Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cholesterol dehydrogenase activity	HSD3B1 HSD3B2	2.19e-05	2	94	2	GO:0102294
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GABRG2 HTR1B GRIA1 GRM5 CHRNA4	1.10e-04	100	94	5	GO:0030594
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	GRIA1 GRM5	1.31e-04	4	94	2	GO:0099583
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	RAB9B ABCC4 RAB9A ATP2C1 IQCA1 ABCA5 DYNC2H1 ENTPD1 GNL2 MSH2 RABL3 RAD17	2.77e-04	775	94	12	GO:0017111
GeneOntologyMolecularFunction	3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity	HSD3B1 HSD3B2	3.25e-04	6	94	2	GO:0003854
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	GABRG2 GRIA1 GRM5 CHRNA4	4.34e-04	75	94	4	GO:0098960
GeneOntologyMolecularFunction	steroid delta-isomerase activity	HSD3B1 HSD3B2	4.53e-04	7	94	2	GO:0004769
GeneOntologyMolecularFunction	pyrophosphatase activity	RAB9B ABCC4 RAB9A ATP2C1 IQCA1 ABCA5 DYNC2H1 ENTPD1 GNL2 MSH2 RABL3 RAD17	5.64e-04	839	94	12	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	RAB9B ABCC4 RAB9A ATP2C1 IQCA1 ABCA5 DYNC2H1 ENTPD1 GNL2 MSH2 RABL3 RAD17	5.70e-04	840	94	12	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	RAB9B ABCC4 RAB9A ATP2C1 IQCA1 ABCA5 DYNC2H1 ENTPD1 GNL2 MSH2 RABL3 RAD17	5.70e-04	840	94	12	GO:0016818
GeneOntologyMolecularFunction	5alpha-androstane-3beta,17beta-diol dehydrogenase activity	HSD3B1 HSD3B2	6.03e-04	8	94	2	GO:0047024
GeneOntologyMolecularFunction	3-keto sterol reductase activity	HSD3B1 HSD3B2	6.03e-04	8	94	2	GO:0000253
GeneOntologyMolecularFunction	ATP-dependent activity	ABCC4 SETX ATP2C1 IQCA1 ABCA5 DYNC2H1 DNAH17 ENTPD1 MSH2 RAD17	6.24e-04	614	94	10	GO:0140657
GeneOntologyMolecularFunction	histone modifying activity	SLK NAA60 SETD5 NSD1 CHEK1 OGA	7.49e-04	229	94	6	GO:0140993
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCC4 ATP2C1 IQCA1 ABCA5 DYNC2H1 ENTPD1 MSH2 RAD17	1.13e-03	441	94	8	GO:0016887
GeneOntologyMolecularFunction	RNA polymerase I core promoter sequence-specific DNA binding	UBTFL1 TAF1B	1.17e-03	11	94	2	GO:0001164
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	NEK4 TGFBR2 STK10 SLK CAMK1D PAK5 CHEK1 CHUK	1.21e-03	446	94	8	GO:0004674
GeneOntologyMolecularFunction	RNA polymerase I transcription regulatory region sequence-specific DNA binding	UBTFL1 TAF1B	1.65e-03	13	94	2	GO:0001163
GeneOntologyMolecularFunction	histone H3K36 methyltransferase activity	SETD5 NSD1	1.65e-03	13	94	2	GO:0046975
HumanPheno	Colon cancer	TGFBR2 RPS19 MSH2 MBD4 RABL3	9.61e-06	39	39	5	HP:0003003
Domain	PKK	STK10 SLK	2.35e-05	2	91	2	PF12474
Domain	PKK	STK10 SLK	2.35e-05	2	91	2	IPR022165
Domain	Protein_kinase_ATP_BS	NEK4 TGFBR2 STK10 SLK CAMK1D PAK5 CHEK1 EPHA1 CHUK	9.60e-05	379	91	9	IPR017441
Domain	3Beta_OHSteriod_DH/Estase	HSD3B1 HSD3B2	3.48e-04	6	91	2	IPR002225
Domain	3Beta_HSD	HSD3B1 HSD3B2	3.48e-04	6	91	2	PF01073
Domain	Ser/Thr_kinase_AS	NEK4 TGFBR2 STK10 SLK CAMK1D PAK5 CHEK1 CHUK	3.52e-04	357	91	8	IPR008271
Domain	S_TKc	NEK4 TGFBR2 STK10 SLK CAMK1D PAK5 CHEK1 CHUK	3.66e-04	359	91	8	SM00220
Domain	PROTEIN_KINASE_ST	NEK4 TGFBR2 STK10 SLK CAMK1D PAK5 CHEK1 CHUK	3.87e-04	362	91	8	PS00108
Domain	PROTEIN_KINASE_ATP	NEK4 TGFBR2 STK10 SLK CAMK1D PAK5 CHEK1 EPHA1 CHUK	3.99e-04	459	91	9	PS00107
Domain	Pkinase	NEK4 TGFBR2 STK10 SLK CAMK1D PAK5 CHEK1 CHUK	5.42e-04	381	91	8	PF00069
Domain	Prot_kinase_dom	NEK4 TGFBR2 STK10 SLK CAMK1D PAK5 CHEK1 EPHA1 CHUK	6.29e-04	489	91	9	IPR000719
Domain	PROTEIN_KINASE_DOM	NEK4 TGFBR2 STK10 SLK CAMK1D PAK5 CHEK1 EPHA1 CHUK	6.66e-04	493	91	9	PS50011
Domain	-	RAB9B ABCC4 RAB9A SETX IQCA1 ABCA5 DYNC2H1 GNL2 MSH2 RABL3 RAD17	9.90e-04	746	91	11	3.40.50.300
Domain	Galactose-bd-like	PTPRM F5 DCBLD2 EPHA1	1.15e-03	94	91	4	IPR008979
Domain	Kinase-like_dom	NEK4 TGFBR2 STK10 SLK CAMK1D PAK5 CHEK1 EPHA1 CHUK	1.30e-03	542	91	9	IPR011009
Domain	SET_dom	PRDM10 SETD5 NSD1	1.86e-03	50	91	3	IPR001214
Domain	SET	PRDM10 SETD5 NSD1	1.86e-03	50	91	3	PS50280
Domain	WD_REPEATS_1	WDR93 DYNC2I1 MAPKBP1 CFAP44 PPWD1 TBL2	2.39e-03	278	91	6	PS00678
Domain	WD_REPEATS_2	WDR93 DYNC2I1 MAPKBP1 CFAP44 PPWD1 TBL2	2.43e-03	279	91	6	PS50082
Domain	WD_REPEATS_REGION	WDR93 DYNC2I1 MAPKBP1 CFAP44 PPWD1 TBL2	2.43e-03	279	91	6	PS50294
Domain	P-loop_NTPase	RAB9B ABCC4 RAB9A SETX IQCA1 ABCA5 DYNC2H1 GNL2 MSH2 RABL3 RAD17	2.73e-03	848	91	11	IPR027417
Domain	WD40_repeat_dom	WDR93 DYNC2I1 MAPKBP1 CFAP44 PPWD1 TBL2	3.31e-03	297	91	6	IPR017986
Domain	FA58C	F5 DCBLD2	4.64e-03	21	91	2	SM00231
Domain	FA58C_3	F5 DCBLD2	4.64e-03	21	91	2	PS50022
Domain	FA58C_1	F5 DCBLD2	4.64e-03	21	91	2	PS01285
Domain	FA58C_2	F5 DCBLD2	4.64e-03	21	91	2	PS01286
Domain	AAA+_ATPase	ABCC4 ABCA5 DYNC2H1 RAD17	5.39e-03	144	91	4	IPR003593
Domain	AAA	ABCC4 ABCA5 DYNC2H1 RAD17	5.39e-03	144	91	4	SM00382
Domain	-	F5 DCBLD2 EPHA1	5.44e-03	73	91	3	2.60.120.260
Domain	RAB	RAB9B RAB9A RABL3	5.44e-03	73	91	3	PS51419
Domain	-	WDR93 DYNC2I1 MAPKBP1 CFAP44 PPWD1 TBL2	5.76e-03	333	91	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR93 DYNC2I1 MAPKBP1 CFAP44 PPWD1 TBL2	5.92e-03	335	91	6	IPR015943
Domain	F5_F8_type_C	F5 DCBLD2	6.04e-03	24	91	2	PF00754
Domain	FA58C	F5 DCBLD2	6.04e-03	24	91	2	IPR000421
Domain	WD40	DYNC2I1 MAPKBP1 CFAP44 PPWD1 TBL2	8.72e-03	259	91	5	PF00400
Pubmed	PTEN identified as important risk factor of chronic obstructive pulmonary disease.	IL12B ABCC4 HTR1B ABCA5 HSD3B1 HSD3B2 MSH2 CHEK1 MBD4 HIF1AN	8.24e-08	374	95	10	19625176
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	IL12B ABCC4 HTR1B ABCA5 HSD3B1 HSD3B2 MSH2 CHEK1 MBD4 HIF1AN	9.78e-08	381	95	10	18676680
Pubmed	Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.	IL12B ABCC4 HTR1B ABCA5 HSD3B1 HSD3B2 MSH2 CHEK1 MBD4 HIF1AN	1.00e-07	382	95	10	19170196
Pubmed	Genetic susceptibility to distinct bladder cancer subphenotypes.	IL12B ABCC4 HTR1B ABCA5 HSD3B1 HSD3B2 MSH2 CHEK1 MBD4 HIF1AN	2.46e-07	421	95	10	19692168
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	SLK POLR3B DYNC2H1 IGHM TAF1B GNL2 MSH2 FUCA1 MTCL1 NUDCD1 OGA HIF1AN TBL2 RAD17	6.02e-07	1005	95	14	19615732
Pubmed	MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation.	MSH2 CHEK1 RAD17	1.09e-06	8	95	3	14657349
Pubmed	Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol.	HSD3B1 HSD3B2	7.38e-06	2	95	2	14665668
Pubmed	Chaperones rejuvenate folding and activity of 3-β hydroxysteroid dehydrogenase 2.	HSD3B1 HSD3B2	7.38e-06	2	95	2	23485106
Pubmed	Structure/function of the inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 and type 2 by trilostane.	HSD3B1 HSD3B2	7.38e-06	2	95	2	18524572
Pubmed	Regulation of 3beta-hydroxysteroid dehydrogenase type 1 and type 2 gene expression and function in the human ovarian surface epithelium by cytokines.	HSD3B1 HSD3B2	7.38e-06	2	95	2	19414525
Pubmed	3beta-Hydroxysteroid dehydrogenases and pre-receptor steroid metabolism in the human ovarian surface epithelium.	HSD3B1 HSD3B2	7.38e-06	2	95	2	18778748
Pubmed	Structure-function relationships of 3 beta-hydroxysteroid dehydrogenase: contribution made by the molecular genetics of 3 beta-hydroxysteroid dehydrogenase deficiency.	HSD3B1 HSD3B2	7.38e-06	2	95	2	9029734
Pubmed	The multiple murine 3 beta-hydroxysteroid dehydrogenase isoforms: structure, function, and tissue- and developmentally specific expression.	HSD3B1 HSD3B2	7.38e-06	2	95	2	9029733
Pubmed	Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells.	HSD3B1 HSD3B2	7.38e-06	2	95	2	2243100
Pubmed	Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity.	HSD3B1 HSD3B2	7.38e-06	2	95	2	12205101
Pubmed	Immunolocalization of murine type VI 3β-hydroxysteroid dehydrogenase in the adrenal gland, testis, skin, and placenta.	HSD3B1 HSD3B2	7.38e-06	2	95	2	24075909
Pubmed	3β-Hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma.	HSD3B1 HSD3B2	7.38e-06	2	95	2	25458695
Pubmed	A novel nonstop mutation in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase (3beta-HSD) gene causing, respectively, nonclassic and classic 3beta-HSD deficiency congenital adrenal hyperplasia.	HSD3B1 HSD3B2	7.38e-06	2	95	2	12050213
Pubmed	Immunohistochemical localization of the 11 beta-hydroxysteroid dehydrogenase type II enzyme in human kidney and placenta.	HSD3B1 HSD3B2	7.38e-06	2	95	2	7608280
Pubmed	Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure.	HSD3B1 HSD3B2	7.38e-06	2	95	2	20660004
Pubmed	Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals.	IGHM CHUK	7.38e-06	2	95	2	17404218
Pubmed	Low-dose radiation-induced demethylation of 3β-HSD participated in the regulation of testosterone content.	HSD3B1 HSD3B2	7.38e-06	2	95	2	34550611
Pubmed	The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2.	IGHM MSH2	7.38e-06	2	95	2	14563316
Pubmed	Rab9 GTPase is required for replication of human immunodeficiency virus type 1, filoviruses, and measles virus.	RAB9B RAB9A	7.38e-06	2	95	2	16140752
Pubmed	The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency.	HSD3B1 HSD3B2	7.38e-06	2	95	2	14764797
Pubmed	High carrier frequency of a nonsense p.Trp230* variant in HSD3B2 gene in Ossetians.	HSD3B1 HSD3B2	7.38e-06	2	95	2	37274334
Pubmed	Multiple forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase and differential expression in gonads, adrenal glands, liver, and kidneys of both sexes.	HSD3B1 HSD3B2	7.38e-06	2	95	2	1924345
Pubmed	Effects of water restriction on gene expression in mouse renal medulla: identification of 3betaHSD4 as a collecting duct protein.	HSD3B1 HSD3B2	7.38e-06	2	95	2	16478974
Pubmed	Three populations of adult Leydig cells in mouse testes revealed by a novel mouse HSD3B1-specific rat monoclonal antibody.	HSD3B1 HSD3B2	7.38e-06	2	95	2	30851938
Pubmed	Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression.	HTR1B GRIA1	7.38e-06	2	95	2	23502536
Pubmed	The murine 3 beta-hydroxysteroid dehydrogenase multigene family: structure, function and tissue-specific expression.	HSD3B1 HSD3B2	7.38e-06	2	95	2	7626443
Pubmed	Activity and substrate specificity of the murine STK2 Serine/Threonine kinase that is structurally related to the mitotic regulator protein NIMA of Aspergillus nidulans.	NEK4 SLK	7.38e-06	2	95	2	10529384
Pubmed	A novel mouse kidney 3 beta-hydroxysteroid dehydrogenase complementary DNA encodes a 3-ketosteroid reductase instead of a 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase.	HSD3B1 HSD3B2	7.38e-06	2	95	2	8145763
Pubmed	Equine P450 cholesterol side-chain cleavage and 3 beta-hydroxysteroid dehydrogenase/delta(5)-delta(4) isomerase: molecular cloning and regulation of their messenger ribonucleic acids in equine follicles during the ovulatory process.	HSD3B1 HSD3B2	7.38e-06	2	95	2	11133676
Pubmed	Regional chromosomal assignment of human 3-beta-hydroxy-5-ene steroid dehydrogenase to 1p13.1 by non-isotopic in situ hybridisation.	HSD3B1 HSD3B2	7.38e-06	2	95	2	2066113
Pubmed	Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility.	HSD3B1 HSD3B2	7.38e-06	2	95	2	11912155
Pubmed	Association of the variations in the HSD3β gene with primary aldosteronism.	HSD3B1 HSD3B2	7.38e-06	2	95	2	24006038
Pubmed	New mutations in DYNC2H1 and WDR60 genes revealed by whole-exome sequencing in two unrelated Sardinian families with Jeune asphyxiating thoracic dystrophy.	DYNC2H1 DYNC2I1	7.38e-06	2	95	2	26874042
Pubmed	Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads.	HSD3B1 HSD3B2	7.38e-06	2	95	2	1944309
Pubmed	Expression of multiple forms of 3 beta-hydroxysteroid dehydrogenase in the mouse liver during fetal and postnatal development.	HSD3B1 HSD3B2	7.38e-06	2	95	2	8647315
Pubmed	The mouse 3 beta-hydroxysteroid dehydrogenase multigene family includes two functionally distinct groups of proteins.	HSD3B1 HSD3B2	7.38e-06	2	95	2	7491113
Pubmed	Differences in substrate and inhibitor kinetics of human type 1 and type 2 3beta-hydroxysteroid dehydrogenase are explained by the type 1 mutant, H156Y.	HSD3B1 HSD3B2	7.38e-06	2	95	2	12530651
Pubmed	Multiple epithelial and nonepithelial tumors in hereditary nonpolyposis colorectal cancer: characterization of germline and somatic mutations of the MSH2 gene and heterogeneity of replication error phenotypes.	TGFBR2 MSH2	7.38e-06	2	95	2	15350299
Pubmed	Isolation and characterization of several members of the murine Hsd3b gene family.	HSD3B1 HSD3B2	7.38e-06	2	95	2	8924213
Pubmed	Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice.	TGFBR2 IL12B	7.38e-06	2	95	2	19676134
Pubmed	Expression of 3beta-hydroxysteroid dehydrogenase type I and type VI isoforms in the mouse testis during development.	HSD3B1 HSD3B2	7.38e-06	2	95	2	10103023
Pubmed	Isolation of a new mouse 3beta-hydroxysteroid dehydrogenase isoform, 3beta-HSD VI, expressed during early pregnancy.	HSD3B1 HSD3B2	7.38e-06	2	95	2	9075693
Pubmed	Human 3beta-hydroxysteroid dehydrogenase types 1 and 2: Gene sequence variation and functional genomics.	HSD3B1 HSD3B2	7.38e-06	2	95	2	17689071
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	NEK4 TGFBR2 BMP3 HSD3B1 HSD3B2 F5 CHRNA4	1.09e-05	275	95	7	20734064
Pubmed	Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2.	MSH2 CHEK1	2.21e-05	3	95	2	15647386
Pubmed	AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma.	IGHM MSH2	2.21e-05	3	95	2	26385350
Pubmed	Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-Myc-induced lymphomas.	IGHM MSH2	2.21e-05	3	95	2	19837692
Pubmed	Complex relationship between mismatch repair proteins and MBD4 during immunoglobulin class switch recombination.	MSH2 MBD4	2.21e-05	3	95	2	24205214
Pubmed	Expression of LH receptor in nonpregnant mouse endometrium: LH induction of 3β-HSD and de novo synthesis of progesterone.	HSD3B1 HSD3B2	2.21e-05	3	95	2	22875961
Pubmed	Lymphoma-like T cell infiltration in liver is associated with increased copy number of dominant negative form of TGFβ receptor II.	TGFBR2 IL12B	2.21e-05	3	95	2	23145171
Pubmed	Estrogen synthesis genes CYP19A1, HSD3B1, and HSD3B2 in hypertensive disorders of pregnancy.	HSD3B1 HSD3B2	2.21e-05	3	95	2	22638611
Pubmed	Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2.	RAB9B RAB9A	2.21e-05	3	95	2	25220469
Pubmed	Orexin-A stimulates 3β-hydroxysteroid dehydrogenase expression and cortisol production in H295R human adrenocortical cells through the AKT pathway.	HSD3B1 HSD3B2	2.21e-05	3	95	2	25319929
Pubmed	Hypoxia-inducible factor-1alpha is constitutively expressed in murine Leydig cells and regulates 3beta-hydroxysteroid dehydrogenase type 1 promoter activity.	HSD3B1 HSD3B2	2.21e-05	3	95	2	18930903
Pubmed	Ubiquitin-specific peptidase 20 regulates Rad17 stability, checkpoint kinase 1 phosphorylation and DNA repair by homologous recombination.	CHEK1 RAD17	2.21e-05	3	95	2	24923443
Pubmed	Loss of MMR and TGFBR2 Increases the Susceptibility to Microbiota-Dependent Inflammation-Associated Colon Cancer.	TGFBR2 MSH2	2.21e-05	3	95	2	35688320
Pubmed	Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.	STK10 SLK	2.21e-05	3	95	2	23209304
Pubmed	Modulation of steroidogenic enzymes in murine lymphoid organs after immune activation.	HSD3B1 HSD3B2	2.21e-05	3	95	2	19172483
Pubmed	A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.	RPS19 MSH2 CHEK1 RAD17	3.11e-05	65	95	4	27453043
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TGFBR2 SLK RAB9A PHPT1 PTPRM DYNC2H1 KIAA0232 RABL3 MYRF DCBLD2 TBL2 RAD17	3.26e-05	1061	95	12	33845483
Pubmed	Germline mutation analysis of the transforming growth factor beta receptor type II (TGFBR2) and E-cadherin (CDH1) genes in early onset and familial colorectal cancer.	TGFBR2 MSH2	4.41e-05	4	95	2	11158177
Pubmed	RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport.	RAB9B RAB9A	4.41e-05	4	95	2	19490898
Pubmed	Changes in subcellular localization of metabotropic glutamate receptor subtypes during postnatal development of mouse thalamus.	GRIA1 GRM5	4.41e-05	4	95	2	9619499
Pubmed	Hypertension due to loss of clock: novel insight from the molecular analysis of Cry1/Cry2-deleted mice.	HSD3B1 HSD3B2	4.41e-05	4	95	2	21286865
Pubmed	AP-2 gamma and the homeodomain protein distal-less 3 are required for placental-specific expression of the murine 3 beta-hydroxysteroid dehydrogenase VI gene, Hsd3b6.	HSD3B1 HSD3B2	4.41e-05	4	95	2	11773066
Pubmed	Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.	STK10 SLK	4.41e-05	4	95	2	18239682
Pubmed	Hormonal regulation of steroidogenic enzyme gene expression in Leydig cells.	HSD3B1 HSD3B2	4.41e-05	4	95	2	22217834
Pubmed	Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6.	HSD3B1 HSD3B2	4.41e-05	4	95	2	20023637
Pubmed	An mRNA differential display strategy for cloning genes expressed during mouse gonad development.	HSD3B1 HSD3B2	4.41e-05	4	95	2	9303351
Pubmed	Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction.	HSD3B1 HSD3B2	4.41e-05	4	95	2	37117756
Pubmed	Prevention of allergen-specific, Th2-biased immune responses in vivo: role of increased IL-12 and IL-18 responsiveness.	IL12B IGHM	4.41e-05	4	95	2	16210597
Pubmed	R-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxias.	SETX TDP1	4.41e-05	4	95	2	24637776
Pubmed	RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36.	RAB9B RAB9A	4.41e-05	4	95	2	22637480
Pubmed	Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats.	IGHM MSH2	4.41e-05	4	95	2	19553545
Pubmed	Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9.	RAB9B RAB9A	4.41e-05	4	95	2	20048159
Pubmed	Brain-derived neurotrophic factor: A steroidogenic regulator of Leydig cells.	HSD3B1 HSD3B2	4.41e-05	4	95	2	30628054
Pubmed	Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins.	RAB9B RAB9A	4.41e-05	4	95	2	12051767
Pubmed	A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.	STK10 SLK	4.41e-05	4	95	2	27919044
Pubmed	Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer.	MSH2 CHEK1 MBD4	4.90e-05	26	95	3	20731661
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	IL12B HSD3B1 HSD3B2 MSH2 CHEK1 MBD4 HIF1AN	5.19e-05	351	95	7	20453000
Pubmed	Analyzing tumor suppressor activities in the murine small intestine.	MSH2 MBD4	7.34e-05	5	95	2	12725522
Pubmed	Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.	DYNC2H1 DYNC2I1	7.34e-05	5	95	2	25830415
Pubmed	Essential role for epidermal growth factor receptor in glutamate receptor signaling to NF-kappaB.	GRM5 CHUK	7.34e-05	5	95	2	18541671
Pubmed	Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations.	TGFBR2 TAF1B	7.34e-05	5	95	2	19503063
Pubmed	Initiation of steroidogenesis precedes expression of cholesterologenic enzymes in the fetal mouse testes.	HSD3B1 HSD3B2	7.34e-05	5	95	2	19793088
Pubmed	Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8+ T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation.	TGFBR2 ENTPD1	7.34e-05	5	95	2	34335618
Pubmed	Interaction of WDR60 intermediate chain with TCTEX1D2 light chain of the dynein-2 complex is crucial for ciliary protein trafficking.	DYNC2H1 DYNC2I1	7.34e-05	5	95	2	29742051
Pubmed	RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex.	PEBP1 CHUK	7.34e-05	5	95	2	20043910
Pubmed	Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells.	CHEK1 RAD17	7.34e-05	5	95	2	16951182
Pubmed	Cell- rather than antibody-mediated immunity leads to the development of profound thrombocytopenia during experimental Plasmodium berghei malaria.	IL12B IGHM	7.34e-05	5	95	2	16301680
Pubmed	A potential role for zinc transporter 7 in testosterone synthesis in mouse Leydig tumor cells.	HSD3B1 HSD3B2	7.34e-05	5	95	2	27121848
Pubmed	ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice.	HSD3B1 HSD3B2	7.34e-05	5	95	2	23874215
Pubmed	High-throughput mapping of a dynamic signaling network in mammalian cells.	TGFBR2 KLHL1 CHEK1 TBL2 EPHA1 CHUK	8.21e-05	260	95	6	15761153
Pubmed	Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA.	CHEK1 RAD17	1.10e-04	6	95	2	14624239
Pubmed	Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation.	PEBP1 CHUK	1.10e-04	6	95	2	11585904
Cytoband	Ensembl 112 genes in cytogenetic band chr10q24	SLK ENTPD1 OGA HIF1AN CHUK	4.81e-05	189	95	5	chr10q24
GeneFamily	WD repeat domain containing	WDR93 DYNC2I1 MAPKBP1 CFAP44 PPWD1 TBL2	1.26e-04	262	54	6	362
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HRGL2C	RAB9A IQCA1 GATM GRIA1 CFAP44 GRM5 THUMPD2 PI15 ARAP2	2.86e-06	325	95	9	M39053
Coexpression	GSE37532_TREG_VS_TCONV_CD4_TCELL_FROM_LN_DN	STK10 ABCC4 PHPT1 CLN5 RP2 IFNLR1 RAD17	8.49e-06	200	95	7	M8958
Coexpression	FINETTI_BREAST_CANCERS_KINOME_GRAY	NEK4 SLK CHUK	2.03e-05	15	95	3	M9693
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP	ABCC4 PRDM10 SETX ATP2C1 IGHM TAF1B ENTPD1 UQCRB ADI1 TDP1 MBD4 RABL3 TBL2 ARAP2 RAD17	3.04e-05	1215	95	15	M41122
Coexpression	KAUFFMANN_MELANOMA_RELAPSE_UP	MSH2 CHEK1 TDP1 RAD17	7.21e-05	61	95	4	M2431
Coexpression	GSE12845_IGD_POS_VS_NEG_BLOOD_BCELL_DN	PEBP1 FUCA1 CMAHP TBL2 JHY RAD17	8.10e-05	196	95	6	M3183
Coexpression	GSE3982_EOSINOPHIL_VS_BCELL_UP	TGFBR2 BMP3 CAMK1D NAA60 FUCA1 DCBLD2	8.81e-05	199	95	6	M5406
Coexpression	GSE3039_NKT_CELL_VS_B2_BCELL_UP	ABCC4 POLR3B SETX PTPRM PRG4 F5	9.05e-05	200	95	6	M6435
Coexpression	GSE26343_WT_VS_NFAT5_KO_MACROPHAGE_UP	SLK SETX NAA60 ENTPD1 ADI1 PCYOX1	9.05e-05	200	95	6	M8644
Coexpression	GSE17186_MEMORY_VS_CD21LOW_TRANSITIONAL_BCELL_UP	SYNRG SLK ENTPD1 MSH2 FUCA1 UQCRB	9.05e-05	200	95	6	M7180
ToppCell	(05)_Ciliated-(4)_1wkpi\|(05)_Ciliated / shred by cell type and Timepoint	SYNRG FXYD4 HSD3B2 NUDCD1 MAPKBP1 DCBLD2 JHY	1.20e-07	180	95	7	85fc9b164147b28545e2397d32302eea03ef6346
ToppCell	Epithelial-Epithelial-D_(Ciliated)\|Epithelial / shred on cell class and cell subclass (v4)	IQCA1 DYNC2H1 RGS22 DYNC2I1 SAXO2 CFAP44	3.14e-06	188	95	6	8f30535a32968a81a304315a49c0d90a77d36948
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WDR93 DYNC2H1 RGS22 DYNC2I1 SAXO2 CFAP44	4.11e-06	197	95	6	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WDR93 DYNC2H1 SAXO2 CFAP44 GRM5	3.11e-05	169	95	5	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	5'-Adult-LargeIntestine-Epithelial-neuro-epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EYS KLHL1 PAK5 F5 UNC13A	3.57e-05	174	95	5	9f114e61458659005b6d0b4aa30a7a059e7aa5c6
ToppCell	facs-Trachea-nan-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR93 IQCA1 RGS22 SAXO2 CFAP44	3.77e-05	176	95	5	ed788a5969edfd1199828ca5b0dd34e7f29c4d30
ToppCell	facs-Trachea-18m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell-ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	WDR93 IQCA1 RGS22 SAXO2 CFAP44	4.09e-05	179	95	5	d4efbc34f52136039b96451fd0b0a0ad164197c6
ToppCell	facs-Trachea-18m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	WDR93 IQCA1 RGS22 SAXO2 CFAP44	4.09e-05	179	95	5	8a66d197a2f55d763ff7ef0bec89ee96f59c3937
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR93 IQCA1 RGS22 SAXO2 CFAP44	4.42e-05	182	95	5	587636c0f127231de21acd8aa632b74ff22ca8c2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR93 IQCA1 RGS22 SAXO2 CFAP44	4.42e-05	182	95	5	adfadd7893e74b3002f13f00875e3667d3493e0c
ToppCell	Ciliated_cells-B-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	WDR93 DYNC2H1 RGS22 SAXO2 CFAP44	4.42e-05	182	95	5	e93968f800bfeb258e4e834fc8bf92d1cb72cd73
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR93 IQCA1 RGS22 CFAP44 JHY	4.54e-05	183	95	5	6ca7c2d7c56e0f1b9038ba677b4c1c3dfd63bfce
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR93 IQCA1 RGS22 CFAP44 JHY	4.54e-05	183	95	5	18040d0653286071df959513c63d94b555a5d00a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PEBP1 GATM UQCRB ADI1 CHRNA4	4.66e-05	184	95	5	2b83c7a808e97abf836f53aa3243543c8f6762fb
ToppCell	NS-critical-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IQCA1 DYNC2H1 RGS22 SAXO2 CFAP44	4.91e-05	186	95	5	76033438426d8f9c72cd6691a7baf92104c9f03d
ToppCell	droplet-Lung-nan-18m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR93 IQCA1 RGS22 SAXO2 CFAP44	4.91e-05	186	95	5	740fd06bcd3b24e6ff2ecf8080f378afc3e95084
ToppCell	droplet-Lung-nan-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR93 IQCA1 RGS22 SAXO2 CFAP44	4.91e-05	186	95	5	5ab43a298d23238b34e898d11decf0ad81d1b14e
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQCA1 RGS22 SAXO2 CFAP44 JHY	5.03e-05	187	95	5	04dba2ed09ee4180830bdf0191921696697ea234
ToppCell	facs-Lung-EPCAM-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQCA1 RGS22 SAXO2 CFAP44 JHY	5.03e-05	187	95	5	805dafe22f835ece4dd091d8030d0a63b52a48dd
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GATM HSD3B2 UQCRB CHRNA4 CHUK	5.16e-05	188	95	5	b483b4629695764568bcbd1d527d614824147783
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GATM HSD3B2 UQCRB CHRNA4 CHUK	5.16e-05	188	95	5	c1f64311ff05093b2f4f672e33f5f75e3bc8a8db
ToppCell	droplet-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	WDR93 IQCA1 RGS22 SAXO2 CFAP44	5.16e-05	188	95	5	0eca3dc93724e23b71e687fc24fa9f1e89bdef6a
ToppCell	facs-SCAT-Fat-3m\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBR2 RPS19 UQCRB CMAHP PI15	5.16e-05	188	95	5	b8dff61240e5052c2fbf7f28b86fe41822df45b0
ToppCell	droplet-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	WDR93 IQCA1 RGS22 SAXO2 CFAP44	5.16e-05	188	95	5	9ce3e1fffce87ad19812ecbf9b7f9935a975d676
ToppCell	Epithelial-D_(Ciliated)\|World / shred on cell class and cell subclass (v4)	IQCA1 RGS22 DYNC2I1 SAXO2 CFAP44	5.29e-05	189	95	5	0bf560b595c7a8450a46bc821b742b67965bd9f9
ToppCell	droplet-Lung-18m-Epithelial-airway_epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	WDR93 IQCA1 RGS22 SAXO2 CFAP44	5.29e-05	189	95	5	fe958fdf9963c2dfe270f67f0da36b3264d0017c
ToppCell	ILEUM-non-inflamed-(1)_Tregs\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	RAB9A ENTPD1 ETV7 UQCRB F5	5.56e-05	191	95	5	e065d16a1f88c91dec576d248a318534ceab1cb2
ToppCell	PND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IQCA1 RGS22 DYNC2I1 SAXO2 CFAP44	5.70e-05	192	95	5	b5cdc2dae3154b1e4ade88f841f38584402ffe33
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DYNC2H1 RGS22 DYNC2I1 SAXO2 CFAP44	5.84e-05	193	95	5	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-Treg\|T/NK_cells / Location, Cell class and cell subclass	CLN5 ENTPD1 ETV7 ADI1 F5	5.99e-05	194	95	5	e46963d5f156526342ebc0fb9e767d266e812c42
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2\|World / Primary Cells by Cluster	GABRG2 ABCA5 PTPRM GRIA1 GRM5	5.99e-05	194	95	5	b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2-10\|World / Primary Cells by Cluster	GABRG2 ABCA5 PTPRM GRIA1 GRM5	5.99e-05	194	95	5	81e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	DYNC2H1 RGS22 DYNC2I1 SAXO2 CFAP44	5.99e-05	194	95	5	b4ce60c06568123008b1081d644733cb91c28f51
ToppCell	NS-critical-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	WDR93 DYNC2H1 RGS22 SAXO2 CFAP44	5.99e-05	194	95	5	1ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	DYNC2H1 RGS22 DYNC2I1 SAXO2 CFAP44	5.99e-05	194	95	5	7a7ddccfe72a4a0dc4d1a5c809988f0069f9f1a3
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC4 IQCA1 DNAH17 GCM1 GRM5	5.99e-05	194	95	5	8ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DYNC2H1 RGS22 DYNC2I1 SAXO2 CFAP44	5.99e-05	194	95	5	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	facs-Aorta-Heart-3m-Endothelial-aorta_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBR2 SLK ENTPD1 HSD3B1 ARAP2	6.14e-05	195	95	5	3969b8d5fcec8ef1831531a781f7bbcebab5a4ba
ToppCell	COVID-19-Epithelial-Ciliated_cells\|Epithelial / Condition, Lineage and Cell class	IQCA1 DYNC2H1 DYNC2I1 SAXO2 CFAP44	6.29e-05	196	95	5	de7aa31354b019d7321a8ef965d59ce2e8b89276
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG2 ABCA5 PAK5 GRIA1 GRM5	6.29e-05	196	95	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	critical-Epithelial-Ciliated\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	IQCA1 DYNC2H1 RGS22 SAXO2 CFAP44	6.29e-05	196	95	5	27b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell	(7)_MNP-(7)_Macrophage\|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)	PEBP1 IGHM GATM FUCA1 ADI1	6.29e-05	196	95	5	71ec157163278ad259c190051926bf41e4ecef46
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PHPT1 PEBP1 GATM UQCRB ADI1	6.29e-05	196	95	5	3cf73ed99f3efa76b632c16a8b98b6b7758ff63f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PEBP1 GATM RPS19 UQCRB ADI1	6.44e-05	197	95	5	291458becbf90e9dda22ea069df7f9a45d827bcd
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG2 ABCA5 PAK5 GRIA1 GRM5	6.60e-05	198	95	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG2 ABCA5 PAK5 GRIA1 GRM5	6.60e-05	198	95	5	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG2 ABCA5 PAK5 GRIA1 GRM5	6.60e-05	198	95	5	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG2 ABCA5 PAK5 GRIA1 GRM5	6.60e-05	198	95	5	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	PEBP1 GATM FXYD4 RPS19 UQCRB	6.75e-05	199	95	5	f38e7bc3dc0e7822bee2df5634bf47a5c7145d60
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	GABRG2 ABCA5 PAK5 GRIA1 GRM5	6.92e-05	200	95	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Airway\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BMP3 HHLA1 MYRF EPHA1	1.19e-04	118	95	4	8d96a4879b28979fa04fbaeffa271a6b9ecbe867
ToppCell	Sigmoid-Dendritic_cell-cDC2\|Dendritic_cell / Region, Cell class and subclass	SYNRG ENTPD1 RPS19	1.21e-04	45	95	3	5488dced1d338166f3021509ebe8673e03995978
Disease	mismatch repair cancer syndrome (is_implicated_in)	TGFBR2 TAF1B MSH2	6.12e-06	12	91	3	DOID:0112182 (is_implicated_in)
Disease	cyclic adenosine monophosphate measurement	ABCC4 PTPRM ARAP2	1.87e-05	17	91	3	EFO_0010473
Disease	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy	SETX TDP1	2.82e-05	3	91	2	cv:C1846574
Disease	Cocaine Abuse	GABRG2 HTR1B GRIA1 GRM5 CHRNA4	4.72e-05	127	91	5	C0009171
Disease	Lynch syndrome (is_implicated_in)	TGFBR2 TAF1B MSH2	5.48e-05	24	91	3	DOID:3883 (is_implicated_in)
Disease	Short rib-polydactyly syndrome, Verma-Naumoff type	DYNC2H1 DYNC2I1	9.35e-05	5	91	2	C0432197
Disease	X-12244--N-acetylcarnosine measurement	TGFBR2 ABCC4	1.96e-04	7	91	2	EFO_0021299
Disease	age of onset of anorexia nervosa	CMAHP DCBLD2	1.96e-04	7	91	2	OBA_2050099
Disease	blood N-acetylcarnosine measurement	TGFBR2 ABCC4	1.96e-04	7	91	2	EFO_0022217
Disease	N-acetylcarnosine measurement	TGFBR2 ABCC4	2.60e-04	8	91	2	EFO_0022101
Disease	Lynch Syndrome	TGFBR2 MSH2	3.34e-04	9	91	2	C4552100
Disease	hyperprolactinemia (biomarker_via_orthology)	HSD3B1 HSD3B2	3.34e-04	9	91	2	DOID:12700 (biomarker_via_orthology)
Disease	carbohydrate measurement	EYS PTPRM GRIA1	3.91e-04	46	91	3	EFO_0004998
Disease	membranoproliferative glomerulonephritis (implicated_via_orthology)	TGFBR2 F5	4.17e-04	10	91	2	DOID:2920 (implicated_via_orthology)
Disease	Cocaine-Related Disorders	GABRG2 HTR1B GRIA1 GRM5	4.81e-04	117	91	4	C0236736
Disease	Jeune thoracic dystrophy	DYNC2H1 DYNC2I1	5.08e-04	11	91	2	C0265275
Disease	Short Rib-Polydactyly Syndrome	DYNC2H1 DYNC2I1	7.18e-04	13	91	2	C0036996
Disease	respiratory quotient	CAMK1D UNC13A	8.36e-04	14	91	2	EFO_0005189
Disease	Saldino-Noonan Syndrome	DYNC2H1 DYNC2I1	8.36e-04	14	91	2	C0036069
Disease	Majewski Syndrome	DYNC2H1 DYNC2I1	8.36e-04	14	91	2	C0024507
Disease	Cocaine Dependence	GABRG2 HTR1B GRIA1 GRM5	9.18e-04	139	91	4	C0600427
Disease	hepatic encephalopathy (biomarker_via_orthology)	GABRG2 GRIA1	9.62e-04	15	91	2	DOID:13413 (biomarker_via_orthology)
Disease	Sclerocystic Ovaries	HSD3B1 HSD3B2 RP2 DCBLD2	1.05e-03	144	91	4	C1136382
Disease	Polycystic Ovary Syndrome	HSD3B1 HSD3B2 RP2 DCBLD2	1.05e-03	144	91	4	C0032460
Disease	Autistic Disorder	HTR1B NSD1 GRIA1 MBD4 CHRNA4	1.30e-03	261	91	5	C0004352
Disease	pentachlorophenol measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022071
Disease	parathion measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022070
Disease	potassium chromate measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022072
Disease	mercuric chloride measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022068
Disease	heptachlor epoxide measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022067
Disease	methoxychlor measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022069
Disease	4,6-dinitro-o-cresol measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022053
Disease	2,4,5-trichlorophenol measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022052
Disease	azinphos methyl measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022055
Disease	aldrin measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022054
Disease	dicofol measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022060
Disease	disulfoton measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022062
Disease	dieldrin measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022061
Disease	endrin measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022064
Disease	endosulfan measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022063
Disease	heptachlor measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022066
Disease	ethion measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022065
Disease	chlorpyrifos measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022057
Disease	cadmium chloride measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022056
Disease	diazinon measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022059
Disease	dibutyl phthalate measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0022058
Disease	environmental exposure measurement	EYS F5 TNS1	1.51e-03	73	91	3	EFO_0008360
Disease	DDT metabolite measurement	EYS F5 TNS1	1.57e-03	74	91	3	EFO_0007886
Disease	psoriasis, type 2 diabetes mellitus	IL12B FAP IFNLR1	1.63e-03	75	91	3	EFO_0000676, MONDO_0005148
Disease	Colorectal Neoplasms	ABCC4 CACUL1 ABCA5 MSH2 EPHA1	1.69e-03	277	91	5	C0009404
Disease	coagulation factor V measurement	PAK5 F5	1.72e-03	20	91	2	EFO_0008087
Disease	serum homoarginine measurement	GATM TNS1	1.72e-03	20	91	2	EFO_0005421
Disease	total iron binding capacity	CMAHP F5 MYRF	1.83e-03	78	91	3	EFO_0006334
Disease	kidney disease (biomarker_via_orthology)	TGFBR2 GATM	1.90e-03	21	91	2	DOID:557 (biomarker_via_orthology)
Disease	Attention Deficit Disorder	GRM5 CHRNA4	2.09e-03	22	91	2	C0041671
Disease	Minimal Brain Dysfunction	GRM5 CHRNA4	2.09e-03	22	91	2	C1321905
Disease	Attention deficit hyperactivity disorder	GRM5 CHRNA4	2.48e-03	24	91	2	C1263846
Disease	psoriatic arthritis	IL12B FAP TNS1	2.49e-03	87	91	3	EFO_0003778
Disease	pulmonary embolism	ABCC4 DNAH17	2.69e-03	25	91	2	EFO_0003827
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	TGFBR2 MSH2	2.91e-03	26	91	2	C0009405

Protein segments in the cluster

Peptide	Gene	Start	Entry
KWLYNEYVTELPAFK	UNC13A	1121	Q9UPW8
KPSYWSKSKRNYEEL	ABCA5	436	Q8WWZ7
EDKLWLKPYVDLQAY	EPHA1	591	P21709
YKLRWDPADYENVTS	CHRNA4	96	P43681
KDYIYQDSISLPWKV	HTR1B	36	P28222
DLAYKPLYSWEEAKQ	HSD3B2	336	P26439
ELPGAEYQYKKDEVW	BMP3	301	P12645
QEYSDWKEKKTYLNP	CHEK1	216	O14757
RDLAYKPLYSWEEAK	HSD3B1	336	P14060
LTKELYPYWISALDT	ARAP2	1201	Q8WZ64
YPYWISALDTQDDKE	ARAP2	1206	Q8WZ64
KEWEELYKSKPGDDY	CFAP44	1141	Q96MT7
PVYKEEEESFKNWYA	IQCA1	781	Q86XH1
YIRKAEYPFSSEQKW	ATP2C1	446	P98194
DYKSTYWPKLDGAID	CACUL1	131	Q86Y37
KPSKWLLEYTEEYDQ	NSD1	1276	Q96L73
LPKEQWTKYEEENFY	UQCRB	76	P14927
SKEYLSENEPWVDKY	RAD17	81	O75943
WKKEFIYYADVKEPE	RAB9A	101	P51151
WQKEFIYYADVKDPE	RAB9B	101	Q9NP90
KEGTPEEKTYYIELW	RABL3	51	Q5HYI8
KYIEEFNKSWDYTPN	MTCL1	1426	Q9Y4B5
KVPSENKDLYEYSWV	NCSTN	591	Q92542
DEDISEKIKEPLYYW	NUDCD1	266	Q96RS6
EKIKEPLYYWQQTED	NUDCD1	271	Q96RS6
LDQSAPKLSKRYYWE	OVOS1	946	Q6IE37
LSKPSEYSDLKWEYQ	PAK5	206	Q9P286
AKPEYISKTYKIDSW	GNL2	401	Q13823
SPDVKWFDDYYLKLR	GRM5	331	P41594
DWPYFTDYMTSLKKE	EYS	1816	Q5T1H1
DKYSDLRYDPNWKSK	JHY	121	Q6NUN7
SSKSPWVESEYLDYL	IFNLR1	106	Q8IU57
FTIEVKANTYEKYWP	GATM	91	P50440
DTNLVYPALKWDLEY	HIF1AN	66	Q9NWT6
IEYPDSWYRDITSNK	NAA60	36	Q9H7X0
ELFENKPYTATVDYW	CHUK	191	O15111
KLQYGDSKDNPLKYW	DYNC2I1	191	Q8WVS4
DSKDNPLKYWLYKEE	DYNC2I1	196	Q8WVS4
WVFKDSVSYDYEPQK	ISM2	316	Q6H9L7
LFLSYDYAVKKPWLA	PCYOX1	421	Q9UHG3
RKDTEYKEEPLWYTE	KIAA0232	391	Q92628
AEWDDYVPKLYEQLS	PEBP1	171	P30086
ELFSNKPYNYKSDVW	NEK4	176	P51957
YDLVNSYKPDLIWSD	FUCA1	216	P04066
EPKQELKVWYAASYA	PRDM10	316	Q9NQV6
SLYIYKWPAEKENDT	ENTPD1	61	P49961
LKKDVYVVELDWYPD	IL12B	26	P29460
LIYWDDDKRYSPSLK	IGHV2-5	71	P01817
YTDLEKEAPWEYQKR	ABCC4	1016	O15439
NLWEDPYYLVKESLK	DYNC2H1	271	Q8NCM8
YTEPLWKAAVSQYEK	DYNC2H1	376	Q8NCM8
DTRYEPYIKWEDKDA	ETV7	236	Q9Y603
QDFLPDSITFSWKYK	IGHM	31	P01871
DYYIDPDTKKFLPWT	DNAH17	2396	Q9UFH2
WPDSYAKHIYSSEDK	GCM1	36	Q9NP62
YEDYASNKTWVLTPK	GABRG2	46	P18507
DEYLTKQWKYPIELH	MBD4	521	O95243
KTTLYDMDVEPSWKY	MAPKBP1	616	O60336
NRKKKTEGTYDLPYW	DCBLD2	556	Q96PD2
VDWKRPKYTSALTYD	GRIA1	281	P42261
ASKENDWYLAYKASP	MSH2	111	P43246
YWPDDTEIYKDIKVT	PTPRM	1011	P28827
KDDPFYYDWKNLQLS	FXYD4	26	P59646
SDFWEIEEKYPIINY	HHLA1	201	C9JL84
FYKSSTQKAYEDVPW	SPATA48	236	A4D263
KHKELAPYDENWFYT	RPS19	41	P39019
TSKDRPYDYKADVWS	SLK	206	Q9H2G2
PWIYNESLVPDAYKK	SYNRG	291	Q9UMZ2
YTYKWNILEFDEPTE	F5	481	P12259
QKWELNTYLYAPKDD	OGA	86	O60502
TVRWDYQPDICKDYK	RNF113B	186	Q8IZP6
PTWCYSKYIEALEQE	RGS22	1206	Q8NE09
LWKSEKPLYYSFVDK	TAF1B	426	Q53T94
EYKFPKNVNWEYKTD	PPWD1	256	Q96BP3
YPKTKKYLVTEWLND	SETD5	696	Q9C0A6
VYNYNPEKTKKDSGW	SETX	356	Q7Z333
VKIFPYEEYASWKTE	TGFBR2	276	P37173
TEKIKAKYPDYEVTW	PHPT1	106	Q9NRX4
EQILKAEYEFDSPYW	CAMK1D	231	Q8IU85
ALSTAKYKNWPESVY	PRG4	1246	Q92954
YKDSWDFEPYLEILN	CMAHP	326	Q9Y471
GIYYETWNVKASPEK	CLN5	206	O75503
IPDWVYEEEMLATKY	FAP	196	Q12884
YLMAYNAPSLKEWID	TDP1	326	Q9NUW8
LWLKTLSPENYAAYK	UBTFL1	286	P0CB47
SKEVIKPYDWTYTTD	TIPRL	101	O75663
DTPYDYKADIWSLGI	STK10	211	O94804
VQDTSKYWYKPEISR	TNS1	1456	Q9HBL0
QYSWDQREKVDPKDY	RP2	26	O75695
TILLEAAKEWPDVYY	THUMPD2	311	Q9BTF0
TSDADPMWYLKYLNI	POLR3B	66	Q9NW08
KLDTVPTYKDDYRAW	SAXO2	76	Q658L1
LHSKPEDTDTWLKYY	ZNF84	166	P51523
SYKKYLDREWEEEPL	WDR93	336	Q6P2C0
PEKDIYEIYSFQWDI	ZFP14	91	Q9HCL3
LQLVKPWYDEVKDYA	PI15	136	O43692
ANAWENLLYKKEPEY	TIGD7	396	Q6NT04
WDTDVEYKKKQDPYL	TBL2	306	Q9Y4P3
LLDYVERYDPKTDTW	KLHL1	666	Q9NR64
VLYWKLDADKYENDP	ADI1	36	Q9BV57
WATLYDANYKELPML	MYRF	361	Q9Y2G1