Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

CRIM1 CSNK1A1 CSNK2A1 MAP3K20 RIOK3 PPP1R9B PIP4K2C CSNK2A3 MUSK CASK

1.74e-057095410GO:0016773
GeneOntologyMolecularFunctionprotein kinase activity

CRIM1 CSNK1A1 CSNK2A1 MAP3K20 RIOK3 PPP1R9B CSNK2A3 MUSK CASK

2.99e-05600549GO:0004672
GeneOntologyMolecularFunctionkinase activity

CRIM1 CSNK1A1 CSNK2A1 MAP3K20 RIOK3 PPP1R9B PIP4K2C CSNK2A3 MUSK CASK

3.30e-057645410GO:0016301
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

CRIM1 CSNK1A1 CSNK2A1 PARP2 MAP3K20 RIOK3 PPP1R9B PIP4K2C CSNK2A3 MUSK CASK

3.47e-059385411GO:0016772
GeneOntologyMolecularFunctionactin filament binding

CYFIP1 SPTBN1 PPP1R9B AIF1L ADD2

3.65e-04227545GO:0051015
GeneOntologyMolecularFunctionprotein serine kinase activity

CSNK1A1 CSNK2A1 MAP3K20 RIOK3 CSNK2A3 CASK

4.29e-04363546GO:0106310
GeneOntologyMolecularFunctionG protein activity

KRAS NRAS HRAS

5.46e-0459543GO:0003925
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

CSNK1A1 CSNK2A1 MAP3K20 RIOK3 CSNK2A3 CASK

1.25e-03446546GO:0004674
GeneOntologyMolecularFunctionactin binding

CYFIP1 MAP1A SPTBN1 PPP1R9B AIF1L ADD2

1.80e-03479546GO:0003779
GeneOntologyMolecularFunctioncysteine-type peptidase activity

LGMN CAPNS2 USP9Y MINDY2

1.80e-03192544GO:0008234
GeneOntologyMolecularFunctionprotein phosphatase regulator activity

CSNK2A1 PDP2 PPP1R9B

2.51e-03100543GO:0019888
GeneOntologyMolecularFunctionGDP binding

KRAS NRAS HRAS

2.73e-03103543GO:0019003
GeneOntologyBiologicalProcesspositive regulation of protein localization to membrane

SPTBN1 HRAS PPP1R9B MTCL1 MUSK

1.71e-05130515GO:1905477
GeneOntologyBiologicalProcessactin filament depolymerization

SPTBN1 PPP1R9B SPECC1L ADD2

2.13e-0566514GO:0030042
GeneOntologyBiologicalProcessregulation of protein localization to membrane

CSNK2A1 SPTBN1 HRAS PPP1R9B MTCL1 MUSK

2.52e-05237516GO:1905475
GeneOntologyBiologicalProcessprotein depolymerization

MAP1A SPTBN1 PPP1R9B SPECC1L ADD2

2.81e-05144515GO:0051261
GeneOntologyBiologicalProcesssmall GTPase-mediated signal transduction

KRAS CYFIP1 NRAS CSNK1A1 DHCR24 HRAS ECT2 MUSK

4.83e-05538518GO:0007264
GeneOntologyBiologicalProcessnegative regulation of protein depolymerization

MAP1A SPTBN1 SPECC1L ADD2

6.93e-0589514GO:1901880
GeneOntologyBiologicalProcesspositive regulation of small GTPase mediated signal transduction

KRAS CSNK1A1 HRAS MUSK

7.89e-0592514GO:0051057
GeneOntologyBiologicalProcesspositive regulation of protein localization

MAP1A SPTBN1 HRAS PPP1R9B MTCL1 ECT2 MUSK CASK

9.31e-05591518GO:1903829
GeneOntologyBiologicalProcessnegative regulation of protein-containing complex disassembly

MAP1A SPTBN1 SPECC1L ADD2

1.09e-04100514GO:0043242
GeneOntologyBiologicalProcessdefense response to protozoan

NRAS HRAS TSPAN32

1.22e-0439513GO:0042832
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

KRAS LGMN CYFIP1 CRIM1 SUDS3 SPTBN1 HRAS PIP4K2C USP9Y MUSK SVEP1

1.23e-0411865111GO:0007167
GeneOntologyBiologicalProcessregulation of cellular component biogenesis

CYFIP1 CSNK1A1 SPTBN1 HRAS RIOK3 PPP1R9B PIP4K2C ECT2 CNOT1 MUSK ADD2

1.26e-0411895111GO:0044087
GeneOntologyBiologicalProcessregulation of protein depolymerization

MAP1A SPTBN1 SPECC1L ADD2

1.32e-04105514GO:1901879
GeneOntologyBiologicalProcessactin cytoskeleton organization

KRAS CYFIP1 SPTBN1 HRAS PPP1R9B AIF1L SPECC1L ECT2 ADD2

1.38e-04803519GO:0030036
GeneOntologyBiologicalProcessresponse to protozoan

NRAS HRAS TSPAN32

1.53e-0442513GO:0001562
GeneOntologyBiologicalProcessruffle assembly

CYFIP1 HRAS AIF1L

2.14e-0447513GO:0097178
GeneOntologyBiologicalProcessactin polymerization or depolymerization

CYFIP1 SPTBN1 PPP1R9B SPECC1L ADD2

2.17e-04222515GO:0008154
GeneOntologyBiologicalProcessnegative regulation of translation

CYFIP1 CNOT10 CSNK2A1 MAP3K20 CNOT1

2.55e-04230515GO:0017148
GeneOntologyBiologicalProcessRas protein signal transduction

KRAS NRAS DHCR24 HRAS

2.82e-04128514GO:0007265
GeneOntologyBiologicalProcesscell division

CSNK1A1 SPTBN1 EXOC3 PARD3B MTCL1 SPECC1L STOX1 ECT2

2.88e-04697518GO:0051301
GeneOntologyBiologicalProcessnegative regulation of actin filament depolymerization

SPTBN1 SPECC1L ADD2

2.89e-0452513GO:0030835
GeneOntologyBiologicalProcessprotein localization to membrane

CSNK2A1 SPTBN1 HRAS PPP1R9B MTCL1 OLFM2 MUSK CASK

3.11e-04705518GO:0072657
GeneOntologyBiologicalProcessactin filament-based process

KRAS CYFIP1 SPTBN1 HRAS PPP1R9B AIF1L SPECC1L ECT2 ADD2

3.55e-04912519GO:0030029
GeneOntologyBiologicalProcessregulation of actin cytoskeleton organization

CYFIP1 SPTBN1 HRAS SPECC1L ECT2 ADD2

3.56e-04384516GO:0032956
GeneOntologyBiologicalProcessregulation of organelle organization

CYFIP1 MAP1A SPTBN1 MAP3K20 HRAS SPECC1L STOX1 PIP4K2C ECT2 CNOT1 ADD2

3.61e-0413425111GO:0033043
GeneOntologyBiologicalProcessnegative regulation of cytoplasmic pattern recognition receptor signaling pathway

CSNK1A1 NLRX1 RIOK3

3.99e-0458513GO:0039532
GeneOntologyBiologicalProcessinsulin-like growth factor receptor signaling pathway

KRAS CRIM1 HRAS

4.41e-0460513GO:0048009
GeneOntologyBiologicalProcessRac protein signal transduction

KRAS CYFIP1 MUSK

4.41e-0460513GO:0016601
GeneOntologyBiologicalProcessregulation of protein-containing complex disassembly

MAP1A SPTBN1 SPECC1L ADD2

4.41e-04144514GO:0043244
GeneOntologyBiologicalProcesscell surface receptor protein tyrosine kinase signaling pathway

KRAS LGMN CYFIP1 CRIM1 HRAS PIP4K2C MUSK SVEP1

4.57e-04747518GO:0007169
GeneOntologyBiologicalProcessregulation of actin filament depolymerization

SPTBN1 SPECC1L ADD2

4.63e-0461513GO:0030834
GeneOntologyBiologicalProcessnegative regulation of ubiquitin-dependent protein catabolic process

MAP1A CSNK2A1 RPL5

4.63e-0461513GO:2000059
GeneOntologyBiologicalProcessruffle organization

CYFIP1 HRAS AIF1L

4.63e-0461513GO:0031529
GeneOntologyBiologicalProcessregulation of cytoskeleton organization

CYFIP1 MAP1A SPTBN1 HRAS SPECC1L ECT2 ADD2

5.25e-04579517GO:0051493
GeneOntologyBiologicalProcesscell junction organization

LGMN CYFIP1 PPP1R9B SPECC1L ECT2 MUSK SVEP1 ADD2 CASK

5.72e-04974519GO:0034330
GeneOntologyBiologicalProcessprotein localization to cell periphery

CSNK2A1 SPTBN1 HRAS PPP1R9B OLFM2 CASK

5.85e-04422516GO:1990778
GeneOntologyBiologicalProcesscognition

KRAS LGMN CYFIP1 MAP1A PPP1R9B MUSK

5.93e-04423516GO:0050890
GeneOntologyBiologicalProcesspositive regulation of ruffle assembly

CYFIP1 HRAS

6.17e-0415512GO:1900029
GeneOntologyBiologicalProcessregulation of cellular localization

MAP1A CSNK2A1 SPTBN1 HRAS PPP1R9B MTCL1 ECT2 AKAP8L MUSK CASK

6.64e-0412125110GO:0060341
GeneOntologyBiologicalProcesslocalization within membrane

CSNK2A1 SPTBN1 HRAS PPP1R9B MTCL1 OLFM2 MUSK CASK

7.06e-04798518GO:0051668
GeneOntologyBiologicalProcessregulation of actin filament-based process

CYFIP1 SPTBN1 HRAS SPECC1L ECT2 ADD2

7.11e-04438516GO:0032970
GeneOntologyBiologicalProcessprotein-containing complex disassembly

MAP1A SPTBN1 PPP1R9B SPECC1L ADD2

7.46e-04291515GO:0032984
GeneOntologyBiologicalProcessregulation of synaptic plasticity

KRAS LGMN MAP1A HRAS MUSK

7.70e-04293515GO:0048167
GeneOntologyBiologicalProcessactivation of immune response

NRAS CSNK1A1 NLRX1 HRAS RIOK3 CMKLR1 SVEP1

8.10e-04623517GO:0002253
GeneOntologyBiologicalProcessregulation of protein localization to cell periphery

CSNK2A1 SPTBN1 HRAS PPP1R9B

8.41e-04171514GO:1904375
GeneOntologyBiologicalProcessregulation of cell cycle

LGMN NRAS EP400 CSNK2A1 MAP3K20 HRAS PPP1R9B STOX1 ECT2 CSNK2A3

8.74e-0412565110GO:0051726
GeneOntologyBiologicalProcessnegative regulation of protein-containing complex assembly

CSNK1A1 SPTBN1 RIOK3 ADD2

8.78e-04173514GO:0031333
GeneOntologyBiologicalProcesscellular response to ionizing radiation

MAP3K20 HRAS ECT2

8.82e-0476513GO:0071479
GeneOntologyBiologicalProcesspositive regulation of Rac protein signal transduction

KRAS MUSK

8.94e-0418512GO:0035022
GeneOntologyBiologicalProcesspeptidyl-serine phosphorylation

CSNK1A1 CSNK2A1 MAP3K20 STOX1 CSNK2A3

9.48e-04307515GO:0018105
GeneOntologyBiologicalProcessregulation of actin polymerization or depolymerization

CYFIP1 SPTBN1 SPECC1L ADD2

9.56e-04177514GO:0008064
GeneOntologyBiologicalProcesschromosome segregation

CSNK2A1 MAP3K20 RIOK3 MTCL1 ECT2 AKAP8L

9.70e-04465516GO:0007059
GeneOntologyBiologicalProcessnegative regulation of proteolysis involved in protein catabolic process

MAP1A CSNK2A1 RPL5

9.87e-0479513GO:1903051
GeneOntologyBiologicalProcessregulation of actin filament length

CYFIP1 SPTBN1 SPECC1L ADD2

1.02e-03180514GO:0030832
GeneOntologyBiologicalProcesspeptidyl-serine modification

CSNK1A1 CSNK2A1 MAP3K20 STOX1 CSNK2A3

1.12e-03319515GO:0018209
GeneOntologyBiologicalProcessregulation of ubiquitin-dependent protein catabolic process

MAP1A CSNK1A1 CSNK2A1 RPL5

1.13e-03185514GO:2000058
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

KRAS LGMN CYFIP1 MAP1A HRAS MUSK CASK

1.16e-03663517GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

KRAS LGMN CYFIP1 MAP1A HRAS MUSK CASK

1.17e-03664517GO:0099177
GeneOntologyBiologicalProcessregulation of protein localization

MAP1A CSNK2A1 SPTBN1 HRAS PPP1R9B MTCL1 ECT2 MUSK CASK

1.25e-031087519GO:0032880
GeneOntologyBiologicalProcessregulation of translation

CYFIP1 CNOT10 CSNK2A1 MAP3K20 CNOT1 RPL5

1.32e-03494516GO:0006417
GeneOntologyBiologicalProcessnegative regulation of cytoskeleton organization

MAP1A SPTBN1 SPECC1L ADD2

1.34e-03194514GO:0051494
GeneOntologyBiologicalProcessregulation of small GTPase mediated signal transduction

KRAS CSNK1A1 HRAS ECT2 MUSK

1.36e-03333515GO:0051056
GeneOntologyBiologicalProcessnegative regulation of supramolecular fiber organization

MAP1A SPTBN1 SPECC1L ADD2

1.42e-03197514GO:1902904
GeneOntologyBiologicalProcesspositive regulation of growth

CYFIP1 CSNK2A1 PARP2 CSNK2A3 MUSK

1.47e-03339515GO:0045927
GeneOntologyBiologicalProcessactin filament organization

CYFIP1 SPTBN1 PPP1R9B AIF1L SPECC1L ADD2

1.54e-03509516GO:0007015
GeneOntologyBiologicalProcessmitotic cytokinesis

SPTBN1 EXOC3 ECT2

1.68e-0395513GO:0000281
GeneOntologyBiologicalProcesslearning

KRAS LGMN MAP1A PPP1R9B

1.86e-03212514GO:0007612
GeneOntologyBiologicalProcesspositive regulation of cell growth

CYFIP1 CSNK2A1 PARP2 CSNK2A3

1.89e-03213514GO:0030307
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

KRAS LGMN CYFIP1 MAP1A CADPS HRAS MUSK CASK

1.90e-03931518GO:0098916
GeneOntologyBiologicalProcesschemical synaptic transmission

KRAS LGMN CYFIP1 MAP1A CADPS HRAS MUSK CASK

1.90e-03931518GO:0007268
GeneOntologyBiologicalProcesstrans-synaptic signaling

KRAS LGMN CYFIP1 MAP1A CADPS HRAS MUSK CASK

2.00e-03939518GO:0099537
GeneOntologyCellularComponentprotein kinase CK2 complex

CSNK2A1 CSNK2A3

3.92e-054542GO:0005956
GeneOntologyCellularComponentcell cortex

SPTBN1 EXOC3 PARD3B PPP1R9B STOX1 ECT2

3.78e-04371546GO:0005938
GeneOntologyCellularComponentCCR4-NOT complex

CNOT10 CNOT1

7.68e-0416542GO:0030014
GeneOntologyCellularComponentintracellular protein-containing complex

EP400 ZSWIM5 CSNK1A1 CNOT10 CSNK2A1 ECT2 CSNK2A3 CNOT1 RPL5

7.90e-04972549GO:0140535
GeneOntologyCellularComponentanchoring junction

KRAS CYFIP1 PARD3B PPP1R9B AIF1L SPECC1L ECT2 RPL5 CASK

8.13e-04976549GO:0070161
GeneOntologyCellularComponentpostsynaptic density

MAP1A SPTBN1 PPP1R9B OLFM2 RPL5 ADD2

1.05e-03451546GO:0014069
GeneOntologyCellularComponenthistone deacetylase complex

EP400 SUDS3 CSNK2A1

1.39e-0385543GO:0000118
GeneOntologyCellularComponentasymmetric synapse

MAP1A SPTBN1 PPP1R9B OLFM2 RPL5 ADD2

1.40e-03477546GO:0032279
GeneOntologyCellularComponentSin3-type complex

SUDS3 CSNK2A1

1.46e-0322542GO:0070822
HumanPhenoLinear nevus sebaceous

KRAS NRAS HRAS

1.65e-083143HP:0010817
HumanPhenoNevus sebaceous

KRAS NRAS HRAS

1.65e-075143HP:0010815
HumanPhenoAbnormal palate morphology

KRAS NRAS CSNK2A1 DHCR24 SPTBN1 MAP3K20 HRAS SPECC1L CNOT1 RPL5 MUSK CASK

1.60e-0612021412HP:0000174
HumanPhenoEpidermal nevus

KRAS NRAS HRAS

3.58e-0612143HP:0010816
HumanPhenoAbnormal nasal bridge morphology

KRAS NRAS CSNK2A1 DHCR24 SPTBN1 HRAS SPECC1L CNOT1 RPL5 MUSK CASK

4.34e-0610291411HP:0000422
HumanPhenoHigh palate

KRAS NRAS CSNK2A1 SPTBN1 MAP3K20 HRAS CNOT1 RPL5 MUSK CASK

4.42e-067941410HP:0000218
HumanPhenoDepressed nasal bridge

KRAS NRAS DHCR24 HRAS SPECC1L CNOT1 RPL5 MUSK CASK

5.64e-06612149HP:0005280
HumanPhenoFlattened nasal bridge

KRAS NRAS DHCR24 HRAS SPECC1L CNOT1 RPL5 MUSK CASK

5.64e-06612149HP:0000425
HumanPhenoHemimegalencephaly

KRAS NRAS HRAS

5.91e-0614143HP:0007206
HumanPhenoAbnormal dermatoglyphics

KRAS NRAS CSNK2A1 SPTBN1 HRAS SPECC1L MUSK

7.46e-06314147HP:0007477
HumanPhenoMicrognathia

KRAS NRAS CSNK2A1 DHCR24 MAP3K20 HRAS SPECC1L RPL5 MUSK CASK

7.75e-068431410HP:0000347
HumanPhenoAplasia/Hypoplasia of the mandible

KRAS NRAS CSNK2A1 DHCR24 MAP3K20 HRAS SPECC1L RPL5 MUSK CASK

7.92e-068451410HP:0009118
HumanPhenoShort nose

KRAS NRAS DHCR24 SPTBN1 HRAS SPECC1L CASK

9.38e-06325147HP:0003196
HumanPhenoAbnormalities of placenta or umbilical cord

NRAS SPTBN1 SPECC1L STOX1 MUSK

9.96e-06117145HP:0001194
HumanPhenoSarcoma

KRAS NRAS DHCR24 SPTBN1 HRAS RPL5

1.04e-05210146HP:0100242
HumanPhenoCranial asymmetry

KRAS NRAS HRAS

1.10e-0517143HP:0000267
HumanPhenoBrachydactyly

KRAS NRAS CSNK2A1 MAP3K20 HRAS SPECC1L CNOT1 RPL5 CASK

1.21e-05670149HP:0001156
HumanPhenoRound face

NRAS SPTBN1 HRAS SPECC1L CASK

1.22e-05122145HP:0000311
HumanPhenoShort digit

KRAS NRAS CSNK2A1 MAP3K20 HRAS SPECC1L CNOT1 RPL5 CASK

1.24e-05672149HP:0011927
HumanPhenoFibroma

KRAS NRAS DHCR24 SPTBN1 HRAS

1.32e-05124145HP:0010614
HumanPhenoFibrous tissue neoplasm

KRAS NRAS DHCR24 SPTBN1 HRAS

1.43e-05126145HP:0012316
HumanPhenoAbnormality of prenatal development or birth

KRAS NRAS CSNK2A1 SPTBN1 MAP3K20 HRAS SPECC1L STOX1 CNOT1 RPL5 MUSK

1.48e-0511591411HP:0001197
HumanPhenoAplasia/Hypoplasia involving bones of the skull

KRAS NRAS CSNK2A1 DHCR24 MAP3K20 HRAS SPECC1L RPL5 MUSK CASK

1.66e-059151410HP:0009116
HumanPhenoAbnormal external nose morphology

KRAS NRAS CSNK2A1 DHCR24 SPTBN1 HRAS SPECC1L CNOT1 MUSK CASK

1.68e-059161410HP:0010938
HumanPhenoProminent occiput

KRAS NRAS HRAS CNOT1

1.82e-0562144HP:0000269
HumanPhenoNevus spilus

NRAS HRAS

2.10e-053142HP:0025510
HumanPhenoMelanocytic nevus

KRAS NRAS SPTBN1 HRAS

2.63e-0568144HP:0000995
HumanPhenoAbsent septum pellucidum

KRAS DHCR24 CNOT1 MUSK

2.79e-0569144HP:0001331
HumanPhenoAbnormal upper lip morphology

KRAS NRAS CSNK2A1 SPTBN1 HRAS SPECC1L CNOT1 RPL5 MUSK CASK

3.13e-059801410HP:0000177
HumanPhenoAnteverted nares

KRAS NRAS CSNK2A1 DHCR24 SPTBN1 HRAS SPECC1L CASK

3.30e-05559148HP:0000463
HumanPhenoUpturned nose

KRAS NRAS CSNK2A1 DHCR24 SPTBN1 HRAS SPECC1L CASK

3.30e-05559148HP:0000427
HumanPhenoLow-set ears

KRAS NRAS CSNK2A1 DHCR24 HRAS SPECC1L CNOT1 RPL5 MUSK

3.50e-05761149HP:0000369
HumanPhenoAbnormality of the palmar creases

KRAS CSNK2A1 SPTBN1 HRAS SPECC1L MUSK

3.54e-05260146HP:0010490
HumanPhenoHemihypertrophy

KRAS NRAS HRAS

3.67e-0525143HP:0001528
HumanPhenoAdenoma sebaceum

KRAS NRAS HRAS

3.67e-0525143HP:0009720
HumanPhenoHypophosphatemic rickets

KRAS NRAS HRAS

3.67e-0525143HP:0004912
HumanPhenoAplasia/Hypoplasia involving the nose

KRAS NRAS DHCR24 SPTBN1 HRAS SPECC1L CASK

3.75e-05401147HP:0009924
HumanPhenoAbnormal palmar dermatoglyphics

KRAS CSNK2A1 SPTBN1 HRAS SPECC1L MUSK

3.95e-05265146HP:0001018
HumanPhenoAplasia/hypoplasia affecting bones of the axial skeleton

KRAS NRAS CSNK2A1 DHCR24 MAP3K20 HRAS SPECC1L RPL5 MUSK CASK

4.06e-0510081410HP:0009122
HumanPhenoAbnormal nostril morphology

KRAS NRAS CSNK2A1 DHCR24 SPTBN1 HRAS SPECC1L CASK

4.06e-05575148HP:0005288
HumanPhenoAbnormal pinna morphology

KRAS NRAS CSNK2A1 DHCR24 SPTBN1 HRAS SPECC1L CNOT1 RPL5 MUSK CASK

4.74e-0512991411HP:0000377
HumanPhenoColoboma

KRAS NRAS SPTBN1 HRAS SPECC1L CASK

4.78e-05274146HP:0000589
HumanPhenoSleep abnormality

CSNK2A1 SPTBN1 MAP3K20 HRAS STOX1 CNOT1 MUSK CASK

5.29e-05596148HP:0002360
HumanPhenoAbnormal fourth ventricle morphology

KRAS NRAS HRAS MUSK CASK

5.30e-05165145HP:0010950
HumanPhenoDilated fourth ventricle

KRAS NRAS HRAS MUSK CASK

5.30e-05165145HP:0002198
HumanPhenoSoft tissue sarcoma

KRAS NRAS DHCR24 SPTBN1 HRAS

5.46e-05166145HP:0030448
HumanPhenoLong philtrum

KRAS NRAS HRAS SPECC1L CNOT1 MUSK CASK

5.83e-05429147HP:0000343
HumanPhenoAbnormal male external genitalia morphology

KRAS NRAS CSNK2A1 DHCR24 SPTBN1 HRAS SPECC1L USP9Y RPL5 MUSK CASK

5.97e-0513291411HP:0000032
HumanPhenoAbnormality of the outer ear

KRAS NRAS CSNK2A1 DHCR24 SPTBN1 HRAS SPECC1L CNOT1 RPL5 MUSK CASK

6.35e-0513371411HP:0000356
HumanPhenoAngiofibromas

KRAS NRAS HRAS

6.42e-0530143HP:0010615
HumanPhenoHyperphosphaturia

KRAS NRAS HRAS

6.42e-0530143HP:0003109
HumanPhenoDeep palmar crease

KRAS HRAS SPECC1L

6.42e-0530143HP:0006191
HumanPhenoEpicanthus

KRAS NRAS CSNK2A1 DHCR24 HRAS CNOT1 RPL5 CASK

6.58e-05614148HP:0000286
HumanPhenoTelecanthus

KRAS NRAS DHCR24 HRAS MUSK

6.66e-05173145HP:0000506
HumanPhenoHypoplastic nasal bridge

KRAS DHCR24

6.98e-055142HP:0005281
HumanPhenoCavernous hemangioma

KRAS NRAS HRAS

7.10e-0531143HP:0001048
HumanPhenoTransitional cell carcinoma of the bladder

KRAS NRAS HRAS

7.10e-0531143HP:0006740
HumanPhenoHypertelorism

KRAS NRAS CSNK2A1 SPTBN1 HRAS SPECC1L RPL5 MUSK CASK

7.15e-05830149HP:0000316
HumanPhenoAbnormal hand morphology

KRAS NRAS CSNK2A1 MAP3K20 HRAS SPECC1L CNOT1 RPL5 MUSK CASK

7.75e-0510821410HP:0005922
HumanPhenoPorencephalic cyst

KRAS NRAS HRAS

7.82e-0532143HP:0002132
HumanPhenoAbnormal external genitalia

KRAS NRAS CSNK2A1 DHCR24 SPTBN1 HRAS SPECC1L USP9Y RPL5 MUSK CASK

8.23e-0513721411HP:0000811
HumanPhenoAbnormal morphology of the vestibule of the inner ear

KRAS NRAS HRAS

8.59e-0533143HP:0011376
HumanPhenoBladder carcinoma

KRAS NRAS HRAS

8.59e-0533143HP:0002862
HumanPhenoAbnormal morphology of the nasal alae

KRAS NRAS CSNK2A1 DHCR24 SPTBN1 HRAS SPECC1L CASK

8.81e-05639148HP:0000429
HumanPhenoAbnormal finger morphology

KRAS NRAS CSNK2A1 SPTBN1 MAP3K20 HRAS SPECC1L CNOT1 RPL5 MUSK CASK

9.05e-0513851411HP:0001167
HumanPhenoGenu recurvatum

KRAS NRAS HRAS

9.41e-0534143HP:0002816
HumanPhenoAbnormality of dental color

KRAS NRAS HRAS

9.41e-0534143HP:0011073
HumanPhenoBladder neoplasm

KRAS NRAS HRAS

9.41e-0534143HP:0009725
HumanPhenoAbnormal fetal morphology

KRAS NRAS HRAS SPECC1L RPL5 MUSK

9.58e-05310146HP:0034058
HumanPhenoPolyhydramnios

KRAS NRAS CSNK2A1 MAP3K20 HRAS MUSK

9.94e-05312146HP:0001561
HumanPhenoAbnormal urine phosphate concentration

KRAS NRAS HRAS

1.03e-0435143HP:0012599
HumanPhenoAbnormal mandible morphology

KRAS NRAS CSNK2A1 DHCR24 MAP3K20 HRAS SPECC1L RPL5 MUSK CASK

1.04e-0411181410HP:0000277
HumanPhenoAbnormal lymphocyte apoptosis

KRAS NRAS

1.05e-046142HP:0030886
HumanPhenoNon-medullary thyroid carcinoma

NRAS HRAS

1.05e-046142HP:0040198
HumanPhenoDecreased lymphocyte apoptosis

KRAS NRAS

1.05e-046142HP:0002731
HumanPhenoAbnormal eyelid morphology

KRAS NRAS CSNK2A1 DHCR24 SPTBN1 HRAS SPECC1L CNOT1 RPL5 MUSK CASK

1.07e-0414081411HP:0000492
HumanPhenoAbnormality of globe location

KRAS NRAS CSNK2A1 SPTBN1 HRAS SPECC1L CNOT1 RPL5 MUSK CASK

1.08e-0411221410HP:0100886
HumanPhenoCurly hair

KRAS NRAS HRAS

1.12e-0436143HP:0002212
HumanPhenoAbnormality of the male genitalia

KRAS NRAS CSNK2A1 DHCR24 SPTBN1 HRAS SPECC1L USP9Y RPL5 MUSK CASK

1.31e-0414371411HP:0010461
HumanPhenoSporadic

KRAS NRAS HRAS SPECC1L

1.35e-04103144HP:0003745
HumanPhenoAbnormal placenta morphology

SPTBN1 STOX1 MUSK

1.43e-0439143HP:0100767
HumanPhenoCongenital giant melanocytic nevus

NRAS HRAS

1.46e-047142HP:0005600
HumanPhenoProminence of the premaxilla

NRAS HRAS

1.46e-047142HP:0010759
HumanPhenoBroad forehead

KRAS NRAS SPTBN1 HRAS CASK

1.50e-04205145HP:0000337
HumanPhenoHyperextensibility of the knee

KRAS NRAS HRAS

1.54e-0440143HP:0010500
HumanPhenoPlagiocephaly

KRAS NRAS SPTBN1 HRAS CASK

1.60e-04208145HP:0001357
HumanPhenoAbnormality of the jaws

KRAS NRAS CSNK2A1 DHCR24 MAP3K20 HRAS SPECC1L RPL5 MUSK CASK

1.63e-0411751410HP:0000209
HumanPhenoAbnormal jaw morphology

KRAS NRAS CSNK2A1 DHCR24 MAP3K20 HRAS SPECC1L RPL5 MUSK CASK

1.65e-0411761410HP:0030791
HumanPhenoWide nasal bridge

KRAS NRAS CSNK2A1 SPTBN1 SPECC1L RPL5 CASK

1.73e-04508147HP:0000431
HumanPhenoFetal neck anomaly

KRAS NRAS HRAS MUSK

1.81e-04111144HP:0025667
HumanPhenoAbnormal septum pellucidum morphology

KRAS DHCR24 CNOT1 MUSK

1.87e-04112144HP:0007375
HumanPhenoMegalencephaly

KRAS NRAS HRAS

2.05e-0444143HP:0001355
HumanPhenoAbnormal location of ears

KRAS NRAS CSNK2A1 DHCR24 HRAS SPECC1L CNOT1 RPL5 MUSK

2.05e-04945149HP:0000357
HumanPhenoAbnormality of the philtrum

KRAS NRAS SPTBN1 HRAS SPECC1L CNOT1 MUSK CASK

2.22e-04726148HP:0000288
HumanPhenoAbnormal aortic morphology

KRAS NRAS SPTBN1 HRAS SPECC1L RPL5

2.31e-04363146HP:0030963
HumanPhenoAbnormal shape of the occiput

KRAS NRAS HRAS CNOT1

2.36e-04119144HP:0011217
HumanPhenoAbnormal urine anion concentration

KRAS NRAS HRAS

2.50e-0447143HP:0011866
HumanPhenoRickets

KRAS NRAS HRAS

2.50e-0447143HP:0002748
HumanPhenoAbnormal occipital bone morphology

KRAS NRAS HRAS CNOT1

2.52e-04121144HP:0012294
HumanPhenoRegional abnormality of skin

KRAS NRAS CSNK2A1 SPTBN1 HRAS SPECC1L MUSK

2.58e-04541147HP:0011356
MousePhenohypertension

KRAS HRAS STOX1 ADD2

2.54e-0556434MP:0000231
DomainRAS

KRAS NRAS HRAS

1.40e-0435543PS51421
DomainSmall_GTPase_Ras

KRAS NRAS HRAS

1.66e-0437543IPR020849
DomainProt_kinase_dom

CSNK1A1 CSNK2A1 MAP3K20 RIOK3 CSNK2A3 MUSK CASK

4.94e-04489547IPR000719
DomainPROTEIN_KINASE_DOM

CSNK1A1 CSNK2A1 MAP3K20 RIOK3 CSNK2A3 MUSK CASK

5.18e-04493547PS50011
DomainKinase-like_dom

CSNK1A1 CSNK2A1 MAP3K20 RIOK3 CSNK2A3 MUSK CASK

9.06e-04542547IPR011009
DomainPROTEIN_KINASE_ATP

CSNK1A1 CSNK2A1 MAP3K20 CSNK2A3 MUSK CASK

2.03e-03459546PS00107
DomainSer/Thr_kinase_AS

CSNK1A1 CSNK2A1 MAP3K20 CSNK2A3 CASK

3.64e-03357545IPR008271
DomainS_TKc

CSNK1A1 CSNK2A1 MAP3K20 CSNK2A3 CASK

3.73e-03359545SM00220
DomainPROTEIN_KINASE_ST

CSNK1A1 CSNK2A1 MAP3K20 CSNK2A3 CASK

3.86e-03362545PS00108
DomainRas

KRAS NRAS HRAS

7.14e-03136543PF00071
DomainPDZ

PARD3B PPP1R9B CASK

7.89e-03141543PF00595
DomainPDZ

PARD3B PPP1R9B CASK

9.00e-03148543SM00228
Domain-

PARD3B PPP1R9B CASK

9.34e-031505432.30.42.10
DomainPDZ

PARD3B PPP1R9B CASK

9.51e-03151543PS50106
DomainPDZ

PARD3B PPP1R9B CASK

9.68e-03152543IPR001478
DomainSmall_GTPase

KRAS NRAS HRAS

1.11e-02160543IPR001806
PathwayKEGG_TIGHT_JUNCTION

KRAS NRAS CSNK2A1 MAP3K20 HRAS EXOC3 CASK

7.75e-08132407M11355
PathwayREACTOME_SIGNALING_BY_FLT3_FUSION_PROTEINS

KRAS NRAS SPTBN1 HRAS

2.09e-0719404M41732
PathwayREACTOME_ACTIVATION_OF_RAS_IN_B_CELLS

KRAS NRAS HRAS

2.11e-075403M26921
PathwayREACTOME_ESTROGEN_STIMULATED_SIGNALING_THROUGH_PRKCZ

KRAS NRAS HRAS

4.21e-076403M27951
PathwayKEGG_MEDICUS_VARIANT_LOSS_OF_RASSF1_TO_RAS_RASSF1_SIGNALING_PATHWAY

KRAS NRAS HRAS

4.21e-076403M47433
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_RAS_UBIQUITINATION_BY_CUL3_COMPLEX

KRAS NRAS HRAS

4.21e-076403M47931
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_SPRED_AND_NF1

KRAS NRAS HRAS

4.21e-076403M47932
PathwayREACTOME_RAS_SIGNALING_DOWNSTREAM_OF_NF1_LOSS_OF_FUNCTION_VARIANTS

KRAS NRAS HRAS

7.35e-077403M29717
PathwayREACTOME_SOS_MEDIATED_SIGNALLING

KRAS NRAS HRAS

7.35e-077403M19489
PathwayREACTOME_FLT3_SIGNALING_IN_DISEASE

KRAS NRAS SPTBN1 HRAS

1.08e-0628404M41724
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_RASGAP

KRAS NRAS HRAS

1.17e-068403M47935
PathwayREACTOME_ACTIVATED_NTRK3_SIGNALS_THROUGH_RAS

KRAS NRAS HRAS

1.17e-068403M27919
PathwayKEGG_THYROID_CANCER

KRAS NRAS HRAS CCDC6

1.25e-0629404M523
PathwayREACTOME_EGFR_TRANSACTIVATION_BY_GASTRIN

KRAS NRAS HRAS

1.76e-069403M27156
PathwayREACTOME_SHC_RELATED_EVENTS_TRIGGERED_BY_IGF1R

KRAS NRAS HRAS

1.76e-069403M27173
PathwayREACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_RAS

KRAS NRAS HRAS

1.76e-069403M27904
PathwayREACTOME_MET_ACTIVATES_RAS_SIGNALING

KRAS NRAS HRAS

3.44e-0611403M27740
PathwayREACTOME_SIGNALING_BY_FGFR4_IN_DISEASE

KRAS NRAS HRAS

3.44e-0611403M27535
PathwayKEGG_MEDICUS_VARIANT_RET_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.44e-0611403M47370
PathwayKEGG_MEDICUS_VARIANT_TRK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.44e-0611403M47371
PathwayREACTOME_CONSTITUTIVE_SIGNALING_BY_OVEREXPRESSED_ERBB2

KRAS NRAS HRAS

3.44e-0611403M29814
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RALGDS_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.44e-0611403M47436
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RASSF1_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.44e-0611403M47432
PathwayREACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_FRS2_AND_FRS3

KRAS NRAS HRAS

3.44e-0611403M27911
PathwayWP_BREAST_CANCER_PATHWAY

KRAS NRAS CSNK1A1 CSNK2A1 HRAS CSNK2A3

4.35e-06154406M39739
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

4.57e-0612403M47369
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

4.57e-0612403M47815
PathwayREACTOME_SIGNALING_BY_PDGFRA_TRANSMEMBRANE_JUXTAMEMBRANE_AND_KINASE_DOMAIN_MUTANTS

KRAS NRAS HRAS

4.57e-0612403M29851
PathwayWP_RALA_DOWNSTREAM_REGULATED_GENES

KRAS NRAS HRAS

4.57e-0612403M39408
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY

KRAS NRAS HRAS

5.94e-0613403M47594
PathwayREACTOME_P38MAPK_EVENTS

KRAS NRAS HRAS

5.94e-0613403M1441
PathwayREACTOME_PTK6_REGULATES_RHO_GTPASES_RAS_GTPASE_AND_MAP_KINASES

KRAS NRAS HRAS

7.54e-0614403M27734
PathwayKEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

7.54e-0614403M47364
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

7.54e-0614403M47365
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

7.54e-0614403M47366
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY

KRAS NRAS HRAS

7.54e-0614403M47390
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

7.54e-0614403M47378
PathwayREACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING

KRAS NRAS HRAS

7.54e-0614403M569
PathwayPID_TCR_RAS_PATHWAY

KRAS NRAS HRAS

7.54e-0614403M134
PathwayKEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

7.54e-0614403M47488
PathwayREACTOME_ERYTHROPOIETIN_ACTIVATES_RAS

KRAS NRAS HRAS

7.54e-0614403M27908
PathwayREACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING

KRAS NRAS HRAS

7.54e-0614403M719
PathwayREACTOME_CONSTITUTIVE_SIGNALING_BY_EGFRVIII

KRAS NRAS HRAS

9.41e-0615403M29701
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47367
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47389
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47375
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47380
PathwayKEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47592
PathwayKEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47593
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47640
PathwayKEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47485
PathwayKEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47473
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47474
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47475
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47480
PathwayKEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47495
PathwayKEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47496
PathwayKEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47497
PathwayKEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47472
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47535
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

9.41e-0615403M47531
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.16e-0516403M47363
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.16e-0516403M47373
PathwayKEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.16e-0516403M47381
PathwayKEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.16e-0516403M47804
PathwayKEGG_MEDICUS_ENV_FACTOR_E2_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.16e-0516403M47801
PathwayREACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING

KRAS NRAS HRAS

1.16e-0516403M562
PathwayREACTOME_SIGNALING_BY_ERBB2_ECD_MUTANTS

KRAS NRAS HRAS

1.16e-0516403M29847
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.16e-0516403M47483
PathwayREACTOME_SIGNALING_BY_FLT3_ITD_AND_TKD_MUTANTS

KRAS NRAS HRAS

1.16e-0516403M41733
PathwayKEGG_MEDICUS_REFERENCE_AGE_RAGE_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.16e-0516403M47682
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.40e-0517403M47376
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_AGE_RAGE_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.40e-0517403M47684
PathwayREACTOME_SIGNALING_BY_NTRK3_TRKC

KRAS NRAS HRAS

1.40e-0517403M27918
PathwayREACTOME_SHC_MEDIATED_CASCADE_FGFR3

KRAS NRAS HRAS

1.68e-0518403M27518
PathwayWP_INHIBITION_OF_EXOSOME_BIOGENESIS_AND_SECRETION_BY_MANUMYCIN_A_IN_CRPC_CELLS

KRAS NRAS HRAS

1.68e-0518403M39737
PathwayREACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK

KRAS NRAS HRAS

1.68e-0518403M657
PathwayREACTOME_TIE2_SIGNALING

KRAS NRAS HRAS

1.68e-0518403M11932
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.99e-0519403M47793
PathwayREACTOME_CONSTITUTIVE_SIGNALING_BY_LIGAND_RESPONSIVE_EGFR_CANCER_VARIANTS

KRAS NRAS HRAS

1.99e-0519403M559
PathwayREACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION

KRAS NRAS HRAS

1.99e-0519403M27423
PathwayREACTOME_SIGNALLING_TO_RAS

KRAS NRAS HRAS

2.33e-0520403M12256
PathwayREACTOME_FRS_MEDIATED_FGFR3_SIGNALING

KRAS NRAS HRAS

2.33e-0520403M27519
PathwayREACTOME_SHC_MEDIATED_CASCADE_FGFR4

KRAS NRAS HRAS

2.33e-0520403M27524
PathwayWP_SEROTONIN_RECEPTOR_2_AND_ELKSRFGATA4_SIGNALING

KRAS NRAS HRAS

2.33e-0520403M39485
PathwayREACTOME_SIGNALING_BY_PDGFR_IN_DISEASE

KRAS NRAS HRAS

2.33e-0520403M29849
PathwayREACTOME_RAS_ACTIVATION_UPON_CA2_INFLUX_THROUGH_NMDA_RECEPTOR

KRAS NRAS HRAS

2.33e-0520403M17670
PathwayREACTOME_SIGNALING_BY_KIT_IN_DISEASE

KRAS NRAS HRAS

2.33e-0520403M39002
PathwayREACTOME_SHC_MEDIATED_CASCADE_FGFR1

KRAS NRAS HRAS

2.72e-0521403M27511
PathwayKEGG_MEDICUS_REFERENCE_ACH_CHRN_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

2.72e-0521403M47792
PathwayREACTOME_CD209_DC_SIGN_SIGNALING

KRAS NRAS HRAS

2.72e-0521403M27485
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

KRAS NRAS SPTBN1 HRAS

2.93e-0563404M11187
PathwayREACTOME_FRS_MEDIATED_FGFR4_SIGNALING

KRAS NRAS HRAS

3.14e-0522403M27522
PathwayREACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING

KRAS NRAS HRAS

3.14e-0522403M26929
PathwayREACTOME_FRS_MEDIATED_FGFR1_SIGNALING

KRAS NRAS HRAS

3.60e-0523403M27513
PathwayKEGG_MEDICUS_REFERENCE_E2_ER_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

3.60e-0523403M47799
PathwayREACTOME_RAS_PROCESSING

KRAS NRAS HRAS

4.11e-0524403M38995
PathwayREACTOME_FRS_MEDIATED_FGFR2_SIGNALING

KRAS NRAS HRAS

4.66e-0525403M27517
PathwayWP_RELATIONSHIP_BETWEEN_INFLAMMATION_COX2_AND_EGFR

KRAS NRAS HRAS

4.66e-0525403M39794
PathwayREACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR3

KRAS NRAS HRAS

4.66e-0525403M27520
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

KRAS CYFIP1 CSNK1A1 CSNK2A1 SPTBN1 HRAS PPP1R9B MTCL1 SPECC1L PIP4K2C CCDC6 CNOT1 CASK

2.01e-09963541328671696
Pubmed

Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.

KRAS NRAS HRAS

3.54e-09354325788415
Pubmed

Diagnostic Value of RAS Mutations in Indeterminate Thyroid Nodules.

KRAS NRAS HRAS

3.54e-09354328116986
Pubmed

Analysis of k-ras nuclear expression in fibroblasts and mesangial cells.

KRAS NRAS HRAS

3.54e-09354320090846
Pubmed

RAS gene mutations and histomorphometric measurements in oral squamous cell carcinoma.

KRAS NRAS HRAS

3.54e-09354337013448
Pubmed

Comparison of liver oncogenic potential among human RAS isoforms.

KRAS NRAS HRAS

3.54e-09354326799184
Pubmed

A pericyte origin of spinal cord scar tissue.

KRAS NRAS HRAS

3.54e-09354321737741
Pubmed

Ras isoforms: signaling specificities in CD40 pathway.

KRAS NRAS HRAS

3.54e-09354331906952
Pubmed

Partial functional overlap of the three ras genes in mouse embryonic development.

KRAS NRAS HRAS

3.54e-09354318059342
Pubmed

Evidence of a low prevalence of RAS mutations in a large medullary thyroid cancer series.

KRAS NRAS HRAS

3.54e-09354323240926
Pubmed

Mutations of RAS gene family in specimens of bladder cancer.

KRAS NRAS HRAS

3.54e-09354319101897
Pubmed

Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions.

KRAS NRAS HRAS

3.54e-09354325977330
Pubmed

Promoter hypomethylation as potential confounder of Ras gene overexpression and their clinical significance in subsets of urothelial carcinoma of bladder.

KRAS NRAS HRAS

3.54e-09354333620658
Pubmed

Prevalence of RAS point mutations in papillary thyroid carcinoma; a novel mutation at codon 31 of K-RAS.

KRAS NRAS HRAS

3.54e-09354317943694
Pubmed

Absolute Quantification of Endogenous Ras Isoform Abundance.

KRAS NRAS HRAS

3.54e-09354326560143
Pubmed

Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma.

KRAS NRAS HRAS

3.54e-09354317712732
Pubmed

Comprehensive survey of HRAS, KRAS, and NRAS mutations in proliferative thyroid lesions from an ethnically diverse population.

KRAS NRAS HRAS

3.54e-09354324222113
Pubmed

Deciphering the RAS/ERK pathway in vivo.

KRAS NRAS HRAS

3.54e-09354328202657
Pubmed

Mutational analysis of K-ras and Ras protein expression in larynx squamous cell carcinoma.

KRAS NRAS HRAS

3.54e-09354316761621
Pubmed

Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis.

KRAS NRAS HRAS

3.54e-09354322945650
Pubmed

A comprehensive survey of Ras mutations in cancer.

KRAS NRAS HRAS

3.54e-09354322589270
Pubmed

Activation of RAS family genes in urothelial carcinoma.

KRAS NRAS HRAS

3.54e-09354319303097
Pubmed

A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation.

KRAS NRAS HRAS

3.54e-09354323496764
Pubmed

Distribution of p21ras during primary palate formation of non-cleft and cleft strains of mice.

KRAS NRAS HRAS

3.54e-0935437776260
Pubmed

The spatiotemporal regulation of RAS signalling.

KRAS NRAS HRAS

3.54e-09354327911734
Pubmed

The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.

KRAS NRAS HRAS

3.54e-09354328630043
Pubmed

Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients.

KRAS NRAS HRAS

3.54e-09354320150643
Pubmed

Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis.

KRAS NRAS HRAS

3.54e-09354320971740
Pubmed

Overexpression of wild-type p21Ras plays a prominent role in colorectal cancer.

KRAS NRAS HRAS

3.54e-09354328259994
Pubmed

The variable phenotype and low-risk nature of RAS-positive thyroid nodules.

KRAS NRAS HRAS

3.54e-09354326253102
Pubmed

Frequency of RAS gene mutation and its cooperative genetic events in Southeast Asian adult acute myeloid leukemia.

KRAS NRAS HRAS

3.54e-09354316573741
Pubmed

Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma.

KRAS NRAS HRAS

3.54e-09354327119512
Pubmed

K-ras is an essential gene in the mouse with partial functional overlap with N-ras.

KRAS NRAS HRAS

3.54e-0935439334313
Pubmed

The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions.

KRAS NRAS HRAS

1.41e-08454327936046
Pubmed

Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.

KRAS NRAS HRAS

1.41e-08454310085069
Pubmed

Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice.

KRAS NRAS HRAS

1.41e-08454338849523
Pubmed

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury.

KRAS NRAS HRAS

1.41e-08454329502968
Pubmed

Targeted Long-Read Sequencing Decodes the Transcriptional Atlas of the Founding RAS Gene Family Members.

KRAS NRAS HRAS

1.41e-08454334948093
Pubmed

SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.

KRAS NRAS HRAS

1.41e-0845439674433
Pubmed

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

KRAS NRAS HRAS

1.41e-0845437972015
Pubmed

Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis.

KRAS NRAS HRAS

1.41e-08454310490827
Pubmed

Ras membrane orientation and nanodomain localization generate isoform diversity.

KRAS NRAS HRAS

1.41e-08454320080631
Pubmed

Quantification of spatiotemporal patterns of Ras isoform expression during development.

KRAS NRAS HRAS

1.41e-08454328117393
Pubmed

Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.

KRAS NRAS HRAS

1.41e-08454325999467
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CYFIP1 MAP1A CADPS CSNK1A1 CSNK2A1 SLC27A1 SPTBN1 PPP1R9B SPECC1L PIP4K2C CNOT1 RPL5 ADD2 CASK

2.59e-081431541437142655
Pubmed

The complexity of Raf-1 regulation.

KRAS NRAS HRAS

3.53e-0855439069260
Pubmed

Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin.

KRAS NRAS HRAS

3.53e-08554322982107
Pubmed

Impeded Nedd4-1-mediated Ras degradation underlies Ras-driven tumorigenesis.

KRAS NRAS HRAS

3.53e-08554324746824
Pubmed

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions.

KRAS NRAS HRAS

3.53e-08554334535655
Pubmed

Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation.

KRAS NRAS HRAS

3.53e-08554315558479
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

CYFIP1 NRAS EP400 CSNK1A1 CNOT10 CSNK2A1 DHCR24 PARP2 MAP3K20 AIF1L SPECC1L ECT2 AKAP8L CASK

4.54e-081497541431527615
Pubmed

LZTR1 is a regulator of RAS ubiquitination and signaling.

KRAS CYFIP1 NRAS SPTBN1 HRAS ADD2

4.71e-0812754630442766
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

CSNK2A1 SPTBN1 EXOC3 PDP2 PPP1R9B PTPN21 CCDC6 CNOT1 AKAP8L ADD2 TPD52 CASK

5.68e-081049541227880917
Pubmed

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

KRAS NRAS SPTBN1 HRAS

6.41e-08255448493579
Pubmed

FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy.

KRAS NRAS HRAS

7.05e-08654321072204
Pubmed

Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf.

KRAS NRAS HRAS

7.05e-0865439753431
Pubmed

Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1.

KRAS NRAS HRAS

7.05e-08654310882715
Pubmed

Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth.

KRAS NRAS HRAS

7.05e-08654329615452
Pubmed

LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases.

KRAS NRAS HRAS

7.05e-08654331337872
Pubmed

Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1.

KRAS NRAS HRAS

1.23e-07754319487299
Pubmed

Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation.

KRAS NRAS HRAS

1.23e-07754335904492
Pubmed

Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.

KRAS NRAS HRAS

1.23e-07754320526288
Pubmed

H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice.

KRAS NRAS HRAS

1.23e-07754320179099
Pubmed

SmgGDS displays differential binding and exchange activity towards different Ras isoforms.

KRAS NRAS HRAS

1.23e-07754311948427
Pubmed

Molecular, morphologic, and outcome analysis of thyroid carcinomas according to degree of extrathyroid extension.

KRAS NRAS HRAS

1.23e-07754320860430
Pubmed

Absence of BRAF, NRAS, KRAS, HRAS mutations, and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto thyroiditis from papillary thyroid carcinomas.

KRAS NRAS HRAS

1.23e-07754320012784
Pubmed

Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma.

KRAS NRAS HRAS

1.23e-07754322199277
Pubmed

The structural basis of the activation of Ras by Sos.

KRAS NRAS HRAS

1.23e-0775439690470
Pubmed

Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.

KRAS NRAS HRAS

1.97e-07854315064703
Pubmed

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.

KRAS NRAS HRAS

1.97e-07854320150892
Pubmed

The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.

KRAS NRAS HRAS

2.95e-07954310783161
Pubmed

Signals transduced through the CD4 molecule interfere with TCR/CD3-mediated ras activation leading to T cell anergy/apoptosis.

KRAS NRAS HRAS

2.95e-0795439344703
Pubmed

Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development.

KRAS NRAS HRAS

4.21e-071054334215617
Pubmed

Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43.

KRAS NRAS HRAS

4.21e-071054329959233
Pubmed

SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.

KRAS NRAS HRAS

5.79e-071154328263956
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

MAP1A EP400 CSNK2A1 SPTBN1 USP9Y CNOT1 SNRPF RPL5 AKAP8L ADD2 CASK

7.06e-071082541138697112
Pubmed

CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells.

KRAS NRAS HRAS

7.71e-07125439269777
Pubmed

Ras effectors and their role in mitogenesis and oncogenesis.

KRAS NRAS HRAS

7.71e-07125439297626
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

CYFIP1 CSNK2A1 SPTBN1 EXOC3 USP9Y CSNK2A3 CNOT1 AKAP8L

9.61e-0749754836774506
Pubmed

K-RasV14I recapitulates Noonan syndrome in mice.

KRAS NRAS HRAS

1.27e-061454325359213
Pubmed

The Ras branch of small GTPases: Ras family members don't fall far from the tree.

KRAS NRAS HRAS

1.59e-061554310712923
Pubmed

Ras signaling is essential for skin development.

KRAS NRAS HRAS

1.59e-061554323831572
Pubmed

Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomes.

KRAS NRAS HRAS

1.95e-06165438095010
Pubmed

Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080.

NRAS HRAS

2.37e-0625426086315
Pubmed

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.

KRAS HRAS

2.37e-06254210871846
Pubmed

RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.

KRAS NRAS

2.37e-06254219789336
Pubmed

Association of KRAS and NRAS gene polymorphisms with Wilms tumor risk: a four-center case-control study.

KRAS NRAS

2.37e-06254230860980
Pubmed

Involvement of H- and N-Ras isoforms in transforming growth factor-beta1-induced proliferation and in collagen and fibronectin synthesis.

NRAS HRAS

2.37e-06254216624289
Pubmed

Deciphering KRAS and NRAS mutated clone dynamics in MLL-AF4 paediatric leukaemia by ultra deep sequencing analysis.

KRAS NRAS

2.37e-06254227698462
Pubmed

Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer.

KRAS NRAS

2.37e-06254234117033
Pubmed

RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse: a study of the Japanese Childhood AML Cooperative Study Group.

KRAS NRAS

2.37e-06254222407852
Pubmed

Frequent KRAS and HRAS mutations in squamous cell papillomas of the head and neck.

KRAS HRAS

2.37e-06254231960612
Pubmed

RAS mutation status predicts survival and patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases.

KRAS NRAS

2.37e-06254224018645
Pubmed

A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer.

KRAS HRAS

2.37e-0625426098458
Pubmed

Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay.

NRAS HRAS

2.37e-0625421970154
Pubmed

Mutations of the p53 tumor suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand.

NRAS HRAS

2.37e-0625428280380
Pubmed

Combined HRAS and NRAS ablation induces a RASopathy phenotype in mice.

NRAS HRAS

2.37e-06254238886790
Pubmed

A homologous promoterless K-ras cDNA targeting endogenous K-ras expression inhibits human pancreatic cancer cell growth in vitro and in vivo.

KRAS HRAS

2.37e-06254218769120
Pubmed

Wild-type NRas and KRas perform distinct functions during transformation.

KRAS NRAS

2.37e-06254217636015
Pubmed

Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells.

KRAS HRAS

2.37e-06254220188103
InteractionLYN interactions

KRAS CYFIP1 NRAS CNOT10 CSNK2A1 SPTBN1 HRAS EXOC3 ZCCHC7 CSNK2A3 RPL5 ADD2 CASK

3.98e-087205413int:LYN
InteractionNAV2 interactions

KRAS NRAS SPTBN1 HRAS PPP1R9B

1.02e-0743545int:NAV2
InteractionSEPTIN8 interactions

KRAS NRAS SPTBN1 HRAS RIOK3 PPP1R9B

1.19e-0787546int:SEPTIN8
InteractionADD1 interactions

KRAS NRAS CADPS SPTBN1 HRAS PPP1R9B ADD2

3.54e-07171547int:ADD1
InteractionHEPH interactions

KRAS NRAS HRAS

3.62e-076543int:HEPH
InteractionFLOT1 interactions

KRAS NRAS EP400 SPTBN1 HRAS EXOC3 ELF2 ECT2 ADD2 CASK

4.55e-074755410int:FLOT1
InteractionF11R interactions

KRAS NRAS CSNK2A1 HRAS CASK

5.58e-0760545int:F11R
InteractionPLCB1 interactions

KRAS NRAS SPTBN1 HRAS PPP1R9B

7.14e-0763545int:PLCB1
InteractionACTG1 interactions

KRAS CYFIP1 MAP1A EP400 CSNK1A1 SPTBN1 HRAS PPP1R9B SPECC1L PIP4K2C

1.04e-065205410int:ACTG1
InteractionSLC1A4 interactions

KRAS NRAS HRAS PPP1R9B

1.20e-0630544int:SLC1A4
InteractionCYFIP1 interactions

KRAS CYFIP1 NRAS CSNK1A1 SPTBN1 HRAS PPP1R9B CCDC6

1.36e-06303548int:CYFIP1
InteractionF2RL3 interactions

KRAS CSNK2A1 CSNK2A3

1.51e-069543int:F2RL3
InteractionATG16L1 interactions

KRAS CYFIP1 MAP1A CSNK1A1 CNOT10 CSNK2A1 EXOC3 PPP1R9B MTCL1 SPECC1L CCDC6 SNRPF RPL5 ADD2

1.52e-0611615414int:ATG16L1
InteractionSPTBN1 interactions

KRAS CYFIP1 NRAS CSNK2A1 SPTBN1 HRAS PPP1R9B MINDY2 ECT2

1.61e-06421549int:SPTBN1
InteractionYWHAB interactions

KRAS CYFIP1 CSNK2A1 SPTBN1 MAP3K20 PARD3B PPP1R9B MTCL1 ZCCHC7 PTPN21 PIP4K2C CCDC6 ECT2

1.98e-0610145413int:YWHAB
InteractionTRPV2 interactions

KRAS NRAS HRAS

2.15e-0610543int:TRPV2
InteractionSLC2A3 interactions

KRAS NRAS HRAS PPP1R9B

2.27e-0635544int:SLC2A3
InteractionCAPZB interactions

KRAS CNOT10 CSNK2A1 SPTBN1 PPP1R9B AIF1L MTCL1 SPECC1L ECT2 CNOT1 SNRPF RPL5 AKAP8L

2.89e-0610495413int:CAPZB
InteractionPLEKHO1 interactions

KRAS NRAS CSNK2A1 HRAS RPL5

3.00e-0684545int:PLEKHO1
InteractionKIF2A interactions

CYFIP1 MAP1A SPTBN1 EXOC3 PPP1R9B PIP4K2C CASK

3.62e-06242547int:KIF2A
InteractionTPD52L2 interactions

KRAS CYFIP1 NRAS HRAS CNOT1 TPD52

3.71e-06156546int:TPD52L2
InteractionGTSF1 interactions

KRAS NRAS HRAS

3.93e-0612543int:GTSF1
InteractionABR interactions

CSNK2A1 HRAS ECT2 CSNK2A3

4.33e-0641544int:ABR
InteractionMAX interactions

KRAS EP400 SUDS3 CSNK2A1 PIP4K2C CCDC6 CNOT1

4.60e-06251547int:MAX
InteractionYWHAH interactions

KRAS LGMN CYFIP1 CSNK1A1 SPTBN1 MAP3K20 PARD3B PPP1R9B MTCL1 SPECC1L PTPN21 CCDC6 ECT2

4.95e-0611025413int:YWHAH
InteractionADD2 interactions

KRAS NRAS HRAS PPP1R9B ADD2

4.97e-0693545int:ADD2
InteractionIPMK interactions

KRAS CSNK2A1 CSNK2A3

5.10e-0613543int:IPMK
InteractionHAGHL interactions

CSNK2A1 PIP4K2C CSNK2A3

5.10e-0613543int:HAGHL
InteractionPPFIBP2 interactions

KRAS NRAS HRAS SPECC1L

5.26e-0643544int:PPFIBP2
InteractionFBXO42 interactions

KRAS CYFIP1 MAP1A EP400 RIOK3 PIP4K2C CCDC6

5.65e-06259547int:FBXO42
InteractionTNKS1BP1 interactions

KRAS CNOT10 CSNK2A1 SPTBN1 CCDC6 CNOT1

5.69e-06168546int:TNKS1BP1
InteractionPIP4K2B interactions

CSNK1A1 CSNK2A1 PIP4K2C CSNK2A3 CASK

5.81e-0696545int:PIP4K2B
InteractionCADM1 interactions

KRAS HRAS PIP4K2C CASK

6.32e-0645544int:CADM1
InteractionITGB6 interactions

KRAS NRAS HRAS

6.48e-0614543int:ITGB6
InteractionSPTBN2 interactions

KRAS CYFIP1 NRAS SPTBN1 PPP1R9B ECT2

6.51e-06172546int:SPTBN2
InteractionOCLN interactions

KRAS NRAS CSNK1A1 CSNK2A1 SPTBN1 HRAS EXOC3 ADD2 CASK

6.53e-06500549int:OCLN
InteractionKIF1B interactions

CSNK1A1 CSNK2A1 SPTBN1 PIP4K2C CCDC6 CASK

6.73e-06173546int:KIF1B
InteractionCDC42 interactions

KRAS CYFIP1 CRIM1 ZSWIM5 SPTBN1 MAP3K20 HRAS EXOC3 RIOK3 PPP1R9B ECT2 CNOT1 SNRPF CASK

6.97e-0613235414int:CDC42
InteractionWDR76 interactions

KRAS NRAS EP400 PARP2 SPTBN1 HRAS EXOC3 CNOT1

7.67e-06383548int:WDR76
InteractionEPB41L3 interactions

KRAS CYFIP1 NRAS CSNK2A1 SPTBN1 PPP1R9B PIP4K2C

7.78e-06272547int:EPB41L3
InteractionRPS21 interactions

KRAS CSNK2A1 RIOK3 PIP4K2C CCDC6 ECT2 RPL5

8.76e-06277547int:RPS21
InteractionROCK2 interactions

KRAS CYFIP1 NRAS HRAS PPP1R9B ADD2

9.00e-06182546int:ROCK2
InteractionWDR44 interactions

KRAS NRAS CSNK2A1 HRAS PIP4K2C

9.01e-06105545int:WDR44
InteractionELMOD3 interactions

KRAS NRAS HRAS

9.94e-0616543int:ELMOD3
InteractionSAMSN1 interactions

KRAS NRAS HRAS

9.94e-0616543int:SAMSN1
InteractionPCDH18 interactions

NRAS CSNK2A1 CSNK2A3

9.94e-0616543int:PCDH18
InteractionEPB41L1 interactions

KRAS CYFIP1 NRAS HRAS PPP1R9B PIP4K2C

1.05e-05187546int:EPB41L1
InteractionFMR1 interactions

KRAS CYFIP1 CSNK2A1 SPTBN1 MTCL1 ECT2 CNOT1 RPL5 CASK

1.14e-05536549int:FMR1
InteractionHSP90AB2P interactions

KRAS NRAS CSNK2A1 HRAS ECT2

1.18e-05111545int:HSP90AB2P
InteractionMINK1 interactions

KRAS NRAS CNOT10 CSNK2A1 HRAS CNOT1

1.26e-05193546int:MINK1
InteractionKCTD13 interactions

CYFIP1 MAP1A CADPS CSNK1A1 CSNK2A1 SLC27A1 SPTBN1 PPP1R9B SPECC1L PIP4K2C CNOT1 RPL5 ADD2 CASK

1.27e-0513945414int:KCTD13
InteractionATP2B4 interactions

KRAS NRAS HRAS PPP1R9B CMKLR1 CASK

1.37e-05196546int:ATP2B4
InteractionEPB41L5 interactions

KRAS NRAS HRAS SPECC1L PIP4K2C ECT2 CASK

1.41e-05298547int:EPB41L5
InteractionKIF23 interactions

KRAS CSNK1A1 CSNK2A1 SPTBN1 PPP1R9B MTCL1 USP9Y ECT2 CSNK2A3 RPL5 AKAP8L ADD2

1.41e-0510315412int:KIF23
InteractionEPB41L2 interactions

KRAS NRAS CSNK2A1 HRAS PIP4K2C RPL5 CASK

1.44e-05299547int:EPB41L2
InteractionMPP1 interactions

KRAS NRAS MAP3K20 HRAS CCDC6

1.59e-05118545int:MPP1
InteractionEHBP1L1 interactions

KRAS NRAS HRAS SPECC1L

1.64e-0557544int:EHBP1L1
InteractionGYPC interactions

KRAS NRAS HRAS

1.71e-0519543int:GYPC
InteractionCSNK1A1L interactions

CSNK1A1 PPP1R9B PIP4K2C ECT2

1.75e-0558544int:CSNK1A1L
InteractionTIAM1 interactions

KRAS NRAS CSNK1A1 HRAS PPP1R9B CASK

1.77e-05205546int:TIAM1
InteractionCAPZA2 interactions

CYFIP1 CNOT10 SPTBN1 PPP1R9B MTCL1 SPECC1L ECT2 CNOT1

1.77e-05430548int:CAPZA2
InteractionSEPTIN11 interactions

KRAS NRAS CSNK1A1 HRAS PPP1R9B

1.87e-05122545int:SEPTIN11
InteractionSLC6A9 interactions

KRAS NRAS HRAS

2.01e-0520543int:SLC6A9
InteractionSUSD5 interactions

KRAS NRAS HRAS

2.01e-0520543int:SUSD5
InteractionPLCE1 interactions

NRAS CSNK1A1 HRAS

2.01e-0520543int:PLCE1
InteractionPPP1CC interactions

KRAS CYFIP1 CSNK1A1 SPTBN1 PPP1R9B SPECC1L CCDC6 ECT2 RPL5 CASK

2.27e-057385410int:PPP1CC
InteractionSEPTIN5 interactions

KRAS NRAS HRAS PPP1R9B

2.29e-0562544int:SEPTIN5
InteractionTAOK3 interactions

KRAS LGMN NRAS HRAS

2.60e-0564544int:TAOK3
InteractionDLG3 interactions

KRAS HRAS EXOC3 PPP1R9B CASK

2.63e-05131545int:DLG3
InteractionNECTIN1 interactions

KRAS NRAS HRAS

2.70e-0522543int:NECTIN1
InteractionSYT7 interactions

KRAS HRAS PPP1R9B

3.10e-0523543int:SYT7
InteractionSLC23A2 interactions

KRAS NRAS HRAS

3.10e-0523543int:SLC23A2
InteractionBAP1 interactions

KRAS CYFIP1 CSNK2A1 SPTBN1 ELF2 AIF1L CCDC6 CNOT1 SNRPF RPL5 AKAP8L ADD2 TPD52

3.25e-0513145413int:BAP1
InteractionYWHAZ interactions

KRAS CYFIP1 CSNK1A1 SPTBN1 MAP3K20 PARD3B PPP1R9B ZCCHC7 PTPN21 CCDC6 ECT2 SNRPF RPL5

3.38e-0513195413int:YWHAZ
InteractionTULP3 interactions

KRAS NRAS HRAS EXOC3 RIOK3 PIP4K2C AKAP8L

3.66e-05346547int:TULP3
InteractionEXOC1 interactions

KRAS NRAS HRAS EXOC3 CCDC6

4.01e-05143545int:EXOC1
InteractionPIP4P1 interactions

KRAS NRAS HRAS TPD52

4.14e-0572544int:PIP4P1
InteractionFRMD7 interactions

NRAS CASK

4.21e-054542int:FRMD7
InteractionGAL3ST4 interactions

NRAS ECT2

4.21e-054542int:GAL3ST4
InteractionEPB41 interactions

KRAS NRAS SPTBN1 HRAS CASK

4.28e-05145545int:EPB41
InteractionDLG1 interactions

KRAS NRAS MAP1A HRAS PPP1R9B CASK

4.29e-05240546int:DLG1
InteractionEXOC3 interactions

KRAS NRAS HRAS EXOC3 CMKLR1

5.04e-05150545int:EXOC3
InteractionPDLIM4 interactions

KRAS NRAS HRAS

5.08e-0527543int:PDLIM4
InteractionRGL2 interactions

KRAS NRAS HRAS

5.68e-0528543int:RGL2
InteractionCTNNB1 interactions

KRAS CYFIP1 NRAS EP400 CSNK1A1 CSNK2A1 HRAS PARD3B PPP1R9B SPECC1L ECT2

6.19e-0510095411int:CTNNB1
InteractionRPS20 interactions

KRAS NRAS CSNK2A1 MAP3K20 RIOK3 ECT2 CNOT1 RPL5

6.20e-05513548int:RPS20
InteractionDCUN1D3 interactions

KRAS NRAS HRAS

6.32e-0529543int:DCUN1D3
InteractionSLC35A2 interactions

KRAS NRAS HRAS

6.32e-0529543int:SLC35A2
InteractionRHOB interactions

CYFIP1 CRIM1 MAP1A CSNK1A1 SPTBN1 EXOC3 PARD3B PIP4K2C ECT2 CASK

6.78e-058405410int:RHOB
InteractionSLITRK2 interactions

KRAS NRAS

7.01e-055542int:SLITRK2
InteractionZNF428 interactions

CSNK2A1 PARP2 PIP4K2C

7.01e-0530543int:ZNF428
InteractionCD276 interactions

KRAS NRAS HRAS

7.01e-0530543int:CD276
InteractionDLG2 interactions

KRAS CYFIP1 MAP1A PPP1R9B

7.23e-0583544int:DLG2
InteractionERBIN interactions

KRAS NRAS HRAS ECT2 MUSK CASK

7.43e-05265546int:ERBIN
InteractionDLGAP4 interactions

KRAS NRAS PPP1R9B CASK

7.58e-0584544int:DLGAP4
InteractionSCRIB interactions

KRAS NRAS HRAS PIP4K2C ECT2 MUSK

7.59e-05266546int:SCRIB
InteractionAPC interactions

CSNK1A1 CSNK2A1 SPTBN1 HRAS SPECC1L CCDC6 CASK

7.67e-05389547int:APC
InteractionMINDY2 interactions

CADPS SPTBN1 MINDY2

7.75e-0531543int:MINDY2
InteractionDCBLD1 interactions

KRAS NRAS HRAS

7.75e-0531543int:DCBLD1
InteractionJAM3 interactions

KRAS NRAS HRAS

7.75e-0531543int:JAM3
GeneFamilyRAS type GTPase family

KRAS NRAS HRAS

2.40e-0531333389
GeneFamilyCCR4-NOT transcription complex

CNOT10 CNOT1

1.76e-04113321023
GeneFamilyAtaxins|Trinucleotide repeat containing

EP400 CASK

9.44e-0425332775
GeneFamilyPDZ domain containing

PARD3B PPP1R9B CASK

2.64e-031523331220
CoexpressionTABULA_MURIS_SENIS_MESENTERIC_ADIPOSE_TISSUE_MESENCHYMAL_STEM_CELL_OF_ADIPOSE_AGEING

LGMN NRAS MAP1A EP400 CSNK2A1 MAP3K20 HRAS CCDC6 RPL5

1.00e-05685549MM3782
ToppCellIIF-Lymphocyte-T_NK-dnT|IIF / Disease, Lineage and Cell Type

SPTBN1 PDP2 OLFM2 SVEP1

2.97e-05146544d0f361662db5f7be26104346e8431f7e30c5ce3a
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VPREB1 CADPS OLFM2 ADD2

5.01e-0516754455c3c68af269fcf40f2b080ae4489523609ad388
ToppCellsevere-Myeloid-mDC|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

LGMN CCDC6 SNRPF RPL5

5.13e-05168544eff37a92d41624924201372cc09f9eb07b60aec1
ToppCellCOVID_vent-Lymphocytic-Dendritic-pDC|COVID_vent / Disease condition, Lineage, Cell class and subclass

LGMN MAP1A MTCL1 STOX1

5.49e-05171544779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCellCOVID_vent-Lymphocytic-Dendritic|COVID_vent / Disease condition, Lineage, Cell class and subclass

LGMN MAP1A MTCL1 STOX1

5.49e-05171544debbb071d260639b16269c94d172766908325c58
ToppCell10x5'v1-week_12-13-Myeloid_macrophage-stroma-monocytoid_macrophage|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

LGMN CYFIP1 CMKLR1 CASK

5.62e-051725449befd44bce43eb5dc1fe3d2e44608f442cf74a47
ToppCellMild/Remission-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

VPREB1 CRIM1 ELF2 ZCCHC7

5.75e-05173544694d02c4d2dc2de4b344544f9124fec40fcf7d8f
ToppCellControl-Lymphoid-pDC|Control / Condition, Lineage and Cell class

LGMN MAP1A CMKLR1 STOX1

6.14e-051765445de16ff65476bde8b23322a44e11412e14f1bafe
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KRAS CMKLR1 MINDY2 SVEP1

6.28e-05177544164ffbbf798defa3728197deb1a14b661490e525
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LGMN CRIM1 MAP1A CMKLR1

6.56e-05179544124da6f882968dc0d05f3edd8f3b4d61617cc214
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LGMN CRIM1 MAP1A CMKLR1

6.56e-05179544edc5ef693dc4e7ea70717b77fb908fc784dce3a2
ToppCell10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T|lymph-node_spleen / Manually curated celltypes from each tissue

NLRX1 DHCR24 MAP3K20 STOX1

7.61e-0518654417eec1efad1f5e9ced1eb6bc9eb5dd7ded789c61
ToppCell10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-ELP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

VPREB1 MAP1A ZCCHC7 RPL5

8.10e-0518954446c3f3dff71e7131a5ad1cd3b68709051a474c3c
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|PND01-03-samps / Age Group, Lineage, Cell class and subclass

MAP3K20 CMKLR1 SPECC1L SVEP1

8.43e-05191544e7c605b56934d1383237c1f946dbccef25d91368
ToppCellfacs-Thymus-Flowthrough-3m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRAS CSNK1A1 CSNK2A1 TSPAN32

8.60e-051925447a0ef1702d6538e5611cfdc633d8558f9523845c
ToppCellfacs-Thymus-Flowthrough-3m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRAS CSNK1A1 CSNK2A1 TSPAN32

8.60e-0519254405043fb75319b64f5ed7aee6a232309dcae891b8
ToppCellPND01-03-samps-Mesenchymal|PND01-03-samps / Age Group, Lineage, Cell class and subclass

MAP3K20 CMKLR1 SPECC1L SVEP1

8.95e-051945444f9bd0ded0dde1df885850714f29e73e992539a5
ToppCellMild/Remission-B_naive-8|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

VPREB1 CRIM1 ELF2 ZCCHC7

9.13e-051955440a3221e4d1fa31a35868bdda0f0cc873c233b407
ToppCelldroplet-Tongue-TONGUE|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSNK2A1 DHCR24 CAPNS2 MINDY2

9.32e-0519654444a30b1a5f3d8c845e5f3bd17d8102a7449f555b
ToppCelldroplet-Tongue-TONGUE-1m|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSNK2A1 DHCR24 CAPNS2 MINDY2

9.32e-051965449935bdb10789e8cfc922dca526ca3bf8317fe270
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSNK2A1 DHCR24 CAPNS2 MINDY2

9.32e-05196544a85f5f1e6acc798e9e02b1a21e0ffe87a323c333
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast|PND01-03-samps / Age Group, Lineage, Cell class and subclass

MAP3K20 CMKLR1 SPECC1L SVEP1

9.32e-0519654454f4cf778f95a9ff662e5c7520916a25e605bf95
ToppCell10x5'v1-week_14-16-Lymphocytic_B|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

VPREB1 SPTBN1 ZCCHC7 TPD52

9.50e-0519754431dfd9842410b5c629f39b5130233995dceb0aef
ToppCell10x5'v1-week_14-16-Lymphocytic_B-B_lineage-pre_B_progenitor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

VPREB1 SPTBN1 ZCCHC7 TPD52

9.50e-0519754478122e1fb80e0ac3084dd4f7c551996330a701df
ToppCell10x5'v1-week_14-16-Lymphocytic_B-B_lineage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

VPREB1 SPTBN1 ZCCHC7 TPD52

9.50e-051975447290f05d0b8465637420119941bcbf2fae44a7e4
ToppCell10x3'2.3-week_17-19-Lymphocytic_B|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

VPREB1 SPTBN1 ZCCHC7 TPD52

9.69e-051985445f465cf5c7493e32d9afe9e9d05757d0a95acc33
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

SPECC1L STOX1 MUSK SVEP1

9.69e-051985440c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

VPREB1 SPTBN1 ZCCHC7 TPD52

9.69e-0519854477ce3fe1ab161c0faf8987e73a64ab61294b9255
ToppCellCOVID-19_Severe-cDC|World / disease group, cell group and cell class

CYFIP1 MAP3K20 AIF1L CCDC6

9.69e-05198544c452334249f047265ae89dcabe7de446d968cae6
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

LGMN CYFIP1 SNRPF RPL5

9.88e-051995448e87ba32fcc1d45be73098e5baa6c9c6369b97df
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

LGMN CYFIP1 SNRPF RPL5

9.88e-0519954415d7b2479a1426dd8f38ef70225ce07f48f320b2
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

LGMN CYFIP1 SNRPF RPL5

1.01e-042005445a3b04aaad9562636aa34750d6025e0fe0f9b2ba
ToppCellSepsis-Bac-SEP-Lymphocyte-B-B_naive|Bac-SEP / Disease, condition lineage and cell class

ZCCHC7 RPL5 ADD2 TPD52

1.01e-04200544d377227314a4684d1bad15a13d87b1fa74b998f1
ToppCellMS-IIF-Lymphocyte-T/NK-dn_T|IIF / Disease, condition lineage and cell class

SPTBN1 PDP2 OLFM2 COQ10B

1.01e-04200544c34fff02992cba6bcc2308019cb00b94e1227300
DrugL 744832

KRAS NRAS HRAS

5.04e-084543ctd:C096898
DrugAC1L32OA

KRAS NRAS HRAS

1.05e-069543CID000107745
Drugisoprene

KRAS HRAS

5.52e-062542ctd:C005059
DrugProstaglandin E1; Up 200; 10uM; MCF7; HT_HG-U133A

NLRX1 MAP3K20 RIOK3 MTCL1 TPD52 CASK

7.11e-061975466576_UP
DrugTetranitromethane

KRAS HRAS

1.65e-053542ctd:D013774
DrugGGTI 2147

KRAS NRAS

1.65e-053542ctd:C466792
DrugS-ethylcysteine

KRAS CSNK1A1 CSNK2A1

3.96e-0528543CID000030993
DiseaseNevus sebaceous

KRAS NRAS HRAS

5.16e-093523C3854181
DiseaseInflammatory linear verrucous epidermal nevus

KRAS NRAS HRAS

5.16e-093523C0473574
DiseaseSCHIMMELPENNING-FEUERSTEIN-MIMS SYNDROME

KRAS NRAS HRAS

5.16e-093523163200
DiseaseVerrucous epidermal nevus

KRAS NRAS HRAS

5.16e-093523C0362030
Diseaselinear nevus sebaceous syndrome (is_implicated_in)

KRAS NRAS HRAS

5.16e-093523DOID:0111530 (is_implicated_in)
DiseaseNoonan syndrome 3 (implicated_via_orthology)

KRAS NRAS HRAS

5.16e-093523DOID:0060581 (implicated_via_orthology)
DiseaseNevus Sebaceus of Jadassohn

KRAS NRAS HRAS

5.16e-093523C4552097
DiseaseOrganoid Nevus Phakomatosis

KRAS NRAS HRAS

5.16e-093523C0265329
DiseaseLinear nevus sebaceous syndrome

KRAS NRAS HRAS

5.16e-093523cv:C4552097
DiseaseLinear Verrucous Epidermal Nevus

KRAS NRAS HRAS

5.16e-093523C3179502
Diseasecervical cancer (implicated_via_orthology)

KRAS NRAS HRAS

5.16e-093523DOID:4362 (implicated_via_orthology)
DiseaseNEVUS, EPIDERMAL (disorder)

KRAS NRAS HRAS

5.15e-085523C0334082
DiseaseFollicular thyroid carcinoma

KRAS NRAS HRAS

5.15e-085523C0206682
DiseaseHemimegalencephaly

KRAS NRAS HRAS

1.03e-076523C0431391
DiseaseRASopathy (implicated_via_orthology)

KRAS NRAS HRAS

4.30e-079523DOID:0080690 (implicated_via_orthology)
Diseaseheart disease (implicated_via_orthology)

KRAS NRAS HRAS CNOT1

6.05e-0738524DOID:114 (implicated_via_orthology)
DiseaseTurner Syndrome, Male

KRAS NRAS HRAS

8.43e-0711523C0041409
DiseaseFemale Pseudo-Turner Syndrome

KRAS NRAS HRAS

8.43e-0711523C1527404
DiseaseNoonan Syndrome 1

KRAS NRAS HRAS

8.43e-0711523C4551602
Diseasekidney cancer (implicated_via_orthology)

KRAS NRAS HRAS

8.43e-0711523DOID:263 (implicated_via_orthology)
Diseasewhole-brain volume, Alzheimer's disease biomarker measurement

KRAS NRAS ADD2

1.85e-0614523EFO_0005089, EFO_0006514
DiseaseRASopathy

KRAS NRAS HRAS

2.31e-0615523cv:C5555857
DiseaseMelanocytic nevus

NRAS HRAS

3.05e-062522cv:C0027962
DiseaseRAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER

KRAS NRAS

3.05e-062522C2674723
DiseaseRAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER

KRAS NRAS

3.05e-062522614470
DiseaseAutoimmune lymphoproliferative syndrome type 4

KRAS NRAS

3.05e-062522cv:C2674723
Diseaseautoimmune lymphoproliferative syndrome type 4 (is_implicated_in)

KRAS NRAS

3.05e-062522DOID:0110117 (is_implicated_in)
Diseaselarge congenital melanocytic nevus (is_implicated_in)

NRAS HRAS

3.05e-062522DOID:0111359 (is_implicated_in)
DiseaseMELANOCYTIC NEVUS SYNDROME, CONGENITAL

NRAS HRAS

3.05e-062522137550
DiseaseLarge congenital melanocytic nevus

NRAS HRAS

3.05e-062522cv:C1842036
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

KRAS NRAS HRAS

4.90e-0619523C3501846
DiseaseCostello syndrome (disorder)

KRAS NRAS HRAS

4.90e-0619523C0587248
DiseaseNoonan syndrome-like disorder with loose anagen hair

KRAS NRAS HRAS

4.90e-0619523C1843181
Diseaseleukemia (implicated_via_orthology)

KRAS NRAS HRAS

4.90e-0619523DOID:1240 (implicated_via_orthology)
DiseaseCardio-facio-cutaneous syndrome

KRAS NRAS HRAS

4.90e-0619523C1275081
DiseaseLEOPARD Syndrome

KRAS NRAS HRAS

7.76e-0622523C0175704
DiseaseGIANT PIGMENTED HAIRY NEVUS

NRAS HRAS

9.13e-063522C1842036
DiseaseNoonan Syndrome

KRAS NRAS HRAS

1.02e-0524523C0028326
DiseasePapillary thyroid carcinoma

KRAS NRAS HRAS CCDC6

1.64e-0586524C0238463
DiseaseNevus, Keratinocytic, Nonepidermolytic

NRAS HRAS

1.82e-054522C4011754
DiseaseBLADDER CANCER

KRAS HRAS

1.82e-054522109800
DiseaseEpidermal nevus

NRAS HRAS

1.82e-054522cv:C0334082
DiseaseMalignant tumor of urinary bladder

KRAS HRAS

1.82e-054522cv:C0005684
DiseaseNEVUS, EPIDERMAL

NRAS HRAS

1.82e-054522162900
DiseaseThyroid cancer, nonmedullary, 2

NRAS HRAS

1.82e-054522cv:C4225426
DiseaseMalignant neoplasm of penis

KRAS HRAS

1.82e-054522C0153601
DiseasePenile Neoplasms

KRAS HRAS

1.82e-054522C0030849
DiseaseMalignant tumor of cervix

KRAS HRAS

1.82e-054522C0007847
Diseaseepidermal nevus (is_implicated_in)

NRAS HRAS

1.82e-054522DOID:0111162 (is_implicated_in)
DiseaseTHYROID CANCER, NONMEDULLARY, 2

NRAS HRAS

1.82e-054522188470
Diseasehypertrophic cardiomyopathy (implicated_via_orthology)

KRAS NRAS HRAS

1.83e-0529523DOID:11984 (implicated_via_orthology)
Diseasecolorectal cancer (implicated_via_orthology)

KRAS NRAS HRAS

2.03e-0530523DOID:9256 (implicated_via_orthology)
Diseaseintestinal cancer (implicated_via_orthology)

KRAS NRAS HRAS

2.47e-0532523DOID:10155 (implicated_via_orthology)
Diseaseprostate cancer (implicated_via_orthology)

KRAS NRAS HRAS

2.71e-0533523DOID:10283 (implicated_via_orthology)
DiseaseTHYROID CANCER, NONMEDULLARY, 2

NRAS HRAS

3.04e-055522C4225426
DiseaseMalignant neoplasm of thyroid

KRAS NRAS

3.04e-055522C0007115
DiseaseCetuximab response

KRAS NRAS

3.04e-055522cv:CN077967
DiseaseCervix carcinoma

KRAS HRAS

3.04e-055522C0302592
DiseasePanitumumab response

KRAS NRAS

3.04e-055522cv:CN077999
DiseaseThyroid Neoplasm

KRAS NRAS HRAS

3.84e-0537523C0040136
Diseasedietary heme iron intake measurement, type 2 diabetes mellitus

MUSK SVEP1

4.55e-056522EFO_0008355, MONDO_0005148
DiseaseAutoimmune lymphoproliferative syndrome

KRAS NRAS

4.55e-056522cv:CN301239
DiseaseCarcinoma in situ of uterine cervix

KRAS HRAS

4.55e-056522C0851140
Diseaselevel of Phosphatidylcholine (18:2_0:0) in blood serum

PARD3B MUSK

4.55e-056522OBA_2045105
Diseaseseminoma (is_implicated_in)

KRAS HRAS

4.55e-056522DOID:4440 (is_implicated_in)
DiseasePleocytosis

KRAS NRAS

4.55e-056522C0151857
DiseaseLeukocytosis

KRAS NRAS

4.55e-056522C0023518
DiseaseThyroid cancer, follicular

NRAS HRAS

6.36e-057522C2931367
Diseasehigh grade glioma (implicated_via_orthology)

KRAS NRAS HRAS

6.50e-0544523DOID:3070 (implicated_via_orthology)
DiseaseThyroid carcinoma

KRAS NRAS HRAS

6.50e-0544523C0549473
DiseaseNeuroblastoma

KRAS NRAS HRAS

7.92e-0547523C0027819
DiseaseAlzheimer's disease biomarker measurement, brain volume measurement

KRAS NRAS

8.47e-058522EFO_0006514, EFO_0006930
DiseaseNoonan syndrome

KRAS NRAS

1.09e-049522cv:C0028326
Disease1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4) measurement

MINDY2 MUSK

1.09e-049522EFO_0800409
Diseasethyroid gland papillary carcinoma (is_implicated_in)

NRAS HRAS

1.36e-0410522DOID:3969 (is_implicated_in)
Diseaseentorhinal cortical volume, Alzheimer's disease biomarker measurement

KRAS NRAS

1.66e-0411522EFO_0005092, EFO_0006514
Diseasemetabolite measurement, body weight gain

ZCCHC7 MUSK

1.99e-0412522EFO_0004566, EFO_0004725
Diseasecarcinoma (implicated_via_orthology)

KRAS NRAS HRAS

1.99e-0464523DOID:305 (implicated_via_orthology)
DiseaseNeoplasms, Experimental

KRAS NRAS HRAS

2.18e-0466523C0027659
Diseasemiddle temporal gyrus volume measurement, Alzheimer's disease biomarker measurement

KRAS NRAS

2.35e-0413522EFO_0006514, EFO_0010316
Diseasecardiomyopathy (implicated_via_orthology)

KRAS NRAS HRAS

2.71e-0471523DOID:0050700 (implicated_via_orthology)
Diseasedysmenorrheic pain measurement

KRAS NRAS

3.60e-0416522EFO_0007889
DiseaseHemangiosarcoma

KRAS HRAS

4.58e-0418522C0018923
Diseaselevel of Phosphatidylethanolamine (18:0_20:4) in blood serum

MINDY2 MUSK

5.11e-0419522OBA_2045140
DiseaseJuvenile Myelomonocytic Leukemia

KRAS NRAS

5.11e-0419522C0349639
DiseaseAdenocarcinoma of large intestine

KRAS NRAS HRAS

6.57e-0496523C1319315
DiseaseSplenomegaly

KRAS NRAS

6.88e-0422522C0038002
DiseaseCarcinoma of lung

KRAS CSNK2A3

7.53e-0423522C0684249
DiseaseNeoplasm of the genitourinary tract

KRAS HRAS

8.20e-0424522cv:C0042065
Diseaseglioblastoma (is_implicated_in)

NRAS RPL5

8.20e-0424522DOID:3068 (is_implicated_in)
Diseaseparacentral lobule volume measurement

KRAS NRAS

8.90e-0425522EFO_0010317
DiseaseAlzheimer's disease (is_marker_for)

CSNK1A1 HRAS PPP1R9B STOX1

1.10e-03257524DOID:10652 (is_marker_for)
Diseasecancer (implicated_via_orthology)

KRAS NRAS HRAS PIP4K2C

1.28e-03268524DOID:162 (implicated_via_orthology)
DiseaseAdult T-Cell Lymphoma/Leukemia

CSNK1A1 CSNK2A1

1.37e-0331522C0023493
DiseaseSquamous cell carcinoma

KRAS CSNK2A1 HRAS

1.38e-03124523C0007137
DiseaseMalignant Neoplasms

KRAS NRAS HRAS

1.51e-03128523C0006826
DiseaseCardiomyopathies

KRAS NRAS HRAS

1.58e-03130523C0878544
DiseaseThyroid Gland Follicular Adenoma

KRAS HRAS

1.75e-0335522C0151468
DiseaseUterine Cervical Neoplasm

KRAS HRAS

1.75e-0335522C0007873
Diseaselate-onset Alzheimers disease

KRAS NRAS CSNK2A1 MINDY2

1.75e-03292524EFO_1001870

Protein segments in the cluster

PeptideGeneStartEntry
YMEFDLNNEGEIDLM

AIF1L

56

Q9BQI0
MEYVYEDVDGQTEVM

EP400

2231

Q96L91
YGRYGDNVEEMDWMV

ARSH

286

Q5FYA8
YSMQEMYDVVSGVED

COQ10B

86

Q9H8M1
GRYMELEQRYMDLAE

SPECC1L

486

Q69YQ0
MDDERYFNEMSAQGL

CCDC6

331

Q16204
RSGYDYSELDPEMEM

AKAP8L

141

Q9ULX6
YSELDPEMEMAYEGQ

AKAP8L

146

Q9ULX6
QEEYSAMRDQYMRTG

HRAS

61

P01112
QEEYSAMRDQYMRTG

KRAS

61

P01116
QEEYSAMRDQYMRTG

NRAS

61

P01111
EMGAYGYEDLQQRVM

OLFM2

166

O95897
IQMDARAGETMYLYE

ECT2

341

Q9H8V3
MEEMRDSYLEEDVYQ

MTCL1

361

Q9Y4B5
YDMLQMDYATNTQDE

PARP2

201

Q9UGN5
MADEAFMNAVQSYYE

CADPS

171

Q9ULU8
EMLEEGQEYAVMLYT

CYFIP1

71

Q7L576
VYDMDDDEMDPNYAR

PARD3B

941

Q8TEW8
MMQDISNNEYLEYGS

CASK

796

O14936
DERSFQYADIYEQMM

MAP1A

1961

P78559
NYFGEDDMYMDFEEV

KIAA1109

751

Q2LD37
QAMVLEMFREEDYYN

NLRX1

576

Q86UT6
LYMQEVERMDGYGEE

PTPN21

206

Q16825
NNEYGEMEAERLAAM

PDP2

481

Q9P2J9
ELLVDYQMYDYSLDM

CSNK2A3

201

Q8NEV1
GFQMLYADCYMNREE

DHCR24

466

Q15392
QMIVRRYANEDGDMD

CAPNS2

191

Q96L46
VEYYDGDMFRMDNCR

CRIM1

341

Q9NZV1
ELLVDYQMYDYSLDM

CSNK2A1

201

P68400
YDDETYMMQDVAEEQ

ELF2

56

Q15723
YDYINSNRSEEMDMD

MAP3K20

91

Q9NYL2
MDLECSRDGLMYEQY

EXOC3

146

O60645
LGMYRVSVDNEDSYM

PIP4K2C

186

Q8TBX8
TAEQLMEYLGDYMLD

MINDY2

291

Q8NBR6
RDDMESLGYVLMYFN

CSNK1A1

201

P48729
GQNVADYMRYLMEED

RPL5

201

P46777
QGYFEQEDDMMEVPY

SVEP1

2631

Q4LDE5
IDNYEEDYQKMRDMG

SPTBN1

1111

Q01082
LLVGDMAYYDFNGEM

ADD2

251

P35612
MAYYDFNGEMEQEAD

ADD2

256

P35612
MRMEDEDYNTSISYG

CMKLR1

1

Q99788
MDGLDDVENSMLYYN

CNOT10

101

Q9H9A5
AMAEWYMRGEQYDQA

CNOT1

541

A5YKK6
AQMLQMEYDREYDAQ

RIOK3

81

O14730
RLNDDGYLEMSDMNE

ZSWIM5

621

Q9P217
MDELGYMYFRDRSGD

SLC27A1

496

Q6PCB7
DAMLDTYDLVYEQAM

TSPAN32

121

Q96QS1
MESMLRYEVYGGENE

STOX1

601

Q6ZVD7
MLEMRDVYMEEDVYQ

SOGA1

1

O94964
QPEDEAMYYCAMGAR

VPREB1

106

P12018
YILFYEQMDMIDEDD

USP9Y

1951

O00507
VDGYMNMQLANTEEY

SNRPF

36

P62306
MMFGGYETIEAYEDD

ZCCHC7

1

Q8N3Z6
MDCREMDLYEDYQSP

TPD52

1

P55327
DEEDYVEMKEQMYQD

SUDS3

61

Q9H7L9
IVVMMYDDIAYSEDN

LGMN

66

Q99538
EYMAYGDLNEFLRSM

MUSK

656

O15146
REMMEQRYAQYGEDD

PPP1R9B

606

Q96SB3