Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionenzyme regulator activity

DOCK3 RALGAPA1 RGPD2 RALGDS CPAMD8 PSD PPP2R2D RPS6KA3 PPP2R3B CASP3 DENND1A TBC1D9 TBC1D20 PPP2R2B PPP2R2C KIDINS220 SERPINI2 TBC1D22A SERPINE1 DENND6B PINX1 SPDYA SERPINC1 AKAP11 BCAR3 SIPA1L2 SMCR8 SERPINA7 PLCE1

5.60e-06141816629GO:0030234
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH3 DNAH1 DNAH9 DYNC1H1

1.29e-05181664GO:0008569
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH3 DNAH1 DNAH9 DYNC1H1

8.07e-05281664GO:0051959
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

DOCK3 RALGAPA1 RGPD2 RALGDS PSD DENND1A TBC1D9 TBC1D20 TBC1D22A DENND6B BCAR3 SIPA1L2 SMCR8 PLCE1

8.99e-0550716614GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

DOCK3 RALGAPA1 RGPD2 RALGDS PSD DENND1A TBC1D9 TBC1D20 TBC1D22A DENND6B BCAR3 SIPA1L2 SMCR8 PLCE1

8.99e-0550716614GO:0030695
GeneOntologyMolecularFunctioncalcium channel activity

TRPC3 TRPM2 PKD2L1 GRIN2A PKDREJ RYR3 CNGB1

1.03e-041291667GO:0005262
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH3 DNAH1 DNAH9 DYNC1H1

2.46e-04371664GO:0045505
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

TRPC3 TRPM2 PKD2L1 GRIN2A PKDREJ RYR3 CNGB1

2.74e-041511667GO:0015085
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

DOCK3 RALGDS PSD DENND1A DENND6B BCAR3 SMCR8 PLCE1

7.16e-042311668GO:0005085
GeneOntologyBiologicalProcessmast cell differentiation

ITGAM STAT5A PIK3CD

2.73e-0581653GO:0060374
GeneOntologyBiologicalProcessolfactory nerve development

PLXNA3 CNGB1 PLXNA1

2.73e-0581653GO:0021553
GeneOntologyBiologicalProcessmyeloid cell apoptotic process

ITGAM STAT5A STAT5B KITLG PIK3CD

5.38e-05511655GO:0033028
GeneOntologyBiologicalProcessolfactory nerve formation

PLXNA3 PLXNA1

6.36e-0521652GO:0021628
GeneOntologyCellularComponentprotein phosphatase type 2A complex

PPP2R2D PPP2R3B PPP2R2B PPP2R2C

1.08e-05181664GO:0000159
GeneOntologyCellularComponentendoplasmic reticulum-Golgi intermediate compartment membrane

TMED1 COPZ2 TMED5 TRIP11 TBC1D20 MPPE1

4.54e-05811666GO:0033116
DomainPP2A_PR55_CS

PPP2R2D PPP2R2B PPP2R2C

2.50e-0641613IPR018067
DomainPP2A_PR55

PPP2R2D PPP2R2B PPP2R2C

2.50e-0641613IPR000009
DomainPR55_2

PPP2R2D PPP2R2B PPP2R2C

2.50e-0641613PS01025
DomainPR55_1

PPP2R2D PPP2R2B PPP2R2C

2.50e-0641613PS01024
DomainDynein_heavy_chain_D4_dom

DNAH3 DNAH1 DNAH9 DYNC1H1

4.98e-06141614IPR024317
DomainDynein_HC_stalk

DNAH3 DNAH1 DNAH9 DYNC1H1

4.98e-06141614IPR024743
DomainDynein_heavy_dom-2

DNAH3 DNAH1 DNAH9 DYNC1H1

4.98e-06141614IPR013602
DomainDHC_N2

DNAH3 DNAH1 DNAH9 DYNC1H1

4.98e-06141614PF08393
DomainATPase_dyneun-rel_AAA

DNAH3 DNAH1 DNAH9 DYNC1H1

4.98e-06141614IPR011704
DomainMT

DNAH3 DNAH1 DNAH9 DYNC1H1

4.98e-06141614PF12777
DomainAAA_8

DNAH3 DNAH1 DNAH9 DYNC1H1

4.98e-06141614PF12780
DomainAAA_5

DNAH3 DNAH1 DNAH9 DYNC1H1

4.98e-06141614PF07728
DomainDHC_fam

DNAH3 DNAH1 DNAH9 DYNC1H1

6.74e-06151614IPR026983
DomainDynein_heavy

DNAH3 DNAH1 DNAH9 DYNC1H1

6.74e-06151614PF03028
DomainDynein_heavy_dom

DNAH3 DNAH1 DNAH9 DYNC1H1

6.74e-06151614IPR004273
DomainTMED5

TMED1 TMED5

7.39e-0521612IPR015717
DomainSerpin_CS

SERPINI2 SERPINE1 SERPINC1 SERPINA7

1.58e-04321614IPR023795
DomainSerpin_dom

SERPINI2 SERPINE1 SERPINC1 SERPINA7

2.53e-04361614IPR023796
DomainSERPIN

SERPINI2 SERPINE1 SERPINC1 SERPINA7

2.81e-04371614PS00284
DomainSERPIN

SERPINI2 SERPINE1 SERPINC1 SERPINA7

2.81e-04371614SM00093
DomainSerpin

SERPINI2 SERPINE1 SERPINC1 SERPINA7

3.12e-04381614PF00079
DomainSerpin_fam

SERPINI2 SERPINE1 SERPINC1 SERPINA7

3.46e-04391614IPR000215
Domain-

PPP2R3B PKD2L1 TBC1D9 RYR3 STAT5A STAT5B S100A13 PLCB2 PLCE1

4.46e-0426116191.10.238.10
Domain-

MLH3 SACS TOP2A

6.43e-042016133.30.565.10
DomainDNA_mismatch_repair_CS

SLC25A42 MLH3

7.26e-0451612IPR014762
DomainPKD_2

PKD2L1 PKDREJ

7.26e-0451612IPR003915
DomainHATPase_C

MLH3 SACS TOP2A

7.46e-04211613IPR003594
DomainEF-hand-dom_pair

PPP2R3B PKD2L1 TBC1D9 RYR3 STAT5A STAT5B S100A13 PLCB2 PLCE1

8.79e-042871619IPR011992
Domainp53-like_TF_DNA-bd

STAT5A STAT5B TBX10 TBX1

1.12e-03531614IPR008967
DomainVWA

COL12A1 ITGAM ITGAX COCH

1.38e-03561614PF00092
DomainRASGEF

RALGDS BCAR3 PLCE1

1.41e-03261613PS00720
DomainSTAT_TF_DNA-bd_sub

STAT5A STAT5B

1.51e-0371612IPR012345
DomainSTAT

STAT5A STAT5B

1.51e-0371612IPR001217
DomainSTAT_int

STAT5A STAT5B

1.51e-0371612SM00964
DomainSTAT_TF_DNA-bd

STAT5A STAT5B

1.51e-0371612IPR013801
DomainSTAT_bind

STAT5A STAT5B

1.51e-0371612PF02864
DomainSTAT_int

STAT5A STAT5B

1.51e-0371612PF02865
Domain-

STAT5A STAT5B

1.51e-03716121.10.532.10
DomainSTAT_alpha

STAT5A STAT5B

1.51e-0371612PF01017
DomainTRPC_channel

TRPC3 TRPM2

1.51e-0371612IPR002153
Domain-

STAT5A STAT5B

1.51e-03716121.20.1050.20
DomainSTAT_TF_prot_interaction

STAT5A STAT5B

1.51e-0371612IPR013799
DomainSTAT_TF_coiled-coil

STAT5A STAT5B

1.51e-0371612IPR015988
Domain-

STAT5A STAT5B

1.51e-03716122.60.40.630
DomainRASGEF_CAT

RALGDS BCAR3 PLCE1

1.95e-03291613PS50009
DomainSTAT_TF_alpha

STAT5A STAT5B

2.00e-0381612IPR013800
DomainDHC_N1

DNAH9 DYNC1H1

2.00e-0381612PF08385
DomainTMP21-related

TMED1 TMED5

2.00e-0381612IPR015720
DomainDynein_heavy_dom-1

DNAH9 DYNC1H1

2.00e-0381612IPR013594
DomainRasGEF

RALGDS BCAR3 PLCE1

2.15e-03301613PF00617
Domain-

RALGDS BCAR3 PLCE1

2.15e-033016131.10.840.10
DomainRASGEF_cat_dom

RALGDS BCAR3 PLCE1

2.15e-03301613IPR001895
DomainRasGEF

RALGDS BCAR3 PLCE1

2.15e-03301613SM00147
DomainRas_GEF_dom

RALGDS BCAR3 PLCE1

2.15e-03301613IPR023578
DomainSemap_dom

PLXNA3 SEMA4G PLXNA1

2.37e-03311613IPR001627
DomainSEMA

PLXNA3 SEMA4G PLXNA1

2.37e-03311613PS51004
DomainSema

PLXNA3 SEMA4G PLXNA1

2.37e-03311613SM00630
DomainSema

PLXNA3 SEMA4G PLXNA1

2.37e-03311613PF01403
DomainPlexin_cytopl

PLXNA3 PLXNA1

2.55e-0391612PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNA3 PLXNA1

2.55e-0391612IPR013548
DomainPlexin

PLXNA3 PLXNA1

2.55e-0391612IPR031148
DomainEMP24_GP25L

TMED1 TMED5

2.55e-0391612SM01190
DomainPlexin_repeat

PLXNA3 SEMA4G PLXNA1

2.60e-03321613IPR002165
DomainPSI

PLXNA3 SEMA4G PLXNA1

2.60e-03321613PF01437
DomainARM-type_fold

DOCK3 RALGAPA1 ATR CWC22 ARMCX1 RYR3 PIK3CD CLTC XPO7

2.75e-033391619IPR016024
DomainRap_GAP

RALGAPA1 SIPA1L2

3.18e-03101612PF02145
DomainRap_GAP_dom

RALGAPA1 SIPA1L2

3.86e-03111612IPR000331
DomainRAPGAP

RALGAPA1 SIPA1L2

3.86e-03111612PS50085
DomainIntegrin_alpha

ITGAM ITGAX

3.86e-03111612PF00357
DomainPKD_channel

PKD2L1 PKDREJ

3.86e-03111612PF08016
DomainPKD1_2_channel

PKD2L1 PKDREJ

3.86e-03111612IPR013122
DomainGRIP_dom

RGPD2 TRIP11

4.61e-03121612IPR000237
DomainGRIP

RGPD2 TRIP11

4.61e-03121612PS50913
DomainVWFA

COL12A1 ITGAM ITGAX COCH

5.52e-03821614PS50234
DomainVWA

COL12A1 ITGAM ITGAX COCH

6.01e-03841614SM00327
DomainNeurexin-like

CADM2 CNTNAP2

6.28e-03141612IPR003585
Domain4.1m

CADM2 CNTNAP2

6.28e-03141612SM00294
DomainPSI

PLXNA3 SEMA4G PLXNA1

6.43e-03441613IPR016201
DomainEF-hand_like

PLCB2 PLCE1

7.20e-03151612PF09279
DomainPI-PLC-Y

PLCB2 PLCE1

7.20e-03151612PF00387
DomainPLCYc

PLCB2 PLCE1

7.20e-03151612SM00149
DomainPI3/4_kinase_CS

ATR PIK3CD

7.20e-03151612IPR018936
DomainPLipase_C_Pinositol-sp_Y

PLCB2 PLCE1

7.20e-03151612IPR001711
DomainPIPLC_Y_DOMAIN

PLCB2 PLCE1

7.20e-03151612PS50008
DomainPI-PLC_fam

PLCB2 PLCE1

7.20e-03151612IPR001192
DomainPLC_EF-hand-like

PLCB2 PLCE1

7.20e-03151612IPR015359
DomainEMP24_GP25L

TMED1 TMED5

7.20e-03151612PF01105
DomainPSI

PLXNA3 SEMA4G PLXNA1

7.28e-03461613SM00423
DomainiLBP

FABP9 PMP2

8.19e-03161612IPR031259
Domain-

ATR PIK3CD

8.19e-031616121.10.1070.11
DomainPI3Kc

ATR PIK3CD

8.19e-03161612SM00146
DomainFatty_acid-bd

FABP9 PMP2

8.19e-03161612IPR000463
DomainIntegrin_alpha_C_CS

ITGAM ITGAX

8.19e-03161612IPR018184
DomainFABP

FABP9 PMP2

8.19e-03161612PS00214
DomainAAA

DNAH3 ABCA13 ATAD3C DNAH9 DYNC1H1

8.24e-031441615SM00382
DomainAAA+_ATPase

DNAH3 ABCA13 ATAD3C DNAH9 DYNC1H1

8.24e-031441615IPR003593
PathwayREACTOME_SIGNALING_BY_FLT3_FUSION_PROTEINS

TRIP11 GAB2 STAT5A STAT5B

2.79e-05191354M41732
PathwayKEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY

PPP2R2D PPP2R3B PPP2R2B PPP2R2C

2.79e-05191354M47525
PathwayREACTOME_STAT5_ACTIVATION

GAB2 STAT5A STAT5B

2.92e-0571353M27953
PathwayKEGG_MEDICUS_REFERENCE_CD80_CD86_CTLA4_PP2A_SIGNALING_PATHWAY

PPP2R2D PPP2R3B PPP2R2B PPP2R2C

5.15e-05221354M47919
PathwayREACTOME_STAT5_ACTIVATION_DOWNSTREAM_OF_FLT3_ITD_MUTANTS

GAB2 STAT5A STAT5B

9.81e-05101353M41731
PathwayREACTOME_FLT3_SIGNALING_IN_DISEASE

TRIP11 GAB2 STAT5A STAT5B

1.38e-04281354M41724
Pubmed

Stat5 expression is critical for mast cell development and survival.

STAT5A STAT5B KITLG IL1RL1

7.82e-096168412714518
Pubmed

Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement.

GAB2 STAT5A STAT5B

4.41e-074168319258595
Pubmed

Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5.

GAB2 STAT5A STAT5B

4.41e-074168320161778
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

FLNB CHD8 TTC3 YEATS2 TMEM129 SACS CLTC DENND6B CAMSAP1 TOP2A DYNC1H1

7.25e-073321681137433992
Pubmed

IL-33 expands suppressive CD11b+ Gr-1(int) and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival.

ITGAM KITLG IL1RL1

1.10e-065168321949025
Pubmed

Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development.

PPP2R2D CASP3 PPP2R2B PPP2R2C

1.92e-0619168432582689
Pubmed

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.

STAT5A STAT5B PLCB2

2.19e-066168319647226
Pubmed

HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.

PPP2R2D PPP2R2B PPP2R2C

3.82e-067168325816751
Pubmed

The secreted metalloprotease ADAMTS20 is required for melanoblast survival.

CASP3 KITLG VCAN

6.09e-068168318454205
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

RALGAPA1 FLNB RTN4 SPTB NAP1L1 ZC3HC1 GRIN2A TRIP11 PRPF40A CADM2 ALG2 PPP2R2C KIDINS220 ATAD3C SACS VCAN CLTC USP7 SSH2 SIPA1L2 DYNC1H1

6.14e-0614311682137142655
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

RNF121 MUC16 ZC3HC1 TRIP11 SRPRB GAB2 KIDINS220 RBM19 CLTC PKLR CAMSAP1 SMCR8 DYNC1H1 HELLS XPO7

6.16e-067771681535844135
Pubmed

Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis.

CASP3 ITGAM KITLG

9.10e-069168330166337
Pubmed

Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development.

PPP2R2D PPP2R2B PPP2R2C

9.10e-069168319762425
Pubmed

A brain-specific homeobox gene, Bsx, is essential for proper postnatal growth and nursing.

CASP3 STAT5A STAT5B

1.30e-0510168317485440
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

RTN4 NAP1L1 CASP3 TRIP11 PRPF40A YEATS2 LIG3 R3HCC1L TPX2 USP7 EIF3I CAMSAP1 SIPA1L2 SMCR8 TOP2A HELLS

1.32e-059341681633916271
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPC3 TRPM2 PKD2L1 PKDREJ

1.93e-0533168419834762
Pubmed

Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.

STAT5A STAT5B

2.32e-052168223151802
Pubmed

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

STAT5A STAT5B

2.32e-052168226999798
Pubmed

Association of ITGAX and ITGAM gene polymorphisms with susceptibility to IgA nephropathy.

ITGAM ITGAX

2.32e-052168231227791
Pubmed

A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.

STAT5A STAT5B

2.32e-052168231443474
Pubmed

Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.

STAT5A STAT5B

2.32e-052168212377952
Pubmed

A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.

STAT5A STAT5B

2.32e-052168221127177
Pubmed

The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.

STAT5A STAT5B

2.32e-052168216289657
Pubmed

Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.

STAT5A STAT5B

2.32e-052168225552366
Pubmed

Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.

STAT5A STAT5B

2.32e-052168225470773
Pubmed

Constitutively active Stat5A and Stat5B promote adipogenesis.

STAT5A STAT5B

2.32e-052168221431790
Pubmed

Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients.

GRIN2A AKAP11

2.32e-052168236914641
Pubmed

Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.

STAT5A STAT5B

2.32e-052168228500076
Pubmed

STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species.

STAT5A STAT5B

2.32e-052168221826656
Pubmed

Leukocyte integrins.

ITGAM ITGAX

2.32e-05216828573344
Pubmed

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

STAT5A STAT5B

2.32e-05216827720707
Pubmed

BCR activated CLL B cells use both CR3 (CD11b/CD18) and CR4 (CD11c/CD18) for adhesion while CR4 has a dominant role in migration towards SDF-1.

ITGAM ITGAX

2.32e-052168234283878
Pubmed

STAT5A and STAT5B have opposite correlations with drug response gene expression.

STAT5A STAT5B

2.32e-052168227264955
Pubmed

Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function.

STAT5A STAT5B

2.32e-052168222159083
Pubmed

The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP).

CASP3 USP7

2.32e-052168212413694
Pubmed

STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.

STAT5A STAT5B

2.32e-052168220008792
Pubmed

STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.

STAT5A STAT5B

2.32e-052168233199496
Pubmed

Current understanding of mammalian TRP homologues.

TRPC3 TRPM2

2.32e-052168212098215
Pubmed

The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.

STAT5A STAT5B

2.32e-052168216502315
Pubmed

Stat5: an essential regulator of mast cell biology.

STAT5A STAT5B

2.32e-052168212217382
Pubmed

Brain STAT5 Modulates Long-Term Metabolic and Epigenetic Changes Induced by Pregnancy and Lactation in Female Mice.

STAT5A STAT5B

2.32e-052168231599926
Pubmed

DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.

STAT5A STAT5B

2.32e-052168210594041
Pubmed

Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells.

STAT5A STAT5B

2.32e-052168221036145
Pubmed

Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice.

STAT5A STAT5B

2.32e-052168210486277
Pubmed

Identification of a novel nuclear localization signal in Tbx1 that is deleted in DiGeorge syndrome patients harboring the 1223delC mutation.

TBX10 TBX1

2.32e-052168215703190
Pubmed

Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.

STAT5A STAT5B

2.32e-052168216840779
Pubmed

The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.

STAT5A STAT5B

2.32e-052168215128421
Pubmed

STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.

STAT5A STAT5B

2.32e-052168230377054
Pubmed

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.

STAT5A STAT5B

2.32e-052168223565285
Pubmed

Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.

STAT5A STAT5B

2.32e-052168232790723
Pubmed

In vivo identification of novel STAT5 target genes.

STAT5A STAT5B

2.32e-052168218492722
Pubmed

Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption.

STAT5A STAT5B

2.32e-052168210066807
Pubmed

Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains.

STAT5A STAT5B

2.32e-052168210835485
Pubmed

Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis.

STAT5A STAT5B

2.32e-052168235464049
Pubmed

Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity.

STAT5A STAT5B

2.32e-052168218286195
Pubmed

Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells.

STAT5A STAT5B

2.32e-052168223773921
Pubmed

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.

STAT5A STAT5B

2.32e-05216828631883
Pubmed

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.

STAT5A STAT5B

2.32e-052168211030348
Pubmed

Association between STAT5 polymorphisms and glioblastoma risk in Han Chinese population.

STAT5A STAT5B

2.32e-052168224878107
Pubmed

Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5.

STAT5A STAT5B

2.32e-052168212847485
Pubmed

Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma.

STAT5A STAT5B

2.32e-052168212835478
Pubmed

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

STAT5A STAT5B

2.32e-05216827568026
Pubmed

Identification of STAT5A and STAT5B target genes in human T cells.

STAT5A STAT5B

2.32e-052168224497979
Pubmed

Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.

STAT5A STAT5B

2.32e-052168217536022
Pubmed

STAT5 transcriptional activity is impaired by LIF in a mammary epithelial cell line.

STAT5A STAT5B

2.32e-052168217382296
Pubmed

STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation.

STAT5A STAT5B

2.32e-052168217911616
Pubmed

STAT5 signaling in sexually dimorphic gene expression and growth patterns.

STAT5A STAT5B

2.32e-052168210486314
Pubmed

The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging.

STAT5A STAT5B

2.32e-052168217599554
Pubmed

MiR-21 is under control of STAT5 but is dispensable for mammary development and lactation.

STAT5A STAT5B

2.32e-052168224497923
Pubmed

Constitutive activation of STAT5A and STAT5B regulates IgM secretion in Waldenstrom's macroglobulinemia.

STAT5A STAT5B

2.32e-052168224335105
Pubmed

Brain STAT5 signaling modulates learning and memory formation.

STAT5A STAT5B

2.32e-052168229460051
Pubmed

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.

STAT5A STAT5B

2.32e-052168228606561
Pubmed

Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells.

CDH23 USH2A

2.32e-052168217360538
Pubmed

Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells.

STAT5A STAT5B

2.32e-052168212393407
Pubmed

The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter.

STAT5A STAT5B

2.32e-052168212039059
Pubmed

Neuronal migration defects in the Loa dynein mutant mouse.

DNAH1 DYNC1H1

2.32e-052168221612657
Pubmed

Differential changes in responses of hypothalamic and brainstem neuronal populations to prolactin during lactation in the mouse.

STAT5A STAT5B

2.32e-052168221178171
Pubmed

Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

STAT5A STAT5B

2.32e-052168220233708
Pubmed

Involvement of the STAT5 signaling pathway in the regulation of mouse preimplantation development.

STAT5A STAT5B

2.32e-052168216775227
Pubmed

STAT5 isoforms: controversies and clarifications.

STAT5A STAT5B

2.32e-052168217447893
Pubmed

Deletion of the complement phagocytic receptors CR3 and CR4 does not alter susceptibility to experimental cerebral malaria.

ITGAM ITGAX

2.32e-052168222882618
Pubmed

Integrin CD11c contributes to monocyte adhesion with CD11b in a differential manner and requires Src family kinase activity.

ITGAM ITGAX

2.32e-052168218541300
Pubmed

Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence.

STAT5A STAT5B

2.32e-052168216115927
Pubmed

Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration.

STAT5A STAT5B

2.32e-052168223275557
Pubmed

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation.

STAT5A STAT5B

2.32e-052168211867689
Pubmed

Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes.

STAT5A STAT5B

2.32e-052168215980098
Pubmed

Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation.

STAT5A STAT5B

2.32e-052168215340066
Pubmed

STAT5A/B gene locus undergoes amplification during human prostate cancer progression.

STAT5A STAT5B

2.32e-052168223660011
Pubmed

Role of Stat5 in type I interferon-signaling and transcriptional regulation.

STAT5A STAT5B

2.32e-052168212901872
Pubmed

CD11c- and CD11b-expressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain.

ITGAM ITGAX

2.32e-052168216051744
Pubmed

O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.

STAT5A STAT5B

2.32e-052168228074064
Pubmed

STAT5b: A master regulator of key biological pathways.

STAT5A STAT5B

2.32e-052168236755813
Pubmed

Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets.

UBE3A USP7

2.32e-052168220930542
Pubmed

Identification of isoform-specific dynamics in phosphorylation-dependent STAT5 dimerization by quantitative mass spectrometry and mathematical modeling.

STAT5A STAT5B

2.32e-052168225333863
Pubmed

A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance.

STAT5A STAT5B

2.32e-052168212421978
Pubmed

A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct DNA binding specificities.

STAT5A STAT5B

2.32e-05216829852045
Pubmed

Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior.

STAT5A STAT5B

2.32e-052168219966185
Pubmed

Signal transducer and activator of transcription 5a/b: biomarker and therapeutic target in prostate and breast cancer.

STAT5A STAT5B

2.32e-052168221704724
Pubmed

Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.

STAT5A STAT5B

2.32e-052168238618957
Pubmed

Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone.

STAT5A STAT5B

2.32e-05216828732682
InteractionFOXD3 interactions

PPP2R2D LIG3 PPP2R2B USP7 TOP2A

2.92e-06281655int:FOXD3
GeneFamilyWD repeat domain containing|Protein phosphatase 2 regulatory subunits

PPP2R2D PPP2R3B PPP2R2B PPP2R2C

2.15e-06151174696
GeneFamilySerpin peptidase inhibitors

SERPINI2 SERPINE1 SERPINC1 SERPINA7

9.33e-05371174739
GeneFamilyDyneins, axonemal

DNAH3 DNAH1 DNAH9

1.68e-04171173536
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

DENND1A DENND6B SMCR8

5.47e-04251173504
GeneFamilyTransient receptor potential cation channels

TRPC3 TRPM2 PKD2L1

7.69e-04281173249
GeneFamilyPlexins

PLXNA3 PLXNA1

1.45e-0391172683
GeneFamilyTransmembrane p24 trafficking proteins

TMED1 TMED5

1.81e-031011721064
CoexpressionMITSIADES_RESPONSE_TO_APLIDIN_DN

TTC3 RSRC1 FANCI CLTC TPX2 USP7 AKAP11 CAMSAP1 TOP2A HELLS

5.23e-0625016810M11318
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 ABCA13 CADM2 RYR3 DNAH1 LOXHD1 DGKK MYOCD UNC13C USH2A DNAH9 PLCE1

6.18e-12184168122cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 ABCA13 CADM2 RYR3 DNAH1 LOXHD1 DGKK MYOCD UNC13C USH2A DNAH9 PLCE1

6.18e-1218416812ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 ABCA13 CADM2 RYR3 DNAH1 LOXHD1 DGKK MYOCD UNC13C USH2A DNAH9 PLCE1

6.18e-12184168122b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08-Neuronal|GW08 / Sample Type, Dataset, Time_group, and Cell type.

TMEM14A TTC3 PPP2R2B KIDINS220 CNTNAP2 DYNC1H1

5.93e-078016865c39136f5f855efbf61e1f5348ea97ea2130b241
ToppCellPSB-critical-LOC-Epithelial-FOXN4+|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

COCH FANCI TPX2 CNTNAP2 CEP295 TOP2A PLCE1 HELLS

7.34e-071931688b7d9c5bed524423e92f01496a9f8fad11b33a3f7
ToppCellmoderate-Epithelial-FOXN4+|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PNMA1 ABCA13 CASP3 KITLG FANCI CEP295 PLCE1 HELLS

7.63e-0719416885dffa578149104dda33774361e9e77b227b5f1ce
ToppCellChildren_(3_yrs)-Immune-monocyte-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRPM2 ITGAM DENND1A PIK3CD VCAN MYO1F PLCB2 SSH2

7.93e-07195168881a28289eda1a8a1a31b7357106f64ac5000e172
ToppCellAdult-Immune-monocyte|Adult / Lineage, Cell type, age group and donor

CDH23 ITGAM ITGAX DENND1A PIK3CD VCAN MYO1F PLCB2

8.24e-0719616883ef193c5180de3137daf886492e74fc574bc9767
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|lung / Disease (COVID-19 only), tissue and cell type

ITGAM ITGAX DENND1A PIK3CD VCAN MYO1F PLCB2 SSH2

8.56e-071971688a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCellParenchymal-NucSeq-Immune_Myeloid-Monocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CDH23 ITGAM ITGAX DENND1A PIK3CD VCAN MYO1F PLCB2

9.59e-072001688fd72fe6565e2f4885481991492d58c323ab1ad40
ToppCellcritical-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CASP3 KITLG FANCI TPX2 CEP295 TOP2A PLCE1 HELLS

9.59e-072001688f39db4250ce220a3eb58edee3f7fc3671701d46f
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells-Neuroepithelial_cell|GW08 / Sample Type, Dataset, Time_group, and Cell type.

POLH R3HCC1L TPX2 PINX1 ALDH4A1 TOP2A PLCE1 HELLS

9.59e-0720016884e077aa7faddcebdfc54667f8b3990704441005b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells|GW08 / Sample Type, Dataset, Time_group, and Cell type.

POLH R3HCC1L TPX2 PINX1 ALDH4A1 TOP2A PLCE1 HELLS

9.59e-072001688d17ba4239e1fd702a3d757687110f0f2c6f91ef7
ToppCellParenchymal-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD14|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRPM2 ITGAM ITGAX DENND1A PIK3CD VCAN MYO1F PLCB2

9.59e-072001688b4277b6faa69f20974696c7c422311f5c89e3663
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Neuronal-Cortical_neuron|GW12 / Sample Type, Dataset, Time_group, and Cell type.

TMEM14A CASP3 TTC3 PPP2R2B KIDINS220 CNTNAP2

1.54e-06941686a752c80fb2e83cffa22a00d7e98c24406ee41908
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 CADM2 RYR3 CNTNAP2 MYOCD USH2A DNAH9

2.58e-061601687c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 CADM2 RYR3 CNTNAP2 MYOCD USH2A DNAH9

2.58e-06160168725c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK3 ABCA13 USP29 PKD2L1 PPP2R2B USH2A DNAH9

2.80e-061621687bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 RYR3 DNAH1 CNTNAP2 UNC13C USH2A DNAH9

3.70e-06169168712bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM2 ITGAM PIK3CD FANCI TPX2 MYO1F TOP2A

4.16e-061721687ef33b5e0515c6d29fb6d9a673011c1b68ef264f3
ToppCelldroplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RALGDS ITGAX TBC1D9 PLIN2 SERPINE1 BCAR3 SH3BGRL2

6.47e-0618416878fa30789c9d583188667cf375d2218e392dd40bc
ToppCelldroplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RALGDS ITGAX TBC1D9 PLIN2 SERPINE1 BCAR3 SH3BGRL2

6.71e-0618516874bee178ede12f56ba5f5bec44a03dc2a62c50137
ToppCelldroplet-Lung-nan-18m-Myeloid-alveolar_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RALGDS ITGAX TBC1D9 PLIN2 SERPINE1 BCAR3 SH3BGRL2

7.20e-061871687f0c6e53035b00772377c4d5f761b4d11026b911a
ToppCelldroplet-Lung-nan-18m-Myeloid-Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RALGDS ITGAX TBC1D9 PLIN2 SERPINE1 BCAR3 SH3BGRL2

7.20e-061871687f20e7a1751694390f535ffb27b97e887220f8695
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPC3 TRPM2 TTC3 ITGAX SEMA4G TBC1D9 MEDAG

7.45e-0618816871efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCellControl-Myeloid-Monocytes|Control / group, cell type (main and fine annotations)

CDH23 ITGAX DENND1A GAB2 VCAN MYO1F SSH2

7.71e-0618916873335d16bd0ffa0c1ddd06d7da645299148130c3f
ToppCellNS-moderate-d_16-33-Epithelial-FOXN4+|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PNMA1 KITLG FANCI TPX2 CEP295 PLCE1 HELLS

7.98e-061901687250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCellAdult-Immune-monocyte-D175|Adult / Lineage, Cell type, age group and donor

TRPM2 ITGAM ITGAX DENND1A PIK3CD MYO1F PLCB2

8.26e-061911687cbebb4d9550fdcd606cb3685ac9546c6b73fd422
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Non-classical_Monocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ITGAM ITGAX GAB2 VCAN MYO1F PLCB2 SSH2

8.26e-06191168747a2afc4102199b4bc76bd01b2967c8016186462
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

RALGAPA1 ATR TRIP11 CLTC CRYBG3 SMCR8 DYNC1H1

8.84e-061931687abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellmoderate-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PNMA1 FANCI TPX2 CEP295 TOP2A PLCE1 HELLS

9.14e-061941687dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM2 CDH23 ITGAM ITGAX TBC1D22A VCAN MYO1F

9.46e-06195168762dc745e1aa3e2e58afa16c7bb2cf9b03d4e8105
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CDH23 ITGAM ITGAX PIK3CD VCAN MYO1F PLCB2

9.46e-06195168710ce1b6961f10372d1f65388cbf3626a5fcd6840
ToppCellAdult-Immune-monocyte-D122|Adult / Lineage, Cell type, age group and donor

TRPM2 ITGAM ITGAX PIK3CD VCAN MYO1F PLCB2

9.78e-06196168716b0acb6157534938ca83d4e909471e33a7d3c52
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

ITGAM ITGAX DENND1A PIK3CD VCAN MYO1F PLCB2

9.78e-061961687cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM2 ITGAM ITGAX TBC1D22A PIK3CD MYO1F PLCB2

1.01e-051971687826cc6baafab13e7ef5cfcf28cd79d0fbf3af38d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM2 ITGAM ITGAX GAB2 VCAN MYO1F PLCB2

1.01e-0519716871eb9ff8467118b943b5d443cb996168e1e1206b5
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

ITGAM ITGAX PIK3CD VCAN MYO1F PLCB2 SSH2

1.04e-051981687ea34096bee852a7e996f097fa279381afa8f86ff
ToppCellImmune-monocyte|World / Lineage, Cell type, age group and donor

ITGAM ITGAX DENND1A PIK3CD VCAN MYO1F PLCB2

1.04e-051981687d3622da252fd580f1dc5c7478a8e23df5ec083cf
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IL31RA RPS6KC1 PPP2R2B MLH3 TPX2 USH2A

1.05e-0513116861823cab28fab40486247ca92104267b1e370bdc1
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL12A1 NAP1L1 VCAN PDE5A FAIM2 TOP2A HELLS

1.08e-05199168701ab0363558f215f9979e20fd5170d8fee149cea
ToppCellParenchymal-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CDH23 ITGAM ITGAX DENND1A PIK3CD MYO1F PLCB2

1.08e-051991687ac866ae110967c5867ff4601939b79861d43df54
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FLNB ITGAM ITGAX STAT5A PLIN2 VCAN MYO1F

1.11e-052001687851c57187db8bc91a393655bca5f13e787a723d4
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

ABCA13 GRIN2A CADM2 CNTNAP2 USH2A DNAH9

1.95e-051461686c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCellCOVID-19-Epithelial_cells-Airway_mucous|COVID-19 / group, cell type (main and fine annotations)

DNAH3 ABCA13 MUC16 SERPINI2 CNTNAP2 DNAH9

2.36e-0515116868216462e723fec2797387929dde095370947e10a
ToppCellPND14-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGAX AKAP11 IL1RL1 TOP2A HELLS XPO7

2.83e-0515616868349604bd801e20d33770f7d8243598c3756302b
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM2 ITGAX GAB2 MYO1F PLXNA1 GABBR1

2.94e-051571686ec433d2fe827abdb647be4176c231b7052482b6f
ToppCellNS-moderate-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 SERPINI2 FANCI CEP295 PLCE1 HELLS

2.94e-051571686410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 PKD2L1 GRIN2A PKDREJ DGKK UNC13C

3.04e-051581686f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 PKD2L1 GRIN2A PKDREJ DGKK UNC13C

3.04e-0515816868c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

DNAH3 CADM2 MYO1F CNTNAP2 USH2A DNAH9

3.63e-05163168619c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM2 ITGAX ST6GALNAC2 GAB2 PLXNA1 GABBR1

3.63e-0516316868dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM2 ITGAX ST6GALNAC2 GAB2 PLXNA1 GABBR1

3.63e-051631686fd243ca223079033be480a24817a399f281fa4d4
ToppCellCiliated_cells-B-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

DNAH3 ABCA13 MUC16 RYR3 CFAP74 DNAH9

3.75e-0516416860e9961acbb1d6c0089e6805ba6756736fa4d8bed
ToppCellfacs-Marrow-KLS-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL31RA SPTB ST6GALNAC2 KITLG SH3BGRL2 XPO7

3.88e-0516516864f95c2fe5ab4416c736fe0d1936695a2b26777eb
ToppCellfacs-Marrow-KLS-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL31RA SPTB ST6GALNAC2 KITLG SH3BGRL2 XPO7

3.88e-0516516863e913b49a868fdd5589200ae3e9be77c0938ba14
ToppCellfacs-Marrow-B-cells-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNMA1 COPZ2 SPTB CDH23 EVC EDEM1

3.88e-051651686361a605d8f833d9ec54b120480dce397da35f9c3
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EVC FANCI DGKK PDE5A MYOCD UNC13C

4.15e-05167168691b14df450bfb6a2b406c88f8c75cd51eeb9e82b
ToppCellfacs-Marrow-KLS-3m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COPZ2 CDH23 EVC SRPRB EDEM1 SH3BGRL2

4.44e-051691686b798b91567d2f49082e2d8a337169f241c8d2080
ToppCellPND14-Immune-Immune_Myeloid-DC-cDC2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGAM ITGAX TBC1D9 TPX2 IL1RL1 TOP2A

4.58e-0517016869e94fa0d05abed3438b28296a293767096d517d6
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Myeloid|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGAM PIK3CD TPX2 MYO1F PLCB2 TOP2A

4.58e-051701686d582087a983fe20d811d92f0de0458f3cfd71d2b
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Myeloid-macrophage|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGAM PIK3CD TPX2 MYO1F PLCB2 TOP2A

4.58e-051701686dfbe7ba11b867a4e10fa915f282a2e5cb2f5fb8c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL12A1 FANCI VCAN TPX2 TOP2A HELLS

4.74e-051711686b0373ed8283ee1792b6a490bff93906546978593
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Myeloid-new-cluster|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGAM PIK3CD TPX2 MYO1F PLCB2 TOP2A

4.74e-051711686d0d92eb5152410c3b4dd4a3f1dc3cca0e18a85fd
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-CX3CR1+_CD8_Tmem|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRPC3 ITGAM PPP2R2B PIK3CD DGKK MYO1F

4.74e-051711686187b396059f8802265f54bad2b4882cebb809419
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL12A1 FANCI VCAN TPX2 TOP2A HELLS

4.74e-051711686b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM2 ITGAM ITGAX PIK3CD MYO1F PLCB2

4.89e-051721686f6b4754a7e4b3e38030316a0ae00d932bfa87e41
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____podocyte-3|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPC3 DNAH1 GRHL1 PPP2R2C MEDAG FAIM2

5.22e-05174168676310c0af1d7df6a4de3816838b2ac2892f68746
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POLH COCH SPAAR TPX2 CRYBG3 TOP2A

5.22e-0517416866c36d607c48267a75ab4da6fb2fe3f931d1b3b52
ToppCellfacs-Marrow-B-cells-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 CADM2 CNTNAP2 BCAR3 USH2A DNAH9

5.39e-051751686887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM2 ITGAM ITGAX PIK3CD MYO1F PLCB2

5.56e-051761686926ed37e636fe4dd3a18731cea15761f0c2c285a
ToppCellfacs-Lung-EPCAM-3m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGAX TBC1D9 MYO1F PKLR PLCB2 IL1RL1

5.74e-051771686e73e2b6a72630bb56ac2af1cdeedc8f0f828f390
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 ABCA13 DNAH1 DENND6B CCDC191 DNAH9

5.92e-0517816863b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 NAP1L1 COCH TOP2A PLCE1 HELLS

6.11e-051791686d15182c668d7c37be8214cad9f1fe35d1409c9a1
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 NAP1L1 COCH TOP2A PLCE1 HELLS

6.11e-051791686e22a275a7c0ed19113c833a75d6c49fcc19aa13a
ToppCellCOVID-19-kidney-vSMC/Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

TRPC3 GRIN2A LGI2 MEDAG MYOCD PLCE1

6.11e-051791686111b1084f73306bdeffaaf240e7dbb4f5bf33de1
ToppCellLPS_only-Myeloid-Neutrophils|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRPM2 ITGAM ITGAX GAB2 VCAN MYO1F

6.11e-051791686d0a03e498afcfeb657037889685ecd77bed07e6c
ToppCellNS-critical-d_0-4-Myeloid-Mast_cell|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ZC3HC1 ZNF10 LIG3 PER3 ZNF41 IL1RL1

6.11e-0517916866153e7a0eeae83e7d88f1a20093bf2113e8d66b1
ToppCellLPS_only-Myeloid-Neutrophils-Neutrophils|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRPM2 ITGAM ITGAX GAB2 VCAN MYO1F

6.11e-051791686d034651a5a355a58f5e15db627869f4feebdfe35
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLNB POLH EVC DNAH1 SACS VCAN

6.30e-051801686c4068fe47408cfd899131a85fa4b7e5908926f94
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-LYVE1+_Macrophage|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ITGAM ITGAX VCAN MYO1F ALDH4A1 GABBR1

6.30e-05180168666c7b02d85e32ba3e7530d0c4aff17e7525ccdd8
ToppCelldroplet-Lung-LUNG-30m-Myeloid-alveolar_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGAX TBC1D9 PLIN2 SERPINE1 BCAR3 SH3BGRL2

6.49e-0518116868fcdab61fad2efd324d2b27c58f5a594f1dc15de
ToppCellLPS_only-Myeloid|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRPM2 ITGAM ITGAX GAB2 VCAN MYO1F

6.69e-051821686666ac86ee5f6fa9241ae8d80340743707e54b278
ToppCellfacs-Aorta-Heart-3m-Myeloid-macrophage|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASP3 ITGAX TBC1D9 PIK3CD PLCB2 TOP2A

6.69e-051821686df26388c0c46d1c4775103c8e802937b4d4e7470
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGAX TBC1D9 PLIN2 SERPINE1 BCAR3 SH3BGRL2

6.69e-051821686be48ce85991bceeff938ba080e6bf9cc62176b05
ToppCell5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

POLH COCH TPX2 CNTNAP2 PKLR TOP2A

6.90e-051831686d4aa21ba4f6f92e25ecff80b7399bca31527fd7e
ToppCelldroplet-Lung-nan-3m-Myeloid-Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGAX TBC1D9 PLIN2 SERPINE1 BCAR3 SH3BGRL2

6.90e-051831686ec3c05b9ce1e0fbb720e0dea41f1e28fd3fd878f
ToppCellfacs-Aorta-Heart-3m-Myeloid-leukocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASP3 ITGAX TBC1D9 PIK3CD PLCB2 TOP2A

6.90e-051831686062ec08d66c923f90fee771b1bf8d98bdc7e6c1b
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1-41|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RALGDS ZFP90 GAB2 VCAN MEDAG FAIM2

6.90e-05183168607ca2786e62eca9feecf5e54a11864a960f7641a
ToppCellnormal-na-Lymphocytic-lymphocyte-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

RNF121 TPX2 SPDYA TOP2A DOP1A HELLS

7.11e-0518416862c286712428662bc4589dc5ac4011bf7ed403cb5
ToppCelldroplet-Lung-nan-3m-Myeloid-alveolar_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGAX TBC1D9 PLIN2 SERPINE1 BCAR3 SH3BGRL2

7.11e-0518416863261d767d5e3d9e9fbac22ad73ca14e44beed89c
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l33-52|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PSD ABCA13 FANCI TPX2 TOP2A HELLS

7.33e-05185168647c69500877b851c0c9744f5e1ef2ee0bff99168
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

DNAH3 ABCA13 MUC16 SERPINI2 CFAP74 DNAH9

7.33e-05185168618a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell368C-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

PPP2R2B TPX2 ALDH4A1 TOP2A HELLS XPO7

7.55e-051861686799903b68bc6f6205d004b44c603424b0d5f7c32
ToppCelldroplet-Lung-nan-21m-Myeloid-Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGAX TBC1D9 PLIN2 SERPINI2 SERPINE1 BCAR3

7.55e-051861686f1aa0c58336d23bcbe52a59e7af954d20085bdb6
ToppCell356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|356C / Donor, Lineage, Cell class and subclass (all cells)

ADGRL4 LOXHD1 KITLG SPAAR SERPINE1 IL1RL1

7.55e-051861686f0b78c7ee20279970ea8961bf59acb5262f2dce5
ToppCellLPS-antiTNF-Myeloid|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRPM2 ITGAM ITGAX GAB2 VCAN MYO1F

7.55e-051861686839c6da5244f469461b2e5563e36162b2911cd01
ToppCelldroplet-Lung-nan-21m-Myeloid-alveolar_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGAX TBC1D9 PLIN2 SERPINI2 SERPINE1 BCAR3

7.55e-0518616868f77e552e613b6e124443c7f6ef5c1316a5ff8db
ToppCell356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|356C / Donor, Lineage, Cell class and subclass (all cells)

ADGRL4 LOXHD1 KITLG SPAAR SERPINE1 IL1RL1

7.55e-0518616862b3c814a7dee8286ea113c63dc3de5daf0257d37
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

POLH FANCI TPX2 UNC13C TOP2A HELLS

7.77e-051871686057569c9437219ecc396aa6e673b1178a2273837
Drug2,4,5,2',5'-pentachlorobiphenyl

PLXNA3 COL12A1 COPZ2 PSD ATR ABCA13 RPS6KA3 TMED5 ZNF184 CASP3 CDH23 GRIN2A FABP9 TTC3 ADGRL4 TBC1D20 RPS6KC1 PPP2R2B LOXHD1 COCH SACS FANCI TPX2 CNTNAP2 PDE5A CEP295 CRYBG3 FAIM2 TOP2A XPO7

1.50e-07144116530ctd:C009828
Drug2,4,4'-trichlorobiphenyl

PLXNA3 COL12A1 COPZ2 PSD ATR ABCA13 RPS6KA3 TMED5 ZNF184 CDH23 GRIN2A FABP9 TTC3 ADGRL4 TBC1D20 RPS6KC1 PPP2R2B LOXHD1 COCH SACS FANCI TPX2 CNTNAP2 PDE5A CEP295 CRYBG3 FAIM2 TOP2A XPO7

3.27e-07141116529ctd:C081766
DrugVanadates

FLNB ZFP90 IL31RA ZNF484 ERAP1 TMEM14A TRPC3 CASP3 ZNF510 HIBADH ALG2 STAT5A STAT5B PLIN2 MED24 LIG3 KITLG PER3 LGI2 MEDAG MYOCD IL1RL1 SIPA1L2 TOP2A PLCE1 HELLS

2.47e-06130216526ctd:D014638
DrugN-methylformamide

PPCS ITGAM ITGAX KITLG TBX1 PMP2

8.39e-06661656CID000031254
Drug2-propylpentanoic acid; Down 200; 1000uM; HL60; HT_HG-U133A

TMED1 ERAP1 TRPM2 ACAD10 STAT5A GSS LIG3 PIK3CD PLCE1

9.34e-0618716592669_DN
DrugDapsone [80-08-0]; Down 200; 16.2uM; PC3; HT_HG-U133A

DNAH3 POLH TRIP11 SEMA4G TBC1D9 RBM19 INTS15 IL1RL1 PLXNA1

1.31e-0519516591827_DN
DrugCalcium

RALGDS TRPC3 TRPM2 CASP3 ALG2 RYR3 PROKR1 S100A13 PIK3CD SERPINE1 PKLR AKAP11 GABBR1 NR1D2

1.52e-0549316514ctd:D002118
Drug(1)-Nipecotic acid [498-95-3]; Up 200; 31uM; HL60; HT_HG-U133A

PLXNA3 USP29 ST6GALNAC2 SEMA4G PPP2R2B CNTNAP2 ALDH4A1 PLXNA1 PLCE1

1.54e-0519916593121_UP
DrugAH6809; Down 200; 1uM; PC3; HT_HG-U133A

PLXNA3 DNAH3 ACAD10 TBC1D9 RSRC1 MLH3 PER3 TBC1D22A VCAN

1.54e-0519916597075_DN
DrugCaffeine

ATR RPS6KA3 TRPC3 TMED5 CASP3 ITGAM RYR3 PPP2R2B KIDINS220 COCH VCAN PDE5A IL1RL1 HELLS

2.46e-0551516514ctd:D002110
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

PPP2R2D PPP2R2B PPP2R2C

3.57e-05121643DOID:1441 (implicated_via_orthology)
DiseaseNonsyndromic Deafness

CDH23 LOXHD1 COCH KITLG MYO1F

9.09e-05811645C3711374
Diseasefamilial encephalopathy with neuroserpin inclusion bodies (implicated_via_orthology)

SERPINI2 SERPINE1

1.83e-0441642DOID:0050831 (implicated_via_orthology)
Diseasethrombosis (is_marker_for)

ITGAM SERPINE1

1.83e-0441642DOID:0060903 (is_marker_for)
Diseasehearing impairment

RPS6KA3 CDH23 LOXHD1 COCH USH2A

2.23e-04981645C1384666
Diseasetetradecadienedioate (C14:2-DC) measurement

PNMA1 PKD2L1

4.54e-0461642EFO_0800585
Diseasedisseminated intravascular coagulation (implicated_via_orthology)

SERPINE1 SERPINC1

4.54e-0461642DOID:11247 (implicated_via_orthology)
Diseaseacute myocardial infarction (biomarker_via_orthology)

CASP3 IL1RL1 TBX1

4.99e-04281643DOID:9408 (biomarker_via_orthology)
Diseasechronic obstructive pulmonary disease (biomarker_via_orthology)

CASP3 SERPINE1 FAIM2

4.99e-04281643DOID:3083 (biomarker_via_orthology)
DiseaseColorectal Carcinoma

RALGDS DNAH3 CPAMD8 ABCA13 RTN4 GRIN2A ZNF232 LIG3 MLH3 SACS TPX2 TBX1

5.86e-0470216412C0009402
Diseasealpha 1-antitrypsin deficiency (implicated_via_orthology)

SERPINI2 SERPINC1

6.33e-0471642DOID:13372 (implicated_via_orthology)
Diseasehair colour measurement

TRIP11 DENND1A GAB2 GSS KITLG TBC1D22A FOLH1B UNC13C BCAR3 SIPA1L2 PLXNA1

6.86e-0461516411EFO_0007822
Diseasewaist circumference

RALGAPA1 CWC22 CADM2 TBC1D9 RBM19 CNTNAP2 UNC13C IL1RL1 FAIM2

6.97e-044291649EFO_0004342
Diseasefemale breast cancer (is_implicated_in)

POLH FANCI

8.41e-0481642DOID:0050671 (is_implicated_in)
DiseaseX-17676 measurement

DNAH3 ALDH4A1

8.41e-0481642EFO_0800785
Diseaselevel of Sterol ester (27:1/16:1) in blood serum

PKD2L1 DENND1A

1.08e-0391642OBA_2045190
DiseaseBipolar Disorder

ABCA13 TRPC3 TRPM2 GRIN2A ITGAM PPP2R2C PER3 CNTNAP2 MPPE1

1.46e-034771649C0005586
DiseaseCombined immunodeficiency

STAT5A STAT5B PIK3CD

1.54e-03411643C0494261
DiseaseRetinal Detachment

CPAMD8 CASP3

1.63e-03111642C0035305
DiseaseSemantic-Pragmatic Disorder

GRIN2A CNTNAP2

1.63e-03111642C0454655
Diseasegastric adenocarcinoma (is_implicated_in)

ABCA13 PLCE1

1.63e-03111642DOID:3717 (is_implicated_in)
DiseaseMitochondrial Myopathies

SLC25A42 CAMKMT

1.63e-03111642C0162670
DiseaseEnzymopathy

GSS PKLR

1.63e-03111642C0520572
DiseaseAuditory Processing Disorder, Central

GRIN2A CNTNAP2

1.63e-03111642C0751257
DiseaseLanguage Delay

GRIN2A CNTNAP2

1.63e-03111642C0023012
DiseaseLanguage Development Disorders

GRIN2A CNTNAP2

1.63e-03111642C0023014
DiseaseSpeech Delay

GRIN2A CNTNAP2

1.63e-03111642C0241210
Diseaseneutrophil count

FLNB CPAMD8 COPZ2 PPP2R2D CDH23 ZC3HC1 ADGRL4 MED24 KIDINS220 KITLG LGI2 AKAP11 UNC13C PLCB2 SSH2 USP47 HELLS

1.84e-03138216417EFO_0004833
Diseaseglioblastoma (is_marker_for)

STAT5A ADGRL4 PIK3CD

1.89e-03441643DOID:3068 (is_marker_for)
Diseasemultiple sclerosis symptom measurement

USP29 CAMKMT UNC13C

2.15e-03461643EFO_0803536
DiseaseAcute Promyelocytic Leukemia

ITGAM ITGAX STAT5B

2.15e-03461643C0023487
Diseasetoxic shock syndrome (is_implicated_in)

SERPINE1 SERPINC1

2.30e-03131642DOID:14115 (is_implicated_in)
Diseaseattention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia

GRIN2A CWC22 ADGRL4 PPP2R2B

2.47e-031011644EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
DiseasePneumoconiosis

ATR CDH23

2.67e-03141642C0032273
Diseaseventricular septal defect (is_implicated_in)

EVC TBX1

2.67e-03141642DOID:1657 (is_implicated_in)
DiseaseBagassosis

ATR CDH23

2.67e-03141642C0004681
Diseasechromosome 22q11.2 deletion syndrome, distal (implicated_via_orthology)

TBX10 TBX1

2.67e-03141642DOID:0060413 (implicated_via_orthology)
Diseasethrombosis (is_implicated_in)

SERPINE1 SERPINC1

3.07e-03151642DOID:0060903 (is_implicated_in)
DiseaseAutistic Disorder

CHD8 GRIN2A UBE3A SERPINE1 CNTNAP2 GABBR1

3.49e-032611646C0004352
Disease4-acetamidobutanoate measurement

TBC1D22A DENND6B

3.50e-03161642EFO_0021003
Diseasenervousness

DENND1A CADM2

3.50e-03161642NCIT_C74532
Diseaseautism spectrum disorder (is_implicated_in)

CADM2 CNTNAP2

3.50e-03161642DOID:0060041 (is_implicated_in)
Diseasealcohol use disorder (implicated_via_orthology)

PSD RYR3 PIK3CD UNC13C SSH2

4.77e-031951645DOID:1574 (implicated_via_orthology)
Diseaseovulation

FANCI ABRAXAS1

4.93e-03191642GO_0030728
Diseasetestosterone measurement

DOCK3 TRPM2 ZC3HC1 CWC22 PKDREJ GSS PLIN2 PER3 DGKK CNTNAP2 USP7 PINX1 MYOCD USH2A NR1D2

5.12e-03127516415EFO_0004908
Diseasetransient cerebral ischemia (implicated_via_orthology)

CASP3 ITGAM SERPINE1

5.48e-03641643DOID:224 (implicated_via_orthology)
Diseasebody fat distribution

DOCK3 VCAN PKLR NR1D2 PLCE1

5.53e-032021645EFO_0004341

Protein segments in the cluster

PeptideGeneStartEntry
FSRAVQTHSSKFFEE

ABRAXAS1

191

Q6UWZ7
FDTNSTDIALKVFFF

ADGRL4

246

Q9HBW9
FFSEIISSISDVKFS

PPP2R2B

276

Q00005
FFSEIISSVSDVKFS

PPP2R2C

276

Q9Y2T4
TFAKASFVASENRTD

CHD8

1351

Q9HCK8
ESQKIAFARATEVTF

VCAN

1556

P13611
TSAIFEFKEVLSNSE

CRYBG3

726

Q68DQ2
TVSSFRPNEFESKFL

BCAR3

511

O75815
VFNKTSRTESEIAFF

COPZ2

81

Q9P299
QLKTFPFNESTSREF

ABCA13

1266

Q86UQ4
SFFSLLTSERVAKQF

ACAD10

121

Q6JQN1
FFSEIISSISDVKFS

PPP2R2D

286

Q66LE6
TFFSAVIDAKSFARI

ALDH4A1

386

P30038
AFIELSQVDVTFTTK

AKAP11

701

Q9UKA4
NKSSSFVRSFDRSLF

DOP1A

946

Q5JWR5
DTISEKTSDQIHFFF

SERPINC1

141

P01008
IHDSEFKEFTTRTQA

DENND6B

311

Q8NEG7
RKVATEFESFSFDAT

CASP3

241

P42574
VASVKRFSTFSASKE

CAMSAP1

166

Q5T5Y3
EAIFSFIVKASSNRS

CDH23

2796

Q9H251
IADETSINTRSFSKF

R3HCC1L

401

Q7Z5L2
FIDTSRITVEFCKSF

RBM19

66

Q9Y4C8
VDAVISKIESTFARF

PPP2R3B

141

Q9Y5P8
SKFIAENSRDVFIDS

C9orf64

11

Q5T6V5
KFQTHFTFEEFRRSS

ITGAX

196

P20702
RTVTKTVSNDSFFNF

NAP1L1

286

P55209
TKDSVRQIIFSSLFS

INTS15

86

Q96N11
SSFSKNRFEDILSLF

FANCI

761

Q9NVI1
VFDKAFTAATTEVSR

MUC16

6386

Q8WXI7
TISVKNFSSTFFLED

DGKK

791

Q5KSL6
RLSETVRQNTKFFFD

HELLS

186

Q9NRZ9
FLATRLFRVFKTEDT

KIDINS220

631

Q9ULH0
CLSVTVFSFQTKFDF

FAIM2

206

Q9BWQ8
VFAFATREAFTKVTD

GLTPD2

121

A6NH11
TSINFKTLSFSVFEI

IL31RA

506

Q8NI17
ASRSFNTSESKVEFK

RPS6KC1

641

Q96S38
KEAGIEITFRQSFFS

GABBR1

331

Q9UBS5
FSEREASAVLFTITK

RPS6KA3

511

P51812
VFERASKDTFQTDTF

LOXHD1

856

Q8IVV2
FKVFEVTKTTESFAS

LOXHD1

1926

Q8IVV2
TSSSRIFVKIFFQEL

CWC22

576

Q9HCG8
VERFEKVFSSERLFS

MPPE1

171

Q53F39
QFSTRTRLEEVKGFF

ERAP1

881

Q9NZ08
KDVFREATTDFTVDS

FLNB

1241

O75369
RAFTQTDVATFSELT

HTD2

46

P86397
TSKNTDTFVAVFSFL

PER3

126

P56645
QKFVDDLFETIFSTA

PLXNA1

1691

Q9UIW2
QKFVDDLFETVFSTA

PLXNA3

1666

P51805
FSLFDATLQKRVTSD

MLH3

371

Q9UHC1
AQTLKITDFSFSDFE

PDE5A

551

O76074
TTTSAFTIQEYFAKR

PINX1

171

Q96BK5
FDSLFSAVKNFTEIA

FOLH1B

321

Q9HBA9
FTEIASKFSERLQDF

FOLH1B

331

Q9HBA9
DIVFASFVRKASDVA

PKLR

281

P30613
SETIRVFFEQSKSFP

LIG3

351

P49916
HTNVKEFFFLELTRS

OR4D6

6

Q8NGJ1
KFSVTSRGSIDDVFN

MEDAG

256

Q5VYS4
QVSFSKSTDAFAFEE

MYOCD

141

Q8IZQ8
FSVLFAISEVRSKES

INSL5

11

Q9Y5Q6
ECKIQFFSFAISVTT

OR5H1

96

A6NKK0
FEDFVAIISSTKRST

PRPF40A

696

O75400
ESRQSFVFIVTKDSE

PPCS

261

Q9HAB8
FVSFLEESISFVRSS

DNAH1

2041

Q9P2D7
FARKFVISIDTISFD

DNAH1

4131

Q9P2D7
FSTTETQGKDFTFVT

ATR

1371

Q13535
ATRSFTVKDEQGFSL

IL1RL1

196

Q01638
STFSETFKEGVQEVF

GRHL1

211

Q9NZI5
SLIFQRSTKESFFIS

DOCK3

581

Q8IZD9
FFNKDTRGEVQTVTF

COL12A1

2621

Q99715
VNVTFSFVKYRDTDT

DNAH3

1016

Q8TD57
VDKGTFLSFSDRVSQ

CPAMD8

1356

Q8IZJ3
TTTSTRIGKFEARFF

EIF3I

256

Q13347
EKASEFAVSNAFFTR

CCDC191

46

Q8NCU4
HFELKTFQTVRIFSE

CC2D1B

681

Q5T0F9
DANRKTFTVSSTLDF

CADM2

176

Q8N3J6
FRAFVTDRDKVTATV

ATAD3C

61

Q5T2N8
NTVSFDKDSTVQVFE

EDEM1

211

Q92611
RDSFRIFQKLSEIFS

RALGDS

506

Q12967
FTFVLTDIDSKQRFG

DENND1A

71

Q8TEH3
NTFLERLFTTRSFDS

DYNC1H1

4266

Q14204
RLFTTRSFDSEFKLA

DYNC1H1

4271

Q14204
LAQEEIRFSFSTTKA

CNTNAP2

1046

Q9UHC6
STVDTFQKFVDALFL

EVC

526

P57679
VVSDTLSFFKQEFQD

DNAH9

396

Q9NYC9
SSTIKQDDFTARLFD

GSS

91

P48637
QDARKISETFGATTF

CEP295

746

Q9C0D2
RTEFSFTDYSTKENV

COCH

416

O43405
VFGSVESSRDAQIKF

PNMA1

236

Q8ND90
LLENTFSEKQFFSEV

SACS

2046

Q9NZJ4
TIRTESSFQDTKISF

FABP9

51

Q0Z7S8
TLLRAFQAKFDTFVV

CFAP74

1186

Q9C0B2
FFRLFRSTVKQVDFS

SERPINE1

136

P05121
ASLFDAKERTVTFLS

NR1D2

451

Q14995
QDSFVFDIKTSERTF

GAB2

81

Q9UQC2
FISKEAQIRETETFS

RTN4

846

Q9NQC3
RSFTVATFRQEASLF

SPAAR

56

A0A1B0GVQ0
TADKTFFFQVICTTD

USH2A

4986

O75445
AKFTISEHTRINFFI

SPDYA

111

Q5MJ70
RFKSSARAIVFVVDS

SRPRB

131

Q9Y5M8
AQSSVVIFRFVEKAS

PSD

96

A5PKW4
ESIETVVTTFFTFAR

S100A13

11

Q99584
VVTTFFTFARQEGRK

S100A13

16

Q99584
VSTDRRDFFFASSFK

LGI2

516

Q8N0V4
VEFVELFKSFSVRSR

PLCE1

1216

Q9P212
FVFGSESVKRIFSSE

RGPD2

1531

P0DJD1
RLTRKDFFFIDVSSN

PKDREJ

1351

Q9NTG1
SSVLTAISKFDDFSR

MED24

76

O75448
ETGSFSKFVNVISAR

NAGPA

226

Q9UK23
FVTTATVDTSVKFSF

SIPA1L2

816

Q9P2F8
ARDTTSFEAFFQSKA

ST6GALNAC2

41

Q9UJ37
RSIDAFKDFVVASET

KITLG

146

P21583
TEEKFTILFESQFSV

STAT5B

436

P51692
ATTSLESFFQKAAER

POLH

476

Q9Y253
FQVSSKRFSAKEAFR

SLC25A42

61

Q86VD7
EVTFNITFDVDSKAS

ITGAM

876

P11215
AKFSRDFILISEFSE

SMCR8

51

Q8TEV9
TEEKFTVLFESQFSV

STAT5A

436

P42229
KDFSSVFQFLREEET

HIBADH

321

P31937
NSQFTAAVFKETFKS

ALG2

176

Q9H553
ASSRKEFSRSSLFFL

ARMCX1

406

Q9P291
SVRRFESFNLFSVTE

CAMKMT

61

Q7Z624
EEAFAIFRKFDVNTS

CLTC

1066

Q00610
AFFEFNSRLESILSK

CNGB1

771

Q14028
DVTNSRTFFAAKIVI

PROKR1

51

Q8TCW9
KSFIFTETQFTAVTA

TBX10

216

O75333
ESTSKEAFFSRVETF

ZC3HC1

71

Q86WB0
VFSSAEALVQSFRKV

UBE3A

156

Q05086
SFTDEQKRLFLQFTT

UBE3A

796

Q05086
FCFDNTFSTISEKVI

TMED5

106

Q9Y3A6
FSSKRSNVNFVTEIF

RALGAPA1

401

Q6GYQ0
AEFVFSVLVRESKAS

SEMA4G

216

Q9NTN9
FFTAKLSRSESDFSK

UNC13C

541

Q8NB66
STDRIDFFSALEKFV

SSH2

646

Q76I76
QDRAKSDTKSTAFSF

RYR3

306

Q15413
SFFESKESNTVFSFL

SH3BGRL2

81

Q9UJC5
FFQEMFETFTESRIV

TRPM2

386

O94759
IKVSTRSSEHFFSVF

TBC1D9

221

Q6ZT07
TEVFSTDFSNISAAK

SERPINA7

156

P05543
FFRSNKVFVESSETL

USP47

786

Q96K76
RDVKVSLFTAFFLAT

TMEM14A

51

Q9Y6G1
KTNTFVEFNFDSVTE

USP29

696

Q9HBJ7
IFTTSLNFVEKERDF

TTC3

381

P53804
FEGSEESFTFQVSTK

PIK3CD

196

O00329
SFFSAISEKKQEFTF

SERPINI2

91

O75830
FSAVTAFVTFRATRK

RNF121

111

Q9H920
FLIVFSVTDRRSFSK

REM2

191

Q8IYK8
RTQLVDTADKFRFFS

SPTB

1896

P11277
KRVSTFQEFESNTSD

TBC1D22A

56

Q8WUA7
TQVENFSTFIKCIFT

PKD2L1

501

Q9P0L9
TKFVSFEFSAQKNRS

PLCB2

556

Q00722
ESDSFVQQTFRSSKE

RSRC1

236

Q96IZ7
RTLVTFKDVFVDFTR

ZNF10

11

P21506
QVSVTFDDVAVTFTK

ZNF264

11

O43296
NIFSTKFTVETASRE

TOP2A

171

P11388
QASVSFEDVTVDFSK

ZNF41

66

P51814
VNSSFSELFVKFLET

TRIP11

1856

Q15643
KIASSFRDSSLFDIF

XPO7

176

Q9UIA9
ESVSFKDVTVDFSRD

ZNF484

6

Q5JVG2
QVFSEKLATDTSTFE

ZNF232

216

Q9UNY5
ISQASVSFKDVTIEF

ZNF510

41

Q9Y2H8
VFRNAASFKEVSDSL

PLIN2

356

Q99541
CFDNSFSTISEKLVF

TMED1

106

Q13445
QAERTAASTFKDFEL

TBC1D20

316

Q96BZ9
KTFVFEETRFTAVTA

TBX1

261

O43435
VASSVNTEFRRIDKF

TMEM129

141

A0AVI4
TNIVIDSDKTFFSIS

TRIM64C

366

A6NLI5
FQFTVERFSRLSESV

USP7

71

Q93009
FVTSTVKQEDSLFAS

YEATS2

546

Q9ULM3
SASFQEAVTFKDVIV

ZNF184

21

Q99676
NAAFTTVEESFKTLF

TRPC3

596

Q13507
QESVTFKDVSVDFTQ

ZFP90

11

Q8TF47
VSQVTKSVDFHFRTD

TPX2

251

Q9ULW0
SFLESVFKTEFVSLL

MYO1F

841

O00160
TIRTESTFKNTEISF

PMP2

51

P02689
REFISFVKTTVDNSF

GRIN2A

181

Q12879