Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE4A PDE4B PDE4C PDE4D	3.63e-07	22	55	4	GO:0004115
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE4A PDE4B PDE4C PDE4D	5.25e-07	24	55	4	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE4A PDE4B PDE4C PDE4D	6.24e-07	25	55	4	GO:0004114
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE4A PDE4B PDE4C PDE4D	8.62e-07	27	55	4	GO:0004112
GeneOntologyMolecularFunction	cAMP binding	PDE4A PDE4B PDE4D	4.36e-05	25	55	3	GO:0030552
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	PDE4A PDE4B PDE4C PDE4D	1.48e-04	97	55	4	GO:0008081
GeneOntologyMolecularFunction	cyclic nucleotide binding	PDE4A PDE4B PDE4D	1.68e-04	39	55	3	GO:0030551
GeneOntologyMolecularFunction	coreceptor activity	NGFR ACVR2A IL1RAP	1.03e-03	72	55	3	GO:0015026
GeneOntologyMolecularFunction	transmembrane receptor protein serine/threonine kinase activity	AMHR2 ACVR2A	1.37e-03	20	55	2	GO:0004675
GeneOntologyMolecularFunction	AMP binding	PRKAG3 PFKM	1.51e-03	21	55	2	GO:0016208
GeneOntologyBiologicalProcess	cAMP catabolic process	PDE4A PDE4B PDE4C PDE4D	5.23e-09	9	54	4	GO:0006198
GeneOntologyBiologicalProcess	cyclic nucleotide catabolic process	PDE4A PDE4B PDE4C PDE4D	4.12e-08	14	54	4	GO:0009214
GeneOntologyBiologicalProcess	cAMP metabolic process	PDE4A PDE4B PDE4C PDE4D	5.09e-07	25	54	4	GO:0046058
GeneOntologyBiologicalProcess	purine ribonucleotide catabolic process	PRKAG3 PDE4A PDE4B PDE4C PDE4D PFKM	5.16e-06	169	54	6	GO:0009154
GeneOntologyBiologicalProcess	cyclic purine nucleotide metabolic process	PDE4A PDE4B PDE4C PDE4D	5.27e-06	44	54	4	GO:0052652
GeneOntologyBiologicalProcess	cyclic nucleotide metabolic process	PDE4A PDE4B PDE4C PDE4D	5.77e-06	45	54	4	GO:0009187
GeneOntologyBiologicalProcess	negative regulation of relaxation of cardiac muscle	PDE4B PDE4D	6.73e-06	2	54	2	GO:1901898
GeneOntologyBiologicalProcess	ribonucleotide catabolic process	PRKAG3 PDE4A PDE4B PDE4C PDE4D PFKM	6.95e-06	178	54	6	GO:0009261
GeneOntologyBiologicalProcess	purine nucleotide catabolic process	PRKAG3 PDE4A PDE4B PDE4C PDE4D PFKM	7.90e-06	182	54	6	GO:0006195
GeneOntologyBiologicalProcess	purine-containing compound catabolic process	PRKAG3 PDE4A PDE4B PDE4C PDE4D PFKM	9.51e-06	188	54	6	GO:0072523
GeneOntologyBiologicalProcess	nucleotide catabolic process	PRKAG3 PDE4A PDE4B PDE4C PDE4D PFKM	1.69e-05	208	54	6	GO:0009166
GeneOntologyBiologicalProcess	nucleoside phosphate catabolic process	PRKAG3 PDE4A PDE4B PDE4C PDE4D PFKM	2.09e-05	216	54	6	GO:1901292
GeneOntologyBiologicalProcess	regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	PDE4A PDE4B PDE4D	4.23e-05	26	54	3	GO:0106070
GeneOntologyBiologicalProcess	cAMP-mediated signaling	PDE4A PDE4B PDE4C PDE4D	4.68e-05	76	54	4	GO:0019933
GeneOntologyBiologicalProcess	nucleobase-containing compound catabolic process	PRKAG3 NBAS PDE4A PDE4B PDE4C PDE4D GIGYF2 ZCCHC7 PFKM	7.35e-05	696	54	9	GO:0034655
GeneOntologyBiologicalProcess	organophosphate catabolic process	PRKAG3 PDE4A PDE4B PDE4C PDE4D PFKM	9.04e-05	281	54	6	GO:0046434
GeneOntologyBiologicalProcess	negative regulation of relaxation of muscle	PDE4B PDE4D	1.40e-04	7	54	2	GO:1901078
GeneOntologyBiologicalProcess	carbohydrate derivative catabolic process	PRKAG3 PDE4A PDE4B PDE4C PDE4D PFKM	1.93e-04	323	54	6	GO:1901136
GeneOntologyBiologicalProcess	regulation of relaxation of cardiac muscle	PDE4B PDE4D	2.39e-04	9	54	2	GO:1901897
GeneOntologyBiologicalProcess	positive regulation of interleukin-5 production	PDE4D IL1RAP	5.15e-04	13	54	2	GO:0032754
GeneOntologyBiologicalProcess	cellular response to epinephrine stimulus	PDE4B PDE4D	6.00e-04	14	54	2	GO:0071872
Domain	PDEase	PDE4A PDE4B PDE4C PDE4D	2.34e-07	19	54	4	IPR023088
Domain	PDEase_I	PDE4A PDE4B PDE4C PDE4D	3.60e-07	21	54	4	PF00233
Domain	PDEASE_I	PDE4A PDE4B PDE4C PDE4D	3.60e-07	21	54	4	PS00126
Domain	PDEase_CS	PDE4A PDE4B PDE4C PDE4D	3.60e-07	21	54	4	IPR023174
Domain	-	PDE4A PDE4B PDE4C PDE4D	4.39e-07	22	54	4	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE4A PDE4B PDE4C PDE4D	5.30e-07	23	54	4	IPR002073
Domain	HDc	PDE4A PDE4B PDE4C PDE4D	6.35e-07	24	54	4	SM00471
Domain	HD/PDEase_dom	PDE4A PDE4B PDE4C PDE4D	6.35e-07	24	54	4	IPR003607
Domain	-	RGPD4 SPTBN5 RASGRF1 OSBPL5 OSBPL6 PLEKHG5 FERMT3	1.27e-04	391	54	7	2.30.29.30
Domain	PH	SPTBN5 RASGRF1 OSBPL5 OSBPL6 PLEKHG5 FERMT3	1.46e-04	278	54	6	SM00233
Domain	PH_DOMAIN	SPTBN5 RASGRF1 OSBPL5 OSBPL6 PLEKHG5 FERMT3	1.49e-04	279	54	6	PS50003
Domain	PH_domain	SPTBN5 RASGRF1 OSBPL5 OSBPL6 PLEKHG5 FERMT3	1.52e-04	280	54	6	IPR001849
Domain	PH_dom-like	RGPD4 SPTBN5 RASGRF1 OSBPL5 OSBPL6 PLEKHG5 FERMT3	2.15e-04	426	54	7	IPR011993
Domain	Activin_recp	AMHR2 ACVR2A	3.64e-04	10	54	2	IPR000472
Domain	Activin_recp	AMHR2 ACVR2A	3.64e-04	10	54	2	PF01064
Domain	PH	SPTBN5 RASGRF1 OSBPL5 OSBPL6 FERMT3	5.14e-04	229	54	5	PF00169
Domain	TGFB_receptor	AMHR2 ACVR2A	5.32e-04	12	54	2	IPR000333
Domain	Oxysterol-bd	OSBPL5 OSBPL6	5.32e-04	12	54	2	IPR000648
Domain	Oxysterol-bd_CS	OSBPL5 OSBPL6	5.32e-04	12	54	2	IPR018494
Domain	Oxysterol_BP	OSBPL5 OSBPL6	5.32e-04	12	54	2	PF01237
Domain	OSBP	OSBPL5 OSBPL6	5.32e-04	12	54	2	PS01013
Domain	zf-C2H2_6	ZNF684 ZNF566 ZNF790 ZNF420 ZNF850	2.10e-03	314	54	5	PF13912
Domain	KRAB	ZNF684 ZNF566 ZNF790 ZNF420 ZNF850	3.69e-03	358	54	5	PS50805
Domain	KRAB	ZNF684 ZNF566 ZNF790 ZNF420 ZNF850	3.69e-03	358	54	5	PF01352
Domain	Kringle-like	PLA2R1 PRSS12	3.85e-03	32	54	2	IPR013806
Domain	KRAB	ZNF684 ZNF566 ZNF790 ZNF420 ZNF850	4.19e-03	369	54	5	SM00349
Domain	KRAB	ZNF684 ZNF566 ZNF790 ZNF420 ZNF850	4.24e-03	370	54	5	IPR001909
Domain	Myb_DNA-binding	MIER1 MYBL2	4.59e-03	35	54	2	PF00249
Domain	MYB_LIKE	MIER1 MYBL2	5.40e-03	38	54	2	PS50090
Domain	SANT	MIER1 MYBL2	9.20e-03	50	54	2	SM00717
Domain	SANT/Myb	MIER1 MYBL2	9.92e-03	52	54	2	IPR001005
Pathway	REACTOME_DARPP_32_EVENTS	PDE4A PDE4B PDE4C PDE4D	1.21e-07	16	42	4	MM14699
Pathway	WP_SILDENAFIL_TREATMENT	PDE4A PDE4B PDE4C PDE4D	5.78e-07	23	42	4	M46455
Pathway	REACTOME_DARPP_32_EVENTS	PDE4A PDE4B PDE4C PDE4D	6.93e-07	24	42	4	M751
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	PDE4A PDE4B PDE4C PDE4D	2.08e-05	55	42	4	M39763
Pathway	REACTOME_OPIOID_SIGNALLING	PDE4A PDE4B PDE4C PDE4D	5.72e-05	71	42	4	MM14491
Pathway	REACTOME_OPIOID_SIGNALLING	PDE4A PDE4B PDE4C PDE4D	1.44e-04	90	42	4	M6467
Pathway	WP_G_PROTEIN_SIGNALING_PATHWAYS	PDE4A PDE4B PDE4C PDE4D	1.44e-04	90	42	4	MM15882
Pathway	WP_G_PROTEIN_SIGNALING	PDE4A PDE4B PDE4C PDE4D	1.51e-04	91	42	4	M39426
Pubmed	PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.	PDE4A PDE4B PDE4C PDE4D	6.03e-12	4	56	4	32738081
Pubmed	A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.	PDE4A PDE4B PDE4C PDE4D	6.03e-12	4	56	4	8413254
Pubmed	Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.	PDE4A PDE4B PDE4C PDE4D	6.03e-12	4	56	4	9371714
Pubmed	Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.	PDE4A PDE4B PDE4C PDE4D	6.03e-12	4	56	4	24732776
Pubmed	Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.	PDE4A PDE4B PDE4C PDE4D	6.03e-12	4	56	4	22946044
Pubmed	Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.	PDE4A PDE4B PDE4C PDE4D	6.03e-12	4	56	4	34943270
Pubmed	Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.	PDE4A PDE4B PDE4C PDE4D	6.03e-12	4	56	4	33609559
Pubmed	The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.	PDE4A PDE4B PDE4C PDE4D	3.01e-11	5	56	4	33944911
Pubmed	A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons.	PDE4A PDE4B PDE4C PDE4D	3.01e-11	5	56	4	8586960
Pubmed	Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum.	PDE4A PDE4B PDE4C PDE4D	9.02e-11	6	56	4	18923023
Pubmed	Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect.	PDE4A PDE4B PDE4D	3.95e-09	3	56	3	10213096
Pubmed	The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).	PDE4A PDE4B PDE4D	3.95e-09	3	56	3	24555506
Pubmed	Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.	PDE4A PDE4B PDE4D	3.95e-09	3	56	3	18508768
Pubmed	Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.	PDE4A PDE4B PDE4D	3.95e-09	3	56	3	17404263
Pubmed	Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.	PDE4A PDE4B PDE4D	3.95e-09	3	56	3	16034090
Pubmed	Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.	PDE4A PDE4B PDE4D	3.95e-09	3	56	3	15585880
Pubmed	Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.	PDE4A PDE4B PDE4C PDE4D	4.26e-09	13	56	4	8009369
Pubmed	Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.	PDE4A PDE4B PDE4D	1.58e-08	4	56	3	15644445
Pubmed	Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia.	PDE4A PDE4B PDE4D	1.58e-08	4	56	3	11839681
Pubmed	Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.	PDE4A PDE4B PDE4D	1.58e-08	4	56	3	21670503
Pubmed	Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.	PDE4A PDE4B PDE4D	3.94e-08	5	56	3	21652625
Pubmed	Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.	PDE4A PDE4B PDE4D	3.94e-08	5	56	3	28383060
Pubmed	Overview of PDEs and their regulation.	PDE4A PDE4B PDE4C PDE4D	7.43e-08	25	56	4	17307970
Pubmed	Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes.	PDE4A PDE4B PDE4D	1.42e-06	14	56	3	25852085
Pubmed	Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness.	PDE4A PDE4B PDE4D	2.18e-06	16	56	3	28283561
Pubmed	Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma.	PDE4A PDE4B	2.55e-06	2	56	2	21047676
Pubmed	Effects of PDE4 gene polymorphisms on efficacy and adverse drug events of ritodrine therapy in preterm labor patients: a prospective observational study.	PDE4B PDE4D	2.55e-06	2	56	2	31324945
Pubmed	PDE4D plays a critical role in the control of airway smooth muscle contraction.	PDE4B PDE4D	2.55e-06	2	56	2	14519662
Pubmed	Overexpression of phosphodiesterase-4 subtypes involved in surgery-induced neuroinflammation and cognitive dysfunction in mice.	PDE4B PDE4D	2.55e-06	2	56	2	28235598
Pubmed	Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).	PDE4B PDE4D	2.55e-06	2	56	2	17700644
Pubmed	PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.	PDE4B PDE4D	2.55e-06	2	56	2	17088426
Pubmed	PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts.	PDE4B PDE4D	2.55e-06	2	56	2	21288894
Pubmed	Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse.	PDE4A PDE4B	2.55e-06	2	56	2	11267656
Pubmed	Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes.	PDE4A PDE4D	2.55e-06	2	56	2	9520403
Pubmed	Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.	PDE4B PDE4C	2.55e-06	2	56	2	17727341
Pubmed	Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4.	PDE4A PDE4C	2.55e-06	2	56	2	23043089
Pubmed	Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.	PDE4B PDE4D	2.55e-06	2	56	2	29123207
Pubmed	Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.	PDE4B PDE4D	2.55e-06	2	56	2	15003452
Pubmed	Leukocyte phosphodiesterase expression after lipopolysaccharide and during sepsis and its relationship with HLA-DR expression.	PDE4A PDE4B	7.63e-06	3	56	2	28356347
Pubmed	Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication.	PDE4A PDE4B	7.63e-06	3	56	2	11114167
Pubmed	NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.	RASGRF1 SLC4A10 DZIP1	1.13e-05	27	56	3	23359859
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE4A PDE4C PDE4D	1.13e-05	27	56	3	11156964
Pubmed	p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.	PDE4A NGFR	1.52e-05	4	56	2	17576803
Pubmed	mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module.	PDE4A PDE4D	1.52e-05	4	56	2	11296225
Pubmed	Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases.	PDE4A PDE4B	1.52e-05	4	56	2	23008439
Pubmed	Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.	PDE4A PDE4D	2.54e-05	5	56	2	20196770
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	RASGRF1 NGFR PLEKHG5	3.20e-05	38	56	3	11756498
Pubmed	Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism.	OSBPL5 OSBPL6	3.80e-05	6	56	2	10588946
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	RASGRF1 NGFR PLEKHG5	4.66e-05	43	56	3	12376548
Pubmed	DISC1, PDE4B, and NDE1 at the centrosome and synapse.	PDE4B PDE4D	5.32e-05	7	56	2	18983980
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF566 ZNF420 ZNF850	6.91e-05	49	56	3	9630514
Pubmed	Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).	RASGRF1 NGFR PLEKHG5	1.27e-04	60	56	3	12787561
Pubmed	The OSBP-related protein family in humans.	OSBPL5 OSBPL6	1.39e-04	11	56	2	11483621
Pubmed	A family of 12 human genes containing oxysterol-binding domains.	OSBPL5 OSBPL6	1.66e-04	12	56	2	11735225
Pubmed	Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.	PDE4B PDE4D	1.66e-04	12	56	2	19251251
Pubmed	An oxysterol-binding protein family identified in the mouse.	OSBPL5 OSBPL6	1.66e-04	12	56	2	12215260
Pubmed	Retinoic acid selectively inhibits death of basal vomeronasal neurons during late stage of neural circuit formation.	PDE4A PDE4B	2.29e-04	14	56	2	19519663
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	PDE4D RNF213 HERC2	2.56e-04	76	56	3	27542412
Pubmed	An integrated genetic map of the pearl locus of mouse chromosome 13.	PDE4C PDE4D	4.28e-04	19	56	2	8828042
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	RNF213 RNF216 HERC2	4.93e-04	95	56	3	29643511
Pubmed	UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.	RNF213 HERC2	5.24e-04	21	56	2	37422473
Pubmed	Defining the membrane proteome of NK cells.	NBAS OSBPL5 RNF213 GIGYF2 HERC2 IL1RAP DYNC1LI2 FERMT3	5.37e-04	1168	56	8	19946888
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RGPD4 FAM193A GIGYF2 MYBL2 S100PBP	5.65e-04	418	56	5	34709266
Pubmed	Hes1 in the somatic cells of the murine ovary is necessary for oocyte survival and maturation.	AMHR2 NGFR	8.07e-04	26	56	2	23274689
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	PDE4B SH3TC1 NGFR IL1RAP	8.87e-04	265	56	4	19240061
Pubmed	Vti1b promotes TRPV1 sensitization during inflammatory pain.	PFKM RUFY3 DYNC1LI2	1.14e-03	127	56	3	30335684
Cytoband	19q13.12	ZNF566 ZNF790 ZNF420 ZNF850	1.92e-06	72	56	4	19q13.12
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	FAM193A SH3TC1 SPON2	2.56e-03	222	56	3	chr4p16
GeneFamily	Phosphodiesterases	PDE4A PDE4B PDE4C PDE4D	2.58e-07	24	42	4	681
GeneFamily	Type 2 receptor serine/threonine kinases	AMHR2 ACVR2A	5.24e-05	5	42	2	346
GeneFamily	Oxysterol binding proteins\|Pleckstrin homology domain containing	OSBPL5 OSBPL6	3.43e-04	12	42	2	670
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF1 OSBPL5 PLEKHG5 FERMT3	1.31e-03	206	42	4	682
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MIER1 MYBL2	6.73e-03	53	42	2	532
CoexpressionAtlas	DevelopingGonad_e16.5_ovary_emap-9563_k-means-cluster#5_top-relative-expression-ranked_1000	PLA2R1 AMHR2 PHTF2 RNF213 GIGYF2 ZCCHC7	2.14e-05	219	55	6	gudmap_developingGonad_e16.5_ovary_1000_k5
CoexpressionAtlas	DevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#5_top-relative-expression-ranked_1000	PLA2R1 AMHR2 PHTF2 RNF213 GIGYF2 ZCCHC7	2.82e-05	230	55	6	gudmap_developingGonad_e18.5_ovary_1000_k5
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#5_top-relative-expression-ranked_1000	PLA2R1 AMHR2 PHTF2 RNF213 ZCCHC7	9.95e-05	179	55	5	gudmap_developingGonad_e14.5_ ovary_1000_k5
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NBAS SLC4A10 DZIP1 RUFY3 DYNC1LI2	2.59e-06	173	56	5	8bffd512a4e561e23cc04478e2ca6fd5d3771fe4
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NBAS SLC4A10 DZIP1 RUFY3 DYNC1LI2	2.59e-06	173	56	5	3e3c61468e703330788a10d850ef41a85680f86d
ToppCell	CV-Healthy-7\|CV / Virus stimulation, Condition and Cluster	SLC43A2 GIGYF2 IL1RAP RUFY3 S100PBP	3.49e-06	184	56	5	0e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCell	CV-Healthy-7\|Healthy / Virus stimulation, Condition and Cluster	SLC43A2 GIGYF2 IL1RAP RUFY3 S100PBP	3.59e-06	185	56	5	1979d189c204f4c2893e3170a514ee7d5523406c
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-T_cells-MAIT_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRO SLC4A10 NGFR FERMT3	5.39e-05	164	56	4	aff5138b35a06b0819e52855744797bfa343633a
ToppCell	COVID-19-APC-like-Monocyte-derived_macrophages\|COVID-19 / group, cell type (main and fine annotations)	PFKM PLEKHG5 CCDC157 B4GALT3	5.79e-05	167	56	4	854a5dbd43f2b25825a71d37fd7779507783a99a
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRKAG3 AMHR2 MYLK4 BEST3	5.79e-05	167	56	4	d78356bf0c473816dbabaee51984940bd822f84e
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SPON2 OSBPL5 DZIP1 ZNF850	5.79e-05	167	56	4	e242827999caad08b0894d88ab97bc1df41b7650
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF566 NGFR PHTF2 DZIP1	6.94e-05	175	56	4	12f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal-skeletal_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKAG3 MYLK4 BEST3 PFKM	7.25e-05	177	56	4	f6ff1b035fa2418f2448c99d81faa927ece93dfa
ToppCell	droplet-Limb_Muscle-nan-21m-Mesenchymal-skeletal_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKAG3 AMHR2 MYLK4 PFKM	7.74e-05	180	56	4	cea62fc006d68c3815c88bf17ec2617d7e41c3d2
ToppCell	Control-Myeloid\|Control / group, cell type (main and fine annotations)	SLC43A2 PDE4B SH3TC1 IL1RAP	9.73e-05	191	56	4	9c4acc5f3c2f9c0c5520863bb22f391774372347
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLA2R1 SPON2 BEST3 SVEP1	9.73e-05	191	56	4	d4f535b06ad483448ab692e9900c872c78cbed60
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-Th17\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE4D SLC4A10 PHTF2 RNF213	9.73e-05	191	56	4	b3ed4797a7a9810cf3507e0d0f23f45c35bd8ba2
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLA2R1 SPON2 BEST3 SVEP1	9.73e-05	191	56	4	b5210de890d338602857b5907135705a507bc2b0
ToppCell	RA-08._Macrophage\|World / Chamber and Cluster_Paper	SLC43A2 PDE4B SH3TC1 IL1RAP	1.01e-04	193	56	4	5fd22db1825d105709fcc0aa4955c99a117e3c82
ToppCell	Fetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLC43A2 PDE4A SH3TC1 IL1RAP	1.03e-04	194	56	4	3043f6230fa723037c8cf7123f611ae847b39fd4
ToppCell	RA-08._Macrophage\|RA / Chamber and Cluster_Paper	SLC43A2 PDE4B SH3TC1 IL1RAP	1.03e-04	194	56	4	ac26e5c71d5069622de72fa25a9c920887ac2c19
ToppCell	ASK452-Endothelial-Lymphatic\|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq	PDE4C PHTF2 ACVR2A B4GALT3	1.05e-04	195	56	4	20f492299a684ac1b7dd1bbc36a533cd6f9a1c93
ToppCell	distal-Hematologic-EREG+_Dendritic-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLC43A2 PDE4A PDE4B IL1RAP	1.07e-04	196	56	4	c17bb7b3992bfec194bfa310f201a5c64b35868e
ToppCell	moderate-Lymphoid-Treg\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PDE4D SLC4A10 PHTF2 RNF213	1.07e-04	196	56	4	9152f4a8a27ff4ee28f231c5ad00eb2edd9ea6da
ToppCell	COVID-19_Severe-NK\|World / disease group, cell group and cell class	PDE4D SPON2 OSBPL5 RNF213	1.07e-04	196	56	4	f46ca7cc2d8407d0dcaa77c4b16a2c1f2a23734d
ToppCell	distal-2-Hematologic-EREG+_Dendritic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SLC43A2 PDE4A PDE4B IL1RAP	1.10e-04	197	56	4	6fcca7c071e35786b715adeb18be317d34315d7e
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC43A2 PDE4A PDE4B FERMT3	1.10e-04	197	56	4	59aa4a31674125ae422450aee45db3ced5c405d3
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D231\|Adult / Lineage, Cell type, age group and donor	SLC43A2 PDE4B SH3TC1 IL1RAP	1.12e-04	198	56	4	79a415e19cedde13a88f5043d71557363f102322
ToppCell	severe_COVID-19-NK\|World / disease group, cell group and cell class (v2)	PDE4D SPON2 OSBPL5 RNF213	1.12e-04	198	56	4	36b1370ef68c4bbe0268933a6ef5e6022d992bdf
ToppCell	COVID-19_Moderate-NK\|World / disease group, cell group and cell class	PDE4D SPON2 OSBPL5 RNF213	1.14e-04	199	56	4	c41b67b760831c7d5e19fabcc932a056dc560f93
ToppCell	severe-gd_T\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SPON2 OSBPL5 SLC4A10 RNF213	1.14e-04	199	56	4	e5a17a9f8f3be05d6abe1116607d17633df3c7ef
ToppCell	ASK454-Immune-Macrophages\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	TMPPE SPTBN5 MYBL2	1.16e-04	75	56	3	572cea9d3f9afa218037550dacc3524534c673ce
ToppCell	severe-NK\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PDE4D SPON2 OSBPL5 RNF213	1.16e-04	200	56	4	d6767f06fe13be8110a86c2a6029be2dd9ce666c
ToppCell	ASK454-Immune-Macrophages\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	TMPPE SPTBN5 MYBL2	1.20e-04	76	56	3	f4fdc5cb2a561e58ea020dac48ee8647577f9713
Drug	Piclamilast	PDE4A PDE4B PDE4C PDE4D	2.62e-11	4	53	4	DB01791
Drug	Ibudilast	PDE4A PDE4B PDE4C PDE4D	1.31e-10	5	53	4	DB05266
Drug	1,7-naphthyridine	PDE4A PDE4B PDE4C PDE4D	1.31e-10	5	53	4	CID000009209
Drug	Iloprost	PDE4A PDE4B PDE4C PDE4D	9.11e-10	7	53	4	DB01088
Drug	Ketotifen	PDE4A PDE4B PDE4C PDE4D	9.11e-10	7	53	4	DB00920
Drug	Dyphylline	PDE4A PDE4B PDE4C PDE4D	1.82e-09	8	53	4	DB00651
Drug	trequinsin	PDE4A PDE4B PDE4C PDE4D	3.27e-09	9	53	4	ctd:C035964
Drug	L-826,141	PDE4A PDE4B PDE4C PDE4D	3.27e-09	9	53	4	ctd:C459562
Drug	NVP ABE171	PDE4A PDE4B PDE4C PDE4D	5.44e-09	10	53	4	ctd:C451724
Drug	4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid	PDE4A PDE4B PDE4D	1.19e-08	3	53	3	DB08299
Drug	Roflumilast	PDE4A PDE4B PDE4C PDE4D	4.66e-08	16	53	4	ctd:C424423
Drug	Cilomilast	PDE4A PDE4B PDE4C PDE4D	7.81e-08	18	53	4	ctd:C433247
Drug	D-22888	PDE4A PDE4B PDE4D	1.19e-07	5	53	3	CID000197714
Drug	AA-2379	PDE4A PDE4B PDE4C PDE4D	1.52e-07	21	53	4	CID000128390
Drug	HWA 153	PDE4A PDE4B PDE4C PDE4D	1.86e-07	22	53	4	CID000162797
Drug	atherosperminine	PDE4A PDE4B PDE4C PDE4D	2.24e-07	23	53	4	CID000096918
Drug	griseolic acid	PDE4A PDE4B PDE4C PDE4D	2.24e-07	23	53	4	CID000127607
Drug	Ro 15-2041	PDE4A PDE4B PDE4C PDE4D	3.77e-07	26	53	4	CID000132434
Drug	desethyl KBT-3022	PDE4A PDE4B PDE4C PDE4D	3.77e-07	26	53	4	CID000127736
Drug	T-440	PDE4A PDE4B PDE4C PDE4D	3.77e-07	26	53	4	CID000177965
Drug	KF18280	PDE4A PDE4B PDE4D	6.62e-07	8	53	3	CID003071941
Drug	imidazole-4-carboxamide	PDE4A PDE4B PDE4C PDE4D	8.96e-07	32	53	4	CID000152917
Drug	dyphylline	PDE4A PDE4B PDE4C PDE4D	1.02e-06	33	53	4	CID000003182
Drug	AH 21-132	PDE4A PDE4B PDE4C PDE4D	1.63e-06	37	53	4	CID003035793
Drug	Tetrahydrozoline hydrochloride [522-48-5]; Up 200; 16.8uM; HL60; HT_HG-U133A	SPTBN5 PDE4B PDE4D SH3TC1 TRO RUFY3	3.22e-06	175	53	6	2507_UP
Drug	M 98	PDE4B PDE4D	5.32e-06	2	53	2	CID006420180
Drug	V11294 Analogue 5f	PDE4B PDE4D	5.32e-06	2	53	2	CID011214587
Drug	V11294 Analogue 5i	PDE4B PDE4D	5.32e-06	2	53	2	CID011376249
Drug	V11294 Analogue 5t	PDE4B PDE4D	5.32e-06	2	53	2	CID011226695
Drug	V11294 Analogue 5e	PDE4B PDE4D	5.32e-06	2	53	2	CID011443441
Drug	V11294 Analogue 5d	PDE4B PDE4D	5.32e-06	2	53	2	CID011283750
Drug	V11294 Analogue 5n	PDE4B PDE4D	5.32e-06	2	53	2	CID011238279
Drug	3-cyclopentyloxy-4-methoxybenzoic acid	PDE4B PDE4D	5.32e-06	2	53	2	CID002779323
Drug	V11294 Analogue 5v	PDE4B PDE4D	5.32e-06	2	53	2	CID011375325
Drug	V11294 Analogue 5p	PDE4B PDE4D	5.32e-06	2	53	2	CID011478659
Drug	3-cyclopentyloxy-4-methoxybenzaldehyde	PDE4B PDE4D	5.32e-06	2	53	2	CID002735893
Drug	V11294 Analogue 5o	PDE4B PDE4D	5.32e-06	2	53	2	CID011249748
Drug	V11294 Analogue 5c	PDE4B PDE4D	5.32e-06	2	53	2	CID011179896
Drug	V11294 Analogue 5b	PDE4B PDE4D	5.32e-06	2	53	2	CID011443760
Drug	Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid	PDE4B PDE4D	5.32e-06	2	53	2	DB03849
Drug	T-2585.HCl	PDE4B PDE4D	5.32e-06	2	53	2	CID006918355
Drug	Np-V	PDE4B PDE4D	5.32e-06	2	53	2	CID009999276
Drug	V11294 Analogue 5m	PDE4B PDE4D	5.32e-06	2	53	2	CID011477773
Drug	(S)-Rolipram	PDE4B PDE4D	5.32e-06	2	53	2	DB03606
Drug	1-((5-(1-aminoethyl)-2-(8-methoxy-2-(triflurormethyl)-5-quinolinyl)-4-oxazolyl) carbonyl)-4-((cyclopropylcarbonyl)amino)proline ethyl ester	PDE4B PDE4D	5.32e-06	2	53	2	ctd:C554440
Drug	V11294 Analogue 8a	PDE4B PDE4D	5.32e-06	2	53	2	CID011442865
Drug	V11294 Analogue 5r	PDE4B PDE4D	5.32e-06	2	53	2	CID011168555
Drug	V11294 Analogue 5j	PDE4B PDE4D	5.32e-06	2	53	2	CID011433797
Drug	V11294 Analogue 5q	PDE4B PDE4D	5.32e-06	2	53	2	CID011318772
Drug	V11294 Analogue 5a	PDE4B PDE4D	5.32e-06	2	53	2	CID011386897
Drug	V11294 Analogue 5k	PDE4B PDE4D	5.32e-06	2	53	2	CID011456440
Drug	V11294 Analogue 5h	PDE4B PDE4D	5.32e-06	2	53	2	CID011306698
Drug	3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester	PDE4B PDE4D	5.32e-06	2	53	2	DB01959
Drug	4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone	PDE4B PDE4D	5.32e-06	2	53	2	DB01954
Drug	(R)-Rolipram	PDE4B PDE4D	5.32e-06	2	53	2	DB04149
Drug	(4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one	PDE4A PDE4D	5.32e-06	2	53	2	DB06842
Drug	CDP840	PDE4A PDE4B PDE4D	6.53e-06	16	53	3	CID000127928
Drug	Org 4428	PDE4B PDE4D	1.59e-05	3	53	2	CID000166560
Drug	1-Pyrrolidinebutanenitrile	PDE4B PDE4D	1.59e-05	3	53	2	CID000118838
Drug	BW A78U	PDE4B PDE4D	1.59e-05	3	53	2	CID000127779
Drug	Enprofylline	PDE4A PDE4B	1.59e-05	3	53	2	DB00824
Drug	siguazodan	PDE4B PDE4C PDE4D	1.78e-05	22	53	3	CID000072124
Drug	denbufylline	PDE4A PDE4B PDE4D	2.33e-05	24	53	3	CID000002984
Drug	NSC18930	PDE4A PDE4B PDE4C PDE4D	3.12e-05	77	53	4	CID000001189
Drug	AC1O3R20	PDE4A PDE4B PDE4D	3.74e-05	28	53	3	CID006335051
Drug	DTIC	PDE4A PDE4B PDE4C PDE4D	3.81e-05	81	53	4	CID005281007
Drug	motapizone	PDE4A PDE4B PDE4D	4.17e-05	29	53	3	CID000065819
Drug	AC1L73CW	PDE4A PDE4B PDE4C PDE4D	4.40e-05	84	53	4	CID000328776
Drug	Pyrvinium pamoate [3546-41-6]; Up 200; 3.4uM; HL60; HT_HG-U133A	PDE4B PDE4D SH3TC1 IL1RAP RUFY3	4.83e-05	171	53	5	2957_UP
Drug	glycerol-3-phosphocholine	PDE4A PDE4B PDE4C PDE4D NGFR	4.97e-05	172	53	5	CID000000823
Drug	ibudilast	PDE4A PDE4B PDE4D	6.19e-05	33	53	3	CID000003671
Drug	zardaverine	PDE4A PDE4B PDE4D	7.40e-05	35	53	3	CID000005723
Drug	Ketoconazole [65277-42-1]; Up 200; 7.6uM; HL60; HT_HG-U133A	PDE4B SH3TC1 RNF216 IL1RAP RUFY3	7.77e-05	189	53	5	1285_UP
Drug	talniflumate	PDE4B PDE4D	7.93e-05	6	53	2	CID000048229
Drug	4-methylumbelliferyl phenylphosphonate	PDE4B PDE4D	7.93e-05	6	53	2	CID000134928
Drug	Pentoxifylline	PDE4A PDE4B	7.93e-05	6	53	2	DB00806
Drug	Rolipram	PDE4A PDE4B PDE4D	8.75e-05	37	53	3	ctd:D020889
Drug	Dipivefrin hydrochloride [64019-93-8]; Down 200; 10.4uM; PC3; HT_HG-U133A	TNPO2 PHTF2 RNF216 IL1RAP RUFY3	9.22e-05	196	53	5	7124_DN
Drug	Natamycin [7681-93-8]; Down 200; 6uM; HL60; HT_HG-U133A	PDE4A PDE4B PDE4D SPON2 PHTF2	9.90e-05	199	53	5	6126_DN
Drug	RP 73401	PDE4A PDE4B PDE4D	1.03e-04	39	53	3	CID000154575
Drug	Theophylline	PDE4A PDE4B	1.11e-04	7	53	2	DB00277
Drug	nitraquazone	PDE4B PDE4D	1.11e-04	7	53	2	CID000068765
Drug	Ro-1724	PDE4A PDE4B PDE4C PDE4D	1.26e-04	110	53	4	CID000005087
Drug	SCH 51866	PDE4B PDE4D	1.48e-04	8	53	2	CID005311355
Drug	bemoradan	PDE4B PDE4D	1.48e-04	8	53	2	CID005362399
Drug	CC-1104	PDE4B PDE4D	1.48e-04	8	53	2	CID000461664
Drug	PDEs	PDE4A PDE4B PDE4C PDE4D	1.54e-04	116	53	4	CID003036959
Drug	cilomilast	PDE4A PDE4B PDE4D	1.58e-04	45	53	3	CID000151170
Drug	hypoxanthine	PDE4A PDE4B PDE4C PDE4D PFKM	1.58e-04	220	53	5	CID000000790
Drug	cilostamide	PDE4A PDE4B PDE4C PDE4D	1.76e-04	120	53	4	CID000002753
Drug	NVP & EFV	PDE4A PDE4B PDE4D ACVR2A	1.82e-04	121	53	4	CID000492400
Drug	2-pyridinemethanol	PDE4B PDE4D	1.89e-04	9	53	2	CID000011474
Drug	AC1LD7MJ	PDE4B PDE4C PDE4D	2.03e-04	49	53	3	CID000643628
Drug	AWD 12-281	PDE4B PDE4D	2.36e-04	10	53	2	CID006918428
Drug	Tussiglaucin	PDE4B PDE4D	2.36e-04	10	53	2	CID000010145
Drug	9-benzyladenine	PDE4B PDE4D	2.89e-04	11	53	2	CID000020262
Drug	V11294	PDE4B PDE4D	2.89e-04	11	53	2	CID009844400
Drug	zaprinast	PDE4A PDE4B PDE4C PDE4D	3.26e-04	141	53	4	CID000005722
Drug	trequinsin	PDE4B PDE4C PDE4D	3.36e-04	58	53	3	CID000005537
Drug	arofylline	PDE4B PDE4D	3.46e-04	12	53	2	CID000166553
Disease	schizophrenia, gastroesophageal reflux disease	PDE4B GIGYF2	1.66e-04	11	52	2	EFO_0003948, MONDO_0005090
Disease	anxiety disorder, stress-related disorder	PDE4B GIGYF2	1.99e-04	12	52	2	EFO_0006788, EFO_0010098
Disease	sunburn	PDE4B PDE4D HERC2	6.57e-04	96	52	3	EFO_0003958
Disease	Mental Depression	PDE4A PDE4B PDE4D NGFR	1.05e-03	254	52	4	C0011570
Disease	Depressive disorder	PDE4A PDE4B PDE4D NGFR	1.69e-03	289	52	4	C0011581
Disease	progression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian carcinoma	PDE4B PDE4D	2.16e-03	39	52	2	EFO_0001075, EFO_0004920, GO_0097328, MONDO_0009354
Disease	progression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian serous carcinoma	PDE4B PDE4D	2.51e-03	42	52	2	EFO_0004920, EFO_1001516, GO_0097328, MONDO_0009354

Protein segments in the cluster

Peptide	Gene	Start	Entry
DDDDFETNWCIDRNL	BEST3	301	Q8N1M1
EALRDEEWDCLFLHD	B4GALT3	181	O60512
ATEAWECELEGLLEE	PRKAG3	141	Q9UGI9
ETIEECWDHDAEARL	ACVR2A	456	P27037
RRQAEEDEQCLSEWE	CCDC157	326	Q569K6
SEEELRRVAEEWLEC	FAM193A	121	P78312
RELLEDCWDADPEAR	AMHR2	481	Q16671
DDQWDDADAEVICRQ	PRSS12	306	P56730
AWRSGEDADLCSELL	HERC2	211	O95714
LQSDASERCDDWGLD	IL1RAP	16	Q9NPH3
DWRLKECEDASEEPE	SLC43A2	386	Q8N370
QDEEDACWILEDTAC	LBHD1	156	Q9BQE6
EDRDDHTRCNVWILD	DYNC1LI2	96	O43237
DDDWEEHLCRRLSET	PFKM	236	P08237
ARETLEELDWCLEQL	PDE4A	231	P27815
ETLEELDWCLDQLET	PDE4B	221	Q07343
ALETLDELDWCLDQL	PDE4C	206	Q08493
LASETLEELDWCLDQ	PDE4D	276	Q08499
LACRWDLEDEEFQDI	MYLK4	316	Q86YV6
EDLLEWLRPFCADDA	NBAS	2086	A2RRP1
WLQDSEEMDRCAEDL	OSBPL6	251	Q9BZF3
LDNTWEADDVDDDLL	ETAA1	596	Q9NY74
DRDSLPEWCLEDAEE	GIGYF2	281	Q6Y7W6
CLLDEDQALEEWISS	DCAF8L1	131	A6NGE4
WDSLDEDGLDDSLLE	S100PBP	26	Q96BU1
AREELSVWTEEECRN	MIER1	281	Q8N108
ASESDGRCWLDALEL	OSBPL5	226	Q9H0X9
DGEWLCLRELDDISL	RUFY3	36	Q7L099
TLEWDNCDLREDALD	RGPD4	1246	Q7Z3J3
ETEDVLWEDLLHCAE	PHTF2	401	Q8N3S3
DSLDLCDGDRWREQA	SPON2	166	Q9BUD6
ALDLIESDPDAWCDL	MYBL2	311	P10244
CLEAEDDWEDPEALS	SH3TC1	486	Q8TE82
LADDQAIEEDCWLDH	RNF216	161	Q9NWF9
RQLDDFLEDCASELW	KIAA0753	736	Q2KHM9
ERRTCQDDKNWDEDE	SVEP1	2811	Q4LDE5
ALELRTEDAKDCDEW	RASGRF1	106	Q13972
ELKCADVEDEDWDIS	DZIP1	781	Q86YF9
ECTREGREDDLLWCA	PLA2R1	191	Q13018
RAEFLRNCEEEEAWL	SPTBN5	641	Q9NRC6
EERLCRESLADSWGE	CLUL1	101	Q15846
DEQCAVEEALDWRRE	RNF213	1131	Q63HN8
DEDEDNACLRLEDSW	PLEKHG5	306	O94827
DFTAEEWQLLDCAER	ZNF684	16	Q5T5D7
DCLTREELGDDAQAW	TRO	686	Q12816
EDTERQLRECTRWAD	NGFR	171	P08138
DDDDDALSDWNLRKC	TNPO2	361	O14787
DLFTELDEICWREGE	SLC4A10	116	Q6U841
RWDLLLEEIDCTEEE	FERMT3	276	Q86UX7
AVDFSQEEWECLDLE	ZNF790	11	Q6PG37
KERCWEDDDNDNLFL	ZCCHC7	521	Q8N3Z6
SQEEWECLNDDQRDL	ZNF566	16	Q969W8
SQEEWECLDSAQRDL	ZNF420	16	Q8TAQ5
DLSIDFSQEEWECLD	ZNF850	11	A8MQ14
DLLARDAPDTDWCDS	ZP4	131	Q12836
EDWICLAGVDDIEAD	TMPPE	326	Q6ZT21