Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	nuclear speck	RBM14 RNF34 BAZ2A VIRMA SGK1 DDX42	2.70e-04	431	44	6	GO:0016607
Domain	AUTS2	FBRSL1 FBRS	1.55e-05	3	43	2	IPR023246
Domain	AT_hook	DOT1L BAZ2A	6.09e-04	16	43	2	PF02178
Domain	G_patch	RBM6 GPATCH8	1.27e-03	23	43	2	SM00443
Domain	G_patch_dom	RBM6 GPATCH8	1.27e-03	23	43	2	IPR000467
Domain	G-patch	RBM6 GPATCH8	1.27e-03	23	43	2	PF01585
Domain	G_PATCH	RBM6 GPATCH8	1.27e-03	23	43	2	PS50174
Domain	AT_hook	DOT1L BAZ2A	1.75e-03	27	43	2	SM00384
Domain	AT_hook_DNA-bd_motif	DOT1L BAZ2A	1.75e-03	27	43	2	IPR017956
Domain	ArfGap	AGFG1 AGFG2	2.02e-03	29	43	2	SM00105
Domain	ARFGAP	AGFG1 AGFG2	2.02e-03	29	43	2	PS50115
Domain	ArfGAP	AGFG1 AGFG2	2.02e-03	29	43	2	IPR001164
Domain	ArfGap	AGFG1 AGFG2	2.02e-03	29	43	2	PF01412
Domain	HMGI/Y_DNA-bd_CS	DOT1L BAZ2A	2.31e-03	31	43	2	IPR000637
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	RBM14 CPEB2 RBM6 AGFG2 NUP62 GPATCH8 YTHDF3 FBRS	1.18e-07	457	45	8	32344865
Pubmed	Human transcription factor protein interaction networks.	FBRSL1 RBM6 NUP62 UBAP2 GPATCH8 DOT1L PAX8 YTHDF3 ZNF746 TFRC FBRS	1.52e-06	1429	45	11	35140242
Pubmed	Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3.	AGFG1 RBM6	1.64e-06	2	45	2	9500467
Pubmed	m6A RNA modification and its writer/reader VIRMA/YTHDF3 in testicular germ cell tumors: a role in seminoma phenotype maintenance.	VIRMA YTHDF3	1.64e-06	2	45	2	30866959
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	RBM14 FBRSL1 CPEB2 RBM6 GPATCH8 VIRMA YTHDF3 DDX42	8.19e-06	807	45	8	22681889
Pubmed	Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha.	DOT1L SGK1	9.81e-06	4	45	2	17332896
Pubmed	The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport.	AGFG1 AGFG2	9.81e-06	4	45	2	10613896
Pubmed	Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization.	AGFG1 AGFG2	9.81e-06	4	45	2	9446614
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	RBM14 FBRSL1 AGFG1 RBM6 DOT1L YTHDF3 FBRS	9.91e-06	588	45	7	38580884
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	AGFG1 USP53 ZNF469 UBAP2 FAM193A RNF115	1.87e-05	430	45	6	35044719
Pubmed	Dot1a contains three nuclear localization signals and regulates the epithelial Na+ channel (ENaC) at multiple levels.	DOT1L SGK1	2.45e-05	6	45	2	20427473
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	RBM14 AGFG1 RBM6 NUP62 UBAP2 BAZ2A YTHDF3 DDX42	2.73e-05	954	45	8	36373674
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	AGFG1 UBAP2 FAM193A GPATCH8 YTHDF3 DDX42 TFRC	4.06e-05	733	45	7	34672954
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	RBM14 RBM6 VIRMA DDX42	5.03e-05	156	45	4	29961565
Pubmed	Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.	AGFG1 AGFG2	5.86e-05	9	45	2	9303539
Pubmed	Rev-ing up post-transcriptional HIV-1 RNA expression.	AGFG1 AGFG2	5.86e-05	9	45	2	21358275
Pubmed	Interaction network of human early embryonic transcription factors.	FBRSL1 YTHDF3 ZNF746 TFRC FBRS	8.93e-05	351	45	5	38297188
Pubmed	RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.	RBM14 RBM6 VIRMA DDX42	9.34e-05	183	45	4	28186131
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	RBM14 HAX1 UBAP2 DOT1L YTHDF3 DDX42 TFRC	1.00e-04	847	45	7	35850772
Pubmed	Cellular proteins and HIV-1 Rev function.	AGFG1 AGFG2	1.07e-04	12	45	2	19149558
Pubmed	Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.	PI4K2A TFRC	1.07e-04	12	45	2	19144828
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RBM14 AGFG1 USP53 NUP62 UBAP2 ATAT1 VIRMA	1.11e-04	861	45	7	36931259
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	RBM14 GPATCH8 VIRMA YTHDF3	1.24e-04	197	45	4	20811636
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LRFN2 GPATCH8 CHST15 BAZ2A VIRMA	1.78e-04	407	45	5	12693553
Pubmed	Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signaling.	FOXI2 PAX8	1.94e-04	16	45	2	21362415
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	RBM6 NUP62 UBAP2 GPATCH8 FBRS	2.55e-04	440	45	5	34244565
Pubmed	Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode.	FOXI2 PAX8	3.06e-04	20	45	2	18495817
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	RBM14 CPEB2 HAX1 FAM193A YTHDF3	3.19e-04	462	45	5	31138677
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	FBRSL1 AGFG1 AGFG2 HAX1 DYNC2I2 YTHDF3 FBRS	3.48e-04	1038	45	7	26673895
Pubmed	TIM-1 Ubiquitination Mediates Dengue Virus Entry.	PI4K2A TFRC	4.07e-04	23	45	2	29742433
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	RBM14 RBM6 UBAP2 YTHDF3 TFRC	4.33e-04	494	45	5	26831064
Pubmed	The mouse Foxi3 transcription factor is necessary for the development of posterior placodes.	FOXI2 PAX8	4.44e-04	24	45	2	26550799
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	FAM184B GPATCH8 DOT1L NRDC YTHDF3 DDX42 FBRS	4.52e-04	1084	45	7	11544199
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RBM14 PI4K2A RBM6 GPATCH8 BAZ2A VIRMA	4.63e-04	774	45	6	15302935
Pubmed	Wnt signals mediate a fate decision between otic placode and epidermis.	FOXI2 PAX8	4.82e-04	25	45	2	16452098
Pubmed	Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors.	DOT1L BAZ2A	6.50e-04	29	45	2	24105743
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	PI4K2A NUP62 HAX1 UBAP2 NRDC	7.63e-04	560	45	5	35241646
Pubmed	An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells.	AGFG1 TFRC	7.92e-04	32	45	2	28388416
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	FBRSL1 AGFG1 HAX1 FAM193A	7.97e-04	322	45	4	39098523
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	UBAP2 GPATCH8 VIRMA ABHD16A DDX42 TFRC FBRS	8.37e-04	1203	45	7	29180619
Pubmed	Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases.	RBM14 NUP62	8.94e-04	34	45	2	16611982
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	RBM14 FBRSL1 FBRS	1.02e-03	152	45	3	38360978
Pubmed	An AUTS2-Polycomb complex activates gene expression in the CNS.	RBM14 FBRS	1.12e-03	38	45	2	25519132
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	AGFG1 NUP62 UBAP2 FAM193A BAZ2A DDX42	1.23e-03	934	45	6	33916271
Interaction	TLE3 interactions	RBM14 FBRSL1 AGFG2 FAM193A GPATCH8 DOT1L PAX8 VIRMA FBRS	9.92e-08	376	44	9	int:TLE3
Interaction	CPEB4 interactions	RBM14 CPEB2 UBAP2 FAM193A VIRMA YTHDF3	1.08e-06	156	44	6	int:CPEB4
Interaction	NUP35 interactions	RBM14 CPEB2 RBM6 AGFG2 NUP62 GPATCH8 YTHDF3 FBRS	3.28e-06	424	44	8	int:NUP35
Interaction	YTHDF3 interactions	UBAP2 FAM193A DOT1L VIRMA YTHDF3 TFRC	1.49e-05	246	44	6	int:YTHDF3
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	RBM6 GPATCH8	6.02e-04	22	30	2	579
GeneFamily	ArfGAPs	AGFG1 AGFG2	1.36e-03	33	30	2	395
GeneFamily	RNA binding motif containing	RBM14 CPEB2 RBM6	5.18e-03	213	30	3	725
ToppCell	facs-Trachea-18m-Hematologic-myeloid-granulocyte-granulocyte_l8\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CSF2RB CHST15 SELENON FBRS	1.74e-05	157	44	4	5098675f64342c41c5ca3551b24962d10c83e64d
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Necab1_(MGE-derived_cortical_interneurons--basket_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	DUOX1 PAX8 FER1L4	2.21e-05	55	44	3	ed871246b0ada07e8fe87a68584c06986977d0bd
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Necab1_(MGE-derived_cortical_interneurons--basket_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	DUOX1 PAX8 FER1L4	2.21e-05	55	44	3	51a76e6cb45976ce99a41fb6cd5b94c632ec7c5b
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-Exhausted_Tfh\|T/NK_cells / Location, Cell class and cell subclass	FBRSL1 AGFG1 SGK1 YTHDF3	2.32e-05	169	44	4	625788d86f0ceebcf2653a251db1f1a9f9746d29
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBRSL1 USP53 UBAP2 SLC12A9	2.48e-05	172	44	4	8a6a2b4c6654bc976e60a02d0e7303a9071ed55f
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	AGFG1 CSF2RB CHST15 SGK1	4.30e-05	198	44	4	a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NUP62 CHST15 SLC12A9 FBRS	4.39e-05	199	44	4	bbb4798d6a24e756fea744a151ba67c1bafbac9a
Disease	congenital hypothyroidism (implicated_via_orthology)	DUOX1 PAX8	1.87e-04	14	43	2	DOID:0050328 (implicated_via_orthology)
Disease	non-high density lipoprotein cholesterol measurement	FBRSL1 AGFG1 HAX1 LRFN2 ATAT1 NRDC	5.55e-04	713	43	6	EFO_0005689
Disease	urate measurement, bone density	FBRSL1 RBM6 ATG9B CSF2RB SELENON	1.99e-03	619	43	5	EFO_0003923, EFO_0004531
Disease	PROSTATE CANCER, HEREDITARY, 1	FBRSL1 ATAT1	3.48e-03	60	43	2	C4722327
Disease	osteoarthritis	RBM6 DOT1L XKR4	4.15e-03	222	43	3	MONDO_0005178
Disease	Prostate cancer, familial	FBRSL1 ATAT1	4.57e-03	69	43	2	C2931456
Disease	axial length measurement	ZNF469 DYNC2I2	5.66e-03	77	43	2	EFO_0005318
Disease	mean reticulocyte volume	FBRSL1 RBM6 AGFG2 ZNF469 TFRC	5.91e-03	799	43	5	EFO_0010701

Protein segments in the cluster

Peptide	Gene	Start	Entry
FPSTGAAHPASNPFG	FBRSL1	651	Q9HCM7
NDHFNFTGLPPAPAA	BAZ2A	6	Q9UIF9
PGAAPFGNFPHYSRF	BCDIN3D	26	Q7Z5W3
NHPGFAGSTGVPFPQ	ABHD16A	311	O95870
HRSFLGPFPPGPQFA	DOT1L	1461	Q8TEK3
FFGHGGPPAAPTSRN	FAM193A	796	P78312
SGQGIFSFRPSPNGH	RNF212B	231	A8MTL3
GGFDGQARQPTPPFF	RBM14	196	Q96PK6
GSGVPPFNAFPHAAS	PAX8	336	Q06710
THFGRPPFEPFFNSL	DUOX1	1491	Q9NRD9
FGFPGPRSHRDPFFG	HAX1	11	O00165
FHSPQHPPEEFGFGF	HAX1	51	O00165
GAFYPLPRNHNGPGF	MGAM2	626	Q2M2H8
NRSFSFNPHPGYLTP	FAM184B	946	Q9ULE4
ISHPGRAAGFNPTFG	FER1L4	291	A9Z1Z3
RAPAQFTFSPHGGPI	DYNC2I2	381	Q96EX3
PGFAPGHQTAAAGFR	FOXI2	291	Q6ZQN5
AAPPRPGSSFAHFGF	DDX42	246	Q86XP3
PPGSSDALFGHQFPS	GPATCH8	1181	Q9UKJ3
GFNFGAPFQPATSTP	NUP62	41	P37198
PDYTFPSGSGAHFPQ	PI4K2A	16	Q9BTU6
TGAFPIQPFVPHGFQ	ERVK-19	621	Q9YNA8
ANPFTAAPGAHGPFL	FBRS	151	Q9HAH7
SFDFNGPYLGPPHSR	CSF2RB	586	P32927
NPAFFPSFSPVSPHG	CPEB2	21	Q7Z5Q1
LFANQPSNHTRPGPF	ATG9B	241	Q674R7
FEGFFAHQHRPPAPS	ATAT1	186	Q5SQI0
DSLPFDFQGHSGPPF	RBM6	51	P78332
GFFANSAIPGSPHPF	RNF115	151	Q9Y4L5
PFNPNVSGPNDLRHF	SGK1	371	O00141
PGFPSFNHTQFPPSR	TFRC	311	P02786
GGFPTASHSPFQPQT	AGFG1	256	P52594
PAFAAFPAFGGQTPS	AGFG2	241	O95081
LISSPFHYGGFPSNP	CHST15	106	Q7LFX5
SHFQSGSPPAPNGFK	USP53	486	Q70EK8
PPFLGQHGFNFFPGN	YTHDF3	116	Q7Z739
FDKQGFHAGTPPPFS	UBAP2	1026	Q5T6F2
AFAGATGPFRFTPNP	RNF34	31	Q969K3
GPNGSSLPPRFGHFT	SLC12A9	226	Q9BXP2
FATRHFQPFLPPPGQ	SELENON	201	Q9NZV5
AFFHPNGPRFGQSPS	XKR4	511	Q5GH76
NGLPRPNFGHLTDPF	NRDC	406	O43847
PFSPRGANFHFQPVQ	ZNF469	1656	Q96JG9
FGPGQATRFFPSPAQ	ZNF746	311	Q6NUN9
GRGAFHSQNRFFTPP	VIRMA	1696	Q69YN4
FAPPLSFSFGGNPLH	LRFN2	231	Q9ULH4