Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessbrain development

SLC25A46 FZD1 SETD1A DMRTA2 TAF1 NEUROD2 MAP1S UNCX BAG6 MYO16

6.51e-068594210GO:0007420
GeneOntologyBiologicalProcesshead development

SLC25A46 FZD1 SETD1A DMRTA2 TAF1 NEUROD2 MAP1S UNCX BAG6 MYO16

1.18e-059194210GO:0060322
GeneOntologyBiologicalProcesscentral nervous system development

SLC25A46 FZD1 SETD1A DMRTA2 TAF1 NEUROD2 MAP1S UNCX BAG6 MYO16

1.12e-0411974210GO:0007417
GeneOntologyCellularComponentchromatin

KLF14 FOXD2 FOXI2 HOXA13 SETD1A DMRTA2 NR2F6 TAF1 NEUROD2 UNCX DSCC1 CENPB AKAP8L

6.94e-0614804413GO:0000785
DomainTF_fork_head_CS_2

FOXD2 FOXI2

4.36e-0346402IPR030456
DomainTF_fork_head_CS_1

FOXD2 FOXI2

4.55e-0347402IPR018122
DomainFORK_HEAD_3

FOXD2 FOXI2

4.94e-0349402PS50039
DomainFH

FOXD2 FOXI2

4.94e-0349402SM00339
DomainFORK_HEAD_1

FOXD2 FOXI2

4.94e-0349402PS00657
DomainFORK_HEAD_2

FOXD2 FOXI2

4.94e-0349402PS00658
DomainForkhead

FOXD2 FOXI2

4.94e-0349402PF00250
DomainFork_head_dom

FOXD2 FOXI2

4.94e-0349402IPR001766
Pubmed

Matrix metalloproteinase-12 leads to elastin degradation in BALB/c mice with eosinophilic meningitis caused by Angiostrongylus cantonensis.

ELN MMP12

1.56e-06244221856305
Pubmed

Remote exosites of the catalytic domain of matrix metalloproteinase-12 enhance elastin degradation.

ELN MMP12

1.56e-06244221967233
Pubmed

Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis.

ELN MMP12

1.56e-06244222223197
Pubmed

Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice.

ELN MMP12

4.69e-06344218479957
Pubmed

BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression.

SETD1A BAG6

4.69e-06344218765639
Pubmed

Heat modulation of tropoelastin, fibrillin-1, and matrix metalloproteinase-12 in human skin in vivo.

ELN MMP12

4.69e-06344215654955
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

KLF14 FOXD2 HOXA13 DMRTA2 NR2F6 NEUROD2 UNCX

5.12e-0654444728473536
Pubmed

DNA-binding specificities of human transcription factors.

KLF14 FOXD2 HOXA13

8.28e-063144323332764
Pubmed

Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues.

COL4A2 ELN

2.34e-05644216192629
Pubmed

Molecular and Genetic Analyses of Collagen Type IV Mutant Mouse Models of Spontaneous Intracerebral Hemorrhage Identify Mechanisms for Stroke Prevention.

COL4A2 TJP1

2.34e-05644225753534
Pubmed

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.

UNCX TJP1

3.27e-05744226114479
Pubmed

Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium.

SLC12A2 TJP1

3.27e-05744211706048
Pubmed

BRN2 as a key gene drives the early primate telencephalon development.

NEUROD2 TJP1

4.36e-05844235245119
Pubmed

Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice.

HOXA13 UNCX

6.99e-051044235977544
Pubmed

Rasd1 interacts with Ear2 (Nr2f6) to regulate renin transcription.

NR2F6 CENPB

8.54e-051144221247419
Pubmed

Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms.

ELN MMP12

1.21e-041344215944607
Pubmed

A census of human transcription factors: function, expression and evolution.

FOXD2 FOXI2 HOXA13 DMRTA2 NR2F6 NEUROD2 UNCX

1.33e-0490844719274049
Pubmed

Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.

ELN MMP12

1.41e-041444216236725
Pubmed

A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34.

COL4A2 MYO16

1.63e-041544216565260
Pubmed

Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex.

DSCC1 CSRP1 HDAC8

1.86e-048744333798452
Pubmed

Type IV collagen drives alveolar epithelial-endothelial association and the morphogenetic movements of septation.

COL4A2 ELN

2.36e-041844227412481
Pubmed

Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos.

HOXA13 UNCX

2.93e-042044219853565
Pubmed

The Wilms tumor gene, Wt1, maintains testicular cord integrity by regulating the expression of Col4a1 and Col4a2.

COL4A2 TJP1

3.24e-042144223325811
Pubmed

FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a.

FZD1 FOXI2

3.24e-042144220171206
Pubmed

CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.

DNAJC7 BAG6 AKAP8L

3.52e-0410844330166453
Pubmed

Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs.

HOXA13 UNCX

3.56e-042244226283362
Pubmed

Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation.

UNCX TJP1

3.56e-042244227870829
Pubmed

SOX9-COL9A3-dependent regulation of choroid plexus epithelial polarity governs blood-cerebrospinal fluid barrier integrity.

SLC12A2 TJP1

3.89e-042344233526661
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

L2HGDH MAP1S DNAJC7 BAG6 AKAP8L

4.01e-0449744536774506
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

SLCO4A1 NR2F6 PROSER2 MAP1S BAG6 AKAP8L

4.09e-0477444615302935
Pubmed

Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair.

ELN MMP12

4.24e-042444228237967
Pubmed

Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate.

FZD1 SLC12A2

4.24e-042444235110543
Pubmed

Neural tube defects by NUAK1 and NUAK2 double mutation.

UNCX TJP1

4.61e-042544222689267
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

SETD1A SLC12A2 TENT4A BAG6

6.58e-0431344438270169
Pubmed

ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.

ELN MMP12

6.65e-043044232882513
Pubmed

Yap and Taz are required for Ret-dependent urinary tract morphogenesis.

UNCX TJP1

7.11e-043144226243870
Pubmed

Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.

MAP1S DNAJC7 MYO16

7.97e-0414344332560809
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

FOXD2 HOXA13 TAF1 DNAJC7 AKAP8L

8.24e-0458344529844126
Pubmed

Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos.

NR2F6 UNCX CSRP1

9.50e-0415244311044609
Pubmed

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.

DNAJC7 BAG6

9.59e-043644235379950
Pubmed

Interaction network of human early embryonic transcription factors.

SETD1A TAF1 AKAP8L NUP54

1.01e-0335144438297188
Pubmed

Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.

ELN TJP1

1.01e-033744234323105
Pubmed

Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter.

FZD1 UNCX

1.07e-033844222833126
Pubmed

Tissue-Specific Actions of Pax6 on Proliferation and Differentiation Balance in Developing Forebrain Are Foxg1 Dependent.

DMRTA2 NEUROD2

1.13e-033944230529950
Pubmed

The von Hippel-Lindau Cullin-RING E3 ubiquitin ligase regulates APOBEC3 cytidine deaminases.

DNAJC7 BAG6

1.18e-034044234004371
Pubmed

The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning.

HOXA13 UNCX

1.18e-034044221256124
GeneFamilyForkhead boxes

FOXD2 FOXI2

2.15e-0343292508
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FZD1 COL4A2 HOXA13 UNCX DSCC1 RCCD1

1.21e-0816144682ed45f144a07856fe92d37426c5f92e259a03a9
ToppCellfacs-Brain_Non-Myeloid-Cerebellum|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 MEDAG SLCO4A1 NEUROD2 UNCX

1.06e-06185445c083a4974590b9ed3ecafedd3e9cdebc5047fe39
ToppCellPND03-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXD2 DSCC1 TENT4A RCCD1

1.57e-05153444489228ab81c3ae339a53a9da6c2a1c1b6ac3f84b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 SSC5D ELN CSRP1

1.97e-051624445f009b231f21861afee9cc0c569082e1135f929c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 SSC5D ELN CSRP1

1.97e-05162444b936f8040dcd4db621ccded19237af8df7d0ed6e
ToppCellIonocyte-iono-1|World / Class top

SLCO4A1 FOXI2 SLC12A2 DUSP8

2.32e-051694444b68bcb4b5fc3cd2db23cd4edace7444aa2d605c
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 SLCO4A1 SSC5D HDAC8

3.23e-051844446b0c110d8930df99043c3b99cf4d873985126960
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 SLCO4A1 SSC5D HDAC8

3.23e-0518444435928fc5f7bbf8c7b09181a2bd27e22dff42ec16
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-Bergmann_glial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 SLCO4A1 SSC5D HDAC8

3.23e-05184444f6148e9591e8845cc62668e49fd52755257cdc7e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MEDAG SLCO4A1 NEUROD2 UNCX

3.30e-05185444cdd75abdaa1ecedfd2e636203b83a6ac1782f0c3
ToppCelldroplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 COL4A2 MEDAG ELN

3.67e-051904448cb950effc449ae59a915132ecc079be54d1acfe
ToppCelldroplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 COL4A2 MEDAG ELN

3.67e-0519044417a73a658fb30a4322b31e38db7b240023738f29
ToppCellP07|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COL4A2 ELN CENPB CSRP1

3.67e-0519044438a613a9bca0ba040c3ada00286d1ce6f83ab23a
ToppCelldroplet-Pancreas-Exocrine-24m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 COL4A2 MEDAG ELN

3.67e-051904445dfbd064ab1f8a0b18b5975c47f8e79697f3db15
ToppCellASK454-Mesenchymal-Fibroblast|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

MEDAG SSC5D ELN CSRP1

3.74e-051914441726add3f392a061536b7aff72ba84303f4a0b1f
ToppCellASK454-Mesenchymal|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

MEDAG SSC5D ELN CSRP1

3.74e-05191444e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCellfacs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 MEDAG SSC5D ELN

3.82e-05192444ac1477433704573f95111eee6263b93668d2845e
ToppCellfacs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 MEDAG SSC5D ELN

3.82e-051924448937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCellfacs-Pancreas-Exocrine-3m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 MEDAG SSC5D ELN

3.82e-05192444e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCelldroplet-Lung-nan-21m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 MEDAG ELN CSRP1

3.82e-05192444e429e8fbc48ad26204a0197b9129e58be56bd7b6
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-endosteal_fibroblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MEDAG HOXA13 SSC5D ELN

3.98e-0519444469362e13158033de44f90f3773db6c0f27de8cb3
ToppCellCOVID-19-lung-Capillary_Aerocytes|lung / Disease (COVID-19 only), tissue and cell type

COL4A2 SLCO4A1 SLC12A2 TJP1

4.14e-051964444ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MEDAG SSC5D ELN IER5L

4.22e-05197444c747c496ac090309b7f8a3e9d840928f12c83f2f
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MEDAG SSC5D ELN IER5L

4.22e-0519744471786e9432e2d649f5d86f639abb25e7102deb67
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MEDAG SSC5D ELN IER5L

4.39e-051994441fd7bbb8727607e6507848602a19bc86882ef2d5
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

COL4A2 SSC5D ELN CSRP1

4.39e-05199444a207b4891881149d4c50721310690fd794157723
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A2 SLCO4A1 NR2F6 BAG6

4.39e-05199444079931e7196719f22a89cfad82f452ec67219ee5
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A2 SLCO4A1 SLC12A2 TJP1

4.39e-0519944414a7c4cf4bb3d43fd32ec9cc74f6625b225ffaa1
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-4|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

COL4A2 MEDAG SSC5D ELN

4.48e-0520044454b18c92daaa3b3368c0c46134b0c27e10c8dbb0
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-CR-CR_Lhx5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DMRTA2 ELN CPT1B

8.44e-05864432990429ed4438f41ff03f4a9cae8863a528fdd81
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-CR|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DMRTA2 ELN CPT1B

8.44e-058644397467708c90a4bd49deafe3e2ec495c56b448ce1
ToppCellStriatum-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Striatum / BrainAtlas - Mouse McCarroll V32

FOXD2 SSC5D MMP12

1.70e-04109443f4b9fe5335cabe48a5fae7ec51bab0d7bdb17321
ToppCellStriatum-Endothelial-ENDOTHELIAL_TIP|Striatum / BrainAtlas - Mouse McCarroll V32

FOXD2 SSC5D MMP12

1.70e-04109443a84a4a3ac19692e5595b9820d49e12ae336f4bbf
ToppCellStriatum-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)-|Striatum / BrainAtlas - Mouse McCarroll V32

FOXD2 SSC5D MMP12

1.70e-04109443f7d7b67f7585f2ae0ac905bcf3980264cf9234b8
ToppCellStriatum-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Striatum / BrainAtlas - Mouse McCarroll V32

FOXD2 SSC5D MMP12

1.70e-04109443f007fa3dc92d6c8543585e47ccec218263b3266e
ToppCellStriatum-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)|Striatum / BrainAtlas - Mouse McCarroll V32

FOXD2 SSC5D MMP12

1.70e-041094438460683529759585bd363d10a16ee13af2bd4e28
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

FOXD2 MEDAG SSC5D

2.99e-04132443560e836764ed7806fb18282dfebe434d30112a9a
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-IPC_like|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

DMRTA2 NEUROD2 UNCX

4.18e-04148443a261c6d3d9cf0311c053fca66c37d39e66db6ad8
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-IPC_like-IPs_and_early_cortical_neurons|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

DMRTA2 NEUROD2 UNCX

4.18e-04148443c0237ba7d4040b6a497094b362dfb8b3a97a7d06
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 ELN CSRP1

4.88e-04156443363f1b661048d25895e2b8681c82894c957b29c0
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 ELN CSRP1

4.88e-04156443d5207dbfbcfb885557ea1378dfe6a56d7102e94a
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FZD1 COL4A2 SSC5D

4.97e-04157443b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL4A2 ELN CSRP1

5.06e-0415844384c0a215dabf697ada036c2b9592d0c61b5077de
ToppCellLPS-antiTNF-Endothelial-Mes-Like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC25A46 COL4A2 CENPB

5.06e-0415844350df52d64d07178975563abd98ce4fddb9f2f7ef
ToppCell21-Trachea-Epithelial-Submucosal_gland_basal|Trachea / Age, Tissue, Lineage and Cell class

FZD1 COL4A2 MYO16

5.16e-041594434f670b57b8d3b090ea2f1aafe15baf93cb7ef146
ToppCellNS-critical-LOC-Myeloid-Basophil|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FZD1 SSC5D MYO16

5.25e-041604438a4746463ca1976f7d6de803496c851249ced797
ToppCellVE-CD8-naive_CD4|VE / Condition, Cell_class and T cell subcluster

SETD1A SLC12A2 DUSP8

5.25e-04160443255d2a150bfe19ee3d4d34533feb9c37ce73d225
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

SSC5D ELN CSRP1

5.25e-04160443d783d29150033e9181c0e30870070268fed3fd85
ToppCellfacs-Lung-Endomucin-24m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLF14 NR2F6 SLC12A2

5.54e-0416344304152557aae230e9587fcc16cbabf1247cc5b419
ToppCellfacs-Lung-Endomucin-24m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLF14 NR2F6 SLC12A2

5.54e-041634430644eb8a66d4e944063125c423de66d2393388b1
ToppCell367C-Myeloid-Monocyte-CD16+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

SLCO4A1 L2HGDH SSC5D

5.64e-041644431aff83fc73b4e41e6f0d4b04dbca153bcc7a3518
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

FOXD2 MEDAG SSC5D

5.74e-04165443570483b43ccb5831feec9337b4664814431d40b1
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

FOXD2 MEDAG SSC5D

5.74e-041654432026a9a07f4d314cc05c167e491312b373468e46
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-Granular_Neuron_CB_Gabra6|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MEDAG NEUROD2 UNCX

5.85e-04166443ec7bd549bda5f18aca8aebce5ba479a81abbbeda
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells-neuroepithelial-like_cells|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

IER5L RCCD1 CSRP1

5.95e-04167443e488d9c7cf4355959e3833de3bd496c13fc11b1b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MEDAG DMRTA2 CSRP1

5.95e-041674434e58f9bf1e9d47720c871776ec34513ded4de9b7
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231|Adult / Lineage, Cell type, age group and donor

COL4A2 SLCO4A1 SLC12A2

5.95e-041674435af9127bae05768a5164d5708a4ad37edca99324
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MEDAG DMRTA2 CSRP1

5.95e-041674434ae9f2c5df13463709ea880ab035965fd99e7626
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MEDAG CPT1B DSCC1

6.05e-04168443a8958b94ffc3423d56c250796dd253884b46f9d9
ToppCellAdult-Mesenchymal-chondrocyte-D175|Adult / Lineage, Cell type, age group and donor

MEDAG ELN ILVBL

6.05e-0416844314071b961c9bdb54a8259b12a88237b802cbde36
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR2F6 PROSER2 MMP12

6.16e-041694433f8aa6d2f9aa060ae1a0ea3eb47e794099fc2c2c
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR2F6 PROSER2 MMP12

6.16e-0416944326de495c7562e0740689d0f78e803698e3e793db
ToppCellControl-Epithelial_cells-ECM-high_epithelial|Control / group, cell type (main and fine annotations)

COL4A2 TJP1 MYO16

6.26e-04170443e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCellIonocyte|World / Class top

SLCO4A1 FOXI2 SLC12A2

6.26e-04170443d2e592f2a679e6a8d32f2b752d9a3c493e50ced4
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid-macrophage|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR2F6 PROSER2 MMP12

6.26e-04170443670027daec5a10dfa12246f1497b58db21d32a22
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 DSCC1 CSRP1

6.37e-04171443972fab891135bd755d5526cbc5a963200067b0a6
ToppCelldroplet-Spleen-nan-18m-Myeloid-macrophage|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 PROSER2 MMP12

6.37e-041714434a2e6ea9674bf23e8012ef0bb2bf19ce1f55fcd5
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A2 DSCC1 CSRP1

6.37e-041714432a77ed79c6f2e700e789c80451a70ecb31639719
ToppCellAT1-AT2_cells-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

COL4A2 MMP12 ZSWIM5

6.37e-041714430b9912f07393aca889db72b40da08e0bc9bc1e8c
ToppCelldroplet-Spleen-nan-18m-Myeloid-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 PROSER2 MMP12

6.48e-04172443850e4c9e9003807c19695be4b13121b0808a9389
ToppCelldroplet-Spleen-nan-18m-Myeloid|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 PROSER2 MMP12

6.48e-04172443018d8160cfcb7882475620dc678f48a69a0f643e
ToppCellControl-Epithelial_cells-AT1|Control / group, cell type (main and fine annotations)

COL4A2 TJP1 MYO16

6.70e-04174443548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ELN DSCC1 DUSP8

6.70e-041744439f2e253694eb5860c00528fda31c305c6de8a2a1
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FZD1 SSC5D ELN

6.81e-041754431799a7be623dc3bf53ba580a7c47d2619969d708
ToppCellmetastatic_Lymph_Node-Endothelial_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

COL4A2 MEDAG ELN

7.04e-0417744371bf5d4bc67bda37a0499e5ec01af7dd5254041d
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KLF14 COL4A2 IER5L

7.04e-04177443452ec2df36c6d656a7cdadc55be545ccdb146a29
ToppCellfacs-Aorta-Heart-24m-Endothelial-aortic_endothelial_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 IER5L CSRP1

7.16e-041784438017aaecd6275d8173c516f6f3a68ea991f3c1b0
ToppCellfacs-Aorta-Heart-24m-Endothelial|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A2 IER5L CSRP1

7.16e-0417844346333db0d205580189062bf9df839c97196ad161
ToppCellCOPD-Stromal-SMC|World / Disease state, Lineage and Cell class

COL4A2 ELN CSRP1

7.27e-04179443b2709537ec1b46457ab85261f4cdd354e60a8b29
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL4A2 TJP1 MYO16

7.27e-041794434f6ca313b78aa93557937a046c44dcf8bcc9963c
ToppCellCOPD-Stromal-SMC|COPD / Disease state, Lineage and Cell class

COL4A2 ELN CSRP1

7.27e-041794435c705627bd13a5b2c7b0062fb3d94e4eb1589327
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLF14 FZD1 COL4A2

7.27e-0417944356db12467b445f2b8ef92af50779eeab10413eb2
ToppCellfacs-Kidney-nan-24m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MEDAG SSC5D DSCC1

7.39e-04180443f9f8245cbcdea18c15e2976c85b72c6807309787
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-Granular_Neuron_CB_Gabra6|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MEDAG NEUROD2 UNCX

7.39e-04180443d76349ecef7c5878bf215e946f032264161eb61b
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MEDAG NEUROD2 UNCX

7.39e-041804433d54cc767e25d91ed2203d8a03e5bf5e15f21699
ToppCellLPS-antiTNF-Endothelial-Endothelial-Alv_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL4A2 SLC12A2 TJP1

7.39e-0418044330cf3c7ee29694eaccb89bf8053a82037d5c9f1d
ToppCellCOVID-19-Endothelial_cells-Capillary_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

COL4A2 SLCO4A1 SLC12A2

7.51e-04181443c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FOXD2 SSC5D ELN

7.51e-04181443b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCellfacs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MEDAG SSC5D DSCC1

7.51e-041814430ec9621a078d004bbd25a587757d24b5cf162959
ToppCell18-Airway-Epithelial-Submucosal_gland_basal|Airway / Age, Tissue, Lineage and Cell class

COL4A2 NEUROD2 CSRP1

7.51e-0418144333938e6521712058312879f84f4ae381c2bfc379
ToppCellfacs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MEDAG SSC5D DSCC1

7.51e-04181443c7f5aedcb74c21fb587a95a16d700e2a38a380ee
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SSC5D ELN CSRP1

7.51e-04181443d7e04e0ca549eac6d9b1192b6578f9b54943d54f
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FOXD2 TJP1 CSRP1

7.63e-04182443cde8fa4f42d25545abaa9ee885b4b1e24a5a8e08
ToppCelldroplet-Kidney-nan-18m-Epithelial-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLF14 PROSER2 UNCX

7.63e-041824439fc2f84bf70ad9a11c8a7326bd101e6f6cbcc33e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 SLCO4A1 HDAC8

7.63e-04182443904804813849b7f7f716ba1554d33b07bc0a701e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 SLCO4A1 HDAC8

7.63e-041824435d8b7fe18286e27f0f50c5d2d9be56850e2cb8f4
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MEDAG SSC5D ELN

7.63e-04182443d179b5deb07c20d49eb6c58d5a65904f8921de3a
ToppCellfacs-Heart-LV-18m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLCO4A1 NR2F6 DSCC1

7.63e-041824436dff753d65ba45db81f3cc0c9f59e1779d490955
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-Bergmann_glial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD1 SLCO4A1 HDAC8

7.75e-0418344399bb4ceb92f6467f2359a42ab2cff6df18825a30
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MEDAG SSC5D ELN

7.75e-041834432beb5414958d38a5341870d55229f3b1707e76bf
DiseaseFocal Emphysema

ELN MMP12

1.36e-0412432C2350878
DiseaseCentriacinar Emphysema

ELN MMP12

1.36e-0412432C0221227
DiseasePanacinar Emphysema

ELN MMP12

1.36e-0412432C0264393
Diseaseabdominal aortic aneurysm (is_implicated_in)

ELN MMP12

1.36e-0412432DOID:7693 (is_implicated_in)
DiseasePulmonary Emphysema

ELN MMP12

2.78e-0417432C0034067
DiseaseEpilepsy

L2HGDH SETD1A SLC12A2

5.43e-04109433C0014544
Diseaseschizophrenia, type 2 diabetes mellitus

SLCO4A1 NEUROD2

1.80e-0343432MONDO_0005090, MONDO_0005148
DiseaseMyocardial Ischemia

ELN CPT1B FEZ2

2.16e-03176433C0151744

Protein segments in the cluster

PeptideGeneStartEntry
EPGADGALGFFGALL

BAG6

741

P46379
FSPEGAQGAGGVLFA

DUSP8

526

Q13202
GFPGSKGEAGFFGIP

COL4A2

941

P08572
VFGSVCAADGGGPGA

DMRTA2

156

Q96SC8
AFPGGSRFGFGFGNG

AKAP8L

241

Q9ULX6
PGAWFGFGFCGFGQE

RCCD1

6

A6NED2
GFGFCGFGQELGSGR

RCCD1

11

A6NED2
FGAGGGAAGAVLGID

NR2F6

186

P10588
LAHAFGPGSGIGGDA

MMP12

181

P39900
FPGGLGDAAFFAVNG

MAP1S

246

Q66K74
RGLFAGGSPGACGFA

L2HGDH

16

Q9H9P8
DDGGPGAGSFLLHGA

MYO16

1441

Q9Y6X6
AGGLGTFPGGLAGDF

FOXI2

256

Q6ZQN5
GPKGFGFGQGAGALV

CSRP1

176

P21291
FSLFGLGGEPGGGAA

BPNT2

36

Q9NX62
GEPAAARGGFNVFGD

MEDAG

61

Q5VYS4
PGGGRGGAFFNFADG

TENT4A

121

Q5XG87
AATAAPAGGFGGFGT

NUP54

16

Q7Z3B4
GFPGGAGASERGKFS

FZD1

261

Q9UP38
AACFREAGFGGGPNA

CENPB

381

P07199
GAFGTLGVGAGFALG

ILVBL

491

A1L0T0
FGPGASGAAAGDFCL

DSCC1

31

Q9BVC3
AFLFGFGDGGGGPTQ

MAN2C1

456

Q9NTJ4
AFFGGPGGFSFEASG

DNAJC7

471

Q99615
FSGGALGAGPAPAAD

KLF14

166

Q8TD94
GFFPGTGDVSDVGLG

HDAC8

206

Q9BY41
FGAGAAGVLPGVGGA

ELN

266

P15502
AADFGPLQLGGGGDA

IER5L

86

Q5T953
LGAGGGFGPVADDGY

CPT1B

706

Q92523
AGAEAGGGADGFPAP

FEZ2

36

Q9UHY8
GAAAAGDPGAFLPGF

FOXD2

246

O60548
GHAGAFPAAGDAGEG

PROSER2

291

Q86WR7
AGGGPFSLAGFLFGN

TAF1

31

P21675
LGCGGALAAPGGAFF

SSC5D

61

A1L4H1
ALAAPGGAFFGEGAG

SSC5D

66

A1L4H1
GCGGALAAPGGAFFG

SSC5D

346

A1L4H1
LAAPGGAFFGEGSGP

SSC5D

351

A1L4H1
AASAGPPGGAFGEAF

SETD1A

701

O15047
AAAAAAGAGGGGFPH

HOXA13

46

P31271
PAGGGGTFLGGFFVN

SLCO4A1

431

Q96BD0
AGAGAAGCGGEGLPF

ZSWIM5

166

Q9P217
GGARDEQGFGGAFPA

SLC25A46

16

Q96AG3
GPEFGGAIGLIFAFA

SLC12A2

361

P55011
AAPGGGHFGDGDAAI

SCART1

376

Q4G0T1
GFGFGIAISGGRDNP

TJP1

31

Q07157
GAGEGPGGAFARVSD

WASH6P

411

Q9NQA3
GAFSGPGGAPDSAFA

UNCX

426

A6NJT0
ADGAGRFHGSGGPFA

NEUROD2

221

Q15784