Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

TRPC1 ITPR3

1.36e-0414252GO:0070679
GeneOntologyMolecularFunctionphosphatidylinositol phospholipase C activity

PLCD3 PLCB2

4.80e-0426252GO:0004435
GeneOntologyMolecularFunctionphospholipase C activity

PLCD3 PLCB2

5.98e-0429252GO:0004629
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol

PLCB2 TRPC1 ITPR3 CEMIP

2.71e-05146254GO:0051209
GeneOntologyBiologicalProcessnegative regulation of sequestering of calcium ion

PLCB2 TRPC1 ITPR3 CEMIP

2.79e-05147254GO:0051283
GeneOntologyBiologicalProcessregulation of sequestering of calcium ion

PLCB2 TRPC1 ITPR3 CEMIP

2.94e-05149254GO:0051282
GeneOntologyBiologicalProcesssequestering of calcium ion

PLCB2 TRPC1 ITPR3 CEMIP

3.26e-05153254GO:0051208
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

PLCB2 TRPC1 ITPR3 CEMIP

1.27e-04217254GO:0097553
GeneOntologyBiologicalProcessmaintenance of location in cell

PLCB2 TRPC1 ITPR3 CEMIP

2.50e-04259254GO:0051651
DomainPIPLC_Y_DOMAIN

PLCD3 PLCB2

1.64e-0415242PS50008
DomainPI-PLC_fam

PLCD3 PLCB2

1.64e-0415242IPR001192
DomainPLC_EF-hand-like

PLCD3 PLCB2

1.64e-0415242IPR015359
DomainPI-PLC-Y

PLCD3 PLCB2

1.64e-0415242PF00387
DomainPLipase_C_Pinositol-sp_Y

PLCD3 PLCB2

1.64e-0415242IPR001711
DomainEF-hand_like

PLCD3 PLCB2

1.64e-0415242PF09279
DomainPLCYc

PLCD3 PLCB2

1.64e-0415242SM00149
DomainPI-PLC-X

PLCD3 PLCB2

2.39e-0418242PF00388
DomainPLCXc

PLCD3 PLCB2

2.39e-0418242SM00148
DomainPIPLC_X_DOMAIN

PLCD3 PLCB2

2.67e-0419242PS50007
DomainPLipase_C_PInositol-sp_X_dom

PLCD3 PLCB2

2.67e-0419242IPR000909
Domain-

PLCD3 PLCB2

4.66e-04252423.20.20.190
DomainPLC-like_Pdiesterase_TIM-brl

PLCD3 PLCB2

4.66e-0425242IPR017946
DomainIon_trans_dom

TRPC1 ITPR3

9.34e-03114242IPR005821
DomainIon_trans

TRPC1 ITPR3

9.34e-03114242PF00520
DomainC2

PLCD3 PLCB2

1.22e-02131242PF00168
DomainC2

PLCD3 PLCB2

1.33e-02137242SM00239
PathwayWP_GPR40_PATHWAY

PLCD3 PLCB2 ITPR3

9.35e-0715193M39526
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

PLCD3 ITPR3

2.57e-056192M47960
PathwayWP_PHOSPHOINOSITIDES_METABOLISM

PLCD3 PLCB2 SBF2

3.68e-0549193M40046
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

PLCB2 ITPR3

7.70e-0510192M47661
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

PLCD3 PLCB2 TRPC1 ITPR3

8.21e-05178194M2890
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

PLCB2 ITPR3

9.40e-0511192M49033
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

PLCB2 ITPR3

1.33e-0413192M47656
PathwayKEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM

PLCD3 PLCB2 ITPR3

1.37e-0476193M9052
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

PLCB2 ITPR3

3.22e-0420192M47688
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

PLCB2 ITPR3

3.56e-0421192M47689
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

PLCB2 ITPR3

3.91e-0422192M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

PLCB2 ITPR3

3.91e-0422192M47675
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

PLCB2 ITPR3

4.28e-0423192M47676
PathwayREACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL

PLCD3 PLCB2

5.49e-0426192M27053
PathwayREACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL

PLCD3 PLCB2

6.37e-0428192MM14711
PathwayWP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION

PLCD3 PLCB2

8.86e-0433192M39745
PathwayWP_RENINANGIOTENSINALDOSTERONE_SYSTEM_RAAS

PLCB2 ITPR3

1.57e-0344192M39845
PathwaySIG_BCR_SIGNALING_PATHWAY

CR2 ITPR3

1.72e-0346192M8626
PathwayWP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY

PLCD3 PLCB2

1.72e-0346192M48317
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

PLCB2 ITPR3

1.79e-0347192M42524
PathwayREACTOME_INOSITOL_PHOSPHATE_METABOLISM

PLCD3 PLCB2

1.87e-0348192MM14589
PathwayREACTOME_INOSITOL_PHOSPHATE_METABOLISM

PLCD3 PLCB2

1.87e-0348192M26964
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

PLCB2 ITPR3

2.03e-0350192M47951
PathwayKEGG_TASTE_TRANSDUCTION

PLCB2 ITPR3

2.19e-0352192M5785
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

TRPC1 ITPR3

2.28e-0353192MM15716
PathwayKEGG_INOSITOL_PHOSPHATE_METABOLISM

PLCD3 PLCB2

2.36e-0354192M3896
PathwayREACTOME_ION_HOMEOSTASIS

TRPC1 ITPR3

2.36e-0354192MM15202
PathwayREACTOME_ION_HOMEOSTASIS

TRPC1 ITPR3

2.36e-0354192M27460
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

PLCB2 ITPR3

2.36e-0354192M26911
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

PLCB2 ITPR3

3.00e-0361192MM15071
PathwayREACTOME_CA2_PATHWAY

PLCB2 ITPR3

3.10e-0362192M27321
PathwayKEGG_LONG_TERM_POTENTIATION

PLCB2 ITPR3

3.94e-0370192M3115
PathwayKEGG_LONG_TERM_DEPRESSION

PLCB2 ITPR3

3.94e-0370192M8232
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

PLCB2 ITPR3

4.16e-0372192MM14631
PathwayWP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY

TRPC1 ITPR3

4.39e-0374192M48080
PathwayWP_ALZHEIMERS_DISEASE

PLCB2 ITPR3

4.39e-0374192MM15962
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

PLCB2 ITPR3

4.86e-0378192M1921
Pubmed

Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx.

PLCB2 TRPC1 ITPR3

2.75e-08925315623527
Pubmed

Expression of truncated transient receptor potential protein 1alpha (Trp1alpha ): evidence that the Trp1 C terminus modulates store-operated Ca2+ entry.

TRPC1 ITPR3

1.49e-06325210980191
Pubmed

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells.

TRPC1 ITPR3

2.97e-06425219052258
Pubmed

Expression of Six1 and Six4 in mouse taste buds.

PLCB2 ITPR3

7.43e-06625220668922
Pubmed

Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells.

TRPC1 ITPR3

7.43e-06625217416589
Pubmed

Association between common variation in genes encoding sweet taste signaling components and human sucrose perception.

PLCB2 ITPR3

1.39e-05825220660057
Pubmed

Marginal zone SIGN-R1+ macrophages are essential for the maturation of germinal center B cells in the spleen.

CLEC4M CR2

1.78e-05925232424104
Pubmed

Combined in silico and in vivo analyses reveal role of Hes1 in taste cell differentiation.

PLCB2 ITPR3

1.78e-05925219343206
Pubmed

Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels.

TRPC1 ITPR3

1.78e-05925211290752
Pubmed

Expression of phospholipase C isozymes by murine B lymphocytes.

PLCD3 PLCB2

2.22e-05102522033248
Pubmed

Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.

PLCB2 ITPR3

3.26e-051225232294408
Pubmed

Ascl3 transcription factor marks a distinct progenitor lineage for non-neuronal support cells in the olfactory epithelium.

PLCB2 ITPR3

4.49e-051425227910949
Pubmed

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.

PLCB2 ITPR3

5.18e-051525228578927
Pubmed

Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium.

PLCB2 ITPR3

5.18e-051525224428937
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

CR2 TRPC1 ITPR3

5.22e-0510125323382219
Pubmed

Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.

PLCD3 PLCB2

7.54e-05182521979339
Pubmed

Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.

PLCB2 TRPC1

1.03e-042125230270038
Pubmed

The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity.

KRT82 ITPR3

1.14e-042225211696558
Pubmed

Gene network analysis in a pediatric cohort identifies novel lung function genes.

CERKL SAMD4A

1.36e-042425224023788
Pubmed

Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.

PLCB2 ITPR3

1.36e-042425210843712
Pubmed

Genetic mapping of the human and mouse phospholipase C genes.

PLCD3 PLCB2

2.58e-04332528672127
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

TRPC1 ITPR3

3.43e-043825230786075
InteractionTRPC3 interactions

NAPA PLCB2 TRPC1 ITPR3

7.35e-0833254int:TRPC3
Cytoband7q36.1

SSPOP ZNF786

7.51e-04742527q36.1
CytobandEnsembl 112 genes in cytogenetic band chr7q36

SSPOP ZNF786

3.39e-03159252chr7q36
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCD3 PLCB2

9.45e-0519142832
GeneFamilyPhospholipases

PLCD3 PLCB2

4.71e-0442142467
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP2 SSPOP CEMIP

6.05e-051372534dcb15de821439011df1bb0bbd7682d674bd725d
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLGAP2 SSPOP CEMIP

6.05e-05137253c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CERKL PLCB2 UPB1

9.58e-05160253cfd005e98944817458e8ef9e0c436d77f50c1ad1
ToppCellfacs-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l15|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CERKL PLCB2 UPB1

1.01e-04163253f558ad9569e5137e62a601ba4f073e69ed8f8650
ToppCellfacs-Kidney-nan-24m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GSTZ1 UPB1 PZP

1.05e-0416525302a09d0918b103aca21c36b42c5a8a8ebad8686c
ToppCellfacs-Kidney-nan-24m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GSTZ1 UPB1 PZP

1.05e-04165253906321cb5f299d77436fb5540fd8c52d7532beca
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-Lymphoid_DC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CERKL DLGAP2 UPB1

1.11e-041682536dd58fd981750da49afd53796f244e1803cce97f
ToppCellImmune_cells-B_cell|Immune_cells / Lineage and Cell class

CR2 CTSO ITPR3

1.19e-04172253b646894b691a99bf2742bd9da8e578dff0e87f1f
ToppCellmetastatic_Lymph_Node-Endothelial_cells-Lymphatic_ECs|metastatic_Lymph_Node / Location, Cell class and cell subclass

DLGAP2 CLEC4M CEMIP

1.23e-04174253d551bc29afef071adf4c9bb80345352ec33441d8
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CLEC4M CR2 CEMIP

1.29e-04177253d6596a0b6fd146fefc27717c1a7dbaa3774cc644
ToppCellmetastatic_Lymph_Node-Endothelial_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

DLGAP2 CLEC4M CEMIP

1.29e-0417725371bf5d4bc67bda37a0499e5ec01af7dd5254041d
ToppCellTCGA-Liver-Solid_Tissue_Normal-Liver-Liver_normal_tissue|TCGA-Liver / Sample_Type by Project: Shred V9

GSTZ1 CLEC4M PZP

1.34e-0417925317ba1eedb6ebf039d3b11d099351d0ac6363c8d1
ToppCellTCGA-Liver-Solid_Tissue_Normal|TCGA-Liver / Sample_Type by Project: Shred V9

GSTZ1 CLEC4M PZP

1.34e-041792537046f0a426e45fe1b41a25721ee1e33f6fc7f9e3
ToppCellTCGA-Liver-Solid_Tissue_Normal-Liver|TCGA-Liver / Sample_Type by Project: Shred V9

GSTZ1 CLEC4M PZP

1.34e-041792530e22e840f43ca81a7543dcf33ec17a741cdf7f37
ToppCellTCGA-Liver-Solid_Tissue_Normal-Liver-Liver_normal_tissue-2|TCGA-Liver / Sample_Type by Project: Shred V9

GSTZ1 CLEC4M PZP

1.34e-04179253a20bb3ace5be10c5aef330e9268c0ba55f8fee23
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CLEC4M CR2 CEMIP

1.40e-04182253f231e86524b628e6e11ac33d5c34be99d454a92a
Drug3-F-InsP3

TRPC1 ITPR3

2.42e-057252CID003035756
DrugSpiramycin [8025-81-8]; Down 200; 4.8uM; MCF7; HT_HG-U133A

TADA2A FAM120C TRPC1 SAMD4A

5.62e-051942543938_DN
DrugGemfibrozil [25812-30-0]; Up 200; 16uM; MCF7; HT_HG-U133A

TADA2A FAM120C SAMD4A CEMIP

5.85e-051962545488_UP
DrugSotalol hydrochloride [959-24-0]; Up 200; 13uM; MCF7; HT_HG-U133A

N4BP2L2 TADA2A FAM120C TRPC1

5.85e-051962547338_UP
DrugCinnarizine [298-57-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A

UPB1 CTSO SAMD4A CEMIP

5.85e-051962543175_UP
DrugCephalexin monohydrate [23325-78-2]; Up 200; 11uM; PC3; HT_HG-U133A

DLGAP2 UPB1 SAMD4A ITPR3

5.96e-051972544654_UP
DrugCaffeic acid [3331-39-5]; Up 200; 22.2uM; MCF7; HT_HG-U133A

TADA2A FAM120C TRPC1 SAMD4A

6.08e-051982545352_UP
Drug1-aminoindan

GSTZ1 PLCB2 KRT82

7.20e-0574253CID000123445
Diseaseblood copper measurement

KRT82 ITPR3

5.79e-0450212EFO_0007578
Diseasehypertension

PLCD3 PLCB2 SBF2

1.29e-03307213EFO_0000537
Diseaseresponse to tenofovir, creatinine clearance measurement

DLGAP2 PZP

2.86e-03112212EFO_0007934, EFO_0009279
Diseasemyeloid white cell count

PLCB2 TADA2A CLEC4M SBF2

3.93e-03937214EFO_0007988
Diseaseautism spectrum disorder (implicated_via_orthology)

TRPC1 ITPR3

5.19e-03152212DOID:0060041 (implicated_via_orthology)
Diseasecardiac troponin I measurement

DLGAP2 PZP

6.90e-03176212EFO_0010071
Diseaseobesity (implicated_via_orthology)

PLCB2 ITPR3

1.01e-02215212DOID:9970 (implicated_via_orthology)
Diseaseresponse to paliperidone, schizophrenia symptom severity measurement

DLGAP2 SAMD4A

1.02e-02216212EFO_0007925, EFO_0007927
Diseaseneutrophil count, basophil count

CLEC4M ZNF786

1.10e-02224212EFO_0004833, EFO_0005090
Diseasechronic kidney disease

DLGAP2 PLCB2

1.20e-02235212EFO_0003884

Protein segments in the cluster

PeptideGeneStartEntry
SIWKNNCMTTNQTNG

CXorf66

11

Q5JRM2
MSQKFQQFYWLCQQN

DLGAP2

916

Q9P1A6
STFWMANPNNNLINC

CEMIP

671

Q8WUJ3
QSLTWLSQMQKDNGC

PZP

1071

P20742
NSVNCNTSWKINLFM

ITPR3

211

Q14573
NFCAQDGQSAQQWMD

SBF2

1826

Q86WG5
DGQSAQQWMDKIQSC

SBF2

1831

Q86WG5
SSAAAWQAMQNGGKN

PNRC2

51

Q9NPJ4
WQAMQNGGKNKNFPN

PNRC2

56

Q9NPJ4
TQSGMNLEWSQKCLQ

NXF1

576

Q9UBU9
KWNFMQQQRCCQTNI

KRT82

151

Q9NSB4
NFSMNGNKSVWCQAN

CR2

121

P20023
LCQQVNDVWNFKMTG

UPB1

346

Q9UBR1
SWNGKNLTTNQFLMQ

FAM120C

281

Q9NX05
KSDCNDQWQMIQGQF

CERKL

411

Q49MI3
MQLTWAQNAITCGFN

GSTZ1

126

O43708
CFAMWQCQLQAGSAN

SSPOP

116

A2VEC9
GFGNWQDVANQMCTK

TADA2A

91

O75478
KNWSAAGNAFCQAAQ

NAPA

56

P54920
TQVRNQQMCGGCWAF

CTSO

121

P43234
QGNCYFMSNSQRNWH

CLEC4M

276

Q9H2X3
NCQQFLNTVWFGQMS

TRPC1

326

P48995
EMWNSGCQLVALNFQ

PLCD3

601

Q8N3E9
WNAGCQMVALNFQTM

PLCB2

621

Q00722
QLFWGSQQAMNSGKT

ZNF786

96

Q8N393
NASNWQDKSMGCENG

SAMD4A

201

Q9UPU9
NCHVNWNCMTFDQNN

N4BP2L2

321

Q92802