass	ADCY2 TSC22D1 IGF2R PTPRS MACF1	9.74e-05	189	108	5	0c18d3de4720759cf802eefb4d0ddde2a9246a1a
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	EMB NRXN3 PIK3C2G ATP2C2 LRP2	9.99e-05	190	108	5	625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHD7 SLC7A11 ZFHX4 PREX1 PLXNB3	9.99e-05	190	108	5	2de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C11orf96 PARP9 ENPEP VCL ARAP2	9.99e-05	190	108	5	1ab3f19f1ce9f58e5125135704d94655a2e330a0
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHD7 ZFHX4 LRP2 PREX1 PLXNB3	9.99e-05	190	108	5	ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal\|E16.5-samps / Age Group, Lineage, Cell class and subclass	IGF2R PTPRS MACF1 PRKG2 ENPEP	1.02e-04	191	108	5	3379d145d34f89150f7b06d1340022cfc6b4a6ce
ToppCell	Control-Epithelial-Ciliated_cells\|Control / Condition, Lineage and Cell class	DNAH3 MAP6 ATP2C2 RP1 AHNAK2	1.02e-04	191	108	5	ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCell	facs-Heart-LA-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY5 C11orf96 ENPEP VCL ARAP2	1.02e-04	191	108	5	9c5d88f0d3c834c2419ec3da74652175153ba9df
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	IGF2R PTPRS MACF1 PRKG2 ENPEP	1.02e-04	191	108	5	e7c605b56934d1383237c1f946dbccef25d91368
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHD7 ZFHX4 LRP2 CNTN2 PLXNB3	1.02e-04	191	108	5	2110a1dd10730ad7ee7a265fb1716ab3ddafcf4a
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHD7 ZFHX4 LRP2 PREX1 PLXNB3	1.02e-04	191	108	5	2b056cbe2e82e056e1f798974999378460eb1d16
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHD7 SLC7A11 ZFHX4 PREX1 PLXNB3	1.02e-04	191	108	5	f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCell	Control-Epithelial\|Control / Condition, Lineage and Cell class	DNAH3 MAP6 ATP2C2 RP1 AHNAK2	1.02e-04	191	108	5	6228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCell	facs-Heart-LA-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY5 C11orf96 ENPEP VCL ARAP2	1.02e-04	191	108	5	a7494191a92984e5f53610bbbedd6714e9169e1c
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NR3C1 LPIN1 TSC22D1 NRXN3 C11orf96	1.05e-04	192	108	5	93903576dddd8227328e4ced75aa7625eedb9baf
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	IHO1 EIF5B WDR62 AHNAK2 AURKB	1.05e-04	192	108	5	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	EMB ITPR3 NRXN3 ATP2C2 LRP2	1.05e-04	192	108	5	d3634574b2e8d2ded6446969361b70761b331aea
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCC4 ITPR3 PIK3C2G KIAA1217 ATP2C2	1.05e-04	192	108	5	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
Drug	Apomorphine hydrochloride hemihydrate [41372-20-7]; Up 200; 6.4uM; MCF7; HT_HG-U133A	LDHB KHSRP TTBK2 ZFHX4 PTPRS CARF CDH8 AHNAK2	4.11e-06	196	107	8	1505_UP
Drug	Pirenperone [ 75444-65-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A	TRIO APC PTPRS DOCK6 CDH8 WDR62 RAC3 NPAT	4.27e-06	197	107	8	5274_DN
Disease	autosomal dominant intellectual developmental disorder 48 (implicated_via_orthology)	RAC1 RAC3	3.97e-05	3	108	2	DOID:0080235 (implicated_via_orthology)
Disease	serum metabolite measurement	ABCC4 POU6F2 TRIO PKD2L1 PDE10A SLC7A11 RPIA IGF2R TENM3 ST6GALNAC3 DOCK6 ENPEP ARMH4	4.27e-05	945	108	13	EFO_0005653
Disease	Liver carcinoma	ETFA APC MCM10 ARHGAP11A IGBP1 IGF2R WDR62 RAC1 AURKB	1.06e-04	507	108	9	C2239176
Disease	Endometrial Stromal Sarcoma	NUTM2A NUTM2B	1.32e-04	5	108	2	C0206630
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	1.97e-04	6	108	2	C0334488
Disease	pack-years measurement, systolic blood pressure	NRXN3 LRP2 PRKG2	2.63e-04	34	108	3	EFO_0006335, EFO_0006526
Disease	postherpetic neuralgia	ABCC4 NRXN3	3.66e-04	8	108	2	MONDO_0041052
Disease	Prostatic Neoplasms	ABCC4 ABR APC CHD7 XPO1 NR3C1 LDHB IGF2R LRP2	4.44e-04	616	108	9	C0033578
Disease	Malignant neoplasm of prostate	ABCC4 ABR APC CHD7 XPO1 NR3C1 LDHB IGF2R LRP2	4.44e-04	616	108	9	C0376358
Disease	HEPATOCELLULAR CARCINOMA	APC IGF2R	4.70e-04	9	108	2	114550
Disease	Hepatocellular carcinoma	APC IGF2R	4.70e-04	9	108	2	cv:C2239176
Disease	triacylglycerol 54:1 measurement	IGF2R ZFHX4	5.86e-04	10	108	2	EFO_0010419
Disease	end stage renal disease (biomarker_via_orthology)	NR3C1 LPIN1 LRP2	6.88e-04	47	108	3	DOID:783 (biomarker_via_orthology)
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ATXN1L ITPR3	8.55e-04	12	108	2	DOID:1441 (implicated_via_orthology)
Disease	diglyceride measurement	ABR PKD2L1 PDE10A	8.74e-04	51	108	3	EFO_0010223
Disease	neuroticism measurement, cognitive function measurement	POU6F2 EMB APC ADCY2 JMJD1C TENM3 KIAA1217 AURKB	1.15e-03	566	108	8	EFO_0007660, EFO_0008354
Disease	nephroblastoma (is_implicated_in)	POU6F2 IGF2R	1.17e-03	14	108	2	DOID:2154 (is_implicated_in)
Disease	obesity (implicated_via_orthology)	NR3C1 ITPR3 LPIN1 ZFHX4 PLXNB3	1.19e-03	215	108	5	DOID:9970 (implicated_via_orthology)
Disease	Intellectual Disability	TRIO APC LRP2 MACF1 WDR62 RAC1 RAC3	1.31e-03	447	108	7	C3714756
Disease	amyotrophic lateral sclerosis, age at onset	NRXN3 ARAP2	1.35e-03	15	108	2	EFO_0004847, MONDO_0004976
Disease	coronary artery disease	MAP6 EMB PKD2L1 SRFBP1 IGF2R KIAA1217 CARF SIK2 RP1 DOCK6 PREX1 RAC1	1.42e-03	1194	108	12	EFO_0001645
Disease	phospholipids:total lipids ratio	ETFA JMJD1C IGF2R MACF1 DOCK6	1.51e-03	227	108	5	EFO_0020946
Disease	Neoplastic Cell Transformation	APC TSC22D1 IGBP1 RAC1	1.73e-03	139	108	4	C0007621
Disease	cyclic adenosine monophosphate measurement	ABCC4 ARAP2	1.74e-03	17	108	2	EFO_0010473
Disease	pulmonary surfactant-associated protein d measurement	NUTM2E ATP2C2	1.95e-03	18	108	2	EFO_0020693
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	ETFA JMJD1C IGF2R MACF1 DOCK6	2.04e-03	243	108	5	EFO_0004612, EFO_0020944
Disease	congenital heart disease (implicated_via_orthology)	CHD7 ADCY2 LRP2	2.10e-03	69	108	3	DOID:1682 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	CHD7 ITPR3 NRXN3 PREX1	2.40e-03	152	108	4	DOID:0060041 (implicated_via_orthology)
Disease	selenium measurement, response to dietary selenium supplementation	TRIO ZC3H7A	2.42e-03	20	108	2	EFO_0006331, EFO_0600021
Disease	monounsaturated fatty acids; 16:1, 18:1 measurement	PKD2L1 JMJD1C IGF2R	2.97e-03	78	108	3	EFO_0022187
Disease	hemoglobin A1 measurement	ETFA PKD2L1 LDHB JMJD1C ADCY5 MACF1 RAC1	3.06e-03	520	108	7	EFO_0007629
Disease	eosinophil count	DNAH3 AUH EMB ZNF177 SF3A1 CHD7 XPO1 NR3C1 SLC7A11 ITPR3 IHO1 KIF3B SIK2	3.09e-03	1488	108	13	EFO_0004842

Protein segments in the cluster

Peptide	Gene	Start	Entry
MGKGQIQLDPQTVET	ABR	591	Q12979
MGPGIKAGLQVSNVV	ARSK	341	Q6UWY0
MNVAGISVAIGQPQK	EP400	2936	Q96L91
TMADGVPGVQNILKI	NT5C3B	236	Q969T7
TIQPMVGAIAAGNSV	ALDH3A1	121	P30838
SINKETQPGQAGLMQ	ARMH4	91	Q86TY3
IQVVVPVDGGVTNMQ	FCHO2	706	Q0JRZ9
MAQKNVGVRPGDAIQ	SPATA5	116	Q8NB90
GITIIPMNVANVKQV	ARAP2	626	Q8WZ64
NNFQMKIGLNIGPVV	ADCY5	1171	O95622
QIQTQPLGKGAMVAS	DCP1A	406	Q9NPI6
KGGGQANVPNLLNTM	CHD7	1231	Q9P2D1
VIRKNAVMGQPTEGA	ATP2C2	446	O75185
SANVMVDGKPVNLGL	RAC3	41	P60763
SANVMVDGKPVNLGL	RAC1	41	P63000
GKDQGLVQMVPDAVT	PIK3C2G	961	O75747
GPVAKSILQQAGVEM	PARP9	346	Q8IXQ6
VPNNGQNVLDIMVTK	ITPR3	486	Q14573
VGMIPVSVVGQNGNN	NPAT	946	Q14207
PAQQQGILSKMVQAE	OTOA	501	Q7RTW8
TPTNILGGNVEMKIQ	MAP10	631	Q9P2G4
QGSMVSEPVKNQGLV	MAP6	661	Q96JE9
QGPVAMRVAKLAINQ	AUH	281	Q13825
LGGTVMPNKTVRAVQ	IHO1	516	Q8IYA8
KAMVVANGNLVPTGT	ATXN1L	411	P0C7T5
TLTPVMPVNAGGKVQ	JMJD1C	1231	Q15652
TQTGMAQVIIPQGQL	CARF	121	Q8N187
VENGGIINKIGTNQM	EIF2B1	201	Q14232
GLPQFVVQMGNVQLA	PLXNB3	1221	Q9ULL4
VVQMGNVQLALGPVQ	PLXNB3	1226	Q9ULL4
VPAFQGALTMKQVNP	IGBP1	81	P78318
KGVGVFNTVINPMLN	OR3A2	281	P47893
GSVIGVVQMVNKISG	PDE10A	376	Q9Y233
MAAENNPNIKINGSV	NRXN3	1246	Q9Y4C0
VDPLQMKLQQVNGLG	MACF1	1411	O94854
VGGALLDQNKPQTEM	LPIN1	326	Q14693
KVMGNDLGFPQQGQI	NR3C1	96	P04150
KSNDAMVPIAGIQNG	LRP2	1766	P98164
EQGTVVGILNANPMK	MCM10	346	Q7L590
QMGYPVLNVNGVKNI	ENPEP	541	Q07075
MTIVENPQGVFIKGL	KIF9	166	Q9HAQ2
TNGVVMAQVLQKIDP	HOOK3	36	Q86VS8
KEQPQALNFGGIGMV	MMEL1	596	Q495T6
KLQDVVHMQGGSPLQ	PRKG2	81	Q13237
IQVKTQQGVPGQPMN	PTPRS	516	Q13332
KQSMLNVTVNGGGNV	ABCC4	741	O15439
IQRLQGPKAGQMENT	ADCY2	261	Q08462
KEAGMQPQLQIRGVG	HYOU1	251	Q9Y4L1
GLGGNPMAVVSKQVN	KDM1A	336	O60341
VQMKTQGGASNPALQ	CARD6	916	Q9BX69
QMVLQGSVGPTVNQG	DOCK6	1931	Q96HP0
QGQGPIAAKMINNAI	DNAH3	3556	Q8TD57
GSQNQTVVRFKVPGM	IGFL4	81	Q6B9Z1
VGGNLVIMNPTKAQD	CNTN2	91	Q02246
NNKITVVGVGQVGMA	LDHB	21	P07195
VPVGVQMNKYVINGT	EMB	201	Q6PCB8
QAKNGVMVLAGVTDP	nan	46	Q6ZN92
ENGKPGQVIQTVSAM	CDH8	506	P55286
QGQPLMVQVSGGQLI	NFYA	56	P23511
MQVPVSGTQGLQQIQ	NFYA	91	P23511
TQNGVVQMPGSLAGV	RP1	1101	P56715
ELQGMGKPGRVNQTT	OR1N2	11	Q8NGR9
QMRTEVGPVKAAQAQ	NUTM2A	206	Q8IVF1
QMRTEVGPVKAAQAQ	NUTM2B	206	A6NNL0
QMRTEVGPVKAAQAQ	NUTM2E	206	B1AL46
MAVNKAGPVVTDNGN	RPIA	241	P49247
QNGTVQEIMIPAGKA	KHSRP	231	Q92945
AVKPQEVQMVNGTIT	IGF2R	2126	P11717
EVQMVNGTITNPING	IGF2R	2131	P11717
VKPVVNNNMGISSGI	ARHGAP11A	971	Q6P4F7
QSPQQFKQLLMVGGL	DARS2	241	Q6PI48
ENVQRGTGMKQEPQS	TRIM38	366	O00635
VLKVSPFNNGQLVMG	SLC26A8	161	Q96RN1
MAAENNPNIKINGSV	NRXN3	241	Q9HDB5
VTNAQGQIIGTIPLM	POU6F2	336	P78424
FVPNDMQVGQTGKIV	ETFA	256	P13804
GVTVEAGQVKQGTPM	EIF5B	1111	O60841
ILKVNGSNVMNDGAP	PREX1	751	Q8TCU6
NGPQMEFQKVTTGAV	KIAA1217	1196	Q5T5P2
AIVSNSGQMVGQKVG	ST6GALNAC3	81	Q8NDV1
SEVTNQLVVMPGAGK	SIK2	486	Q9H0K1
SGEMGAPTVVVQQQQ	TSC22D1	486	Q15714
NQVPPTMVNNTGVVK	SRCAP	1296	Q6ZRS2
NKGPVSIKVQVPNMQ	SF3A1	701	Q15459
ILMIASKGQGVNNVP	SPTY2D1	6	Q68D10
VVQAGQVDMKLPEGQ	AHNAK2	1881	Q8IVF2
QAKQNVGNGSVPMRT	APC	2701	P25054
NMVPQQALVIRGGEK	ATP1A4	171	Q13733
MGNKQPQKVTVPTGT	C11orf96	1	Q7Z7L8
NVQPTAAPGQKVMEN	AURKB	46	Q96GD4
IVPGVMQLIKGQTQN	SLC7A11	206	Q9UPY5
AIQANGEMVTKQPLI	XPO1	731	O14980
AQNIGLTGMKLENPA	ZFHX4	826	Q86UP3
NEMLTKEQGNVIGIP	ZNF33B	111	Q06732
IAMQNIPGGKTSNGI	ZNF177	96	Q13360
MAQPGTLNLNNEVVK	SRFBP1	1	Q8NEF9
GGNAKTVMVANVGPA	KIF3B	306	O15066
MQTININGVQVQGVP	SP2	436	Q02086
PKLNQIMVGTGNGLA	WDR70	481	Q9NW82
PHVEGQIGQVAEMQK	TTBK2	861	Q6IQ55
RGQGSSPVAMQKAQQ	VCL	341	P18206
SPVAMQKAQQVSQGL	VCL	346	P18206
PGKMQGTLEDQIIQA	MYH13	211	Q9UKX3
VAKRNMTLPGENGQN	TENM3	1731	Q9P273
IQGATGKFNMVIPLV	RALGAPB	1406	Q86X10
MNAVGSPEGQELQKL	PKD2L1	1	Q9P0L9
VKAGVRVMQVSPDGQ	WDR62	491	O43379
EANVPGAQVLGNQIM	ZC3H7A	686	Q8IWR0
IAGIVDQPMQNFQKT	VPS13B	3766	Q7Z7G8
GGQKVNGASVVMVQP	ZNF687	461	Q8N1G0
MGAPVKLTVSQGQPV	TYRO3	46	Q06418
PGIVNKELIIFGNMQ	TRIO	1331	O75962
NTSGGVQTILMPVNK	YEATS2	1061	Q9ULM3
GHQQPMQLIFKGIQG	ZAN	501	Q9Y493
AAMQAGLLKVVPQAV	HECTD3	716	Q5T447