Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	extracellular matrix structural constituent	DPT SPARC LAMB3 SSPOP THBS1 FBN1 SPON1 MUC4	7.83e-06	188	107	8	GO:0005201
GeneOntologyMolecularFunction	RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	NANOGP8 NANOG	1.69e-04	4	107	2	GO:0001010
GeneOntologyBiologicalProcess	bone development	CFH PAPPA2 SPARC LRRK1 CR2 SLC10A7 THBS1 FBN1 AKAP13	8.29e-06	264	105	9	GO:0060348
GeneOntologyCellularComponent	extracellular matrix	DPT SPARC GDF15 KERA LAMB3 MUC5B SSPOP LRIG3 THBS1 FBN1 TIMP2 ADAMTS9 OTOGL SPON1 CCN2 MUC4	1.98e-07	656	106	16	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	DPT SPARC GDF15 KERA LAMB3 MUC5B SSPOP LRIG3 THBS1 FBN1 TIMP2 ADAMTS9 OTOGL SPON1 CCN2 MUC4	2.06e-07	658	106	16	GO:0030312
GeneOntologyCellularComponent	collagen-containing extracellular matrix	DPT SPARC GDF15 LAMB3 SSPOP THBS1 FBN1 TIMP2 ADAMTS9 SPON1 CCN2 MUC4	1.58e-05	530	106	12	GO:0062023
MousePheno	abnormal hindlimb morphology	PAPPA2 GDF5 SPARC HCAR1 MC3R C1RL PGAP4 LRRK1 SLC10A7 TG THBS1 FBN1 TIMP2 SPON1 PAPPA CCN2	3.15e-07	576	85	16	MP:0000556
MousePheno	abnormal pelvic girdle bone morphology	PAPPA2 HCAR1 C1RL LRRK1 TG FBN1 PAPPA	9.44e-07	87	85	7	MP:0004509
MousePheno	abnormal tibia morphology	PAPPA2 GDF5 SPARC HCAR1 C1RL PGAP4 LRRK1 SLC10A7 TG FBN1 PAPPA CCN2	2.63e-06	375	85	12	MP:0000558
MousePheno	abnormal hindlimb zeugopod morphology	PAPPA2 GDF5 SPARC HCAR1 C1RL PGAP4 LRRK1 SLC10A7 TG FBN1 PAPPA CCN2	3.09e-06	381	85	12	MP:0003857
MousePheno	abnormal limb long bone morphology	PAPPA2 GDF5 SPARC HCAR1 MC3R C1RL PGAP4 LRRK1 SLC10A7 TG FBN1 SPON1 PAPPA CCN2	7.56e-06	568	85	14	MP:0011504
MousePheno	abnormal limb morphology	MYT1L PAPPA2 GDF5 SPARC HCAR1 MC3R C1RL PGAP4 LRRK1 SLC10A7 TG HIVEP3 LRIG3 THBS1 FBN1 TIMP2 SPON1 PAPPA CCN2	9.92e-06	1028	85	19	MP:0002109
MousePheno	abnormal radius morphology	PAPPA2 GDF5 LRRK1 SLC10A7 FBN1 CCN2	1.02e-05	82	85	6	MP:0000552
MousePheno	abnormal limb bone morphology	PAPPA2 GDF5 SPARC HCAR1 MC3R C1RL PGAP4 LRRK1 SLC10A7 TG FBN1 SPON1 PAPPA CCN2	1.10e-05	587	85	14	MP:0002115
MousePheno	abnormal forelimb zeugopod morphology	PAPPA2 GDF5 LRRK1 SLC10A7 FBN1 CCN2	3.57e-05	102	85	6	MP:0003855
MousePheno	limbs/digits/tail phenotype	MYT1L PAPPA2 GDF5 SPARC HCAR1 MC3R C1RL PGAP4 LRRK1 SLC10A7 TG HIVEP3 LRIG3 THBS1 FBN1 TIMP2 ADAMTS9 SPON1 PAPPA CCN2	4.96e-05	1258	85	20	MP:0005371
MousePheno	abnormal long bone morphology	PAPPA2 GDF5 SPARC HCAR1 MC3R C1RL PGAP4 LRRK1 SLC10A7 TG FBN1 SPON1 PAPPA CCN2	5.24e-05	676	85	14	MP:0003723
MousePheno	short radius	PAPPA2 GDF5 SLC10A7 FBN1	9.85e-05	40	85	4	MP:0004355
MousePheno	decreased radius size	PAPPA2 GDF5 SLC10A7 FBN1	9.85e-05	40	85	4	MP:0030886
MousePheno	abnormal forelimb morphology	PAPPA2 GDF5 SPARC LRRK1 SLC10A7 FBN1 CCN2	1.19e-04	182	85	7	MP:0000550
MousePheno	short femur	PAPPA2 GDF5 MC3R LRRK1 SLC10A7 TG	1.22e-04	127	85	6	MP:0003109
MousePheno	decreased femur size	PAPPA2 GDF5 MC3R LRRK1 SLC10A7 TG	1.38e-04	130	85	6	MP:0030825
MousePheno	abnormal ulna morphology	PAPPA2 GDF5 LRRK1 FBN1 CCN2	1.56e-04	84	85	5	MP:0005108
MousePheno	decreased lean body mass	TSGA13 SPARC GDF15 MC3R C1RL LRRK1 TG FBN1 PAPPA VPS13B	1.75e-04	407	85	10	MP:0003961
MousePheno	abnormal forelimb stylopod morphology	PAPPA2 GDF5 SPARC LRRK1 SLC10A7	2.40e-04	92	85	5	MP:0003854
MousePheno	abnormal humerus morphology	PAPPA2 GDF5 SPARC LRRK1 SLC10A7	2.40e-04	92	85	5	MP:0005296
MousePheno	short tibia	PAPPA2 GDF5 PGAP4 LRRK1 SLC10A7 TG FBN1 PAPPA	2.57e-04	274	85	8	MP:0002764
MousePheno	abnormal appendicular skeleton morphology	PAPPA2 GDF5 SPARC HCAR1 MC3R C1RL PGAP4 LRRK1 SLC10A7 SSPOP TG FBN1 SPON1 PAPPA CCN2	2.96e-04	896	85	15	MP:0009250
MousePheno	abnormal femur morphology	PAPPA2 GDF5 MC3R LRRK1 SLC10A7 TG SPON1	3.21e-04	214	85	7	MP:0000559
MousePheno	abnormal hindlimb stylopod morphology	PAPPA2 GDF5 MC3R LRRK1 SLC10A7 TG SPON1	3.30e-04	215	85	7	MP:0003856
MousePheno	decreased susceptibility to osteoporosis	LRRK1 HIVEP3	3.61e-04	5	85	2	MP:0012072
MousePheno	abnormal susceptibility to osteoporosis	LRRK1 HIVEP3	3.61e-04	5	85	2	MP:0012070
MousePheno	abnormal trabecular bone morphology	SPARC LRRK1 SLC10A7 HIVEP3 FZD9 FBN1 SPON1 CCN2	3.67e-04	289	85	8	MP:0000130
MousePheno	abnormal skeleton physiology	SELP GDF5 SPARC PGAP4 LRRK1 SLC10A7 HIVEP3 FZD9 FBN1 SPON1 PAPPA CCN2	4.20e-04	632	85	12	MP:0001533
MousePheno	abnormal bone volume	LRRK1 SLC10A7 HIVEP3 FZD9 FBN1 SPON1	6.42e-04	173	85	6	MP:0010874
Domain	Sushi_SCR_CCP_dom	SELP CFH PAPPA2 C1RL CR2 F13B PAPPA	2.66e-08	57	103	7	IPR000436
Domain	Sushi	SELP CFH PAPPA2 CR2 F13B PAPPA	4.03e-07	52	103	6	PF00084
Domain	CCP	SELP CFH PAPPA2 CR2 F13B PAPPA	5.06e-07	54	103	6	SM00032
Domain	SUSHI	SELP CFH PAPPA2 CR2 F13B PAPPA	6.31e-07	56	103	6	PS50923
Domain	TSP_1	THSD7B SSPOP THBS1 ADAMTS9 SPON1 CCN2	1.28e-06	63	103	6	PF00090
Domain	TSP1	THSD7B SSPOP THBS1 ADAMTS9 SPON1 CCN2	1.54e-06	65	103	6	SM00209
Domain	TSP1_rpt	THSD7B SSPOP THBS1 ADAMTS9 SPON1 CCN2	1.54e-06	65	103	6	IPR000884
Domain	TSP1	THSD7B SSPOP THBS1 ADAMTS9 SPON1 CCN2	1.54e-06	65	103	6	PS50092
Domain	CTCK_2	DAND5 MUC5B SSPOP CCN2	1.01e-05	25	103	4	PS01225
Domain	Peptidase_M43	PAPPA2 PAPPA	3.01e-05	2	103	2	IPR008754
Domain	Peptidase_M43	PAPPA2 PAPPA	3.01e-05	2	103	2	PF05572
Domain	VWFC_1	MUC5B SSPOP THBS1 CCN2	4.49e-05	36	103	4	PS01208
Domain	VWFC_2	MUC5B SSPOP THBS1 CCN2	5.57e-05	38	103	4	PS50184
Domain	VWC	MUC5B SSPOP THBS1 CCN2	5.57e-05	38	103	4	SM00214
Domain	uDENN	DENND2B MADD DENND2C	5.67e-05	14	103	3	SM00800
Domain	uDENN	DENND2B MADD DENND2C	7.06e-05	15	103	3	PF03456
Domain	VWF_dom	MUC5B SSPOP THBS1 CCN2	8.31e-05	42	103	4	IPR001007
Domain	DENN	DENND2B MADD DENND2C	8.66e-05	16	103	3	SM00799
Domain	VWF_type-D	MUC5B SSPOP MUC4	8.66e-05	16	103	3	IPR001846
Domain	DENN	DENND2B MADD DENND2C	8.66e-05	16	103	3	PF02141
Domain	VWFD	MUC5B SSPOP MUC4	8.66e-05	16	103	3	PS51233
Domain	dDENN	DENND2B MADD DENND2C	8.66e-05	16	103	3	PF03455
Domain	UDENN	DENND2B MADD DENND2C	8.66e-05	16	103	3	PS50946
Domain	DDENN	DENND2B MADD DENND2C	8.66e-05	16	103	3	PS50947
Domain	VWD	MUC5B SSPOP MUC4	8.66e-05	16	103	3	SM00216
Domain	dDENN	DENND2B MADD DENND2C	8.66e-05	16	103	3	SM00801
Domain	dDENN_dom	DENND2B MADD DENND2C	8.66e-05	16	103	3	IPR005112
Domain	uDENN_dom	DENND2B MADD DENND2C	8.66e-05	16	103	3	IPR005113
Domain	DENN	DENND2B MADD DENND2C	8.66e-05	16	103	3	PS50211
Domain	DENN_dom	DENND2B MADD DENND2C	8.66e-05	16	103	3	IPR001194
Domain	VWD	MUC5B SSPOP MUC4	8.66e-05	16	103	3	PF00094
Domain	Myxo_disulph_rpt	PAPPA2 PAPPA	9.00e-05	3	103	2	IPR011936
Domain	CTCK_1	MUC5B SSPOP CCN2	1.25e-04	18	103	3	PS01185
Domain	LamGL	PAPPA2 PAPPA	1.79e-04	4	103	2	SM00560
Domain	LamG-like	PAPPA2 PAPPA	1.79e-04	4	103	2	IPR006558
Domain	VWA_N	CACHD1 CACNA2D3	2.98e-04	5	103	2	IPR013608
Domain	VWA_N	CACHD1 CACNA2D3	2.98e-04	5	103	2	PF08399
Domain	Cys_knot_C	MUC5B SSPOP CCN2	3.43e-04	25	103	3	IPR006207
Domain	VWC	MUC5B THBS1 CCN2	4.83e-04	28	103	3	PF00093
Domain	Notch_dom	PAPPA2 PAPPA	6.21e-04	7	103	2	IPR000800
Domain	Notch	PAPPA2 PAPPA	6.21e-04	7	103	2	PF00066
Domain	NL	PAPPA2 PAPPA	6.21e-04	7	103	2	SM00004
Domain	Frizzled	FZD9 FZD10	1.60e-03	11	103	2	IPR000539
Domain	Frizzled	FZD9 FZD10	1.60e-03	11	103	2	PF01534
Domain	Frizzled	FZD9 FZD10	1.60e-03	11	103	2	SM01330
Domain	C8	MUC5B SSPOP	1.92e-03	12	103	2	PF08742
Domain	TIL	MUC5B SSPOP	1.92e-03	12	103	2	PF01826
Domain	Unchr_dom_Cys-rich	MUC5B SSPOP	2.26e-03	13	103	2	IPR014853
Domain	C8	MUC5B SSPOP	2.26e-03	13	103	2	SM00832
Domain	TIL_dom	MUC5B SSPOP	2.62e-03	14	103	2	IPR002919
Domain	EGF_1	SELP LAMB3 SSPOP THBS1 FBN1 MUC4	2.90e-03	255	103	6	PS00022
Domain	Glyco_hormone_CN	MUC5B CCN2	3.02e-03	15	103	2	IPR006208
Domain	Cys_knot	MUC5B CCN2	3.02e-03	15	103	2	PF00007
Domain	Frizzled/SFRP	FZD9 FZD10	3.44e-03	16	103	2	IPR015526
Domain	EGF_2	SELP LAMB3 SSPOP THBS1 FBN1 MUC4	3.50e-03	265	103	6	PS01186
Domain	VWC_out	MUC5B SSPOP	4.84e-03	19	103	2	SM00215
Domain	FRI	FZD9 FZD10	5.36e-03	20	103	2	SM00063
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	MUC5B THSD7B SSPOP THBS1 ADAMTS9 SPON1 MUC4	9.76e-08	68	79	7	M27303
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	GALNT15 MUC5B THSD7B SSPOP THBS1 ADAMTS9 SPON1 MUC4	1.63e-07	109	79	8	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	GALNT15 MUC5B THSD7B SSPOP THBS1 ADAMTS9 SPON1 MUC4	1.88e-07	111	79	8	M27416
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	KERA MUC5B THSD7B SSPOP THBS1 ADAMTS9 SPON1 MUC4	1.31e-06	143	79	8	M27275
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	THSD7B SSPOP THBS1 ADAMTS9 SPON1	2.41e-06	39	79	5	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	THSD7B SSPOP THBS1 ADAMTS9 SPON1	2.41e-06	39	79	5	MM15165
Pathway	REACTOME_DISEASES_OF_METABOLISM	KERA MUC5B THSD7B SSPOP THBS1 ADAMTS9 SPON1 MUC4	7.70e-05	250	79	8	M27554
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	THSD7B SSPOP THBS1 ADAMTS9 SPON1 CCN2	1.39e-07	75	109	6	20637190
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	CFH DPT SPARC THBS1 FBN1 TIMP2 PAPPA CCN2	1.22e-06	248	109	8	24006456
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	DPT SSPOP THBS1 ADAMTS9 SPON1	1.81e-06	64	109	5	22261194
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	CACHD1 THSD7B SSPOP MADD ASAP2 MACF1	3.59e-06	130	109	6	12421765
Pubmed	MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons.	GALNT15 PAPPA2 PAPPA CCN2	4.43e-06	35	109	4	22407321
Pubmed	Comprehensive proteomic characterization of stem cell-derived extracellular matrices.	SPARC GDF15 THBS1 FBN1 CCN2	7.84e-06	86	109	5	28327460
Pubmed	Pregnancy-associated plasma protein-A2 (PAPP-A2): tissue expression and biological consequences of gene knockout in mice.	PAPPA2 PAPPA	9.73e-06	2	109	2	21586553
Pubmed	Functional evidence that the self-renewal gene NANOG regulates human tumor development.	NANOGP8 NANOG	9.73e-06	2	109	2	19415763
Pubmed	Growth differentiation factor-15 induces expression of ATP-binding cassette transporter A1 through PI3-K/PKCζ/SP1 pathway in THP-1 macrophages.	ABCA1 GDF15	9.73e-06	2	109	2	24462860
Pubmed	Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons.	MADD DENND2C	9.73e-06	2	109	2	15007167
Pubmed	Growth differentiation factor-15 (GDF-15) suppresses in vitro angiogenesis through a novel interaction with connective tissue growth factor (CCN2).	GDF15 CCN2	9.73e-06	2	109	2	23280549
Pubmed	Expression of mucins in mucoid otitis media.	MUC5B MUC4	9.73e-06	2	109	2	14690056
Pubmed	Growth differentiation factor 15, ischemia modified albumin and pregnancy-associated plasma protein A in patients with coronary artery disease.	GDF15 PAPPA	9.73e-06	2	109	2	25016703
Pubmed	Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin.	PAPPA2 PAPPA	9.73e-06	2	109	2	11513734
Pubmed	Factor H binds to washed human platelets.	CFH THBS1	9.73e-06	2	109	2	15634279
Pubmed	The role of matricellular proteins thrombospondin-1 and osteonectin during RPE cell migration in proliferative vitreoretinopathy.	SPARC THBS1	9.73e-06	2	109	2	12658547
Pubmed	Attenuation of expression of extracellular matrix genes with siRNAs to Sparc and Ctgf in skin fibroblasts of CTGF transgenic mice.	SPARC CCN2	9.73e-06	2	109	2	21978691
Pubmed	Expression and prognostic significance of THBS1, Cyr61 and CTGF in esophageal squamous cell carcinoma.	THBS1 CCN2	9.73e-06	2	109	2	19698122
Pubmed	Pregnancy associated plasma protein-A as a prognostic biomarker of all-cause mortality and cardiovascular events in patients presenting with chest pain: a systematic review.	PAPPA2 PAPPA	9.73e-06	2	109	2	29144175
Pubmed	SPARC accelerates biliary tract cancer progression through CTGF-mediated tumor-stroma interactions: SPARC as a prognostic marker of survival after neoadjuvant therapy.	SPARC CCN2	9.73e-06	2	109	2	37330435
Pubmed	Nanog1 in NTERA-2 and recombinant NanogP8 from somatic cancer cells adopt multiple protein conformations and migrate at multiple M.W species.	NANOGP8 NANOG	9.73e-06	2	109	2	24598770
Pubmed	Differential expression of nanog1 and nanogp8 in colon cancer cells.	NANOGP8 NANOG	9.73e-06	2	109	2	22079639
Pubmed	Complex formation of human thrombospondin with osteonectin.	SPARC THBS1	9.73e-06	2	109	2	3402455
Pubmed	Plasma MIC-1 and PAPP-a levels are decreased among women presenting to an early pregnancy assessment unit, have fetal viability confirmed but later miscarry.	GDF15 PAPPA	9.73e-06	2	109	2	24069146
Pubmed	Expression of NANOG and NANOGP8 in a variety of undifferentiated and differentiated human cells.	NANOGP8 NANOG	9.73e-06	2	109	2	21136380
Pubmed	Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment.	LAMB3 THBS1 CCN2	1.06e-05	14	109	3	36347239
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	CFH GDF5 GDF15 KIF12 CR2 ULBP3 F13B MADD MACF1 TNFRSF19 CCN2 CCL24	1.11e-05	824	109	12	20237496
Pubmed	Mapping Extracellular Protein-Protein Interactions Using Extracellular Proximity Labeling (ePL).	DOCK8 GDF15 LAMB3 THBS1 FBN1 TIMP2 CCN2	1.35e-05	247	109	7	39238192
Pubmed	Sox9 in mouse urogenital sinus epithelium mediates elongation of prostatic buds and expression of genes involved in epithelial cell migration.	THBS1 ADAMTS9 TNS4	1.63e-05	16	109	3	31669249
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	DPT SPARC SSPOP THBS1 FBN1 MUC4	1.96e-05	175	109	6	28071719
Pubmed	Murine inner cell mass-derived lineages depend on Sall4 function.	NANOGP8 SPARC NANOG	2.36e-05	18	109	3	17060609
Pubmed	The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1.	NANOGP8 NANOG	2.91e-05	3	109	2	30814124
Pubmed	Multiple phases in regulation of Nanog expression during pre-implantation development.	NANOGP8 NANOG	2.91e-05	3	109	2	26660234
Pubmed	Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog.	NANOGP8 NANOG	2.91e-05	3	109	2	18177668
Pubmed	Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast.	NANOGP8 NANOG	2.91e-05	3	109	2	24929238
Pubmed	Nanog and transcriptional networks in embryonic stem cell pluripotency.	NANOGP8 NANOG	2.91e-05	3	109	2	17211451
Pubmed	The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus.	NANOGP8 NANOG	2.91e-05	3	109	2	15502159
Pubmed	Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis.	NANOGP8 NANOG	2.91e-05	3	109	2	20574542
Pubmed	lincRNAs act in the circuitry controlling pluripotency and differentiation.	NANOGP8 NANOG	2.91e-05	3	109	2	21874018
Pubmed	Cell signalling regulates dynamics of Nanog distribution in embryonic stem cell populations.	NANOGP8 NANOG	2.91e-05	3	109	2	23054952
Pubmed	CrxOS maintains the self-renewal capacity of murine embryonic stem cells.	NANOGP8 NANOG	2.91e-05	3	109	2	19800316
Pubmed	Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog.	NANOGP8 NANOG	2.91e-05	3	109	2	26975336
Pubmed	Nanog suppresses cell migration by downregulating thymosin β4 and Rnd3.	NANOGP8 NANOG	2.91e-05	3	109	2	23329853
Pubmed	MicroRNA-145 is downregulated in glial tumors and regulates glioma cell migration by targeting connective tissue growth factor.	SPARC CCN2	2.91e-05	3	109	2	23390502
Pubmed	Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming.	NANOGP8 NANOG	2.91e-05	3	109	2	23665121
Pubmed	Ectopic overexpression of Nanog induces tumorigenesis in non-tumorous fibroblasts.	NANOGP8 NANOG	2.91e-05	3	109	2	26733157
Pubmed	Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features.	NANOGP8 NANOG	2.91e-05	3	109	2	16501172
Pubmed	Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells.	NANOGP8 NANOG	2.91e-05	3	109	2	19582141
Pubmed	Nanog is the gateway to the pluripotent ground state.	NANOGP8 NANOG	2.91e-05	3	109	2	19703398
Pubmed	Nanog Fluctuations in Embryonic Stem Cells Highlight the Problem of Measurement in Cell Biology.	NANOGP8 NANOG	2.91e-05	3	109	2	28636920
Pubmed	A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis.	NANOGP8 NANOG	2.91e-05	3	109	2	20539761
Pubmed	Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes.	NANOGP8 NANOG	2.91e-05	3	109	2	18584034
Pubmed	Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells.	NANOGP8 NANOG	2.91e-05	3	109	2	21969378
Pubmed	The phosphoinositide-3-kinase/Akt pathway mediates the transient increase in Nanog expression during differentiation of F9 cells.	NANOGP8 NANOG	2.91e-05	3	109	2	20661723
Pubmed	NANOG restores the impaired myogenic differentiation potential of skeletal myoblasts after multiple population doublings.	NANOGP8 NANOG	2.91e-05	3	109	2	29245050
Pubmed	Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation.	NANOGP8 NANOG	2.91e-05	3	109	2	15494369
Pubmed	Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog.	NANOGP8 NANOG	2.91e-05	3	109	2	14728807
Pubmed	Identification of Key Prognostic Biomarker and Its Correlation with Immune Infiltrates in Pancreatic Ductal Adenocarcinoma.	SPARC FBN1	2.91e-05	3	109	2	32934754
Pubmed	Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice.	CFH CR2	2.91e-05	3	109	2	19828624
Pubmed	Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions.	NANOGP8 NANOG	2.91e-05	3	109	2	21194951
Pubmed	Identification and regulation of a stage-specific stem cell niche enriched by Nanog-positive spermatogonial stem cells in the mouse testis.	NANOGP8 NANOG	2.91e-05	3	109	2	22388986
Pubmed	Nanog promotes transfer of pluripotency after cell fusion.	NANOGP8 NANOG	2.91e-05	3	109	2	16791199
Pubmed	Heparan sulfate regulates self-renewal and pluripotency of embryonic stem cells.	NANOGP8 NANOG	2.91e-05	3	109	2	18024963
Pubmed	The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells.	NANOGP8 NANOG	2.91e-05	3	109	2	27125671
Pubmed	Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells.	NANOGP8 NANOG	2.91e-05	3	109	2	25410303
Pubmed	Genome editing demonstrates that the -5 kb Nanog enhancer regulates Nanog expression by modulating RNAPII initiation and/or recruitment.	NANOGP8 NANOG	2.91e-05	3	109	2	33334884
Pubmed	Forced expression of Nanog in hematopoietic stem cells results in a gammadeltaT-cell disorder.	NANOGP8 NANOG	2.91e-05	3	109	2	17360937
Pubmed	Nanog dynamics in single embryonic stem cells.	NANOGP8 NANOG	2.91e-05	3	109	2	26760119
Pubmed	Nanog is dispensable for the generation of induced pluripotent stem cells.	NANOGP8 NANOG	2.91e-05	3	109	2	24461999
Pubmed	Locating and Characterizing a Transgene Integration Site by Nanopore Sequencing.	NANOGP8 NANOG	2.91e-05	3	109	2	30837263
Pubmed	Nanog induces hyperplasia without initiating tumors.	NANOGP8 NANOG	2.91e-05	3	109	2	25173648
Pubmed	Distinct Contributions of Tryptophan Residues within the Dimerization Domain to Nanog Function.	NANOGP8 NANOG	2.91e-05	3	109	2	27939294
Pubmed	Identification of genes regulated by nanog which is involved in ES cells pluripotency and early differentiation.	NANOGP8 NANOG	2.91e-05	3	109	2	18442017
Pubmed	A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal.	NANOGP8 NANOG	2.91e-05	3	109	2	16790525
Pubmed	Primitive endoderm differentiates via a three-step mechanism involving Nanog and RTK signaling.	NANOGP8 NANOG	2.91e-05	3	109	2	22172669
Pubmed	Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients.	PAPPA2 PAPPA	2.91e-05	3	109	2	18805800
Pubmed	Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.	NANOGP8 NANOG	2.91e-05	3	109	2	19447925
Pubmed	The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells.	NANOGP8 NANOG	2.91e-05	3	109	2	30846691
Pubmed	Generation of germline-competent induced pluripotent stem cells.	NANOGP8 NANOG	2.91e-05	3	109	2	17554338
Pubmed	Genetic Study of IL6, GDF5 and PAPPA2 in Association with Developmental Dysplasia of the Hip.	PAPPA2 GDF5	2.91e-05	3	109	2	34203285
Pubmed	BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo.	GDF5 DAND5	2.91e-05	3	109	2	22202776
Pubmed	Expression of Nanog gene promotes NIH3T3 cell proliferation.	NANOGP8 NANOG	2.91e-05	3	109	2	16259959
Pubmed	A novel NK-type homeobox gene, ENK (early embryo specific NK), preferentially expressed in embryonic stem cells.	NANOGP8 NANOG	2.91e-05	3	109	2	12609610
Pubmed	Cutting edge: Hypoxia-induced Nanog favors the intratumoral infiltration of regulatory T cells and macrophages via direct regulation of TGF-β1.	NANOGP8 NANOG	2.91e-05	3	109	2	24227785
Pubmed	The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis.	NANOGP8 NANOG	2.91e-05	3	109	2	23770853
Pubmed	A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.	CFH CR2	2.91e-05	3	109	2	3782802
Pubmed	Nanog-independent reprogramming to iPSCs with canonical factors.	NANOGP8 NANOG	2.91e-05	3	109	2	24527385
Pubmed	Aromatic residues in the C-terminal domain 2 are required for Nanog to mediate LIF-independent self-renewal of mouse embryonic stem cells.	NANOGP8 NANOG	2.91e-05	3	109	2	18086680
Pubmed	Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli.	THBS1 CCN2	2.91e-05	3	109	2	16270194
Pubmed	Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells.	NANOGP8 NANOG	2.91e-05	3	109	2	17204467
Pubmed	Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR.	PAPPA2 PAPPA	2.91e-05	3	109	2	29532882
Pubmed	Chromatin decondensation and nuclear softening accompany Nanog downregulation in embryonic stem cells.	NANOGP8 NANOG	2.91e-05	3	109	2	23200040
Pubmed	NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.	NANOGP8 NANOG	2.91e-05	3	109	2	26751055
Pubmed	Altered placental expression of PAPPA2 does not affect birth weight in mice.	PAPPA2 PAPPA	2.91e-05	3	109	2	20642865
Pubmed	Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells.	NANOGP8 NANOG	2.91e-05	3	109	2	17352742
Pubmed	OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.	NANOGP8 NANOG	2.91e-05	3	109	2	23178592
Pubmed	Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency.	NANOGP8 NANOG	2.91e-05	3	109	2	25005472
Pubmed	Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts.	NANOGP8 NANOG	2.91e-05	3	109	2	16773043
Pubmed	mNanog possesses dorsal mesoderm-inducing ability by modulating both BMP and Activin/nodal signaling in Xenopus ectodermal cells.	NANOGP8 NANOG	2.91e-05	3	109	2	23071603
Pubmed	NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis.	NANOGP8 NANOG	2.91e-05	3	109	2	21119109
Cytoband	1q32	CFH LAMB3 CR2	2.22e-04	49	109	3	1q32
Cytoband	9p24.3	DOCK8 DMRT1	4.99e-04	14	109	2	9p24.3
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELP CFH PAPPA2 C1RL CR2 F13B PAPPA	1.77e-09	57	68	7	1179
GeneFamily	Pappalysins\|Sushi domain containing	PAPPA2 PAPPA	1.39e-05	2	68	2	897
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND2B MADD DENND2C	1.10e-04	25	68	3	504
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD9 FZD10	7.50e-04	11	68	2	286
GeneFamily	CD molecules\|Mucins	MUC5B MUC4	2.79e-03	21	68	2	648
Coexpression	NABA_MATRISOME	PAPPA2 GDF5 DPT SPARC GDF15 KERA LAMB3 MUC5B SSPOP F13B THBS1 FBN1 TIMP2 ADAMTS9 OTOGL SPON1 PAPPA CCN2 CCL24 MUC4	4.17e-09	1008	107	20	MM17056
Coexpression	NABA_MATRISOME	PAPPA2 GDF5 DPT SPARC GDF15 KERA LAMB3 MUC5B SSPOP F13B THBS1 FBN1 TIMP2 ADAMTS9 SPON1 PAPPA CCN2 CCL24 MUC4	3.22e-08	1026	107	19	M5889
Coexpression	NABA_ECM_GLYCOPROTEINS	DPT SPARC LAMB3 SSPOP THBS1 FBN1 OTOGL SPON1 CCN2	9.30e-08	191	107	9	MM17059
Coexpression	NABA_CORE_MATRISOME	DPT SPARC KERA LAMB3 SSPOP THBS1 FBN1 OTOGL SPON1 CCN2	1.66e-07	270	107	10	MM17057
Coexpression	LIU_PROSTATE_CANCER_DN	DPT SPARC ETS2 LAMB3 PGAP4 CACHD1 DENND2B FBN1 TIMP2 SPON1 TNS4 MUC4	8.44e-07	493	107	12	M19391
Coexpression	KIM_GLIS2_TARGETS_UP	CFH DPT SPARC FBN1 SPON1 CCN2	1.45e-06	86	107	6	M2259
Coexpression	NABA_ECM_GLYCOPROTEINS	DPT SPARC LAMB3 SSPOP THBS1 FBN1 SPON1 CCN2	1.47e-06	196	107	8	M3008
Coexpression	NABA_CORE_MATRISOME	DPT SPARC KERA LAMB3 SSPOP THBS1 FBN1 SPON1 CCN2	1.98e-06	275	107	9	M5884
Coexpression	KIM_GLIS2_TARGETS_UP	CFH DPT SPARC FBN1 SPON1 CCN2	3.94e-06	102	107	6	MM1064
Coexpression	CUI_DEVELOPING_HEART_C3_FIBROBLAST_LIKE_CELL	DPT SPARC FBN1 TIMP2 SPON1 CCN2	8.70e-06	117	107	6	M39300
Coexpression	FOROUTAN_PRODRANK_TGFB_EMT_UP	ABCA1 SPARC ETS2 THBS1 FBN1 TIMP2 CCN2	1.12e-05	185	107	7	M42503
Coexpression	FOROUTAN_TGFB_EMT_UP	ABCA1 SPARC ETS2 THBS1 FBN1 TIMP2 CCN2	1.43e-05	192	107	7	M42501
Coexpression	AIZARANI_LIVER_C21_STELLATE_CELLS_1	CFH DPT SPARC THBS1 FBN1 TIMP2 CCN2	1.52e-05	194	107	7	M39122
Coexpression	WONG_ADULT_TISSUE_STEM_MODULE	SELP DPT ABCA1 SPARC ETS2 PGAP4 CR2 THBS1 SPON1 MACF1 CCN2 MUC4	3.91e-05	721	107	12	M1999
Coexpression	HAY_BONE_MARROW_STROMAL	CFH DPT CACHD1 THSD7B DENND2B LRIG3 FBN1 ADAMTS9 OTOGL PAPPA TNFRSF19 CCN2	7.06e-05	767	107	12	M39209
Coexpression	RAO_BOUND_BY_SALL4	CFH NANOGP8 NANOG DENND2C SEC16A IRF2BPL CCN2	7.10e-05	247	107	7	MM1081
Coexpression	DESCARTES_FETAL_SPLEEN_MEGAKARYOCYTES	SELP THBS1 ASAP2 DENND2C MED12L	1.06e-04	114	107	5	M40293
Coexpression	IL21_UP.V1_DN	KRT32 F13B TG CCL24 DMRT1 CACNA2D3	1.18e-04	186	107	6	M2824
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HNBML5	MYT1L PAPPA2 PTPN5 HIVEP3 CMIP MED12L PAPPA IRF2BPL TRIM36	1.24e-04	465	107	9	M39066
Coexpression	JEON_SMAD6_TARGETS_UP	THBS1 FBN1 TIMP2	1.26e-04	24	107	3	M4592
Coexpression	FOROUTAN_INTEGRATED_TGFB_EMT_UP	SPARC THBS1 FBN1 TIMP2 CCN2	1.35e-04	120	107	5	M42505
Coexpression	TRAVAGLINI_LUNG_MYOFIBROBLAST_CELL	CFH DPT TNFRSF19 CCN2	1.47e-04	65	107	4	M41673
Coexpression	CUI_DEVELOPING_HEART_COMPACT_VENTRICULAR_CARDIOMYOCYTE	DPT SPARC FBN1 TIMP2	1.47e-04	65	107	4	M39309
Coexpression	SAUL_SEN_MAYO	GDF15 ETS2 TIMP2 PAPPA CCL24	1.52e-04	123	107	5	MM16098
Coexpression	SAUL_SEN_MAYO	GDF15 ETS2 TIMP2 PAPPA CCL24	1.58e-04	124	107	5	M45803
Coexpression	GSE41176_WT_VS_TAK1_KO_UNSTIM_BCELL_DN	SELP KRT32 KIF2B MED12L TNFRSF19 TNS4	1.70e-04	199	107	6	M9941
Coexpression	GSE8921_UNSTIM_0H_VS_TLR1_2_STIM_MONOCYTE_6H_DN	ABCA1 DENND2B DZANK1 AKAP13 IRF2BPL RPS6KL1	1.75e-04	200	107	6	M6404
Coexpression	GSE2770_TGFB_AND_IL4_VS_IL12_TREATED_ACT_CD4_TCELL_6H_UP	MON2 DIP2B DOCK8 LAMB3 MADD AKAP13	1.75e-04	200	107	6	M6096
Coexpression	WANG_SMARCE1_TARGETS_UP	CFH DIP2B ABCA1 SLC12A8 DENND2B TIMP2 TNFRSF19	2.08e-04	294	107	7	M1804
Coexpression	MURARO_PANCREAS_DUCTAL_CELL	CFH ABCA1 GDF15 RNF44 ETS2 LAMB3 C1RL THBS1 ASAP2 TIMP2 ADAMTS9 MACF1 AKAP13 CCN2 MAP3K21	2.11e-04	1276	107	15	M39173
Coexpression	HALLMARK_COAGULATION	CFH SPARC F13B THBS1 FBN1	2.60e-04	138	107	5	M5946
CoexpressionAtlas	Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3	CFH DPT SPARC THBS1 FBN1 SPON1	8.22e-06	97	104	6	GSM777043_100
CoexpressionAtlas	DevelopingGonad_e18.5_testes_emap-11164_k-means-cluster#4_top-relative-expression-ranked_1000	DPT ABCA1 SPARC GDF15 TMEM114 FBN1 TIMP2 DMRT1 MAP3K21	1.40e-05	293	104	9	gudmap_developingGonad_e18.5_testes_1000_k4
CoexpressionAtlas	DevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_top-relative-expression-ranked_500	PAPPA2 DOCK8 KIF12 NCOR1 THBS1 ADAMTS9 SPON1 MED12L AKAP13 MAP3K21	2.84e-05	402	104	10	gudmap_developingKidney_e15.5_anlage of loop of Henle_500
CoexpressionAtlas	Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2	CFH DPT SPARC THBS1 FBN1	6.15e-05	85	104	5	GSM777067_100
ToppCell	medial-2-mesenchymal-Myofibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GALNT15 CFH PAPPA2 DPT RAB40A FBN1 SPON1 PAPPA CCN2	1.57e-09	199	109	9	95aae608fa35a9c82b12c6f18937ce636750ca44
ToppCell	medial-mesenchymal-Myofibroblast\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GALNT15 CFH PAPPA2 DPT RAB40A FBN1 SPON1 PAPPA CCN2	1.57e-09	199	109	9	e25acdb5809aaff631cb06dbe4c7e59549a0bdb9
ToppCell	medial-mesenchymal-Myofibroblast-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GALNT15 CFH PAPPA2 DPT RAB40A FBN1 SPON1 PAPPA CCN2	1.57e-09	199	109	9	9ebf4822ff9fa08574edec5dbf4f2a1488f34b1d
ToppCell	distal-mesenchymal-Myofibroblast-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH PAPPA2 DPT KRT32 FBN1 SPON1 PAPPA TNFRSF19 CCN2	1.64e-09	200	109	9	069c8949b33ecfdb6da32992002d4060ff6082bc
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CFH PAPPA2 DPT KERA SPON1 PAPPA CCN2	1.58e-08	181	109	8	9c157de9d3403e092c907599f2a2c16db5b21131
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CFH PAPPA2 DPT KERA SPON1 PAPPA CCN2	1.58e-08	181	109	8	eea943fdcbef0bbaa8578f3296923e874893b405
ToppCell	Basal\|World / shred by cell class for mouse tongue	ABCA1 SPARC LAMB3 CACHD1 ASAP2 PAPPA IRF2BPL TNS4	1.72e-08	183	109	8	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CFH PAPPA2 DPT KERA SPON1 PAPPA CCN2	1.72e-08	183	109	8	bc7dd6a40ec9c773d005c1a46f305d40cdd0a326
ToppCell	PND14-Mesenchymal-Mesenchymal_structural\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH DPT SPARC HIVEP3 FBN1 TIMP2 SPON1 MACF1	2.50e-08	192	109	8	25492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCell	COVID-19-lung-Secretory\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CFH HCAR1 LAMB3 MUC5B CACHD1 LRIG3 TNS4 MUC4	2.50e-08	192	109	8	59261098ccb52306f837f632ebaea45b90ad30fe
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH DPT SPARC HIVEP3 FBN1 TIMP2 SPON1 MACF1	2.50e-08	192	109	8	de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH DPT SPARC HIVEP3 FBN1 TIMP2 SPON1 MACF1	2.82e-08	195	109	8	3a0cad69cfc150a27a0666f612f5294c817197d7
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CFH GDF15 HCAR1 ETS2 CACHD1 LRIG3 MED12L TNS4	2.82e-08	195	109	8	6c9c58322c1df891bb4bab56dacb542c8777bb7d
ToppCell	PND10-Mesenchymal-Mesenchymal_structural\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPT SPARC PTPN5 HIVEP3 FBN1 TIMP2 SPON1 MACF1	2.82e-08	195	109	8	11d421bbbb71425d59cbdd673e052e00d5f0a768
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH DPT SPARC HIVEP3 FBN1 TIMP2 SPON1 MACF1	2.82e-08	195	109	8	2b8ee7990267bb52b7e6ae03f509ffebf8908122
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPT SPARC PTPN5 HIVEP3 FBN1 TIMP2 SPON1 MACF1	2.82e-08	195	109	8	10f307aef8f4d9e71c501d5bcedb84d3be7a4d1b
ToppCell	Fibroblasts-CD34+_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	GALNT15 CFH DPT SPARC FBN1 TIMP2 SPON1 CCN2	3.30e-08	199	109	8	13ff7409e200a0b46cdb7924d15ef33639693622
ToppCell	distal-3-mesenchymal-Myofibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH PAPPA2 DPT FBN1 SPON1 PAPPA TNFRSF19 CCN2	3.30e-08	199	109	8	1f20addc0d138fec02ed6ca4c518169c568de263
ToppCell	distal-mesenchymal-Myofibroblast\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH PAPPA2 DPT KRT32 SPON1 PAPPA TNFRSF19 CCN2	3.43e-08	200	109	8	61854a459385cd9295be37157a8f81a2c227dff3
ToppCell	390C-Fibroblasts\|390C / Donor, Lineage, Cell class and subclass (all cells)	CFH DPT SPARC THBS1 FBN1 SPON1 PAPPA CCN2	3.43e-08	200	109	8	3abe0f017fee6057ba73bd661a2bc8ec9e2bfe38
ToppCell	Skin-Fibroblasts\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	GALNT15 CFH DPT SPARC THBS1 FBN1 TIMP2 SPON1	3.43e-08	200	109	8	f777eadf571a1a6d246da87346a9cb9d511c2e81
ToppCell	cellseq-Mesenchymal-Myocytic-Myocytic_2-SCMF\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GALNT15 CFH PAPPA2 DPT FBN1 SPON1 PAPPA CCN2	3.43e-08	200	109	8	b441b3771fb7d9ee7b7a104afc35e466aace2da2
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CFH FBN1 SPON1 MACF1 PAPPA CCN2	2.55e-07	175	109	7	1799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell	Epithelial-basal_cell\|World / Lineage, Cell type, age group and donor	TRPM6 CFH ETS2 LAMB3 CACHD1 LRIG3 TNS4	2.97e-07	179	109	7	d9be6647ec7b22747dc00dce4ea307b6af412dfa
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CFH DPT KERA FBN1 SPON1 PAPPA CACNA2D3	3.71e-07	185	109	7	7dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PAPPA2 DENND2B THBS1 FBN1 TNFRSF19 CCN2 CACNA2D3	3.71e-07	185	109	7	427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCell	P03\|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DPT SPARC HIVEP3 FBN1 SPON1 MACF1 CCN2	3.71e-07	185	109	7	a07dbe1f76e40734a28826423a5cc64b8e56af5e
ToppCell	P15-Mesenchymal\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CFH DPT SPARC THBS1 FBN1 SPON1 MACF1	4.14e-07	188	109	7	f1ba0b661621a65c91432e62ba73531bdf18e7c1
ToppCell	COVID-19-Heart-EC_3\|Heart / Disease (COVID-19 only), tissue and cell type	SELP ETS2 CACHD1 PTPN5 CMIP ADAMTS9 ARHGAP31	4.44e-07	190	109	7	78e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCell	droplet-Lung-18m-Mesenchymal\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH DPT SPARC FBN1 SPON1 TNFRSF19 CCN2	4.44e-07	190	109	7	0b7200897b2c389632c9b1ee37e272b811555dbc
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH DPT SPARC FBN1 TIMP2 SPON1 MACF1	4.60e-07	191	109	7	44a9a6768084dafc641ad455b65862bfd4cc0cb9
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH DPT SPARC FBN1 SPON1 TNFRSF19 CCN2	4.60e-07	191	109	7	36467322096bc766cd777dae3bfb4e65511e492c
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH DPT SPARC FBN1 SPON1 TNFRSF19 CCN2	4.60e-07	191	109	7	94795daf05061baa3b72a1b01c9e940af86de044
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 CFH DPT THBS1 FBN1 TIMP2 CCN2	4.60e-07	191	109	7	4e4488380379ed29d7898bae4e24221e7c67eb9d
ToppCell	PND28-Mesenchymal-Mesenchymal_structural\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH DPT SPARC FBN1 TIMP2 SPON1 MACF1	4.94e-07	193	109	7	ec81c1afdae2e0433a22c8c1fa1c6232526ff7e7
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH DPT SPARC FBN1 TIMP2 SPON1 MACF1	4.94e-07	193	109	7	30481fb01c7acf85beae10213f038da86bed6777
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPT SPARC HIVEP3 FBN1 TIMP2 SPON1 MACF1	5.29e-07	195	109	7	b616ee6f1d878935d293c8e0a8bbc5b4385301f0
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPT SPARC PTPN5 HIVEP3 FBN1 SPON1 MACF1	5.29e-07	195	109	7	1c1135be421af98cd0077bec1ff2c4158d42aa21
ToppCell	ASK428-Mesenchymal\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	CFH DPT SPARC THBS1 FBN1 SPON1 CCN2	5.29e-07	195	109	7	2b156163975d9a3d3fda1402acd9831d0fdc9e25
ToppCell	ASK428-Mesenchymal-Fibroblast\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	CFH DPT SPARC THBS1 FBN1 SPON1 CCN2	5.29e-07	195	109	7	c269c0d894a0f55da6495b59d4b9abb9f68df684
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPT SPARC PTPN5 HIVEP3 FBN1 SPON1 MACF1	5.29e-07	195	109	7	1f005ee1da66b539bd200aaa98f46edbbc7f12e4
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH DPT SPARC FBN1 SPON1 PAPPA CCN2	5.29e-07	195	109	7	51db90e7611f7d69980878c046505ff34212079b
ToppCell	PND07-Mesenchymal-Mesenchymal_structural\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPT SPARC HIVEP3 FBN1 TIMP2 SPON1 MACF1	5.29e-07	195	109	7	2f9a274b26fc528a85f50933ec2f4db1dc9da0ca
ToppCell	PND10-Mesenchymal\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPT SPARC THBS1 FBN1 TIMP2 SPON1 TNFRSF19	5.48e-07	196	109	7	ace167a40adb7022b365be3c2b1cbd4ba963739a
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH DPT SPARC FBN1 SPON1 MACF1 CCN2	5.48e-07	196	109	7	42e9828222a9663525d571633e8a454c30bfa7f8
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 PAPPA2 GDF15 DUSP15 CACHD1 DENND2B TNFRSF19	5.48e-07	196	109	7	b8350340d86e4524e9616a427e7f2e116a6fb3be
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 SPARC THBS1 FBN1 TIMP2 TNFRSF19 CCN2	5.67e-07	197	109	7	26475b9e4d6bfc0ae818dea13d139888ed7e92f1
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 SPARC THBS1 FBN1 TIMP2 TNFRSF19 CCN2	5.67e-07	197	109	7	155e63b33302a87393ace699b2f6d73abe9c5763
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 SPARC THBS1 FBN1 TIMP2 TNFRSF19 CCN2	5.86e-07	198	109	7	a4005a49cf6709b543994ceb51ecd5dc46197fa9
ToppCell	(2)_Fibroblasts-(23)_Fibro-4\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	GALNT15 CFH GDF5 SPARC FZD9 LRIG3 THBS1	5.86e-07	198	109	7	e0ef49ec0f87cc87b45efa297b9ff6c35b7a2ba9
ToppCell	distal-mesenchymal-Myofibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH PAPPA2 DPT FBN1 SPON1 PAPPA CCN2	5.86e-07	198	109	7	beef5075ba6dcd4d0a447bc4e57efcaf2e93c546
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 SPARC THBS1 FBN1 TIMP2 TNFRSF19 CCN2	5.86e-07	198	109	7	a699b365d3b6149f13f02b2e2ae9b6fdce761848
ToppCell	Fibroblasts-HLA-DRA_high_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	CFH DPT SPARC C1RL DENND2B FBN1 CCN2	5.86e-07	198	109	7	e8c0fbf306fae13e97caa294d7c99a564bd97130
ToppCell	5'-Adult-Distal_Rectal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 GDF15 MUC5B ST6GALNAC6 THBS1 SPON1 MUC4	5.86e-07	198	109	7	db26c20321f9ab102d6484f22ddb2bde684067b1
ToppCell	distal-Epithelial-Basal-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH KRT32 GDF15 LAMB3 CACHD1 LRIG3 TNS4	5.86e-07	198	109	7	dda0bf3a48f738df590ce23b891d82be19e10d66
ToppCell	5'-Parenchyma_lung-Mesenchymal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CFH DPT SPARC FBN1 SPON1 CCN2	5.86e-07	198	109	7	aae663c6da70b6e716edeed50cc7d3962d78e697
ToppCell	Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	CFH DPT SPARC DENND2B FBN1 TIMP2 CCN2	6.06e-07	199	109	7	40de6d4a31cf22efa2864f79e4ec8e2b7bfc9d4a
ToppCell	ILEUM-inflamed-(8)_Fibroblasts\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CFH SPARC DENND2B FBN1 TIMP2 PAPPA CCN2	6.06e-07	199	109	7	3a3e2bb21cd0293622b1a975263e918d9ba24265
ToppCell	ILEUM-inflamed-(8)_Fibroblast\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CFH DPT SPARC DENND2B FBN1 TIMP2 CCN2	6.06e-07	199	109	7	cb3c04b91c8e8080137823b11c76ca0a2adda52d
ToppCell	distal-2-mesenchymal-Myofibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH PAPPA2 GDF5 DPT FBN1 SPON1 PAPPA	6.06e-07	199	109	7	b8f3cf5bcfde1066bdb49b14fdc842fe9692a6b7
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CFH PAPPA2 DPT SPARC FBN1 SPON1 PAPPA	6.27e-07	200	109	7	0b2614b8513693dd508c9003699049efd9abac52
ToppCell	COVID-19-Fibroblasts-Pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	DPT SPARC THBS1 FBN1 TIMP2 SPON1 CCN2	6.27e-07	200	109	7	73e01b7bc43320a991c67a4fd0c04708f893c7ea
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Fibroblasts-4\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	CFH DPT SPARC FBN1 SPON1 PAPPA CCN2	6.27e-07	200	109	7	7642a14855589b0b3f68dbdc9e4d3fc7291854f7
ToppCell	Tracheal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CFH DPT SPARC FBN1 TIMP2 SPON1 PAPPA	6.27e-07	200	109	7	8ab0051544ea32eb8b3f7f8ba7582deaf8bf26c0
ToppCell	367C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	CFH DPT SPARC SLC12A8 FBN1 SPON1 TNFRSF19	6.27e-07	200	109	7	082e718c1da3f4fdd33a001d15ad3ddb2be985c7
ToppCell	proximal-mesenchymal-Adventitial_Fibroblast\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH DPT SPARC THBS1 FBN1 SPON1 CCN2	6.27e-07	200	109	7	58c5870030192b337e7d883044948634fcd17d2c
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CFH DPT SPARC FBN1 SPON1 PAPPA CCN2	6.27e-07	200	109	7	444c72334df421375ae6fc69b0adfd4950d49a43
ToppCell	proximal-mesenchymal-Adventitial_Fibroblast-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH DPT SPARC THBS1 FBN1 SPON1 CCN2	6.27e-07	200	109	7	05486d86868f6a93429226063cca270f00dd8714
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CFH PAPPA2 DPT SPARC FBN1 SPON1 PAPPA	6.27e-07	200	109	7	8d2ceb2080c67b20f452eeca605aa27a58033c04
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-4\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CFH DPT SPARC FBN1 SPON1 PAPPA CCN2	6.27e-07	200	109	7	5826c17da67bdaba3a828792279004218d8260c8
ToppCell	367C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|367C / Donor, Lineage, Cell class and subclass (all cells)	CFH DPT SPARC SLC12A8 FBN1 SPON1 TNFRSF19	6.27e-07	200	109	7	731e55070a7ff315091855bd88cda30e5a7e1a98
ToppCell	Parenchyma_Control_(B.)-Stromal-TX\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	GALNT15 CFH DPT SPARC FBN1 SPON1 CCN2	6.27e-07	200	109	7	0a86656d48e4238d0e4d592d477d29f7ba7c2ec0
ToppCell	proximal-3-mesenchymal-Adventitial_Fibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH DPT SPARC THBS1 FBN1 SPON1 CCN2	6.27e-07	200	109	7	869d45b71efd395d050873db5fee2ed0443d5e6f
ToppCell	Tracheal-10x3prime_v2-Stromal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	GALNT15 CFH DPT SPARC FBN1 TIMP2 CCN2	6.27e-07	200	109	7	f74b9b0e27afedd589e828d30194e8417029817a
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	GALNT15 CFH DPT SPARC FBN1 SPON1 CCN2	6.27e-07	200	109	7	3fa7d9ea67f9cc55478d085da53babd03dbe9bb1
ToppCell	Tracheal-10x3prime_v2-Stromal-Fibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	GALNT15 CFH DPT SPARC FBN1 TIMP2 CCN2	6.27e-07	200	109	7	5fdca7959134a5c8e06e5d6d14aafe34b963aef2
ToppCell	Lung_Parenchyma-Control-Mesenchymal\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	GALNT15 CFH DPT SPARC FBN1 SPON1 CCN2	6.27e-07	200	109	7	1e75d1302c22e1b1666c19c0c9259d5cc8be16d5
ToppCell	Parenchyma_COVID-19-Stromal-TX-Fibroblasts-2,_SCARA5\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	CFH PAPPA2 DPT SPARC FBN1 SPON1 PAPPA	6.27e-07	200	109	7	c338a08c1605527ab9aaf62ea151a19e8469dc6d
ToppCell	(5)_Fibroblast-B_(Myofibroblast)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	CFH DPT SPARC SLC12A8 FBN1 SPON1 TNFRSF19	6.27e-07	200	109	7	9bbaa666d0f3b4782c1b4b95e0fa5fc1467842d8
ToppCell	Control-Epithelial_cells-Airway_basal\|Control / group, cell type (main and fine annotations)	TRPM6 CFH ETS2 CACHD1 TNS4 MUC4	4.04e-06	171	109	6	3965ced4be6db14265a90673502fceee425837ca
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Airway_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CFH PAPPA2 DPT ULBP3 FZD9 FBN1	4.32e-06	173	109	6	b23b408acc29a667cce104429afef1a6cf2720a5
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 STIL NCAPG TNFRSF19 CCN2 CACNA2D3	4.47e-06	174	109	6	7b2f35add804981c7d588a996bdbca6ec11a1ca5
ToppCell	Substantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cbr2_(Mural.Rgs5Acta2.Cbr2)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PAPPA2 GDF15 KRT84 C1RL THBS1	4.54e-06	99	109	5	0e2f6ba2261cc289f8f4aec5aac3051f6321e041
ToppCell	Substantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cbr2_(Mural.Rgs5Acta2.Cbr2)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PAPPA2 GDF15 KRT84 C1RL THBS1	4.54e-06	99	109	5	ce9d6d9b82bdc1ebb58b0b6e04abfb022dd1de88
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	CFH DPT KERA FBN1 PAPPA CCN2	4.77e-06	176	109	6	510f9a14dc1c151d24d079e0cc004cdf4f86336c
ToppCell	wk_08-11-Mesenchymal-Chondrocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CFH PAPPA2 GDF5 DPT KERA FZD9	4.77e-06	176	109	6	1af28b701c4598ce761f85adbd5d79e4918d265a
ToppCell	10x5'v1-week_17-19-Hematopoietic-MK-early_MK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SELP CFH PGAP4 RAB40A THBS1 MED12L	5.26e-06	179	109	6	d5b9c610c1519804b1753fed1b505293ea590867
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH DPT SPARC TIMP2 SPON1 CCN2	5.43e-06	180	109	6	ea7a1ccf0dd3bb5af5df87501f873e7339a824b3
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH ABCA1 SPARC CMIP FBN1 PAPPA	5.43e-06	180	109	6	f2f6e83127a4a415e65c76a35efa8175fbd5b5d9
ToppCell	390C-Fibroblasts-Fibroblast-G\|390C / Donor, Lineage, Cell class and subclass (all cells)	CFH DPT SPARC SPON1 PAPPA CCN2	5.43e-06	180	109	6	137fc14859c89e1ecd98bee388bb58c04b835847
ToppCell	390C-Fibroblasts-Fibroblast-G-\|390C / Donor, Lineage, Cell class and subclass (all cells)	CFH DPT SPARC SPON1 PAPPA CCN2	5.43e-06	180	109	6	cd6790de050151fedfa2c5ea6ad58b72665414b2
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GALNT15 CFH SPARC HCAR1 C1RL TIMP2	5.60e-06	181	109	6	330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GALNT15 CFH SPARC HCAR1 C1RL TIMP2	5.60e-06	181	109	6	3f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	CFH DPT HIVEP3 THBS1 SPON1 MACF1	5.78e-06	182	109	6	ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GALNT15 CFH DPT SPARC FBN1 TIMP2	5.78e-06	182	109	6	e9fcae9d03a6faf85b91882c5da699037bc61aeb
ToppCell	wk_08-11-Mesenchymal-Chondrocyte-ASPN+_chondrocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CFH PAPPA2 DPT SPARC KERA FZD9	5.78e-06	182	109	6	0e52ba34e179d9bfaac7b49920b44c710b2b8dad
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CFH ETS2 THBS1 ADAMTS9 SPON1 PAPPA	5.78e-06	182	109	6	ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell	Control-Epithelial-Basal\|Control / Disease state, Lineage and Cell class	CFH LAMB3 CACHD1 DENND2C CCN2 TNS4	5.78e-06	182	109	6	caddd0a52f0234ea6a916186ffaf2454cdcd80ee
ToppCell	Adult-Epithelial-basal_cell\|Adult / Lineage, Cell type, age group and donor	CFH LAMB3 CACHD1 LRIG3 MED12L TNS4	5.97e-06	183	109	6	00a6b19ca49e3b8e0d1cd387a3515b0ff4b81c81
ToppCell	COPD-Epithelial-Basal\|COPD / Disease state, Lineage and Cell class	LAMB3 CACHD1 LRIG3 DENND2C TNS4 MUC4	5.97e-06	183	109	6	0f760e393edc91009bf6c7e02eeac039a1dfb4ed
Computational	Neighborhood of EGFR	PAPPA2 GDF15 TIMP2 PAPPA	2.45e-05	32	58	4	GNF2_EGFR
Computational	Neighborhood of IGFBP1	PAPPA2 GDF15 TIMP2 PAPPA	3.53e-05	35	58	4	GNF2_IGFBP1
Computational	Neighborhood of MMP11	PAPPA2 GDF15 TIMP2 PAPPA	7.33e-05	42	58	4	GNF2_MMP11
Computational	Neighborhood of TIMP2	PAPPA2 GDF15 TIMP2 PAPPA	1.05e-04	46	58	4	GNF2_TIMP2
Computational	Neighborhood of KISS1	PAPPA2 GDF15 TIMP2 PAPPA	1.35e-04	49	58	4	GNF2_KISS1
Computational	Genes upregulated in subsets of cells of a given type within various tumors	DPT SPARC FBN1 CCN2	1.46e-04	50	58	4	GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_1
Computational	Genes upregulated in subsets of cells of a given type within various tumors	DPT SPON1 PAPPA CACNA2D3	1.46e-04	50	58	4	GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_7
Computational	Neighborhood of RAB10	MON2 RNF14 ASAP2 MACF1 VPS13B FAM219A	3.54e-04	176	58	6	GCM_RAB10
Computational	Neighborhood of CDKN1C	PAPPA2 GDF15 TIMP2	3.98e-04	27	58	3	GNF2_CDKN1C
Disease	tumor necrosis factor receptor superfamily member 19 measurement	CFH TNFRSF19	1.23e-05	2	104	2	EFO_0020808
Disease	membranous glomerulonephritis (biomarker_via_orthology)	CFH ABCA1 SPARC	1.51e-05	14	104	3	DOID:10976 (biomarker_via_orthology)
Disease	cortical surface area measurement	MON2 TRPM6 GDF5 DAND5 SLC12A8 CACHD1 TG FZD9 NCOR1 THBS1 FBN1 ADAMTS9 ARHGAP31 MACF1 PAPPA RPS6KL1	1.91e-05	1345	104	16	EFO_0010736
Disease	Knee pain	GDF5 KIF12	3.68e-05	3	104	2	HP_0030839
Disease	leucine-rich repeats and immunoglobulin-like domains protein 3 measurement	CFH LRIG3	3.68e-05	3	104	2	EFO_0020534
Disease	macrophage-capping protein measurement	CFH NCAPG	3.68e-05	3	104	2	EFO_0020549
Disease	C-C motif chemokine 24 measurement	CFH CCL24	7.35e-05	4	104	2	EFO_0020197
Disease	scoliosis (implicated_via_orthology)	SSPOP ADAMTS9	1.22e-04	5	104	2	DOID:0060249 (implicated_via_orthology)
Disease	glucagon measurement, glucose tolerance test	SPON1 MACF1	1.83e-04	6	104	2	EFO_0004307, EFO_0008463
Disease	Age-related cataract	PGAP4 CMIP	1.83e-04	6	104	2	HP_0011141
Disease	voltage-dependent calcium channel subunit alpha-2/delta-3 measurement	CFH CACNA2D3	1.83e-04	6	104	2	EFO_0802218
Disease	clusterin measurement	CFH C1RL	2.55e-04	7	104	2	EFO_0007655
Disease	r-spondin-3 measurement	CFH C1RL	2.55e-04	7	104	2	EFO_0021878
Disease	Neurodevelopmental Disorders	MYT1L DOCK8 HIVEP3 CACNA2D3	3.34e-04	93	104	4	C1535926
Disease	Liver Cirrhosis	SPARC THBS1 FBN1 CCN2	4.93e-04	103	104	4	C0023890
Disease	X-12063 measurement	OTOGL PAPPA DMRT1 TRIM36 CACNA2D3	5.24e-04	186	104	5	EFO_0021283
Disease	Fibrosis, Liver	SPARC THBS1 FBN1 CCN2	5.30e-04	105	104	4	C0239946
Disease	otitis media (is_marker_for)	MUC5B MUC4	5.44e-04	10	104	2	DOID:10754 (is_marker_for)
Disease	f-box/LRR-repeat protein 4 measurement	CFH C1RL	5.44e-04	10	104	2	EFO_0802538
Disease	membranoproliferative glomerulonephritis (biomarker_via_orthology)	SPARC CCN2	5.44e-04	10	104	2	DOID:2920 (biomarker_via_orthology)
Disease	cortical thickness	MON2 DIP2B DAND5 SLC12A8 TG FZD9 THBS1 FBN1 ADAMTS9 MACF1 TRIM36 CACNA2D3	5.55e-04	1113	104	12	EFO_0004840
Disease	corneal topography	LRRK1 STIL FBN1 AKAP13	6.10e-04	109	104	4	EFO_0004345
Disease	colon cancer (implicated_via_orthology)	NANOGP8 NANOG	6.63e-04	11	104	2	DOID:219 (implicated_via_orthology)
Disease	brain measurement, neuroimaging measurement	GDF5 DIP2B SLC12A8 TG THBS1 ADAMTS9 MACF1 PAPPA	7.46e-04	550	104	8	EFO_0004346, EFO_0004464
Disease	sleep duration, high density lipoprotein cholesterol measurement	ABCA1 HCAR1 CMIP MACF1	9.02e-04	121	104	4	EFO_0004612, EFO_0005271
Disease	T-cell surface glycoprotein CD3 epsilon chain measurement	SELP CFH	9.36e-04	13	104	2	EFO_0802114
Disease	obesity (implicated_via_orthology)	MC3R NMUR1 ADAMTS9 SEC16A MED12L	1.00e-03	215	104	5	DOID:9970 (implicated_via_orthology)
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	ABCA1 HCAR1 CMIP SEC16A MACF1	1.23e-03	225	104	5	EFO_0008317, EFO_0020947
Disease	Germ Cell Cancer	NANOG DMRT1	1.25e-03	15	104	2	C0740345
Disease	Embryonal Neoplasm	NANOG DMRT1	1.25e-03	15	104	2	C0027654
Disease	Neoplasms, Germ Cell and Embryonal	NANOG DMRT1	1.25e-03	15	104	2	C0027658
Disease	Germ cell tumor	NANOG DMRT1	1.25e-03	15	104	2	C0205851
Disease	Neoplasms, Embryonal and Mixed	NANOG DMRT1	1.25e-03	15	104	2	C0205852
Disease	Cancer, Embryonal	NANOG DMRT1	1.25e-03	15	104	2	C0751364
Disease	Cancer, Embryonal and Mixed	NANOG DMRT1	1.25e-03	15	104	2	C0751365
Disease	free cholesterol to total lipids in medium HDL percentage	ABCA1 MADD CMIP	1.26e-03	60	104	3	EFO_0022282
Disease	pancreatic ductal carcinoma (is_marker_for)	MUC5B THBS1 MUC4	1.32e-03	61	104	3	DOID:3587 (is_marker_for)
Disease	Vertigo	SLC12A8 OTOGL MED12L TRIM36	1.51e-03	139	104	4	HP_0002321
Disease	cholangiocarcinoma (is_marker_for)	MUC5B THBS1 MUC4	1.52e-03	64	104	3	DOID:4947 (is_marker_for)
Disease	very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	ABCA1 HCAR1 CMIP SEC16A MACF1	1.60e-03	239	104	5	EFO_0008317, EFO_0020945
Disease	1-Methylhistidine measurement	KIF2B OTOGL	1.62e-03	17	104	2	EFO_0021543
Disease	total lipids in very large HDL measurement	ABCA1 MADD CMIP	1.66e-03	66	104	3	EFO_0022312
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	ABCA1 MADD CMIP MACF1	1.71e-03	144	104	4	EFO_0004611, EFO_0020943
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	ABCA1 HCAR1 MADD CMIP MACF1	1.72e-03	243	104	5	EFO_0004612, EFO_0020944
Disease	interstitial lung disease	MUC5B THSD7B AKAP13	1.73e-03	67	104	3	EFO_0004244
Disease	BMI-adjusted waist-hip ratio, physical activity measurement	GDF5 ABCA1 CMIP	1.88e-03	69	104	3	EFO_0007788, EFO_0008002
Disease	cholesterol in very large HDL measurement	ABCA1 MADD CMIP	1.88e-03	69	104	3	EFO_0022229
Disease	maximal midexpiratory flow rate	GALNT15 MED12L	2.24e-03	20	104	2	EFO_0004313
Disease	total lipids in large HDL	ABCA1 MADD CMIP	2.30e-03	74	104	3	EFO_0022189
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	ABCA1 HCAR1 CMIP SEC16A MACF1	2.47e-03	264	104	5	EFO_0008317, EFO_0020944
Disease	hemoglobin A1 measurement	GDF15 SLC12A8 MADD HIVEP3 CMIP MACF1 AKAP13	2.48e-03	520	104	7	EFO_0007629
Disease	myocardial infarction (biomarker_via_orthology)	SELP SPARC THBS1 CCN2	2.51e-03	160	104	4	DOID:5844 (biomarker_via_orthology)
Disease	Corneal astigmatism	NMUR1 MADD KCNU1	2.58e-03	77	104	3	EFO_1002040
Disease	diastolic blood pressure, systolic blood pressure	DPT DAND5 DENND2B LRIG3 CMIP FBN1 SPON1 SEC16A	2.58e-03	670	104	8	EFO_0006335, EFO_0006336
Disease	free cholesterol in large HDL measurement	ABCA1 MADD CMIP	2.77e-03	79	104	3	EFO_0022157
Disease	cholesterol in large HDL measurement	ABCA1 MADD CMIP	2.87e-03	80	104	3	EFO_0021900
Disease	chronic widespread pain	DIP2B ASAP2	2.97e-03	23	104	2	EFO_0010099
Disease	brain connectivity measurement	GDF5 STIL THBS1 SPON1 DMRT1 TRIM36	2.97e-03	400	104	6	EFO_0005210
Disease	high density lipoprotein particle size measurement	ABCA1 HCAR1 MADD CMIP	3.13e-03	170	104	4	EFO_0008592
Disease	systemic scleroderma	MYT1L CR2 ARHGAP31	3.41e-03	85	104	3	EFO_0000717
Disease	Dwarfism	SLC10A7 TG	3.50e-03	25	104	2	C0013336
Disease	medial orbital frontal cortex volume measurement	SPARC DMRT1	3.50e-03	25	104	2	EFO_0010315

Protein segments in the cluster

Peptide	Gene	Start	Entry
AMLLSPTCLPVACTG	nan	61	Q6ZRM9
MVPREAPESAQCLCP	AEN	1	Q8WTP8
IPTVISLASIMCCPE	C21orf140	146	B9A014
MADTQCCPPPCEFIS	AGPAT4-IT1	1	Q9H0P7
IIPTGSVVIPSPCCM	CCL24	21	O00175
CSSSSEMQPLPVGPC	CYSRT1	36	A8MQ03
TRCMEGNPIPDTPCQ	ABCA1	1416	O95477
MAECSTPLPEDCSPT	AKAP13	2386	Q12802
PNLIDCLMVSPACST	CMIP	426	Q8IY22
PLTAIQDCCTIPPSM	CACHD1	121	Q5VU97
LPCGPCIPIMLVLAT	C16orf54	26	Q6UWD8
PVPNSDAVLNCPACM	EAPP	171	Q56P03
ACMPTPQSLGEPTEC	DPT	76	Q07507
VNCSMAQIQLCPPPP	CFH	801	P08603
PVLPASMIDIVCCPT	DENND2B	931	P78524
MVTNLPCSVTLQPGP	ARR3	116	P36575
APITTVVTMGCEPQC	MUC5B	2861	Q9HC84
SSLCKVEIVCPPQSP	RAB40A	251	Q8WXH6
CCSERLPGLPQPIVM	PTPN5	26	P54829
SQTLGCQPMCTCPPA	MUC4	5136	Q99102
VGCMPPPVSSAVILT	SLC10A7	111	Q0GE19
GSDPTPLVLCNSCMP	DAND5	136	Q8N907
MLISEACVPSVPCPL	KRT84	556	Q9NSB2
MDPESTPPTCCVPTR	GDF5	456	P43026
PVIPLLPTCMASAEQ	MADD	351	Q8WXG6
PLPKQTCDVITCEPM	MED12L	1626	Q86YW9
MTPLCLNCSVLPGDL	NMUR1	1	Q9HB89
TPLMEQYVPCPVCET	LRRK1	1156	Q38SD2
RLSVIPTPTCDSPQM	LRIG3	781	Q6UXM1
TLMVACVSPSAQCLP	KIF12	331	Q96FN5
MECCLPAEDSVKPNP	ASAP2	501	O43150
CQPMACLPSVCLPTT	KRT32	41	Q14532
ILGCPMVLAPCSDSR	GALNT15	526	Q8N3T1
MWTTPPLCLEPCTLS	F13B	571	P05160
NIPDSPMANSGPLCC	IRF2BPL	701	Q9H1B7
CELPLLTPCSKAVMS	ETS2	66	P15036
LIPPKSVNPTCMCCQ	FAM219A	161	Q8IW50
MQLRPTEPLPSQCCG	CYB5RL	16	Q6IPT4
ILMCPHTCVTNLPKP	DIP2B	931	Q9P265
MSVDPACPQSLPCFE	NANOG	1	Q9H9S0
TACTVEMPPLSPCLS	MACF1	281	O94854
APCCVPASYNPMVLI	GDF15	271	Q99988
IEQCSMCAVLSPPPQ	KCNU1	791	A8MYU2
VVPASQCCTPAMLFP	PGAP4	326	Q9BRR3
LVVTDFLPTMPCTCL	MON2	931	Q7Z3U7
FLPTMPCTCLQIVVD	MON2	936	Q7Z3U7
SFPEALCELMCLAPP	PAPPA	1336	Q13219
PPMLCPASLNICSVV	FAAP100	391	Q0VG06
NMTVPCPTEGCSLEL	PAPPA2	941	Q9BXP8
VCSPLCVIPPSDPVM	PAPPA2	1676	Q9BXP8
TEQVSTPIPACRVMC	FZD10	96	Q9ULW2
TDQVSTPIPACRPMC	FZD9	101	O00144
TDQDCSMSPCPQRTP	ADAMTS9	1286	Q9P2N4
DCTPAIMNIVLSQPC	FBH1	651	Q8NFZ0
PSLCSPAGCMTILPT	HEATR5B	1766	Q9P2D3
CVSVFPLECPALPMI	CR2	146	P20023
PEIINCCLTPEMLPV	DOCK8	516	Q8NF50
SCLCESVAPITMAPI	CACNA2D3	1016	Q8IZS8
VPPASSQPVQTCCLL	FAM193B	71	Q96PV7
RPNMCTCPSGQIAPS	FBN1	96	P35555
LCSMDVRLPSPDCPF	CCN2	136	P29279
CPPMTSATCLLAARV	DUSP15	156	Q9H1R2
GTMLPCFCPTEQALA	CHAC1	206	Q9BUX1
LQCMPVCGRPVTPIA	C1RL	226	Q9NZP8
PVLPASMIDIVCSPT	DENND2C	726	Q68D51
SCCVPDPMGLSFLPT	DRGX	181	A6NNA5
TDSPPMCEAIKCPEL	SELP	561	P16109
MNASCCLPSVQPTLP	MC3R	1	P41968
CCRIEGDTISQVMPP	HCAR1	6	Q9BXC0
SRQMACTPISCPGEL	LAMB3	791	Q13751
CRSLVPMNTPICVVC	DZANK1	256	Q9NVP4
PMNTPICVVCEAPLA	DZANK1	261	Q9NVP4
SMCSCSLTPVPEPVL	SLC12A8	406	A0AV02
PCLMTECSGTSQPPP	DMRT1	156	Q9Y5R6
MASQFCLPESPCLSP	KIF2B	1	Q8N4N8
VCEPNLCPMPLLNCA	OTOGL	2041	Q3ZCN5
SPVCSCPQLPFMLSP	INE1	6	O15225
LSVPCPDTQDFQPCM	SPON1	476	Q9HCB6
AATAIMCDLCKPPPQ	TRIM36	151	Q9NQ86
PSELLSVPMQAFPCC	TDRD6	1621	O60522
MKTLETQPLAPDCCP	WRAP53	1	Q9BUR4
ELMFQPCAPCPLTCD	SSPOP	1816	A2VEC9
PVTCDSEMLTPDFCP	MAP3K21	826	Q5TCX8
MSVDPACPQSLPCFE	NANOGP8	1	Q6NSW7
VIPPMVSCTPCNIPI	NCOR1	936	O75376
SVNVSVICPSPSMLP	KERA	296	O60938
MACSRPPSQCEPTSL	ST6GALNAC6	1	Q969X2
AMKICNEILTSPCSP	NCAPG	831	Q9BPX3
LLIMTNNPPPCSITQ	TSGA13	96	Q96PP4
PSGPLTLQVRMSCEC	ULBP3	116	Q9BZM4
RPCCQLPVMQEPGCT	RNF14	311	Q9UBS8
NPQPCTVCMHTPKTE	STIL	696	Q15468
VSCPIMPCSNATVPD	THBS1	351	P07996
EQVLPTLSCTPEPMT	TRPM6	1421	Q9BX84
ALCLINMGTPVSSCP	MIOS	786	Q9NXC5
METLCAPQVCPLPLN	SEC16A	666	O15027
CPPSITNSMVDIPIV	TNS4	361	Q8IZW8
PMCVCQDPTSCPAPI	SPARC	91	P09486
CLPPPLIQACTMQQL	RNF44	151	Q7L0R7
DLMVLCPLCTQPPDH	TRIM75	111	A6NK02
ITRCPMIPCYISSPD	TIMP2	156	P16035
ALPACPDTMVSLVVP	HIVEP3	1306	Q5T1R4
MSLVACECLPSPGLE	RPS6KL1	1	Q9Y6S9
TCRVQSPCTPLMNPF	TMEM114	71	B3SHH9
DATAPCMCEGPTLSP	ARHGAP31	1276	Q2M1Z3
CFPTLSPFVLMSCDP	VN1R4	276	Q7Z5H5
NIVCPTAMESPCISG	ZSWIM2	521	Q8NEG5
SVQTCGPVRLLPSMC	TNFRSF19	241	Q9NS68
HLAPSCSSMQIPCPV	VPS13B	3966	Q7Z7G8
CSSMQIPCPVVAAEP	VPS13B	3971	Q7Z7G8
DEIPPETQSCSLMCP	THSD7B	1111	Q9C0I4
CPTELTQEKTCPVTP	THSD7B	1286	Q9C0I4
MRSEPSKLPTCPGSC	TG	911	P01266
CPTLIALTMFDCPVS	LRRIQ3	121	A6PVS8
CCPILTPLEPMSPQQ	MYT1L	786	Q9UL68