Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	TBC1D3E ARHGAP32 TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	7.03e-07	279	141	12	GO:0005096
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	TBC1D3E ARHGAP32 TBC1D3 TBC1D3H TBC1D3L TBC1D3D DOCK8 TBC1D3C TBC1D3B LAMTOR1 TBC1D3I TBC1D3G TBC1D3K TBC1D3F	1.47e-05	507	141	14	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	TBC1D3E ARHGAP32 TBC1D3 TBC1D3H TBC1D3L TBC1D3D DOCK8 TBC1D3C TBC1D3B LAMTOR1 TBC1D3I TBC1D3G TBC1D3K TBC1D3F	1.47e-05	507	141	14	GO:0030695
GeneOntologyMolecularFunction	double-stranded RNA binding	RC3H2 AGO2 ILF3 AGO4 TARBP2	2.28e-04	78	141	5	GO:0003725
GeneOntologyBiologicalProcess	activation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	1.91e-10	109	139	11	GO:0090630
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	SEMA4D TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D DOCK8 TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	1.12e-08	244	139	13	GO:0043547
GeneOntologyBiologicalProcess	regulation of GTPase activity	SEMA4D TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D DOCK8 TBC1D3C TBC1D3B AMOT TBC1D3I TBC1D3G TBC1D3K TBC1D3F	6.39e-08	335	139	14	GO:0043087
GeneOntologyBiologicalProcess	negative regulation of phagocytosis, engulfment	SIGLEC12 SIGLEC9 SIGLEC7	2.97e-06	5	139	3	GO:0060101
GeneOntologyBiologicalProcess	negative regulation of membrane invagination	SIGLEC12 SIGLEC9 SIGLEC7	5.90e-06	6	139	3	GO:1905154
GeneOntologyBiologicalProcess	positive regulation of hydrolase activity	SEMA4D TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D DOCK8 TBC1D3C TBC1D3B TBC1D3I TBC1D3G TNFSF15 TBC1D3K TBC1D3F	7.26e-06	499	139	14	GO:0051345
GeneOntologyBiologicalProcess	RISC complex assembly	AGO2 AGO4 TARBP2	3.47e-05	10	139	3	GO:0070922
GeneOntologyBiologicalProcess	regulation of hydrolase activity	SEMA4D TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D DOCK8 TBC1D3C TBC1D3B AMOT TBC1D3I PZP TBC1D3G TNFSF15 MRTFA TBC1D3K TBC1D3F	8.87e-05	878	139	17	GO:0051336
GeneOntologyBiologicalProcess	miRNA metabolic process	RC3H2 AGO2 AGO4 NFIB NOTCH2 MRTFA	1.56e-04	119	139	6	GO:0010586
GeneOntologyBiologicalProcess	pre-miRNA processing	AGO2 AGO4 TARBP2	1.90e-04	17	139	3	GO:0031054
GeneOntologyBiologicalProcess	positive regulation of catalytic activity	SEMA4D TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D DOCK8 TEK TBC1D3C TBC1D3B TENM1 MAP3K13 TBC1D3I TBC1D3G TNFSF15 NOTCH2 TBC1D3K TBC1D3F	1.92e-04	1028	139	18	GO:0043085
GeneOntologyCellularComponent	RISC-loading complex	AGO2 AGO4 TARBP2	3.56e-05	10	142	3	GO:0070578
HumanPheno	Cryptophthalmos	FRAS1 MAB21L2 FREM2	1.44e-05	6	47	3	HP:0001126
Domain	TBC	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	2.59e-12	49	140	10	SM00164
Domain	RabGAP-TBC	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	6.00e-12	53	140	10	PF00566
Domain	Rab-GTPase-TBC_dom	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	8.88e-12	55	140	10	IPR000195
Domain	TBC_RABGAP	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	8.88e-12	55	140	10	PS50086
Domain	Calx_beta	FRAS1 FREM3 FREM2	2.25e-05	8	140	3	SM00237
Domain	Calx_beta	FRAS1 FREM3 FREM2	3.35e-05	9	140	3	IPR003644
Domain	Calx-beta	FRAS1 FREM3 FREM2	3.35e-05	9	140	3	PF03160
Domain	ZnF_C2HC	RBBP6 SLU7 ZCCHC2 RECQL4 TOP3A	5.67e-05	55	140	5	SM00343
Domain	Znf_CCHC	RBBP6 SLU7 ZCCHC2 RECQL4 TOP3A	5.67e-05	55	140	5	IPR001878
Domain	IGc2	SIGLEC12 SEMA4D MYOM1 LRIG2 SIGLEC7 PTPRF HMCN1 AMIGO3 ALPK2	7.12e-05	235	140	9	SM00408
Domain	Ig_sub2	SIGLEC12 SEMA4D MYOM1 LRIG2 SIGLEC7 PTPRF HMCN1 AMIGO3 ALPK2	7.12e-05	235	140	9	IPR003598
Domain	Topo_IA_cen_sub2	RBBP6 TOP3A	1.67e-04	3	140	2	IPR013825
Domain	IG_LIKE	SIGLEC12 SEMA4D MYOM1 SIGLEC9 TEK LRIG2 TREML4 SIGLEC7 PTPRF HMCN1 AMIGO3 ALPK2	3.31e-04	491	140	12	PS50835
Domain	VDCC_a2/dsu	CACNA2D1 CACNA2D2	3.31e-04	4	140	2	IPR013680
Domain	VGCC_alpha2	CACNA2D1 CACNA2D2	3.31e-04	4	140	2	PF08473
Domain	Argonaute_N	AGO2 AGO4	3.31e-04	4	140	2	IPR032474
Domain	Argonaute_Mid_dom	AGO2 AGO4	3.31e-04	4	140	2	IPR032473
Domain	ArgoL2	AGO2 AGO4	3.31e-04	4	140	2	IPR032472
Domain	ArgoN	AGO2 AGO4	3.31e-04	4	140	2	PF16486
Domain	ArgoMid	AGO2 AGO4	3.31e-04	4	140	2	PF16487
Domain	ArgoL2	AGO2 AGO4	3.31e-04	4	140	2	PF16488
Domain	IG	SIGLEC12 SEMA4D MYOM1 SIGLEC9 LRIG2 TREML4 SIGLEC7 PTPRF HMCN1 AMIGO3 ALPK2	3.36e-04	421	140	11	SM00409
Domain	Ig_sub	SIGLEC12 SEMA4D MYOM1 SIGLEC9 LRIG2 TREML4 SIGLEC7 PTPRF HMCN1 AMIGO3 ALPK2	3.36e-04	421	140	11	IPR003599
Domain	Ig-like_dom	SIGLEC12 SEMA4D MYOM1 SIGLEC9 TEK LRIG2 TREML4 SIGLEC7 PTPRF HMCN1 AMIGO3 ALPK2	4.11e-04	503	140	12	IPR007110
Domain	VWA_N	CACNA2D1 CACNA2D2	5.50e-04	5	140	2	IPR013608
Domain	VWA_N	CACNA2D1 CACNA2D2	5.50e-04	5	140	2	PF08399
Domain	Mab-21-like_1/2	MAB21L2 MAB21L1	5.50e-04	5	140	2	IPR020950
Domain	DUF1785	AGO2 AGO4	5.50e-04	5	140	2	SM01163
Domain	Ig_I-set	SIGLEC12 MYOM1 LRIG2 SIGLEC7 PTPRF HMCN1 ALPK2	5.81e-04	190	140	7	IPR013098
Domain	I-set	SIGLEC12 MYOM1 LRIG2 SIGLEC7 PTPRF HMCN1 ALPK2	5.81e-04	190	140	7	PF07679
Domain	ig	SIGLEC12 SEMA4D MYOM1 SIGLEC9 LRIG2 SIGLEC7 HMCN1	5.81e-04	190	140	7	PF00047
Domain	Immunoglobulin	SIGLEC12 SEMA4D MYOM1 SIGLEC9 LRIG2 SIGLEC7 HMCN1	5.81e-04	190	140	7	IPR013151
Domain	ArgoL1	AGO2 AGO4	8.20e-04	6	140	2	PF08699
Domain	ArgoL1	AGO2 AGO4	8.20e-04	6	140	2	IPR014811
Domain	Growth_fac_rcpt_	FRAS1 TEK HMCN1 ELAPOR1 LTBP1 NOTCH2	1.15e-03	156	140	6	IPR009030
Domain	-	SIGLEC12 SEMA4D MYOM1 SIGLEC9 TEK LRIG2 TREML4 SIGLEC7 PTPRF HMCN1 AMIGO3 IL5RA ALPK2	1.46e-03	663	140	13	2.60.40.10
Domain	PIWI	AGO2 AGO4	1.52e-03	8	140	2	PS50822
Domain	Piwi	AGO2 AGO4	1.52e-03	8	140	2	SM00950
Domain	Villin/Gelsolin	CAPG VILL	1.52e-03	8	140	2	IPR007122
Domain	Piwi	AGO2 AGO4	1.52e-03	8	140	2	PF02171
Domain	Piwi	AGO2 AGO4	1.52e-03	8	140	2	IPR003165
Domain	GEL	CAPG VILL	1.52e-03	8	140	2	SM00262
Domain	PAZ	AGO2 AGO4	1.94e-03	9	140	2	PS50821
Domain	PAZ	AGO2 AGO4	1.94e-03	9	140	2	SM00949
Domain	PAZ	AGO2 AGO4	1.94e-03	9	140	2	PF02170
Domain	PAZ_dom	AGO2 AGO4	1.94e-03	9	140	2	IPR003100
Domain	Cadherin	PCDHGB7 FREM3 FREM2 CDH24 CDH20	1.96e-03	118	140	5	IPR002126
Domain	ZF_CCHC	RBBP6 SLU7 ZCCHC2	2.26e-03	35	140	3	PS50158
Domain	-	CACNA2D1 CACNA2D2 CFB HMCN1	2.32e-03	74	140	4	3.40.50.410
Domain	Ig-like_fold	SIGLEC12 SEMA4D MYOM1 SIGLEC9 TEK LRIG2 TREML4 SIGLEC7 PTPRF HMCN1 AMIGO3 IL5RA ALPK2	2.53e-03	706	140	13	IPR013783
Domain	VWFA	CACNA2D1 CACNA2D2 CFB HMCN1	3.37e-03	82	140	4	PS50234
Domain	Mab-21	MAB21L2 MAB21L1	3.51e-03	12	140	2	PF03281
Domain	Mab-21	MAB21L2 MAB21L1	3.51e-03	12	140	2	SM01265
Domain	Mab-21_dom	MAB21L2 MAB21L1	3.51e-03	12	140	2	IPR024810
Domain	C2-set_2	SIGLEC12 SIGLEC9 SIGLEC7	3.57e-03	41	140	3	PF08205
Domain	CD80_C2-set	SIGLEC12 SIGLEC9 SIGLEC7	3.57e-03	41	140	3	IPR013162
Domain	Homeodomain-like	HNF1A IRX3 CERS5 HOXD4 JRK SMARCC2 DLX3 CUX1	3.60e-03	332	140	8	IPR009057
Domain	VWA	CACNA2D1 CACNA2D2 CFB HMCN1	3.67e-03	84	140	4	SM00327
Domain	Gelsolin	CAPG VILL	4.79e-03	14	140	2	PF00626
Domain	Gelsolin-like_dom	CAPG VILL	4.79e-03	14	140	2	IPR007123
Domain	-	HNF1A IRX3 CERS5 HOXD4 SMARCC2 DLX3 CUX1	5.53e-03	283	140	7	1.10.10.60
Domain	Acyltransferase	GPAT3 LCLAT1	6.25e-03	16	140	2	PF01553
Domain	VWF_A	CACNA2D1 CACNA2D2 CFB HMCN1	6.57e-03	99	140	4	IPR002035
Domain	PlsC	GPAT3 LCLAT1	7.05e-03	17	140	2	SM00563
Domain	Plipid/glycerol_acylTrfase	GPAT3 LCLAT1	7.05e-03	17	140	2	IPR002123
Pathway	WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K	2.70e-08	99	98	9	M46448
Pathway	REACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION	AGO2 ILF3 CDH24 AGO4 AMOT	2.54e-06	32	98	5	M48012
Pathway	REACTOME_MICRORNA_MIRNA_BIOGENESIS	AGO2 AGO4 TARBP2	6.42e-06	6	98	3	MM14818
Pathway	REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS	AGO2 AGO4 TARBP2	1.78e-05	8	98	3	MM15082
Pathway	REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS	AGO2 AGO4 TARBP2	2.65e-05	9	98	3	M27340
Pathway	REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS	AGO2 ILF3 CDH24 AGO4 AMOT	5.01e-05	58	98	5	M11980
Pathway	REACTOME_GENE_SILENCING_BY_RNA	AGO2 RAE1 AGO4 TARBP2	3.66e-04	49	98	4	MM14837
Pathway	KEGG_MEDICUS_REFERENCE_CARDIAC_TYPE_VGCC_RYR_SIGNALING	CACNA2D1 CACNA2D2 RYR2	3.96e-04	21	98	3	M47950
Pathway	REACTOME_CELL_CELL_JUNCTION_ORGANIZATION	AGO2 ILF3 CDH24 AGO4 AMOT	4.04e-04	90	98	5	M820
Pathway	BIOCARTA_DICER_PATHWAY	AGO2 AGO4	4.72e-04	5	98	2	M22079
Pubmed	TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	3.83e-27	11	143	11	16863688
Pubmed	DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.	TBC1D3E TBC1D3 TBC1D3H TBC1D3D TBC1D3B LRRC37B TBC1D3G TBC1D3F	8.04e-10	74	143	8	16625196
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DMXL2 FRAS1 PLOD3 ILF3 PDE7A POLRMT GPAT3 SLU7 TRAPPC8 PRPF8 PCF11 LRIG2 GUF1 CASKIN2 PES1 DNAJC5G LAMTOR1 ANKRD52 TARBP2 CUX1 AQR NOTCH2 NOL8	4.46e-08	1487	143	23	33957083
Pubmed	Expression of Fraser syndrome genes in normal and polycystic murine kidneys.	FRAS1 FREM3 FREM2	6.81e-08	3	143	3	21993971
Pubmed	Human-specific elimination of epithelial Siglec-XII suppresses the risk of inflammation-driven colorectal cancers.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	38990656
Pubmed	Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	27494323
Pubmed	Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	37460871
Pubmed	Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	24391502
Pubmed	The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	38454157
Pubmed	Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	30130255
Pubmed	Siglec receptors impact mammalian lifespan by modulating oxidative stress.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	25846707
Pubmed	Immunosuppressive Siglec-E ligands on mouse aorta are up-regulated by LPS via NF-κB pathway.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	31918287
Pubmed	Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E).	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	19552697
Pubmed	Targeting the Siglec-sialic acid axis promotes antitumor immune responses in preclinical models of glioblastoma.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	37467314
Pubmed	Polysialic acid promotes remyelination in cerebellar slice cultures by Siglec-E-dependent modulation of microglia polarization.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	37492129
Pubmed	The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	33007530
Pubmed	Differential localization profile of Fras1/Frem proteins in epithelial basement membranes of newborn and adult mice.	FRAS1 FREM3 FREM2	2.71e-07	4	143	3	18563433
Pubmed	Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	27920204
Pubmed	Early murine T-lymphocyte activation is accompanied by a switch from N-Glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	21835922
Pubmed	Segmental and restricted localization pattern of Fras1 in the developing meningeal basement membrane in mouse.	FRAS1 FREM3 FREM2	2.71e-07	4	143	3	24101214
Pubmed	Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	34155121
Pubmed	Polysialic acid and Siglec-E orchestrate negative feedback regulation of microglia activation.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	32725371
Pubmed	PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.	TBC1D3 TBC1D3D TBC1D3F	2.71e-07	4	143	3	12359748
Pubmed	Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	30910970
Pubmed	O-Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli-Containing Vacuoles in Macrophage-Like Cells.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	34878295
Pubmed	Ablation of Siglec-E augments brain inflammation and ischemic injury.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	35858866
Pubmed	Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.	TBC1D3 TBC1D3D TBC1D3F	2.71e-07	4	143	3	8406013
Pubmed	Involvement of sulfates from cruzipain, a major antigen of Trypanosoma cruzi, in the interaction with immunomodulatory molecule Siglec-E.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	26047932
Pubmed	Siglec genes confer resistance to systemic lupus erythematosus in humans and mice.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	29503442
Pubmed	The role of Dicer protein partners in the processing of microRNA precursors.	AGO2 RBBP6 TARBP2	2.71e-07	4	143	3	22163034
Pubmed	Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer.	SIGLEC12 SIGLEC9 SIGLEC7	2.71e-07	4	143	3	25225409
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	SEMA4D RC3H2 RAE1 MYO7A RBBP6 PRPF8 CYFIP1 NFIB GLI3 PES1 NOTCH2	3.04e-07	358	143	11	32460013
Pubmed	The Tre2 (USP6) oncogene is a hominoid-specific gene.	TBC1D3 TBC1D3D TBC1D3C	6.77e-07	5	143	3	12604796
Pubmed	Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung.	SIGLEC12 SIGLEC9 SIGLEC7	6.77e-07	5	143	3	24895121
Pubmed	Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production.	SIGLEC12 SIGLEC9 SIGLEC7	6.77e-07	5	143	3	19933851
Pubmed	Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264.	SIGLEC12 SIGLEC9 SIGLEC7	6.77e-07	5	143	3	26540411
Pubmed	The prognostic impact of SIGLEC5-induced impairment of CD8+ T cell activation in sepsis.	SIGLEC12 SIGLEC9 SIGLEC7	6.77e-07	5	143	3	37890368
Pubmed	Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis-associated oxidative burst.	SIGLEC12 SIGLEC9 SIGLEC7	6.77e-07	5	143	3	24227736
Pubmed	Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development.	FRAS1 FREM3 FREM2	6.77e-07	5	143	3	17251066
Pubmed	Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.	TBC1D3 TBC1D3D TBC1D3F	6.77e-07	5	143	3	8471161
Pubmed	A soluble form of Siglec-9 provides an antitumor benefit against mammary tumor cells expressing MUC1 in transgenic mice.	SIGLEC12 SIGLEC9 SIGLEC7	6.77e-07	5	143	3	24924635
Pubmed	Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth.	SIGLEC12 SIGLEC9 SIGLEC7	6.77e-07	5	143	3	24045940
Pubmed	Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis.	SIGLEC12 SIGLEC9 SIGLEC7	6.77e-07	5	143	3	27619995
Pubmed	Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression.	SIGLEC12 SIGLEC9 SIGLEC7	6.77e-07	5	143	3	16857734
Pubmed	Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa.	FRAS1 FREM3 FREM2	6.77e-07	5	143	3	17596926
Pubmed	Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling.	SIGLEC12 SIGLEC9 SIGLEC7	1.35e-06	6	143	3	23315163
Pubmed	Molecular cloning of MIS, a myeloid inhibitory siglec, that binds protein-tyrosine phosphatases SHP-1 and SHP-2.	SIGLEC12 SIGLEC9 SIGLEC7	1.35e-06	6	143	3	11278955
Pubmed	Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1.	FRAS1 FREM3 FREM2	1.35e-06	6	143	3	17462874
Pubmed	mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2.	SIGLEC12 SIGLEC9 SIGLEC7	2.35e-06	7	143	3	11171044
Pubmed	The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils.	SIGLEC12 SIGLEC9 SIGLEC7	2.35e-06	7	143	3	15048729
Pubmed	[Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins].	SIGLEC12 SIGLEC9 SIGLEC7	2.35e-06	7	143	3	18453149
Pubmed	Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.	SIGLEC12 SIGLEC9 SIGLEC7	2.35e-06	7	143	3	28100677
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	ILF3 RAE1 RBBP6 POLRMT PRPF8 PCF11 CYFIP1 NFIB JRK PES1 NUFIP2 SMARCC2 CUX1 AQR NOL8	2.36e-06	847	143	15	35850772
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ARHGAP32 MYO7A GPAT3 SLU7 NEB FER1L6 RYR2 CYFIP1 PTPRN2 NFIB SMARCC2 ANKRD52 CUX1	2.56e-06	638	143	13	31182584
Pubmed	Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1.	SIGLEC12 SIGLEC9 SIGLEC7	3.75e-06	8	143	3	25187624
Pubmed	The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.	FRAS1 FREM3 FREM2	8.00e-06	10	143	3	15345741
Pubmed	Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.	SIGLEC12 SIGLEC9 SIGLEC7	8.00e-06	10	143	3	25320078
Pubmed	Selective Response to Bacterial Infection by Regulating Siglec-E Expression.	SIGLEC12 SIGLEC9 SIGLEC7	1.10e-05	11	143	3	32889432
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	SIGLEC12 AMN CHODL SIGLEC9 GPAT3 ZCCHC2 LCLAT1 FGF17 CDH24 TREML4 AMIGO3 ELAPOR1 C1QTNF1 GPNMB ANKRD52	1.43e-05	985	143	15	12975309
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	PLOD3 ILF3 RAE1 POLRMT PCF11 AMOT NUFIP2 SMARCC2 MMS19 AQR	1.52e-05	440	143	10	34244565
Pubmed	The transcription factor XBP1 is selectively required for eosinophil differentiation.	SIGLEC12 SIGLEC9 SIGLEC7 IL5RA	1.63e-05	37	143	4	26147683
Pubmed	The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression.	SIGLEC9 SIGLEC7	1.68e-05	2	143	2	32322597
Pubmed	Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance.	SIGLEC9 SIGLEC7	1.68e-05	2	143	2	24569453
Pubmed	Identification of two novel CAKUT-causing genes by massively parallel exon resequencing of candidate genes in patients with unilateral renal agenesis.	FRAS1 FREM2	1.68e-05	2	143	2	21900877
Pubmed	NF90 interacts with components of RISC and modulates association of Ago2 with mRNA.	AGO2 ILF3	1.68e-05	2	143	2	36050755
Pubmed	Molecular study of 33 families with Fraser syndrome new data and mutation review.	FRAS1 FREM2	1.68e-05	2	143	2	18671281
Pubmed	Novel loss of function variants in FRAS1 AND FREM2 underlie renal agenesis in consanguineous families.	FRAS1 FREM2	1.68e-05	2	143	2	32643034
Pubmed	Depletion of Mab21l1 and Mab21l2 messages in mouse embryo arrests axial turning, and impairs notochord and neural tube differentiation.	MAB21L2 MAB21L1	1.68e-05	2	143	2	11857508
Pubmed	Targeting glycosylated antigens on cancer cells using siglec-7/9-based CAR T-cells.	SIGLEC9 SIGLEC7	1.68e-05	2	143	2	32391973
Pubmed	The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells.	SIGLEC9 SIGLEC7	1.68e-05	2	143	2	15557178
Pubmed	The Male Abnormal Gene Family 21 (Mab21) Members Regulate Eye Development.	MAB21L2 MAB21L1	1.68e-05	2	143	2	27558071
Pubmed	Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9.	SIGLEC9 SIGLEC7	1.68e-05	2	143	2	15292262
Pubmed	Genomic cloning and chromosomal localization of the mouse Mab21l2 locus.	MAB21L2 MAB21L1	1.68e-05	2	143	2	10516425
Pubmed	CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder.	SIGLEC12 SIGLEC9 SIGLEC7	1.89e-05	13	143	3	35921817
Pubmed	DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.	AGO2 ILF3 ZNF180 TNIP3 PHC2 NUFIP2 ELAPOR1 RNF10 MRTFA	2.12e-05	364	143	9	31391242
Pubmed	Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.	CERKL MYO7A PRPF8 CFB ALMS1	3.09e-05	87	143	5	20801516
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	RC3H2 AGO2 ILF3 RBBP6 POLRMT PRPF8 PES1 NUFIP2 UNK KYAT3 AQR NOL8 DUSP11	3.09e-05	807	143	13	22681889
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	ILF3 POLRMT PRPF8 NUFIP2	3.27e-05	44	143	4	26471122
Pubmed	Gli2 and Gli3 play distinct roles in the dorsoventral patterning of the mouse hindbrain.	IRX3 HOXD4 GLI3	3.66e-05	16	143	3	17026983
Pubmed	Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.	AGO2 TARBP2	5.02e-05	3	143	2	25446899
Pubmed	TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing.	AGO2 TARBP2	5.02e-05	3	143	2	15973356
Pubmed	Diversity of human copy number variation and multicopy genes.	TBC1D3E TBC1D3G	5.02e-05	3	143	2	21030649
Pubmed	Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors.	SIGLEC9 SIGLEC7	5.02e-05	3	143	2	16828866
Pubmed	A new granulation method for compressed tablets [proceedings].	AMOT TNFSF15	5.02e-05	3	143	2	12345
Pubmed	In vitro reconstitution of the human RISC-loading complex.	AGO2 TARBP2	5.02e-05	3	143	2	18178619
Pubmed	Human RISC couples microRNA biogenesis and posttranscriptional gene silencing.	AGO2 TARBP2	5.02e-05	3	143	2	16271387
Pubmed	Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins.	AGO2 AGO4	5.02e-05	3	143	2	19946268
Pubmed	Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9).	AGO2 TARBP2	5.02e-05	3	143	2	23361462
Pubmed	Structural insights into RNA processing by the human RISC-loading complex.	AGO2 TARBP2	5.02e-05	3	143	2	19820710
Pubmed	Mislocalization of DNAH5 and DNAH9 in respiratory cells from patients with primary ciliary dyskinesia.	DNAI1 DNAH9	5.02e-05	3	143	2	15750039
Pubmed	Presynaptic α2δ subunits are key organizers of glutamatergic synapses.	CACNA2D1 CACNA2D2	5.02e-05	3	143	2	33782113
Pubmed	Cut-like homeobox 1 and nuclear factor I/B mediate ENGRAILED2 autism spectrum disorder-associated haplotype function.	NFIB CUX1	5.02e-05	3	143	2	22180456
Pubmed	The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function.	CACNA2D1 CACNA2D2	5.02e-05	3	143	2	20080692
Pubmed	A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.	FRAS1 FREM3 FREM2	5.31e-05	18	143	3	14730302
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	FRAS1 PLOD3 ILF3 MYO7A NEB PHC2 SETBP1 TENM1 LRRC37B ALPK2	5.55e-05	513	143	10	25798074
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	FRAS1 AMN DNAI1 FREM2 LTBP1	6.03e-05	100	143	5	25807483
Pubmed	Requirement for Mab21l2 during development of murine retina and ventral body wall.	MAB21L2 DLX3 MAB21L1	6.28e-05	19	143	3	15385160
Pubmed	Molecular dissection of human Argonaute proteins by DNA shuffling.	AGO2 AGO4	1.00e-04	4	143	2	23748378
Pubmed	Role of alpha2/delta subunit in the development of morphine-induced rewarding effect and behavioral sensitization.	CACNA2D1 CACNA2D2	1.00e-04	4	143	2	19596051
Pubmed	The role of FREM2 and FRAS1 in the development of congenital diaphragmatic hernia.	FRAS1 FREM2	1.00e-04	4	143	2	29618029
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	1.73e-12	149	143	11	chr17q12
Cytoband	17q12	TBC1D3 TBC1D3H TBC1D3C TBC1D3B TBC1D3F	1.54e-05	99	143	5	17q12
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	SIGLEC12 MYOM1 LRIG2 PTPRF HMCN1 ALPK2	1.11e-04	161	85	6	593
GeneFamily	CD molecules\|C2-set domain containing\|Sialic acid binding Ig like lectins	SIGLEC12 SIGLEC9 SIGLEC7	3.02e-04	28	85	3	745
GeneFamily	Gelsolin/villins	CAPG VILL	6.00e-04	8	85	2	950
GeneFamily	Argonaute/PIWI family	AGO2 AGO4	6.00e-04	8	85	2	408
GeneFamily	1-acylglycerol-3-phosphate O-acyltransferases	GPAT3 LCLAT1	1.17e-03	11	85	2	46
GeneFamily	CD molecules\|Type II classical cadherins	CDH24 CDH20	1.65e-03	13	85	2	1186
GeneFamily	Dyneins, axonemal	DNAI1 DNAH9	2.84e-03	17	85	2	536
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRF PTPRN2	4.33e-03	21	85	2	813
CoexpressionAtlas	Mesoderm Day 15_vs_Mesoderm Day 30-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D POLRMT TBC1D3C TBC1D3B FREM2 TBC1D3G TBC1D3K TBC1D3F	2.14e-11	90	142	11	PCBC_ratio_MESO-15_vs_MESO-30_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-method_mRNA_vs_Endoderm Differentiated Cells-method_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D CAPG TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	1.75e-06	213	142	10	PCBC_ratio_DE_from-mRNA_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-reprogram_OSKM-L_vs_Endoderm Differentiated Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D CAPG TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	1.75e-06	213	142	10	PCBC_ratio_DE_from-OSKM-L_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	Ectoderm Differentiated Cells_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05	DMXL2 TBC1D3 TBC1D3H TBC1D3L PCDHGB7 TBC1D3D DOCK8 IRX3 MAB21L2 TBC1D3C TBC1D3B FREM2 FOXB1 CDH24 GLI3 LOXL2 SMARCC2 TBC1D3G NOTCH2 MRTFA TBC1D3K TBC1D3F	2.73e-06	1075	142	22	PCBC_ratio_ECTO_vs_DE_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-reprogram_OSKM-L_vs_Mesoderm Day 5-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B C1QTNF1 LTBP1 TBC1D3G TBC1D3K TBC1D3F	3.09e-06	281	142	11	PCBC_ratio_MESO-5_from-OSKM-L_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-method_mRNA_vs_Mesoderm Day 5-method_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B C1QTNF1 LTBP1 TBC1D3G TBC1D3K TBC1D3F	3.09e-06	281	142	11	PCBC_ratio_MESO-5_from-mRNA_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	DE cord blood_vs_DE blastocyst-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D CAPG TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	5.48e-06	242	142	10	PCBC_ratio_DE cord blood_vs_DE blastocyst_cfr-2X-p05
CoexpressionAtlas	Ectoderm Differentiated Cells_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05	DMXL2 TBC1D3 TBC1D3H TBC1D3L PCDHGB7 TBC1D3D DOCK8 VPS54 IRX3 TRIM68 MAB21L2 TBC1D3C TBC1D3B FOXB1 CDH24 AGO4 GLI3 LOXL2 SMARCC2 LTBP1 SLC26A11 TBC1D3G NOTCH2 TBC1D3K TBC1D3F	1.32e-05	1466	142	25	PCBC_ratio_ECTO_vs_SC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D IRX3 TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	6.03e-05	320	142	10	PCBC_ratio_MESO-5_vs_DE_cfr-2X-p05
CoexpressionAtlas	ratio_induced-Ectoderm_vs_StemCell_top-relative-expression-ranked_2500_k-means-cluster#3	DMXL2 TBC1D3 TBC1D3H MYO7A SIGLEC9 IRX3 MAB21L2 DNAI1 FOXB1 C6orf118 CDH20 GLI3 SETBP1 DLX3 ALPK2 TBC1D3F	1.80e-04	848	142	16	ratio_ECTO_vs_SC_2500_K3
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CERKL IRX3 ADGB DNAI1 C6orf118 PTPRF CFAP57 PZP DNAH9	1.33e-08	193	143	9	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL ADGB DNAI1 C6orf118 CFAP57 PZP DNAH9 IL5RA	2.82e-07	200	143	8	31d75c26055177d656df1fbb10b764cebd61e122
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CERKL ADGB DNAI1 C6orf118 VILL ELAPOR1 DNAH9 IL5RA	2.82e-07	200	143	8	da12821e8a0657869ca0f75d351cce2d7605a505
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL ADGB DNAI1 C6orf118 CFAP57 PZP DNAH9 IL5RA	2.82e-07	200	143	8	e1dce91c6c531bb212002a14705e496d77ad3490
ToppCell	LPS_IL1RA_TNF-Epithelial_airway\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CERKL ADGB DNAI1 C6orf118 VILL ELAPOR1 DNAH9 IL5RA	2.82e-07	200	143	8	72c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HNF1A ABAT AMN PDE7A MAP3K13 FGGY ALPK2	2.00e-06	181	143	7	9542c19edc9bd2cba68c01c2a8407705398e3011
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HNF1A ABAT AMN PDE7A MAP3K13 FGGY ALPK2	2.00e-06	181	143	7	8f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.00e-06	181	143	7	dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 NEB RYR2 FREM2 HMCN1 TENM1 DNAH9	2.23e-06	184	143	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 NEB RYR2 FREM2 HMCN1 TENM1 DNAH9	2.23e-06	184	143	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 NEB RYR2 FREM2 HMCN1 TENM1 DNAH9	2.23e-06	184	143	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.23e-06	184	143	7	5daff849625f2f41d56615569c0ed59cd733b34c
ToppCell	Ciliated_cells-B-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	ADGB DNAI1 CORO2B C6orf118 CFAP57 DNAH9 IL5RA	2.31e-06	185	143	7	4fc7113d3dadc716ec5a8e62b58543cc00ce5b16
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CERKL ADGB DNAI1 C6orf118 CFAP57 PZP DNAH9	2.31e-06	185	143	7	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	Adult-Epithelial-ciliated_cell-D175\|Adult / Lineage, Cell type, age group and donor	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.31e-06	185	143	7	30f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell	18-Distal-Epithelial-Multiciliated_precursor\|Distal / Age, Tissue, Lineage and Cell class	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.40e-06	186	143	7	58ab1360a1730655a5939295ba05997ac4a2d14e
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.49e-06	187	143	7	9e10ed56090d82589bc457788282f664b70ace4b
ToppCell	Epithelial-ciliated_cell\|World / Lineage, Cell type, age group and donor	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.57e-06	188	143	7	61a459f3fe57e5728efc72637ff2edc2d343492b
ToppCell	Adult-Epithelial-ciliated_cell-D231\|Adult / Lineage, Cell type, age group and donor	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.57e-06	188	143	7	34b11f72ca73153d02edcd09b38983ad1a504659
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.57e-06	188	143	7	2b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.67e-06	189	143	7	68a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCell	Adult-Epithelial-ciliated_cell\|Adult / Lineage, Cell type, age group and donor	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.67e-06	189	143	7	b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCell	COVID-19-lung-Ciliated\|lung / Disease (COVID-19 only), tissue and cell type	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.67e-06	189	143	7	27329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCell	BAL-Mild-Epithelial-Epithelial-Ciliated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IRX3 ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.86e-06	191	143	7	2a8e6d560907e71e9f6e190ca0667da804e25641
ToppCell	BAL-Mild-Epithelial-Epithelial-Ciliated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IRX3 ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.86e-06	191	143	7	46c9d4d10c66c0fae1fa351924091b69ea2f38d4
ToppCell	Mild_COVID-19-Epithelial-Ciliated\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	IRX3 ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.86e-06	191	143	7	995e76bbf07674d95b8ef09e078cf6410af27a09
ToppCell	BAL-Mild-Epithelial-Epithelial-Ciliated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IRX3 ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.86e-06	191	143	7	a37f20172b85566b9039254a89680e37fd503fd5
ToppCell	BAL-Mild-Epithelial-Epithelial-Ciliated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	IRX3 ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.86e-06	191	143	7	2d36e08c5629cf73b6dd02cd173cafb52e8a3a7d
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA2D1 FRAS1 LCLAT1 RYR2 HMCN1 GLI3 SETBP1	3.17e-06	194	143	7	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	FRAS1 PDE7A MYOM1 GPAT3 RYR2 LTBP1 ALPK2	3.17e-06	194	143	7	c3535f7cc0076653c72db582047cff053c322397
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	CACNA2D1 RYR2 HMCN1 NFIB GLI3 SETBP1 LTBP1	3.51e-06	197	143	7	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	CACNA2D1 RYR2 HMCN1 NFIB GLI3 SETBP1 LTBP1	3.75e-06	199	143	7	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	3.75e-06	199	143	7	2498237b9e895ca4826a3378d9d40989968df72b
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	3.75e-06	199	143	7	542ec45c931b40738df1f3777b00c83be33a514a
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	3.87e-06	200	143	7	96701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell	LPS_IL1RA-Epithelial_airway-airway_epithelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CERKL ADGB DNAI1 C6orf118 VILL ELAPOR1 DNAH9	3.87e-06	200	143	7	cf191104484bfb2b9f87de416b9453135f8833c1
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	3.87e-06	200	143	7	926a7ea94b5908aebf103893ea83ce9d25285b65
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL ADGB DNAI1 C6orf118 CFAP57 PZP DNAH9	3.87e-06	200	143	7	85c98da55f7cd4ffdf9d309b56c8cc5d43f3c04c
ToppCell	LPS_IL1RA-Epithelial_airway\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CERKL ADGB DNAI1 C6orf118 VILL ELAPOR1 DNAH9	3.87e-06	200	143	7	a5ae33dd4dc1ff6e1a1eec22c4d523d5ab657607
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL ADGB DNAI1 C6orf118 CFAP57 PZP DNAH9	3.87e-06	200	143	7	12bc7d95c4166d12487081a76d210b7abe5991b0
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	3.87e-06	200	143	7	06ce6e03498ba38ef6a06eaf2731e3b2eeda59eb
ToppCell	Ciliated_cells-A-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	CERKL ADGB C6orf118 CFAP57 DNAH9 SHISA6	1.46e-05	163	143	6	43194c6127df1ce3d29242f719645de3c11fd7c0
ToppCell	Ciliated_cells-B-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	CERKL DNAI1 C6orf118 CFAP57 PZP DNAH9	1.51e-05	164	143	6	0e9961acbb1d6c0089e6805ba6756736fa4d8bed
ToppCell	droplet-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l15\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYOM1 DOCK8 ZNF180 LIN54 TNIP3 AMOT	1.57e-05	165	143	6	1d0f60bf47a40ac916f0fcb5532a968742a0edbb
ToppCell	15-Distal-Epithelial-Multiciliated_precursor\|Distal / Age, Tissue, Lineage and Cell class	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9	1.68e-05	167	143	6	442ea71a581ed5a547a214132b9f1b0243fd0895
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADGB DNAI1 C6orf118 CFAP57 PZP DNAH9	1.79e-05	169	143	6	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-Deuterosomal\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	PPEF2 ADGB DNAI1 C6orf118 CFAP57 DNAH9	1.98e-05	172	143	6	08ad76412c9cc3504141797b44b88478ced87476
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA2D1 RYR2 HMCN1 SETBP1 C1QTNF1 LTBP1	2.05e-05	173	143	6	5416b092321c7d9b63f0418c60f2402a138355bf
ToppCell	PCW_10-12-Epithelial-Epithelial_ciliated\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9	2.11e-05	174	143	6	b8d1c556290d188f56aeefc17f03119686945fe7
ToppCell	PCW_10-12-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9	2.11e-05	174	143	6	00cf27bc23af1472a507be31fba6245a8fdd901b
ToppCell	PCW_13-14-Epithelial-Epithelial_ciliated\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9	2.18e-05	175	143	6	b1369d2b74f461e6822d0c33e9b50fe0dfbceb54
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 RYR2 FAH HMCN1 DNAH9 IL5RA	2.18e-05	175	143	6	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	PCW_13-14-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9	2.18e-05	175	143	6	c82ec6deb6ccdd991a69a62b6d62d5b14c803d7a
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 RYR2 FAH HMCN1 DNAH9 IL5RA	2.26e-05	176	143	6	c6484334187f64cd00cd35e77d8ae436556b4260
ToppCell	343B-Fibroblasts-Fibroblast-B_(Myofibroblast)\|343B / Donor, Lineage, Cell class and subclass (all cells)	CACNA2D1 MYOM1 PCDHGB7 RYR2 HMCN1 LTBP1	2.33e-05	177	143	6	e55d21d4d61a069b9bbe0e7595fbfb7cfbacfd87
ToppCell	343B-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	CACNA2D1 MYOM1 PCDHGB7 RYR2 HMCN1 LTBP1	2.33e-05	177	143	6	43ba6f12c2fb32698a420bf799d46ac1b558f146
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CERKL ADGB DNAI1 C6orf118 DNAH9 IL5RA	2.40e-05	178	143	6	de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP32 TEK CORO2B CASKIN2 C1QTNF1 MMS19	2.48e-05	179	143	6	025d414ec88d5680d99c8173e70ee3bb0b694f74
ToppCell	Ciliated_cells-A-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ADGB DNAI1 C6orf118 CFAP57 PZP DNAH9	2.48e-05	179	143	6	0e6c22de2e3fb0ff23b3301863cf4011c5c59dff
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HNF1A ABAT AMN MAP3K13 FGGY ALPK2	2.48e-05	179	143	6	d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-Ciliated\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9	2.64e-05	181	143	6	8eed9d46d924b16f6dd1a025ff612244b02b4391
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-4\|TCGA-Endometrium / Sample_Type by Project: Shred V9	ADGB DNAI1 C6orf118 CFAP57 DNAH9 IL5RA	2.64e-05	181	143	6	51d91b923920463245e95d65c6a5197e21d34d73
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CERKL POLRMT DNAI1 HMCN1 HOXD4 PRMT9	2.81e-05	183	143	6	919c9861073d12fd12aecd7469b1478b13838c43
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABAT AMN ACOT4 CFB FAH FGGY	2.90e-05	184	143	6	3d7dd193a0826cc7a4e454a29236a16c315e5965
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABAT AMN ACOT4 CFB FAH FGGY	2.90e-05	184	143	6	45577ff91c3b2b303acd97239dde2463ea7a429c
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CERKL ADGB DNAI1 C6orf118 DNAH9 IL5RA	2.98e-05	185	143	6	3e39a3cb534dfe2301930f3e2f7e8cefb522c158
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ILF3 POLRMT ELAPOR1 KYAT3 MAPK6 TARBP2	2.98e-05	185	143	6	7925519b855f76444a0b57382ce35d89457b0b14
ToppCell	COVID-19-Epithelial_cells-Airway_ciliated\|COVID-19 / group, cell type (main and fine annotations)	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9	2.98e-05	185	143	6	18a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell	NS-critical-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9	3.08e-05	186	143	6	76033438426d8f9c72cd6691a7baf92104c9f03d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK8 NFIB MAP3K13 FGGY CUX1 ALPK2	3.08e-05	186	143	6	f28d72b47624b69a580b4429e2be560a26898591
ToppCell	Ciliated_cells-B-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ADGB DNAI1 C6orf118 CFAP57 PZP DNAH9	3.17e-05	187	143	6	2b4262c2e7c7830a976be168cee6eeb738d4feda
ToppCell	390C-Epithelial_cells-Epithelial-F_(Ciliated)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ADGB DNAI1 C6orf118 CFAP57 PZP DNAH9	3.17e-05	187	143	6	88f785932e67c613db0dda84496de351359ed962
ToppCell	390C-Epithelial_cells-Epithelial-F_(Ciliated)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ADGB DNAI1 C6orf118 CFAP57 PZP DNAH9	3.17e-05	187	143	6	8896a00b30d11b90ca42726d4e122174a30b161b
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	MYOM1 GPAT3 NEB RYR2 LTBP1 ALPK2	3.27e-05	188	143	6	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABAT AMN MAP3K13 FGGY CUX1 ALPK2	3.27e-05	188	143	6	f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCell	COVID-19-lung-Ciliated\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CERKL ADGB DNAI1 C6orf118 DNAH9 IL5RA	3.36e-05	189	143	6	a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	AMN NFIB TENM1 MAP3K13 FGGY ALPK2	3.36e-05	189	143	6	204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	AMN NFIB TENM1 MAP3K13 FGGY ALPK2	3.36e-05	189	143	6	13fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9	3.36e-05	189	143	6	a3cd4c2da4feb9bdcd8957f3e344d095da1367b8
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9	3.36e-05	189	143	6	93b1026bb1ba759e5704561c9a5de14a30c08894
ToppCell	cellseq2-Epithelial-Epithelial_Airway\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9	3.46e-05	190	143	6	17829f4de31b3d9e4d71ba4817d18842aa699773
ToppCell	BAL-Control-Epithelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IRX3 DNAI1 C6orf118 PTPRF NFIB DNAH9	3.57e-05	191	143	6	9f19098f260d5542aa8ba7eb6f91b44d0db6e0a4
ToppCell	Control-Epithelial-Ciliated_cells\|Control / Condition, Lineage and Cell class	IRX3 DNAI1 C6orf118 PTPRF CFAP57 DNAH9	3.57e-05	191	143	6	ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCell	BAL-Control-Epithelial\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IRX3 DNAI1 C6orf118 PTPRF NFIB DNAH9	3.57e-05	191	143	6	5129f778a9283bfac4ff322c21c5ca71da4b7174
ToppCell	BAL-Control-Epithelial-Epithelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IRX3 DNAI1 C6orf118 PTPRF NFIB DNAH9	3.57e-05	191	143	6	df8a1a6e78aa0cb941b94cb676bd6891d79f3687
ToppCell	Control-Epithelial\|Control / Disease group,lineage and cell class （2021.01.30）	IRX3 DNAI1 C6orf118 PTPRF NFIB DNAH9	3.57e-05	191	143	6	b78547dae8328244a47c83346447bdd787efbcae
ToppCell	BAL-Control-Epithelial-Epithelial\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IRX3 DNAI1 C6orf118 PTPRF NFIB DNAH9	3.57e-05	191	143	6	c50d6a1a6209ed4157f7c00fc24d4ecb43790f44
ToppCell	Control-Epithelial\|Control / Condition, Lineage and Cell class	IRX3 DNAI1 C6orf118 PTPRF CFAP57 DNAH9	3.57e-05	191	143	6	6228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFB NFIB LOXL2 C1QTNF1 LTBP1 GPNMB	3.67e-05	192	143	6	fc940f91ff8e051631dbf25e6e8d73cf8337eccb
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFB NFIB LOXL2 C1QTNF1 LTBP1 GPNMB	3.67e-05	192	143	6	7a2e79490e4f7058bb76b46c45b5df9f729e3146
ToppCell	facs-Trachea-24m-Mesenchymal\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFB NFIB LOXL2 C1QTNF1 LTBP1 GPNMB	3.67e-05	192	143	6	e8af6ad1ae99cae13a82d0d8d7f38af9b777f0ba
ToppCell	COVID-19-Fibroblasts-Other_FB\|COVID-19 / group, cell type (main and fine annotations)	CACNA2D1 RYR2 HMCN1 GLI3 SETBP1 LTBP1	3.78e-05	193	143	6	e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCell	NS-critical-d_07-13-Epithelial-Secretory\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	AMN CFB FER1L6 FREM2 NFIB ELAPOR1	3.89e-05	194	143	6	2172d951896265243d14996eacce5aab5e14e26e
ToppCell	NS-critical-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9	3.89e-05	194	143	6	1ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell	RA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	FRAS1 MYOM1 GPAT3 RYR2 LTBP1 ALPK2	3.89e-05	194	143	6	89812fb164065041357bb37a3c2d87028ec3de4e
ToppCell	COVID-19-Epithelial-Ciliated_cells\|COVID-19 / Condition, Lineage and Cell class	IRX3 ADGB DNAI1 C6orf118 CFAP57 DNAH9	3.89e-05	194	143	6	43be5fbd51dd58839cb03ca3ddd05a458e1ddb74
ToppCell	Differ-Basal\|World / shred by cell class for mouse tongue	ABAT DOCK8 DNAI1 SETBP1 C1QTNF1 NOTCH2	3.89e-05	194	143	6	851eff82c9f3d44c86e3e127a804bbd1fced6a7c
ToppCell	Children_(3_yrs)-Mesenchymal\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA2D1 RYR2 HMCN1 NFIB SETBP1 LTBP1	4.12e-05	196	143	6	bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CERKL ADGB DNAI1 C6orf118 CFAP57 DNAH9	4.24e-05	197	143	6	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	CACNA2D1 RYR2 HMCN1 GLI3 SETBP1 LTBP1	4.24e-05	197	143	6	f1c8936986123a3151140c374fcd62d6705c530b
Drug	chlorpromazine hydrochloride; Up 200; 1uM; HL60; HT_HG-U133A	ARHGAP32 DMXL2 NEB SIGLEC7 NFIB REPS2 FGGY NOTCH2 MRTFA	2.82e-06	196	136	9	1158_UP
Disease	sialic acid-binding Ig-like lectin 9 measurement	SIGLEC12 SIGLEC9 SIGLEC7	7.71e-06	9	135	3	EFO_0008286
Disease	Headache	CACNA2D1 ZCCHC2 NFIB NUFIP2 CUX1	1.14e-05	64	135	5	HP_0002315
Disease	West syndrome (implicated_via_orthology)	ABAT GUF1	2.08e-05	2	135	2	DOID:0050562 (implicated_via_orthology)
Disease	Cryptophthalmos syndrome	FRAS1 FREM2	6.21e-05	3	135	2	C0265233
Disease	FRASER SYNDROME 1	FRAS1 FREM2	6.21e-05	3	135	2	C4551480
Disease	Fraser syndrome (implicated_via_orthology)	FRAS1 FREM2	1.24e-04	4	135	2	DOID:0090001 (implicated_via_orthology)
Disease	amino acid measurement	CACNA2D1 ABAT GLS2 RYR2 PHC2 C6orf118 ALMS1 PTPRN2 LTBP1 MAPK6 MRTFA	2.97e-04	678	135	11	EFO_0005134
Disease	Global developmental delay	ABAT CACNA2D2 NFIB SMARCC2 MAB21L1	3.74e-04	133	135	5	C0557874
Disease	Malignant neoplasm of breast	TRAPPC8 TEK CDH20 LOXL2 SETBP1 ELAPOR1 TENM1 MAP3K13 GPNMB REPS2 DNAH9 CUX1 NOTCH2 PGBD3	4.21e-04	1074	135	14	C0006142
Disease	Glycosuria	CERKL HNF1A	4.30e-04	7	135	2	HP_0003076
Disease	Akinetic Petit Mal	CACNA2D2 JRK	4.30e-04	7	135	2	C0001890
Disease	Epilepsy, Absence, Atypical	CACNA2D2 JRK	4.30e-04	7	135	2	C0751124
Disease	Absence Seizure Disorder	CACNA2D2 JRK	4.30e-04	7	135	2	C4553705
Disease	Juvenile Absence Epilepsy	CACNA2D2 JRK	4.30e-04	7	135	2	C4317339
Disease	Childhood Absence Epilepsy	CACNA2D2 JRK	4.30e-04	7	135	2	C4281785
Disease	Epilepsy, Minor	CACNA2D2 JRK	4.30e-04	7	135	2	C4552765
Disease	Absence Epilepsy	CACNA2D2 JRK	4.30e-04	7	135	2	C0014553
Disease	Disorder of eye	CERKL FRAS1 MYO7A PRPF8 FREM2 ALMS1	4.46e-04	212	135	6	C0015397
Disease	Unilateral agenesis of kidney	FRAS1 FREM2	5.71e-04	8	135	2	C0266294
Disease	creatinine measurement	HNF1A PDE7A NEB PHC2 CDH20 ALMS1 SETBP1 KYAT3 CFAP57 REPS2 CUX1 MRTFA DUSP11	6.66e-04	995	135	13	EFO_0004518
Disease	sialic acid-binding ig-like lectin 7 measurement	SIGLEC9 SIGLEC7	7.32e-04	9	135	2	EFO_0020739
Disease	cognitive function measurement	SEMA4D DMXL2 AGO2 CACNA2D2 ZCCHC2 C6orf118 ALMS1 PTPRF PTPRN2 NFIB GLI3 SETBP1 RNF10 LTBP1 ATIC MRTFA	8.82e-04	1434	135	16	EFO_0008354
Disease	cerebrospinal fluid biomarker measurement	SIGLEC9 PPEF2 SIGLEC7 GPNMB	1.01e-03	96	135	4	EFO_0006794
Disease	glutamine measurement, amino acid measurement	GLS2 MIPEP	1.11e-03	11	135	2	EFO_0005134, EFO_0009768
Disease	N-acetylphenylalanine measurement	ALMS1 DUSP11	1.11e-03	11	135	2	EFO_0800019
Disease	blood urea nitrogen measurement	HNF1A PDE7A PHC2 CDH20 JRK SETBP1 MIPEP KYAT3	1.16e-03	452	135	8	EFO_0004741
Disease	cognitive function measurement, self reported educational attainment	DMXL2 AGO2 CACNA2D2 ALMS1 PTPRF PTPRN2 MRTFA	1.28e-03	355	135	7	EFO_0004784, EFO_0008354
Disease	C-reactive protein measurement	SEMA4D HNF1A DMXL2 GLS2 SIGLEC9 ZCCHC2 PTPRF NFIB NUFIP2 RNF10 SMARCC2 C1QTNF1 MAPK6 CUX1	1.29e-03	1206	135	14	EFO_0004458
Disease	generalised epilepsy	GLS2 CACNA2D2 RYR2	1.76e-03	52	135	3	EFO_0005917
Disease	cardiotoxicity, response to anthracycline-based chemotherapy	ILF3 POLRMT	1.82e-03	14	135	2	EFO_0005257, EFO_1001482
Disease	C-X-C motif chemokine 11 measurement	PPEF2 CUX1	1.82e-03	14	135	2	EFO_0008057
Disease	rostral middle frontal gyrus volume measurement	ADGB MAPK6	1.82e-03	14	135	2	EFO_0010328
Disease	Polydactyly	FRAS1 FREM2 ALMS1 GLI3	2.08e-03	117	135	4	C0152427
Disease	myeloid cell surface antigen CD33 measurement	SIGLEC12 SIGLEC7	2.10e-03	15	135	2	EFO_0008238
Disease	1,3,7-trimethylurate measurement	FRAS1 PTPRF	2.10e-03	15	135	2	EFO_0021172
Disease	isoleucine measurement	GLS2 MIPEP CFAP57	2.17e-03	56	135	3	EFO_0009793
Disease	developmental dysplasia of the hip	ABAT SHISA6	2.39e-03	16	135	2	EFO_1000648
Disease	creatine kinase measurement	NEB GPNMB MRTFA	2.53e-03	59	135	3	EFO_0004534
Disease	Age-related macular degeneration	CFB HMCN1	3.03e-03	18	135	2	cv:C0242383
Disease	parahippocampal gyrus volume measurement	CHODL FREM2	3.03e-03	18	135	2	EFO_0010318
Disease	Myeloid Leukemia	AGO2 SETBP1	3.03e-03	18	135	2	C0023470
Disease	Leukemia, Monocytic, Chronic	AGO2 SETBP1	3.03e-03	18	135	2	C0023466
Disease	Cannabis use, age at onset	RYR2 CDH20	3.38e-03	19	135	2	EFO_0004847, EFO_0007585
Disease	macrophage inflammatory protein 1b measurement	TBC1D3 CACNA2D2 TBC1D3B TBC1D3F	3.59e-03	136	135	4	EFO_0008219
Disease	CCL4 measurement	TBC1D3 TBC1D3F	3.74e-03	20	135	2	EFO_0004751
Disease	Ischemic stroke	ILF3 PRPF8 TEK SETBP1 PRMT9 SLC26A11	3.85e-03	324	135	6	HP_0002140
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	PDE7A RYR2 PHC2 ALMS1 PTPRF PTPRN2 NFIB SETBP1 NUFIP2 CUX1	3.86e-03	801	135	10	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	serum metabolite measurement	CACNA2D1 HNF1A GLS2 RAE1 TEK OR10AG1 ALMS1 PTPRN2 MIPEP KYAT3 SHISA6	4.19e-03	945	135	11	EFO_0005653
Disease	stroke	ILF3 PRPF8 PTPRF SHISA6	4.39e-03	144	135	4	EFO_0000712
Disease	gamma-glutamylglutamine measurement	GLS2 MIPEP	4.52e-03	22	135	2	EFO_0021138

Protein segments in the cluster

Peptide	Gene	Start	Entry
HQQVYAPLRADGDKP	TNFSF15	81	O95150
EFYKAQGPLPNQHSL	AMOT	216	Q4VCS5
GIHLPTNVKFQSPAY	PRMT9	326	Q6P2P2
GYVLLHPNLKPQTTN	CACNA2D2	556	Q9NY47
ISTVHPQQEDPNKPY	ADGB	1346	Q8N7X0
AHIYPGDSAVANKQP	ALPK2	281	Q86TB3
EYSQGASPQPQHQLK	CUX1	1231	P39880
KHKEYNPIENSPGNV	GPNMB	521	Q14956
EKPGIFYQQTLPGSH	ALMS1	1196	Q8TCU4
QVRDYPKHNGQISDP	ALMS1	3566	Q8TCU4
LPQYHGLQVAVSKVP	AMN	281	Q9BXJ7
YKNLGNLPHVQLLPE	AQR	1151	O60306
HGATVLQYAPKQQLL	DMXL2	2901	Q8TDJ6
GNVAIYNLKKPHSQP	DNAI1	406	Q9UI46
PCLQVGQEQKHTYLP	AGO4	316	Q9HCK5
LPAFLKNGLYLHNNP	AMIGO3	206	Q86WK7
NQPNDKGFTPLHVAA	ANKRD52	266	Q8NB46
SGPYQAQPNAILEKV	CERS5	81	Q8N5B7
KLYKNGEVPLEHSPN	DLX3	186	O60479
PCLQVGQEQKHTYLP	AGO2	326	Q9UKV8
KRLYQGQLPFPNHAE	FGF17	176	O60258
AIHYINPPNPAKDNF	RAE1	241	P78406
FIQNYSRKGHETPQP	RC3H2	391	Q9HBD1
KAPVGHLYQTQAPSA	PZP	1196	P20742
PHLNPQDTLKNYVPS	NFIB	391	O00712
GVLNPNEQPTHKLYA	GUF1	301	Q8N442
TYSKDLLGQQPHSEP	PTPRN2	451	Q92932
AYLVHVPENNQPGAS	PCDHGB7	456	Q9Y5F8
HPNYNINGKKEAGIP	CFB	556	P00751
VVHGNGPTKLQLNYL	PLOD3	251	O60568
QRDKQPNAQPQYLHG	CYFIP1	876	Q7L576
PNAQPQYLHGSKALN	CYFIP1	881	Q7L576
QDGQVAQTILPAYHP	NOTCH2	2361	Q04721
GTITYLQPKPHQFQR	OR10AG1	246	Q8NH19
NEGPQYGCIQPNKHL	FRAS1	3741	Q86XX4
KGQPHPLCSNLQNYS	GLI3	1426	P10071
PNVQQIQVPGSKFHY	LIN54	346	Q6MZP7
LVQGFHAAPQDVKPN	MMS19	876	Q96T76
PLQKEFNEYQAHAGP	CFAP57	626	Q96MR6
QARGFYPQSHQEPVK	ATXN1L	391	P0C7T5
ILKAHQPYGVQACVP	ELAPOR1	626	Q6UXG2
QAQINHHKIAYRPPG	FREM2	776	Q5SZK8
GYSHPALLKLIQQPQ	ABAT	106	P80404
YPHNIPQSEKHLLQG	LCLAT1	261	Q6UWP7
APEYHQPQAPANVAK	LOXL2	41	Q9Y4K0
QAAYHLTVPENKAPG	CDH24	376	Q86UP0
GIQHLPVAYKAQGNA	JRK	246	O75564
QIPVHGASVPKLYQH	LTBP1	431	Q14766
GASVPKLYQHSQQPG	LTBP1	436	Q14766
NKQLESIGIPQFHSP	MAPK6	671	Q16659
HPGVNQPFLIKTNHY	PDE7A	256	Q13946
KPEVAQYTHTGLLPQ	HNF1A	506	P20823
VQPPGEDQAHYNLPK	LRRC37B	326	Q96QE4
YNKLSLNEEGIPHNP	GLS2	251	Q9UI32
QHAKKANGPNYIQPQ	NOL8	631	Q76FK4
QPHQAYLSGDPEKAR	ARHGAP32	1151	A7KAX9
DPNYTTPLHLAAKNG	CASKIN2	186	Q8WXE0
EHSNKLGYLVSPPQQ	RBBP6	506	Q7Z6E9
HLAPSKPADAAQYLQ	FOXB1	116	Q99853
VDNKHYNLQVFAPPN	HMCN1	3421	Q96RW7
HVNSVNPNYTGGEPK	HOXD4	141	P09016
PKAYPDNHLSQVDVN	PCF11	1256	O94913
LKNQPAQENSPHPTY	MAP3K13	606	O43283
LALRYHPDKNPGNAQ	DNAJC5G	56	Q8N7S2
QRGPPLYTKHNPQEQ	CEFIP	406	Q711Q0
PVHQYQPGDHVLIKS	ZNF561-AS1	71	K7EIQ3
SQPIYVGNDEHKPLR	IL5RA	326	Q01344
ERNSYPQKVQGGHSP	BCLAF3	126	A2AJT9
QVKANYFPSPGITLH	BCLAF3	481	A2AJT9
QHEKYRPSQDQGLPA	C1QTNF1	56	Q9BXJ1
IEPNYPKVCGHQGNV	CORO2B	76	Q9UQ03
KQFTLPPNLGQYHRQ	DOCK8	26	Q8NF50
HNKPVKQGPRYNLHQ	DUSP11	276	O75319
IHPVAIKYNPQFGDA	GPAT3	326	Q53EU6
DPNGYVLLHPNLQPK	CACNA2D1	516	P54289
VADNYSKIGNQVLPP	FGGY	216	Q96C11
DVNDNPPRFPQKHYQ	CDH20	266	Q9HBT6
LQYKLVSQTGPVHAP	ILF3	416	Q12906
SGHLNPNKLYQPPET	C6orf118	61	Q5T5N4
KVHPRNNTGGYNPEE	CERKL	496	Q49MI3
HLELPGQPLNNYHMK	MAB21L2	261	Q9Y586
KALNGAEPNYHSLPS	LAMTOR1	31	Q6IAA8
QYAPNTQVEILPQGH	CAPG	321	P40121
TGPVLSKHQDVFNQP	FAH	51	P16930
KLANPHYQPELQAQA	DNAH9	3556	Q9NYC9
REGGQYKLIPHNPNA	RYR2	4386	Q92736
QQIGILKPHPAYVQL	POLRMT	616	O00411
IILNTPHNPLGKVYN	KYAT3	211	Q6YP21
PHNPLGKVYNREELQ	KYAT3	216	Q6YP21
GPALTPHIVQYQANK	PPEF2	526	O14830
YAHIQKLGQVPPGES	PTPRF	1621	P10586
AQYELKDSPGVQHPA	IRX3	91	P78415
QPYQGKNPNTKHEEY	PGBD3	311	Q8N328
KIAYQPPAENSHGER	FREM3	386	P0C091
NQHKVAYQPPQKLGI	FREM3	781	P0C091
HPEKPLVTEGNRNYN	FER1L6	556	Q2WGJ9
QQNGYHGRPNKPVDT	PGGT1B	256	P53609
SQKAPLLFHQQPLEG	RHNO1	11	Q9BSD3
YGGDPQNPHKLHIVT	MRPL30	56	Q8TCC3
HLELPGQPLNNYHMK	MAB21L1	261	Q13394
KYPPQEAEQLSHQAA	RECQL4	876	O94761
QYAPLSFHKGEPQDL	SIGLEC7	436	Q9Y286
KTVHLNVSYPPQNLT	SIGLEC9	226	Q9Y336
QNLAHLPPSYESAVK	SHISA6	291	Q6ZSJ9
LPPIISKDGNYSVHQ	TEX49	36	A0A1B0GTD5
NGPAHNNKLFAPVAL	TENM1	1186	Q9UKZ4
QQNGEHPKPALDTGY	SEMA4D	801	Q92854
PKPFRSYNNNVDHLG	TBC1D3L	36	B9A6J9
HKARPQYPQEQEAIG	SIGLEC12	571	Q96PQ1
KNNASHVVYPVPGNL	SMARCC2	171	Q8TAQ2
QHHNYQAILPAPPKS	MRTFA	281	Q969V6
HTPKAQSQPQLYQTD	SLFNL1	326	Q499Z3
GNTAINYKHSSIPPL	ACOT4	261	Q8N9L9
EKPYLTNQPGDTHQN	CHODL	191	Q9H9P2
GNLLEDPLNSPKYQH	ZCCHC2	701	Q9C0B9
NTDKGNNPKGYLPSH	PRPF8	2241	Q6P2Q9
PKPFRSYNNNVDHLG	TBC1D3B	36	A6NDS4
PKPFRSYNNNVDHLG	TBC1D3H	36	P0C7X1
YAQGFLPEKLPQQDH	PHC2	601	Q8IXK0
HYGDTNQKLPDNPER	TRIM68	326	Q6AZZ1
HPGQTLLLQCQYSPK	TREML4	31	Q6UXN2
YALDQLPPDVQHKAN	TNIP3	301	Q96KP6
NQFARHYQTGQPLPK	MIPEP	541	Q99797
QYLQHGAEGSPKAQP	NUFIP2	56	Q7Z417
LLNLHYPPKLEGQAQ	PES1	241	O00541
GNPAELHGTKVQIPY	REPS2	151	Q8NFH8
PKPFRSYNNNVDHLG	TBC1D3F	36	A6NER0
AEKHLRQEPGTQPYN	SLC26A11	576	Q86WA9
QGKYPEVHIPLENLQ	RNF10	626	Q8N5U6
GKDINPHIPQYISSV	SLU7	56	O95391
PKPFRSYNNNVDHLG	TBC1D3E	36	A0A087X179
KPLNAPNVIDTGHNF	TEK	446	Q02763
NPHQTPAQLYTLQPK	ATIC	211	P31939
PIHPTKYTNNLQGDE	TOP3A	416	Q13472
YVILHVPQSPKATQG	VILL	41	O15195
YENNECGKPPQSIHL	ZNF180	246	Q9UJW8
VNKGVIPSNFHPTQY	TRAPPC8	721	Q9Y2L5
PKPFRSYNNNVDHLG	TBC1D3D	36	A0A087WVF3
PVYDLLKAEGQAHQP	TARBP2	46	Q15633
AQVLQAQPEKPQHYT	UNK	21	Q9C0B0
GFQPQAYERPQKHST	SETBP1	176	Q9Y6X0
PKPFRSYNNNVDHLG	TBC1D3G	36	Q6DHY5
PKPFRSYNNNVDHLG	TBC1D3	36	Q8IZP1
PKPFRSYNNNVDHLG	TBC1D3K	36	A0A087X1G2
PKPFRSYNNNVDHLG	TBC1D3I	36	A0A087WXS9
PKPFRSYNNNVDHLG	TBC1D3C	36	Q6IPX1
VYHSKVNLPAALNDP	VPS54	66	Q9P1Q0
SHQQLMPPANGYIHK	LRIG2	876	O94898
ANYIPPKNNHETQFG	MYO7A	536	Q13402
YKNQVPINVHANPGK	MYOM1	311	P52179
PINVHANPGKYIIES	MYOM1	316	P52179
HKYNLPPDLPQFIQA	NEB	1026	P20929