Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
HumanPhenoFocal impaired awareness seizure

VPS11 TSC2 POGZ TBK1

6.68e-05126104HP:0002384
HumanPhenoAbnormal response to social norms

IL1RAPL1 TSC2 POGZ DENND5A POLE TBK1 RTTN

1.89e-04807107HP:5200123
HumanPhenoSocial disinhibition

IL1RAPL1 TSC2 POGZ DENND5A POLE TBK1 RTTN

1.89e-04807107HP:5200029
HumanPhenoDisinhibition

IL1RAPL1 TSC2 POGZ DENND5A POLE TBK1 RTTN

1.89e-04807107HP:0000734
HumanPhenoInappropriate behavior

IL1RAPL1 TSC2 POGZ DENND5A POLE TBK1 RTTN

1.89e-04807107HP:0000719
DomainARM-type_fold

PPP4R3B VPS11 TSC2 MROH2A RTTN EFR3A

2.50e-05339336IPR016024
Domain-

AGO4 POLQ POLE

7.73e-05473333.30.420.10
DomainARM-like

PPP4R3B TSC2 MROH2A RTTN EFR3A

1.04e-04270335IPR011989
DomainRNaseH-like_dom

AGO4 POLQ POLE

2.43e-0469333IPR012337
Domain-

PDZRN3 PDZRN4

2.72e-04143323.90.890.10
DomainSIAH-type

PDZRN3 PDZRN4

3.58e-0416332IPR013323
DomainTRAF-like

PDZRN3 PDZRN4

8.15e-0424332IPR008974
Domain-

VPS11 SPAG9 RMC1 SEMA7A

2.70e-033333342.130.10.10
DomainWD40/YVTN_repeat-like_dom

VPS11 SPAG9 RMC1 SEMA7A

2.76e-03335334IPR015943
Domain-

TSC2 RTTN EFR3A

6.95e-032223331.25.10.10
DomainZINC_PROTEASE

ADAMTS16 ACE

1.29e-0298332PS00142
DomainZF_RING_1

VPS11 PDZRN3 PDZRN4

1.45e-02291333PS00518
DomainWD40_repeat_dom

VPS11 SPAG9 RMC1

1.53e-02297333IPR017986
DomainZF_RING_2

VPS11 PDZRN3 PDZRN4

1.54e-02298333PS50089
Pubmed

Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase.

TSC2 CBX4 PDZRN3 PDZRN4

3.57e-076034422889411
Pubmed

Identification and characterization of PDZRN3 and PDZRN4 genes in silico.

PDZRN3 PDZRN4

2.78e-06334215010864
Pubmed

ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation.

ZSWIM8 SPAG9

9.26e-06534234686700
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ZSWIM8 CLSTN2 POGZ CBX4 PIP4K2C FEZF2 PDZRN3 TBK1

9.47e-06111634831753913
Pubmed

ACE variants and risk of intracerebral hemorrhage recurrence in amyloid angiopathy.

CPB2 ACE

2.59e-05834220381197
Pubmed

Gene polymorphisms related to angiogenesis, inflammation and thrombosis that influence risk for oral cancer.

CPB2 ACE

3.33e-05934218674955
Pubmed

TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.

TSC2 TBK1

8.38e-051434228716898
Pubmed

Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling.

CLSTN2 PDZRN3

1.25e-041734215511637
Pubmed

Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes.

POGZ FEZF2

1.25e-041734234879283
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

PPP4R3B ZSWIM8 CBX4 PIP4K2C TBK1

2.52e-0458834538580884
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

TSC2 POGZ CBX4 YLPM1

3.34e-0434134432971831
Pubmed

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.

ZSWIM8 VPS11 POLE

4.02e-0414734329576527
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

ZSWIM8 SPAG9 POGZ POLE YLPM1

4.07e-0465334522586326
Pubmed

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.

TSC2 PIP4K2C TBK1

4.27e-0415034332423001
Pubmed

The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.

CBX4 BMP2K

4.81e-043334219336002
Pubmed

The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.

VPS11 TSC2

4.81e-043334233452816
Pubmed

Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.

PDZRN3 PDZRN4

5.10e-043434230726710
Pubmed

Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.

PDZRN3 PDZRN4

5.72e-043634226053890
Pubmed

Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.

ZSWIM8 SPAG9 TBK1

5.83e-0416734325659891
Pubmed

Tissue-Specific Actions of Pax6 on Proliferation and Differentiation Balance in Developing Forebrain Are Foxg1 Dependent.

FEZF2 PDZRN3

6.72e-043934230529950
Pubmed

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.

CBX4 YLPM1

8.55e-044434227505670
Pubmed

Gender differences in genetic risk profiles for cardiovascular disease.

CPB2 ACE

9.35e-044634218974842
GeneFamilyDNA polymerases

POLQ POLE

4.56e-0423252535
GeneFamilyRing finger proteins

VPS11 PDZRN3 PDZRN4

6.25e-0327525358
GeneFamilyPDZ domain containing

PDZRN3 PDZRN4

1.86e-021522521220
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

TSC2 YLPM1

2.57e-02181252694
GeneFamilyImmunoglobulin like domain containing

IL1RAPL1 SEMA7A

2.90e-02193252594
CoexpressionGSE3982_MAC_VS_TH1_UP

SPAG9 DENND5A AGO4 ACE BMP2K EFR3A

2.00e-07199346M5510
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS16 PLCXD3 ST8SIA1 PDZRN4

5.65e-061543441e32969bee810adaf2d560f0824a16227df513d8
ToppCell343B-Myeloid-Mast_cell-|343B / Donor, Lineage, Cell class and subclass (all cells)

IL1RAPL1 ST8SIA1 SEMA7A BMP2K

6.57e-06160344a2f09b5955602819c8978f4372130c8ef915cd07
ToppCell343B-Myeloid-Mast_cell|343B / Donor, Lineage, Cell class and subclass (all cells)

IL1RAPL1 ST8SIA1 SEMA7A BMP2K

6.57e-06160344133ecae0a894d9a0d49d58859623359096b6f030
ToppCell368C-Myeloid-Mast_cell|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

IL1RAPL1 ST8SIA1 SEMA7A BMP2K

8.95e-061733448cffb4a37d30b6626188309b868ac4a62e91262f
ToppCell368C-Myeloid-Mast_cell-|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

IL1RAPL1 ST8SIA1 SEMA7A BMP2K

8.95e-06173344fb87ea74bf70aa83b458edf728c81857c8b8eb96
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PLCXD3 CLSTN2 ST8SIA1 FEZF2

1.05e-051803448923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ADAMTS16 IL1RAPL1 ST8SIA1 PDZRN3

1.32e-05191344fa380a8752de158974b2ae5e741573439719cc0d
ToppCellcellseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

IL1RAPL1 ST8SIA1 SEMA7A BMP2K

1.35e-05192344b29d6b4bed4d55060586276973732461538752df
ToppCellNeuronal-Excitatory-eG(DAPK2)-|Neuronal / cells hierarchy compared to all cells using T-Statistic

PLCXD3 CLSTN2 ST8SIA1 FEZF2

1.58e-052003447cea58e2691564e653cc972bf5aaff2df1f2666e
ToppCellParenchymal-10x5prime-Immune_Myeloid-Mast_cell-Mast_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IL1RAPL1 ST8SIA1 SEMA7A BMP2K

1.58e-052003448943278190f42016ee914e584d1b6b9aeaf7c73f
ToppCellNeuronal-Excitatory-eG(DAPK2)--|Neuronal / cells hierarchy compared to all cells using T-Statistic

PLCXD3 CLSTN2 ST8SIA1 FEZF2

1.58e-05200344193c42c31a366a60d80c4c1fc6a1592a5b01a3ad
ToppCellNeuronal-Excitatory-eG(DAPK2)---|Neuronal / cells hierarchy compared to all cells using T-Statistic

PLCXD3 CLSTN2 ST8SIA1 FEZF2

1.58e-052003447c780e995a5fc3793080da61b6bf7a12880e9df8
ToppCellNeuronal-Excitatory-eG(DAPK2)----L4-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

PLCXD3 CLSTN2 ST8SIA1 FEZF2

1.58e-05200344d0b31dc5eedc0635c0d7ceabaa6202386cf2a4a4
ToppCellNeuronal-Excitatory-eC(RORB)-eC_2-C1R-|Neuronal / cells hierarchy compared to all cells using T-Statistic

ADAMTS16 PLCXD3 CLSTN2 PDZRN4

1.58e-05200344891a80cbde575f81f3466217175f41e1d4f66d5e
ToppCellNeuronal-Excitatory-eG(DAPK2)|Neuronal / cells hierarchy compared to all cells using T-Statistic

PLCXD3 CLSTN2 ST8SIA1 FEZF2

1.58e-052003448444ae3c10b1152dec67ca812e6c417cc3b9cf89
ToppCellNeuronal-Excitatory-eC(RORB)-eC_2-C1R|Neuronal / cells hierarchy compared to all cells using T-Statistic

ADAMTS16 PLCXD3 CLSTN2 PDZRN4

1.58e-05200344c761d1742653a83e69e4c03d6e10e5e53f28bebb
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLCXD3 CLSTN2 PDZRN3 PDZRN4

1.58e-0520034474e74123ea7bf38d337a3a0248a6a51437c6ab42
ToppCellNeuronal-Excitatory-eC(RORB)-eC_2-C1R--L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

ADAMTS16 PLCXD3 CLSTN2 PDZRN4

1.58e-05200344dcbc91ed3351bafd72cf71d7025cbbdc8361d9b9
ToppCellParenchymal-10x5prime-Immune_Myeloid-Mast_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IL1RAPL1 ST8SIA1 SEMA7A BMP2K

1.58e-05200344ea52df18400550b65de142d03b3b0963436e03d9
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Nxph2_Wls|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PLCXD3 FEZF2 EFR3A

1.32e-0413034305d5a73acf1d7f75a79876b1a06d27c74a89b8a4
ToppCellLV-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

PLCXD3 CBX4 PDZRN3

1.32e-04130343a3e12984fb61311e49cc76c59f74f4dffc48faa1
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ST8SIA1 FEZF2 EFR3A

1.79e-0414434308005be9e3367f78ef27e125d9cce5ca53f4bd2d
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_VISp_Trhr_Met|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FEZF2 PDZRN3 EFR3A

1.82e-041453438abbc781f5f69f039617c29a5589d7b6950c2c40
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_VISp_Trhr_Cpne7|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FEZF2 PDZRN3 EFR3A

1.98e-041493438638b3819193d11411df58964069fec583f617f4
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-NP|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PLCXD3 FEZF2 EFR3A

2.01e-041503432ba55e51877e2e749cccdae7df5d885dc55b2587
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Krt80_Sla|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PLCXD3 FEZF2 PDZRN4

2.05e-04151343f50c5ae9dae507df750df25e151b58685fec70ce
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-NP|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FEZF2 PDZRN3 EFR3A

2.09e-04152343b6a7453fbf9f898e4f222b215907c9a110baa2f6
ToppCell368C-Myeloid-Mast_cell|368C / Donor, Lineage, Cell class and subclass (all cells)

IL1RAPL1 SEMA7A BMP2K

2.09e-04152343faf30245a1690aaa27c7be0832797c340e4af4d7
ToppCell368C-Myeloid-Mast_cell-|368C / Donor, Lineage, Cell class and subclass (all cells)

IL1RAPL1 SEMA7A BMP2K

2.09e-04152343519c9ed05fdaf420e42147ffae1dc05a7f86fdd4
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Adamts2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTS16 PDZRN3 PDZRN4

2.26e-041563432cd007b423c2395c5ce331902e7f27c805755eb3
ToppCellAdult-Mesenchymal-myofibroblast_cell-D122|Adult / Lineage, Cell type, age group and donor

IL1RAPL1 POLQ PDZRN3

2.35e-04158343410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A5 MROH2A PDZRN4

2.44e-04160343c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

IL1RAPL1 PDZRN3 PDZRN4

2.44e-04160343fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A5 MROH2A PDZRN4

2.44e-0416034325c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L5_RORB_SNHG7|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS16 CLSTN2 FEZF2

2.57e-041633436ed2a71385e85508ed513282c06440add7cc010c
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_OR1J1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS16 PLCXD3 PDZRN4

2.67e-041653431f88f6939f88b80a0c98b4eef3684ba03c64ff7c
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ST8SIA1 SEMA7A BMP2K

2.67e-04165343c39f0479955c4e23921f7a450d3bc251a002200f
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

PLCXD3 PDZRN3 PDZRN4

2.76e-041673435c82d801e3b7d7c6c967a73b94b2ee2a8da1fd6e
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPB2 ST8SIA1 ACE

2.76e-04167343ed7e785dcd25777f64e0c2596ada4f5a5ea17121
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POLQ POLE MROH2A

2.81e-04168343a7eb28e15b591997f1aee09501cb20ae18beca08
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS16 CLSTN2 PDZRN4

2.81e-041683431d58731a481ecac84c15affa84f8041dd67d944c
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 FEZF2 PDZRN4

2.81e-041683437abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)--|Striatum / BrainAtlas - Mouse McCarroll V32

VPS11 PLCXD3 DENND5A

2.86e-041693435375eb52ebadccb7bfff997a11985f23e81014d6
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)|Striatum / BrainAtlas - Mouse McCarroll V32

VPS11 PLCXD3 DENND5A

2.86e-04169343c3bf0cb67f200d02d5a021754e9b2a68d23ea168
ToppCelldroplet-Kidney-nan-18m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPB2 ST8SIA1 ACE

2.86e-04169343f00741203efa0b948db7223ee8c19bdd0918258a
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)-|Striatum / BrainAtlas - Mouse McCarroll V32

VPS11 PLCXD3 DENND5A

2.86e-041693431c132d21255f5a5174ac38db4e91927f9093418e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5_RORB_LINC01202|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS16 CLSTN2 PDZRN4

2.91e-0417034387cac555f16b6c2ef3d1b3a00f992d8bf2237b50
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 FEZF2 PDZRN4

2.91e-04170343417b77c12a7982b1ce4b4bc57f30335d261220f5
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IL1RAPL1 PDZRN3 PDZRN4

2.96e-041713434ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS16 CLSTN2 PDZRN4

2.96e-041713439d5cabd71a901a00eb16c4d151189296f1b3bf6f
ToppCelldroplet-Kidney-nan-21m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPB2 ST8SIA1 ACE

2.96e-041713438e7223ba447947cdf4e1c82a52fd90439cf3d8f6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5-6_RORB_LINC00320|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS16 CLSTN2 PDZRN4

3.06e-041733434ec147479b359cce1975d57a50ee1437a0e1e663
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 ST8SIA1 FEZF2

3.06e-04173343ee972d9cc68755926512fd3bbe1267098c67cd94
ToppCell3'_v3-bone_marrow-Lymphocytic_B-GC_B_(I)|bone_marrow / Manually curated celltypes from each tissue

POLE STRIP1 RTTN

3.06e-0417334367f0f0bf88eab69987b71d96b864ed2b14975adb
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-Mast_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ST8SIA1 BMP2K FEZF2

3.06e-04173343a7dee23b1d43d3070d502487af319ff81a9a747b
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 FEZF2 PDZRN4

3.11e-04174343e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CD24|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS16 CLSTN2 PDZRN4

3.11e-041743433e29d620b7b4ab1915ddac70ee5a50d09072292b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 FEZF2 PDZRN4

3.17e-0417534390e29945aa861082c94bb4f331161adc3a6ef899
ToppCell367C-Myeloid-Dendritic-cDC_proliferating_2|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

CPB2 CBX4 POLQ

3.17e-04175343bde785ff0c854646d7ab8571359e9d69a7bf013f
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 FEZF2 PDZRN4

3.22e-0417634372a2a01618ce836bc843395d5095e9090759b4a6
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 FEZF2 PDZRN4

3.22e-04176343e4b21fd6a5e0c5950f27c3e1868318e48330ae5e
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS16 CLSTN2 PDZRN4

3.27e-04177343921783ed0fe20294d2f384d9136924b679df01bb
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 FEZF2 PDZRN4

3.27e-04177343bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5_RORB_LINC01202|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS16 PLCXD3 PDZRN4

3.27e-04177343b6476a91abd06b8271b4d0ad7431d24b44022b47
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 ST8SIA1 FEZF2

3.27e-041773437e799333307448c6a94d1f33dbc59c543336f45e
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 FEZF2 PDZRN4

3.27e-041773434c069f0d044a96118090b85ca592a21d6b5d9399
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 FEZF2 PDZRN4

3.33e-04178343431e7557b8e8764e16e9e48368ce6bfa3c61561a
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPAG9 CLSTN2 DENND5A

3.33e-04178343a0ab20c588e7d43d0320d4779d9ab95c1c86e297
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A5 CPB2 CLSTN2

3.33e-0417834330ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS16 PLCXD3 PDZRN3

3.38e-041793438766a5a066091879f521acfc612abf563ff78808
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 ST8SIA1 FEZF2

3.38e-04179343c815eb9f760fe4ca7a5e49beb224659f0b864f22
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS16 CLSTN2 PDZRN4

3.38e-04179343445eeb0356d9fd894aa33dd9f45d893b21424149
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 FEZF2 PDZRN4

3.38e-041793437954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCell3'-Broncho-tracheal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IL1RAPL1 ST8SIA1 BMP2K

3.38e-0417934340441de2d679733ecbf2145fabc3ed65a53310eb
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 FEZF2 PDZRN4

3.38e-04179343f65889bf1e41396979cce44a5e63f49dea2bbd9b
ToppCellLV|World / Chamber and Cluster_Paper

IL1RAPL1 PLCXD3 PDZRN3

3.44e-041803435ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCellControl-Endothelial_cells-Capillary_endothelial_cells|Control / group, cell type (main and fine annotations)

IL1RAPL1 PLCXD3 ACE

3.44e-04180343b043f9ffb9a4cd427a15bebb86a711c7b08866e8
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 FEZF2 PDZRN4

3.44e-04180343b514c55e52b46e8a1a2f09ed2c59a7683367a505
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 FEZF2 PDZRN4

3.50e-0418134308f44323bf71b6004a921bbc969c954c75feeb66
ToppCellRV|World / Chamber and Cluster_Paper

IL1RAPL1 PLCXD3 PDZRN3

3.50e-04181343bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL6A5 ST8SIA1 PDZRN3

3.50e-041813439ede19228ba5c0668a9c06c915510b95585216ef
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

IL1RAPL1 PLCXD3 ACE

3.55e-04182343a20017b6a4f9a6a29e090e4dbd7c02ed1495bd50
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_A|E18.5-samps / Age Group, Lineage, Cell class and subclass

SEMA7A ACE POLE

3.55e-04182343ea4f6c8f600ffe9f8e0609637b3371a5ac48ca03
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 ST8SIA1 FEZF2

3.61e-041833433ebe334ad570e3525341badb558f369c61daf3d3
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 FEZF2 PDZRN4

3.61e-0418334365f2a5895d166189a095cf7ea9dda171f0419b08
ToppCell3'-Broncho-tracheal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IL1RAPL1 ST8SIA1 BMP2K

3.61e-041833438b7f9e55c21c99395c71c5ac4f5db0f6c5733ef9
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 ST8SIA1 FEZF2

3.67e-041843439cc5c588f7c6631b3fb8a522214a09ca32947e72
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS16 CLSTN2 PDZRN4

3.67e-04184343ca35a3d2b536c8b2bf5c4d635605e5a3ae94a428
ToppCellTransplant_Alveoli_and_parenchyma-Immune-Mast_cells|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

IL1RAPL1 ST8SIA1 SEMA7A

3.67e-04184343bc394eaa441fcaffcc4ace062741bca1da229324
ToppCellCOVID-19-Heart-CM_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

IL1RAPL1 PLCXD3 PDZRN3

3.67e-04184343e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D122|Adult / Lineage, Cell type, age group and donor

CLSTN2 PDZRN3 PDZRN4

3.67e-041843432b7e6f91e11c228f0521e099886867d9e998e78d
ToppCellCOVID-19-Heart-CM_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

IL1RAPL1 PLCXD3 PDZRN3

3.73e-04185343549eeb521c3985bff396ea0f202db21822efa51f
ToppCellTransplant_Alveoli_and_parenchyma-Immune-Mast_cells|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

IL1RAPL1 ST8SIA1 SEMA7A

3.73e-04185343a6e5328801c233a44153420e2cdae644b253f540
ToppCell(4)_Mast_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

IL1RAPL1 SEMA7A BMP2K

3.73e-041853433dd5d2237ab50b13a41c12f85e1b79cd72ea567b
ToppCell(4)_Mast_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

IL1RAPL1 SEMA7A BMP2K

3.73e-04185343c91e1081e630a61c18f6af6d198bfcf296746852
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IL1RAPL1 SEMA7A BMP2K

3.79e-04186343f690e26b2ed024bd8ede494b8e9a00976fdc9734
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IL1RAPL1 SEMA7A BMP2K

3.85e-04187343bdcef4f3e093c3646b639a189bbe93d6f4c40f3c
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IL1RAPL1 SEMA7A BMP2K

3.85e-0418734309348f1e8bbbca8dca885461937b9b1dd248b034
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IL1RAPL1 SEMA7A BMP2K

3.85e-041873430f7a42c55997e34a0d20e492e16b03e91e965335
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IL1RAPL1 SEMA7A BMP2K

3.85e-04187343064730fa72f8637c3db3fc34d2e363d2b9a38f1d
Diseasebehavioural inhibitory control measurement

MROH2A EFR3A

1.44e-0416332EFO_0008467
Diseaseliver cirrhosis (is_implicated_in)

SPAG9 ACE

1.06e-0343332DOID:5082 (is_implicated_in)
Diseasehepatocellular carcinoma (is_implicated_in)

SPAG9 CBX4 ACE

1.08e-03181333DOID:684 (is_implicated_in)
Diseasepancreatic ductal carcinoma (is_marker_for)

TSC2 ACE

2.13e-0361332DOID:3587 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
STVHHEMGHIQYYLQ

ACE

386

P12821
KAVQIHHDTQHTMYF

AGO4

846

Q9HCK5
KTEMNRHHYALYVHN

CLSTN2

406

Q9H4D0
HHHHLLQDAYMQQYQ

BMP2K

491

Q9NSY1
MYSIQAQYSHHVIQE

EFR3A

281

Q14156
LYTKHHHTNQYYHMV

ADAMTS16

751

Q8TE57
AHIPAHAQHYQSYMQ

PDZRN3

871

Q9UPQ7
HAQHYQSYMQLIQQK

PDZRN3

876

Q9UPQ7
HARHYQSYMQLIQQK

PDZRN4

846

Q6ZMN7
YNALHQRHTEMIHNY

SPAG9

156

O60271
FHNTYHSQMRQKHYY

IL1RAPL1

611

Q9NZN1
ITQYHNIYADNQVMH

POLE

1806

Q07864
EHHTYHIKNYIMNKD

PPP4R3B

556

Q5MIZ7
NQIKAYISMHSYSQH

CPB2

301

Q96IY4
NVYMKHHDIHPINQY

POLQ

1181

O75417
LVTYNSIHQMKHHLQ

COL6A5

2361

A8TX70
QGHQYELNSKKHHQY

CBX4

116

O00257
QTLYHMHNAEYDVLH

DENND5A

151

Q6IQ26
KAFHQVYNLTFHMHT

FEZF2

396

Q8TBJ5
DMHSNLSNYHQYIVK

PIP4K2C

161

Q8TBX8
NHFSLVMYELQHHLK

MROH2A

156

A6NES4
LYHCHFYEHLNQMVK

RTTN

1481

Q86VV8
QHYMRHQKRNVYHCN

POGZ

636

Q7Z3K3
QLYHQTQHTQKMSVH

PRSS47P

141

A8MTI9
LNHVYQFEYMAQHLV

STRIP1

591

Q5VSL9
NMHEQPISHHYYDNV

ST8SIA1

301

Q92185
LNVHDHYQNMKHVIS

SNAPC1

181

Q16533
HFYGMQKYHHEKLVQ

PLCXD3

146

Q63HM9
VHKHVSMQINHYQYL

UHRF1BP1L

811

A0JNW5
QIMHYHMQHEQYRQV

VPS11

691

Q9H270
QHNLFYMLHQFLQYH

RMC1

511

Q96DM3
YHYQKVAVHRMQASH

SEMA7A

406

O75326
SYQKQQQYKHQMLHH

YLPM1

116

P49750
QAYMQYIHHRLIHLT

ZSWIM8

1766

A7E2V4
LQQMTAHKIYIHSYN

TBK1

316

Q9UHD2
VYEMLVSHIQLHYKH

TSC2

586

P49815