Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF597 ZNF384 ZNF17 ZNF777 ZNF24 ZNF117 GZF1 ZNF394 ZNF33A FOXO6 ZFP3 ZNF544 ZNF792 MZF1 ZFP30 ZNF197 ZNF189 ZNF534 MECOM ZNF75D ZNF480 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF582 ZNF840P ZFP82 ZNF169 ZNF835 ZNF646	1.67e-20	1459	58	31	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF597 ZNF384 ZNF17 ZNF777 ZNF24 ZNF117 GZF1 ZNF394 ZNF33A FOXO6 ZFP3 ZNF544 ZNF792 MZF1 ZFP30 ZNF197 ZNF189 ZNF534 MECOM ZNF75D ZNF480 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF582 ZNF840P ZFP82 ZNF169 ZNF646	9.53e-20	1412	58	30	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF597 ZNF384 ZNF17 ZNF24 ZNF117 GZF1 ZNF394 ZNF33A FOXO6 ZFP3 ZNF544 ZNF792 MZF1 ZFP30 ZNF197 ZNF189 ZNF534 MECOM ZNF75D ZNF480 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF840P ZFP82 ZNF835 ZNF646	6.22e-19	1244	58	28	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF597 ZNF384 ZNF17 ZNF24 ZNF117 GZF1 ZNF394 ZNF33A FOXO6 ZFP3 ZNF544 ZNF792 MZF1 ZFP30 ZNF197 ZNF189 ZNF534 MECOM ZNF75D ZNF480 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF840P ZFP82 ZNF835 ZNF646	1.10e-18	1271	58	28	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF597 ZNF384 ZNF24 GZF1 ZNF33A ZNF544 MZF1 ZNF197 MECOM ZNF850 ZNF840P	5.28e-07	560	58	11	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF597 ZNF384 ZNF24 GZF1 ZNF33A ZNF544 MZF1 ZNF197 MECOM ZNF850 ZNF840P	5.86e-07	566	58	11	GO:0001216
GeneOntologyMolecularFunction	superoxide-generating NADPH oxidase activator activity	NCF1C NCF1B	3.68e-04	10	58	2	GO:0016176
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	NCF1C NCF1B	5.37e-04	12	58	2	GO:0016175
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	NCF1C NCF1B	1.52e-03	20	58	2	GO:0050664
GeneOntologyBiologicalProcess	neutrophil-mediated killing of gram-positive bacterium	NCF1C NCF1B	7.73e-05	5	58	2	GO:0070946
GeneOntologyBiologicalProcess	NADP catabolic process	NCF1C NCF1B	1.62e-04	7	58	2	GO:0006742
GeneOntologyBiologicalProcess	neutrophil-mediated killing of fungus	NCF1C NCF1B	1.62e-04	7	58	2	GO:0070947
MousePheno	increased angiotensin I-converting enzyme activity	NCF1C NCF1B	7.10e-05	6	31	2	MP:0003184
MousePheno	abnormal angiotensin I-converting enzyme activity	NCF1C NCF1B	7.10e-05	6	31	2	MP:0013254
MousePheno	liver abscess	NCF1C NCF1B	9.93e-05	7	31	2	MP:0003332
Domain	-	ZNF597 ZNF384 ZNF17 ZNF777 ZNF24 ZNF117 GZF1 ZNF394 ZNF33A ZFP3 ZNF544 ZNF792 MZF1 ZFP30 ZNF197 ZNF189 ZNF534 MECOM ZNF75D ZNF480 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF582 ZFP82 ZNF169 ZNF835 ZNF646	1.47e-27	679	55	29	3.30.160.60
Domain	zf-C2H2	ZNF597 ZNF384 ZNF17 ZNF777 ZNF24 ZNF117 GZF1 ZNF394 ZNF33A ZFP3 ZNF544 ZNF792 MZF1 ZFP30 ZNF197 ZNF189 ZNF534 MECOM ZNF75D ZNF480 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF582 ZFP82 ZNF169 ZNF835 ZNF646	2.63e-27	693	55	29	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF597 ZNF384 ZNF17 ZNF777 ZNF24 ZNF117 GZF1 ZNF394 ZNF33A ZFP3 ZNF544 ZNF792 MZF1 ZFP30 ZNF197 ZNF189 ZNF534 MECOM ZNF75D ZNF480 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF582 ZFP82 ZNF169 ZNF835 ZNF646	2.75e-27	694	55	29	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF597 ZNF384 ZNF17 ZNF777 ZNF24 ZNF117 GZF1 ZNF394 ZNF33A ZFP3 ZNF544 ZNF792 MZF1 ZFP30 ZNF197 ZNF189 ZNF534 MECOM ZNF75D ZNF480 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF582 ZFP82 ZNF169 ZNF835 ZNF646	6.41e-26	775	55	29	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF597 ZNF384 ZNF17 ZNF777 ZNF24 ZNF117 GZF1 ZNF394 ZNF33A ZFP3 ZNF544 ZNF792 MZF1 ZFP30 ZNF197 ZNF189 ZNF534 MECOM ZNF75D ZNF480 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF582 ZFP82 ZNF169 ZNF835 ZNF646	6.90e-26	777	55	29	PS00028
Domain	Znf_C2H2-like	ZNF597 ZNF384 ZNF17 ZNF777 ZNF24 ZNF117 GZF1 ZNF394 ZNF33A ZFP3 ZNF544 ZNF792 MZF1 ZFP30 ZNF197 ZNF189 ZNF534 MECOM ZNF75D ZNF480 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF582 ZFP82 ZNF169 ZNF835 ZNF646	1.37e-25	796	55	29	IPR015880
Domain	Znf_C2H2	ZNF597 ZNF384 ZNF17 ZNF777 ZNF24 ZNF117 GZF1 ZNF394 ZNF33A ZFP3 ZNF544 ZNF792 MZF1 ZFP30 ZNF197 ZNF189 ZNF534 MECOM ZNF75D ZNF480 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF582 ZFP82 ZNF169 ZNF835 ZNF646	1.89e-25	805	55	29	IPR007087
Domain	ZnF_C2H2	ZNF597 ZNF384 ZNF17 ZNF777 ZNF24 ZNF117 GZF1 ZNF394 ZNF33A ZFP3 ZNF544 ZNF792 MZF1 ZFP30 ZNF197 ZNF189 ZNF534 MECOM ZNF75D ZNF480 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF582 ZFP82 ZNF169 ZNF835 ZNF646	2.10e-25	808	55	29	SM00355
Domain	KRAB	ZNF597 ZNF17 ZNF777 ZNF394 ZNF33A ZNF544 ZNF792 ZFP30 ZNF197 ZNF189 ZNF534 ZNF75D ZNF480 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF582 ZFP82 ZNF169	1.32e-20	369	55	20	SM00349
Domain	KRAB	ZNF597 ZNF17 ZNF777 ZNF394 ZNF33A ZNF544 ZNF792 ZFP30 ZNF197 ZNF189 ZNF534 ZNF75D ZNF480 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF582 ZFP82 ZNF169	1.39e-20	370	55	20	IPR001909
Domain	KRAB	ZNF597 ZNF17 ZNF777 ZNF394 ZNF33A ZNF544 ZNF792 ZFP30 ZNF197 ZNF189 ZNF534 ZNF75D ZNF480 ZFP14 ZNF850 ZKSCAN5 ZNF582 ZFP82 ZNF169	2.18e-19	358	55	19	PS50805
Domain	KRAB	ZNF597 ZNF17 ZNF777 ZNF394 ZNF33A ZNF544 ZNF792 ZFP30 ZNF197 ZNF189 ZNF534 ZNF75D ZNF480 ZFP14 ZNF850 ZKSCAN5 ZNF582 ZFP82 ZNF169	2.18e-19	358	55	19	PF01352
Domain	zf-C2H2_6	ZNF597 ZNF384 ZNF17 ZNF24 ZNF117 GZF1 ZNF792 ZFP30 ZNF197 MECOM ZNF480 ZFP14 ZNF850 ZKSCAN5 ZNF582 ZFP82 ZNF169 ZNF646	5.81e-19	314	55	18	PF13912
Domain	SCAN	ZNF24 ZNF394 MZF1 ZNF197 ZNF75D ZSCAN25 ZKSCAN5	2.68e-10	56	55	7	SM00431
Domain	SCAN_BOX	ZNF24 ZNF394 MZF1 ZNF197 ZNF75D ZSCAN25 ZKSCAN5	3.46e-10	58	55	7	PS50804
Domain	SCAN	ZNF24 ZNF394 MZF1 ZNF197 ZNF75D ZSCAN25 ZKSCAN5	3.46e-10	58	55	7	PF02023
Domain	SCAN_dom	ZNF24 ZNF394 MZF1 ZNF197 ZNF75D ZSCAN25 ZKSCAN5	3.46e-10	58	55	7	IPR003309
Domain	Retrov_capsid_C	ZNF24 ZNF394 MZF1 ZNF197 ZNF75D ZSCAN25 ZKSCAN5	3.92e-10	59	55	7	IPR008916
Domain	Gonadal	DGCR6 DGCR6L	8.51e-06	2	55	2	IPR010849
Domain	DGCR6	DGCR6 DGCR6L	8.51e-06	2	55	2	PF07324
Domain	BROMODOMAIN_1	BRD9 BRWD3	5.31e-03	37	55	2	PS00633
Domain	Bromodomain	BRD9 BRWD3	5.59e-03	38	55	2	PF00439
Domain	BROMODOMAIN_2	BRD9 BRWD3	6.49e-03	41	55	2	PS50014
Domain	BROMO	BRD9 BRWD3	6.80e-03	42	55	2	SM00297
Domain	Bromodomain	BRD9 BRWD3	6.80e-03	42	55	2	IPR001487
Domain	-	BRD9 BRWD3	6.80e-03	42	55	2	1.20.920.10
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF597 ZNF17 ZNF777 ZNF394 ZNF33A FOXO6 ZNF544 ZNF792 ZFP30 ZNF197 ZNF189 ZNF75D ZNF480 ZFP14 ZSCAN25 ZKSCAN5 ZNF582 ZNF169	3.30e-09	1387	38	18	M734
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF394 FOXO6 ZFP30 ZNF189 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF169	1.58e-04	768	38	9	MM14851
Pathway	REACTOME_CROSS_PRESENTATION_OF_PARTICULATE_EXOGENOUS_ANTIGENS_PHAGOSOMES	NCF1C NCF1B	2.52e-04	9	38	2	MM14524
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF17 ZNF33A ZNF792 ZNF197 ZNF480 ZFP82	5.91e-07	181	58	6	37372979
Pubmed	Zinc finger protein genes in the mouse genome.	ZFP3 ZFP30 MECOM	9.58e-07	12	58	3	1797234
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ARHGAP5 DGCR6 PTPRA MYCBP2 SIPA1L1 ZNF197 CEP290 ZNF189 CIPC TRIP11 ZKSCAN5 BRWD3	1.14e-06	1285	58	12	35914814
Pubmed	Biochemical characterisation of the proteins encoded by the DiGeorge critical region 6 (DGCR6) genes.	DGCR6 DGCR6L	2.73e-06	2	58	2	15821931
Pubmed	Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome.	DGCR6 DGCR6L	2.73e-06	2	58	2	22832905
Pubmed	A mouse gene (Dgcr6) related to the Drosophila gonadal gene is expressed in early embryogenesis and is the homolog of a human gene deleted in DiGeorge syndrome.	DGCR6 DGCR6L	2.73e-06	2	58	2	9605865
Pubmed	Functional pseudogenes inhibit the superoxide production.	NCF1C NCF1B	2.73e-06	2	58	2	26086043
Pubmed	Two functional copies of the DGCR6 gene are present on human chromosome 22q11 due to a duplication of an ancestral locus.	DGCR6 DGCR6L	2.73e-06	2	58	2	11157784
Pubmed	The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues.	NCF1C NCF1B	8.19e-06	3	58	2	26645958
Pubmed	Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism.	NCF1C NCF1B	8.19e-06	3	58	2	33705493
Pubmed	Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation.	NCF1C NCF1B	8.19e-06	3	58	2	22050439
Pubmed	Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia.	NCF1C NCF1B	8.19e-06	3	58	2	18036262
Pubmed	Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis.	NCF1C NCF1B	8.19e-06	3	58	2	23965970
Pubmed	Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice.	NCF1C NCF1B	8.19e-06	3	58	2	10678931
Pubmed	The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.	NCF1C NCF1B	8.19e-06	3	58	2	12031896
Pubmed	Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.	NCF1C NCF1B	8.19e-06	3	58	2	12364355
Pubmed	Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome.	NCF1C NCF1B	8.19e-06	3	58	2	27044504
Pubmed	Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species.	NCF1C NCF1B	8.19e-06	3	58	2	17167081
Pubmed	Mice lacking NCF1 exhibit reduced growth of implanted melanoma and carcinoma tumors.	NCF1C NCF1B	8.19e-06	3	58	2	24358335
Pubmed	Molecular characterization of the mouse p47-phox (Ncf1) gene and comparative analysis of the mouse p47-phox (Ncf1) gene to the human NCF1 gene.	NCF1C NCF1B	8.19e-06	3	58	2	10891396
Pubmed	NAD(P)H oxidase-derived superoxide mediates hypercholesterolemia-induced leukocyte-endothelial cell adhesion.	NCF1C NCF1B	8.19e-06	3	58	2	11249873
Pubmed	P47phox-/- mice are compromised in expansion and activation of CD8+ T cells and susceptible to Trypanosoma cruzi infection.	NCF1C NCF1B	8.19e-06	3	58	2	25474113
Pubmed	Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice.	NCF1C NCF1B	8.19e-06	3	58	2	15936744
Pubmed	NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury.	NCF1C NCF1B	8.19e-06	3	58	2	18787174
Pubmed	NADPH oxidase modulates myocardial Akt, ERK1/2 activation, and angiogenesis after hypoxia-reoxygenation.	NCF1C NCF1B	8.19e-06	3	58	2	17220182
Pubmed	NAD(P)H oxidase subunit p47phox is elevated, and p47phox knockout prevents diaphragm contractile dysfunction in heart failure.	NCF1C NCF1B	8.19e-06	3	58	2	26209274
Pubmed	Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.	NCF1C NCF1B	8.19e-06	3	58	2	24873968
Pubmed	NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis.	NCF1C NCF1B	8.19e-06	3	58	2	24549323
Pubmed	NADPH oxidase p47phox siRNA attenuates adventitial fibroblasts proliferation and migration in apoE(-/-) mouse.	NCF1C NCF1B	8.19e-06	3	58	2	25628043
Pubmed	NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities.	NCF1C NCF1B	8.19e-06	3	58	2	34557202
Pubmed	Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.	NCF1C NCF1B	8.19e-06	3	58	2	28467721
Pubmed	P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+.	NCF1C NCF1B	8.19e-06	3	58	2	10670582
Pubmed	p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice.	NCF1C NCF1B	8.19e-06	3	58	2	22184329
Pubmed	Macrophage-derived reactive oxygen species protects against autoimmune priming with a defined polymeric adjuvant.	NCF1C NCF1B	8.19e-06	3	58	2	26455429
Pubmed	NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.	NCF1C NCF1B	8.19e-06	3	58	2	20881184
Pubmed	Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice.	NCF1C NCF1B	8.19e-06	3	58	2	15513930
Pubmed	NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.	NCF1C NCF1B	8.19e-06	3	58	2	11018074
Pubmed	Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection.	NCF1C NCF1B	8.19e-06	3	58	2	15626477
Pubmed	Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt.	NCF1C NCF1B	8.19e-06	3	58	2	15033459
Pubmed	The p47phox mouse knock-out model of chronic granulomatous disease.	NCF1C NCF1B	8.19e-06	3	58	2	7650482
Pubmed	Natural Loss-of-Function Mutations in Qa2 and NCF1 Cause the Spread of Mannan-Induced Psoriasis.	NCF1C NCF1B	8.19e-06	3	58	2	33545139
Pubmed	Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.	NCF1C NCF1B	8.19e-06	3	58	2	20142487
Pubmed	Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.	NCF1C NCF1B	8.19e-06	3	58	2	26528554
Pubmed	The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis.	NCF1C NCF1B	8.19e-06	3	58	2	19052348
Pubmed	Disseminated trichosporonosis in a murine model of chronic granulomatous disease.	NCF1C NCF1B	8.19e-06	3	58	2	12868577
Pubmed	Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit.	NCF1C NCF1B	8.19e-06	3	58	2	12560337
Pubmed	Effect of early particulate air pollution exposure on obesity in mice: role of p47phox.	NCF1C NCF1B	8.19e-06	3	58	2	20864666
Pubmed	Enhanced host defense after gene transfer in the murine p47phox-deficient model of chronic granulomatous disease.	NCF1C NCF1B	8.19e-06	3	58	2	9116268
Pubmed	Mice producing less reactive oxygen species are relatively resistant to collagen glycopeptide vaccination against arthritis.	NCF1C NCF1B	8.19e-06	3	58	2	20686129
Pubmed	NADPH oxidase mediates striatal neuronal injury after transient global cerebral ischemia.	NCF1C NCF1B	8.19e-06	3	58	2	20859296
Pubmed	Reactive oxygen species delay control of lymphocytic choriomeningitis virus.	NCF1C NCF1B	8.19e-06	3	58	2	23328631
Pubmed	Inhibition of endothelial Nox2 activation by LMH001 protects mice from angiotensin II-induced vascular oxidative stress, hypertension and aortic aneurysm.	NCF1C NCF1B	8.19e-06	3	58	2	35276443
Pubmed	p47phox-dependent NADPH oxidase regulates flow-induced vascular remodeling.	NCF1C NCF1B	8.19e-06	3	58	2	16109921
Pubmed	NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity.	NCF1C NCF1B	8.19e-06	3	58	2	19077231
Pubmed	ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia.	ZNF384 ZNF394	8.19e-06	3	58	2	35247902
Pubmed	Reactive oxygen species modulate growth of cerebral aneurysms: a study using the free radical scavenger edaravone and p47phox(-/-) mice.	NCF1C NCF1B	8.19e-06	3	58	2	19381132
Pubmed	p47phox-Dependent Oxidant Signalling through ASK1, MKK3/6 and MAPKs in Angiotensin II-Induced Cardiac Hypertrophy and Apoptosis.	NCF1C NCF1B	8.19e-06	3	58	2	34572995
Pubmed	Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles.	NCF1C NCF1B	8.19e-06	3	58	2	20828610
Pubmed	p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation.	NCF1C NCF1B	8.19e-06	3	58	2	20817944
Pubmed	Angiotensin II induced catabolic effect and muscle atrophy are redox dependent.	NCF1C NCF1B	8.19e-06	3	58	2	21570954
Pubmed	Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice.	NCF1C NCF1B	8.19e-06	3	58	2	17114280
Pubmed	p47(phox) contributes to albuminuria and kidney fibrosis in mice.	NCF1C NCF1B	8.19e-06	3	58	2	25565313
Pubmed	Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.	NCF1C NCF1B	8.19e-06	3	58	2	22319452
Pubmed	Genetics of autoimmune diseases: a multistep process.	NCF1C NCF1B	8.19e-06	3	58	2	16724810
Pubmed	Early determinants of H2O2-induced endothelial dysfunction.	NCF1C NCF1B	8.19e-06	3	58	2	16895801
Pubmed	Neutrophils augment LPS-mediated pro-inflammatory signaling in human lung epithelial cells.	NCF1C NCF1B	8.19e-06	3	58	2	22575681
Pubmed	Identification of a novel NCF-1 (p47-phox) pseudogene not containing the signature GT deletion: significance for A47 degrees chronic granulomatous disease carrier detection.	NCF1C NCF1B	8.19e-06	3	58	2	12176908
Pubmed	Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis.	NCF1C NCF1B	8.19e-06	3	58	2	20690191
Pubmed	Endosomal acidification and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis.	NCF1C NCF1B	8.19e-06	3	58	2	16772302
Pubmed	Knockout of neutrophil cytosolic factor 1 ameliorates neuroinflammation and motor deficit after traumatic brain injury.	NCF1C NCF1B	8.19e-06	3	58	2	39357591
Pubmed	Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice.	NCF1C NCF1B	8.19e-06	3	58	2	32504071
Pubmed	Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury.	NCF1C NCF1B	8.19e-06	3	58	2	19168575
Pubmed	Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells.	NCF1C NCF1B	8.19e-06	3	58	2	16280459
Pubmed	Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.	NCF1C NCF1B	8.19e-06	3	58	2	18185592
Pubmed	Loss of NADPH oxidase-derived superoxide skews macrophage phenotypes to delay type 1 diabetes.	NCF1C NCF1B	8.19e-06	3	58	2	25288672
Pubmed	Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion.	NCF1C NCF1B	8.19e-06	3	58	2	12958309
Pubmed	Lack of reactive oxygen species breaks T cell tolerance to collagen type II and allows development of arthritis in mice.	NCF1C NCF1B	8.19e-06	3	58	2	17641008
Pubmed	Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells.	NCF1C NCF1B	8.19e-06	3	58	2	11435342
Pubmed	Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.	NCF1C NCF1B	8.19e-06	3	58	2	31118934
Pubmed	Female mice lacking p47phox have altered adipose tissue gene expression and are protected against high fat-induced obesity.	NCF1C NCF1B	8.19e-06	3	58	2	23482812
Pubmed	A p47-phox pseudogene carries the most common mutation causing p47-phox- deficient chronic granulomatous disease.	NCF1C NCF1B	8.19e-06	3	58	2	9329953
Pubmed	Hyperoxia impairs postnatal alveolar epithelial development via NADPH oxidase in newborn mice.	NCF1C NCF1B	8.19e-06	3	58	2	19411313
Pubmed	Dependence of liver injury after hemorrhage/resuscitation in mice on NADPH oxidase-derived superoxide.	NCF1C NCF1B	8.19e-06	3	58	2	12688546
Pubmed	NCF1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell development and functions.	NCF1C NCF1B	8.19e-06	3	58	2	36853827
Pubmed	Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation.	NCF1C NCF1B	8.19e-06	3	58	2	23024271
Pubmed	B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production.	NCF1C NCF1B	8.19e-06	3	58	2	25989352
Pubmed	Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.	NCF1C NCF1B	8.19e-06	3	58	2	16041040
Pubmed	Superoxide prevents nitric oxide-mediated suppression of helper T lymphocytes: decreased autoimmune encephalomyelitis in nicotinamide adenine dinucleotide phosphate oxidase knockout mice.	NCF1C NCF1B	8.19e-06	3	58	2	10799876
Pubmed	The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs.	NCF1C NCF1B	8.19e-06	3	58	2	10085000
Pubmed	Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators.	NCF1C NCF1B	8.19e-06	3	58	2	10987289
Pubmed	Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells.	NCF1C NCF1B	8.19e-06	3	58	2	21253614
Pubmed	NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.	NCF1C NCF1B	8.19e-06	3	58	2	19503084
Pubmed	Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae.	NCF1C NCF1B	8.19e-06	3	58	2	21435178
Pubmed	Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2.	NCF1C NCF1B	8.19e-06	3	58	2	25873172
Pubmed	Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.	NCF1C NCF1B	8.19e-06	3	58	2	17404617
Pubmed	Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction.	NCF1C NCF1B	8.19e-06	3	58	2	17332431
Pubmed	Critical role for p47phox in renin-angiotensin system activation and blood pressure regulation.	NCF1C NCF1B	8.19e-06	3	58	2	16843452
Pubmed	Lpp of Escherichia coli K1 inhibits host ROS production to counteract neutrophil-mediated elimination.	NCF1C NCF1B	8.19e-06	3	58	2	36592568
Pubmed	Molecular insights of p47phox phosphorylation dynamics in the regulation of NADPH oxidase activation and superoxide production.	NCF1C NCF1B	8.19e-06	3	58	2	24970888
Pubmed	Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene.	NCF1C NCF1B	8.19e-06	3	58	2	15310853
Interaction	ZNF473 interactions	ZNF24 GZF1 ZFP3 ZNF792 MZF1	5.18e-07	56	57	5	int:ZNF473
Interaction	ZSCAN20 interactions	ZNF24 ZNF394 ZNF197 ZSCAN25 ZKSCAN5	1.10e-06	65	57	5	int:ZSCAN20
Interaction	ZNF513 interactions	ZNF24 GZF1 ZFP3 MZF1	2.50e-06	34	57	4	int:ZNF513
Interaction	ZBTB47 interactions	ZNF777 GZF1 ZNF394 ZNF189 ZSCAN25 ZNF646	3.22e-06	144	57	6	int:ZBTB47
Interaction	ZSCAN1 interactions	ZNF24 MZF1 ZSCAN25 ZKSCAN5	1.76e-05	55	57	4	int:ZSCAN1
Interaction	CCDC140 interactions	ZNF384 NEPRO GZF1 ZNF189 ZSCAN25	1.99e-05	117	57	5	int:CCDC140
Interaction	YJU2B interactions	ZNF17 ZNF24 ZFP3 ZNF835	3.02e-05	63	57	4	int:YJU2B
Interaction	SCAND1 interactions	ZNF24 ZNF394 MZF1 ZSCAN25	4.59e-05	70	57	4	int:SCAND1
Interaction	ZSCAN10 interactions	ZNF24 GZF1 ZFP3	5.33e-05	26	57	3	int:ZSCAN10
Interaction	ZNF423 interactions	ZNF17 GZF1 ZFP3 CEP290	5.41e-05	73	57	4	int:ZNF423
Interaction	ZNF768 interactions	ZNF24 GZF1 ZFP3 MZF1 ZNF835	6.76e-05	151	57	5	int:ZNF768
Interaction	PGBD1 interactions	ZNF24 MYCBP2 ZSCAN25	7.44e-05	29	57	3	int:PGBD1
Interaction	RBAK interactions	ZNF777 ZNF24 ZFP3 ZNF169	8.14e-05	81	57	4	int:RBAK
Interaction	ZFP3 interactions	ZNF24 GZF1 ZFP3	8.25e-05	30	57	3	int:ZFP3
Interaction	LTBP2 interactions	ZNF17 ZNF777 ZNF480 ZNF646	9.82e-05	85	57	4	int:LTBP2
Interaction	ZNF382 interactions	ZNF24 GZF1 ZFP3	1.10e-04	33	57	3	int:ZNF382
Interaction	ZNF652 interactions	ZNF24 GZF1 ZFP3	1.32e-04	35	57	3	int:ZNF652
Interaction	ZFP28 interactions	ZNF24 GZF1 ZFP3	1.56e-04	37	57	3	int:ZFP28
Interaction	NOTCH2 interactions	ZNF777 PTPRA ZNF189 ZNF480 ZSCAN25 ZC3H3 ZNF646	1.83e-04	423	57	7	int:NOTCH2
Interaction	GZF1 interactions	ZNF24 GZF1 ZFP3 ZNF169	2.06e-04	103	57	4	int:GZF1
Interaction	ZSCAN32 interactions	ZNF24 ZNF394 ZNF197	2.80e-04	45	57	3	int:ZSCAN32
Interaction	ZFP37 interactions	ZNF24 GZF1 ZFP3	3.60e-04	49	57	3	int:ZFP37
Interaction	OASL interactions	ZNF777 GZF1 ZNF189 ZSCAN25 ZNF646	4.16e-04	223	57	5	int:OASL
Interaction	CENPB interactions	ZNF17 ZNF544 ASPM ZNF169	4.19e-04	124	57	4	int:CENPB
Interaction	PRDM4 interactions	ZNF24 GZF1 ZFP3	4.30e-04	52	57	3	int:PRDM4
Interaction	ZNF232 interactions	ZNF24 ZNF197 ZKSCAN5	4.30e-04	52	57	3	int:ZNF232
Interaction	GLI4 interactions	ZNF777 GZF1 ZNF189 ZSCAN25	4.32e-04	125	57	4	int:GLI4
Interaction	ZNF668 interactions	NEPRO ZNF777 LLGL2 ZNF792 ZNF646	4.42e-04	226	57	5	int:ZNF668
Interaction	ZSCAN21 interactions	ZNF24 GZF1 ZFP3 ZKSCAN5	4.73e-04	128	57	4	int:ZSCAN21
Interaction	ZNF169 interactions	GZF1 ZSCAN25 ZNF169	4.80e-04	54	57	3	int:ZNF169
Interaction	CCNDBP1 interactions	ZNF394 ZNF480 ZNF169 ZNF835	6.11e-04	137	57	4	int:CCNDBP1
Interaction	ZNF483 interactions	ZNF24 ZNF197 ZSCAN25	6.23e-04	59	57	3	int:ZNF483
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF17 ZNF544 ZNF792 MZF1 ZFP30 ZNF534 ZNF480 ZFP14 ZNF850 ZNF582 ZFP82 ZNF835 NLRP8	2.44e-09	1192	58	13	chr19q13
Cytoband	19q13.12	ZFP30 ZFP14 ZNF850 ZFP82	2.21e-06	72	58	4	19q13.12
Cytoband	19q13.43	ZNF544 ZNF582 ZNF835 NLRP8	4.72e-06	87	58	4	19q13.43
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	ZNF394 ZSCAN25 ZKSCAN5	2.72e-03	219	58	3	chr7q22
Cytoband	19q13.41	ZNF534 ZNF480	4.43e-03	78	58	2	19q13.41
Cytoband	19q13.4	ZNF17 MZF1	4.54e-03	79	58	2	19q13.4
Cytoband	Ensembl 112 genes in cytogenetic band chr7q11	ZNF117 NCF1C NCF1B	4.94e-03	271	58	3	chr7q11
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF597 ZNF384 ZNF17 ZNF777 ZNF24 ZNF117 GZF1 ZNF394 ZNF33A ZFP3 ZNF544 ZNF792 MZF1 ZFP30 ZNF197 ZNF189 ZNF534 MECOM ZNF75D ZNF480 ZFP14 ZSCAN25 ZNF850 ZKSCAN5 ZNF582 ZFP82 ZNF169 ZNF835 ZNF646	1.76e-30	718	44	29	28
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP5 LLGL2 PKHD1 ZNF534 MECOM	3.16e-06	177	57	5	c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NEPRO ZNF117 GZF1 ASPM ZNF850	4.46e-06	190	57	5	3f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NEPRO ZNF117 GZF1 ASPM ZNF850	4.70e-06	192	57	5	c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCell	356C-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ZNF480 ZFP14 CIPC ZNF582	2.79e-05	136	57	4	edfd453c9a650d69d05a5a3ab15f7df56349fa86
ToppCell	356C-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ZNF480 ZFP14 CIPC ZNF582	2.79e-05	136	57	4	03e4e2353c23ceffde35b2d0aadd15299e3db09f
Drug	B202	DGCR6 DGCR6L	6.38e-06	2	58	2	CID006435965
Drug	Levocabastine hydrochloride [79547-78-7]; Down 200; 8.8uM; MCF7; HT_HG-U133A	ZNF384 PTPRA MZF1 SIPA1L1 CEP290 ZC3H3	1.15e-05	199	58	6	7009_DN
Disease	hormone measurement, testosterone measurement	ZNF394 ZKSCAN5	8.78e-06	3	51	2	EFO_0004730, EFO_0004908
Disease	chronic granulomatous disease (implicated_via_orthology)	NCF1C NCF1B	2.92e-05	5	51	2	DOID:3265 (implicated_via_orthology)
Disease	proline measurement, amino acid measurement	DGCR6 DGCR6L	2.92e-05	5	51	2	EFO_0005134, EFO_0009773
Disease	hormone measurement, progesterone measurement	ZNF394 ZKSCAN5	2.92e-05	5	51	2	EFO_0004730, EFO_0007004
Disease	hormone measurement, dehydroepiandrosterone sulphate measurement	ZNF394 ZKSCAN5	2.92e-05	5	51	2	EFO_0004730, EFO_0007001
Disease	peptidyl-glycine alpha-amidating monooxygenase measurement	LVRN MYCBP2	1.59e-04	11	51	2	EFO_0801871
Disease	rheumatoid arthritis (implicated_via_orthology)	NCF1C NCF1B	1.91e-04	12	51	2	DOID:7148 (implicated_via_orthology)
Disease	X-21410 measurement	ZNF394 ZKSCAN5	3.46e-04	16	51	2	EFO_0800813
Disease	metabolonic lactone sulfate measurement	ZNF394 ZSCAN25	4.92e-04	19	51	2	EFO_0800659
Disease	5alpha-androstan-3beta,17beta-diol disulfate measurement	ZNF394 ZKSCAN5	6.62e-04	22	51	2	EFO_0021115
Disease	proline measurement	DGCR6 DGCR6L	9.27e-04	26	51	2	EFO_0009773
Disease	cardiovascular age measurement	SIPA1L1 ZC3H3	1.15e-03	29	51	2	EFO_0803380
Disease	androsterone sulfate measurement	ZNF394 ZKSCAN5	1.49e-03	33	51	2	EFO_0021117
Disease	peptic ulcer disease	MECOM ZNF169	1.49e-03	33	51	2	MONDO_0004247
Disease	anthropometric measurement	MYCBP2 MECOM TRIP11	3.09e-03	168	51	3	EFO_0004302
Disease	joint damage measurement	KCNN2 MECOM	6.20e-03	68	51	2	EFO_0005413
Disease	dehydroepiandrosterone sulphate measurement	ZNF394 ZKSCAN5	6.20e-03	68	51	2	EFO_0007001
Disease	response to alcohol	SIPA1L1 PKHD1	7.50e-03	75	51	2	EFO_0005526
Disease	preeclampsia	MYCBP2 MECOM	8.09e-03	78	51	2	EFO_0000668

Protein segments in the cluster

Peptide	Gene	Start	Entry
DHSRTLFQLKQRRNV	BRD9	451	Q9H8M2
HQFRQHRTRVLSIRN	ADGB	1571	Q8N7X0
FTQLNALQRHRRIHT	GZF1	556	Q9H116
RKRQHTYQTRSNIEH	BRWD3	791	Q6RI45
RHRNLNHTKQRLLEV	ADAM33	226	Q9BZ11
HQRIRVHANLQTIKN	LVRN	956	Q6Q4G3
QNEHRVLRQALRQKH	DGCR6	86	Q14129
IIKFQAHVRKHQQRQ	ASPM	1586	Q8IZT6
LQRQHYLRQRHSAVI	ASPM	2376	Q8IZT6
ISSNLQRHVRNIHNK	MECOM	951	Q03112
HQQRRQVFVKCTLHP	LLGL2	616	Q6P1M3
RLKNFHVLSHVNIQR	NLRP8	526	Q86W28
HQRKFLQAIHQLRSV	KCNN2	451	Q9H2S1
IRHNLSLHTRFIRVQ	FOXO6	141	A8MYZ6
IRNVHSIHQRSRKRL	NCF1B	306	A6NI72
IRNAHSIHQRSRKRL	NCF1C	281	A8MVU1
KHLRQTIQSLRRQFS	CEP290	1261	O15078
QNEHRVLRQALRQKH	DGCR6L	86	Q9BY27
LKRATVQRAQHVFQH	BLMH	41	Q13867
ALRLHARHKEQQRQF	CCDC153	181	Q494R4
TRENKSRQIRQFHFH	PTPRA	681	P18433
TSKHHLRQRRSQNKF	NEPRO	436	Q6NW34
KNIRSHFQHVFVIVR	SIPA1L1	726	O43166
LHRRTKTHQRQVFKE	MYCBP2	4291	O75592
NNQNIHIHISSKRRE	PKHD1	3901	P08F94
RYVITHLNRVSQQHK	ARHGAP5	1386	Q13017
SQKRVVHLQLLRRHT	STARD9	741	Q9P2P6
QSKHRRFQNTLVVLH	CIPC	311	Q9C0C6
FSQRRSLVKHQRIHT	ZNF189	241	O75820
QKAFRQLSHLQQHTR	ZNF384	351	Q8TF68
AQCQLLHRTQKRHSR	ZC3H3	791	Q8IXZ2
FRHQRRHNAEKLLNV	ZNF24	351	P17028
VFRQRKNLTVHQKIH	ZNF197	966	O14709
QSTHLIRHQRIHQNK	ZNF394	536	Q53GI3
AFRVRQQLTFHQRIH	ZFP30	166	Q9Y2G7
RSILNRHQKTQHRQE	ZSCAN25	526	Q6NSZ9
RVNLTRHQKTHTQRK	ZNF840P	261	A6NDX5
RRRISFVQHQQQHQE	ZNF646	1771	O15015
KVFSRNSRLAQHRNI	ZNF534	626	Q76KX8
FRVSSQLKQHQRIHT	ZNF582	376	Q96NG8
TFSQKSNLIVHQRRH	ZNF33A	756	Q06730
KVFNQLSNLARHRRI	ZNF480	406	Q8WV37
KRFIQNSHLIKHQRT	ZNF75D	456	P51815
GKAFRVRQQLTFHHR	ZFP82	176	Q8N141
AFRVRQQLTLHQRIH	ZFP82	346	Q8N141
NAHQQKLTEISRRHR	TRIP11	241	Q15643
VRFAHRQAQLQRHRV	TEX13A	76	Q9BXU3
SFRQQSQLVVHRRTH	ZNF544	696	Q6NX49
KSTLVQHQRIHSRER	ZNF792	266	Q3KQV3
KAFTRVTHLTQHRRV	ZNF835	201	Q9Y2P0
LSHLTQHKRIQTRVN	ZNF117	121	Q03924
TFRLRQQLVRHQRIH	ZFP14	376	Q9HCL3
QQLVRHQRIHTREKP	ZFP14	381	Q9HCL3
KIFNHRANLRTHRRI	ZNF597	191	Q96LX8
ISFRHKQQLTLHQRI	ZNF777	581	Q9ULD5
FRLRLRLTQHQQIHT	ZNF850	626	A8MQ14
FRRRSKLTQHQRIHT	ZNF850	906	A8MQ14
RVFSQNSHLIRHQKV	ZNF17	561	P17021
FRQKVTLIRHQRTHT	ZNF169	411	Q14929
KSYNQRVHLTQHQRV	ZKSCAN5	381	Q9Y2L8
TFRVSSQLIQHQRIH	ZFP3	261	Q96NJ6
QPHHRRSKSQQVRFK	INSYN2B	26	A6NMK8
RRFHQSTKLIQHQRV	MZF1	716	P28698