Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR3	6.31e-06	4	21	2	GO:0005219
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR3	1.58e-05	6	21	2	GO:0048763
GeneOntologyMolecularFunction	retinoic acid-responsive element binding	RXRA RXRB	2.21e-05	7	21	2	GO:0044323
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR1 RYR3	1.60e-04	18	21	2	GO:0015278
GeneOntologyMolecularFunction	nuclear vitamin D receptor binding	RXRA RXRB	1.60e-04	18	21	2	GO:0042809
GeneOntologyMolecularFunction	nuclear steroid receptor activity	RXRA RXRB	3.11e-04	25	21	2	GO:0003707
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RYR1 RYR3	4.81e-04	31	21	2	GO:0099604
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR1 RYR3	5.45e-04	33	21	2	GO:0005217
GeneOntologyMolecularFunction	nuclear thyroid hormone receptor binding	RXRA RXRB	5.79e-04	34	21	2	GO:0046966
GeneOntologyMolecularFunction	nuclear receptor binding	RXRA RXRB KDM5D	9.49e-04	187	21	3	GO:0016922
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	RXRA RXRB	1.51e-03	55	21	2	GO:0042974
GeneOntologyMolecularFunction	nuclear receptor activity	RXRA RXRB	1.80e-03	60	21	2	GO:0004879
GeneOntologyMolecularFunction	ligand-activated transcription factor activity	RXRA RXRB	1.86e-03	61	21	2	GO:0098531
GeneOntologyMolecularFunction	calcium channel activity	RYR1 RYR3	8.03e-03	129	21	2	GO:0005262
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	RXRA RXRB KDM5D	9.09e-03	417	21	3	GO:0061629
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	RYR1 RYR3	9.39e-03	140	21	2	GO:0099094
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	RYR1 RYR3	1.09e-02	151	21	2	GO:0015085
GeneOntologyBiologicalProcess	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	RYR1 RYR3 DMD	7.99e-06	37	22	3	GO:0014808
GeneOntologyBiologicalProcess	release of sequestered calcium ion into cytosol by endoplasmic reticulum	RYR1 RYR3 DMD	9.39e-06	39	22	3	GO:1903514
GeneOntologyBiologicalProcess	sarcoplasmic reticulum calcium ion transport	RYR1 RYR3 DMD	1.36e-05	44	22	3	GO:0070296
GeneOntologyBiologicalProcess	positive regulation of vitamin D receptor signaling pathway	RXRA RXRB	1.62e-05	6	22	2	GO:0070564
GeneOntologyBiologicalProcess	regulation of vitamin D receptor signaling pathway	RXRA RXRB	4.86e-05	10	22	2	GO:0070562
GeneOntologyBiologicalProcess	cellular response to caffeine	RYR1 RYR3	5.94e-05	11	22	2	GO:0071313
GeneOntologyBiologicalProcess	vitamin D receptor signaling pathway	RXRA RXRB	7.12e-05	12	22	2	GO:0070561
GeneOntologyBiologicalProcess	cellular response to purine-containing compound	RYR1 RYR3	9.81e-05	14	22	2	GO:0071415
GeneOntologyBiologicalProcess	epithelial cell differentiation involved in prostate gland development	PSAPL1 RXRA	1.13e-04	15	22	2	GO:0060742
GeneOntologyBiologicalProcess	ventricular cardiac muscle cell differentiation	RXRA RXRB	1.84e-04	19	22	2	GO:0055012
GeneOntologyBiologicalProcess	response to caffeine	RYR1 RYR3	2.25e-04	21	22	2	GO:0031000
GeneOntologyBiologicalProcess	cellular response to ATP	RYR1 RYR3	2.25e-04	21	22	2	GO:0071318
GeneOntologyBiologicalProcess	cellular response to vitamin D	RXRA RXRB	2.71e-04	23	22	2	GO:0071305
GeneOntologyBiologicalProcess	cellular response to organic cyclic compound	RXRA RXRB RYR1 RYR3 KDM5D	3.72e-04	605	22	5	GO:0071407
GeneOntologyBiologicalProcess	release of sequestered calcium ion into cytosol	RYR1 RYR3 DMD	4.85e-04	146	22	3	GO:0051209
GeneOntologyBiologicalProcess	negative regulation of sequestering of calcium ion	RYR1 RYR3 DMD	4.95e-04	147	22	3	GO:0051283
GeneOntologyBiologicalProcess	cellular response to vitamin	RXRA RXRB	4.96e-04	31	22	2	GO:0071295
GeneOntologyBiologicalProcess	regulation of sequestering of calcium ion	RYR1 RYR3 DMD	5.14e-04	149	22	3	GO:0051282
GeneOntologyBiologicalProcess	sequestering of calcium ion	RYR1 RYR3 DMD	5.56e-04	153	22	3	GO:0051208
GeneOntologyBiologicalProcess	steroid hormone receptor signaling pathway	RXRA RXRB KDM5D	5.77e-04	155	22	3	GO:0043401
GeneOntologyBiologicalProcess	reproductive structure development	PSAPL1 MEA1 RXRA TEX11	6.57e-04	383	22	4	GO:0048608
GeneOntologyBiologicalProcess	reproductive system development	PSAPL1 MEA1 RXRA TEX11	6.90e-04	388	22	4	GO:0061458
GeneOntologyBiologicalProcess	striated muscle cell differentiation	RXRA RXRB RYR1 DMD	7.10e-04	391	22	4	GO:0051146
GeneOntologyBiologicalProcess	maintenance of location	OSBPL11 RYR1 RYR3 DMD	7.44e-04	396	22	4	GO:0051235
GeneOntologyBiologicalProcess	retinoic acid receptor signaling pathway	RXRA RXRB	7.46e-04	38	22	2	GO:0048384
GeneOntologyBiologicalProcess	response to vitamin D	RXRA RXRB	7.46e-04	38	22	2	GO:0033280
GeneOntologyBiologicalProcess	muscle contraction	RYR1 GRIP2 RYR3 DMD	7.73e-04	400	22	4	GO:0006936
GeneOntologyBiologicalProcess	response to ATP	RYR1 RYR3	8.27e-04	40	22	2	GO:0033198
GeneOntologyBiologicalProcess	cellular response to alkaloid	RYR1 RYR3	8.27e-04	40	22	2	GO:0071312
GeneOntologyBiologicalProcess	maternal placenta development	RXRA RXRB	1.00e-03	44	22	2	GO:0001893
GeneOntologyBiologicalProcess	regulation of response to nutrient levels	RXRA RXRB	1.09e-03	46	22	2	GO:0032107
GeneOntologyBiologicalProcess	positive regulation of bone mineralization	RXRA RXRB	1.24e-03	49	22	2	GO:0030501
GeneOntologyBiologicalProcess	nuclear receptor-mediated signaling pathway	RXRA RXRB KDM5D	1.24e-03	202	22	3	GO:0141193
GeneOntologyBiologicalProcess	multicellular organismal reproductive process	CATSPERZ MEA1 RXRA RXRB DMD TEX11	1.24e-03	1194	22	6	GO:0048609
GeneOntologyBiologicalProcess	mRNA transcription by RNA polymerase II	RXRA RXRB	1.39e-03	52	22	2	GO:0042789
GeneOntologyBiologicalProcess	developmental process involved in reproduction	CATSPERZ PSAPL1 MEA1 RXRA RXRB TEX11	1.48e-03	1235	22	6	GO:0003006
GeneOntologyBiologicalProcess	myotube cell development	RYR1 DMD	1.50e-03	54	22	2	GO:0014904
GeneOntologyBiologicalProcess	striated muscle contraction	RYR1 RYR3 DMD	1.53e-03	217	22	3	GO:0006941
GeneOntologyBiologicalProcess	calcium ion transmembrane import into cytosol	RYR1 RYR3 DMD	1.53e-03	217	22	3	GO:0097553
GeneOntologyBiologicalProcess	cellular response to nutrient	RXRA RXRB	1.56e-03	55	22	2	GO:0031670
GeneOntologyBiologicalProcess	mRNA transcription	RXRA RXRB	1.67e-03	57	22	2	GO:0009299
GeneOntologyBiologicalProcess	positive regulation of biomineral tissue development	RXRA RXRB	1.85e-03	60	22	2	GO:0070169
GeneOntologyBiologicalProcess	male meiotic nuclear division	CATSPERZ TEX11	1.85e-03	60	22	2	GO:0007140
GeneOntologyBiologicalProcess	prostate gland development	PSAPL1 RXRA	1.98e-03	62	22	2	GO:0030850
GeneOntologyBiologicalProcess	cellular response to steroid hormone stimulus	RXRA RXRB KDM5D	2.01e-03	239	22	3	GO:0071383
GeneOntologyBiologicalProcess	hormone-mediated signaling pathway	RXRA RXRB KDM5D	2.13e-03	244	22	3	GO:0009755
GeneOntologyBiologicalProcess	muscle cell differentiation	RXRA RXRB RYR1 DMD	2.20e-03	531	22	4	GO:0042692
GeneOntologyBiologicalProcess	positive regulation of ossification	RXRA RXRB	2.24e-03	66	22	2	GO:0045778
GeneOntologyBiologicalProcess	phosphatidylinositol phosphate biosynthetic process	SMG1 PIP4K2A	2.24e-03	66	22	2	GO:0046854
GeneOntologyBiologicalProcess	regulation of myelination	RXRA RXRB	2.30e-03	67	22	2	GO:0031641
GeneOntologyBiologicalProcess	developmental growth	PSAPL1 RXRA RXRB ALPI DMD	2.34e-03	911	22	5	GO:0048589
GeneOntologyBiologicalProcess	organ growth	PSAPL1 RXRA RXRB	2.44e-03	256	22	3	GO:0035265
GeneOntologyBiologicalProcess	muscle system process	RYR1 GRIP2 RYR3 DMD	2.45e-03	547	22	4	GO:0003012
GeneOntologyBiologicalProcess	maintenance of location in cell	RYR1 RYR3 DMD	2.53e-03	259	22	3	GO:0051651
GeneOntologyBiologicalProcess	cellular response to nutrient levels	GCN1 RXRA RXRB	2.61e-03	262	22	3	GO:0031669
GeneOntologyBiologicalProcess	muscle tissue development	RXRA RXRB RYR1 DMD	2.63e-03	558	22	4	GO:0060537
GeneOntologyBiologicalProcess	calcium-mediated signaling	RYR1 RYR3 DMD	2.72e-03	266	22	3	GO:0019722
GeneOntologyBiologicalProcess	maternal process involved in female pregnancy	RXRA RXRB	2.73e-03	73	22	2	GO:0060135
GeneOntologyBiologicalProcess	protein homotetramerization	RYR1 RYR3	3.03e-03	77	22	2	GO:0051289
GeneOntologyBiologicalProcess	urogenital system development	PSAPL1 RXRA	3.18e-03	79	22	2	GO:0001655
GeneOntologyBiologicalProcess	cardiac muscle cell proliferation	RXRA RXRB	3.43e-03	82	22	2	GO:0060038
GeneOntologyBiologicalProcess	intracellular monoatomic cation homeostasis	STEAP3 RYR1 RYR3 DMD	3.65e-03	611	22	4	GO:0030003
GeneOntologyBiologicalProcess	intracellular monoatomic ion homeostasis	STEAP3 RYR1 RYR3 DMD	3.89e-03	622	22	4	GO:0006873
GeneOntologyBiologicalProcess	inorganic ion homeostasis	STEAP3 RYR1 RYR3 DMD	3.89e-03	622	22	4	GO:0098771
GeneOntologyBiologicalProcess	cellular response to calcium ion	RYR1 RYR3	3.93e-03	88	22	2	GO:0071277
GeneOntologyBiologicalProcess	regulation of bone mineralization	RXRA RXRB	4.20e-03	91	22	2	GO:0030500
GeneOntologyBiologicalProcess	response to organic cyclic compound	RXRA RXRB RYR1 RYR3 KDM5D	4.28e-03	1048	22	5	GO:0014070
GeneOntologyCellularComponent	junctional membrane complex	RYR1 RYR3	3.79e-05	9	22	2	GO:0030314
GeneOntologyCellularComponent	calcium channel complex	CATSPERZ RYR1 RYR3	6.00e-05	73	22	3	GO:0034704
GeneOntologyCellularComponent	myofibril	RYR1 RYR3 ALPI DMD	1.73e-04	273	22	4	GO:0030016
GeneOntologyCellularComponent	contractile muscle fiber	RYR1 RYR3 ALPI DMD	2.18e-04	290	22	4	GO:0043292
GeneOntologyCellularComponent	Z disc	RYR1 RYR3 DMD	5.14e-04	151	22	3	GO:0030018
GeneOntologyCellularComponent	I band	RYR1 RYR3 DMD	6.78e-04	166	22	3	GO:0031674
GeneOntologyCellularComponent	sarcolemma	RYR1 RYR3 DMD	1.00e-03	190	22	3	GO:0042383
GeneOntologyCellularComponent	sarcoplasmic reticulum membrane	RYR1 RYR3	1.02e-03	45	22	2	GO:0033017
GeneOntologyCellularComponent	smooth endoplasmic reticulum	RYR1 RYR3	1.06e-03	46	22	2	GO:0005790
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CATSPERZ RYR1	1.06e-03	46	22	2	GO:0005891
GeneOntologyCellularComponent	cation channel complex	CATSPERZ RYR1 RYR3	1.84e-03	235	22	3	GO:0034703
GeneOntologyCellularComponent	sarcomere	RYR1 RYR3 DMD	2.17e-03	249	22	3	GO:0030017
GeneOntologyCellularComponent	sarcoplasmic reticulum	RYR1 RYR3	3.83e-03	88	22	2	GO:0016529
MousePheno	abnormal lens topology	HSF4 RXRA	9.12e-05	12	17	2	MP:0020486
MousePheno	translucent skin	RXRA RYR1	1.45e-04	15	17	2	MP:0001201
MousePheno	skeletal muscle fiber degeneration	RYR1 DMD	2.88e-04	21	17	2	MP:0009412
MousePheno	decreased skeletal muscle fiber number	RYR1 DMD	2.88e-04	21	17	2	MP:0009406
MousePheno	abnormal sarcoplasmic reticulum morphology	RYR1 DMD	3.47e-04	23	17	2	MP:0004088
MousePheno	decreased skeletal muscle weight	RYR1 DMD	3.78e-04	24	17	2	MP:0010239
MousePheno	impaired muscle contractility	RXRA RYR1 RYR3 DMD	3.82e-04	297	17	4	MP:0000738
MousePheno	impaired muscle relaxation	RYR1 DMD	5.16e-04	28	17	2	MP:0003157
MousePheno	abnormal skeletal muscle weight	RYR1 DMD	5.54e-04	29	17	2	MP:0010237
MousePheno	skeletal muscle degeneration	RYR1 DMD	5.94e-04	30	17	2	MP:0009415
MousePheno	abnormal muscle electrophysiology	RYR1 DMD	6.76e-04	32	17	2	MP:0004145
MousePheno	decreased muscle weight	RYR1 DMD	7.63e-04	34	17	2	MP:0004232
MousePheno	increased total tissue mass	SMG1 RYR1 ALPI DMD	8.22e-04	364	17	4	MP:0012323
MousePheno	increased body weight	SMG1 RYR1 ALPI DMD	8.22e-04	364	17	4	MP:0001260
MousePheno	decreased cardiac output	RXRA DMD	9.04e-04	37	17	2	MP:0003393
MousePheno	decreased skeletal muscle fiber diameter	RYR1 DMD	1.16e-03	42	17	2	MP:0009402
MousePheno	increased variability of skeletal muscle fiber size	RYR1 DMD	1.22e-03	43	17	2	MP:0009403
MousePheno	increased body size	SMG1 RYR1 ALPI DMD	1.27e-03	409	17	4	MP:0001264
MousePheno	abnormal muscle weight	RYR1 DMD	1.28e-03	44	17	2	MP:0004233
MousePheno	impaired skeletal muscle contractility	RYR1 DMD	1.28e-03	44	17	2	MP:0002841
MousePheno	abnormal muscle contractility	RXRA RYR1 RYR3 DMD	1.38e-03	418	17	4	MP:0005620
Domain	RyR	RYR1 RYR3	3.61e-06	3	21	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR3	3.61e-06	3	21	2	IPR003032
Domain	RR_TM4-6	RYR1 RYR3	3.61e-06	3	21	2	PF06459
Domain	Ryanrecept_TM4-6	RYR1 RYR3	3.61e-06	3	21	2	IPR009460
Domain	Ryan_recept	RYR1 RYR3	3.61e-06	3	21	2	IPR013333
Domain	RIH_assoc	RYR1 RYR3	1.80e-05	6	21	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR3	1.80e-05	6	21	2	IPR013662
Domain	RYDR_ITPR	RYR1 RYR3	1.80e-05	6	21	2	PF01365
Domain	RIH_dom	RYR1 RYR3	1.80e-05	6	21	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR3	1.80e-05	6	21	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR3	1.80e-05	6	21	2	IPR015925
Domain	Ins145_P3_rec	RYR1 RYR3	1.80e-05	6	21	2	PF08709
Domain	-	RYR1 RYR3	1.80e-05	6	21	2	1.25.10.30
Domain	Retinoid-X_rcpt/HNF4	RXRA RXRB	5.39e-05	10	21	2	IPR000003
Domain	MIR	RYR1 RYR3	5.39e-05	10	21	2	PS50919
Domain	MIR	RYR1 RYR3	5.39e-05	10	21	2	PF02815
Domain	MIR	RYR1 RYR3	5.39e-05	10	21	2	SM00472
Domain	MIR_motif	RYR1 RYR3	5.39e-05	10	21	2	IPR016093
Domain	HEAT_REPEAT	SMG1 GCN1 MROH1	6.39e-05	70	21	3	PS50077
Domain	HEAT_type_2	GCN1 MROH1	1.62e-04	17	21	2	IPR021133
Domain	ARM-type_fold	SMG1 GCN1 RYR3 MROH1	5.00e-04	339	21	4	IPR016024
Domain	zf-C4	RXRA RXRB	1.21e-03	46	21	2	PF00105
Domain	NUCLEAR_REC_DBD_1	RXRA RXRB	1.21e-03	46	21	2	PS00031
Domain	Znf_hrmn_rcpt	RXRA RXRB	1.21e-03	46	21	2	IPR001628
Domain	Nuclear_hrmn_rcpt	RXRA RXRB	1.21e-03	46	21	2	IPR001723
Domain	ZnF_C4	RXRA RXRB	1.21e-03	46	21	2	SM00399
Domain	NUCLEAR_REC_DBD_2	RXRA RXRB	1.21e-03	46	21	2	PS51030
Domain	-	RXRA RXRB	1.26e-03	47	21	2	1.10.565.10
Domain	HOLI	RXRA RXRB	1.32e-03	48	21	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	RXRA RXRB	1.32e-03	48	21	2	IPR000536
Domain	Hormone_recep	RXRA RXRB	1.32e-03	48	21	2	PF00104
Domain	HEAT	GCN1 MROH1	1.32e-03	48	21	2	PF02985
Domain	-	RXRA RXRB	1.85e-03	57	21	2	3.30.50.10
Domain	HEAT	GCN1 MROH1	1.92e-03	58	21	2	IPR000357
Domain	Znf_NHR/GATA	RXRA RXRB	1.92e-03	58	21	2	IPR013088
Domain	-	RYR1 RYR3 DMD	2.98e-03	261	21	3	1.10.238.10
Domain	ARM-like	SMG1 GCN1 MROH1	3.28e-03	270	21	3	IPR011989
Domain	EF-hand-dom_pair	RYR1 RYR3 DMD	3.89e-03	287	21	3	IPR011992
Domain	SPRY	RYR1 RYR3	4.25e-03	87	21	2	SM00449
Domain	SPRY	RYR1 RYR3	4.95e-03	94	21	2	PF00622
Domain	SPRY_dom	RYR1 RYR3	4.95e-03	94	21	2	IPR003877
Domain	B30.2/SPRY	RYR1 RYR3	5.05e-03	95	21	2	IPR001870
Domain	B302_SPRY	RYR1 RYR3	5.05e-03	95	21	2	PS50188
Domain	Ion_trans_dom	RYR1 RYR3	7.19e-03	114	21	2	IPR005821
Domain	Ion_trans	RYR1 RYR3	7.19e-03	114	21	2	PF00520
Pathway	KEGG_MEDICUS_VARIANT_PAX8_PPARG_FUSION_TO_PPARG_MEDIATED_TRANSCRIPTION	RXRA RXRB	1.54e-05	5	18	2	M49023
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_GLUCONEOGENESIS	RXRA RXRB	1.54e-05	5	18	2	M29812
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_LIMIT_CHOLESTEROL_UPTAKE	RXRA RXRB	1.54e-05	5	18	2	M29791
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_TRIGLYCERIDE_LIPOLYSIS_IN_ADIPOSE	RXRA RXRB	1.54e-05	5	18	2	M29792
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS	RXRA RXRB	2.30e-05	6	18	2	MM15663
Pathway	WP_VITAMIN_A1_AND_A5X_PATHWAYS	RXRA RXRB	2.30e-05	6	18	2	M48097
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS	RXRA RXRB	5.51e-05	9	18	2	M29809
Pathway	KEGG_MEDICUS_REFERENCE_THYROID_HORMONE_SIGNALING_PATHWAY	RXRA RXRB	5.51e-05	9	18	2	M47629
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_LIPOGENESIS	RXRA RXRB	5.51e-05	9	18	2	M29789
Pathway	WP_VITAMIN_D_METABOLISM	RXRA RXRB	6.89e-05	10	18	2	M39352
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	RYR1 RYR3	8.41e-05	11	18	2	M47958
Pathway	WP_NONGENOMIC_ACTIONS_OF_125_DIHYDROXYVITAMIN_D3	RXRA RXRB IFNAR2	1.11e-04	75	18	3	M39568
Pathway	WP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING	RYR1 RYR3	1.19e-04	13	18	2	M39589
Pathway	REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING	RXRA RXRB	1.19e-04	13	18	2	MM15622
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	RYR1 RYR3	2.60e-04	19	18	2	M47760
Pathway	PID_RXR_VDR_PATHWAY	RXRA RXRB	4.91e-04	26	18	2	M162
Pathway	KEGG_THYROID_CANCER	RXRA RXRB	6.13e-04	29	18	2	M523
Pathway	PID_RETINOIC_ACID_PATHWAY	RXRA RXRB	6.56e-04	30	18	2	M207
Pathway	REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX	RXRA RXRB	9.99e-04	37	18	2	M29790
Pathway	WP_NUCLEAR_RECEPTORS	RXRA RXRB	1.05e-03	38	18	2	MM15865
Pathway	WP_NUCLEAR_RECEPTORS	RXRA RXRB	1.05e-03	38	18	2	M39657
Pathway	REACTOME_MUSCLE_CONTRACTION	RYR1 RYR3 DMD	1.13e-03	165	18	3	MM15026
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	STEAP3 INTS9 RXRA RXRB PIP4K2A RAD17	1.24e-03	1022	18	6	MM15436
Pathway	WP_VITAMIN_A_AND_CAROTENOID_METABOLISM	RXRA RXRB	1.35e-03	43	18	2	M39554
Pathway	REACTOME_SIGNALING_BY_RETINOIC_ACID	RXRA RXRB	1.35e-03	43	18	2	M27443
Pathway	WP_RETINOL_METABOLISM	RXRA RXRB	1.41e-03	44	18	2	MM15851
Pathway	PID_A6B1_A6B4_INTEGRIN_PATHWAY	RXRA RXRB	1.54e-03	46	18	2	M239
Pathway	REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING	RXRA RXRB	1.61e-03	47	18	2	M29777
Pathway	REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	RXRA RXRB	1.68e-03	48	18	2	MM14987
Pathway	REACTOME_SIGNALING_BY_RETINOIC_ACID	RXRA RXRB	1.75e-03	49	18	2	MM15186
Pathway	REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	RXRA RXRB	2.04e-03	53	18	2	M8276
Pathway	PID_AR_TF_PATHWAY	RXRA RXRB	2.04e-03	53	18	2	M151
Pathway	REACTOME_MUSCLE_CONTRACTION	RYR1 RYR3 DMD	2.05e-03	203	18	3	M5485
Pathway	REACTOME_ION_HOMEOSTASIS	RYR1 RYR3	2.12e-03	54	18	2	MM15202
Pathway	REACTOME_ION_HOMEOSTASIS	RYR1 RYR3	2.12e-03	54	18	2	M27460
Pathway	KEGG_NON_SMALL_CELL_LUNG_CANCER	RXRA RXRB	2.12e-03	54	18	2	M19818
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	STEAP3 RXRA RXRB PIP4K2A RAD17	2.24e-03	768	18	5	MM14851
Pathway	WP_PPAR_SIGNALING	RXRA RXRB	3.24e-03	67	18	2	M39553
Pathway	KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY	RXRA RXRB	3.24e-03	67	18	2	M10462
Pathway	KEGG_PPAR_SIGNALING_PATHWAY	RXRA RXRB	3.43e-03	69	18	2	M13088
Pathway	WP_NONSMALL_CELL_LUNG_CANCER	RXRA RXRB	3.73e-03	72	18	2	M39738
Pathway	WP_PPAR_SIGNALING_PATHWAY	RXRA RXRB	3.84e-03	73	18	2	MM15995
Pathway	WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY	RYR1 DMD	3.94e-03	74	18	2	M48080
Pathway	KEGG_SMALL_CELL_LUNG_CANCER	RXRA RXRB	5.05e-03	84	18	2	M3228
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	STEAP3 INTS9 RXRA RXRB PIP4K2A RAD17	5.89e-03	1387	18	6	M734
Pubmed	Genetic variant of RXR involved in the vitamin D metabolic pathway was linked to HCV infection outcomes among a high-risk Chinese population.	RXRA RXRB	3.82e-07	2	22	2	33246082
Pubmed	RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.	RXRA RXRB	3.82e-07	2	22	2	7926783
Pubmed	Endogenous retinoid X receptor ligands in mouse hematopoietic cells.	RXRA RXRB	3.82e-07	2	22	2	29089448
Pubmed	Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.	RYR1 RYR3	3.82e-07	2	22	2	15894801
Pubmed	Three retinoid X receptor gene polymorphisms in plaque psoriasis and psoriasis guttata.	RXRA RXRB	3.82e-07	2	22	2	17341859
Pubmed	Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.	RYR1 RYR3	3.82e-07	2	22	2	9799464
Pubmed	Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.	RYR1 RYR3	3.82e-07	2	22	2	9817784
Pubmed	Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.	RYR1 RYR3	3.82e-07	2	22	2	12565913
Pubmed	Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.	RXRA RXRB	3.82e-07	2	22	2	16199515
Pubmed	Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.	RYR1 RYR3	3.82e-07	2	22	2	9489997
Pubmed	Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.	RYR1 RYR3	3.82e-07	2	22	2	9192302
Pubmed	Retinoid-X-receptors (α/β) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation.	RXRA RXRB	3.82e-07	2	22	2	24810760
Pubmed	The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.	RYR1 RYR3	3.82e-07	2	22	2	12640042
Pubmed	Limited degradation of retinoid X receptor by calpain.	RXRA RXRB	3.82e-07	2	22	2	8780715
Pubmed	Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ß-cells.	RXRA RXRB	3.82e-07	2	22	2	20798333
Pubmed	A transcriptionally silent RXRalpha supports early embryonic morphogenesis and heart development.	RXRA RXRB	3.82e-07	2	22	2	19255444
Pubmed	Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity.	RXRA RXRB	3.82e-07	2	22	2	22316320
Pubmed	Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.	RYR1 RYR3	3.82e-07	2	22	2	7556644
Pubmed	Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.	RYR1 RYR3	3.82e-07	2	22	2	14592949
Pubmed	Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.	RYR1 RYR3	3.82e-07	2	22	2	17118445
Pubmed	RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.	RYR1 RYR3	3.82e-07	2	22	2	11500519
Pubmed	Retinoid X receptors: X-ploring their (patho)physiological functions.	RXRA RXRB	1.15e-06	3	22	2	15608692
Pubmed	Chromosomal localization of the human retinoid X receptors.	RXRA RXRB	1.15e-06	3	22	2	8034312
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR3	1.15e-06	3	22	2	9242641
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR3	1.15e-06	3	22	2	18403125
Pubmed	Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.	RYR1 RYR3	1.15e-06	3	22	2	11171121
Pubmed	Unique response pathways are established by allosteric interactions among nuclear hormone receptors.	RXRA RXRB	1.15e-06	3	22	2	7758108
Pubmed	Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.	RYR1 RYR3	1.15e-06	3	22	2	18313230
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR3	1.15e-06	3	22	2	22948152
Pubmed	The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.	RXRA RXRB	1.15e-06	3	22	2	9727070
Pubmed	Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition.	RXRA RXRB	1.15e-06	3	22	2	7831303
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR3	1.15e-06	3	22	2	10788707
Pubmed	Differential 9-cis-retinoic acid-dependent transcriptional activation by murine retinoid X receptor alpha (RXR alpha) and RXR beta. Role of cell type and RXR domains.	RXRA RXRB	1.15e-06	3	22	2	8631847
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR3	1.15e-06	3	22	2	18434746
Pubmed	Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma.	RXRA RXRB	1.15e-06	3	22	2	19188585
Pubmed	Retinoid receptors trigger neuritogenesis in retinal degenerations.	RXRA RXRB	1.15e-06	3	22	2	21940995
Pubmed	An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita.	RXRA RXRB	1.15e-06	3	22	2	7990953
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR3	1.15e-06	3	22	2	25239916
Pubmed	The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer.	RXRA RXRB	1.15e-06	3	22	2	11839661
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR3	1.15e-06	3	22	2	7621815
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR3	1.15e-06	3	22	2	9204703
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR3	1.15e-06	3	22	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR3	1.15e-06	3	22	2	11159936
Pubmed	Vitamin-D receptor agonist calcitriol reduces calcification in vitro through selective upregulation of SLC20A2 but not SLC20A1 or XPR1.	RXRA RXRB	1.15e-06	3	22	2	27184385
Pubmed	The genomic and clinical landscape of fetal akinesia.	GCN1 RYR3	1.15e-06	3	22	2	31680123
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR3	1.15e-06	3	22	2	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR3	1.15e-06	3	22	2	21881589
Pubmed	Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.	RXRA RXRB	1.15e-06	3	22	2	1312497
Pubmed	Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription.	RXRA RXRB	1.15e-06	3	22	2	19897601
Pubmed	Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China.	RXRA RXRB	1.15e-06	3	22	2	18375961
Pubmed	Detection of retinoid X receptors using specific monoclonal and polyclonal antibodies.	RXRA RXRB	1.15e-06	3	22	2	7980510
Pubmed	Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles.	RXRA RXRB	1.15e-06	3	22	2	18217139
Pubmed	Differential regulation of ligand-dependent and ligand-independent functions of the mouse retinoid X receptor beta by alternative splicing.	RXRA RXRB	1.15e-06	3	22	2	10049761
Pubmed	Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate.	RXRA RXRB	1.15e-06	3	22	2	12514092
Pubmed	Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects.	RXRA RXRB	1.15e-06	3	22	2	11053444
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR3	1.15e-06	3	22	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR3	1.15e-06	3	22	2	7959768
Pubmed	RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.	RXRA RXRB	1.15e-06	3	22	2	8799145
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR3	1.15e-06	3	22	2	12213830
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR3	1.15e-06	3	22	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR3	1.15e-06	3	22	2	7635066
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 RYR3	2.29e-06	4	22	2	22100703
Pubmed	The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression.	RXRA RXRB	2.29e-06	4	22	2	10594021
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR3	2.29e-06	4	22	2	9384575
Pubmed	Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors.	RXRA RXRB	2.29e-06	4	22	2	8670810
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR3	2.29e-06	4	22	2	18206662
Pubmed	Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis.	RXRA RXRB	2.29e-06	4	22	2	9804293
Pubmed	Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.	RXRA RXRB	2.29e-06	4	22	2	1310259
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR3	2.29e-06	4	22	2	9607712
Pubmed	Sequence and characterization of a coactivator for the steroid hormone receptor superfamily.	RXRA RXRB	2.29e-06	4	22	2	7481822
Pubmed	Retinoic acid biosynthetic activity and retinoid receptors in the olfactory mucosa of adult mice.	RXRA RXRB	2.29e-06	4	22	2	10079186
Pubmed	Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand.	RXRA RXRB	2.29e-06	4	22	2	8524212
Pubmed	RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression.	RXRA RXRB	2.29e-06	4	22	2	32246014
Pubmed	The retinoid receptors.	RXRA RXRB	2.29e-06	4	22	2	7967725
Pubmed	Pregnane X Receptor Expression in Human Pancreatic Adenocarcinoma: Associations With Clinicopathologic Parameters, Tumor Proliferative Capacity, Patients' Survival, and Retinoid X Receptor Expression.	RXRA RXRB	2.29e-06	4	22	2	26355550
Pubmed	Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle.	RYR1 DMD	2.29e-06	4	22	2	19198614
Pubmed	Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells.	RXRA RXRB	2.29e-06	4	22	2	10611353
Pubmed	Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity.	RXRA RXRB	2.29e-06	4	22	2	12549917
Pubmed	Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.	RXRA RXRB	2.29e-06	4	22	2	19686701
Pubmed	Retinoid X receptors are essential for early mouse development and placentogenesis.	RXRA RXRB	2.29e-06	4	22	2	9892670
Pubmed	Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells.	RXRA RXRB	2.29e-06	4	22	2	9348290
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR3	2.29e-06	4	22	2	23482488
Pubmed	iNOS is not responsible for RyR1 S-nitrosylation in mdx mice with truncated dystrophin.	RYR1 DMD	2.29e-06	4	22	2	32693782
Pubmed	Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.	RXRA RXRB	2.29e-06	4	22	2	25574839
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR3	2.29e-06	4	22	2	23413940
Pubmed	Retinoic X receptor subtypes exert differential effects on the regulation of Trh transcription.	RXRA RXRB	2.29e-06	4	22	2	23896434
Pubmed	STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle.	RYR1 DMD	2.29e-06	4	22	2	18488020
Pubmed	Retinoic acid signaling is necessary for the development of the organ of Corti.	RXRA RXRB	3.82e-06	5	22	2	10452855
Pubmed	A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.	RXRA RXRB	3.82e-06	5	22	2	7705655
Pubmed	Developmental expression of murine retinoid X receptor (RXR) genes.	RXRA RXRB	3.82e-06	5	22	2	8199055
Pubmed	Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development.	RXRA RXRB	3.82e-06	5	22	2	9053308
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR3	3.82e-06	5	22	2	19011160
Pubmed	Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.	RXRA RXRB	3.82e-06	5	22	2	16880407
Pubmed	Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein.	RXRA RXRB	3.82e-06	5	22	2	1331778
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR3	3.82e-06	5	22	2	23918386
Pubmed	Peroxisome proliferator-activated receptors modulate proliferation and angiogenesis in human endometrial carcinoma.	RXRA RXRB	5.72e-06	6	22	2	22205725
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR3	5.72e-06	6	22	2	19549818
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR3	5.72e-06	6	22	2	19009018
Pubmed	The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development.	RXRA RXRB	5.72e-06	6	22	2	9806918
Pubmed	Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes.	RXRA RXRB	5.72e-06	6	22	2	11328745
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR3	1.43e-06	3	13	2	287
GeneFamily	Nuclear hormone receptors	RXRA RXRB	5.51e-04	49	13	2	71
Drug	5'-adenylyl (beta,gamma-methylene)diphosphonate	RYR1 RYR3	8.91e-07	2	22	2	ctd:C005147
Drug	isotetrandrine	RYR1 RYR3 ALPI KDM5D	2.13e-06	97	22	4	CID000005422
Drug	2-hydroxyheptanoic acid	RYR1 RYR3	2.67e-06	3	22	2	CID002750949
Drug	flubendiamide	RYR1 RYR3	2.67e-06	3	22	2	CID011193251
Drug	Bexarotene	RXRA RXRB	2.67e-06	3	22	2	DB00307
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR3	2.67e-06	3	22	2	CID005748312
Drug	8N3-cADPR	RYR1 RYR3	2.67e-06	3	22	2	CID000127713
Drug	2-hydroxycarbazole	RYR1 RYR3	2.67e-06	3	22	2	CID000093551
Drug	aminodantrolene	RYR1 RYR3	2.67e-06	3	22	2	CID009570289
Drug	1,1'-diheptyl-4,4'-bipyridinium	RYR1 RYR3	2.67e-06	3	22	2	CID000080262
Drug	2-hydroxyphytanic acid	RXRA RXRB	2.67e-06	3	22	2	ctd:C002585
Drug	cis-diammineplatinum(II	RYR1 RYR3	2.67e-06	3	22	2	CID000159790
Drug	AC1O5SBP	RXRA RXRB	2.67e-06	3	22	2	CID006439746
Drug	AC1L3LFV	RXRA RXRB ALPI	4.19e-06	33	22	3	CID000091134
Drug	A-30	RYR1 RYR3	5.34e-06	4	22	2	CID003028528
Drug	Bastadin 10	RYR1 RYR3	5.34e-06	4	22	2	CID009589366
Drug	SC 38249	RYR1 RYR3	5.34e-06	4	22	2	CID000134834
Drug	AC1L1U7A	RYR1 RYR3	5.34e-06	4	22	2	CID000035682
Drug	PCB74	RYR1 RYR3	5.34e-06	4	22	2	CID000036218
Drug	AGN 190727	RXRA RXRB	5.34e-06	4	22	2	CID006439768
Drug	148504-47-6	RYR1 RYR3	5.34e-06	4	22	2	CID006444275
Drug	vitamin D3 analog	RXRA RXRB KDM5D	8.15e-06	41	22	3	CID006438384
Drug	7-methoxycitronellal	RXRA RXRB	8.90e-06	5	22	2	CID000019223
Drug	13,14-dihydroretinol	RXRA RXRB	8.90e-06	5	22	2	CID000446798
Drug	7-methoxycitronellic acid	RXRA RXRB	8.90e-06	5	22	2	CID000171516
Drug	Alitretinoin	RXRA RXRB	1.33e-05	6	22	2	DB00523
Drug	NSC-635471	MEA1 KDM5D	1.33e-05	6	22	2	CID000366744
Drug	Methoprene	RXRA RXRB	1.33e-05	6	22	2	ctd:D008726
Drug	AC1O528X	RYR1 RYR3	1.33e-05	6	22	2	CID006475857
Drug	Adapalene	RXRA RXRB	1.33e-05	6	22	2	DB00210
Drug	CTMs	HSF4 MEA1	1.33e-05	6	22	2	CID000192530
Drug	Etretinate	RXRA RXRB	1.33e-05	6	22	2	DB00926
Drug	NSC114784	RYR1 RYR3	1.33e-05	6	22	2	CID000419425
Drug	NSC692750	RYR1 RYR3	1.33e-05	6	22	2	CID000078910
Drug	MBED	RYR1 RYR3	1.33e-05	6	22	2	CID000129958
Drug	triphenyltin hydroxide	RXRA RXRB	1.33e-05	6	22	2	ctd:C007567
Drug	chloro-m-cresol	RYR1 RYR3	1.33e-05	6	22	2	CID000012008
Drug	Azumoleno	RYR1 RYR3	1.87e-05	7	22	2	CID000056259
Drug	Acitretin	RXRA RXRB	1.87e-05	7	22	2	DB00459
Drug	AGN 191659	RXRA RXRB	1.87e-05	7	22	2	CID006366726
Drug	mag-indo-1	RYR1 RYR3	1.87e-05	7	22	2	CID000131881
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR1 RYR3	1.87e-05	7	22	2	CID009547999
Drug	AGN 190121	RXRA RXRB	1.87e-05	7	22	2	CID006441236
Drug	CHEBI:564108	RYR1 RYR3	1.87e-05	7	22	2	CID006400637
Drug	Br2BAPTA	RYR1 RYR3	1.87e-05	7	22	2	CID003081001
Drug	BAPNA	RYR1 RYR3 DMD	2.21e-05	57	22	3	CID000013494
Drug	HX 600	RXRA RXRB	2.49e-05	8	22	2	ctd:C104181
Drug	TTNN	RXRA RXRB	2.49e-05	8	22	2	CID000135754
Drug	AC1O5JP6	RXRA RXRB	2.49e-05	8	22	2	CID006435379
Drug	succinylcholine	RYR1 RYR3 DMD	3.14e-05	64	22	3	CID000005314
Drug	lactosyl lysosphingolipid	RYR1 RYR3	3.20e-05	9	22	2	CID006439268
Drug	FLA 365	RYR1 RYR3	3.20e-05	9	22	2	CID000072776
Drug	creatine	MEA1 RYR1 RYR3 DMD	3.25e-05	193	22	4	CID000000586
Drug	AC1N38XE	RYR1 RYR3	3.99e-05	10	22	2	CID004060965
Drug	HX 630	RXRA RXRB	3.99e-05	10	22	2	ctd:C422175
Drug	PCB 95	RYR1 RYR3	3.99e-05	10	22	2	CID000038012
Drug	diazepinylbenzoic acid	RXRA RXRB	3.99e-05	10	22	2	ctd:C438269
Drug	R 478	RYR1 RYR3	4.88e-05	11	22	2	CID000084223
Drug	AGN 191701	RXRA RXRB	4.88e-05	11	22	2	CID006438168
Drug	8-amino-cADPR	RYR1 RYR3	4.88e-05	11	22	2	CID003081323
Drug	PCB 66	RYR1 RYR3	4.88e-05	11	22	2	CID000036185
Drug	UVI 3003	RXRA RXRB	4.88e-05	11	22	2	ctd:C525131
Drug	Musk T	RXRA RXRB	4.88e-05	11	22	2	CID000061014
Drug	di-n-propylphthalate	RXRA RXRB	5.85e-05	12	22	2	ctd:C106479
Drug	2-amino-2-methyl-1-propanol	MEA1 ALPI	5.85e-05	12	22	2	CID000011807
Drug	Ryanodine	RYR1 RYR3	5.85e-05	12	22	2	ctd:D012433
Drug	NSC46155	RXRA RXRB	5.85e-05	12	22	2	CID000457869
Drug	tazarotenic acid	RXRA RXRB	6.91e-05	13	22	2	CID000147525
Drug	GW2331	RXRA RXRB	6.91e-05	13	22	2	CID000657048
Drug	Cd2665	RXRA RXRB	6.91e-05	13	22	2	CID000216241
Drug	NSC299933	RYR1 RYR3	6.91e-05	13	22	2	CID000431902
Drug	europium	RYR1 RYR3 KDM5D	7.87e-05	87	22	3	CID000023981
Drug	bimoclomol	RYR1 RYR3	8.05e-05	14	22	2	CID009576891
Drug	Sulfonamides	RXRA RXRB	8.05e-05	14	22	2	ctd:D013449
Drug	cysteamine hydrochloride	MEA1 ALPI	8.05e-05	14	22	2	CID000009082
Drug	AC1L1DMQ	RXRA RXRB	8.05e-05	14	22	2	CID000002418
Drug	NP-EGTA	RYR1 RYR3	8.05e-05	14	22	2	CID000183793
Drug	FPL 64176	RYR1 RYR3	9.29e-05	15	22	2	CID000003423
Drug	Gvapspat amide	RYR1 RYR3	9.29e-05	15	22	2	CID000125015
Drug	TAT-59	ALPI DMD	1.06e-04	16	22	2	CID003034829
Drug	DM-nitrophen	RYR1 RYR3	1.06e-04	16	22	2	CID000003083
Drug	TMPone	MEA1 KDM5D	1.06e-04	16	22	2	CID000013220
Drug	strontium chromate	RYR1 RYR3 ALPI	1.16e-04	99	22	3	CID000024599
Drug	kazinol B	RYR1 RYR3	1.20e-04	17	22	2	CID000480869
Drug	phthalic acid	RXRA RXRB	1.20e-04	17	22	2	ctd:C032279
Drug	vitamin D3	RXRA RXRB ALPI KDM5D	1.32e-04	277	22	4	CID000002735
Drug	NSC635470	MEA1 KDM5D	1.35e-04	18	22	2	CID000003664
Drug	HX600	RXRA RXRB	1.35e-04	18	22	2	CID000128016
Drug	methylcoumarin	RYR1 RYR3	1.35e-04	18	22	2	CID000007092
Drug	androst-2-en-3-ol	RXRA RXRB	1.35e-04	18	22	2	CID000166036
Drug	E-guggulsterone	OSBPL11 RXRA RXRB	1.50e-04	108	22	3	CID006439929
Drug	AC1L380G	RYR1 RYR3	1.51e-04	19	22	2	CID000084698
Drug	AC1MW7VF	RYR1 RYR3	1.51e-04	19	22	2	CID000414699
Drug	thiopental	RYR1 RYR3 DMD	1.67e-04	112	22	3	CID003000715
Drug	cyanyl	RYR1 ALPI	1.68e-04	20	22	2	CID005359238
Drug	diheptyl phthalate	RXRA RXRB	1.85e-04	21	22	2	ctd:C089799
Drug	indo-1/AM	RYR1 RYR3	1.85e-04	21	22	2	CID000123918
Drug	AC1NBUB1	HSF4 KDM5D	1.85e-04	21	22	2	CID004473866
Drug	AC1L1CR9	RYR1 RYR3	1.85e-04	21	22	2	CID000002023
Drug	TCNB	RYR1 RYR3 DMD	1.99e-04	119	22	3	CID000008330
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR3	1.31e-06	3	20	2	DOID:8545 (implicated_via_orthology)
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR3	1.31e-06	3	20	2	DOID:3529 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	RYR1 RYR3 KDM5D	2.98e-04	195	20	3	DOID:1574 (implicated_via_orthology)
Disease	pulmonary hypertension (biomarker_via_orthology)	RYR1 RYR3	1.34e-03	80	20	2	DOID:6432 (biomarker_via_orthology)
Disease	influenza A (H1N1)	PIP4K2A DMD	1.58e-03	87	20	2	EFO_1001488

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLPLMELMENEALEI	CATSPERZ	146	Q9NTU4
MILDEVKMHLPALET	DMD	1476	P11532
LLVEPEEVVEMSHMP	RAD17	431	O75943
IEIMPELADSLVPME	INTS9	516	Q9NV88
APLEELMMEGDLLEV	KDM5D	1381	Q9BY66
LMELHMVLPAPDTDE	GCN1	1106	Q92616
LHSIMALLPEPKEED	MROH1	871	Q8NDA8
PLMLSSHLEEMVDPE	IFNAR2	446	P48551
EIHRDPTLDPSLMEM	ALPI	296	P09923
DLDMELSLMQPLVPE	HSF4	411	Q9ULV5
AEMEELLLPTPLEMH	GRIP2	926	Q9C0E4
PIDTFLMEMLEAPHQ	RXRA	446	P19793
EPLTMMALHIPEENR	RYR1	1631	P21817
ELSHVQIPVMLMPDD	PIP4K2A	51	P48426
NLPPDHLVEVREMMS	OSBPL11	211	Q9BXB4
IPMDPEHVELVKRTM	MEA1	131	Q16626
EPVLIESLKDMMDPV	PSAPL1	446	Q6NUJ1
PLHVMKAVLEELMEA	SMG1	2276	Q96Q15
TPIDTFLMEMLEAPH	RXRB	516	P28702
PLLLVHDMSEEMTIP	C12orf4	471	Q9NQ89
MPEEMDKPLISLHLV	STEAP3	1	Q658P3
LEPLQMMALHIPEEN	RYR3	1526	Q15413
LLEAVMEILHLDMPL	TEX11	321	Q8IYF3