Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	small GTPase binding	IPO8 FGD2 SYTL2 XPO4 SH3BP4 EHD1 GCC1 FGD6 IQGAP3 SORL1	4.83e-06	321	100	10	GO:0031267
GeneOntologyMolecularFunction	GTPase binding	IPO8 FGD2 SYTL2 XPO4 SH3BP4 EHD1 GCC1 FGD6 IQGAP3 SORL1	1.31e-05	360	100	10	GO:0051020
GeneOntologyBiologicalProcess	protein retention in Golgi apparatus	VPS13D VPS13A SORL1	1.10e-06	5	100	3	GO:0045053
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection assembly	ABCC4 ARHGAP24 FGD2 MKS1 EHD4 FSIP2 CELSR2 DNAH17 SYNE2 EHD1 ULK4 IFT122 FGD6 HYDIN	4.27e-06	670	100	14	GO:0120031
GeneOntologyBiologicalProcess	cell projection assembly	ABCC4 ARHGAP24 FGD2 MKS1 EHD4 FSIP2 CELSR2 DNAH17 SYNE2 EHD1 ULK4 IFT122 FGD6 HYDIN	5.50e-06	685	100	14	GO:0030031
GeneOntologyBiologicalProcess	cilium assembly	ABCC4 MKS1 EHD4 FSIP2 CELSR2 DNAH17 SYNE2 EHD1 ULK4 IFT122 HYDIN	1.03e-05	444	100	11	GO:0060271
GeneOntologyBiologicalProcess	cilium organization	ABCC4 MKS1 EHD4 FSIP2 CELSR2 DNAH17 SYNE2 EHD1 ULK4 IFT122 HYDIN	1.97e-05	476	100	11	GO:0044782
GeneOntologyBiologicalProcess	regulation of angiotensin metabolic process	SUCNR1 ACE	6.96e-05	3	100	2	GO:0060177
GeneOntologyBiologicalProcess	microtubule-based movement	FSIP2 CELSR2 DNAH17 SYNE2 VPS13A ULK4 IFT122 TRAK2 HYDIN KIF22	1.41e-04	493	100	10	GO:0007018
GeneOntologyBiologicalProcess	peptide catabolic process	ACE ERAP2 LNPEP	1.82e-04	23	100	3	GO:0043171
GeneOntologyCellularComponent	early endosome	CLTCL1 FGD2 RAPGEF1 EHD4 MTMR4 LNPEP VPS35 EHD1 TRAK2 SORL1	1.03e-04	481	100	10	GO:0005769
Domain	ARM-type_fold	CLTCL1 IPO8 XPO4 USP9Y NCDN PSME4 PI4KA VPS35 ULK4 STAG2	1.39e-05	339	100	10	IPR016024
Domain	VPS13	VPS13D VPS13A	8.48e-05	3	100	2	IPR026847
Domain	VPS13_mid_rpt	VPS13D VPS13A	8.48e-05	3	100	2	PF16910
Domain	VPS13	VPS13D VPS13A	8.48e-05	3	100	2	PF16908
Domain	VPS13_N2	VPS13D VPS13A	8.48e-05	3	100	2	IPR031646
Domain	VPS13_mid_rpt	VPS13D VPS13A	8.48e-05	3	100	2	IPR031642
Domain	DUF21	CNNM2 CNNM1	1.69e-04	4	100	2	IPR002550
Domain	SHR-BD	VPS13D VPS13A	1.69e-04	4	100	2	IPR009543
Domain	VPS13_C	VPS13D VPS13A	1.69e-04	4	100	2	PF16909
Domain	VPS13_C	VPS13D VPS13A	1.69e-04	4	100	2	IPR031645
Domain	DUF21	CNNM2 CNNM1	1.69e-04	4	100	2	PF01595
Domain	SHR-BD	VPS13D VPS13A	1.69e-04	4	100	2	PF06650
Domain	Anaphylatoxin_comp_syst	C4A C4B	2.81e-04	5	100	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	2.81e-04	5	100	2	IPR001840
Domain	EHD_N	EHD4 EHD1	2.81e-04	5	100	2	IPR031692
Domain	EHD_N	EHD4 EHD1	2.81e-04	5	100	2	PF16880
Domain	FYVE	FGD2 MTMR4 FGD6	4.92e-04	29	100	3	PF01363
Domain	FYVE	FGD2 MTMR4 FGD6	4.92e-04	29	100	3	SM00064
Domain	ANATO	C4A C4B	5.86e-04	7	100	2	SM00104
Domain	ANAPHYLATOXIN_2	C4A C4B	5.86e-04	7	100	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	5.86e-04	7	100	2	PS01177
Domain	ANATO	C4A C4B	5.86e-04	7	100	2	PF01821
Domain	Anaphylatoxin/fibulin	C4A C4B	5.86e-04	7	100	2	IPR000020
Domain	ARM-like	SETX IPO8 XPO4 USP9Y PSME4 ULK4 STAG2	6.22e-04	270	100	7	IPR011989
Domain	ERAP1-like_C_dom	ERAP2 LNPEP	7.78e-04	8	100	2	IPR024571
Domain	Chorein_N	VPS13D VPS13A	7.78e-04	8	100	2	PF12624
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	7.78e-04	8	100	2	IPR019565
Domain	VPS13_N	VPS13D VPS13A	7.78e-04	8	100	2	IPR026854
Domain	ERAP1_C	ERAP2 LNPEP	7.78e-04	8	100	2	PF11838
Domain	Thiol-ester_cl	C4A C4B	7.78e-04	8	100	2	PF10569
Domain	MacrogloblnA2_CS	C4A C4B	7.78e-04	8	100	2	IPR019742
Domain	Znf_FYVE-rel	FGD2 MTMR4 FGD6	7.90e-04	34	100	3	IPR017455
Domain	Znf_FYVE	FGD2 MTMR4 FGD6	1.10e-03	38	100	3	IPR000306
Domain	A2M	C4A C4B	1.24e-03	10	100	2	PF00207
Domain	A2M_N_2	C4A C4B	1.24e-03	10	100	2	IPR011625
Domain	A2M_comp	C4A C4B	1.24e-03	10	100	2	IPR011626
Domain	A2M_recep	C4A C4B	1.24e-03	10	100	2	PF07677
Domain	A2M_comp	C4A C4B	1.24e-03	10	100	2	PF07678
Domain	A2M_N	C4A C4B	1.24e-03	10	100	2	PF01835
Domain	A2M_N	C4A C4B	1.24e-03	10	100	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	1.24e-03	10	100	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	1.24e-03	10	100	2	PS00477
Domain	EF-hand_4	EHD4 EHD1	1.24e-03	10	100	2	PF12763
Domain	A2M_N_2	C4A C4B	1.24e-03	10	100	2	PF07703
Domain	Macroglobln_a2	C4A C4B	1.24e-03	10	100	2	IPR001599
Domain	ZF_FYVE	FGD2 MTMR4 FGD6	1.27e-03	40	100	3	PS50178
Domain	GAIN_dom_N	ADGRB3 CELSR2	1.51e-03	11	100	2	IPR032471
Domain	EH	EHD4 EHD1	1.51e-03	11	100	2	PS50031
Domain	GAIN	ADGRB3 CELSR2	1.51e-03	11	100	2	PF16489
Domain	EH	EHD4 EHD1	1.51e-03	11	100	2	SM00027
Domain	EH_dom	EHD4 EHD1	1.51e-03	11	100	2	IPR000261
Domain	Peptidase_M1	ERAP2 LNPEP	1.81e-03	12	100	2	IPR001930
Domain	ZINC_PROTEASE	ADAMTS3 ACE ERAP2 LNPEP	1.90e-03	98	100	4	PS00142
Domain	Peptidase_M1_N	ERAP2 LNPEP	2.13e-03	13	100	2	IPR014782
Domain	Peptidase_M1	ERAP2 LNPEP	2.13e-03	13	100	2	PF01433
Domain	G_DYNAMIN_dom	EHD4 EHD1	2.48e-03	14	100	2	IPR030381
Domain	G_DYNAMIN_2	EHD4 EHD1	2.48e-03	14	100	2	PS51718
Domain	Dynamin_GTPase	EHD4 EHD1	2.85e-03	15	100	2	IPR001401
Domain	Dynamin_SF	EHD4 EHD1	2.85e-03	15	100	2	IPR022812
Domain	Dynamin_N	EHD4 EHD1	2.85e-03	15	100	2	PF00350
Domain	C345C	C4A C4B	3.66e-03	17	100	2	SM00643
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	4.11e-03	18	100	2	IPR008930
Domain	NTR	C4A C4B	4.57e-03	19	100	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	4.57e-03	19	100	2	IPR018933
Domain	TSP_1	ADAMTS3 ADGRB3 C8B	4.69e-03	63	100	3	PF00090
Domain	CBS_dom	CNNM2 CNNM1	5.06e-03	20	100	2	IPR000644
Domain	CBS	CNNM2 CNNM1	5.06e-03	20	100	2	PF00571
Domain	CBS	CNNM2 CNNM1	5.06e-03	20	100	2	PS51371
Domain	TSP1	ADAMTS3 ADGRB3 C8B	5.12e-03	65	100	3	SM00209
Domain	TSP1_rpt	ADAMTS3 ADGRB3 C8B	5.12e-03	65	100	3	IPR000884
Domain	TSP1	ADAMTS3 ADGRB3 C8B	5.12e-03	65	100	3	PS50092
Pathway	REACTOME_GLYCOSAMINOGLYCAN_METABOLISM	CHST5 HMMR B4GALT6 ST3GAL6 HS3ST2 HYAL2	7.96e-05	123	82	6	MM14623
Pathway	REACTOME_GLYCOSAMINOGLYCAN_METABOLISM	CHST5 HMMR B4GALT6 ST3GAL6 HS3ST2 HYAL2	9.09e-05	126	82	6	M695
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C4A C4B C8B	1.22e-04	17	82	3	MM15944
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CLTCL1 IPO8 POLD1 PSMA2 XPO4 FARSB PSME2 TUBGCP2 EHD4 NUP205 SYNE2 VPS35 EHD1 ANP32A EIF3D ALDH3A2 CPVL STAG2 MRPL1	3.03e-08	1440	101	19	30833792
Pubmed	Defining the membrane proteome of NK cells.	ABCC4 CLTCL1 POLD1 FARSB PSME2 HMMR TUBGCP2 NCDN EHD4 NUP205 LNPEP PI4KA EHD1 IFT122 EIF3D SLC29A1 STAG2	4.39e-08	1168	101	17	19946888
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	IPO8 POLD1 HMMR NCDN EHD4 SH3BP4 AIFM2 SACS ERAP2 LNPEP PI4KA SF3B6 SYNE2 VPS35 VPS13A ANKRD11 IFT122 ALDH3A2 MRPL1	5.01e-08	1487	101	19	33957083
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	CNNM2 RNGTT IPO8 POLD1 PSMA2 XPO4 FARSB NUP205 MTMR4 LNPEP SHCBP1 VPS35 ALDH3A2 CPVL SORL1	1.45e-07	974	101	15	28675297
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	ACACB POLD1 HMMR USP9Y VPS13D VPS35 MEPCE ANKRD11 C4A C4B HYDIN	2.27e-07	497	101	11	36774506
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	ABCC4 SH3BP4 VPS13D LNPEP PI4KA SYNE2 VPS35 VPS13A GCC1 ALDH3A2 SLC29A1	2.61e-07	504	101	11	34432599
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SETX HMMR NCDN SH3BP4 AIFM2 PSME4 SHCBP1 C4A C4B IFT122 IQGAP3 SORL1	4.31e-07	650	101	12	38777146
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	RNGTT IPO8 PSMA2 MRPL55 FARSB PSME2 NCDN MORF4L1 ANP32A EIF3D ALDH3A2 IQGAP3 MRPL1 KIF22	8.59e-07	971	101	14	33306668
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	RNGTT ZDBF2 ZFHX4 SHCBP1 ANP32A MEPCE IQGAP3 MRPL1	1.78e-06	282	101	8	23667531
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	ARHGAP24 IPO8 FGD2 PSMA2 ARHGEF10L NUP205 SF3B6 SHCBP1 ANP32A EIF3D CPVL FGD6 SORL1	2.60e-06	916	101	13	32203420
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	TDRD15 SETX RNGTT ACACB EFCAB6 MKS1 SH3BP4 SLFN13 PI4KA EHD1 VPS13A GCC1	2.75e-06	777	101	12	35844135
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	RNGTT IPO8 POLD1 PSMA2 XPO4 HMMR MKS1 NUP205 SH3BP4 SF3B6 IFT122 EIF3D FGD6 IQGAP3 SORL1	6.35e-06	1321	101	15	27173435
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SETX RNGTT ACTR5 POLD1 FARSB HMMR LNPEP PI4KA MORF4L1 SF3B6 ANKRD11 EIF3D ALDH3A2 IQGAP3 STAG2 KIF22	6.47e-06	1497	101	16	31527615
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	RNGTT IPO8 PSMA2 MRPL55 FARSB PSME2 NUP205 MORF4L1 SHCBP1 VPS35 ANP32A EIF3D ALDH3A2 CPVL MRPL1	7.20e-06	1335	101	15	29229926
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	8.35e-06	2	101	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	8.35e-06	2	101	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	8.35e-06	2	101	2	15998580
Pubmed	Eps15 Homology Domain Protein 4 (EHD4) is required for Eps15 Homology Domain Protein 1 (EHD1)-mediated endosomal recruitment and fission.	EHD4 EHD1	8.35e-06	2	101	2	32966336
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	8.35e-06	2	101	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	8.35e-06	2	101	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	8.35e-06	2	101	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	8.35e-06	2	101	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	8.35e-06	2	101	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	8.35e-06	2	101	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	8.35e-06	2	101	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	8.35e-06	2	101	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	8.35e-06	2	101	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	8.35e-06	2	101	2	12207352
Pubmed	EHD proteins are associated with tubular and vesicular compartments and interact with specific phospholipids.	EHD4 EHD1	8.35e-06	2	101	2	17097635
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	8.35e-06	2	101	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	8.35e-06	2	101	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	8.35e-06	2	101	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	8.35e-06	2	101	2	22387014
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	8.35e-06	2	101	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	8.35e-06	2	101	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	8.35e-06	2	101	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	8.35e-06	2	101	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	8.35e-06	2	101	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	8.35e-06	2	101	2	23918728
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	8.35e-06	2	101	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	8.35e-06	2	101	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	8.35e-06	2	101	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	8.35e-06	2	101	2	4216347
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	8.35e-06	2	101	2	1699796
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	8.35e-06	2	101	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	8.35e-06	2	101	2	2997024
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	8.35e-06	2	101	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	8.35e-06	2	101	2	3624865
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	8.35e-06	2	101	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	8.35e-06	2	101	2	21857912
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	8.35e-06	2	101	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	8.35e-06	2	101	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	8.35e-06	2	101	2	4514997
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	8.35e-06	2	101	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	8.35e-06	2	101	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	8.35e-06	2	101	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	8.35e-06	2	101	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	8.35e-06	2	101	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	8.35e-06	2	101	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	8.35e-06	2	101	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	8.35e-06	2	101	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	8.35e-06	2	101	2	34358307
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	8.35e-06	2	101	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	8.35e-06	2	101	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	8.35e-06	2	101	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	8.35e-06	2	101	2	29080553
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	8.35e-06	2	101	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	8.35e-06	2	101	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	8.35e-06	2	101	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	8.35e-06	2	101	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	8.35e-06	2	101	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	8.35e-06	2	101	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	8.35e-06	2	101	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	8.35e-06	2	101	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	8.35e-06	2	101	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	8.35e-06	2	101	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	8.35e-06	2	101	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	8.35e-06	2	101	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	8.35e-06	2	101	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	8.35e-06	2	101	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	8.35e-06	2	101	2	16908004
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	8.35e-06	2	101	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	8.35e-06	2	101	2	7365238
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	8.35e-06	2	101	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	8.35e-06	2	101	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	8.35e-06	2	101	2	17506029
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	8.35e-06	2	101	2	17971360
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	8.35e-06	2	101	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	8.35e-06	2	101	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	8.35e-06	2	101	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	8.35e-06	2	101	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	8.35e-06	2	101	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	8.35e-06	2	101	2	6881182
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	8.35e-06	2	101	2	3944109
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	8.35e-06	2	101	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	8.35e-06	2	101	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	8.35e-06	2	101	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	8.35e-06	2	101	2	35898513
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	8.35e-06	2	101	2	33353966
Pubmed	Frameshift mutations of vacuolar protein sorting genes in gastric and colorectal cancers with microsatellite instability.	VPS35 VPS13A	8.35e-06	2	101	2	21733561
Interaction	S1PR4 interactions	ABCC4 IPO8 NUP205 CELSR2 LNPEP PI4KA SLC29A1	5.81e-06	137	101	7	int:S1PR4
Cytoband	2p16.2	TSPYL6 PSME4	1.71e-04	9	101	2	2p16.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16q11	SHCBP1 VPS35	3.12e-04	12	101	2	chr16q11
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	FGD2 MTMR4 FGD6	2.62e-04	31	73	3	81
GeneFamily	Complement system\|Sushi domain containing	C4A C4B C8B	4.10e-04	36	73	3	492
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	C4A C4B SLC29A1	4.45e-04	37	73	3	454
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	5.68e-04	9	73	2	1234
GeneFamily	Proteasome	PSMA2 PSME2 PSME4	6.94e-04	43	73	3	690
GeneFamily	Aminopeptidases\|CD molecules	ERAP2 LNPEP	2.10e-03	17	73	2	104
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	FGD2 ARHGEF10L FGD6	2.41e-03	66	73	3	722
ToppCell	severe-Myeloid-Immature_Neutrophils_2\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	VRK1 CLTCL1 SUCNR1 SACS SLFN13 SHCBP1 IQGAP3 KIF22	1.74e-08	198	101	8	844f534551483c89ef789d1cfeb4680e54f794b2
ToppCell	severe-Myeloid-Immature_Neutrophils_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	VRK1 CLTCL1 SUCNR1 SACS SLFN13 SHCBP1 IQGAP3 KIF22	1.74e-08	198	101	8	e36303628af3139310c1d7a84d2919b7319bbda4
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	SETX SYTL2 RAPGEF1 USP9Y SLFN13 LNPEP SYNE2	3.73e-07	200	101	7	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_ALM_Oprk1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ABCC4 EFCAB6 ADAMTS3 ITGA8 HS3ST2 IQGAP3	1.90e-06	162	101	6	2d28306c6125b31f11ea6d911a167b93a74907c5
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGD2 ZDBF2 HMMR SHCBP1 IQGAP3 KIF22	2.78e-06	173	101	6	6c9ecf77d2fb0f89100fdd7e4e88f85598278bc7
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c11-MKI67-FOS\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	VRK1 HMMR MKS1 IFT122 SLC29A1 KIF22	3.60e-06	181	101	6	6873c1138b28c130637d06b64981ad11c262e85f
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP24 ADAM18 HMMR SHCBP1 IQGAP3 KIF22	3.60e-06	181	101	6	b203b616584cdbd0bbb0e382b2916d0bd49d3526
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP24 ADAM18 HMMR SHCBP1 IQGAP3 KIF22	3.60e-06	181	101	6	c748c16fd20d1949d33ff6290dc9d9016c4dc86c
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMMR CELSR2 SHCBP1 C4A SLX4 KIF22	3.72e-06	182	101	6	39f9b3eb22293cc27c6e175702c77d1eeb24fdc9
ToppCell	P28-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ACE EHD4 ST3GAL6 EHD1 ANP32A HYAL2	3.72e-06	182	101	6	db5d6c5e7d59734653906b126f2c1d57461a5290
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 CNNM1 ST3GAL6 LNPEP DNAH17 ALDH3A2	3.84e-06	183	101	6	83592c332b1e82673f993d37c7f480befdc3dcda
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGA8 HMMR GCNT4 CNNM1 IQGAP3 KIF22	3.96e-06	184	101	6	d1e0e3b0eed2db8a5b7e3d6f81294667e4ba64e5
ToppCell	390C-Myeloid-Macrophage\|390C / Donor, Lineage, Cell class and subclass (all cells)	FGD2 LY96 SUCNR1 ACE ARHGEF10L C8B	4.76e-06	190	101	6	f933d971f092c4e56e9f670a9205b688c8b1ca28
ToppCell	droplet-Lung-30m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l12-14\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VRK1 HMMR NUP205 SHCBP1 IQGAP3 KIF22	5.06e-06	192	101	6	52d0aa51e3b6ab3608a5f40bdde9f8134b3afd94
ToppCell	Monocytes-Tissue-resident_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	ABCC4 ARHGAP24 ADGRB3 SH3BP4 ST3GAL6 SORL1	5.21e-06	193	101	6	198552810dcac8d0ca63a78badd6702b49ff6edf
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP24 ADAMTS3 ADAM18 SYTL2 EHD4 ANO7	5.21e-06	193	101	6	6a9bce5064938b5b84ad57b4fd4a7841afe100c8
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC4 ERBB4 SYTL2 SYNE2 CPVL HYDIN	5.36e-06	194	101	6	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	HMMR SLFN13 SHCBP1 C8B SLC29A1 IQGAP3	5.69e-06	196	101	6	34bd155e6d848eb53d613997c0e244535de30ba3
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYTL2 ZDBF2 LNPEP SYNE2 VPS13A ANKRD11	5.86e-06	197	101	6	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYTL2 USP9Y SLFN13 SYNE2 VPS13A ANKRD11	6.21e-06	199	101	6	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells-Neuroepithelial_cell\|10w / Sample Type, Dataset, Time_group, and Cell type.	VRK1 HMMR SHCBP1 SYNE2 IQGAP3 KIF22	6.39e-06	200	101	6	8f8b8c225cdc79baf16fe04be89bdb65e404a055
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells\|10w / Sample Type, Dataset, Time_group, and Cell type.	VRK1 HMMR SHCBP1 SYNE2 IQGAP3 KIF22	6.39e-06	200	101	6	a1f48eca9efb4f3ec3c9ace20f8c9257dd72c4ed
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ARHGAP24 FGD2 SHCBP1 CPVL SLC29A1 IQGAP3	6.39e-06	200	101	6	a1503bcc774bed9563eda7cf90b8b5bf4405ad85
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ARHGAP24 FGD2 SHCBP1 CPVL SLC29A1 IQGAP3	6.39e-06	200	101	6	25247f8b6ba6cd899ba6bd47e28e090d697e4632
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Sla\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADAMTS3 ITGA8 HMMR SH3BP4 ZFHX4	1.27e-05	132	101	5	ddebc0b233fdbb73ceb70187945bbed8fd273f2a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TDRD15 ARHGEF10L SHCBP1 ANP32A SLX4	1.69e-05	140	101	5	e64f6aa57bc069cfe970089bd1c298433bfaf771
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_2\|367C / Donor, Lineage, Cell class and subclass (all cells)	POLD1 HMMR SUCNR1 SHCBP1 IQGAP3	3.62e-05	164	101	5	0662cd9d21608efacc336e0a582859f3b9a4951d
ToppCell	droplet-Lung-LUNG-30m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGD2 ZDBF2 MTMR4 IQGAP3 KIF22	4.06e-05	168	101	5	0e8b0e6399c6c82c9c0e546f7316f902de0765d3
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGA8 HMMR CYP46A1 SHCBP1 KIF22	4.17e-05	169	101	5	563c267edaade0e5df192ad953801ef9768d4270
ToppCell	normal_Pleural_Fluid-Myeloid_cells-CD163+CD14+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	ZDBF2 GCNT4 FSIP2 SYNE2 VPS13A	4.17e-05	169	101	5	bea8aba1f3cc3d0e8d448c1c45f5354d26ebf850
ToppCell	mild-Myeloid-Eosinophils\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ACACB SLFN13 SYNE2 HS3ST2 SLC29A1	4.41e-05	171	101	5	5c8198182495bda7a826e9d80aa467f4eb1094ec
ToppCell	356C-Lymphocytic-ILC-ILC-2\|ILC / Donor, Lineage, Cell class and subclass (all cells)	XPO4 SUCNR1 DNAH17 CPVL SLC29A1	4.54e-05	172	101	5	4977e1f4deae781750e27a8054deccd336cfb74a
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P2-Tnr\|Thalamus / BrainAtlas - Mouse McCarroll V32	CHST5 ADAM18 SHCBP1 CPVL	4.61e-05	87	101	4	0c3a3ed1f279ed29a0113cc73ae590157a4b7334
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	CHST5 ADAM18 SHCBP1 CPVL	4.61e-05	87	101	4	5d1dbbd86d82cbce4f2a3365242eb92d9c821a9e
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P2\|Thalamus / BrainAtlas - Mouse McCarroll V32	CHST5 ADAM18 SHCBP1 CPVL	4.61e-05	87	101	4	a93dbe73b337cc2d93208822728b9badf30b6870
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)\|Thalamus / BrainAtlas - Mouse McCarroll V32	CHST5 ADAM18 SHCBP1 CPVL	4.61e-05	87	101	4	45ef27ba84f731e4b2188813cd6931950e5164ac
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	HMMR LCT SHCBP1 CPVL IQGAP3	4.79e-05	174	101	5	a75ba49ccea6bd3d78ada1092b46deb5202c58a5
ToppCell	droplet-Lung-18m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SYTL2 HMMR SHCBP1 IQGAP3 KIF22	5.06e-05	176	101	5	b17317ac41d3215db55a38cbd3366c0947f7a2a3
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGA8 HMMR SHCBP1 IQGAP3 KIF22	5.06e-05	176	101	5	45c6983ab671b0f306e7390320bd84f848e474cc
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 CNNM1 ST3GAL6 LNPEP DNAH17	5.48e-05	179	101	5	55bc69f107fc710db7617c428575792adfdbbcc1
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ARHGAP24 HMMR CPVL SLC29A1 SORL1	5.93e-05	182	101	5	c6b3762ccec326f057819f75fa7fac0145fb7d54
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF10L CNNM1 DNAH17 CPVL HYDIN	6.09e-05	183	101	5	92fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	ABCC4 CNNM1 SYNE2 VPS13A HYDIN	6.25e-05	184	101	5	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	P28-Endothelial\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ACE EHD4 ST3GAL6 ANP32A HYAL2	6.25e-05	184	101	5	b056411f499866097f4322999cfd1e57a3927b78
ToppCell	facs-Diaphragm-Limb_Muscle-18m-Lymphocytic-T_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POLD1 XPO4 HMMR SHCBP1 KIF22	6.25e-05	184	101	5	185b49630da61cbf45c0926d1b992943296d2a54
ToppCell	P28-Endothelial-capillary_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ACE EHD4 ST3GAL6 ANP32A HYAL2	6.57e-05	186	101	5	26a625ca0300055d6af3472aa0bfba59b73db292
ToppCell	proximal-3-Hematologic-Myeloid_Dendritic_Type_1\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FGD2 LY96 B4GALT6 MTMR4 CPVL	6.57e-05	186	101	5	c920dffd24f051b54d8b48f801fffc928d99e135
ToppCell	proximal-Hematologic-Myeloid_Dendritic_Type_1-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FGD2 LY96 B4GALT6 MTMR4 CPVL	6.57e-05	186	101	5	d740aca5dc4240851ba7bc5988c0970d785ad0c2
ToppCell	Tuft\|World / Class top	SUCNR1 B4GALT6 ANO7 C8B CPVL	6.57e-05	186	101	5	f4d83f15ab7b49c0920a322cd832413ece7c9948
ToppCell	proximal-Hematologic-Myeloid_Dendritic_Type_1\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FGD2 LY96 B4GALT6 MTMR4 CPVL	6.57e-05	186	101	5	4ca7f6c043874a0c536f75af5ca24c7c66725e54
ToppCell	droplet-Bladder-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EHD4 MORF4L1 SYNE2 ANKRD11 SORL1	6.74e-05	187	101	5	663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-effector_CD4-positive,_alpha-beta_T_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ACE GCNT4 SYNE2 SENP7 SORL1	6.74e-05	187	101	5	e61c1755531469dd3850c9740474b5ad4e0499c1
ToppCell	Tuft-tuft-2\|World / Class top	SUCNR1 B4GALT6 ANO7 C8B CPVL	6.74e-05	187	101	5	4ec6eee866619dfe13c84f5d2e812bb380d37139
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 ARHGEF10L ST3GAL6 LNPEP DNAH17	6.74e-05	187	101	5	c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell	MatrixFB-Fibroblast-E_(Early_Fibroblastic_progenitor)\|MatrixFB / shred on cell class and cell subclass (v4)	VRK1 HMMR SHCBP1 IQGAP3 KIF22	6.91e-05	188	101	5	b240ea20750ffb825cb5fe41d06c632233406ab6
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Dendritic-Cycling_Dendritic\|lymph-node_spleen / Manually curated celltypes from each tissue	HMMR SH3BP4 SHCBP1 CPVL IQGAP3	6.91e-05	188	101	5	723348a1836a074e068320cb736ce6a953e0038f
ToppCell	kidney_cells-Hypertensive_with+without-CKD\|kidney_cells / Celltypes from Cells and Nuclei per compartment and clinical group	SUCNR1 LNPEP CPVL SLC29A1 SORL1	6.91e-05	188	101	5	90188b60ff893754f7938fe8edab79758827168e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC4 CNNM1 SYNE2 CPVL HYDIN	7.09e-05	189	101	5	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP24 ADAM18 SYTL2 EHD4 ANO7	7.09e-05	189	101	5	e11998c57609c5714705713ac3a32016d6d841dd
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP24 ADAMTS3 ADAM18 SYTL2 EHD4	7.09e-05	189	101	5	5a0fd34928117f162c83ca1b068aa8f7069a6765
ToppCell	390C-Myeloid-Macrophage-FABP4+_Macrophage_2\|390C / Donor, Lineage, Cell class and subclass (all cells)	FGD2 LY96 SUCNR1 ARHGEF10L C8B	7.09e-05	189	101	5	3b5e1a8d5c1e1fa2124f64f212e9c6b8f1b7d7da
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 ARHGEF10L ST3GAL6 LNPEP DNAH17	7.27e-05	190	101	5	1cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADAMTS3 ITGA8 ACE FGD6 HYAL2	7.27e-05	190	101	5	06bfb62b94b0faf467ef93d5bc5d08924c770098
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SETX ACACB SUCNR1 SLC29A1 IQGAP3	7.27e-05	190	101	5	63018acb7ad80415e861643162abdc2e55968ee4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ERBB4 ARHGAP24 SYTL2 CPVL HYDIN	7.27e-05	190	101	5	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 ARHGEF10L ST3GAL6 LNPEP DNAH17	7.27e-05	190	101	5	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	FGD2 LY96 ACE C8B CPVL	7.27e-05	190	101	5	6514f00d222eef08c282face7f177259bca62f0e
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	VRK1 HMMR SHCBP1 IQGAP3 KIF22	7.27e-05	190	101	5	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_NK-Cycling_NK\|lymph-node_spleen / Manually curated celltypes from each tissue	HMMR B4GALT6 SLFN13 SHCBP1 IQGAP3	7.27e-05	190	101	5	451eaceb0cb0ec6cfcae00253c0e5c92a168c2f3
ToppCell	Endothelial-D_(cycle)\|World / shred on cell class and cell subclass (v4)	HMMR SHCBP1 SLC29A1 IQGAP3 KIF22	7.45e-05	191	101	5	49a4d8f181558e3be9527a8ff9a178f3bb01323c
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HMMR SHCBP1 C8B CPVL IQGAP3	7.45e-05	191	101	5	d6e158f16a183c9203c057192342e9b83e79bc89
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HMMR SHCBP1 C8B CPVL IQGAP3	7.45e-05	191	101	5	7cb5c6f2cf27f3503d1b313e402a7410dfe6473e
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2\|356C / Donor, Lineage, Cell class and subclass (all cells)	HMMR SHCBP1 C8B SLC29A1 IQGAP3	7.45e-05	191	101	5	a2c235a55094e4fd5273d764c9e2967116b48c23
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADGRB3 RAPGEF1 EHD4 SYNE2 HYAL2	7.64e-05	192	101	5	27ff3621e177e7932dd44dd6baa81551ea75a874
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB4 ACACB SYTL2 B4GALT6 SORL1	7.64e-05	192	101	5	e19e3e8edcc08e4a67873bfb6e46489ca6c8756a
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB4 ACACB SYTL2 B4GALT6 SORL1	7.64e-05	192	101	5	61c2caf6c838132ed5faa8791c288f2149eba2c8
ToppCell	P07-Endothelial-proliferative_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HMMR SHCBP1 SLC29A1 IQGAP3 KIF22	7.82e-05	193	101	5	1e95ef29357969ee385b4717c0b5a497390ac260
ToppCell	Severe_COVID-19-Myeloid-proliferating_Myeloid_cells\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	ADGRB3 HMMR SHCBP1 IQGAP3 KIF22	7.82e-05	193	101	5	0d85025690c9cd545cba30abc38acbdd6a39b153
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYTL2 USP9Y LNPEP SYNE2 VPS13A	7.82e-05	193	101	5	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	human_hepatoblastoma-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	VRK1 HMMR SHCBP1 IQGAP3 KIF22	7.82e-05	193	101	5	4b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCell	control-Myeloid-Immature_Neutrophils_2\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CLTCL1 SUCNR1 SLFN13 SHCBP1 IQGAP3	7.82e-05	193	101	5	33349830e9eba506470ad3661fad5e5a283d20ca
ToppCell	Fetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FGD2 LY96 SUCNR1 ST3GAL6 CPVL	7.82e-05	193	101	5	2d0dd2671ff27b922eb316f1ed0140353536ef30
ToppCell	droplet-Tongue-nan-24m-Epithelial-proliferating\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VRK1 HMMR SHCBP1 IQGAP3 KIF22	7.82e-05	193	101	5	f20b90e3f3f5c9a1ae51c5ebe6d3adb954a142f2
ToppCell	P07-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HMMR SHCBP1 SLC29A1 IQGAP3 KIF22	7.82e-05	193	101	5	0f21fb8b35f89f4c1c8109d1a4d3d08a452f9edd
ToppCell	P03-Endothelial-proliferative_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HMMR SHCBP1 SLC29A1 IQGAP3 KIF22	8.02e-05	194	101	5	22bcfb0f3f73608feb22c0847ab4d34f87aeede0
ToppCell	(3)_Chondrocytes-(33)_Chondro-prol/rest\|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis	SYTL2 HMMR SHCBP1 IQGAP3 KIF22	8.02e-05	194	101	5	4a207630d72059345b10010f5cfd3b1462458324
ToppCell	BAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADGRB3 HMMR SHCBP1 IQGAP3 KIF22	8.02e-05	194	101	5	cb39850e9577015b6b9834e98c36b412bae7d462
ToppCell	BAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADGRB3 HMMR SHCBP1 IQGAP3 KIF22	8.02e-05	194	101	5	408597c9aa302a44b112c1d612c21fbb0227a82a
ToppCell	BAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ADGRB3 HMMR SHCBP1 IQGAP3 KIF22	8.02e-05	194	101	5	193cc20fefbd795a4ad59e401a95af47d30603e7
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP24 SYTL2 EHD4 ST3GAL6 ANO7	8.02e-05	194	101	5	0797245ebfa389a6f66874cb0f11297f1456e600
ToppCell	P03-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HMMR SHCBP1 SLC29A1 IQGAP3 KIF22	8.02e-05	194	101	5	5e56ce9b9fe0721be3a9e6efe1422599bb867721
ToppCell	BAL-Severe-Myeloid-Myeloid\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADGRB3 HMMR SHCBP1 IQGAP3 KIF22	8.02e-05	194	101	5	2360b5f995b360419de41612368cab9fb61781a1
ToppCell	BAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ADGRB3 HMMR SHCBP1 IQGAP3 KIF22	8.02e-05	194	101	5	903ae11708b0cb24538c6982abd57fe6fa95b8d3
ToppCell	BAL-Severe-Myeloid-Myeloid\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ADGRB3 HMMR SHCBP1 IQGAP3 KIF22	8.02e-05	194	101	5	58406502a8cbcc3037f79a1b6a683df408297ae5
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HMMR SHCBP1 SLC29A1 IQGAP3 KIF22	8.02e-05	194	101	5	3a49c7c86036e09a8cd0114988380d04ad1a26fb
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP24 SYTL2 EHD4 ST3GAL6 ANO7	8.02e-05	194	101	5	0241b4b88d6210b4c1b8aa99db17115b18142f01
ToppCell	COVID-19-T_cells-Cycling_NK/T_cells\|COVID-19 / group, cell type (main and fine annotations)	VRK1 HMMR SHCBP1 IQGAP3 KIF22	8.21e-05	195	101	5	764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	VRK1 HMMR SHCBP1 IQGAP3 KIF22	8.21e-05	195	101	5	926eb3fc5d028be936885bea0654a77db3107234
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-proliferating\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VRK1 HMMR SHCBP1 IQGAP3 KIF22	8.21e-05	195	101	5	b57132802cb977551e214880984f3edcd375474f
ToppCell	VE-granulo1-\|VE / Condition, Cell_class and T cell subcluster	FGD2 LY96 ARHGEF10L ST3GAL6 CPVL	8.41e-05	196	101	5	ab3f2ce294c7e503d86254a195be0cf500a2c5e4
Disease	endoplasmic reticulum aminopeptidase 2 measurement	ERAP2 LNPEP	1.09e-05	2	98	2	EFO_0801566
Disease	esterified cholesterol measurement, low density lipoprotein cholesterol measurement	TDRD15 ADAMTS3 CELSR2	1.26e-05	14	98	3	EFO_0004611, EFO_0008589
Disease	Colorectal Carcinoma	ABCC4 POLD1 PSMA2 LY96 NCDN ARHGEF10L SACS ANP32A VPS13A SLC29A1 SORL1	2.19e-05	702	98	11	C0009402
Disease	autosomal recessive spinocerebellar ataxia 4 (implicated_via_orthology)	VPS13D VPS13A	3.27e-05	3	98	2	DOID:0111611 (implicated_via_orthology)
Disease	hydrocephalus (implicated_via_orthology)	CELSR2 ULK4 HYDIN	3.31e-05	19	98	3	DOID:10908 (implicated_via_orthology)
Disease	response to statin	TDRD15 RNGTT ADGRB3 CELSR2	3.68e-05	56	98	4	GO_0036273
Disease	longevity, healthspan, parental longevity	HYKK CELSR2 FGD6	1.22e-04	29	98	3	EFO_0004300, EFO_0007796, EFO_0009762
Disease	Complement deficiency disease	C4A C4B C8B	1.80e-04	33	98	3	C0272242
Disease	Cerebral ventriculomegaly	IFT122 HYDIN	2.27e-04	7	98	2	C1531647
Disease	Hydrocephalus Ex-Vacuo	IFT122 HYDIN	2.27e-04	7	98	2	C0270720
Disease	Communicating Hydrocephalus	IFT122 HYDIN	2.27e-04	7	98	2	C0009451
Disease	endoplasmic reticulum aminopeptidase 1 measurement	ERAP2 LNPEP	2.27e-04	7	98	2	EFO_0008119
Disease	Fetal Cerebral Ventriculomegaly	IFT122 HYDIN	2.27e-04	7	98	2	C2936718
Disease	Post-Traumatic Hydrocephalus	IFT122 HYDIN	2.27e-04	7	98	2	C0477432
Disease	Obstructive Hydrocephalus	IFT122 HYDIN	2.27e-04	7	98	2	C0549423
Disease	aspirin use measurement	TDRD15 CELSR2 FGD6	2.98e-04	39	98	3	EFO_0007013
Disease	esterified cholesterol measurement, intermediate density lipoprotein measurement	TDRD15 CELSR2	3.02e-04	8	98	2	EFO_0008589, EFO_0008595
Disease	severe pre-eclampsia (is_marker_for)	ERAP2 LNPEP	3.02e-04	8	98	2	DOID:13129 (is_marker_for)
Disease	Congenital Hydrocephalus	IFT122 HYDIN	3.02e-04	8	98	2	C0020256
Disease	mesangial proliferative glomerulonephritis (biomarker_via_orthology)	ITGA8 RAPGEF1	3.02e-04	8	98	2	DOID:4783 (biomarker_via_orthology)
Disease	Aqueductal Stenosis	IFT122 HYDIN	3.02e-04	8	98	2	C2936786
Disease	Hydrocephalus	IFT122 HYDIN	3.87e-04	9	98	2	C0020255
Disease	triglycerides in large LDL measurement	TDRD15 CELSR2 SYNE2	3.98e-04	43	98	3	EFO_0022319
Disease	coronary artery disease, factor VII measurement	TDRD15 CNNM2 CELSR2 MORF4L1	5.22e-04	111	98	4	EFO_0001645, EFO_0004619
Disease	brain aneurysm	CNNM2 HYKK PRDM2 FGD6	5.58e-04	113	98	4	EFO_0003870
Disease	factor VIII measurement, coronary artery disease	TDRD15 CNNM2 CELSR2 MORF4L1	5.58e-04	113	98	4	EFO_0001645, EFO_0004630
Disease	factor XI measurement, coronary artery disease	TDRD15 CNNM2 CELSR2 MORF4L1	5.96e-04	115	98	4	EFO_0001645, EFO_0004694
Disease	von Willebrand factor measurement, coronary artery disease	TDRD15 CNNM2 CELSR2 MORF4L1	6.57e-04	118	98	4	EFO_0001645, EFO_0004629
Disease	triglycerides in LDL measurement	TDRD15 CELSR2 SYNE2	8.67e-04	56	98	3	EFO_0022320
Disease	response to statin, LDL cholesterol change measurement	TDRD15 CELSR2	1.11e-03	15	98	2	EFO_0007804, GO_0036273
Disease	coronary artery disease, plasminogen activator inhibitor 1 measurement	TDRD15 CELSR2 MORF4L1	1.22e-03	63	98	3	EFO_0001645, EFO_0004792
Disease	Antibody Deficiency Syndrome	C4A C8B	1.44e-03	17	98	2	C0003257
Disease	cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	TDRD15 CELSR2	1.44e-03	17	98	2	EFO_0022232
Disease	atrial fibrillation	ERBB4 POLD1 LY96 ZFHX4 SYNE2 SORL1	1.51e-03	371	98	6	EFO_0000275
Disease	very low density lipoprotein cholesterol measurement, esterified cholesterol measurement	TDRD15 CELSR2	1.61e-03	18	98	2	EFO_0008317, EFO_0008589
Disease	tissue plasminogen activator measurement, coronary artery disease	TDRD15 CELSR2 MORF4L1	1.72e-03	71	98	3	EFO_0001645, EFO_0004791
Disease	fibrinogen measurement, coronary artery disease	TDRD15 CNNM2 CELSR2 MORF4L1	1.76e-03	154	98	4	EFO_0001645, EFO_0004623
Disease	Paroxysmal atrial fibrillation	ERBB4 ACE SYNE2 SORL1	1.85e-03	156	98	4	C0235480
Disease	familial atrial fibrillation	ERBB4 ACE SYNE2 SORL1	1.85e-03	156	98	4	C3468561
Disease	Persistent atrial fibrillation	ERBB4 ACE SYNE2 SORL1	1.85e-03	156	98	4	C2585653
Disease	Atrial Fibrillation	ERBB4 ACE SYNE2 SORL1	2.03e-03	160	98	4	C0004238
Disease	triglyceride measurement, low density lipoprotein cholesterol measurement	TDRD15 ACACB CELSR2 SYNE2	2.31e-03	166	98	4	EFO_0004530, EFO_0004611
Disease	Immunologic Deficiency Syndromes	C4A C8B	2.64e-03	23	98	2	C0021051
Disease	level of Sphingomyelin (d40:2) in blood serum	ADAMTS3 SYNE2	2.64e-03	23	98	2	OBA_2045181
Disease	mortality	FGD2 HYKK VPS13A HS3ST2	2.69e-03	173	98	4	EFO_0004352
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	FGD2 MTMR4	2.87e-03	24	98	2	DOID:10595 (implicated_via_orthology)
Disease	airway responsiveness measurement	ABCC4 IPO8	2.87e-03	24	98	2	EFO_0006897
Disease	free cholesterol:total lipids ratio, intermediate density lipoprotein measurement	TDRD15 ACACB CELSR2	2.98e-03	86	98	3	EFO_0008595, EFO_0020945
Disease	pulmonary embolism	ABCC4 DNAH17	3.12e-03	25	98	2	EFO_0003827
Disease	TEMPS-A questionnaire	ERBB4 ADGRB3	3.12e-03	25	98	2	EFO_0004783
Disease	Cardiac Arrhythmia	CNNM2 ACE	3.12e-03	25	98	2	C0003811
Disease	large artery stroke, coronary artery disease	CNNM2 CELSR2	3.12e-03	25	98	2	EFO_0001645, EFO_0005524
Disease	Kidney Diseases	CNNM2 ACE IFT122	3.18e-03	88	98	3	C0022658

Protein segments in the cluster

Peptide	Gene	Start	Entry
KLILYPNKNVYQILF	ERICH6B	476	Q5W0A0
YVLVALNQFRYLPLE	ERBB4	86	Q15303
YVESLKRILQDYRNP	ARHGEF10L	331	Q9HCE6
NPYFEYLQIRKKIEE	ANKRD11	2436	Q6UB99
LRPVLYNYLDKNLTV	C4B	851	P0C0L5
RAILQFYPKYVELIN	ACE	796	P12821
LYKNLDLILPTLRNY	ADGRB3	766	O60242
LLPQYLEIYIIVEKA	ADAM18	181	Q9Y3Q7
ILAKLLPQYLDQDLY	ALDH3A2	146	P51648
YRENVFKLLPQLTYL	ANP32A	131	P39687
TLQYILDRYPKDIQE	ACTR5	471	Q9H9F9
LPLDYKLERQYVLAV	CELSR2	671	Q9HCU4
LEVFYKLLRDYEPQL	NUP205	766	Q92621
QLLYKFERPQYAEIL	MORF4L1	271	Q9UBU8
AYIVDGLRQYKQPIL	ACACB	2176	O00763
YYAEDLRLKLPLQEL	ANO7	181	Q6IWH7
VIDQLREFYRPYNIK	HS3ST2	341	Q9Y278
QYLKDYLTRLLVPYV	HYAL2	341	Q12891
YQRYKEELVPFLLKL	nan	481	O00370
LAIQLPEKILIYELY	IFT122	401	Q9HBG6
DLVKLKYLEYRQVPN	MAGEB3	251	O15480
QLLPFLVRYAKTLYE	NCDN	416	Q9UBB6
VPRYLIYDIIKFNSQ	RNGTT	356	O60942
ETIYKNYYRIQLKPE	MEPCE	631	Q7L2J0
ILYPAITKYEKRLQN	FSIP2	526	Q5CZC0
QLYYVKFLSLPEVRQ	CPVL	326	Q9H3G5
YLEIYQEKVLDLLDP	KIF22	176	Q14807
AIEIYLKLYDNPLTN	NAA16	561	Q6N069
LFYIPQIVQALRYDK	PI4KA	1651	P42356
LPGVAYYNKLIDRLQ	LCT	471	P09848
NYFEIQYPLKKLDLV	LNPEP	406	Q9UIQ6
EVYIDLLQKNRTPYV	TUBGCP2	26	Q9BSJ2
LYLRKVLPLEEAYRF	EHD4	31	Q9H223
ETVQRILLEPYKYLL	GGPS1	6	O95749
PLKKIYDVEQLRYQA	IQGAP3	81	Q86VI3
GLEVKPILNYYRENI	ITGA8	616	P53708
QIVALAKILLDPYYR	MTMR4	416	Q9NYA4
LLYEELYNKTKPFQL	HMMR	581	O75330
RLKEYDEPYVLLQNK	ABCC4	1251	O15439
LPVVNYNLLKYICRF	ARHGAP24	256	Q8N264
QIDLPIKRYREYELV	ADAMTS3	31	O15072
EYLKNIIYRFLTLPD	GCC1	721	Q96CN9
KIQLPEYILDFGYII	HYDIN	1591	Q4G0P3
VPLLEKYLYALGQNR	HYKK	181	A2RU49
YIDGLNNLIYRPKIL	B4GALT6	346	Q9UBX8
NNLIYRPKILVDRLY	B4GALT6	351	Q9UBX8
QYLSQVLKESLRLYP	CYP46A1	351	Q9Y6A2
LYFILNDLNKINPVY	DNAH17	3661	Q9UFH2
RLFPQKDIYLVEYSL	GCNT4	36	Q9P109
YLKIVLDTFVYQIPR	EFCAB6	321	Q5THR3
YLILKDPNKQVIRVY	EIF3D	506	O15371
IPRRDLKQLYFNLYI	LY96	66	Q9Y6Y9
NLKRYLLQYFKPVID	ERAP2	721	Q6P179
VQRIPRYELLLKEYI	FGD2	246	Q7Z6J4
RQLYAQKLLPLEEHY	EHD1	26	Q9H4M9
AYVELLIQLKKRYFP	SACS	2921	Q9NZJ4
ESLRKLIQYPYLQAF	SLFN13	81	Q68D06
YYLEQQLAKPLLRIF	POLD1	956	P28340
EFLQRVKRLPLEYSY	C8B	316	P07358
LRPVLYNYLDKNLTV	C4A	851	P0C0L4
QNLFPLEINRAIYYK	PRDM2	111	Q13029
PFKLEKLVDNYYRLV	PCDHGA1	391	Q9Y5H4
LKILDQYRQKEYVAP	IPO8	306	O15397
TLNPVYNEILRYKIE	SYTL2	691	Q9HCH5
LNDVIIDFYLKYLIL	SENP7	776	Q9BQF6
KDEQYLFLVRVVVPY	SORL1	1901	Q92673
LEQILRPCKFLTYIY	SH3BP4	741	Q9P0V3
LPYALLQEVYKLEDV	SYNE2	4701	Q8WXH0
FYIRYSEIINLKVVP	TDRD15	1821	B5MCY1
NLEELPLNEYREYIK	AIFM2	211	Q9BRQ8
ALNLIYKPYQIRILD	ST3GAL6	216	Q9Y274
EILKYPYLLLHERVN	SETX	116	Q7Z333
FLYRFLPQKIIYLNQ	PSME2	31	Q9UL46
LIENPLLRYVFGYQK	SHCBP1	301	Q8NEM2
VLYKIDVPANRYDLL	FARSB	61	Q9NSD9
LPRLEFYRYYQQLKL	SLC29A1	226	Q99808
LYQKVLLYQPFELRE	SLX4	1766	Q8IY92
RALQFYLDYKPLLIN	CLTCL1	1406	P53675
KEVRFFNLQVLYPLL	CHST5	196	Q9GZS9
LYQRNRPVDYFVLLL	CNNM1	661	Q9NRU3
LYQRNKPVDYFVLIL	CNNM2	676	Q9H8M5
LPQYRLKVDTLFLYE	TRAK2	51	O60296
VYLKRLYPRQIYEVE	MRPL1	86	Q9BYD6
QLEILYEKYLLDSNP	ZFHX4	2571	Q86UP3
FLLTYVLQRPNLQKY	XPO4	96	Q9C0E2
ILLRNLLPYKIAYYI	VPS13A	2111	Q96RL7
SPLDYQYRQEILKLE	MKS1	101	Q9NXB0
FISPEELIKKLQYRY	RAPGEF1	726	Q13905
QAYARLYPVLLVKQD	MRPL55	46	Q7Z7F7
TNLLQLPQYFDLEIY	STAG2	586	Q8N3U4
ELVQYAGNIIPRLYL	VPS35	96	Q96QK1
EVNRILYIRNLPYKI	SF3B6	16	Q9Y3B4
PVIEDRILNQILYYL	FGD6	911	Q6ZV73
RILNQILYYLPQLYE	FGD6	916	Q6ZV73
ILYYLPQLYELNRDL	FGD6	921	Q6ZV73
KRNIFDYYEPLIKQI	ZDBF2	2046	Q9HCK1
RKLAQQYYLVYQEPI	PSMA2	91	P25787
TYELRPYLDLLFQIL	USP9Y	2331	O00507
EIVYNKLLPYAERLD	PSME4	31	Q14997
YLIIKYPFREHLLQK	SUCNR1	121	Q9BXA5
YTEKPLYENLRDILL	VRK1	311	Q99986
NPYFRNKLIVKVYEV	TSPYL6	301	Q8N831
LYQKIRILEKPFEYI	ZNF12	206	P17014
FEAIIQYPILLKDYR	ULK4	911	Q96C45
IRYYFENLKISIPQI	VPS13D	3981	Q5THJ4