Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	serine-type endopeptidase activity	PCSK1 PCSK5 CELA3B CELA3A PCSK6 TMPRSS3 PCSK7 MST1L	2.35e-05	190	123	8	GO:0004252
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	GLUD1 GLUD2	3.76e-05	2	123	2	GO:0016639
GeneOntologyMolecularFunction	glutamate dehydrogenase [NAD(P)+] activity	GLUD1 GLUD2	3.76e-05	2	123	2	GO:0004353
GeneOntologyMolecularFunction	glutamate dehydrogenase (NAD+) activity	GLUD1 GLUD2	3.76e-05	2	123	2	GO:0004352
GeneOntologyMolecularFunction	glutamate dehydrogenase (NADP+) activity	GLUD1 GLUD2	3.76e-05	2	123	2	GO:0004354
GeneOntologyMolecularFunction	serine-type peptidase activity	PCSK1 PCSK5 CELA3B CELA3A PCSK6 TMPRSS3 PCSK7 MST1L	4.33e-05	207	123	8	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	PCSK1 PCSK5 CELA3B CELA3A PCSK6 TMPRSS3 PCSK7 MST1L	5.12e-05	212	123	8	GO:0017171
GeneOntologyMolecularFunction	L-leucine binding	GLUD1 GLUD2	7.75e-04	7	123	2	GO:0070728
Domain	P_proprotein	PCSK1 PCSK5 PCSK6 PCSK7	6.17e-08	7	123	4	PF01483
Domain	S8_pro-domain	PCSK1 PCSK5 PCSK6 PCSK7	6.17e-08	7	123	4	IPR032815
Domain	PrprotnconvertsP	PCSK1 PCSK5 PCSK6 PCSK7	6.17e-08	7	123	4	IPR002884
Domain	-	PCSK1 PCSK5 PCSK6 PCSK7	6.17e-08	7	123	4	3.30.70.850
Domain	S8_pro-domain	PCSK1 PCSK5 PCSK6 PCSK7	6.17e-08	7	123	4	PF16470
Domain	Peptidase_S8_His-AS	PCSK1 PCSK5 PCSK6 PCSK7	2.20e-07	9	123	4	IPR022398
Domain	Peptidase_S8_Ser-AS	PCSK1 PCSK5 PCSK6 PCSK7	2.20e-07	9	123	4	IPR023828
Domain	Peptidase_S8_subtilisin-rel	PCSK1 PCSK5 PCSK6 PCSK7	3.65e-07	10	123	4	IPR015500
Domain	SUBTILASE_ASP	PCSK1 PCSK5 PCSK6 PCSK7	3.65e-07	10	123	4	PS00136
Domain	SUBTILASE_HIS	PCSK1 PCSK5 PCSK6 PCSK7	3.65e-07	10	123	4	PS00137
Domain	SUBTILASE_SER	PCSK1 PCSK5 PCSK6 PCSK7	3.65e-07	10	123	4	PS00138
Domain	-	PCSK1 PCSK5 PCSK6 PCSK7	5.70e-07	11	123	4	3.40.50.200
Domain	Peptidase_S8/S53_dom	PCSK1 PCSK5 PCSK6 PCSK7	5.70e-07	11	123	4	IPR000209
Domain	Peptidase_S8	PCSK1 PCSK5 PCSK6 PCSK7	5.70e-07	11	123	4	PF00082
Domain	Propept_inh	PCSK1 PCSK5 PCSK6 PCSK7	3.99e-06	17	123	4	IPR009020
Domain	Peptidase_S8_Asp-AS	PCSK1 PCSK5 PCSK6	5.49e-06	6	123	3	IPR023827
Domain	-	PCSK1 PCSK5 ZZEF1 SSPOP PCSK6 PCSK7	8.57e-06	73	123	6	2.60.120.260
Domain	Galactose-bd-like	PCSK1 PCSK5 ZZEF1 SSPOP PCSK6 PCSK7	3.66e-05	94	123	6	IPR008979
Domain	ELFV_dehydrog_N	GLUD1 GLUD2	4.30e-05	2	123	2	PF02812
Domain	Glu/Leu/Phe/Val_DH_C	GLUD1 GLUD2	4.30e-05	2	123	2	IPR006096
Domain	Glu/Leu/Phe/Val_DH_dimer_dom	GLUD1 GLUD2	4.30e-05	2	123	2	IPR006097
Domain	Glu/Leu/Phe/Val_DH	GLUD1 GLUD2	4.30e-05	2	123	2	IPR006095
Domain	ELFV_dehydrog	GLUD1 GLUD2	4.30e-05	2	123	2	PF00208
Domain	NAD_bind_Glu_DH	GLUD1 GLUD2	4.30e-05	2	123	2	IPR033922
Domain	GLFV_DEHYDROGENASE	GLUD1 GLUD2	4.30e-05	2	123	2	PS00074
Domain	ELFV_dehydrog	GLUD1 GLUD2	4.30e-05	2	123	2	SM00839
Domain	Glu/Leu/Phe/Val_DH_AS	GLUD1 GLUD2	4.30e-05	2	123	2	IPR033524
Domain	RBD-FIP	RAB11FIP1 RAB11FIP3	6.34e-04	6	123	2	PF09457
Domain	GF_recep_IV	PCSK5 PCSK6	6.34e-04	6	123	2	PF14843
Domain	GF_recep_IV	PCSK5 PCSK6	6.34e-04	6	123	2	IPR032778
Domain	Rab-bd_FIP-RBD	RAB11FIP1 RAB11FIP3	6.34e-04	6	123	2	IPR019018
Domain	FIP_RBD	RAB11FIP1 RAB11FIP3	6.34e-04	6	123	2	PS51511
Domain	CRAL_TRIO_2	PRUNE2 ARHGAP8	2.72e-03	12	123	2	PF13716
Domain	PLAC	PCSK5 PCSK6	3.72e-03	14	123	2	PF08686
Domain	Growth_fac_rcpt_	PCSK5 GPR179 PCSK6 TNXB NOTCH4	3.74e-03	156	123	5	IPR009030
Domain	EGF	PCSK5 GPR179 CSPG5 PCSK6 TNXB NOTCH4	4.66e-03	235	123	6	SM00181
Domain	VWF_type-D	SSPOP SUSD2	4.86e-03	16	123	2	IPR001846
Domain	VWFD	SSPOP SUSD2	4.86e-03	16	123	2	PS51233
Domain	VWD	SSPOP SUSD2	4.86e-03	16	123	2	SM00216
Domain	VWD	SSPOP SUSD2	4.86e-03	16	123	2	PF00094
Domain	Furin_repeat	PCSK5 PCSK6	6.14e-03	18	123	2	IPR006212
Domain	FU	PCSK5 PCSK6	6.14e-03	18	123	2	SM00261
Pubmed	Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines.	PCSK1 PCSK5 PCSK6 PCSK7	2.45e-09	6	126	4	8940009
Pubmed	Proteolytic processing in the secretory pathway.	PCSK1 PCSK5 PCSK6 PCSK7	5.70e-09	7	126	4	10409610
Pubmed	The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.	PCSK1 PCSK5 PCSK6 PCSK7	5.70e-09	7	126	4	7819324
Pubmed	Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.	PCSK1 PCSK5 PCSK6 PCSK7	1.14e-08	8	126	4	9885250
Pubmed	Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.	PCSK1 PCSK5 PCSK6 PCSK7	1.14e-08	8	126	4	10037747
Pubmed	The activation and physiological functions of the proprotein convertases.	PCSK1 PCSK5 PCSK6 PCSK7	2.04e-08	9	126	4	18343183
Pubmed	The prohormone theory and the proprotein convertases: it is all about serendipity.	PCSK1 PCSK5 PCSK6 PCSK7	2.04e-08	9	126	4	21805236
Pubmed	The proprotein convertases, 20 years later.	PCSK1 PCSK5 PCSK6 PCSK7	2.04e-08	9	126	4	21805237
Pubmed	The biology and therapeutic targeting of the proprotein convertases.	PCSK1 PCSK5 PCSK6 PCSK7	2.04e-08	9	126	4	22679642
Pubmed	The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.	PCSK1 PCSK5 PCSK6 PCSK7	2.04e-08	9	126	4	23775089
Pubmed	SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.	PCSK1 PCSK5 PCSK6 PCSK7	2.04e-08	9	126	4	8698813
Pubmed	Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.	PCSK1 PCSK5 PCSK6 PCSK7	3.39e-08	10	126	4	16163737
Pubmed	Maturation of HIV envelope glycoprotein precursors by cellular endoproteases.	PCSK5 PCSK6 PCSK7	4.64e-08	3	126	3	11063880
Pubmed	Retroviral envelope glycoprotein processing: structural investigation of the cleavage site.	PCSK5 PCSK6 PCSK7	1.85e-07	4	126	3	9521771
Pubmed	Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.	PCSK1 PCSK5 PCSK6 PCSK7	2.89e-07	16	126	4	20876279
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PRUNE2 ZNF444 CPAMD8 PDE3B HIVEP2 TBKBP1 ACACA BICRA PPP1R9A MAGI3 IQCN PPM1K SSPOP PLEKHG4B ZBTB7A ZFHX2 CACNA1H BAIAP2 PATJ ARHGAP8	4.22e-07	1489	126	20	28611215
Pubmed	Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.	PCSK5 PCSK6 PCSK7	4.62e-07	5	126	3	18664504
Pubmed	Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.	PCSK1 PCSK5 PCSK6	4.62e-07	5	126	3	9242664
Pubmed	Proprotein convertase expression and localization in epidermis: evidence for multiple roles and substrates.	PCSK5 PCSK6 PCSK7	4.62e-07	5	126	3	11380615
Pubmed	Murine subtilisin-like proteinase SPC6 is expressed during embryonic implantation, somitogenesis, and skeletal formation.	PCSK1 PCSK5 PCSK6	9.21e-07	6	126	3	9291583
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	ACACA GLYCTK PSMB5 SCYL1 DIDO1 RAB11FIP1 ARHGEF15 FASN SLC16A3 GLUD2 SEC16A SLC33A1 NOTCH4	3.81e-06	754	126	13	35906200
Pubmed	Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.	MYCL GLUD1 GLUD2	3.84e-06	9	126	3	8415706
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PCSK5 NRDE2 RALGDS PDE3B PSMB5 DIDO1 GIGYF1 ZZEF1 PATJ EPN1 SLC33A1 PLXNB1	4.61e-06	650	126	12	38777146
Pubmed	Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?	AVEN ACACA HTR7 CRHR1 FASN ADRA2A NOTCH4	6.79e-06	192	126	7	20602615
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MYCL PCSK5 TEAD2 HIVEP2 TBKBP1 ACACA KIF26A BICRA ZNF316 IRAK1 ZZEF1 FASN SEC16A CACNA1H RAB11FIP3	1.18e-05	1105	126	15	35748872
Pubmed	Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	1.30e-05	2	126	2	15750346
Pubmed	Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.	GLUD1 GLUD2	1.30e-05	2	126	2	1711373
Pubmed	Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.	GLUD1 GLUD2	1.30e-05	2	126	2	34173171
Pubmed	Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.	GLUD1 GLUD2	1.30e-05	2	126	2	28621566
Pubmed	GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.	GLUD1 GLUD2	1.30e-05	2	126	2	32078638
Pubmed	Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.	GLUD1 GLUD2	1.30e-05	2	126	2	20529287
Pubmed	Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.	GLUD1 GLUD2	1.30e-05	2	126	2	23595828
Pubmed	Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).	GLUD1 GLUD2	1.30e-05	2	126	2	25124006
Pubmed	Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis.	CELA3B CELA3A	1.30e-05	2	126	2	27999401
Pubmed	Unexpected histone H3 tail-clipping activity of glutamate dehydrogenase.	GLUD1 GLUD2	1.30e-05	2	126	2	23673664
Pubmed	Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases.	PCSK5 PCSK6	1.30e-05	2	126	2	18061232
Pubmed	Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways.	GLUD1 GLUD2	1.30e-05	2	126	2	21621574
Pubmed	Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.	GLUD1 GLUD2	1.30e-05	2	126	2	39052831
Pubmed	Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.	GLUD1 GLUD2	1.30e-05	2	126	2	24442550
Pubmed	Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.	GLUD1 GLUD2	1.30e-05	2	126	2	28911206
Pubmed	The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity.	GLUD1 GLUD2	1.30e-05	2	126	2	27137930
Pubmed	GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.	GLUD1 GLUD2	1.30e-05	2	126	2	26440896
Pubmed	Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.	GLUD1 GLUD2	1.30e-05	2	126	2	22875990
Pubmed	Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.	GLUD1 GLUD2	1.30e-05	2	126	2	12742085
Pubmed	Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.	GLUD1 GLUD2	1.30e-05	2	126	2	15578726
Pubmed	Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	1.30e-05	2	126	2	15044002
Pubmed	Induction of excitatory and inhibitory presynaptic differentiation by GluD1.	GLUD1 GLUD2	1.30e-05	2	126	2	22138648
Pubmed	Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.	GLUD1 GLUD2	1.30e-05	2	126	2	34220417
Pubmed	Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.	GLUD1 GLUD2	1.30e-05	2	126	2	26241911
Pubmed	Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease.	PCSK5 PCSK6	1.30e-05	2	126	2	8335106
Pubmed	Association study between the TNXB locus and schizophrenia in a Japanese population.	TNXB NOTCH4	1.30e-05	2	126	2	17192952
Pubmed	Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.	GLUD1 GLUD2	1.30e-05	2	126	2	21446915
Pubmed	Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection.	GLUD1 GLUD2	1.30e-05	2	126	2	18688271
Pubmed	The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.	GLUD1 GLUD2	1.30e-05	2	126	2	22658952
Pubmed	Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4.	PCSK5 PCSK6	1.30e-05	2	126	2	8468318
Pubmed	GluD1 binds GABA and controls inhibitory plasticity.	GLUD1 GLUD2	1.30e-05	2	126	2	38060673
Pubmed	Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.	GLUD1 GLUD2	1.30e-05	2	126	2	24593767
Pubmed	Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport.	GLUD1 GLUD2	1.30e-05	2	126	2	38124277
Pubmed	Potentiation of neuronal activity by tonic GluD1 current in brain slices.	GLUD1 GLUD2	1.30e-05	2	126	2	37154294
Pubmed	Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.	GLUD1 GLUD2	1.30e-05	2	126	2	19015267
Pubmed	Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.	GLUD1 GLUD2	1.30e-05	2	126	2	22924626
Pubmed	Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.	GLUD1 GLUD2	1.30e-05	2	126	2	19448744
Pubmed	Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.	GLUD1 GLUD2	1.30e-05	2	126	2	11032875
Pubmed	Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.	GLUD1 GLUD2	1.30e-05	2	126	2	11950837
Pubmed	Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.	GLUD1 GLUD2	1.30e-05	2	126	2	29943084
Pubmed	Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning.	CELA3B CELA3A	1.30e-05	2	126	2	2826474
Pubmed	Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes.	CELA3B CELA3A	1.30e-05	2	126	2	2460440
Pubmed	Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.	GLUD1 GLUD2	1.30e-05	2	126	2	31898404
Pubmed	Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.	GLUD1 GLUD2	1.30e-05	2	126	2	15378063
Pubmed	Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.	GLUD1 GLUD2	1.30e-05	2	126	2	27422263
Pubmed	The gene expression of the main lipogenic enzymes is downregulated in visceral adipose tissue of obese subjects.	ACACA FASN	1.30e-05	2	126	2	19543203
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	BICRA ZNF316 IRAK1 PDCD2L GIGYF1 RAB11FIP1 ZZEF1 MSH6 ZBTB7A ZNF469 PCSK6 FIZ1 SEC16A TNRC6A ZNF646	1.33e-05	1116	126	15	31753913
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	AVEN BLOC1S4 SCYL1 PACSIN3 IRAK1 PDCD2L GIGYF1 RAB11FIP1 SOX13 SEC16A TBC1D12 CCAR2 EPN1 TEDC1	2.53e-05	1038	126	14	26673895
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	PRUNE2 BICRA ASAP3 SCYL1 LMTK3 PLEKHG4B ZNF469 PATJ EPN1	2.86e-05	430	126	9	35044719
Pubmed	Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.	GLUD1 GLUD2	3.90e-05	3	126	2	29784783
Pubmed	Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.	PCSK1 PCSK7	3.90e-05	3	126	2	22396549
Pubmed	The structure of apo human glutamate dehydrogenase details subunit communication and allostery.	GLUD1 GLUD2	3.90e-05	3	126	2	12054821
Pubmed	Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study.	PCSK1 PCSK7	3.90e-05	3	126	2	12358783
Pubmed	Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons.	GLUD1 GLUD2	3.90e-05	3	126	2	31704028
Pubmed	The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells.	PCSK1 PCSK7	3.90e-05	3	126	2	8995623
Pubmed	Secretion of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with rapamycin.	ACACA FASN	3.90e-05	3	126	2	21281598
Pubmed	Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase.	GLUD1 GLUD2	3.90e-05	3	126	2	29229616
Pubmed	Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis.	GLUD1 GLUD2	3.90e-05	3	126	2	30002133
Pubmed	Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens.	GLUD1 GLUD2	3.90e-05	3	126	2	30315226
Pubmed	Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17.	PCSK1 PCSK5	3.90e-05	3	126	2	18554181
Pubmed	Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN).	ZBTB7A FASN	3.90e-05	3	126	2	18682402
Pubmed	Radioligand binding analysis of knockout mice reveals 5-hydroxytryptamine(7) receptor distribution and uncovers 8-hydroxy-2-(di-n-propylamino)tetralin interaction with alpha(2) adrenergic receptors.	HTR7 ADRA2A	3.90e-05	3	126	2	15026130
Pubmed	Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases.	PCSK5 PCSK6	3.90e-05	3	126	2	8670066
Pubmed	PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism.	PCSK1 PCSK5	3.90e-05	3	126	2	17645548
Pubmed	Isolation of a human brain cDNA for glutamate dehydrogenase.	GLUD1 GLUD2	3.90e-05	3	126	2	3585334
Pubmed	The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6.	PCSK1 PCSK5	3.90e-05	3	126	2	18096669
Pubmed	The lipogenesis pathway as a cancer target.	ACACA FASN	3.90e-05	3	126	2	21726077
Pubmed	GOT1 regulates CD8+ effector and memory T cell generation.	GLUD1 GLUD2	3.90e-05	3	126	2	36640309
Pubmed	Screening for new inhibitors of the human Mitochondrial Pyruvate Carrier and their effects on hepatic glucose production and diabetes.	GLUD1 GLUD2	3.90e-05	3	126	2	37871770
Pubmed	Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains.	PCSK5 PCSK7	3.90e-05	3	126	2	11723118
Pubmed	Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning.	GLUD1 GLUD2	3.90e-05	3	126	2	23560106
Pubmed	Subtilisin-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head.	PCSK1 PCSK6	3.90e-05	3	126	2	19339735
Pubmed	Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.	ACACA FASN	3.90e-05	3	126	2	18455495
Pubmed	Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.	GLUD1 GLUD2	3.90e-05	3	126	2	20670938
Pubmed	Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells.	PCSK6 PCSK7	3.90e-05	3	126	2	10050053
Cytoband	17q25	FASN SLC16A3 BAIAP2	1.72e-04	39	126	3	17q25
Cytoband	1p36.12	ASAP3 CELA3B CELA3A	1.72e-04	39	126	3	1p36.12
Cytoband	17q21.1	MSL1 GPR179	1.37e-03	20	126	2	17q21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr17q25	CDC42EP4 FN3KRP FASN SLC16A3 BAIAP2	1.64e-03	307	126	5	chr17q25
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	FAM110D ASAP3 CCDC27 CELA3B CELA3A MST1L KLHDC7A	2.83e-03	681	126	7	chr1p36
Cytoband	9q34.3	RALGDS SEC16A RNF208	3.17e-03	106	126	3	9q34.3
GeneFamily	Proprotein convertase subtilisin/kexin family	PCSK1 PCSK5 PCSK6 PCSK7	5.90e-08	9	86	4	973
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	PRUNE2 ARHGAP8	4.62e-04	7	86	2	1299
Coexpression	GSE36476_YOUNG_VS_OLD_DONOR_MEMORY_CD4_TCELL_40H_TSST_ACT_UP	NRDE2 PPP1R9A ASAP3 CRHR1 OPRK1 ALPK3 CACNA1H ZNF646	4.82e-06	195	126	8	M5318
ToppCell	droplet-Kidney-KIDNEY-1m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 PCSK5 TEAD2 TBKBP1 KIF26A FAM110D SOX13 ARHGEF15 NOTCH4	4.17e-09	192	126	9	c0498baa2556e1597c00df2e75efadeb14bd34ef
ToppCell	droplet-Kidney-KIDNEY-1m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 PCSK5 TEAD2 TBKBP1 KIF26A FAM110D SOX13 ARHGEF15 NOTCH4	4.17e-09	192	126	9	cb906b10cad76e978c5c0b966215368ebef30e51
ToppCell	Mesenchymal_cells-Osteoblasts\|World / Lineage and Cell class	FAM110D SERPINF1 BFSP1 ZNF469 PCSK6 CREB3L3 PLXNB1 TDRP	6.60e-08	188	126	8	89f7f5a51be7e046a63e2413f86c521ae4b6718f
ToppCell	droplet-Kidney-nan-21m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 PCSK5 TEAD2 KIF26A FAM110D SOX13 ARHGEF15 NOTCH4	6.88e-08	189	126	8	2ce330d8078833c05775c481e73770f9ee4a5c88
ToppCell	droplet-Kidney-nan-21m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 PCSK5 TEAD2 KIF26A FAM110D SOX13 ARHGEF15 NOTCH4	6.88e-08	189	126	8	473c87036e04a058b4a5138438b7ba7e1e766799
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells-neuroepithelial-like_cells\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	AVEN RALGDS ACACA IRAK1 SLC18B1 ABCB10 TMPRSS3	4.99e-07	167	126	7	e488d9c7cf4355959e3833de3bd496c13fc11b1b
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D122\|Adult / Lineage, Cell type, age group and donor	CPAMD8 KIF26A ZNF423 SOX13 ARHGEF15 FIGLA NOTCH4	5.19e-07	168	126	7	8c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	ACACA PPP1R9A MAGI3 TACC2 PLEKHG4B PATJ ARHGAP8	9.91e-07	185	126	7	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	Control-Epithelial-Club\|World / Disease state, Lineage and Cell class	CPAMD8 PPP1R9A MAGI3 TACC2 SUSD2 PATJ TDRP	1.03e-06	186	126	7	9798428691408e17ff2af2fe2d1b345f074d67e4
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 PCSK5 KIF26A SERPINF1 GPR88 ARHGEF15 NOTCH4	1.07e-06	187	126	7	e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	PPP1R9A MAGI3 TACC2 RAB11FIP1 FASN PATJ ARHGAP8	1.10e-06	188	126	7	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 TEAD2 KIF26A FAM110D SOX13 ARHGEF15 NOTCH4	1.18e-06	190	126	7	cb8798839c27f307955fcc94a1ee40bca95b8e99
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 TEAD2 KIF26A FAM110D SOX13 ARHGEF15 NOTCH4	1.18e-06	190	126	7	5bf3d0beee69879c95265d07fba023626a7cc808
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 PCSK5 TEAD2 KIF26A SOX13 ARHGEF15 NOTCH4	1.23e-06	191	126	7	b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCell	droplet-Kidney-nan-18m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 PCSK5 TEAD2 KIF26A FAM110D ARHGEF15 NOTCH4	1.27e-06	192	126	7	144503af50274eaed5cf6effa892c640eab28663
ToppCell	droplet-Kidney-nan-18m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 PCSK5 TEAD2 KIF26A FAM110D ARHGEF15 NOTCH4	1.27e-06	192	126	7	c96736bb3a6bb052678b1b078f7823063ca69e6d
ToppCell	Tracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF17 ADRA2A SUSD2 ALPK3 PCSK7 CACNA1H NPAS4	1.61e-06	199	126	7	c2903b1a4b91e94bbdaa909bacefe901255cf248
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	PRUNE2 PCSK5 SERPINF1 TACC2 DCLK3 HS3ST3A1 TNXB	1.67e-06	200	126	7	02cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYCL PPM1K PLEKHG4B TMPRSS3 ZFHX2 SLX4	5.72e-06	157	126	6	4766f7d545bf2d775390589460677519cb92f4d5
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Mast\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRUNE2 RAB44 SLC16A3 TMPRSS3 DCLK3 HS3ST3A1	6.38e-06	160	126	6	6393e3d5c5c8176c93aecd89b313bd054a00d474
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Mast-Mast_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRUNE2 RAB44 SLC16A3 TMPRSS3 DCLK3 HS3ST3A1	6.38e-06	160	126	6	2065938e944eb99478fd8132c2c03adeaee6d447
ToppCell	Control\|World / group, cell type (main and fine annotations)	PPP1R9A MAGI3 TACC2 IQCN RAB11FIP1 PATJ	8.43e-06	168	126	6	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF423 FAM110D SOX13 RASL10A CSPG5 ARMCX6	9.02e-06	170	126	6	50c6c571591aa4b218caefe5778c570c809f567e
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF423 FAM110D SOX13 RASL10A CSPG5 ARMCX6	9.02e-06	170	126	6	8fe32dcf924d5f6665f7febbc9647d96b1e96f06
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CPAMD8 ACACA MAGI3 LMTK3 BAIAP2 PATJ	9.02e-06	170	126	6	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF423 FAM110D SOX13 RASL10A CSPG5 ARMCX6	9.02e-06	170	126	6	3232db50b1a40f861e981a1b9c9073b81af9f832
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ACACA SERPINF1 SUSD2 CCAR2 PATJ TEDC1	1.03e-05	174	126	6	a1f745962a104c6f4b86b7e482da8755384c773a
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-6\|TCGA-Pancreas / Sample_Type by Project: Shred V9	KIF26A FAM110D REG3G ARHGEF15 CELA3B CELA3A	1.03e-05	174	126	6	9ad13d4613c4f80bdd8033cc1ecf60eda7c0e6e5
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Paneth\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYCL PCSK1 REG3G TMPRSS3 PLXNB1 ZNF646	1.06e-05	175	126	6	24651f95540ea2c8f3720aa943cbdd15661ee3fa
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	ACACA SERPINF1 SUSD2 CCAR2 PATJ TEDC1	1.06e-05	175	126	6	78a86cac3e6c0d115c997d1c29ee0e24af54551f
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK1 PDE3B OPRK1 CELA3B CELA3A SUSD2	1.13e-05	177	126	6	c80893e5cf5688ee9f5afc8f11b3890f296c9e1f
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK1 GPR6 OPRK1 CELA3B CELA3A SUSD2	1.29e-05	181	126	6	af031661af28f99d906d8e013b4949133b44a2e6
ToppCell	facs-Heart-RA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDC42EP4 HTR7 PACSIN3 ARHGEF17 CCAR2 PLXNB1	1.37e-05	183	126	6	0f02136359787bd78146617990968baa47a65d86
ToppCell	Mesenchymal_cells-Osteoblasts\|Mesenchymal_cells / Lineage and Cell class	FAM110D SERPINF1 BFSP1 ZNF469 CREB3L3 TDRP	1.37e-05	183	126	6	d6b52d52fe9a7a6c798947f05420d79fe12e4662
ToppCell	facs-Heart-RA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDC42EP4 HTR7 PACSIN3 ARHGEF17 CCAR2 PLXNB1	1.37e-05	183	126	6	2f0dcc65ad4d90ef946919b4462280fdd20c5ea0
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	ACACA PPP1R9A MAGI3 TACC2 FASN PATJ	1.41e-05	184	126	6	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-Progenitor_(NEUROG3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYCL PCSK1 OPRK1 CELA3B CELA3A SUSD2	1.46e-05	185	126	6	2088e82e0febdcf05618d3db913d00e2e87812f4
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZNF423 SERPINF1 GPR88 PCSK6 CACNA1H RAB11FIP3	1.46e-05	185	126	6	1b990e3089772be2b38c6d7ea0d1bf22461ae3ea
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a\|Striatum / BrainAtlas - Mouse McCarroll V32	GPR6 HTR7 GPR88 CRHR1 BAIAP2	1.47e-05	109	126	5	e8e0f2c5f8c9e45f2b4d173569c94275eedfe432
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAGI3 RAB11FIP1 PLEKHG4B SUSD2 BAIAP2 PATJ	1.50e-05	186	126	6	3aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell	COPD-Epithelial-Club\|World / Disease state, Lineage and Cell class	PPP1R9A MAGI3 TACC2 SUSD2 PATJ TDRP	1.50e-05	186	126	6	3006f4ab1eaf1eb34c10ca9f7c869603d2d25744
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CPAMD8 MAGI3 RAB11FIP1 PLEKHG4B SUSD2 PATJ	1.55e-05	187	126	6	4ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCell	P07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PCSK5 FAM110D SOX13 ARMCX6 ARHGAP8 NOTCH4	1.60e-05	188	126	6	5bc1537e079c7435196c163bff5f639ea392a33a
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	PCSK5 ZNF423 FAM110D RAB44 ARHGEF15 NOTCH4	1.60e-05	188	126	6	c90669b51e1902fe7726555290c91c92a911df83
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTR7 PACSIN3 ARHGEF17 SUSD2 NPAS4 PLXNB1	1.65e-05	189	126	6	de51fbd6fdb24fc4549393cf41a020005444b2aa
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTR7 PACSIN3 ARHGEF17 SUSD2 NPAS4 PLXNB1	1.70e-05	190	126	6	1d8e169d2448a34180c415843bb49aa45ed540c5
ToppCell	COVID-19-lung-AT2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ACACA PPP1R9A MAGI3 TACC2 FASN SUSD2	1.70e-05	190	126	6	27a1a86620fe9b5ee930d388b32352206485e6d0
ToppCell	COPD-Epithelial-Club\|COPD / Disease state, Lineage and Cell class	PPP1R9A MAGI3 TACC2 SUSD2 PATJ TDRP	1.75e-05	191	126	6	c909cf5fa0e6519aa93a47d2c3fcd2ae2163cd8d
ToppCell	facs-Lung-EPCAM-24m-Epithelial-Neuroendocrine\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK1 PRUNE2 LMTK3 CCAR2 CACNA1H RNF208	1.75e-05	191	126	6	501d4f6ad389d9ac5051d4247b9bd3da96f713f9
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ACACA PPP1R9A MAGI3 TACC2 FASN PATJ	1.75e-05	191	126	6	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	ACACA PPP1R9A MAGI3 TACC2 FASN PATJ	1.75e-05	191	126	6	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	facs-Lung-EPCAM-24m-Epithelial-lung_neuroendocrine_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK1 PRUNE2 LMTK3 CCAR2 CACNA1H RNF208	1.75e-05	191	126	6	8e06cc61eaff1796c2ce014074029408ba88d561
ToppCell	Control-Epithelial-Club\|Control / Disease state, Lineage and Cell class	CPAMD8 PPP1R9A MAGI3 TACC2 PATJ TDRP	1.80e-05	192	126	6	d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	ACACA PPP1R9A MAGI3 TACC2 FASN PATJ	1.80e-05	192	126	6	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3B ZNF423 PPP1R9A ARHGEF15 PCSK6 NOTCH4	1.85e-05	193	126	6	e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	PPP1R9A MAGI3 DIDO1 PCSK6 TNRC6A PATJ	1.85e-05	193	126	6	503a979328c68b096680b71359a26f02fafdff35
ToppCell	LA\|World / Chamber and Cluster_Paper	PRUNE2 PCSK5 SERPINF1 FASN PCSK6 TNXB	1.85e-05	193	126	6	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	Endothelial-A-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	KIF26A ZNF423 FAM110D ARHGEF15 TNXB NOTCH4	1.91e-05	194	126	6	e656ac5539e59e321b46706cb8cc423b2c3358a0
ToppCell	EC-Arteriolar_ECs\|World / Lineage and Cell class	PRUNE2 KIF26A FAM110D SOX13 ARHGEF15 NOTCH4	1.91e-05	194	126	6	38f0c52de252101d4bc8633af80002061635e487
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK1 PRUNE2 LMTK3 ARHGEF17 ADRA2A ZFHX2	1.96e-05	195	126	6	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	Influenza-Influenza_Severe-Myeloid-pDC\|Influenza_Severe / Disease, condition lineage and cell class	SERPINF1 PDCD2L PPM1K ZNF469 ROBO3 NOTCH4	2.08e-05	197	126	6	e8e6f71e6dc8a695e4321a18543c1df63dd62f3e
ToppCell	Healthy/Control-cDC\|World / Disease group and Cell class	MYCL HTR7 SERPINF1 ZNF469 TBC1D12 BAIAP2	2.08e-05	197	126	6	4497d4073f4d3e74de907325fba9eb4af5766bf4
ToppCell	Healthy/Control-cDC\|Healthy/Control / Disease group and Cell class	MYCL HTR7 SERPINF1 ZNF469 TBC1D12 BAIAP2	2.08e-05	197	126	6	926423aae9fcf654f84b0f7621103a6a22d3aced
ToppCell	Healthy_donor-cDC\|World / disease group, cell group and cell class (v2)	MYCL HTR7 SERPINF1 ZNF469 TBC1D12 BAIAP2	2.08e-05	197	126	6	a545fe3a80cd721bf01115bbb645753840ec9f40
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Smooth_muscle-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	ARSI ADRA2A SUSD2 ANO7 CACNA1H NPAS4	2.14e-05	198	126	6	0f1feed8a37293ae02465909f99548ab58dc7ce5
ToppCell	distal-Epithelial-Alveolar_Epithelial_Type_1-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KLRG2 MAGI3 TACC2 RAB11FIP1 SUSD2 PATJ	2.20e-05	199	126	6	c1daa481f88d5281b6b5ea8ec8bb70cc0907d613
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Artery\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	PCSK5 CPAMD8 FAM110D SOX13 ARHGEF15 NOTCH4	2.26e-05	200	126	6	34b279804475ea58fbb052b96f44128c082627a9
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	PRUNE2 PCSK5 TACC2 CSPG5 DCLK3 HS3ST3A1	2.26e-05	200	126	6	c5e051f1aac8dda376c342a9932785a23450e073
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Artery\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PCSK5 CPAMD8 FAM110D SOX13 ARHGEF15 NOTCH4	2.26e-05	200	126	6	8552cc7a439449b30b59760c3e8667217b9852b5
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PRUNE2 PCSK5 SERPINF1 TACC2 HS3ST3A1 TNXB	2.26e-05	200	126	6	87827041663013f5e7273168dc8709d69840e7ce
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	PRUNE2 PCSK5 SERPINF1 TACC2 DCLK3 HS3ST3A1	2.26e-05	200	126	6	593bf6a7c557437db9a9249a5058a46014179ef6
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PRUNE2 PCSK5 SERPINF1 TACC2 HS3ST3A1 TNXB	2.26e-05	200	126	6	08bf8c00eee6468215edb3611296bfc8784c4d56
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Artery-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PCSK5 CPAMD8 FAM110D SOX13 ARHGEF15 NOTCH4	2.26e-05	200	126	6	45c08f1befe78553bbadcc2fcffb6138306638f3
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Cervical_Squamous_Cell_Carcinoma-4\|TCGA-Cervix / Sample_Type by Project: Shred V9	CPAMD8 PPP1R9A CRHR1 PLEKHG4B DZIP3	3.19e-05	128	126	5	3ca9ae69fb8cb7f8acb7540aa71778bc917da4df
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Acinar_Adenocarcinoma-7\|TCGA-Lung / Sample_Type by Project: Shred V9	MAGI3 NT5C1A SHF SUSD2 MST1L	3.44e-05	130	126	5	0219d0d5d21df08f816569c7eb34f1bfa095d29a
ToppCell	Epithelial-B_(AT1-AT2-progenitors)\|World / shred on cell class and cell subclass (v4)	PPP1R9A MAGI3 FASN PATJ ARHGAP8	5.98e-05	146	126	5	4511916904c1fac252cb68e871b782207f8137b3
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CRHR1 ZFHX2 CACNA1H BAIAP2 ROBO3	6.18e-05	147	126	5	8f725ff8fb4ced5db2643e80669d3f7945b820ab
ToppCell	3'-GW_trimst-1-LargeIntestine-Epithelial-neuro-epithelial-Progenitor_(NEUROG3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYCL OPRK1 CELA3B CELA3A SUSD2	7.47e-05	153	126	5	20786807bba3bcd70ce744f8b6454e064199ed9f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK5 KIF26A GLUD2 NOTCH4 TEDC1	7.70e-05	154	126	5	e51a5114f0ec38f997f5b8bbf3a7770f98595474
ToppCell	severe_COVID-19-cDC\|severe_COVID-19 / disease group, cell group and cell class (v2)	HTR7 SERPINF1 ZNF469 ALPK3 BAIAP2	8.44e-05	157	126	5	ec1978e07e2214048d015d8bb793c1d9991f6e37
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CPAMD8 MAGI3 TACC2 CSPG5 ARHGAP8	8.96e-05	159	126	5	8680b054622f573a82b1625fb93c2d5db81d1034
ToppCell	3'-GW_trimst-1-LargeIntestine-Epithelial-neuro-epithelial\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK1 GPR179 CELA3B CELA3A SUSD2	9.22e-05	160	126	5	6c89a2e4189e4f2b6b09b66c6aae6653785ab2f8
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYCL HTR7 SERPINF1 SSPOP ALPK3	9.50e-05	161	126	5	76c993a4533362db2250c88b3ee3ede55362d54e
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PPP1R9A MAGI3 RAB11FIP1 FASN PATJ	9.78e-05	162	126	5	06f5d6c0bb26fe9d5180bc2ebf2c54bf52e715f3
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PPP1R9A MAGI3 RAB11FIP1 FASN PATJ	9.78e-05	162	126	5	d0d9c18a73bc0bf4f38308ef2eee8ae20f6a7918
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SERPINF1 CCDC27 CELA3B PCSK6 TNXB	9.78e-05	162	126	5	56f1789e69a6cb29956e46aba92b290847327c1f
ToppCell	facs-Aorta-Heart-24m-Endothelial-endocardial_endothelial_cells\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF423 CRHR1 BFSP1 ADRA2A ARHGAP8	1.16e-04	168	126	5	edbab94f14e16a1a76546a18fe777a183080d1de
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACACA SERPINF1 FASN PCSK6 CREB3L3	1.16e-04	168	126	5	b98af4043dfa5dfa4413e482879fad88de484675
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACACA SERPINF1 FASN PCSK6 CREB3L3	1.16e-04	168	126	5	073b53d4cee6bc8c5c6fce51cf6cd9c316478f69
ToppCell	droplet-Liver-HEPATOCYTES\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACACA SERPINF1 FASN PCSK6 CREB3L3	1.19e-04	169	126	5	f195467438c589f87224bde7da720dea072d110c
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PCSK1 KIF26A ARHGEF15 TNXB NOTCH4	1.19e-04	169	126	5	0d8b681404e18f3061d84425fb5f7d84e8e2b8d7
ToppCell	droplet-Liver-HEPATOCYTES-1m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACACA SERPINF1 FASN PCSK6 CREB3L3	1.19e-04	169	126	5	7785cab967a33560830c394c918d6ce625103858
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYCL HTR7 SERPINF1 KLRG2 SSPOP	1.19e-04	169	126	5	9c9bb1b32fc6e22359424a262178906c3954415d
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-Progenitor_(NEUROG3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYCL CELA3B CELA3A SUSD2 ARHGAP8	1.26e-04	171	126	5	c54dcad75fc378da1943009d7dd872b39ea337c0
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_28\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KIF26A FAM110D GPR179 TDRP ZNF646	1.33e-04	173	126	5	66488d01e03264fb193285470901c9c4182fbae8
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PCSK5 ARHGEF15 SLC22A18AS GLUD2 NOTCH4	1.33e-04	173	126	5	3a9e9a09b3eeb37cbe56d650e112a8398879477f
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____podocyte-3\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCL HTR7 KLRG2 REG3G RASL10A	1.37e-04	174	126	5	76310c0af1d7df6a4de3816838b2ac2892f68746
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_AB\|TCGA-Thymus / Sample_Type by Project: Shred V9	PRUNE2 CPAMD8 GPR88 SLC22A18AS SHF	1.40e-04	175	126	5	50f9b994bdd389158f92f891944ea81b2fb15eef
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PCSK5 KIF26A SOX13 ARHGEF15 NOTCH4	1.48e-04	177	126	5	5ff8dcfb030312126695d53a026d2e104a401b83
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCSK1 ZNF444 GPR179 CCAR2 NPAS4	1.48e-04	177	126	5	8abdf1d970b2f15e17e185f3e612dd5065c88757
Drug	Sulfamethizole [144-82-1]; Down 200; 14.8uM; MCF7; HT_HG-U133A	MYCL ZNF444 PDE3B BICRA SOX13 ZBTB7A SLC16A3 DZIP3 PLXNB1	1.37e-06	194	126	9	6272_DN
Drug	Spectinomycin dihydrochloride [21736-83-4]; Down 200; 9.8uM; MCF7; HT_HG-U133A	SERPINF1 SOX13 ZBTB7A SLC16A3 CEP250 DZIP3 ZFHX2 PATJ RAB11FIP3	1.49e-06	196	126	9	3327_DN
Drug	AC1NRA4I	FASN GLUD1 GLUD2	1.64e-06	5	126	3	CID005287695
Drug	Meclozine dihydrochloride [1104-22-9]; Down 200; 8.6uM; MCF7; HT_HG-U133A	MYCL ARHGEF17 MINDY2 SLC22A18AS ZBTB7A TMPRSS3 HS3ST3A1 EPN1	1.14e-05	191	126	8	5607_DN
Drug	Butoconazole nitrate [32872-77-1]; Down 200; 8.4uM; MCF7; HT_HG-U133A	MYCL ZBTB7A SLC16A3 PCSK7 BAIAP2 PATJ PLXNB1 RAB11FIP3	1.33e-05	195	126	8	3288_DN
Drug	AC1N4HBY	ACACA GLUD1 GLUD2	1.36e-05	9	126	3	CID004128835
Drug	Flutamide [13311-84-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A	ZNF423 SERPINF1 ASAP3 ARHGEF17 SOX13 SLC16A3 CACNA1H PATJ	1.43e-05	197	126	8	3885_DN
Drug	Carbarsone [121-59-5]; Down 200; 15.4uM; MCF7; HT_HG-U133A	RALGDS PDE3B ZZEF1 ZBTB7A FASTK BAIAP2 PLXNB1 RAB11FIP3	1.43e-05	197	126	8	3250_DN
Drug	phenyltriethoxysilane	GLUD1 GLUD2	3.04e-05	2	126	2	CID000013075
Drug	G-3SH	GLUD1 GLUD2	3.04e-05	2	126	2	CID000174237
Drug	iodoacetyldiethylstilbestrol	GLUD1 GLUD2	3.04e-05	2	126	2	CID006455327
Drug	methylmercuric bromide	GLUD1 GLUD2	3.04e-05	2	126	2	CID000068175
Drug	5-methylisophthalate	GLUD1 GLUD2	3.04e-05	2	126	2	CID000068137
Drug	Uc39	ACACA FASN	3.04e-05	2	126	2	CID003000889
Drug	x 1 s	GLUD1 GLUD2	3.04e-05	2	126	2	CID000409694
Drug	butanetetracarboxylic acid	GLUD1 GLUD2 TNXB	4.55e-05	13	126	3	CID000015560
Drug	Tdagp	OPRK1 GLUD1 GLUD2	5.76e-05	14	126	3	CID005491936
Drug	AC1Q68ZE	TEAD2 ACACA FASN GLUD1 GLUD2	7.78e-05	79	126	5	CID000000265
Drug	Methoxy-6-harmalan [3589-73-9]; Up 200; 18.6uM; MCF7; HT_HG-U133A	PRUNE2 GPR6 PDE3B SERPINF1 ZZEF1 ZBTB7A PCSK6	8.93e-05	189	126	7	5455_UP
Drug	N-piperidinyl-(8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydrobenzo(6,7)cyclohepta(1,2-c)pyrazole-3-carboxamide)	ACACA FASN	9.08e-05	3	126	2	ctd:C475771
Drug	lenthionine	GLUD1 GLUD2	9.08e-05	3	126	2	CID000067521
Drug	mildiomycin	GLUD1 GLUD2	9.08e-05	3	126	2	CID000125665
Drug	methoxyethylmercury	GLUD1 GLUD2	9.08e-05	3	126	2	CID000115155
Drug	4-methylumbelliferyl laurate	GLUD1 GLUD2	9.08e-05	3	126	2	CID000600674
Drug	methylmercuric iodide	GLUD1 GLUD2	9.08e-05	3	126	2	CID000067347
Drug	Equilin [474-86-2]; Down 200; 15uM; MCF7; HT_HG-U133A	SERPINF1 PACSIN3 ARHGEF17 SOX13 CEP250 BAIAP2 RAB11FIP3	1.05e-04	194	126	7	5255_DN
Drug	haloperidol; Up 200; 10uM; MCF7; HT_HG-U133A	MYCL RALGDS SOX13 TMPRSS3 CACNA1H BAIAP2 RAB11FIP3	1.05e-04	194	126	7	1628_UP
Drug	Dt6	OPRK1 GLUD1 GLUD2	1.06e-04	17	126	3	CID009549241
Drug	Piribedil hydrochloride [78213-63-5]; Down 200; 12uM; MCF7; HT_HG-U133A	ZNF444 PDE3B SOX13 ZBTB7A PCSK7 BAIAP2 PATJ	1.09e-04	195	126	7	3512_DN
Drug	Quinidine hydrochloride monohydrate [6151-40-2]; Down 200; 10.6uM; MCF7; HT_HG-U133A	PDE3B ZBTB7A TMPRSS3 DZIP3 PCSK7 BAIAP2 PATJ	1.09e-04	195	126	7	3191_DN
Drug	Amiodarone hydrochloride [19774-82-4]; Down 200; 5.8uM; MCF7; HT_HG-U133A	MYCL ZNF444 ZBTB7A SLC16A3 PCSK6 CACNA1H RAB11FIP3	1.12e-04	196	126	7	3296_DN
Drug	16-phenyl tetranor Prostaglandin E2; Down 200; 10uM; MCF7; HT_HG-U133A	PDE3B HIVEP2 ZBTB7A SLC16A3 CEP250 ZFHX2 ZNF646	1.12e-04	196	126	7	7541_DN
Drug	Atractyloside potassium salt [102130-43-8]; Up 200; 5uM; MCF7; HT_HG-U133A	ZNF444 HIVEP2 ASAP3 ARHGEF17 CEP250 PCSK6 ZFHX2	1.12e-04	196	126	7	3435_UP
Drug	Methiazole; Up 200; 15uM; PC3; HT_HG-U133A	PDE3B TBKBP1 GPR88 ARHGEF17 ZBTB7A FASN TMPRSS3	1.12e-04	196	126	7	3796_UP
Drug	Fluoxetine hydrochloride [59333-67-4]; Up 200; 11.6uM; MCF7; HT_HG-U133A	PPP1R9A ARHGEF17 PCSK6 CACNA1H BAIAP2 ROBO3 RAB11FIP3	1.12e-04	196	126	7	3314_UP
Drug	Quipazine dimaleate salt [4774-24-7]; Up 200; 9uM; MCF7; HT_HG-U133A	MYCL PPP1R9A ASAP3 ZZEF1 ARHGEF17 MINDY2 CACNA1H	1.16e-04	197	126	7	2782_UP
Drug	CP-944629 [668990-94-1]; Up 200; 10uM; MCF7; HT_HG-U133A	RALGDS ZNF444 BFSP1 SLC16A3 CACNA1H BAIAP2 RAB11FIP3	1.19e-04	198	126	7	7497_UP
Drug	Etofylline [519-37-9]; Down 200; 17.8uM; MCF7; HT_HG-U133A	ZNF444 PACSIN3 ZBTB7A SLC16A3 FASTK CEP250 HS3ST3A1	1.19e-04	198	126	7	5467_DN
Drug	Amitryptiline hydrochloride [549-18-8]; Up 200; 12.8uM; MCF7; HT_HG-U133A	PRUNE2 PCSK5 MINDY2 OPRK1 PCSK6 BAIAP2 ROBO3	1.19e-04	198	126	7	5453_UP
Drug	aspirin, USP; Up 200; 100uM; PC3; HT_HG-U133A	MYCL TBKBP1 ZNF423 ARHGEF17 PCSK6 EPN1 ZNF646	1.19e-04	198	126	7	4428_UP
Drug	Oxaprozin [21256-18-8]; Down 200; 13.6uM; MCF7; HT_HG-U133A	PDE3B ASAP3 SLC22A18AS ZBTB7A DZIP3 CACNA1H ROBO3	1.23e-04	199	126	7	4352_DN
Drug	Sulindac [38194-50-2]; Up 200; 11.2uM; PC3; HT_HG-U133A	TBKBP1 ZZEF1 MINDY2 ZBTB7A DZIP3 ZFHX2 RAB11FIP3	1.23e-04	199	126	7	5103_UP
Drug	Clofilium tosylate [92953-10-1]; Down 200; 7.8uM; MCF7; HT_HG-U133A	PDE3B BICRA SLC22A18AS PCSK6 TMPRSS3 PLXNB1 RAB11FIP3	1.23e-04	199	126	7	6830_DN
Drug	Moroxidine hydrochloride [3160-91-6]; Down 200; 19.2uM; HL60; HG-U133A	PDE3B ACACA ZZEF1 ARHGEF15 ZBTB7A FASTK PCSK7	1.27e-04	200	126	7	2027_DN
Drug	glicentin	PCSK1 PCSK5 HTR7 PCSK6	1.56e-04	49	126	4	CID000126332
Drug	methyl benzoquate	GLUD1 GLUD2	1.81e-04	4	126	2	CID000026383
Drug	pentenoic acid	GLUD1 GLUD2	1.81e-04	4	126	2	CID000012299
Drug	AC1Q4I5I	CELA3B CELA3A	1.81e-04	4	126	2	CID000194288
Drug	L-659-699	ACACA FASN	1.81e-04	4	126	2	CID006440895
Drug	alpha-ketoglutaramate	GLUD1 GLUD2	1.81e-04	4	126	2	CID000000048
Drug	ureidoglycine	GLUD1 GLUD2	1.81e-04	4	126	2	CID000439649
Drug	Ivin	GLUD1 GLUD2	1.81e-04	4	126	2	CID000014083
Drug	8-BDB-TADP	GLUD1 GLUD2	1.81e-04	4	126	2	CID000130791
Drug	cadina-3,9-diene	GLUD1 GLUD2	1.81e-04	4	126	2	CID000010657
Drug	AC1L9CUQ	GLUD1 GLUD2	1.81e-04	4	126	2	CID000442451
Drug	curcumene	FASN PCSK7	1.81e-04	4	126	2	CID000092139
Drug	luxabendazole	GLUD1 GLUD2	1.81e-04	4	126	2	CID000072019
Drug	N-butylmaleimide	GLUD1 GLUD2	1.81e-04	4	126	2	CID000239780
Drug	alpha-methylglutamate	GLUD1 GLUD2	1.81e-04	4	126	2	CID000095440
Drug	2b E2	GLUD1 GLUD2	1.81e-04	4	126	2	CID005327076
Disease	Alzheimer's disease (implicated_via_orthology)	HIVEP2 SERPINF1 SOX13 TM2D1 NOTCH4	4.08e-06	57	123	5	DOID:10652 (implicated_via_orthology)
Disease	fascioliasis (biomarker_via_orthology)	GLUD1 GLUD2	5.16e-05	3	123	2	DOID:885 (biomarker_via_orthology)
Disease	muscular disease (implicated_via_orthology)	ACACA FASN	1.71e-04	5	123	2	DOID:0080000 (implicated_via_orthology)
Disease	childhood absence epilepsy (biomarker_via_orthology)	GLUD1 GLUD2	2.56e-04	6	123	2	DOID:1825 (biomarker_via_orthology)
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	PCSK1 SERPINF1 REG3G CRHR1 ADRA2A	3.86e-04	147	123	5	DOID:9352 (biomarker_via_orthology)
Disease	irritable bowel syndrome (biomarker_via_orthology)	HTR7 CRHR1	4.75e-04	8	123	2	DOID:9778 (biomarker_via_orthology)
Disease	visual epilepsy (biomarker_via_orthology)	PCSK1 REG3G GLUD1 GLUD2	5.57e-04	90	123	4	DOID:11832 (biomarker_via_orthology)
Disease	ubiquitin-conjugating enzyme E2 G2 measurement	TNXB NOTCH4	7.59e-04	10	123	2	EFO_0022035
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	PCSK1 SCYL1 IQCN ZZEF1 TNRC6A BAIAP2 PATJ	8.57e-04	364	123	7	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	hepatic encephalopathy (biomarker_via_orthology)	GLUD1 GLUD2	1.75e-03	15	123	2	DOID:13413 (biomarker_via_orthology)
Disease	endoplasmic reticulum resident protein 29 measurement	TNXB NOTCH4	1.99e-03	16	123	2	EFO_0020346
Disease	obesity (implicated_via_orthology)	PCSK1 SEC16A ZFHX2 PLXNB1 NOTCH4	2.11e-03	215	123	5	DOID:9970 (implicated_via_orthology)
Disease	X-11470 measurement	TNXB NOTCH4	2.81e-03	19	123	2	EFO_0021241
Disease	attention deficit hyperactivity disorder (is_implicated_in)	ADRA2A BAIAP2	3.12e-03	20	123	2	DOID:1094 (is_implicated_in)
Disease	anxiety disorder (implicated_via_orthology)	HTR7 ADRA2A	3.77e-03	22	123	2	DOID:2030 (implicated_via_orthology)
Disease	autism spectrum disorder symptom	SLC22A18AS PATJ	4.12e-03	23	123	2	EFO_0005426

Protein segments in the cluster

Peptide	Gene	Start	Entry
DADGAGSPSDWASPL	TBC1D12	181	O60347
PPGGWDDSHLDSAGR	SLC33A1	31	O00400
GGEWSPSLDGLDPQA	CCAR2	361	Q8N163
FLGEPSAGPGSWGSA	ASAP3	401	Q8TDY4
EEAGPPAAGEDEASW	CSPG5	61	O95196
PAAGEDEASWTAPGG	CSPG5	66	O95196
DEASWTAPGGELAGP	CSPG5	71	O95196
PGSPGADWGFQDTAN	CREB3L3	396	Q68CJ9
GPGAETAAAPVWEEA	NT5C1A	16	Q9BXI3
SGPWEDEGAEDGAPG	BLOC1S4	41	Q9NUP1
DWAKPSFVADGPGEA	ARSI	21	Q5FYB1
AGGDGEDDGPVWIPS	ALPK3	221	Q96L96
ARFPGGPAAAAWAGD	ABCB10	116	Q9NRK6
GVSPWGDSPIDFEDS	ACACA	481	Q13085
WGVGEDGSPSPANAG	ARHGEF15	366	O94989
DGPAGSAASIWPAEG	SLC22A18AS	116	Q8N1D0
SGNDAPPGGSKETWG	CCER1	231	Q8TC90
EDGDWTEPGAPGGTE	ARMCX6	71	Q7L4S7
EPDGVEDTGAWGGVS	CCDC27	346	Q2M243
DPDGSGSPATWDNFG	PPM1K	51	Q8N3J5
ADGEGAAVAPEPESW	RAB44	26	Q7Z6P3
GQEPEWATAGAGAPG	RILP	206	Q96NA2
DEPAPGAAADGGARW	RAB11FIP3	56	O75154
DTGPADAGVVGGQSW	IQCN	871	Q9H0B3
DGSDAPPGSPDWAGD	ARHGEF17	611	Q96PE2
LAGSNDDTWDPGSPV	ANKRD34B	216	A5PLL1
AGASAGASQGPWEDD	ANO7	681	Q6IWH7
TEGATCAGPGESWSP	FASTK	16	Q14296
TGSAEPPADWDGAGG	GPR88	96	Q9GZN0
PDTGEWGPPAAAALG	GPR6	31	P46095
QECAVSWAGPPGDFG	MAGI3	16	Q5TCQ9
GPLWGTNGDGDETAE	GIGYF1	376	O75420
ASEKGSGDGPWPEPE	HDGFL1	96	Q5TGJ6
SGDGPWPEPEAAEGD	HDGFL1	101	Q5TGJ6
CPWEASEGGEDGKPA	GPR179	1381	Q6PRD1
EAVGPWESVDPGSFS	GPR179	1646	Q6PRD1
CPWEAGGGAAEEGEQ	GPR179	2131	Q6PRD1
VDEGPTGVKAPDGGW	SLC16A3	6	O15427
GDLWGGNVAEDSSGP	FN3KRP	216	Q9HA64
DGDPGGPWCHTTDPA	MST1L	131	Q2TV78
PPWEGADAGAAGGEA	LMTK3	1251	Q96Q04
SPEANPASGEEGWKG	DCLK3	186	Q9C098
SWGPDDDGKTVDGPA	PCSK5	271	Q92824
WGPDDDGKTVDGPGR	PCSK6	306	P29122
CSWGPDDDGKTVDGP	PCSK7	286	Q16549
GGELPEADEWTGGDA	PLXNB1	846	O43157
PGGSAETTEAEWGPA	LENG9	286	Q96B70
GADDWGSDTEEGPSP	PDCD2L	126	Q9BRP1
WGDGDAGSAAPHTPP	PDE3B	176	Q13370
PFWDSGEPRAGEKGA	NRDE2	521	Q9H7Z3
PEGGPLEGAAWAGSS	KIF26A	1091	Q9ULI4
AAWEEESPGLSGGPG	HS3ST3A1	111	Q9Y663
AGTEGDAQEWPGAGS	MED17	61	Q9NVC6
PQGDTAGESSWGSGP	IRAK1	621	P51617
AAPGASPSPGGDAAW	MSH6	36	P52701
SPSPGGDAAWSEAGP	MSH6	41	P52701
PWAGDKGGAASPAAT	MSL1	151	Q68DK7
SQGPATWEGASNPDE	DZIP3	1126	Q86Y13
DPSEEWGSGDPEAEG	NPAS4	721	Q8IUM7
NGEAPGAEPAPSAWA	KLRG2	106	A4D1S0
TDGQDGPTEAAGAWV	GLYCTK	451	Q8IVS8
GWGAGASAPVEDDSD	AVEN	81	Q9NQS1
DSGGPLNCPTEDGGW	CELA3A	216	P09093
GESDGSIWNPDGIDP	GLUD1	331	P00367
EPERPADEGWAGATS	BFSP1	26	Q12934
ASAAEGSRGDWPPAD	CPAMD8	1526	Q8IZJ3
PELSGGGDSAPSVWG	CEP250	1201	Q9BV73
GGDSAPSVWGLEPDQ	CEP250	1206	Q9BV73
LEDEGWAAAAPSPGS	CDC42EP4	281	Q9H3Q1
SSSAPGQGPEADGQW	DIDO1	2051	Q9BTC0
DSGGPLNCPTEDGGW	CELA3B	216	P08861
DGALEVGAPWSGAPF	CRHR1	156	P34998
QAWAAGPGAGPETAG	FIZ1	261	Q96SL8
WAEAAGPAGGAEPLF	RALGDS	6	Q12967
LTPDEDGSPNWDGNS	ITIH6	1031	Q6UXX5
AAGEGPTPDPWGSSD	EPN1	341	Q9Y6I3
ADGSCAGGEPSPWQD	KLHDC7A	176	Q5VTJ3
EGPWADGGSGEPAHA	FIGLA	171	Q6QHK4
AWDVPAAEDFPNGSG	FASN	841	P49327
PAASAAQGTGDPDWE	BICRA	1451	Q9NZM4
GSGEPGEAKAWGPEA	CACNA1H	2161	O95180
GEAKAWGPEAEPALG	CACNA1H	2166	O95180
GESDGSIWNPDGIDP	GLUD2	331	P49448
SPGSPGTGQDEEWSD	PACSIN3	341	Q9UKS6
LHDPTQGSEPDGDGW	REG3G	106	Q6UW15
PGWAEPDSNGSAGSE	OPRK1	31	P41145
AAGDGPGVWAAETSG	MINDY2	36	Q8NBR6
GSSPGGPEEWPDAKD	RASL10A	66	Q92737
AWSVAGNASDGEPPE	RAB11FIP1	841	Q6WKZ4
SGGSTPDRGHDWGAP	SUSD2	381	Q9UGT4
VHGSQAWTPPADGEG	TRIM44	61	Q96DX7
AWTPPADGEGAGKEE	TRIM44	66	Q96DX7
VGDPSLDARDSGPGW	PRUNE2	2641	Q8WUY3
DDCFEADGGFGPWSP	SSPOP	3806	A2VEC9
NWGGPESSDKGDPFA	SCYL1	726	Q96KG9
DDPAGSAGETPGWLS	SLC18B1	16	Q6NT16
DGGPDAEGVWSPDIE	TEAD2	36	Q15562
GSDWGCADTSAPEPA	RNF217	56	Q8TC41
GNWDGGDCSLGVPDP	NOTCH4	1196	Q99466
AASGGWAAPQDAPEA	FAM110D	131	Q8TAY7
AGAGEDADWLEGGSP	SLX4	871	Q8IY92
LSPDGGADPVAGSWA	HTR7	31	P34969
GVTGPDGEDYSPWAD	BAIAP2	301	Q9UQB8
PDAGNASWNGTEAPG	ADRA2A	21	P08913
SGWGATEDGAGDASP	TMPRSS3	341	P57727
EEDGATAEGEGAPWP	SHF	171	Q7M4L6
GSWDCSSPEGNGSPE	SOX13	71	Q9UN79
EELWGPAASPDGSSA	ZNF444	96	Q8N0Y2
WCLGGTDPEGEGPAE	ZBP1	66	Q9H171
KESPVAAGEAGPDWF	ZFHX2	361	Q9C0A1
ADPEDTVGGHPSWSG	TDRP	121	Q86YL5
PEPWPGGCTGDEAES	MYCL	61	P12524
GFEWNEDGAGTTPSP	SERPINF1	361	P36955
PEALTAPSGGQWGAE	RNF208	216	Q9H0X6
DSEAPPGWDRADSGP	SEC16A	2061	O15027
EGEGEETPNFSHWGP	PATJ	1051	Q8NI35
SFPSTDSGGGAWEPA	PLEKHG4B	636	Q96PX9
DSGGGAWEPAQPLSG	PLEKHG4B	641	Q96PX9
APPEWSQGDSGAKGG	ROBO3	1051	Q96MS0
DWAAPLDPGGASACS	TEDC1	276	Q86SX3
GWGGPTCSDPTDAEI	TNXB	161	P22105
AASSEAPEPLSWGAG	ZNF646	1446	O15015
GPWGAVATSAGGEES	TM2D1	31	Q9BX74
GAGEPTVPEGAIWEG	TACC2	676	O95359
EAPGEHGLAPWEQGS	ARHGAP8	416	P85298
GADSWPPAAENSFPG	ZNF469	231	Q96JG9
SAGKAAGSPGDPWGQ	ZNF469	3216	Q96JG9
AGSPGDPWGQEGEAK	ZNF469	3221	Q96JG9
VGDVPGTWGPDDSDS	ZNF316	276	A6NFI3
DDSDSAQTPEGWGPD	ZNF316	286	A6NFI3
DEAAAAGGEGWGPHQ	ZZEF1	11	O43149
PGDGDDDPQLSWVAS	ZNF423	91	Q2M1K9
SDGLSLAAPGWGVPE	PSMB5	36	P28074
VSPEWAPPGDGAESG	HIVEP2	846	P31629
EVWLDSPGDPSLGGD	TBKBP1	21	A7MCY6
DSGPSWGEPIAAASS	TNRC6A	1086	Q8NDV7
TGDGDEGDSNPGLWP	ZBTB7A	231	O95365
AGGSEPQDEWGGSKS	PPP1R9A	166	Q9ULJ8
ASWGPNDDGKTVEGP	PCSK1	266	P29120