Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentciliary membrane

TMEM67 EPS15 GNAT2

3.70e-0498303GO:0060170
GeneOntologyCellularComponentH4/H2A histone acetyltransferase complex

MORF4L2 MSL3

9.61e-0432302GO:0043189
GeneOntologyCellularComponentNuA4 histone acetyltransferase complex

MORF4L2 MSL3

9.61e-0432302GO:0035267
DomainMRG

MORF4L2 MSL3

7.99e-063312PS51640
DomainMRG_dom

MORF4L2 MSL3

7.99e-063312IPR026541
DomainMRG

MORF4L2 MSL3

1.60e-054312PF05712
DomainMRG

MORF4L2 MSL3

1.60e-054312IPR008676
DomainTBC_RABGAP

TBC1D12 TBC1D32

3.75e-0355312PS50086
DomainRab-GTPase-TBC_dom

TBC1D12 TBC1D32

3.75e-0355312IPR000195
Domain-

ARFGEF1 HEATR5A ARMCX1

5.83e-032223131.25.10.10
DomainARM-like

ARFGEF1 HEATR5A ARMCX1

9.96e-03270313IPR011989
Pubmed

The aftiphilin/p200/gamma-synergin complex.

EPS15 HEATR5A

4.21e-051131215758025
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

TBC1D32 GAPVD1 COPA ANAPC1 MORF4L2 HERC5

9.56e-0585731625609649
Pubmed

A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.

COPA ANAPC1

2.10e-042431233705438
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

GAPVD1 MPHOSPH10 COPA ANAPC1 HERC5

2.61e-0465331522586326
Pubmed

Genetic link between renal birth defects and congenital heart disease.

TBC1D32 TMEM67

2.86e-042831227002738
Pubmed

Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway.

ARFGEF1 ANAPC1

3.29e-043031227568566
Pubmed

Interactome Analysis of the Nucleocapsid Protein of SARS-CoV-2 Virus.

MPHOSPH10 MORF4L2 HERC5

3.84e-0415931334578187
Pubmed

Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.

EPS15 GAPVD1 ANAPC1

4.43e-0416731325659891
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

EPS15 GAPVD1 GNAT2 COPA ANAPC1 MSL3

4.78e-04115531620360068
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

TBC1D12 GAPVD1 MPHOSPH10 ANAPC1

6.07e-0444031434244565
Pubmed

Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.

COPA ANAPC1

6.47e-044231227578003
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

CLPTM1L COPA ANAPC1

7.70e-0420231333005030
CytobandEnsembl 112 genes in cytogenetic band chr1p13

ADORA3 GNAT2 PHTF1

3.91e-04211313chr1p13
CytobandEnsembl 112 genes in cytogenetic band chrXq22

MORF4L2 ARMCX1

6.04e-03172312chrXq22
CytobandEnsembl 112 genes in cytogenetic band chr1q23

COPA INSRR

1.02e-02226312chr1q23
GeneFamilyAdenosine receptors|V-set domain containing

ADORA3 SIGLEC11

1.12e-02163182590
CoexpressionDAUER_STAT3_TARGETS_DN

SAMD9 TRANK1 HERC5

2.50e-0548313M13696
CoexpressionGSE15930_STIM_VS_STIM_AND_IL12_72H_CD8_T_CELL_UP

CLPTM1L EPS15 MPHOSPH10 COPA

8.64e-05199314M3639
CoexpressionGSE37416_12H_VS_48H_F_TULARENSIS_LVS_NEUTROPHIL_UP

SAMD9 ATP10D HERC5 PHTF1

8.64e-05199314M5359
CoexpressionGSE32423_MEMORY_VS_NAIVE_CD8_TCELL_IL7_IL4_DN

TMEM168 ARMCX1 KLHL13 MSL3

8.81e-05200314M5081
CoexpressionGSE42021_CD24HI_VS_CD24LOW_TREG_THYMUS_DN

SERPINA4 SAMD9 TRANK1 HERC5

8.81e-05200314M9588
CoexpressionIBRAHIM_NRF1_UP

GAPVD1 MPHOSPH10 TMEM168 ANAPC1 ATP10D

1.24e-04420315M42509
ToppCellPBMC-Control-cDC_1|Control / Compartment, Disease Groups and Clusters

SAMD9 TRANK1 HERC5

1.71e-041563139b6c5bcac516a62bcc1f5be32ffa8c92735ef0bc
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SAMD9 TRANK1 HERC5

1.95e-04163313d005115aa1e1458b51de7eb719794617a4168608
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SAMD9 TRANK1 HERC5

2.20e-0417031307b561cd9c528bc8444c9385e1de621eee7b697e
ToppCell10x5'-blood-Lymphocytic_B_plasma-Plasmablasts|blood / Manually curated celltypes from each tissue

TBC1D12 CLPTM1L GNAT2

2.40e-041753132e048bf7961c3d86b6e12a1ebae3b3f2359af457
ToppCellSevere-CD4+_T_activated|Severe / Disease group and Cell class

SAMD9 TRANK1 HERC5

2.48e-04177313a08f170f1143fcdd7d0842a54d9b807a4548f8b7
ToppCellSevere-CD4+_T_activated|World / Disease group and Cell class

SAMD9 TRANK1 HERC5

2.52e-04178313ef6111238703579a34bd6948bd9d4ca6b7e16063
ToppCellT_cells-ISG-high_CD4+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

SAMD9 TRANK1 HERC5

2.56e-04179313af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCellMild-CD4+_T|World / Disease group and Cell class

SAMD9 TRANK1 HERC5

2.74e-04183313c4ac8893d38a3da4e19fe2ef1756bd69c89e975c
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

SAMD9 TRANK1 HERC5

2.74e-041833138f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SAMD9 TRANK1 HERC5

2.82e-04185313f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCellCOVID-19_Moderate-NK_activated|World / disease group, cell group and cell class

SAMD9 TRANK1 HERC5

2.87e-04186313ff8f32f69516bf785224fa12f8139a95359b0279
ToppCellT_cells-ISG-high_CD4+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

SAMD9 TRANK1 HERC5

2.96e-041883136f8946d4710f6e32c937213f99b790b098b8819c
ToppCellhematopoetic_progenitors-CD34+_MEP_1|World / Lineage and Cell class

ARMCX1 KLHL13 PHTF1

3.10e-0419131391327184ca40bfb8c9e904991b1be503aaccd7bc
ToppCellCalu_3-infected-SARSCoV2|infected / Cell line, Condition and Strain

SAMD9 TRANK1 HERC5

3.10e-041913132da876d26f37a00dbdf1ee79d724306e8b20f304
ToppCellMild/Remission-B_activate-7|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SAMD9 TRANK1 HERC5

3.10e-04191313382686d62f7b8576c44bb9726a4e10dc26fd348e
ToppCellBAL-Mild|BAL / Compartment, Disease Groups and Clusters

SAMD9 TRANK1 HERC5

3.15e-041923131a6cbf014d3f7a3fb6f53adab078c4742e7137de
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Myeloid-Monocytic|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

TBC1D12 SIGLEC11 PHTF1

3.15e-0419231381f93b4c853f176c91b5ddef34238e37047a0e69
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

TBC1D12 SIGLEC11 PHTF1

3.15e-04192313af453a179f3fdd4ae870f1d98a485e8c9fd726ac
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Myeloid-Monocytic-Nonclassical_Monocyte|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

TBC1D12 SIGLEC11 PHTF1

3.15e-04192313176b9c1dd2c91bca46e12fa5060bfe590dc18246
ToppCelldroplet-Pancreas-Endocrine|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COPA MORF4L2 INSRR

3.15e-041923130dfd1e9896c34aee0f842f8de5d0e3af62a15f68
ToppCellMild_COVID-19|World / Disease group,lineage and cell class (2021.01.30)

SAMD9 TRANK1 HERC5

3.20e-04193313325b0768827bf8701bfb7f686bb11fd8b1a41a5c
ToppCelldroplet-Pancreas-Endocrine-21m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COPA MORF4L2 INSRR

3.25e-041943133a3ecedcdc7691cf21775818b598208fcb980c29
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COPA MORF4L2 INSRR

3.25e-041943130b023de48ed8a550d169bbe954881eb04bf4f981
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HEATR5A PANX2 COG6

3.25e-041943130e9830ad070c47acaa952400bf2a3ddbff664a2f
ToppCellMild/Remission-B_activate-7|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SAMD9 TRANK1 HERC5

3.25e-0419431301c97543972159a9468272da06e7e611e2c21fae
ToppCellmild-B_cell|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TBC1D12 TBC1D32 SAMD9

3.30e-041953131e5f1967bcc898318f4e970b844b4a944eb168e5
ToppCellCOVID-19_Moderate-CD8+_T_activated|World / disease group, cell group and cell class

SAMD9 TRANK1 HERC5

3.30e-04195313070c5d3bdbd4ea54a579c01c37fb99bcf823982e
ToppCellB_cells-ISG-high_B_cells|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

SAMD9 TRANK1 HERC5

3.30e-04195313b64d9e1a8834401b4dc501566546647754ae21fc
ToppCellMonocytes-M2-like_CD16+_macrophages|World / Immune cells in Kidney/Urine in Lupus Nephritis

TBC1D12 ADORA3 SIGLEC11

3.30e-0419531310fa47bdcf6c9784ea930b75a5861e139421feed
ToppCellCV-Moderate-1|Moderate / Virus stimulation, Condition and Cluster

SAMD9 TRANK1 HERC5

3.34e-04196313b50cfcd87c5b67806450cb8b3c6860ab97f6d3b1
ToppCellBAL-Mild|BAL / Location, Disease Group, Cell group, Cell class (2021.03.09)

SAMD9 TRANK1 HERC5

3.34e-041963136566e6671257f7df4d3f375e84f0b292ab4bcde1
ToppCellC_05|World / shred on cell type and cluster

SAMD9 PEX26 HERC5

3.34e-04196313bf4dfb460a153dbafb2b9b12b360c8757cec22cd
ToppCellBAL-Mild|BAL / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9 TRANK1 HERC5

3.34e-041963133408d561d29802fca9eff5c54ccf70818d240cea
ToppCellmild-Myeloid-Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SAMD9 TRANK1 HERC5

3.34e-04196313ded44b38ea489946e9eedfe752b5a9fde9149c16
ToppCellMild|World / Disease group and Cell class

SAMD9 TRANK1 HERC5

3.34e-041963135e4ed4a5a437cfa002b92775992a791e27aa4c27
ToppCellMild-CD4+_T_activated|World / Disease group and Cell class

SAMD9 TRANK1 HERC5

3.34e-04196313417b4fc2e4388f34c410576131b02936f93e46b6
ToppCellMild-CD4+_T_activated|Mild / Disease group and Cell class

SAMD9 TRANK1 HERC5

3.34e-04196313daa1c3322d81e649161e889e1d78451d2d425d09
ToppCellMild-CD8+_T_activated|World / Disease group and Cell class

SAMD9 TRANK1 HERC5

3.34e-0419631379632190e44fcef9d7c11d9b9e37f2ebf0e6e255
ToppCellBAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9 TRANK1 HERC5

3.40e-04197313b3876076684781fb8384117f2cf367d828985986
ToppCellCV-Moderate-1|CV / Virus stimulation, Condition and Cluster

SAMD9 TRANK1 HERC5

3.40e-04197313e3d00d850b4d191f9592ef993c0eaadfe5710b5f
ToppCellBAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9 TRANK1 HERC5

3.40e-041973130b4fdf0131dd67a86ee3209fa66db0ca2e01a10e
ToppCellsevere-Myeloid-Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SAMD9 TRANK1 HERC5

3.40e-04197313c8a90d82170cf20e14aebecddcf7cc0ca56cda87
ToppCellMild-CD8+_T_activated|Mild / Disease group and Cell class

SAMD9 TRANK1 HERC5

3.45e-04198313ceac1b51bacfd0dd7fe7c6a666f7927055e1f380
ToppCellCV-Mild-1|CV / Virus stimulation, Condition and Cluster

SAMD9 TRANK1 HERC5

3.45e-041983134b078714c49e7befb7b113d72485e712236d35fa
ToppCellControl-Control-Lymphocyte-T/NK-CD4+_T_activated|Control / Disease, condition lineage and cell class

SAMD9 TRANK1 HERC5

3.45e-04198313ee71543559836fd59adc0da877b2ca538cba60cb
ToppCellTransverse-Macrophage-LYVE1_Macrophage|Transverse / Region, Cell class and subclass

CD164L2 ADORA3 SIGLEC11

3.50e-04199313facf79c256db5ae57bdb613e86ec90616a6f67ca
ToppCellVE-CD4-antiviral_CD4|VE / Condition, Cell_class and T cell subcluster

SAMD9 TRANK1 HERC5

3.50e-04199313056a0538ca5e825ae6195b4c76c208708a014533
ToppCellCOVID-19_Moderate|World / disease group, cell group and cell class

SAMD9 TRANK1 HERC5

3.50e-04199313952fac67588ad5676f5939e3c7f8bac803c27064
ToppCellTransverse-(6)_Macrophage-(61)_LYVE1_Macrophage|Transverse / shred on region, Cell_type, and subtype

CD164L2 ADORA3 SIGLEC11

3.50e-04199313dcc2a7f4d1fa30aaaad655dd59c5a2b039d264bf
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-CD4+_T_activated|COVID-19_Severe / Disease, condition lineage and cell class

SAMD9 TRANK1 HERC5

3.55e-04200313deeed668b129e66156b5f6abe1a07a9bf842a14d
ToppCellBrain_organoid-organoid_Tanaka_cellReport-1m-Macroglial-Glia_progenitor_cell|1m / Sample Type, Dataset, Time_group, and Cell type.

COG6 MORF4L2 HERC5

3.55e-0420031326940eee4a2f2aafd857964b5607e7dfb65f8d6f
ToppCellVE|World / Condition, Cell_class and T cell subcluster

SAMD9 TRANK1 HERC5

3.55e-042003138ae7cb81de3ffac5acdf3466d4b516d80cac95d3
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated|COVID-19_Mild / Disease, condition lineage and cell class

SAMD9 TRANK1 HERC5

3.55e-04200313d9e8a0d047d4403fb7265fde7448e23a7780785c
DiseaseMeckel syndrome (implicated_via_orthology)

TBC1D32 TMEM67

2.98e-058312DOID:0050778 (implicated_via_orthology)
Diseasevisceral heterotaxy (implicated_via_orthology)

TBC1D32 TMEM67

6.95e-0437312DOID:0050545 (implicated_via_orthology)
Diseasesystemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, rheumatoid factor negative, oligoarticular juvenile idiopathic arthritis

COG6 PHTF1

8.13e-0440312EFO_1001999, EFO_1002019, EFO_1002020
DiseaseInfluenza

SAMD9 HERC5

1.37e-0352312C0021400
Diseaserheumatoid arthritis, ACPA-positive rheumatoid arthritis, rheumatoid factor seropositivity measurement

COG6 PHTF1

2.00e-0363312EFO_0000685, EFO_0007791, EFO_0009459

Protein segments in the cluster

PeptideGeneStartEntry
FFEENLSKLFLHFKS

TBC1D12

641

O60347
HFFLIEKKSHLASIF

FAM200B

406

P0CF97
KEKTFQFLHQFSRLL

TBC1D32

1081

Q96NH3
FKTAKSLFLVLFLFA

ADORA3

226

P0DMS8
SIFLTLLSNFKTHLK

ARFGEF1

506

Q9Y6D6
DFAVSQFKHLSKLLL

ATP10D

1086

Q9P241
NLSAFNCLHKFAKDF

ANAPC1

1481

Q9H1A4
LFKLFSEGLFSAKLF

GAPVD1

181

Q14C86
HFFSLPFKKSLLAAL

PEX26

246

Q7Z412
NLKALLKHFDLFLRF

MSL3

476

Q8N5Y2
LHDFLKYLAKNSASL

MORF4L2

256

Q15014
DSLFLKLDALSNFHF

MPHOSPH10

501

O00566
HFPFIFNNLSKIKLL

HERC5

631

Q9UII4
KKIFFNSLSLHASKL

COG6

411

Q9Y2V7
KNFAAFFSHILSLAS

HEATR5A

321

Q86XA9
SLNEKRTFFHLSALK

KLHL13

426

Q9P2N7
LFFKLKNFKTAATFA

COPA

1111

P53621
HSFALVSLGFFKNLK

INSRR

386

P14616
SLQAVAFFVLHFLKA

CD164L2

151

Q6UWJ8
KLSKDQFALAFHLIS

EPS15

276

P42566
HLFIFRKSNFIFDKL

PANX2

311

Q96RD6
AFALKALQFLHKLIS

TMEM67

616

Q5HYA8
FTKEAKLFSFLALLN

SAMD9

911

Q5K651
SALFLSHNLKFLAKF

SERPINA4

141

P29622
HKFFAATSIVLFLNK

GNAT2

256

P19087
DFFALLFLGNHFTKI

ARMCX1

331

Q9P291
FHLLFDFLAFKNDIS

CLPTM1L

296

Q96KA5
SAFDIKCLFNHFLKI

C12orf29

296

Q8N999
KQRFLFAKLFSHITS

PHTF1

556

Q9UMS5
GLSFDTLHSKLKAFL

TMEM168

471

Q9H0V1
KLRDAFFKFDTLNHS

TRANK1

2001

O15050
HSFLSNAFFLKVTAL

SIGLEC11

141

Q96RL6