Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprofilin binding

PCLO HTT ENAH

1.52e-0613363GO:0005522
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

HOXA10 CDX2 ZNF219 ATF5 KDM6B RFX1 ZNF865 ZNF341 MEF2A FOXK1

1.84e-0414593610GO:0000977
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

HOXA10 CDX2 ZNF219 KDM6B RFX1 ZNF865 ZNF341 MEF2A FOXK1

2.79e-041244369GO:0000978
GeneOntologyMolecularFunctionchromatin binding

ATF5 KDM6B EP400 ZC3H4 MEF2A BRD4 KAT6A

3.02e-04739367GO:0003682
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

HOXA10 CDX2 ZNF219 KDM6B RFX1 ZNF865 ZNF341 MEF2A FOXK1

3.27e-041271369GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

HOXA10 CDX2 ZNF219 ATF5 RFX1 ZNF341 MEF2A FOXG1 FOXK1

7.08e-041412369GO:0000981
GeneOntologyCellularComponentchromatin

HOXA10 SETD1A CDX2 ATF5 EP400 RFX1 CPSF6 MEF2A FOXG1 FOXK1 BRD4 KAT6A

3.84e-0614803612GO:0000785
GeneOntologyCellularComponentmethyltransferase complex

SETD1A BOD1L1 KDM6B VIRMA

3.49e-05108364GO:0034708
GeneOntologyCellularComponenttransferase complex

SETD1A FBXO11 BOD1L1 KDM6B EP400 VIRMA BRD4 KAT6A

1.88e-04963368GO:1990234
GeneOntologyCellularComponenthistone methyltransferase complex

SETD1A BOD1L1 KDM6B

2.91e-0475363GO:0035097
GeneOntologyCellularComponentSet1C/COMPASS complex

SETD1A BOD1L1

3.41e-0416362GO:0048188
GeneOntologyCellularComponentnuclear speck

SETD1A EP400 VIRMA CPSF6 KAT6A

8.10e-04431365GO:0016607
GeneOntologyCellularComponentnuclear chromosome

CDX2 EP400 CPSF6 BRD4

9.24e-04254364GO:0000228
Domain-

RFX1 FOXG1 FOXK1 KAT6A

7.94e-042183641.10.10.10
DomainWHTH_DNA-bd_dom

RFX1 FOXG1 FOXK1 KAT6A

1.17e-03242364IPR011991
DomainAT_hook

PRR12 BOD1L1

1.23e-0327362SM00384
DomainAT_hook_DNA-bd_motif

PRR12 BOD1L1

1.23e-0327362IPR017956
DomainTF_fork_head_CS_2

FOXG1 FOXK1

3.54e-0346362IPR030456
DomainTF_fork_head_CS_1

FOXG1 FOXK1

3.70e-0347362IPR018122
DomainFORK_HEAD_3

FOXG1 FOXK1

4.01e-0349362PS50039
DomainFH

FOXG1 FOXK1

4.01e-0349362SM00339
DomainFORK_HEAD_1

FOXG1 FOXK1

4.01e-0349362PS00657
DomainFORK_HEAD_2

FOXG1 FOXK1

4.01e-0349362PS00658
DomainForkhead

FOXG1 FOXK1

4.01e-0349362PF00250
DomainFork_head_dom

FOXG1 FOXK1

4.01e-0349362IPR001766
DomainRRM

SETD1A CPSF6 RBM20

8.33e-03217363SM00360
DomainRRM_dom

SETD1A CPSF6 RBM20

9.42e-03227363IPR000504
DomainRRM

SETD1A CPSF6 RBM20

9.76e-03230363PS50102
Domain-

SETD1A CPSF6 RBM20

1.14e-022443633.30.70.330
DomainHomeobox_metazoa

HOXA10 CDX2

1.30e-0290362IPR020479
DomainNucleotide-bd_a/b_plait

SETD1A CPSF6 RBM20

1.33e-02258363IPR012677
Pubmed

Human transcription factor protein interaction networks.

ZNF462 HOXA10 PRR12 SETD1A FBN2 HNRNPUL1 EP400 RFX1 SOBP MEF2A RBM20 PEG10 FOXK1

8.61e-101429361335140242
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

PRR12 EP400 ZC3H4 CPSF6 MEF2A FOXK1 BRD4

1.03e-0826836733640491
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

PRR12 SETD1A BOD1L1 HNRNPUL1 EP400 RFX1 ZC3H4 CPSF6

1.71e-0845336829656893
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

SETD1A EP400 RFX1 ZC3H4 CPSF6 PEG10 FOXK1

5.36e-0834136732971831
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PRR12 SETD1A KDM6B EP400 ZNF865 ZNF341 FOXK1 BRD4 HTT KAT6A

1.21e-071105361035748872
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

ZNF462 SETD1A BOD1L1 EP400 ZC3H4 CPSF6 BRD4

4.62e-0746936727634302
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

ZNF462 HOXA10 ZNF219 ATF5 MEF2A FOXG1 FOXK1 BRD4

5.24e-0770936822988430
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

HNRNPUL1 VIRMA CPSF6 BRD4 ENAH

5.38e-0715436516055720
Pubmed

BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A.

SETD1A BOD1L1

1.04e-06236238989615
Pubmed

Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression via the CREB-Regulated Transcription Coactivator 1-cAMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway.

SIK2 CRTC1

1.04e-06236230503507
Pubmed

Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease.

CRTC1 HTT

1.04e-06236222589249
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

SETD1A BOD1L1 EP400 RFX1 BRD4 HTT ENAH

1.32e-0654936738280479
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF462 CDX2 ZNF219 HNRNPUL1 RFX1 MEF2A FOXK1 BRD4

1.39e-0680836820412781
Pubmed

Interaction network of human early embryonic transcription factors.

ZNF462 PRR12 SETD1A EP400 SOBP FOXK1

1.53e-0635136638297188
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

HOXA10 FBXO11 CDX2 EP400 RFX1 MEF2A FOXG1 FOXK1

2.16e-0685736825609649
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ZNF462 HOXA10 BOD1L1 RFX1 FOXK1 BRD4 KAT6A

2.59e-0660836736089195
Pubmed

Study of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development.

CDX2 RFX1

3.12e-06336221935353
Pubmed

Functional interactions between the Forkhead transcription factor FOXK1 and the MADS-box protein SRF.

FOXG1 FOXK1

3.12e-06336217670796
Pubmed

HCN channels expressed in the inner ear are necessary for normal balance function.

HCN2 FOXG1

3.12e-06336222090507
Pubmed

SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB.

SIK2 CRTC1

3.12e-06336221220102
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

PRR12 EP400 RBM20 FOXK1 BRD4 PCLO

3.15e-0639836635016035
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ZNF462 PRR12 CRTC1 RFX1 RBM20 BRD4

4.17e-0641836634709266
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

SETD1A BOD1L1 HNRNPUL1 ZC3H4 CPSF6

5.91e-0625136531076518
Pubmed

Downregulation of SIK2 expression promotes the melanogenic program in mice.

SIK2 CRTC1

6.24e-06436220819186
Pubmed

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway.

CRTC1 HTT

6.24e-06436222179316
Pubmed

Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade.

SIK2 CRTC1

6.24e-06436216817901
Pubmed

Genetic analysis of jumbled spine and ribs (Jsr) mutation affecting the vertebral development in mice.

CDX2 FOXK1

6.24e-06436212392169
Pubmed

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.

BOD1L1 BRD4

1.04e-05536226626481
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

BOD1L1 EP400 ZC3H4 CPSF6 BRD4

1.06e-0528336530585729
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

BOD1L1 EP400 ZC3H4 CPSF6 BRD4 ENAH

1.24e-0550636630890647
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

PRR12 HNRNPUL1 EP400 RFX1 CPSF6 MEF2A FOXK1 BRD4

1.37e-05110336834189442
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

HOXA10 ZNF219 FBN2 EP400 ZC3H4 FOXK1 BRD4 KAT6A

1.49e-05111636831753913
Pubmed

Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice.

CDX2 FOXK1

1.56e-05636210383162
Pubmed

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.

HNRNPUL1 ZC3H4 CPSF6 BRD4

1.67e-0514836432538781
Pubmed

New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.

HOXA10 CDX2 KDM6B

1.93e-055036328188179
Pubmed

Jumbled spine and ribs (Jsr): a new mutation on mouse chromosome 5.

CDX2 FOXK1

2.18e-05736210051313
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

SIK2 CRTC1 BOD1L1 HNRNPUL1 VIRMA FOXK1 BRD4

2.48e-0586136736931259
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

ZNF462 FBXO11 CDX2 FBN2 RFX1 VIRMA FOXG1 BRD4

2.56e-05120336829180619
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

ZNF462 ZNF219 EP400 PEG10

2.68e-0516736420362541
Pubmed

High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population.

ZNF462 HOXA10 ZNF219

2.72e-055636319591821
Pubmed

New nomenclature for chromatin-modifying enzymes.

SETD1A KDM6B KAT6A

2.87e-055736318022353
Pubmed

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.

SIK2 CRTC1

2.91e-05836215454081
Pubmed

Co-opting the unfolded protein response to elicit olfactory receptor feedback.

ATF5 FOXG1

2.91e-05836224120133
Pubmed

Functional proteomics mapping of a human signaling pathway.

FBN2 HNRNPUL1 RFX1 ZNF341 PEG10 BRD4

2.96e-0559136615231748
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

HOXA10 PRR12 FBXO11 ZNF219 HNRNPUL1 EP400 FOXK1 BRD4

4.29e-05129436830804502
Pubmed

ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer.

FOXK1 BRD4

4.66e-051036232669118
Pubmed

ZC3H4-a novel Cys-Cys-Cys-His-type zinc finger protein-is essential for early embryogenesis in mice†.

CDX2 ZC3H4

4.66e-051036233246328
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

BOD1L1 HNRNPUL1 EP400 RFX1 ZC3H4 CPSF6 BRD4

4.76e-0595436736373674
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ZNF462 ZNF219 HCN2 VIRMA ZC3H4 FOXG1 ENAH

5.05e-0596336728671696
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

FBXO11 EP400 ZNF865 PEG10 PCLO

5.26e-0539636526687479
Pubmed

EED and KDM6B coordinate the first mammalian cell lineage commitment to ensure embryo implantation.

CDX2 KDM6B

5.70e-051136223671187
Pubmed

Genomic analysis of mouse retinal development.

ZNF219 RFX1 ZC3H4 CPSF6 MEF2A FOXK1 BRD4

6.65e-05100636715226823
Pubmed

Excessive versus physiologically relevant levels of retinoic acid in embryonic stem cell differentiation.

HOXA10 KAT6A

6.83e-051236225099890
Pubmed

BET proteins are essential for the specification and maintenance of the epiblast lineage in mouse preimplantation embryos.

CDX2 BRD4

8.07e-051336235264162
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

PRR12 EP400 FOXK1

8.84e-058336328794006
Pubmed

The lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors.

FOXG1 KAT6A

9.41e-051436225757017
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

ZNF462 FBXO11 HNRNPUL1 EP400 ZC3H4 CPSF6 BRD4

1.05e-04108236738697112
Pubmed

Heterochromatin-mediated gene silencing facilitates the diversification of olfactory neurons.

ATF5 FOXG1

1.24e-041636225437545
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

HNRNPUL1 EP400 RFX1 VIRMA ZC3H4 BRD4

1.31e-0477436615302935
Pubmed

Differential requirements for Tousled-like kinases 1 and 2 in mammalian development.

CDX2 PEG10

1.40e-041736228708136
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

ZNF462 SETD1A FBXO11 BOD1L1 FOXK1

1.50e-0449536527705803
Pubmed

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.

ADAMTS19 FBN2

1.58e-041836235503090
Pubmed

Switching axial progenitors from producing trunk to tail tissues in vertebrate embryos.

HOXA10 CDX2

1.76e-041936223763947
Pubmed

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

SETD1A FOXK1

1.96e-042036229785026
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

ZNF462 BOD1L1 EP400 RFX1

2.03e-0428236423667531
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SETD1A CRTC1 KDM6B EP400 ZC3H4

2.04e-0452936514621295
Pubmed

The DNA sequence and biology of human chromosome 19.

CRTC1 HCN2 ZNF865 BRD4

2.09e-0428436415057824
Pubmed

The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.

KDM6B FOXG1

2.16e-042136227600842
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

HOXA10 CDX2 RFX1 FOXG1 FOXK1

2.32e-0454436528473536
Pubmed

Embryo model completes gastrulation to neurulation and organogenesis.

CDX2 FOXG1

2.38e-042236236007540
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

SETD1A BOD1L1

2.38e-042236226886794
Pubmed

Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis.

HNRNPUL1 VIRMA CPSF6

2.44e-0411736334662580
Pubmed

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

SETD1A BOD1L1 ZC3H4

2.57e-0411936323508102
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

HOXA10 CDX2 ZNF219 ATF5 HNRNPUL1 FOXG1

2.58e-0487736620211142
Pubmed

A census of human transcription factors: function, expression and evolution.

CDX2 ATF5 RFX1 MEF2A FOXG1 FOXK1

3.11e-0490836619274049
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

HOXA10 EP400 RFX1 ZNF865 FOXK1

3.19e-0458336529844126
Pubmed

A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis.

ATF5 FOXG1

3.33e-042636226651292
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

SETD1A HNRNPUL1 VIRMA ZC3H4 CPSF6 FOXG1

3.37e-0492236627609421
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

BOD1L1 HNRNPUL1 EP400 ZC3H4 CPSF6 ENAH

3.61e-0493436633916271
Pubmed

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

SETD1A EP400 BRD4

3.64e-0413436325452129
Pubmed

Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.

ZNF462 HTT

3.87e-042836225752541
Pubmed

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron.

KDM6B FOXG1

4.16e-042936217928865
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

ZNF462 ZNF219 EP400

4.67e-0414636323892456
Pubmed

Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis.

HOXA10 EP400

5.07e-043236217535249
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

PRR12 HNRNPUL1 VIRMA ZC3H4

5.17e-0436136430344098
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

PRR12 SOBP CPSF6

5.26e-0415236338360978
Pubmed

Forkhead box a2 (FOXA2) is essential for uterine function and fertility.

HOXA10 CDX2

5.39e-043336228049832
Pubmed

The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.

CDX2 BRD4

5.39e-043336219336002
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

KDM6B BRD4

5.39e-043336226864203
Pubmed

Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets.

KDM6B PEG10

5.72e-043436232553152
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

KDM6B EP400 KAT6A

5.78e-0415736330186101
Pubmed

Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase.

EP400 ENAH

6.07e-043536221779533
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

SIK2 CRTC1 CPSF6 MEF2A FOXK1 ENAH

6.31e-04103836626673895
Pubmed

Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.

CPSF6 RBM20 FOXG1

6.67e-0416536316107646
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

SETD1A HNRNPUL1 EP400 BRD4

7.17e-0439436427248496
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ZNF462 BOD1L1 SOBP MEF2A HTT KAT6A ENAH

7.28e-04148936728611215
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

PRR12 FBXO11 CRTC1 EP400 VIRMA CPSF6 FOXK1

7.52e-04149736731527615
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

BOD1L1 ZC3H4 CPSF6 BRD4

7.52e-0439936435987950
Pubmed

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.

PRR12 CDX2 EP400

8.18e-0417736326206133
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

ZNF462 ZNF219 EP400 BRD4

8.39e-0441136435182466
InteractionTP53BP1 interactions

PRR12 SETD1A HNRNPUL1 EP400 RFX1 VIRMA ZC3H4 CPSF6 MEF2A FOXK1 BRD4

1.32e-095333611int:TP53BP1
InteractionCTBP1 interactions

PRR12 FBXO11 ZNF219 EP400 VIRMA SOBP FOXK1 BRD4 PCLO HTT

1.57e-094063610int:CTBP1
InteractionEP300 interactions

SIK2 HOXA10 SETD1A CRTC1 CDX2 ATF5 HNRNPUL1 VIRMA ZC3H4 CPSF6 MEF2A FOXK1 BRD4 KAT6A ENAH

5.49e-0914013615int:EP300
InteractionHCFC1 interactions

SETD1A BOD1L1 CDX2 EP400 VIRMA CPSF6 FOXK1 BRD4

3.86e-08293368int:HCFC1
InteractionSP7 interactions

HOXA10 PRR12 FBN2 EP400 RFX1 MEF2A RBM20 FOXK1

5.13e-08304368int:SP7
InteractionCREBBP interactions

HOXA10 SETD1A CRTC1 CDX2 KDM6B VIRMA CPSF6 BRD4 HTT KAT6A

6.32e-085993610int:CREBBP
InteractionSETD2 interactions

CDX2 VIRMA CPSF6 BRD4 HTT KAT6A

1.33e-07135366int:SETD2
InteractionKDM6A interactions

SETD1A BOD1L1 VIRMA FOXK1 BRD4 HTT

3.92e-07162366int:KDM6A
InteractionPRMT2 interactions

SETD1A HNRNPUL1 KDM6B ZNF341 HTT

5.67e-0791365int:PRMT2
InteractionAR interactions

ZNF462 PRR12 HNRNPUL1 EP400 VIRMA ZC3H4 CPSF6 MEF2A FOXG1 FOXK1 BRD4

7.51e-079923611int:AR
InteractionTFCP2L1 interactions

ZNF462 CDX2 EP400 PEG10 BRD4

8.63e-0799365int:TFCP2L1
InteractionKDM5B interactions

CDX2 VIRMA FOXG1 BRD4 HTT

9.07e-07100365int:KDM5B
InteractionPRPF40A interactions

CDX2 HNRNPUL1 ZNF341 VIRMA CPSF6 BRD4 HTT ENAH

9.49e-07446368int:PRPF40A
InteractionBAG2 interactions

SIK2 SETD1A BOD1L1 RFX1 VIRMA FOXK1 BRD4 HTT ENAH

1.07e-06622369int:BAG2
InteractionKLF12 interactions

SETD1A HNRNPUL1 EP400 RFX1 VIRMA FOXK1

1.13e-06194366int:KLF12
InteractionKLF5 interactions

PRR12 CDX2 EP400 RBM20 FOXK1 BRD4

1.16e-06195366int:KLF5
InteractionKMT2A interactions

HOXA10 SETD1A BOD1L1 KDM6B VIRMA BRD4 KAT6A

1.18e-06314367int:KMT2A
InteractionSNRNP40 interactions

ZNF462 HNRNPUL1 EP400 VIRMA ZC3H4 CPSF6 RBM20 BRD4 KAT6A

1.30e-06637369int:SNRNP40
InteractionFEV interactions

ZNF462 PRR12 SETD1A EP400 RFX1 FOXK1

1.47e-06203366int:FEV
InteractionWDR82 interactions

SETD1A BOD1L1 ZC3H4 CPSF6 BRD4 HTT

1.94e-06213366int:WDR82
InteractionPHF20 interactions

SETD1A KDM6B VIRMA HTT

2.36e-0653364int:PHF20
InteractionSYMPK interactions

VIRMA CPSF6 FOXG1 BRD4 HTT KAT6A

2.67e-06225366int:SYMPK
InteractionELF1 interactions

SETD1A HNRNPUL1 EP400 VIRMA FOXK1

2.85e-06126365int:ELF1
InteractionKDM1A interactions

ZNF462 PRR12 CRTC1 EP400 RFX1 VIRMA RBM20 FOXG1 BRD4 HTT

3.94e-069413610int:KDM1A
InteractionDHX40 interactions

ZNF462 VIRMA ZC3H4 CPSF6 RBM20 BRD4

4.78e-06249366int:DHX40
InteractionPOU5F1 interactions

ZNF462 CDX2 ZNF219 EP400 ZNF865 CPSF6 PEG10 BRD4

7.00e-06584368int:POU5F1
InteractionMEN1 interactions

ZNF462 PRR12 SETD1A BOD1L1 EP400 RFX1 ZC3H4 CPSF6 PEG10 FOXK1

8.69e-0610293610int:MEN1
InteractionHNRNPUL2 interactions

CDX2 HNRNPUL1 CPSF6 FOXG1 BRD4 KAT6A

1.16e-05291366int:HNRNPUL2
InteractionCBX3 interactions

ZNF462 SETD1A KDM6B EP400 RFX1 VIRMA ZC3H4 BRD4

1.46e-05646368int:CBX3
InteractionHDAC1 interactions

CRTC1 ZNF219 EP400 RFX1 VIRMA MEF2A RBM20 FOXG1 FOXK1 BRD4

1.66e-0511083610int:HDAC1
InteractionNANOG interactions

ZNF462 FBXO11 ZNF219 EP400 ZNF865 VIRMA PEG10

1.94e-05481367int:NANOG
InteractionHMGB1 interactions

HOXA10 CDX2 RFX1 VIRMA BRD4 HTT ENAH

2.07e-05486367int:HMGB1
InteractionKLF8 interactions

PRR12 SETD1A FBN2 HNRNPUL1 EP400 FOXK1

2.33e-05329366int:KLF8
InteractionEEF1D interactions

KDM6B VIRMA FOXG1 FOXK1 BRD4 HTT

2.49e-05333366int:EEF1D
InteractionH2BC21 interactions

PRR12 KDM6B EP400 VIRMA ZC3H4 BRD4 PCLO KAT6A

2.50e-05696368int:H2BC21
InteractionSOX9 interactions

PRR12 EP400 VIRMA BRD4

2.64e-0597364int:SOX9
InteractionNUP50 interactions

SETD1A BOD1L1 RFX1 VIRMA ZC3H4 BRD4

2.85e-05341366int:NUP50
InteractionKDM7A interactions

KDM6B VIRMA

3.09e-055362int:KDM7A
InteractionTCERG1 interactions

SETD1A CPSF6 FOXG1 BRD4 HTT

3.17e-05207365int:TCERG1
InteractionETV6 interactions

HNRNPUL1 VIRMA BRD4 KAT6A

3.60e-05105364int:ETV6
InteractionMETTL16 interactions

VIRMA CPSF6 BRD4

3.90e-0537363int:METTL16
InteractionH3-3A interactions

HOXA10 SETD1A BOD1L1 KDM6B RFX1 FOXK1 BRD4 KAT6A

4.21e-05749368int:H3-3A
InteractionPAX6 interactions

ZNF462 PRR12 CDX2 EP400 KCNC3 FOXK1

4.23e-05366366int:PAX6
InteractionNCOA3 interactions

ZNF219 RFX1 VIRMA FOXG1 BRD4

4.62e-05224365int:NCOA3
InteractionUSP24 interactions

KDM6B VIRMA FOXK1 HTT

4.64e-05112364int:USP24
InteractionTERF2IP interactions

SETD1A BOD1L1 EP400 RFX1 ZC3H4 BRD4 ENAH

4.66e-05552367int:TERF2IP
InteractionTBR1 interactions

PRR12 VIRMA FOXK1 BRD4

4.81e-05113364int:TBR1
InteractionELF4 interactions

SETD1A HNRNPUL1 EP400 FOXK1

5.15e-05115364int:ELF4
InteractionDDX5 interactions

SETD1A HNRNPUL1 VIRMA CPSF6 BRD4 HTT KAT6A

5.58e-05568367int:DDX5
InteractionSULF2 interactions

SETD1A BOD1L1 VIRMA BRD4

5.88e-05119364int:SULF2
InteractionFICD interactions

VIRMA HTT

6.48e-057362int:FICD
InteractionASCL1 interactions

KDM6B MEF2A BRD4

7.05e-0545363int:ASCL1
InteractionMAD2L1 interactions

PRR12 SETD1A BOD1L1 BRD4 KAT6A

8.07e-05252365int:MAD2L1
InteractionMYL6 interactions

SIK2 BOD1L1 VIRMA BRD4 HTT

8.53e-05255365int:MYL6
InteractionCPSF1 interactions

HNRNPUL1 VIRMA CPSF6 BRD4 KAT6A

8.53e-05255365int:CPSF1
InteractionFOXP1 interactions

HNRNPUL1 RFX1 VIRMA CPSF6 HTT

8.69e-05256365int:FOXP1
InteractionATXN10 interactions

VIRMA PEG10 BRD4 HTT

1.02e-04137364int:ATXN10
InteractionASH2L interactions

SETD1A BOD1L1 KDM6B FOXK1 HTT

1.02e-04265365int:ASH2L
InteractionARIH1 interactions

HOXA10 FBXO11 BOD1L1 FOXK1 BRD4

1.04e-04266365int:ARIH1
InteractionKDM5C interactions

EP400 VIRMA BRD4 HTT

1.08e-04139364int:KDM5C
InteractionRNF2 interactions

HNRNPUL1 EP400 RFX1 VIRMA ZC3H4 PEG10 BRD4 PCLO

1.17e-04866368int:RNF2
InteractionNCOA6 interactions

SETD1A BOD1L1 VIRMA HTT

1.27e-04145364int:NCOA6
InteractionDAZL interactions

HNRNPUL1 CPSF6 RBM20 PEG10

1.27e-04145364int:DAZL
InteractionZC3H4 interactions

VIRMA ZC3H4 CPSF6 BRD4

1.33e-04147364int:ZC3H4
InteractionBOD1L1 interactions

SETD1A BOD1L1 VIRMA BRD4

1.41e-04149364int:BOD1L1
InteractionZFP41 interactions

FBN2 VIRMA ZC3H4

1.43e-0457363int:ZFP41
InteractionAP3M1 interactions

VIRMA BRD4 HTT KAT6A

1.44e-04150364int:AP3M1
InteractionADAR interactions

EP400 VIRMA CPSF6 FOXG1 BRD4

1.46e-04286365int:ADAR
InteractionRBBP5 interactions

SETD1A BOD1L1 KDM6B VIRMA BRD4

1.49e-04287365int:RBBP5
InteractionSNRNP200 interactions

BOD1L1 VIRMA CPSF6 FOXG1 BRD4 KAT6A

1.49e-04460366int:SNRNP200
InteractionH1-2 interactions

BOD1L1 KDM6B EP400 VIRMA BRD4 HTT KAT6A

1.51e-04666367int:H1-2
InteractionCELF1 interactions

HNRNPUL1 ZC3H4 CPSF6 RBM20 BRD4

1.51e-04288365int:CELF1
InteractionPYGB interactions

VIRMA FOXK1 BRD4 HTT

1.52e-04152364int:PYGB
InteractionSMARCA4 interactions

CDX2 KDM6B EP400 VIRMA BRD4 KAT6A

1.53e-04462366int:SMARCA4
InteractionPRPF3 interactions

FBXO11 VIRMA CPSF6 BRD4 KAT6A

1.58e-04291365int:PRPF3
InteractionZC3H6 interactions

VIRMA ZC3H4

1.69e-0411362int:ZC3H6
InteractionPFN2 interactions

KDM6B PCLO HTT ENAH

1.81e-04159364int:PFN2
InteractionTOP3B interactions

PRR12 SETD1A KDM6B EP400 ZNF865 ZNF341 FOXK1 BRD4 HTT KAT6A

1.81e-0414703610int:TOP3B
InteractionXRCC6 interactions

BOD1L1 CDX2 EP400 VIRMA ZC3H4 CPSF6 BRD4 HTT

1.88e-04928368int:XRCC6
InteractionPSMA1 interactions

BOD1L1 KDM6B VIRMA FOXK1 BRD4 HTT

1.88e-04480366int:PSMA1
InteractionSNRPA interactions

HNRNPUL1 VIRMA ZC3H4 PEG10 BRD4 HTT

1.92e-04482366int:SNRPA
InteractionIPO7 interactions

HOXA10 CDX2 VIRMA BRD4 HTT

1.94e-04304365int:IPO7
InteractionACTC1 interactions

BOD1L1 EP400 VIRMA ZC3H4 CPSF6 BRD4 ENAH

1.95e-04694367int:ACTC1
InteractionCCDC15 interactions

VIRMA MEF2A

2.02e-0412362int:CCDC15
InteractionSOBP interactions

VIRMA SOBP

2.02e-0412362int:SOBP
InteractionCSTF2 interactions

SLC25A41 ZNF341 CPSF6 BRD4

2.08e-04165364int:CSTF2
InteractionPPIL4 interactions

CPSF6 BRD4 HTT KAT6A

2.08e-04165364int:PPIL4
InteractionBRPF3 interactions

HOXA10 VIRMA BRD4 KAT6A

2.13e-04166364int:BRPF3
InteractionSAP30 interactions

ZNF219 FOXK1 BRD4 HTT

2.18e-04167364int:SAP30
InteractionSSU72 interactions

CPSF6 BRD4 HTT

2.22e-0466363int:SSU72
InteractionKDM3A interactions

KDM6B VIRMA BRD4

2.32e-0467363int:KDM3A
InteractionPHF5A interactions

SETD1A CPSF6 BRD4 KAT6A

2.38e-04171364int:PHF5A
InteractionKIAA0513 interactions

VIRMA FOXK1

2.39e-0413362int:KIAA0513
InteractionSVEP1 interactions

FBN2 VIRMA

2.39e-0413362int:SVEP1
InteractionCSNK2A2 interactions

ZNF219 EP400 VIRMA ZC3H4 BRD4 HTT KAT6A

2.40e-04718367int:CSNK2A2
InteractionSMG7 interactions

PRR12 HNRNPUL1 ZC3H4 CPSF6 RBM20

2.43e-04319365int:SMG7
InteractionRBBP7 interactions

ZNF462 ZNF219 EP400 VIRMA FOXK1 BRD4

2.52e-04507366int:RBBP7
InteractionETV4 interactions

PRR12 HNRNPUL1 HTT

2.53e-0469363int:ETV4
InteractionRBM25 interactions

VIRMA CPSF6 PEG10 BRD4 HTT

2.57e-04323365int:RBM25
InteractionPFN1 interactions

BOD1L1 VIRMA CPSF6 PCLO HTT ENAH

2.58e-04509366int:PFN1
CytobandEnsembl 112 genes in cytogenetic band chr19q13

PRR12 ATF5 HNRNPUL1 KCNC3 ZNF865 ZC3H4

3.02e-041192366chr19q13
CytobandEnsembl 112 genes in cytogenetic band chr19p13

CRTC1 SLC25A41 HCN2 RFX1 BRD4

3.76e-04797365chr19p13
Cytoband19p13.1

RFX1 BRD4

6.59e-044836219p13.1
Cytoband19q13.33

PRR12 KCNC3

3.16e-0310636219q13.33
CytobandEnsembl 112 genes in cytogenetic band chr5q23

ADAMTS19 FBN2

3.83e-03117362chr5q23
CytobandEnsembl 112 genes in cytogenetic band chr7q21

PEG10 PCLO

8.64e-03178362chr7q21
GeneFamilyForkhead boxes

FOXG1 FOXK1

1.73e-0343262508
GeneFamilyHOXL subclass homeoboxes

HOXA10 CDX2

2.52e-0352262518
GeneFamilyRNA binding motif containing

SETD1A CPSF6 RBM20

3.43e-03213263725
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF462 ZNF219 ZNF865 ZNF341

1.84e-0271826428
ToppCell10x5'-Lung-Lymphocytic_T_CD4/8-lo-Trm_Tgd|Lung / Manually curated celltypes from each tissue

SIK2 HOXA10 CRTC1 PEG10

9.83e-06167364dcbcc658082910838c8082d71a64917055086cc4
ToppCellControl-Myeloid-MoAM1,_IL1R2|Control / Condition, Lineage and Cell class

FBN2 ATF5 MEF2A ENAH

9.83e-06167364ab6029ba037b6a499da8758864c44e174cde5587
ToppCellfacs-Heart-RA-18m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDX2 HNRNPUL1 KDM6B EP400

1.26e-05178364b505e2550860e777535ee95f29c936242fd607f1
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PRR12 FOXK1 BRD4 HTT

1.67e-05191364cadb7a9de16f4bb21606de0e25cddd2d748c7f0b
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ZNF462 CPSF6 FOXG1 ENAH

1.84e-051963648faac7fbdee3a9297023c3151ef1751605413e44
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF462 SOBP RBM20 FOXK1

1.96e-051993644217b9e66c5374461e84bdb893ab650f148286c8
DiseaseIntellectual Disability

ZNF462 PRR12 SETD1A KDM6B FOXG1 BRD4 HTT

8.14e-07447357C3714756
Diseasered blood cell density measurement

ZNF462 CRTC1 ZNF219 KDM6B EP400 ZC3H4 BRD4

6.64e-05880357EFO_0007978
Diseasevital capacity

HOXA10 ADAMTS19 ZNF341 RBM20 FOXK1 BRD4 PCLO

5.34e-041236357EFO_0004312
DiseaseAgents acting on the renin-angiotensin system use measurement

SIK2 FBN2 KDM6B CPSF6

6.47e-04335354EFO_0009931
DiseaseDiuretic use measurement

SIK2 FBN2 CPSF6

1.06e-03169353EFO_0009928
DiseaseAdult Medulloblastoma

BRD4 KAT6A

1.20e-0343352C0278876
DiseaseChildhood Medulloblastoma

BRD4 KAT6A

1.20e-0343352C0278510
DiseaseMelanotic medulloblastoma

BRD4 KAT6A

1.20e-0343352C1275668
DiseaseMedullomyoblastoma

BRD4 KAT6A

1.20e-0343352C0205833
Diseasedilated cardiomyopathy (is_implicated_in)

MEF2A RBM20

1.20e-0343352DOID:12930 (is_implicated_in)
DiseaseDesmoplastic Medulloblastoma

BRD4 KAT6A

1.20e-0343352C0751291
DiseaseMedulloblastoma

BRD4 KAT6A

1.62e-0350352C0025149
Diseaseinterleukin 12 measurement

ZNF462 KCNC3

1.81e-0353352EFO_0004753
Diseasevascular endothelial growth factor measurement

ZNF462 KCNC3

2.02e-0356352EFO_0004762
Diseasecytokine measurement

FBXO11 FBN2 HCN2 CPSF6

2.10e-03461354EFO_0004873
DiseaseMicrocephaly

FOXG1 BRD4

2.88e-0367352C0025958
DiseaseNonorganic psychosis

SOBP MEF2A

3.05e-0369352C0349204
Diseaseintellectual disability (implicated_via_orthology)

BOD1L1 MEF2A

3.59e-0375352DOID:1059 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
AQPPPPQPQPPPPPQ

EP400

2541

Q96L91
PQPQPPPPPQQPPPP

EP400

2546

Q96L91
PPPPQQPPPPLPQPQ

EP400

2551

Q96L91
QPPQPPPPPPQPPQP

CDX2

256

Q99626
PPPPPQPPQPQPGPL

CDX2

261

Q99626
PPVPPQPQPPPAPAP

BRD4

251

O60885
QPPPPPQQPPPPPPP

BRD4

756

O60885
PPPPPQQQQQPPPPP

BRD4

766

O60885
QQQPPPPPPPQPQPP

BRD4

971

O60885
PPPQQPPPPSPPQPS

ATF5

181

Q9Y2D1
MQQPPPPPQPPPPPQ

RBM20

41

Q5T481
QPPPPPQPPPSPPPA

ADAMTS19

141

Q8TE59
PPSQPQPPPPPPPSP

KDM6B

786

O15054
PPPPQQQQPPPPPPP

FOXG1

66

P55316
QQQPPPPPPPAPQPP

FOXG1

71

P55316
ISAQPPPPPPPPPPP

PCLO

2401

Q9Y6V0
QPPVPQYPPPQPPPP

PEG10

681

Q86TG7
QYPPPQPPPPPPPPP

PEG10

686

Q86TG7
DGPPPPPQQQPPPPP

HOXA10

131

P31260
PPQQQPPPPPQPPQP

HOXA10

136

P31260
PPPPPQPQPQPPQPQ

MEF2A

431

Q02078
PPPPPPQQPQPPPPQ

KAT6A

1651

Q92794
PPPPQPQPAPQPPPP

KAT6A

1661

Q92794
QPQPPPPAPPPPPPQ

BOD1L1

6

Q8NFC6
PPAPPPPPPQPQPQP

BOD1L1

11

Q8NFC6
PPPPQPQPQPPPPPP

BOD1L1

16

Q8NFC6
QQQPPPPPPPPPPPQ

HTT

36

P42858
LLPQPQPPPPPPPPP

HTT

61

P42858
QPPPPPPPPPPGPAV

HTT

66

P42858
PPGPPPPQQGPPPPP

CPSF6

306

Q16630
QQPPPQPQPPPPPPP

CRTC1

361

Q6UUV9
PPPPPASQQPPPPPP

CRTC1

371

Q6UUV9
QPPPPPPPPPPLPQE

FBXO11

56

Q86XK2
PAPAQPQPPPGPPPP

FOXK1

41

P85037
GPPPPPPPPPLPNQV

ENAH

346

Q8N8S7
PPPPPLPNQVPPPPP

ENAH

351

Q8N8S7
QPPPPKPPRPQPPPQ

FBN2

31

P35556
GPPPPPPPAPPQQQP

HCN2

21

Q9UL51
PPPAPPQQQPPPPPP

HCN2

26

Q9UL51
PQQQPPPPPPPAPPP

HCN2

31

Q9UL51
PPPQQPPPPQPPPQQ

HNRNPUL1

696

Q9BUJ2
PPPPQPPPQQPPPPP

HNRNPUL1

701

Q9BUJ2
APPQAQPQPPPPPPP

RFX1

21

P22670
QPQPPPPPPPAAPQP

RFX1

26

P22670
PPPPPAAPQPPQPPT

RFX1

31

P22670
QQPPPPPPPPPPRQP

SIK2

821

Q9H0K1
PPPQPPPPPPSWNPG

SLC25A41

31

Q8N5S1
QAAPPPPPPPPPPPA

PRR12

1036

Q9ULL5
PPPAPTPQPQPPPPP

PRR12

1461

Q9ULL5
TPQPQPPPPPPPPQP

PRR12

1466

Q9ULL5
PAPTPPQQPPPPPPP

SETD1A

596

O15047
PPPPQPPPPPPQSLG

ZNF341

191

Q9BYN7
APGPPPQPPPQPPPP

ZNF865

61

P0CJ78
PPEQPPPPPPPAPPK

SOBP

741

A7XYQ1
PPPPPPPGPPQMPMP

ZC3H4

546

Q9UPT8
QPPQPPPPPPPPPPS

ZNF462

541

Q96JM2
PPPPPPPPPSQPQPL

ZNF462

546

Q96JM2
PPPPPPPPPQPQPSL

VIRMA

141

Q69YN4
PPPQPQPQPPPQPEP

ZNF219

226

Q9P2Y4
PAPPPQPPESPPPPP

KCNC3

21

Q14003