Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low voltage-gated calcium channel activity	CACNA1I CACNA1H	2.31e-05	3	56	2	GO:0008332
Domain	VDCC_T_a1	CACNA1I CACNA1H	2.55e-05	3	55	2	IPR005445
Domain	VDCCAlpha1	CACNA1I CACNA1H	3.77e-04	10	55	2	IPR002077
Domain	VWFC_1	COL2A1 JAG2	5.03e-03	36	55	2	PS01208
Domain	VWC	COL2A1 JAG2	5.59e-03	38	55	2	SM00214
Domain	VWFC_2	COL2A1 JAG2	5.59e-03	38	55	2	PS50184
Domain	CYCLIN	RBL1 CCNJ	5.59e-03	38	55	2	SM00385
Domain	-	RBL1 CCNJ	6.18e-03	40	55	2	1.10.472.10
Domain	VWF_dom	COL2A1 JAG2	6.80e-03	42	55	2	IPR001007
Domain	Cyclin-like	RBL1 CCNJ	7.12e-03	43	55	2	IPR013763
Pathway	WP_4HYDROXYTAMOXIFEN_DEXAMETHASONE_AND_RETINOIC_ACIDS_REGULATION_OF_P27_EXPRESSION	PIK3R1 PRKAA1 PBK	3.38e-05	25	36	3	M39574
Pubmed	Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.	COL2A1 CACNA1I CACNA1H	4.71e-07	10	56	3	24778262
Pubmed	A T-type calcium channel required for normal function of a mammalian mechanoreceptor.	CACNA1I CACNA1H	2.55e-06	2	56	2	12808460
Pubmed	Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice.	CACNA1I CACNA1H	2.55e-06	2	56	2	25071191
Pubmed	Identification of polymorphisms in ultraconserved elements associated with clinical outcomes in locally advanced colorectal adenocarcinoma.	RBL1 TECTB	2.55e-06	2	56	2	22673945
Pubmed	Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes.	CACNA1I CACNA1H	2.55e-06	2	56	2	36786913
Pubmed	Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.	CACNA1I CACNA1H	7.63e-06	3	56	2	23488970
Pubmed	T-type channels: release a brake, engage a gear.	CACNA1I CACNA1H	7.63e-06	3	56	2	26488564
Pubmed	Differential interactions of Na+ channel toxins with T-type Ca2+ channels.	CACNA1I CACNA1H	7.63e-06	3	56	2	18591418
Pubmed	Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.	CACNA1I CACNA1H	7.63e-06	3	56	2	11230107
Pubmed	Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.	CACNA1I CACNA1H	7.63e-06	3	56	2	28846697
Pubmed	Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.	CACNA1I CACNA1H	7.63e-06	3	56	2	33547341
Pubmed	Calmodulin regulates Cav3 T-type channels at their gating brake.	CACNA1I CACNA1H	7.63e-06	3	56	2	28972185
Pubmed	Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.	CACNA1I CACNA1H	7.63e-06	3	56	2	11927664
Pubmed	Tectorins crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus.	COL2A1 TECTB	7.63e-06	3	56	2	26806019
Pubmed	Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.	CACNA1I CACNA1H	7.63e-06	3	56	2	11897840
Pubmed	Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.	CACNA1I CACNA1H	1.52e-05	4	56	2	28165634
Pubmed	TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance.	PIK3R1 PRKAA1	3.80e-05	6	56	2	24315994
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	CAND2 RASA2 PIK3R1 PRKAA1 EIF4G2 AKNAD1 LRP2 HMGXB3 TIAM2	5.45e-05	1084	56	9	11544199
Pubmed	The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.	JAG2 TECTB	7.09e-05	8	56	2	16141228
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1I CACNA1H	7.09e-05	8	56	2	28330839
Pubmed	p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development.	COL2A1 RBL1	7.09e-05	8	56	2	12086466
Pubmed	Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.	CACNA1I CACNA1H	7.09e-05	8	56	2	34478646
Pubmed	Intracellular calcium plays an essential role in cardiac development.	CACNA1I CACNA1H	7.09e-05	8	56	2	12761855
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1I CACNA1H	9.10e-05	9	56	2	16382099
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	JAG2 RASA2 ZNF827 ZFP64 ZFHX3 CACNA1H DHRSX USP15 RECK TMEM63A	1.18e-04	1489	56	10	28611215
Pubmed	RECK in Neural Precursor Cells Plays a Critical Role in Mouse Forebrain Angiogenesis.	COL2A1 RECK	1.39e-04	11	56	2	31445376
Pubmed	Altered expression of metallothionein-I and -II and their receptor megalin in inherited photoreceptor degeneration.	LRP2 PRPH2	1.66e-04	12	56	2	20357188
Pubmed	Genome-wide association study of age at menarche in African-American women.	PIK3R1 DSCAML1	1.66e-04	12	56	2	23599027
Pubmed	FGF8 Signaling Alters the Osteogenic Cell Fate in the Hard Palate.	COL2A1 PIK3R1	3.41e-04	17	56	2	29342370
Pubmed	Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation.	COL2A1 PRKAA1	3.83e-04	18	56	2	26091038
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	NAA35 ZNF827 RBL1 PIK3R1 EPC1 LRP2 ZFHX3 SENP7	3.97e-04	1116	56	8	31753913
Pubmed	In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics.	RPL27A EIF4G2 TDRD6	4.63e-04	93	56	3	25211037
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	JAG2 NAA35 TMEM201 CAND2 GLA EXD2 EIF4G2	7.64e-04	942	56	7	31073040
Pubmed	Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity.	GLA PBK	8.07e-04	26	56	2	23741361
Pubmed	Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.	COL2A1 PIK3R1	8.07e-04	26	56	2	21367821
Pubmed	Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.	COL2A1 JAG2	1.01e-03	29	56	2	25535917
Pubmed	pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development.	JAG2 RBL1	1.08e-03	30	56	2	17257418
Pubmed	Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies.	COL2A1 LRP2	1.46e-03	35	56	2	32179912
Pubmed	Development and application of a DNA microarray-based yeast two-hybrid system.	PIK3R1 LOXL1 DHRSX	1.55e-03	141	56	3	23275563
Pubmed	Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.	COL2A1 JAG2	1.55e-03	36	56	2	20672350
Cytoband	15q22	LOXL1 DPP8	5.81e-04	29	56	2	15q22
Cytoband	11p15	RPL27A EIF4G2	1.28e-03	43	56	2	11p15
GeneFamily	Calcium voltage-gated channel subunits	CACNA1I CACNA1H	1.22e-03	26	36	2	253
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF134 ZNF827 ZNF781 ZFP64 ZNF888 ZFHX3	2.70e-03	718	36	6	28
Drug	arachidonoylglycine	SLC6A5 CACNA1I CACNA1H	2.17e-06	11	55	3	CID000004345
Drug	SureCN2398996	CACNA1I CACNA1H	1.72e-05	3	55	2	CID010220069
Drug	N-desmethylmethsuximide	CACNA1I CACNA1H	1.72e-05	3	55	2	CID000092154
Drug	1,3-dioxoisoindoline-5-carboxamide	CACNA1I CACNA1H	1.72e-05	3	55	2	CID010679219
Disease	Glioblastoma Multiforme	JAG2 PIK3R1 TAF1L RECK	4.47e-05	111	52	4	C1621958
Disease	Sensory hearing loss	COL2A1 LRP2	1.66e-04	11	52	2	C1691779
Disease	membranous glomerulonephritis (biomarker_via_orthology)	LRP2 PTGER3	2.73e-04	14	52	2	DOID:10976 (biomarker_via_orthology)
Disease	renovascular hypertension (biomarker_via_orthology)	EIF4G2 PTGER3	5.11e-04	19	52	2	DOID:1591 (biomarker_via_orthology)
Disease	heart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer	GRHL1 ZFHX3	5.67e-04	20	52	2	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Disease	pantothenic acid mesurement	PIK3R1 RECK	5.67e-04	20	52	2	EFO_0010519
Disease	Sensorineural Hearing Loss (disorder)	COL2A1 LRP2	7.53e-04	23	52	2	C0018784
Disease	Pancytopenia	RPL27A FANCM	9.64e-04	26	52	2	C0030312
Disease	verbal-numerical reasoning measurement	PIK3R1 EXD2 CACNA1I	1.61e-03	131	52	3	EFO_0008394

Protein segments in the cluster

Peptide	Gene	Start	Entry
RKAGCQYYAPHLDQT	EPC1	406	Q9H2F5
KNVSSNYCLGRHLPY	nan	221	Q9N2J8
YASITRNQHIPQYCG	CTSZ	76	Q9UBR2
KPCLSVSYNRSYQIN	CCNJ	346	Q5T5M9
FQKPNYTEIRQYCNH	GLA	211	P06280
SQNITYHCKNSIAYL	COL2A1	1386	P02458
TKNHLTNPCYPRDYS	ENTPD3	281	O75355
RCNQNRLSFYHPSVY	RASA2	706	Q15283
SPQLIHCVNNYTQSY	RECK	191	O95980
AKQHISYQCPYCNRK	C8orf48	191	Q96LL4
NYYSATCNKFCRPRN	JAG2	201	Q9Y219
HTFYLQCNASPQYLK	CFAP65	851	Q6ZU64
AHKALGNYAYCQVVR	FANCM	216	Q8IYD8
NIHYTGRYVSATNCK	LOXL1	556	Q08397
SCHAISNYYDNHLKQ	EXD2	461	Q9NVH0
NPSCSYVYTNRHKPR	HMGXB3	626	Q12766
KFCQIRYHTNNYASS	PTGER3	356	P43115
YHSLRQPYATNPCKD	LRP2	651	P98164
NHYRNESLAQYNPKL	PIK3R1	406	P27986
TKYSQYNALNVPLHN	PPP1R21	231	Q6ZMI0
RPNDSYCYNSAKNST	TMEM63A	26	O94886
LYALQVHCYNSNFPK	EIF4G2	831	P78344
CEAKNRLPNYATYSH	MILR1	196	Q7Z6M3
YQSLKAQNAYSRHCP	GPR160	161	Q9UJ42
SYNNRSNKPVHRAYC	GRHL1	401	Q9NZI5
HRANKSDYCNLPLYA	DSCAML1	1891	Q8TD84
RYYNVCRTGSANPHK	CACNA1I	321	Q9P0X4
SKYSNQKNPHCVSLY	DPP8	586	Q6V1X1
CYSPHAAYAQSKLAL	DHRSX	201	Q8N5I4
RYNTPGQNYSNHSKR	AKNAD1	691	Q5T1N1
YRNCHTSNLNGQYLR	FIBCD1	411	Q8N539
NHCRLSTLGYKSYQN	KRTAP24-1	166	Q3LI83
NQYYNVCRSGDSNPH	CACNA1H	341	O95180
TSLCLQYIKHDPNYN	CAND2	301	O75155
YHLKRNQSFCPTVNL	RPL27A	61	P46776
SYQNLNPHKSCYLSE	SENP7	211	Q9BQF6
QYYCKNTAAPHQRNT	TDRD6	806	O60522
ITLSSYNKFHNNCYR	SLC6A5	486	Q9Y345
KSYRNQPQANSHVYR	RBL1	866	P28749
HMRTNKFCPLYYQTN	TAF1L	1291	Q8IZX4
KNQPVNYSFSCTYHS	TECTB	111	Q96PL2
CLYNRNHQDPLAVAY	PRKAA1	321	Q13131
ARSCLSHFKSNQPYA	TIAM2	61	Q8IVF5
SPKCYLYNNHQAKDC	NAA35	406	Q5VZE5
HPNNVVSVKYCNYTS	KIF21A	1386	Q7Z4S6
PCIQYQITNNSAHYS	PRPH2	221	P23942
RNVKNSNYCLPSYTA	USP15	256	Q9Y4E8
INPICNDHYRSVYQK	PBK	66	Q96KB5
PCQAAVEYYIKHQNR	TMEM201	166	Q5SNT2
HQYQTYKNLCNIFPS	ZC3H12B	791	Q5HYM0
PYAAKCRANLNQHLT	ZNF827	851	Q17R98
CRPKTHISNNYGNNF	ZNF888	181	P0CJ79
HPTQYCLNSYSDNSR	TRAPPC8	731	Q9Y2L5
YKCQLCPYASRNSSQ	ZFP64	386	Q9NTW7
TQYQISHANQKPYEC	ZNF781	21	Q8N8C0
ANLHQYQKCYSIEQP	ZNF134	91	P52741
NPVHLKCNACDYYTN	ZFHX3	1036	Q15911