Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR5P2 CCR2 PROKR1 OR52B4 OR8J3 GPR15 PROKR2 CXCR6 OR5G3 OR5L1 CYSLTR1 OR52E8 GPR87 ADGRF5 CCR7 OR8J1 OR5L2 OR2B6 GRM7 F2RL1 GRM8 ADCYAP1R1 OPRK1 OPRM1	1.17e-17	884	59	24	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR5P2 CCR2 PROKR1 OR52B4 OR8J3 GPR15 PROKR2 CXCR6 OR5G3 PTPRR OR5L1 CYSLTR1 OR52E8 GPR87 ADGRF5 CCR7 OR8J1 OR5L2 OR2B6 GRM7 F2RL1 GRM8 ADCYAP1R1 OPRK1 OPRM1	1.54e-14	1353	59	25	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	PROKR1 PROKR2 CYSLTR1 F2RL1 ADCYAP1R1 OPRK1 OPRM1	1.27e-07	133	59	7	GO:0008528
GeneOntologyMolecularFunction	peptide receptor activity	PROKR1 PROKR2 CYSLTR1 F2RL1 ADCYAP1R1 OPRK1 OPRM1	1.80e-07	140	59	7	GO:0001653
GeneOntologyMolecularFunction	odorant binding	OR5P2 OR8J3 OR5G3 OR5L1 OR8J1 OR5L2	2.01e-06	127	59	6	GO:0005549
GeneOntologyMolecularFunction	olfactory receptor activity	OR5P2 OR52B4 OR8J3 OR5G3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6	4.52e-06	431	59	9	GO:0004984
GeneOntologyMolecularFunction	C-C chemokine receptor activity	CCR2 CXCR6 CCR7	4.16e-05	23	59	3	GO:0016493
GeneOntologyMolecularFunction	C-C chemokine binding	CCR2 CXCR6 CCR7	4.75e-05	24	59	3	GO:0019957
GeneOntologyMolecularFunction	group III metabotropic glutamate receptor activity	GRM7 GRM8	5.13e-05	4	59	2	GO:0001642
GeneOntologyMolecularFunction	G protein-coupled chemoattractant receptor activity	CCR2 CXCR6 CCR7	6.07e-05	26	59	3	GO:0001637
GeneOntologyMolecularFunction	chemokine receptor activity	CCR2 CXCR6 CCR7	6.07e-05	26	59	3	GO:0004950
GeneOntologyMolecularFunction	chemokine binding	CCR2 CXCR6 CCR7	1.26e-04	33	59	3	GO:0019956
GeneOntologyMolecularFunction	neuropeptide binding	ADCYAP1R1 OPRK1 OPRM1	1.77e-04	37	59	3	GO:0042923
GeneOntologyMolecularFunction	G protein-coupled opioid receptor activity	OPRK1 OPRM1	1.79e-04	7	59	2	GO:0004985
GeneOntologyMolecularFunction	G protein-coupled glutamate receptor activity	GRM7 GRM8	3.05e-04	9	59	2	GO:0098988
GeneOntologyMolecularFunction	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	GRM7 GRM8	3.05e-04	9	59	2	GO:0001640
GeneOntologyMolecularFunction	monoatomic ion channel activity	KCNMB2 ANO9 PSEN1 KCNK13 GRM7 LRRC8D OPRM1	3.94e-04	459	59	7	GO:0005216
GeneOntologyMolecularFunction	neuropeptide Y receptor activity	PROKR1 PROKR2	4.64e-04	11	59	2	GO:0004983
GeneOntologyMolecularFunction	neuropeptide receptor activity	PROKR1 PROKR2 OPRM1	5.17e-04	53	59	3	GO:0008188
GeneOntologyMolecularFunction	channel activity	KCNMB2 ANO9 PSEN1 KCNK13 GRM7 LRRC8D OPRM1	8.72e-04	525	59	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	KCNMB2 ANO9 PSEN1 KCNK13 GRM7 LRRC8D OPRM1	8.82e-04	526	59	7	GO:0022803
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	KCNMB2 SLC9B1 ANO9 PSEN1 KCNK13 GRM7 LRRC8D OPRM1	2.21e-03	793	59	8	GO:0015075
GeneOntologyMolecularFunction	transmembrane transporter activity	KCNMB2 SLC7A8 SLC9B1 ANO9 PSEN1 ABCB6 KCNK13 GRM7 LRRC8D OPRM1	2.22e-03	1180	59	10	GO:0022857
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	KCNMB2 SLC9B1 PSEN1 KCNK13 GRM7 OPRM1	2.45e-03	465	59	6	GO:0046873
GeneOntologyMolecularFunction	G-protein beta-subunit binding	F2RL1 OPRM1	2.46e-03	25	59	2	GO:0031681
GeneOntologyMolecularFunction	glutamate receptor activity	GRM7 GRM8	2.87e-03	27	59	2	GO:0008066
GeneOntologyMolecularFunction	cytokine receptor activity	CCR2 CXCR6 CCR7	2.97e-03	97	59	3	GO:0004896
GeneOntologyMolecularFunction	gated channel activity	KCNMB2 ANO9 KCNK13 GRM7 OPRM1	3.04e-03	334	59	5	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	KCNMB2 PSEN1 KCNK13 GRM7 OPRM1	3.40e-03	343	59	5	GO:0005261
GeneOntologyMolecularFunction	transporter activity	KCNMB2 SLC7A8 SLC9B1 ANO9 PSEN1 ABCB6 KCNK13 GRM7 LRRC8D OPRM1	4.20e-03	1289	59	10	GO:0005215
GeneOntologyMolecularFunction	calcium channel activity	PSEN1 GRM7 OPRM1	6.58e-03	129	59	3	GO:0005262
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	KCNMB2 SLC9B1 ANO9 PSEN1 KCNK13 GRM7 OPRM1	6.79e-03	758	59	7	GO:0015318
GeneOntologyMolecularFunction	G-protein alpha-subunit binding	F2RL1 OPRM1	7.17e-03	43	59	2	GO:0001965
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	GRM7 OPRM1	8.17e-03	46	59	2	GO:0005245
GeneOntologyMolecularFunction	ion channel inhibitor activity	KCNMB2 ANO9	8.87e-03	48	59	2	GO:0008200
GeneOntologyMolecularFunction	channel inhibitor activity	KCNMB2 ANO9	9.60e-03	50	59	2	GO:0016248
GeneOntologyMolecularFunction	transporter inhibitor activity	KCNMB2 ANO9	9.97e-03	51	59	2	GO:0141110
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	PSEN1 GRM7 OPRM1	1.01e-02	151	59	3	GO:0015085
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	KCNMB2 SLC9B1 PSEN1 KCNK13 GRM7 OPRM1	1.03e-02	627	59	6	GO:0022890
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	KCNK13 GRM7 OPRM1	1.03e-02	152	59	3	GO:0022843
GeneOntologyMolecularFunction	cytokine binding	CCR2 CXCR6 CCR7	1.12e-02	157	59	3	GO:0019955
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR5P2 CCR2 PROKR1 OR52B4 OR8J3 GPR15 PROKR2 CXCR6 OR5G3 OR5L1 CYSLTR1 OR52E8 GPR87 ADGRF5 CCR7 OR8J1 OR5L2 OR2B6 GRM7 F2RL1 GRM8 ADCYAP1R1 OPRK1 OPRM1	1.50e-13	1395	59	24	GO:0007186
GeneOntologyBiologicalProcess	sensory perception	OR5P2 CCR2 OR52B4 OR8J3 OR5G3 OR5L1 OR52E8 PTGES OR8J1 MARVELD2 OR5L2 OR2B6 GRM7 GRM8 OPRK1 OPRM1	3.36e-08	1072	59	16	GO:0007600
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR5P2 KCNMB2 OR52B4 OR8J3 OR5G3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6	2.11e-06	524	59	10	GO:0009593
GeneOntologyBiologicalProcess	positive regulation of cytosolic calcium ion concentration	CCR2 CXCR6 CYSLTR1 CCR7 F2RL1 ADCYAP1R1 OPRM1	3.43e-06	224	59	7	GO:0007204
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR5P2 OR52B4 OR8J3 OR5G3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6	3.55e-06	432	59	9	GO:0050911
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR5P2 OR52B4 OR8J3 OR5G3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6 GRM8	5.36e-06	582	59	10	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR5P2 KCNMB2 OR52B4 OR8J3 OR5G3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6 GRM8	5.42e-06	722	59	11	GO:0051606
GeneOntologyBiologicalProcess	sensory perception of smell	OR5P2 OR52B4 OR8J3 OR5G3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6	6.44e-06	465	59	9	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR5P2 OR52B4 OR8J3 OR5G3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6	9.03e-06	485	59	9	GO:0050907
GeneOntologyBiologicalProcess	sensory perception of pain	CCR2 PTGES GRM8 OPRK1 OPRM1	1.25e-05	105	59	5	GO:0019233
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR5P2 OR52B4 OR8J3 OR5G3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6	2.34e-05	547	59	9	GO:0007606
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting opioid receptor signaling pathway	OPRK1 OPRM1	2.41e-05	3	59	2	GO:0031635
GeneOntologyBiologicalProcess	regulation of eosinophil degranulation	CCR2 F2RL1	2.41e-05	3	59	2	GO:0043309
GeneOntologyBiologicalProcess	neuropeptide signaling pathway	PROKR1 PROKR2 CYSLTR1 OPRK1 OPRM1	2.80e-05	124	59	5	GO:0007218
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	KCNMB2 CCR2 SLC9B1 ANO9 PSEN1 ABCB6 KCNK13 CCR7 LRRC8D ADCYAP1R1 OPRK1 OPRM1	6.20e-05	1115	59	12	GO:0034220
GeneOntologyBiologicalProcess	T cell activation involved in immune response	CCR2 PSEN1 CCR7 F2RL1 IFNA7	6.51e-05	148	59	5	GO:0002286
GeneOntologyBiologicalProcess	mature conventional dendritic cell differentiation	CCR7 F2RL1	8.00e-05	5	59	2	GO:0097029
GeneOntologyBiologicalProcess	positive regulation of thymocyte migration	CCR2 CCR7	8.00e-05	5	59	2	GO:2000412
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	GRM7 GRM8 OPRK1 OPRM1	1.08e-04	86	59	4	GO:0007193
GeneOntologyBiologicalProcess	monoatomic ion transport	KCNMB2 CCR2 SLC9B1 ANO9 PSEN1 CYSLTR1 ABCB6 KCNK13 CCR7 LRRC8D ADCYAP1R1 OPRK1 OPRM1	1.09e-04	1374	59	13	GO:0006811
GeneOntologyBiologicalProcess	regulation of thymocyte migration	CCR2 CCR7	1.20e-04	6	59	2	GO:2000410
GeneOntologyBiologicalProcess	negative regulation of luteinizing hormone secretion	OPRK1 OPRM1	1.20e-04	6	59	2	GO:0033685
GeneOntologyBiologicalProcess	regulation of synaptic transmission, glutamatergic	CCR2 PSEN1 GRM7 GRM8	1.40e-04	92	59	4	GO:0051966
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ADGRF5 GRM7 GRM8 ADCYAP1R1 OPRK1 OPRM1	1.64e-04	286	59	6	GO:0007188
GeneOntologyBiologicalProcess	eosinophil activation involved in immune response	CCR2 F2RL1	2.86e-04	9	59	2	GO:0002278
GeneOntologyBiologicalProcess	thymocyte migration	CCR2 CCR7	2.86e-04	9	59	2	GO:0072679
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	GRM7 GRM8	2.86e-04	9	59	2	GO:0007196
GeneOntologyBiologicalProcess	eosinophil degranulation	CCR2 F2RL1	2.86e-04	9	59	2	GO:0043308
GeneOntologyBiologicalProcess	positive regulation of T-helper 1 cell differentiation	CCR2 CCR7	2.86e-04	9	59	2	GO:0045627
GeneOntologyBiologicalProcess	myeloid leukocyte activation	CCR2 PSEN1 LRFN5 ENPP3 ADGRF5 F2RL1	3.00e-04	320	59	6	GO:0002274
GeneOntologyBiologicalProcess	eosinophil activation	CCR2 F2RL1	3.57e-04	10	59	2	GO:0043307
GeneOntologyBiologicalProcess	eosinophil mediated immunity	CCR2 F2RL1	3.57e-04	10	59	2	GO:0002447
GeneOntologyBiologicalProcess	regulation of luteinizing hormone secretion	OPRK1 OPRM1	3.57e-04	10	59	2	GO:0033684
GeneOntologyBiologicalProcess	negative regulation of secretion by cell	CCR2 GRM7 F2RL1 OPRK1 OPRM1	3.64e-04	214	59	5	GO:1903531
GeneOntologyBiologicalProcess	negative regulation of gonadotropin secretion	OPRK1 OPRM1	4.35e-04	11	59	2	GO:0032277
GeneOntologyBiologicalProcess	metal ion transport	KCNMB2 SLC9B1 PSEN1 CYSLTR1 ABCB6 KCNK13 CCR7 ADCYAP1R1 OPRK1 OPRM1	4.95e-04	1000	59	10	GO:0030001
GeneOntologyBiologicalProcess	dendritic cell differentiation	PSEN1 CCR7 F2RL1	4.97e-04	54	59	3	GO:0097028
GeneOntologyBiologicalProcess	synaptic transmission, glutamatergic	CCR2 PSEN1 GRM7 GRM8	5.55e-04	132	59	4	GO:0035249
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	KCNMB2 SLC9B1 ANO9 PSEN1 ABCB6 KCNK13 CCR7 ADCYAP1R1 OPRK1 OPRM1	5.64e-04	1017	59	10	GO:0098660
GeneOntologyBiologicalProcess	leukocyte activation involved in immune response	CCR2 PSEN1 ENPP3 CCR7 F2RL1 IFNA7	5.69e-04	361	59	6	GO:0002366
GeneOntologyBiologicalProcess	cell activation involved in immune response	CCR2 PSEN1 ENPP3 CCR7 F2RL1 IFNA7	6.03e-04	365	59	6	GO:0002263
GeneOntologyBiologicalProcess	negative regulation of secretion	CCR2 GRM7 F2RL1 OPRK1 OPRM1	6.03e-04	239	59	5	GO:0051048
GeneOntologyBiologicalProcess	granulocyte activation	CCR2 ENPP3 F2RL1	6.13e-04	58	59	3	GO:0036230
GeneOntologyBiologicalProcess	positive regulation of pseudopodium assembly	CCR7 F2RL1	6.15e-04	13	59	2	GO:0031274
GeneOntologyBiologicalProcess	regulation of pseudopodium assembly	CCR7 F2RL1	6.15e-04	13	59	2	GO:0031272
GeneOntologyBiologicalProcess	G protein-coupled opioid receptor signaling pathway	OPRK1 OPRM1	6.15e-04	13	59	2	GO:0038003
GeneOntologyBiologicalProcess	inflammatory response	MEP1B CCR2 PSEN1 CXCR6 LRFN5 CYSLTR1 ENPP3 PTGES CCR7 F2RL1	6.86e-04	1043	59	10	GO:0006954
GeneOntologyBiologicalProcess	regulation of endocrine process	F2RL1 OPRK1 OPRM1	7.11e-04	61	59	3	GO:0044060
GeneOntologyBiologicalProcess	luteinizing hormone secretion	OPRK1 OPRM1	7.16e-04	14	59	2	GO:0032275
GeneOntologyBiologicalProcess	regulation of T-helper 1 cell differentiation	CCR2 CCR7	7.16e-04	14	59	2	GO:0045625
GeneOntologyBiologicalProcess	lymphocyte activation involved in immune response	CCR2 PSEN1 CCR7 F2RL1 IFNA7	7.51e-04	251	59	5	GO:0002285
GeneOntologyBiologicalProcess	presynaptic modulation of chemical synaptic transmission	GRM7 GRM8 OPRM1	9.35e-04	67	59	3	GO:0099171
GeneOntologyBiologicalProcess	positive regulation of T cell chemotaxis	CCR2 CCR7	9.41e-04	16	59	2	GO:0010820
GeneOntologyBiologicalProcess	G protein-coupled glutamate receptor signaling pathway	GRM7 GRM8	9.41e-04	16	59	2	GO:0007216
GeneOntologyBiologicalProcess	regulation of gonadotropin secretion	OPRK1 OPRM1	9.41e-04	16	59	2	GO:0032276
GeneOntologyBiologicalProcess	pseudopodium assembly	CCR7 F2RL1	1.06e-03	17	59	2	GO:0031269
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	KCNMB2 SLC9B1 PSEN1 ABCB6 KCNK13 CCR7 ADCYAP1R1 OPRK1 OPRM1	1.15e-03	922	59	9	GO:0098662
GeneOntologyBiologicalProcess	negative regulation of adenylate cyclase activity	CCR2 GPR87	1.19e-03	18	59	2	GO:0007194
GeneOntologyBiologicalProcess	regulation of NMDA receptor activity	CCR2 OPRM1	1.19e-03	18	59	2	GO:2000310
GeneOntologyBiologicalProcess	pseudopodium organization	CCR7 F2RL1	1.33e-03	19	59	2	GO:0031268
GeneOntologyBiologicalProcess	negative regulation of cyclase activity	CCR2 GPR87	1.33e-03	19	59	2	GO:0031280
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	KCNMB2 SLC9B1 PSEN1 ABCB6 KCNK13 CCR7 ADCYAP1R1 OPRK1 OPRM1	1.34e-03	942	59	9	GO:0098655
GeneOntologyBiologicalProcess	regulation of T cell chemotaxis	CCR2 CCR7	1.48e-03	20	59	2	GO:0010819
GeneOntologyBiologicalProcess	negative regulation of macrophage activation	LRFN5 ADGRF5	1.48e-03	20	59	2	GO:0043031
GeneOntologyBiologicalProcess	monoatomic cation transport	KCNMB2 SLC9B1 PSEN1 CYSLTR1 ABCB6 KCNK13 CCR7 ADCYAP1R1 OPRK1 OPRM1	1.51e-03	1157	59	10	GO:0006812
GeneOntologyBiologicalProcess	T cell migration	CCR2 GPR15 CCR7	1.62e-03	81	59	3	GO:0072678
GeneOntologyBiologicalProcess	negative regulation of lyase activity	CCR2 GPR87	1.79e-03	22	59	2	GO:0051350
GeneOntologyBiologicalProcess	positive regulation of lymphocyte chemotaxis	CCR2 CCR7	1.79e-03	22	59	2	GO:0140131
GeneOntologyBiologicalProcess	gonadotropin secretion	OPRK1 OPRM1	1.79e-03	22	59	2	GO:0032274
GeneOntologyCellularComponent	presynaptic membrane	PSEN1 GRM7 GRM8 DENND1A OPRK1 OPRM1	1.28e-04	277	59	6	GO:0042734
GeneOntologyCellularComponent	synaptic membrane	LRFN2 PSEN1 LRFN5 GRM7 GRM8 DENND1A OPRK1 OPRM1	2.21e-04	583	59	8	GO:0097060
MousePheno	abnormal hypersensitivity reaction	CCR2 CYSLTR1 ENPP3 PTGES CCR7 F2RL1	2.40e-05	174	47	6	MP:0002148
MousePheno	abnormal associative learning	CCR2 LRFN2 PSEN1 G2E3 GRM7 ADCYAP1R1 OPRK1 OPRM1	4.37e-05	393	47	8	MP:0002062
MousePheno	abnormal intromission	GRM7 OPRM1	1.10e-04	5	47	2	MP:0031628
MousePheno	impaired behavioral response to anesthetic	OPRK1 OPRM1	1.10e-04	5	47	2	MP:0009778
MousePheno	abnormal type I hypersensitivity reaction	CCR2 CYSLTR1 ENPP3 PTGES	1.78e-04	84	47	4	MP:0002531
MousePheno	decreased capillary density	PROKR1 PSEN1	2.30e-04	7	47	2	MP:0020329
MousePheno	abnormal touch/ nociception	PROKR1 PSEN1 PTGES GRM7 F2RL1 OPRK1 OPRM1	2.40e-04	376	47	7	MP:0001968
MousePheno	abnormal pain threshold	PROKR1 PTGES GRM7 F2RL1 OPRK1 OPRM1	2.55e-04	267	47	6	MP:0001970
MousePheno	abnormal bone marrow cell physiology	GPR15 NBEAL2 OPRM1	3.73e-04	42	47	3	MP:0009278
MousePheno	abnormal capillary density	PROKR1 PSEN1	3.92e-04	9	47	2	MP:0020328
MousePheno	decreased CD11b-high dendritic cell number	CCR2 CCR7	3.92e-04	9	47	2	MP:0013649
MousePheno	decreased susceptibility to injury	MEP1B CCR2 SCGB3A2 NBEAL2 F2RL1	4.67e-04	194	47	5	MP:0005166
MousePheno	decreased inflammatory response	MEP1B CCR2 CYSLTR1 PTGES CCR7 F2RL1	4.76e-04	300	47	6	MP:0001876
MousePheno	impaired behavioral response to morphine	OPRK1 OPRM1	4.89e-04	10	47	2	MP:0009757
Domain	GPCR_Rhodpsn_7TM	OR5P2 CCR2 PROKR1 OR52B4 OR8J3 GPR15 PROKR2 CXCR6 OR5L1 CYSLTR1 OR52E8 GPR87 CCR7 OR8J1 OR5L2 OR2B6 F2RL1 OPRK1 OPRM1	9.84e-14	670	59	19	IPR017452
Domain	7tm_1	OR5P2 CCR2 PROKR1 OR52B4 OR8J3 GPR15 PROKR2 CXCR6 OR5L1 CYSLTR1 OR52E8 GPR87 CCR7 OR8J1 OR5L2 OR2B6 F2RL1 OPRK1 OPRM1	1.18e-13	677	59	19	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR5P2 CCR2 PROKR1 OR52B4 OR8J3 GPR15 PROKR2 CXCR6 OR5L1 CYSLTR1 OR52E8 GPR87 CCR7 OR8J1 OR5L2 OR2B6 F2RL1 OPRK1 OPRM1	1.46e-13	685	59	19	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR5P2 CCR2 PROKR1 OR52B4 OR8J3 GPR15 PROKR2 CXCR6 OR5L1 CYSLTR1 OR52E8 GPR87 CCR7 OR8J1 OR5L2 OR2B6 F2RL1 OPRK1 OPRM1	1.71e-13	691	59	19	PS50262
Domain	GPCR_Rhodpsn	OR5P2 CCR2 PROKR1 OR52B4 OR8J3 GPR15 PROKR2 CXCR6 OR5L1 CYSLTR1 OR52E8 GPR87 CCR7 OR8J1 OR5L2 OR2B6 F2RL1 OPRK1 OPRM1	1.75e-13	692	59	19	IPR000276
Domain	Chemokine_rcpt	CCR2 CXCR6 CCR7	1.63e-05	16	59	3	IPR000355
Domain	Olfact_rcpt	OR5P2 OR52B4 OR8J3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6	3.11e-05	393	59	8	IPR000725
Domain	Opioid_rcpt	OPRK1 OPRM1	5.86e-05	4	59	2	IPR001418
Domain	GPCR_3_mtglu_rcpt	GRM7 GRM8	2.71e-04	8	59	2	IPR000162
Domain	NPY_rcpt	PROKR1 PROKR2	3.48e-04	9	59	2	IPR000611
Domain	NCD3G	GRM7 GRM8	7.48e-04	13	59	2	PF07562
Domain	GPCR_3_9-Cys_dom	GRM7 GRM8	7.48e-04	13	59	2	IPR011500
Domain	GPCR_3_CS	GRM7 GRM8	8.71e-04	14	59	2	IPR017979
Domain	GPCR_3	GRM7 GRM8	1.98e-03	21	59	2	IPR000337
Domain	G_PROTEIN_RECEP_F3_4	GRM7 GRM8	2.18e-03	22	59	2	PS50259
Domain	7tm_3	GRM7 GRM8	2.18e-03	22	59	2	PF00003
Domain	GPCR_3_C	GRM7 GRM8	2.18e-03	22	59	2	IPR017978
Domain	G_PROTEIN_RECEP_F3_2	GRM7 GRM8	2.18e-03	22	59	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM7 GRM8	2.18e-03	22	59	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM7 GRM8	2.18e-03	22	59	2	PS00979
Domain	GPCR_2_secretin-like_CS	ADGRF5 ADCYAP1R1	5.16e-03	34	59	2	IPR017983
Domain	7TM_GPCR_Srsx	CCR2 GPR15 OPRK1	5.35e-03	112	59	3	SM01381
Domain	ANF_receptor	GRM7 GRM8	6.09e-03	37	59	2	PF01094
Domain	ANF_lig-bd_rcpt	GRM7 GRM8	6.09e-03	37	59	2	IPR001828
Domain	Peripla_BP_I	GRM7 GRM8	6.74e-03	39	59	2	IPR028082
Domain	G_PROTEIN_RECEP_F2_1	ADGRF5 ADCYAP1R1	7.08e-03	40	59	2	PS00649
Domain	G_PROTEIN_RECEP_F2_3	ADGRF5 ADCYAP1R1	7.08e-03	40	59	2	PS50227
Domain	GPCR_2_extracellular_dom	ADGRF5 ADCYAP1R1	7.08e-03	40	59	2	IPR001879
Domain	G_PROTEIN_RECEP_F2_2	ADGRF5 ADCYAP1R1	1.09e-02	50	59	2	PS00650
Domain	7tm_2	ADGRF5 ADCYAP1R1	1.09e-02	50	59	2	PF00002
Pathway	WP_GPCRS_NONODORANT	CCR2 PROKR1 GPR15 PROKR2 CXCR6 CYSLTR1 CCR7 GRM7 F2RL1 GRM8 ADCYAP1R1 OPRK1 OPRM1	4.11e-12	266	49	13	MM15843
Pathway	REACTOME_GPCR_LIGAND_BINDING	CCR2 PROKR1 PROKR2 CXCR6 CYSLTR1 CCR7 GRM7 F2RL1 GRM8 ADCYAP1R1 OPRK1 OPRM1	4.18e-08	463	49	12	M507
Pathway	REACTOME_GPCR_LIGAND_BINDING	PROKR1 PROKR2 CXCR6 CYSLTR1 CCR7 GRM7 F2RL1 GRM8 ADCYAP1R1 OPRK1 OPRM1	1.92e-07	430	49	11	MM15160
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	CCR2 GPR15 CYSLTR1 GPR87 CCR7 OR2B6 F2RL1 OPRK1 OPRM1	2.32e-07	260	49	9	M39397
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	CCR2 PROKR1 PROKR2 CXCR6 CCR7 F2RL1 OPRK1 OPRM1	3.48e-07	197	49	8	M12289
Pathway	REACTOME_SIGNALING_BY_GPCR	CCR2 PROKR1 GPR15 PROKR2 CXCR6 CYSLTR1 CCR7 GRM7 F2RL1 GRM8 ADCYAP1R1 OPRK1 OPRM1	5.16e-07	702	49	13	M746
Pathway	WP_GPCRS_OTHER	PROKR1 CYSLTR1 CCR7 OR2B6 OPRK1 OPRM1	9.41e-07	96	49	6	MM15939
Pathway	REACTOME_SIGNALING_BY_GPCR	PROKR1 GPR15 PROKR2 CXCR6 CYSLTR1 CCR7 GRM7 F2RL1 GRM8 ADCYAP1R1 OPRK1 OPRM1	1.50e-06	646	49	12	MM14962
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	CCR2 PROKR1 PROKR2 CXCR6 CYSLTR1 CCR7 F2RL1 OPRK1 OPRM1	1.70e-06	330	49	9	M18334
Pathway	WP_GPCRS_PEPTIDE	CCR2 CXCR6 CCR7 OPRK1 OPRM1	4.20e-06	70	49	5	MM15959
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	PROKR1 PROKR2 CXCR6 CCR7 F2RL1 OPRK1 OPRM1	4.89e-06	197	49	7	MM14970
Pathway	WP_PEPTIDE_GPCRS	CCR2 CXCR6 CCR7 OPRK1 OPRM1	5.92e-06	75	49	5	M39696
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	PROKR1 PROKR2 CXCR6 CYSLTR1 CCR7 F2RL1 OPRK1 OPRM1	1.73e-05	333	49	8	MM14963
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	CYSLTR1 GRM7 F2RL1 GRM8 ADCYAP1R1 OPRK1 OPRM1	3.96e-05	272	49	7	M13380
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	CCR2 CYSLTR1 GPR87 F2RL1 OPRK1 OPRM1	4.25e-05	186	49	6	MM15994
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR5P2 OR52B4 OR8J3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6	5.24e-05	389	49	8	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR5P2 OR8J3 OR5G3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6	8.53e-05	417	49	8	M4072
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	CCR2 CXCR6 CCR7 GRM7 GRM8 OPRK1 OPRM1	9.79e-05	314	49	7	M600
Pathway	WP_GPCRS_OTHER	PROKR2 ADGRF5 OR2B6 GRM8	3.00e-04	93	49	4	M39629
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PROK2_TO_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY	PROKR1 PROKR2	3.27e-04	8	49	2	M47642
Pathway	KEGG_MEDICUS_REFERENCE_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY	PROKR1 PROKR2	4.20e-04	9	49	2	M47641
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	CXCR6 CCR7 GRM7 GRM8 OPRK1 OPRM1	4.70e-04	289	49	6	MM15057
Pathway	REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES	CCR2 CXCR6 CCR7	1.01e-03	57	49	3	M625
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	GRM7 GRM8	1.21e-03	15	49	2	M39442
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	GRM7 GRM8	1.21e-03	15	49	2	MM15845
Pathway	REACTOME_SENSORY_PERCEPTION	OR5P2 OR8J3 OR5G3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6	1.44e-03	636	49	8	M41834
Pathway	REACTOME_MECP2_REGULATES_NEURONAL_RECEPTORS_AND_CHANNELS	OPRK1 OPRM1	1.75e-03	18	49	2	M27901
Pathway	WP_GPCRS_ODORANT	OR5P2 GPR87 ADGRF5 OR2B6	2.12e-03	157	49	4	MM15872
Pathway	BIOCARTA_EICOSANOID_PATHWAY	CYSLTR1 PTGES	2.16e-03	20	49	2	MM1529
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR5P2 OR52B4 OR8J3 OR5G3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6	7.00e-09	340	60	9	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR5P2 OR52B4 OR8J3 OR5G3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6	7.00e-09	340	60	9	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR5P2 OR52B4 OR8J3 OR5G3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6	7.55e-09	343	60	9	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR5P2 OR52B4 OR8J3 OR5G3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6	8.14e-09	346	60	9	14611657
Pubmed	Evidence of extended alternate coreceptor usage by HIV-1 clade C envelope obtained from an Indian patient.	CCR2 GPR15 CXCR6	9.73e-08	6	60	3	22086059
Pubmed	Use of alternate coreceptors on primary cells by two HIV-1 isolates.	CCR2 GPR15 CXCR6	1.70e-07	7	60	3	15992849
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	GRM7 GRM8 ADCYAP1R1 OPRK1 OPRM1	2.99e-07	81	60	5	22723691
Pubmed	The human olfactory receptor gene family.	OR5P2 OR52B4 OR8J3 OR5G3 OR5L1 OR52E8 OR8J1 OR5L2 OR2B6	3.65e-07	541	60	9	14983052
Pubmed	Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.	CCR2 CXCR6 CCR7	4.07e-07	9	60	3	12070001
Pubmed	Dissociation of heterotrimeric g proteins in cells.	CCR2 CXCR6 CCR7 ADCYAP1R1 OPRK1 OPRM1	6.79e-07	179	60	6	18577758
Pubmed	Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.	CCR2 CXCR6 CCR7 ADCYAP1R1 OPRK1 OPRM1	1.30e-06	200	60	6	18240029
Pubmed	κ Opioid Receptor 1 Single Nucleotide Polymorphisms were Associated with the Methadone Dosage.	OPRK1 OPRM1	2.93e-06	2	60	2	31940240
Pubmed	Differential involvement of the mu and kappa opioid receptors in spatial learning.	OPRK1 OPRM1	2.93e-06	2	60	2	12884965
Pubmed	Involvement of µ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice.	OPRK1 OPRM1	2.93e-06	2	60	2	28512665
Pubmed	Expression of prokineticin receptors in mouse cultured astrocytes and involvement in cell proliferation.	PROKR1 PROKR2	2.93e-06	2	60	2	16901473
Pubmed	C-C motif chemokine receptor 2 and 7 synergistically control inflammatory monocyte recruitment but the infecting virus dictates monocyte function in the brain.	CCR2 CCR7	2.93e-06	2	60	2	38658802
Pubmed	Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus.	GRM7 GRM8	2.93e-06	2	60	2	23220400
Pubmed	Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor.	PROKR1 PROKR2	2.93e-06	2	60	2	11886876
Pubmed	Mu- and kappa-opioids induce the differentiation of embryonic stem cells to neural progenitors.	OPRK1 OPRM1	2.93e-06	2	60	2	16954126
Pubmed	No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals.	GRM7 GRM8	2.93e-06	2	60	2	11912074
Pubmed	Significant association of GRM7 and GRM8 genes with schizophrenia and major depressive disorder in the Han Chinese population.	GRM7 GRM8	2.93e-06	2	60	2	26655190
Pubmed	Deletion of mu- and kappa-opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings, and itch behavior.	OPRK1 OPRM1	2.93e-06	2	60	2	17185983
Pubmed	Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations.	PSEN1 F2RL1	2.93e-06	2	60	2	27143420
Pubmed	Differential stability of the crystallographic interfaces of mu- and kappa-opioid receptors.	OPRK1 OPRM1	2.93e-06	2	60	2	24651466
Pubmed	Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss.	PROKR1 PROKR2	2.93e-06	2	60	2	26984842
Pubmed	Morphine can produce analgesia via spinal kappa opioid receptors in the absence of mu opioid receptors.	OPRK1 OPRM1	2.93e-06	2	60	2	16530171
Pubmed	Association of OPRK1 and OPRM1 methylation with mild cognitive impairment in Xinjiang Han and Uygur populations.	OPRK1 OPRM1	2.93e-06	2	60	2	27838450
Pubmed	Differential roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and physiology.	GRM7 GRM8	2.93e-06	2	60	2	23664812
Pubmed	Epistatic effects between variants of kappa-opioid receptor gene and A118G of mu-opioid receptor gene increase susceptibility to addiction in Indian population.	OPRK1 OPRM1	2.93e-06	2	60	2	22138325
Pubmed	Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs.	PROKR1 PROKR2	2.93e-06	2	60	2	22132188
Pubmed	Prokineticin receptor variants (PKR1-I379V and PKR2-V331M) are protective genotypes in human early pregnancy.	PROKR1 PROKR2	2.93e-06	2	60	2	23687280
Pubmed	Opioid Receptors in Psoriatic Skin: Relationship with Itch.	OPRK1 OPRM1	2.93e-06	2	60	2	27958613
Pubmed	Ligand directed signaling differences between rodent and human κ-opioid receptors.	OPRK1 OPRM1	2.93e-06	2	60	2	23086943
Pubmed	Expression cloning of new receptors used by simian and human immunodeficiency viruses.	GPR15 CXCR6	2.93e-06	2	60	2	9230441
Pubmed	CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization.	CCR2 CCR7	2.93e-06	2	60	2	22262658
Pubmed	Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.	CCR2 PSEN1 CCR7	3.91e-06	18	60	3	23913046
Pubmed	Use of (alternative) coreceptors for HIV entry.	CCR2 CXCR6 CCR7	6.35e-06	21	60	3	22842622
Pubmed	Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*.	OPRK1 OPRM1	8.77e-06	3	60	2	19032295
Pubmed	The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice.	OPRK1 OPRM1	8.77e-06	3	60	2	15090050
Pubmed	The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain.	PROKR1 PROKR2	8.77e-06	3	60	2	19667192
Pubmed	Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice.	OPRK1 OPRM1	8.77e-06	3	60	2	10082819
Pubmed	Cell-specific actions of HIV-Tat and morphine on opioid receptor expression in glia.	OPRK1 OPRM1	8.77e-06	3	60	2	18338799
Pubmed	Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers.	OPRK1 OPRM1	8.77e-06	3	60	2	18537939
Pubmed	Food reward-sensitive interaction of ghrelin and opioid receptor pathways in mesolimbic dopamine system.	OPRK1 OPRM1	8.77e-06	3	60	2	23220294
Pubmed	Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones.	OPRK1 OPRM1	8.77e-06	3	60	2	12603260
Pubmed	Long-term alterations in mu, delta and kappa opioidergic receptors following middle cerebral artery occlusion in mice.	OPRK1 OPRM1	8.77e-06	3	60	2	17676326
Pubmed	Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms.	OPRK1 OPRM1	8.77e-06	3	60	2	26692286
Pubmed	Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study.	OPRK1 OPRM1	8.77e-06	3	60	2	17374034
Pubmed	Placental expression of EG-VEGF and its receptors PKR1 (prokineticin receptor-1) and PKR2 throughout mouse gestation.	PROKR1 PROKR2	8.77e-06	3	60	2	17531315
Pubmed	Genetic Variations of OPRM1, OPRK1, and COMT Genes and Their Possible Associations with Oral Pain in a Population from Argentina.	OPRK1 OPRM1	8.77e-06	3	60	2	30365572
Pubmed	Quantitative trait loci influencing morphine antinociception in four mapping populations.	OPRK1 OPRM1	8.77e-06	3	60	2	11420618
Pubmed	Immunosuppression by delta-opioid antagonist naltrindole: delta- and triple mu/delta/kappa-opioid receptor knockout mice reveal a nonopioid activity.	OPRK1 OPRM1	8.77e-06	3	60	2	11504820
Pubmed	No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse.	OPRK1 OPRM1	8.77e-06	3	60	2	15178356
Pubmed	Autoradiography of opioid and ORL1 ligands in opioid receptor triple knockout mice.	OPRK1 OPRM1	8.77e-06	3	60	2	12431223
Pubmed	Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C.	OPRK1 OPRM1	8.77e-06	3	60	2	9572309
Pubmed	The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation.	OPRK1 OPRM1	8.77e-06	3	60	2	28049031
Pubmed	Revisiting the role of hCG: new regulation of the angiogenic factor EG-VEGF and its receptors.	PROKR1 PROKR2	8.77e-06	3	60	2	22138749
Pubmed	Antagonism of the Prokineticin System Prevents and Reverses Allodynia and Inflammation in a Mouse Model of Diabetes.	PROKR1 PROKR2	8.77e-06	3	60	2	26730729
Pubmed	Formalin-induced pain is reduced in sigma(1) receptor knockout mice.	OPRK1 OPRM1	8.77e-06	3	60	2	15777781
Pubmed	Biased signaling at chemokine receptors.	CCR2 CCR7	8.77e-06	3	60	2	25614627
Pubmed	Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.	GRM7 GRM8	8.77e-06	3	60	2	33068816
Pubmed	CCR5, GPR15, and CXCR6 are major coreceptors of human immunodeficiency virus type 2 variants isolated from individuals with and without plasma viremia.	GPR15 CXCR6	8.77e-06	3	60	2	15650194
Pubmed	Modelling the PKPD of oxycodone in experimental pain - Impact of opioid receptor polymorphisms.	OPRK1 OPRM1	8.77e-06	3	60	2	26946441
Pubmed	OPRM1, OPRK1, and COMT genetic polymorphisms associated with opioid effects on experimental pain: a randomized, double-blind, placebo-controlled study.	OPRK1 OPRM1	8.77e-06	3	60	2	31806881
Pubmed	Nociception increases during opioid infusion in opioid receptor triple knock-out mice.	OPRK1 OPRM1	8.77e-06	3	60	2	17544222
Pubmed	Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han.	OPRK1 OPRM1	8.77e-06	3	60	2	14745298
Pubmed	iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation.	CCR2 CXCR6	8.77e-06	3	60	2	27653688
Pubmed	Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration.	PROKR1 PROKR2	8.77e-06	3	60	2	20023120
Pubmed	Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.	OPRK1 OPRM1	8.77e-06	3	60	2	8114680
Pubmed	Opioid receptor characterisation of neuronally stimulated isolated human vas deferens.	OPRK1 OPRM1	8.77e-06	3	60	2	22752269
Pubmed	Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice.	OPRK1 OPRM1	8.77e-06	3	60	2	11032994
Pubmed	Systemic morphine treatment derails normal uterine receptivity, leading to embryo implantation failure in mice.	OPRK1 OPRM1	8.77e-06	3	60	2	25855262
Pubmed	Opioid receptors: from binding sites to visible molecules in vivo.	OPRK1 OPRM1	8.77e-06	3	60	2	18718480
Pubmed	Polymorphisms of endocrine gland-derived vascular endothelial growth factor gene and its receptor genes are associated with recurrent pregnancy loss.	PROKR1 PROKR2	8.77e-06	3	60	2	20847187
Pubmed	Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence.	OPRK1 OPRM1	8.77e-06	3	60	2	24874714
Pubmed	The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes.	CCR2 GPR15	8.77e-06	3	60	2	10985245
Pubmed	Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.	GRM7 GRM8	8.77e-06	3	60	2	9473604
Pubmed	Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin.	CCR2 CCR7	8.77e-06	3	60	2	24184057
Pubmed	Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.	PROKR1 PROKR2	8.77e-06	3	60	2	33811988
Pubmed	Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors.	OPRK1 OPRM1	8.77e-06	3	60	2	11826143
Pubmed	Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations.	OPRK1 OPRM1	8.77e-06	3	60	2	18213616
Pubmed	Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.	OPRK1 OPRM1	8.77e-06	3	60	2	33555255
Pubmed	Enhanced humoral response in kappa-opioid receptor knockout mice.	OPRK1 OPRM1	8.77e-06	3	60	2	12507774
Pubmed	Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock-out mice: effects of chronic morphine administration.	OPRK1 OPRM1	8.77e-06	3	60	2	14975676
Pubmed	Gene-gene interactions and risk of recurrent miscarriages in carriers of endocrine gland-derived vascular endothelial growth factor and prokineticin receptor polymorphisms.	PROKR1 PROKR2	8.77e-06	3	60	2	25064403
Pubmed	Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.	OPRK1 OPRM1	8.77e-06	3	60	2	11069979
Pubmed	Adoptive cell therapy with tumor-specific Th9 cells induces viral mimicry to eliminate antigen-loss-variant tumor cells.	CCR2 CXCR6 CCR7	1.73e-05	29	60	3	34678150
Pubmed	Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle.	PROKR1 PROKR2	1.75e-05	4	60	2	15126578
Pubmed	The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells.	PROKR1 PROKR2	1.75e-05	4	60	2	12604792
Pubmed	Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia.	OPRK1 OPRM1	1.75e-05	4	60	2	17997230
Pubmed	Multiple opioid receptor-like genes are identified in diverse vertebrate phyla.	OPRK1 OPRM1	1.75e-05	4	60	2	8941707
Pubmed	Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12.	CCR2 CCR7	1.75e-05	4	60	2	28729715
Pubmed	Abnormal Pain Sensation in Mice Lacking the Prokineticin Receptor PKR2: Interaction of PKR2 with Transient Receptor Potential TRPV1 and TRPA1.	PROKR1 PROKR2	1.75e-05	4	60	2	31883821
Pubmed	Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells.	OPRK1 OPRM1	1.75e-05	4	60	2	12413885
Pubmed	Migratory properties of pulmonary dendritic cells are determined by their developmental lineage.	CCR2 CCR7	1.75e-05	4	60	2	23168837
Pubmed	Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation.	CCR2 CCR7	1.75e-05	4	60	2	10741397
Pubmed	Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse.	OPRK1 OPRM1	1.75e-05	4	60	2	9502813
Pubmed	Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen.	CCR2 CCR7	1.75e-05	4	60	2	23352232
Pubmed	The SALM/Lrfn family of leucine-rich repeat-containing cell adhesion molecules.	LRFN2 LRFN5	1.75e-05	4	60	2	21736948
Pubmed	Prokineticins in central and peripheral control of human reproduction.	PROKR1 PROKR2	1.75e-05	4	60	2	26574895
Interaction	GPRASP1 interactions	F2RL1 GRM8 OPRK1 OPRM1	2.29e-05	67	50	4	int:GPRASP1
Interaction	AUP1 interactions	PEX3 ABCB6 RNF139 F2RL1 OPRK1 OPRM1	2.38e-05	234	50	6	int:AUP1
Cytoband	Ensembl 112 genes in cytogenetic band chr11q12	OR8J3 OR5G3 OR5L1 OR8J1 OR5L2	9.06e-05	345	60	5	chr11q12
Cytoband	3p21.31	CCR2 NBEAL2 CDCP1	3.14e-04	100	60	3	3p21.31
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	CCR2 CXCR6 NBEAL2 CDCP1	7.93e-04	316	60	4	chr3p21
Cytoband	11q12.1	OR8J3 OR5G3 OR8J1	1.25e-03	161	60	3	11q12.1
Cytoband	11q11	OR5L1 OR5L2	1.75e-03	47	60	2	11q11
Cytoband	11p15.4	OR5P2 OR52B4 OR52E8	2.32e-03	200	60	3	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR5P2 OR52B4 ANO9 OR52E8	6.39e-03	564	60	4	chr11p15
GeneFamily	Prokineticin receptors	PROKR1 PROKR2	8.43e-06	2	53	2	216
GeneFamily	Opioid receptors	OPRK1 OPRM1	5.04e-05	4	53	2	245
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM7 GRM8	2.33e-04	8	53	2	281
GeneFamily	Olfactory receptors, family 5	OR5P2 OR5G3 OR5L1 OR5L2	3.23e-04	112	53	4	152
GeneFamily	CD molecules\|C-C motif chemokine receptors	CCR2 CCR7	3.74e-04	10	53	2	1091
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	CCR2 CXCR6 ENPP3 CCR7 CDCP1	5.83e-03	394	53	5	471
GeneFamily	Olfactory receptors, family 8	OR8J3 OR8J1	9.08e-03	49	53	2	155
GeneFamily	Olfactory receptors, family 52	OR52B4 OR52E8	9.08e-03	49	53	2	165
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	LRFN2 LRFN5 ADGRF5	1.17e-02	161	53	3	593
GeneFamily	G protein-coupled receptors, Class A orphans	GPR15 GPR87	2.20e-02	78	53	2	262
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Mesenchymal-Cilia-bearing_cell\|10w / Sample Type, Dataset, Time_group, and Cell type.	SLC7A8 CYSLTR1 KCNK13 MARVELD2 F2RL1 GRM8	2.85e-07	199	60	6	2d8ab4aee300c7c4baf662940ce855da2b6d2cae
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADGRF5 GRM7 GRM8 FAM162B OPRM1	3.35e-06	170	60	5	5de2f7d16a05af74ebfb1ca42d0f9c3c3524692d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADGRF5 GRM7 GRM8 FAM162B OPRM1	3.65e-06	173	60	5	9a2d42f8d9cb834856522661d524abb91c4637c5
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADGRF5 GRM7 GRM8 FAM162B OPRM1	3.75e-06	174	60	5	ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCell	CV-Severe-5\|Severe / Virus stimulation, Condition and Cluster	GPR15 CYSLTR1 ARMH1 CCR7 F2RL1	5.91e-06	191	60	5	d04f93fc85c882260ca4d5b4768504fbf8a47984
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 SCGB3A2 MARVELD2 F2RL1 OPRK1	6.06e-06	192	60	5	c15841f35e24d6ef6ce2a9a6dc62e66efdc3d9d5
ToppCell	PCW_05-06-Epithelial-Epithelial_airway\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 SCGB3A2 MARVELD2 GRM8 OPRK1	6.22e-06	193	60	5	af6ec2c2ba92aef3e41531c3c7215b3300437bd9
ToppCell	CD8+_Memory_T_cell-CV-5\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	GPR15 CYSLTR1 ARMH1 CCR7 F2RL1	6.38e-06	194	60	5	5d644fe6da99b023eee100882ee7b71af4f3814a
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 SCGB3A2 MARVELD2 GRM8 OPRK1	6.38e-06	194	60	5	b19e16a76d7342ff9a665d19c9151652916f17d4
ToppCell	Parenchymal-NucSeq-Stromal-Pericyte-Muscle_pericyte_systemic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DPY19L2 LRFN5 GRM8 FAM162B ADCYAP1R1	7.04e-06	198	60	5	882710bd6215e299257dd3df234292db9a2823ba
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb\|Striatum / BrainAtlas - Mouse McCarroll V32	KCNMB2 PROKR1 PROKR2 CCR7	8.31e-06	95	60	4	56350551af6a1ae15652d596002124d8f7885d4f
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Esm1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KCNMB2 PROKR2 OPRK1 OPRM1	2.16e-05	121	60	4	056d0f0f7a4d1b2d38b83647bbe4468b7c959ce6
ToppCell	droplet-Lung-1m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l14\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CCR2 POLR3B DENND1A SP140	2.69e-05	128	60	4	376102331d79010c1b2ce26e6ab0134c7b8a4ec3
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Esm1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KCNMB2 PROKR2 OPRK1 OPRM1	2.95e-05	131	60	4	3cb4b272e28ee9bad6d874f64a7aae18352a6cfb
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Striatum / BrainAtlas - Mouse McCarroll V32	KCNMB2 PROKR1 PROKR2 CCR7	3.13e-05	133	60	4	d5326a6ccada5ae6d3e8f7d4a858c90050e23c5b
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD8-Tnaive/CM_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ARMC12 ARMH1 CCR7 OPRM1	3.93e-05	141	60	4	b2857b73fd754b879b922c7720b5ac3024976822
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Myeloid-macrophage\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCR2 CYSLTR1 KCNK13 PGAP6	5.41e-05	153	60	4	4b999892fb797e9f0d391630094f466463299d57
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Myeloid-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCR2 CYSLTR1 KCNK13 PGAP6	5.41e-05	153	60	4	e426db29e4ba83e7930dc88c74fc975b177c9540
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Myeloid\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCR2 CYSLTR1 KCNK13 PGAP6	5.41e-05	153	60	4	668eacd76aad6054bd7d57e3af0b122c2443465f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCR2 PROKR2 CYSLTR1 SP140	5.41e-05	153	60	4	3724dd498b982be693ddff9cea7671863acf3ff8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCR2 PROKR2 CYSLTR1 SP140	5.41e-05	153	60	4	d810fc5aff28449ce79b4148558b260878a2c696
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KCNMB2 PROKR2 ADCYAP1R1 OPRM1	6.59e-05	161	60	4	dccb61d5e17a8f1c6d1fc146ee389f567659a0f0
ToppCell	facs-Liver-Non-hepatocytes-24m-Lymphocytic-T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR15 CXCR6 CCR7 F2RL1	6.75e-05	162	60	4	15d5d31a75e26bcd41919a00300c68e9f00f0002
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Rgs12_(Fast-spiking_interneuron,_Pvalb+/Rgs12+)\|Striatum / BrainAtlas - Mouse McCarroll V32	KCNMB2 PROKR2 CCR7	6.95e-05	59	60	3	d49a63218a045f3d032d135aee234a3269222abd
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Rgs12_(Fast-spiking_interneuron,_Pvalb+/Rgs12+)-\|Striatum / BrainAtlas - Mouse McCarroll V32	KCNMB2 PROKR2 CCR7	6.95e-05	59	60	3	2d77ae08fa9836bbae158a0e466806a5f9236b5e
ToppCell	LPS-IL1RA-Epithelial_airway-Club_cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SCGB3A2 PTPRR GPR87 CDCP1	7.25e-05	165	60	4	1a114eacaab598f755a173a3fed842ba91f689dd
ToppCell	LPS-IL1RA-Epithelial_airway-Club_cells-Airway\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SCGB3A2 PTPRR GPR87 CDCP1	7.25e-05	165	60	4	9cfd3c1d2c6d714fde83b90465f1f9741b0e50ce
ToppCell	LPS-antiTNF-Epithelial_airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 SCGB3A2 PTPRR GPR87	7.42e-05	166	60	4	eb942ed68677e55c46cb039046f45686d4062d7c
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 SCGB3A2 PTPRR GPR87	7.42e-05	166	60	4	1df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 SCGB3A2 PTPRR GPR87	7.42e-05	166	60	4	9628522e7af8f8edca733588a364ab2454ac5ca5
ToppCell	droplet-Fat-Scat-18m-Myeloid-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A8 CCR2 KCNK13 PGAP6	7.77e-05	168	60	4	749eccebe4ee066f827d2a3980512f195f23ac27
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADGRF5 GRM7 GRM8 OPRM1	7.95e-05	169	60	4	319cba07263bf41fcbcbfecd117f91b729394241
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADGRF5 GRM7 FAM162B OPRM1	8.13e-05	170	60	4	3174ea9cf93892a8b41de10fd4ff6f06bb41502d
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PROKR2 GRM8 FAM162B OPRM1	8.32e-05	171	60	4	9e00c8191ca9d52151a49baf39f8581cb176fb76
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PROKR2 GRM8 FAM162B OPRM1	8.51e-05	172	60	4	92e76cbf4807704790f42cf2507e92f85cd3bc92
ToppCell	droplet-Limb_Muscle-nan-24m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCR2 CXCR6 CCR7 SP140	8.51e-05	172	60	4	770e4c5467ef2eaddf883723fb0aa1226973b000
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCR2 CXCR6 CYSLTR1 CCR7	8.51e-05	172	60	4	adf016e5856bc85e7bed58aee09ade483b9dcb00
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRM7 GRM8 FAM162B OPRM1	8.70e-05	173	60	4	5aa4d45a01d2d09eff8b4deb32bd91ab2471210a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCR2 PROKR2 CYSLTR1 SP140	8.70e-05	173	60	4	62ba49c1c16760a8c6cde0cc44e068f94386946a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADGRF5 GRM8 FAM162B OPRM1	8.70e-05	173	60	4	8ac2e9d39c0f76e674f8bd59d1da246bab4867c8
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADGRF5 GRM7 FAM162B OPRM1	8.90e-05	174	60	4	b3cd22e717d178269e6d5bd5ed7b2d945cd8ea25
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-5\|TCGA-Pancreas / Sample_Type by Project: Shred V9	PTGES GPR87 TTC9 CDCP1	8.90e-05	174	60	4	73e1ad4007d94fca25ed7c6fbe5d205d4e1b8a3b
ToppCell	10x3'2.3-week_17-19-Lymphocytic_T-T_NK-Treg\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CCR2 ANO9 CXCR6 CCR7	8.90e-05	174	60	4	7ca39c9ecd609e5ade30dac1a948a4a4fff1b3b2
ToppCell	droplet-Spleen-SPLEEN-30m-Lymphocytic-mature_NK_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCR2 CXCR6 NBEAL2 F2RL1	9.51e-05	177	60	4	52402ff6299210c46fd9dee3cef203c0eda7a98a
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-mature_NK_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCR2 CXCR6 NBEAL2 F2RL1	9.51e-05	177	60	4	6561794ae3b14b5279b249eb5e93b80ef15ed82c
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNMB2 ARFGEF3 MARVELD2 OPRK1	9.51e-05	177	60	4	c80893e5cf5688ee9f5afc8f11b3890f296c9e1f
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-ILC2\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCR2 CXCR6 CYSLTR1 TTC9	9.72e-05	178	60	4	5101a45595cd8d702f911afadf1eb0ee10bdcefc
ToppCell	15-Trachea-Epithelial-Goblet-like_secretory\|Trachea / Age, Tissue, Lineage and Cell class	SLC7A8 ARFGEF3 SCGB3A2 ADGRF5	9.72e-05	178	60	4	f0557920b9b3e7c4f39938d1b524aa58711af4d2
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CXCR6 CCR7 GRM7 OPRK1	9.93e-05	179	60	4	dd3cf8fd10dc257d933a7f45860dc2e244c158b7
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Lymphocytic-T_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCR2 GPR15 CXCR6 LRFN5	1.01e-04	180	60	4	5fdd10ffdf49f0e818f865ca095a3882b35c640e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_RORB_CARTPT\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADGRF5 GRM8 FAM162B OPRM1	1.01e-04	180	60	4	5e78b29fa1cbdcf502fee3577e5b45766b90d1dc
ToppCell	367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|367C / Donor, Lineage, Cell class and subclass (all cells)	ADGRF5 MARVELD2 OR2B6 GRM8	1.01e-04	180	60	4	162cec1734e560c068cd61717e40e18dcf92308c
ToppCell	10x5'v1-week_14-16-Lymphocytic_NK-T_NK-ILC_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	GPR15 CXCR6 GRM7 OPRK1	1.01e-04	180	60	4	a999a6d219a8e58a8b63802ddf8c95ffaab9cfa0
ToppCell	367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	ADGRF5 MARVELD2 OR2B6 GRM8	1.01e-04	180	60	4	33c86c22ba877358cd8c1e39b5c0b3dc3a45b7dd
ToppCell	5'-GW_trimst-1-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MARVELD2 CDCP1 F2RL1 FAM162B	1.04e-04	181	60	4	c1203787cc3f968147fabdd3c646a04be96f6552
ToppCell	5'-GW_trimst-1-SmallIntestine-Epithelial-mature_enterocytic\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MARVELD2 CDCP1 F2RL1 FAM162B	1.04e-04	181	60	4	f7258af89f4cc89446ff6754bdaa769320af95d6
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 MARVELD2 GRM8 OPRK1	1.08e-04	183	60	4	c5b10571599dc26476170b54b53f09c23e6b3117
ToppCell	remission-CD8+_T_naive\|remission / disease stage, cell group and cell class	ANO9 ARMH1 CCR7 OPRM1	1.10e-04	184	60	4	fe20fa4457d4a4a75689978275b0afb5f6243faf
ToppCell	facs-Trachea-3m-Epithelial-airway_epithelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SCGB3A2 GPR87 TTC9 CDCP1	1.15e-04	186	60	4	37b93ebd64ebbd08193a746e5bc9b350c2570733
ToppCell	Substantia_nigra-Macroglia-OLIGODENDROCYTE-O2-Tfr\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GPR15 ENPP3 KCNK13	1.16e-04	70	60	3	125f8e8fcd14420dff5b18f2270516d5baafd38e
ToppCell	Control-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	RIN2 ADGRF5 MARVELD2 GRM8	1.20e-04	188	60	4	88b3415e33db81726dd29c1f50c886e057af50a0
ToppCell	E12.5-Epithelial-alveolar_epithelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TTC9 MARVELD2 CDCP1 F2RL1	1.20e-04	188	60	4	c19c89756f2f999e0814f08a89818ef156f6fc69
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARFGEF3 PROKR1 PTPRR OPRM1	1.22e-04	189	60	4	cceca3d14dd559bbb2cb4b81ea12c2b62d18ee49
ToppCell	COPD-Epithelial-Club\|COPD / Disease state, Lineage and Cell class	ARFGEF3 NCKAP1 SCGB3A2 ADGRF5	1.27e-04	191	60	4	c909cf5fa0e6519aa93a47d2c3fcd2ae2163cd8d
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 SCGB3A2 GRM8 OPRK1	1.27e-04	191	60	4	60ff989fe99d243a3d52955223680cdd1f1917a4
ToppCell	wk_08-11-Epithelial-PNS-SST+_neuron\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	LRFN2 PTPRR GRM8 OPRM1	1.27e-04	191	60	4	df2bef74a54f4c23c99bd3b93225fd36bcd90723
ToppCell	IPF-Epithelial-Club\|World / Disease state, Lineage and Cell class	ARFGEF3 NCKAP1 SCGB3A2 ADGRF5	1.27e-04	191	60	4	3c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCell	PCW_13-14-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 ANO9 SCGB3A2 MARVELD2	1.27e-04	191	60	4	63aa671837b79d2feb7ed1e67712cc01caf72bef
ToppCell	CV-Mild-5\|Mild / Virus stimulation, Condition and Cluster	GPR15 CYSLTR1 ARMH1 CCR7	1.33e-04	193	60	4	2053f0f8083b3174e1b6f76d2d7089f59982565d
ToppCell	CV-Severe-5\|CV / Virus stimulation, Condition and Cluster	GPR15 ARMH1 CCR7 F2RL1	1.33e-04	193	60	4	d87fcd4553b6198c3128685b73ffd1b1ae88fbb5
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-airway_progenitor_early\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ANO9 SCGB3A2 GRM8 OPRK1	1.33e-04	193	60	4	de569c6e507856fd3ac2311f246cb597074ed30c
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B-B_plasma\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CCR2 GPR15 CCR7 SP140	1.33e-04	193	60	4	282b47dae6043eabb1e13d41d91c07b5ec21cd65
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-C\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ANO9 GPR15 CXCR6 SP140	1.33e-04	193	60	4	bbe642f8b66ba9d028709deaf847f2f7e73be04f
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 SCGB3A2 MARVELD2 GRM8	1.35e-04	194	60	4	c5ef4ff73b4e51530656002e3a2fb7264cdf533d
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-B_cell-B_cell-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DPY19L2 CYSLTR1 CCR7 SP140	1.35e-04	194	60	4	9a99abc65e7509e7ae8fb392f5ee4b2a83128072
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 SCGB3A2 GRM8 OPRK1	1.35e-04	194	60	4	6b286992d4bb56013c0ea5a7601d3476d806175a
ToppCell	PCW_05-06-Epithelial\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 SCGB3A2 MARVELD2 GRM8	1.35e-04	194	60	4	47a1369c22fcbfe00b08376eb610a61c355548db
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ARFGEF3 SCGB3A2 GRM8 OPRK1	1.35e-04	194	60	4	f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCell	Control-Multiplet\|Control / Disease state, Lineage and Cell class	ARFGEF3 NCKAP1 SCGB3A2 ADGRF5	1.38e-04	195	60	4	618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCell	CV-Moderate-5\|CV / Virus stimulation, Condition and Cluster	GPR15 CYSLTR1 ARMH1 CCR7	1.38e-04	195	60	4	7a0bb304c659dd108b75d0c5d19eca5e63cf856d
ToppCell	Control-Multiplet-Multiplet\|Control / Disease state, Lineage and Cell class	ARFGEF3 NCKAP1 SCGB3A2 ADGRF5	1.38e-04	195	60	4	06ac685855e14e4dd2cbe6d0e73f894f2eeff91f
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	ARFGEF3 NCKAP1 SCGB3A2 ADGRF5	1.41e-04	196	60	4	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Club\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ARFGEF3 SCGB3A2 ADGRF5 OPRK1	1.41e-04	196	60	4	d5f9168001e60bafec17fe6c702e68f5528edc20
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	ARFGEF3 NCKAP1 SCGB3A2 ADGRF5	1.41e-04	196	60	4	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-airway_progenitor_early\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ANO9 NBEAL2 GRM8 OPRK1	1.44e-04	197	60	4	4ae08ccb6f1da626c4f0fb0140a2811cb6e31ba1
ToppCell	LPS_only-Epithelial_airway-airway_epithelial-Airway-Club\|LPS_only / Treatment groups by lineage, cell group, cell type	ARFGEF3 SCGB3A2 PTPRR GPR87	1.49e-04	199	60	4	165ac94b2d56072ad43358b5127d77555221e2d8
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-AT1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OR5P2 SCGB3A2 NBEAL2 ADGRF5	1.49e-04	199	60	4	f8846446ebbc4948cdc69640782db1358bbdc486
ToppCell	Parenchyma_COVID-19-Epithelial-TX-AT1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	OR5P2 SCGB3A2 NBEAL2 ADGRF5	1.49e-04	199	60	4	fe9f5bc317be0c35bd96311bf0b3c7b91d98acc5
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CCR2 GPR15 CYSLTR1 SP140	1.49e-04	199	60	4	58242d78517c05fa367a7c6edac57ef79107453c
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-AT1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	OR5P2 SCGB3A2 NBEAL2 ADGRF5	1.49e-04	199	60	4	3e35ee426ef06f9af568c37349b62dd1ee9b97ea
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-T-T_CD4\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GPR15 CXCR6 CCR7 SP140	1.49e-04	199	60	4	e655cb92fe674b07096bb697d6befe0314ccbc5f
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-FILIP1L\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ADGRF5 GRM7 GRM8 OPRM1	1.52e-04	200	60	4	f6af5ef02625aaae21e885e1ebd195e34731e53a
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-FILIP1L-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ADGRF5 GRM7 GRM8 OPRM1	1.52e-04	200	60	4	53f61e28c3ad6399f63c54e06120ecb5ebbf90d9
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-FILIP1L--L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ADGRF5 GRM7 GRM8 OPRM1	1.52e-04	200	60	4	c1f243ae929f7791e040437470033abf749b44cc
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-squamous_epithelial_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	NCKAP1 GPR87 TTC9 CDCP1	1.52e-04	200	60	4	1c02a7f4047d1d2208cc522c6bb4a4989d7845bb
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-squamous_epithelial_cell-Epi-Squamous\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	NCKAP1 GPR87 TTC9 CDCP1	1.52e-04	200	60	4	03051d2190244208905e1611019d4b8fd200bae0
ToppCell	Biopsy_Other_PF-Epithelial-SCGB3A2+\|Biopsy_Other_PF / Sample group, Lineage and Cell type	ARFGEF3 SCGB3A2 GPR87 ADGRF5	1.52e-04	200	60	4	631550dc34bcb605ab726645f4024d7828bb7975
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PROKR1 ENPP3 CCR7	2.36e-04	89	60	3	b66575739cb5b89234bbb8a3ea2f244e0bd19cff
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PROKR1 ENPP3 CCR7	2.36e-04	89	60	3	26f01e8530b313dd5e95ea6c20fa362e34b9ed24
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Mgp_(Mgp)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ENPP3 PTGES ABCB6	3.73e-04	104	60	3	11d91471b6c4fa6b00a91d9fd4db72ee60d1f801
Computational	GPCR signaling pathways (immune and neuro).	CCR2 CXCR6 GRM8 ADCYAP1R1 OPRK1	4.44e-06	90	30	5	MODULE_375
Computational	Genes in the cancer module 289.	CCR2 CXCR6 GRM8 ADCYAP1R1 OPRK1	2.13e-05	124	30	5	MODULE_289
Computational	Genes in the cancer module 134.	CCR2 CXCR6 OPRK1	7.57e-05	30	30	3	MODULE_134
Computational	Genes in the cancer module 288.	CCR2 CXCR6 OPRK1	1.43e-04	37	30	3	MODULE_288
Computational	Genes in the cancer module 146.	CCR2 CXCR6 ADCYAP1R1 OPRK1	1.73e-04	102	30	4	MODULE_146
Computational	Genes in the cancer module 27.	CCR2 CXCR6 PTPRR ADCYAP1R1 OPRK1 OPRM1	3.77e-04	355	30	6	MODULE_27
Computational	Neighborhood of MAP2K7	GPR15 PTPRR OR2B6 F2RL1	1.51e-03	181	30	4	MORF_MAP2K7
Computational	Neighborhood of CTSB	GPR15 PTPRR OR2B6 F2RL1	1.71e-03	187	30	4	MORF_CTSB
Drug	3-dadh-ol	OPRK1 OPRM1	6.60e-06	2	59	2	CID000128663
Drug	Dezocine	OPRK1 OPRM1	6.60e-06	2	59	2	DB01209
Drug	GUM1 compound	OPRK1 OPRM1	6.60e-06	2	59	2	ctd:C000611307
Drug	P 7521	OPRK1 OPRM1	6.60e-06	2	59	2	CID000146384
Drug	N-propargyl	OPRK1 OPRM1	6.60e-06	2	59	2	ctd:C440369
Drug	N-(3-iodoprop-(2)-enyl)	OPRK1 OPRM1	6.60e-06	2	59	2	ctd:C440388
Drug	methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate	OPRK1 OPRM1	6.60e-06	2	59	2	ctd:C533093
Drug	Cyclazocine	OPRK1 OPRM1	6.60e-06	2	59	2	ctd:D003496
Drug	paynantheine	OPRK1 OPRM1	6.60e-06	2	59	2	ctd:C580857
Drug	dihydroheroin	OPRK1 OPRM1	6.60e-06	2	59	2	CID005359460
Drug	AC1L9NAZ	PSEN1 SCGB3A2 GRM8 ADCYAP1R1 OPRK1 OPRM1	1.23e-05	198	59	6	CID000449606
Drug	Oxaprozin [21256-18-8]; Up 200; 13.6uM; MCF7; HT_HG-U133A	KCNMB2 CXCR6 CDCP1 GRM7 GRM8 OPRM1	1.23e-05	198	59	6	4352_UP
Drug	Pentazocine	OPRK1 OPRM1	1.98e-05	3	59	2	ctd:D010423
Drug	cyclorphan	OPRK1 OPRM1	1.98e-05	3	59	2	ctd:C084603
Drug	TRK 820	OPRK1 OPRM1	1.98e-05	3	59	2	ctd:C111212
Drug	Oxycodone	OPRK1 OPRM1	1.98e-05	3	59	2	DB00497
Drug	Hydromorphone	OPRK1 OPRM1	1.98e-05	3	59	2	DB00327
Drug	Codeine	OPRK1 OPRM1	1.98e-05	3	59	2	DB00318
Drug	Lactoferroxin C	OPRK1 OPRM1	1.98e-05	3	59	2	CID000192714
Drug	Lactoferroxin B	OPRK1 OPRM1	1.98e-05	3	59	2	CID000192715
Drug	Lactoferroxin A	OPRK1 OPRM1	1.98e-05	3	59	2	CID000192716
Drug	Carfentanil	OPRK1 OPRM1	1.98e-05	3	59	2	DB01535
Drug	Morphine	OPRK1 OPRM1	1.98e-05	3	59	2	DB00295
Drug	Hydrocodone	OPRK1 OPRM1	1.98e-05	3	59	2	ctd:D006853
Drug	3-Methylfentanyl	OPRK1 OPRM1	1.98e-05	3	59	2	DB01571
Drug	Alvimopan	OPRK1 OPRM1	1.98e-05	3	59	2	DB06274
Drug	dextrallorphan	OPRK1 OPRM1	1.98e-05	3	59	2	ctd:C044130
Drug	Heroin	OPRK1 OPRM1	1.98e-05	3	59	2	DB01452
Drug	3-Methylthiofentanyl	OPRK1 OPRM1	1.98e-05	3	59	2	DB01439
Drug	14-phenylpropoxymetopon	OPRK1 OPRM1	1.98e-05	3	59	2	ctd:C478565
Drug	morphine-7,8-oxide	OPRK1 OPRM1	1.98e-05	3	59	2	CID005491901
Drug	Levorphanol	OPRK1 OPRM1	1.98e-05	3	59	2	ctd:D007981
Drug	Levallorphan	OPRK1 OPRM1	1.98e-05	3	59	2	ctd:D007977
Drug	Buprenorphine	OPRK1 OPRM1	1.98e-05	3	59	2	DB00921
Drug	Levorphanol	OPRK1 OPRM1	1.98e-05	3	59	2	DB00854
Drug	Remifentanil	OPRK1 OPRM1	1.98e-05	3	59	2	DB00899
Drug	Nalbuphine	OPRK1 OPRM1	1.98e-05	3	59	2	DB00844
Drug	Fentanyl	OPRK1 OPRM1	1.98e-05	3	59	2	DB00813
Drug	Sufentanil	OPRK1 OPRM1	1.98e-05	3	59	2	DB00708
Drug	Propoxyphene	OPRK1 OPRM1	1.98e-05	3	59	2	DB00647
Drug	Butorphanol	OPRK1 OPRM1	1.98e-05	3	59	2	DB00611
Drug	bromadoline	OPRK1 OPRM1	1.98e-05	3	59	2	CID000054753
Drug	Butorphanol	OPRK1 OPRM1	1.98e-05	3	59	2	ctd:D002077
Drug	Pentazocine	OPRK1 OPRM1	1.98e-05	3	59	2	DB00652
Drug	Nalbuphine	OPRK1 OPRM1	3.95e-05	4	59	2	ctd:D009266
Drug	Dynorphins	OPRK1 OPRM1	3.95e-05	4	59	2	ctd:D004399
Drug	AC1L5BQM	OPRK1 OPRM1	3.95e-05	4	59	2	CID000174892
Drug	Diprenorphine	OPRK1 OPRM1	3.95e-05	4	59	2	DB01548
Drug	3B-b	OPRK1 OPRM1	3.95e-05	4	59	2	CID000533975
Drug	diphenoxylate	OPRK1 OPRM1	3.95e-05	4	59	2	CID000013505
Drug	Meperidine	OPRK1 OPRM1	3.95e-05	4	59	2	ctd:D008614
Drug	Methadyl Acetate	OPRK1 OPRM1	3.95e-05	4	59	2	ctd:D008692
Drug	7-hydroxymitragynine	OPRK1 OPRM1	3.95e-05	4	59	2	ctd:C482678
Drug	NSC1953	OPRK1 OPRM1	3.95e-05	4	59	2	CID000102946
Drug	Naltrexone	OPRK1 OPRM1	3.95e-05	4	59	2	DB00704
Drug	Dihydromorphine	OPRK1 OPRM1	6.57e-05	5	59	2	DB01565
Drug	Naloxone	OPRK1 OPRM1	6.57e-05	5	59	2	DB01183
Drug	nalorphine-epoxide	OPRK1 OPRM1	6.57e-05	5	59	2	CID003086440
Drug	oxymorphamine	OPRK1 OPRM1	6.57e-05	5	59	2	CID000134844
Drug	nalmefene	OPRK1 OPRM1	6.57e-05	5	59	2	ctd:C038981
Drug	Sc 39566	OPRK1 OPRM1	6.57e-05	5	59	2	CID000130018
Drug	XeC compound	PSEN1 F2RL1 GRM8 ADCYAP1R1	6.72e-05	84	59	4	CID000005701
Drug	Zymosan	CCR2 CYSLTR1 PTGES OPRK1 OPRM1	8.36e-05	172	59	5	ctd:D015054
Drug	Pilocarpine	CCR2 PTGES CCR7 GRM8 OPRK1 OPRM1	9.42e-05	285	59	6	ctd:D010862
Drug	Etorphine	OPRK1 OPRM1	9.84e-05	6	59	2	DB01497
Drug	AC1L2OET	OPRK1 OPRM1	9.84e-05	6	59	2	CID000125331
Drug	NSC612111	OPRK1 OPRM1	9.84e-05	6	59	2	CID000163346
Drug	Loperamide	OPRK1 OPRM1	9.84e-05	6	59	2	DB00836
Drug	RX8008M	OPRK1 OPRM1	9.84e-05	6	59	2	CID000162443
Drug	phenylquinone	PTGES OPRK1 OPRM1	1.11e-04	36	59	3	CID000009688
Drug	tetradotoxin	KCNMB2 GRM7 F2RL1 GRM8 ADCYAP1R1 OPRK1 OPRM1	1.16e-04	428	59	7	CID000020382
Drug	tert-butylamine	CCR7 OPRK1 OPRM1	1.21e-04	37	59	3	CID000006385
Drug	AC1L1DXE	PROKR1 PSEN1 PROKR2 F2RL1 OPRK1 OPRM1	1.23e-04	299	59	6	CID000002548
Drug	baclofen	KCNK13 GRM7 GRM8 OPRK1 OPRM1	1.37e-04	191	59	5	CID000002284
Drug	Pcl-dpdpe	OPRK1 OPRM1	1.37e-04	7	59	2	CID000159564
Drug	Tyr-ala-phe-gly	OPRK1 OPRM1	1.37e-04	7	59	2	CID005487532
Drug	Dextropropoxyphene	OPRK1 OPRM1	1.37e-04	7	59	2	ctd:D011431
Drug	aminocyclohexanecarboxylic acid	OPRK1 OPRM1	1.37e-04	7	59	2	CID000171560
Drug	Enkephalin, D-Penicillamine (2,5)-	OPRK1 OPRM1	1.37e-04	7	59	2	ctd:D020881
Drug	MET-CAMO	OPRK1 OPRM1	1.37e-04	7	59	2	CID006450159
Drug	phenylmorphan	OPRK1 OPRM1	1.37e-04	7	59	2	CID000146306
Drug	AC1L9PCU	OPRK1 OPRM1	1.37e-04	7	59	2	CID000451042
Drug	N-cyclopropylmethylnorazidomorphine	OPRK1 OPRM1	1.37e-04	7	59	2	CID005489191
Drug	beta-naltrexamine	OPRK1 OPRM1	1.37e-04	7	59	2	CID005486948
Drug	Dextrorphan	OPRK1 OPRM1	1.37e-04	7	59	2	ctd:D003917
Drug	NDTMB	OPRK1 OPRM1	1.37e-04	7	59	2	CID000134748
Drug	2-mercaptoacetate	OPRK1 OPRM1	1.37e-04	7	59	2	ctd:C017487
Drug	Diltiazem hydrochloride [33286-22-5]; Up 200; 8.8uM; PC3; HT_HG-U133A	CYSLTR1 PTGES CCR7 GRM7 GRM8	1.47e-04	194	59	5	6710_UP
Drug	Hymecromone [90-33-5]; Up 200; 22.8uM; PC3; HT_HG-U133A	PTPRR PEX3 ADGRF5 TTC9 GRM8	1.54e-04	196	59	5	4623_UP
Drug	Meclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; MCF7; HT_HG-U133A	GPR15 PEX3 CYP20A1 OR2B6 GRM7	1.54e-04	196	59	5	3277_UP
Drug	ICI 204448	OPRK1 OPRM1	1.83e-04	8	59	2	CID000003683
Drug	cis-MCG-I	GRM7 GRM8	1.83e-04	8	59	2	CID003035584
Drug	U 69593	OPRK1 OPRM1	1.83e-04	8	59	2	ctd:C045444
Drug	metazocine	OPRK1 OPRM1	1.83e-04	8	59	2	CID000062518
Drug	AC1L1B1Q	OPRK1 OPRM1	1.83e-04	8	59	2	CID000001246
Drug	DIPPA	OPRK1 OPRM1	1.83e-04	8	59	2	CID000127914
Drug	14-methoxymetopon	OPRK1 OPRM1	1.83e-04	8	59	2	CID005486940
Drug	KT-89	OPRK1 OPRM1	1.83e-04	8	59	2	CID005748450
Drug	binaltorphimine	OPRK1 OPRM1	1.83e-04	8	59	2	CID005484197
Drug	N-methyl nalorphine	OPRK1 OPRM1	1.83e-04	8	59	2	CID005748235
Disease	Pruritus	F2RL1 OPRM1	9.83e-05	8	56	2	C0033774
Disease	asthma (is_implicated_in)	CCR2 SCGB3A2 CYSLTR1 F2RL1	2.28e-04	157	56	4	DOID:2841 (is_implicated_in)
Disease	response to anticonvulsant	KCNMB2 RIN2 SP140	5.73e-04	85	56	3	GO_0036277
Disease	Attention Deficit Disorder	GRM7 GRM8	7.98e-04	22	56	2	C0041671
Disease	Minimal Brain Dysfunction	GRM7 GRM8	7.98e-04	22	56	2	C1321905
Disease	Anhedonia	CCR7 OPRK1	9.51e-04	24	56	2	C0178417
Disease	Attention deficit hyperactivity disorder	GRM7 GRM8	9.51e-04	24	56	2	C1263846
Disease	osteonecrosis	PTPRR LRFN5	1.03e-03	25	56	2	EFO_0004259
Disease	plasma clusterin measurement	KCNMB2 GRM7	1.03e-03	25	56	2	EFO_0007656
Disease	Drug habituation	CDCP1 GRM7 OPRM1	1.38e-03	115	56	3	C0013170
Disease	Substance-Related Disorders	CDCP1 GRM7 OPRM1	1.38e-03	115	56	3	C0236969
Disease	Drug abuse	CDCP1 GRM7 OPRM1	1.38e-03	115	56	3	C0013146
Disease	Drug Use Disorders	CDCP1 GRM7 OPRM1	1.38e-03	115	56	3	C0013222
Disease	Drug Dependence	CDCP1 GRM7 OPRM1	1.38e-03	115	56	3	C1510472
Disease	Substance Dependence	CDCP1 GRM7 OPRM1	1.38e-03	115	56	3	C0038580
Disease	Substance Use Disorders	CDCP1 GRM7 OPRM1	1.38e-03	115	56	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	CDCP1 GRM7 OPRM1	1.38e-03	115	56	3	C0029231
Disease	Prescription Drug Abuse	CDCP1 GRM7 OPRM1	1.38e-03	115	56	3	C4316881
Disease	Mental Depression	PSEN1 GRM7 OPRK1 OPRM1	1.39e-03	254	56	4	C0011570
Disease	colorectal cancer, overall survival	LRFN2 LRFN5	1.39e-03	29	56	2	EFO_0000638, MONDO_0005575
Disease	Substance abuse problem	CDCP1 GRM7 OPRM1	1.41e-03	116	56	3	C0740858
Disease	rhinitis (is_implicated_in)	CCR2 CYSLTR1	1.49e-03	30	56	2	DOID:4483 (is_implicated_in)
Disease	Alcoholic Intoxication, Chronic	GRM7 GRM8 OPRK1 OPRM1	1.69e-03	268	56	4	C0001973
Disease	Depressive disorder	PSEN1 GRM7 OPRK1 OPRM1	2.22e-03	289	56	4	C0011581
Disease	body weight	LRFN2 DPY19L2 PTPRR LRFN5 RIN2 GRM7 DENND1A OPRM1	2.49e-03	1261	56	8	EFO_0004338
Disease	personality trait	GRM7 DENND1A	2.51e-03	39	56	2	EFO_0004365
Disease	rhinitis (is_marker_for)	SCGB3A2 CYSLTR1	3.47e-03	46	56	2	DOID:4483 (is_marker_for)
Disease	congenital left-sided heart lesions	KCNMB2 ADCYAP1R1	3.77e-03	48	56	2	EFO_0005938

Protein segments in the cluster

Peptide	Gene	Start	Entry
TMIVCYSVIIKTLLH	CXCR6	206	O00574
CYIVISKRHITMLSI	CDCP1	56	Q9H5V8
LRITYMTDSCLEKLL	ARMH1	66	Q6PIY5
VLLLTCMSVDRYLAI	GPR15	121	P49685
LLAMSFCYLVIIRTL	CCR7	236	P32248
IVFLCMSLYLTLTIV	ABCB6	416	Q9NP58
SYLRSTVILVLTLLM	ANO9	326	A1A5B4
KSMILHSITRCVYLL	ARMC12	86	Q5T9G4
ELLTLVSQKMCVVVY	SLC7A8	481	Q9UHI5
VLVFIIILMIRYKVC	LRFN5	541	Q96NI6
TVCYGLMILRLKSVR	OPRM1	251	P35372
MLVNLCSIRKVISYR	OR2B6	81	P58173
MVKLTQYLSLLCERI	KCNMB2	216	Q9Y691
ALIKKICVTVSLRSY	OR52B4	141	Q8NGK2
TVAVYSTCMLVVLLR	PEX3	116	P56589
SLLMVVLVLSYKSIC	IFNA7	6	P01567
LERLITIIAYIMKSC	KCNK13	146	Q9HB14
TILCMARLKTVLKYV	PGAP6	621	Q9HCN3
VSTSRILVAVVKMCY	PSMD12	61	O00232
RYTKTLLLPVVMVIT	DPY19L2	491	Q6NUT2
LYMVVVSRRLCLLLV	OR8J3	131	Q8NGG0
SILLMVTCTVYAIKT	GRM8	756	O00222
RMYSITFTKVLSVCV	GPR87	151	Q9BY21
LIITYTTLMILLSRI	NCKAP1	136	Q9Y2A7
VTLTTAMVILCRFRK	ADCYAP1R1	166	P41586
SIFVIIVTCLMILYR	PTPRR	236	Q15256
AVCYIYILITILKMR	OR5P2	211	Q8WZ92
IKLIVTVLAMYLICF	F2RL1	286	P55085
LYMVVVSRRLCLLLV	OR8J1	131	Q8NGP2
CLRLITTLSDKYMLV	G2E3	526	Q7L622
YKIACIVLLALLVIM	ENPP3	21	O14638
LQVEVMKVLLCITYT	ARFGEF3	111	Q5TH69
LIMVICYSGILKTLL	CCR2	216	P41597
TMIVYLISALVCLKL	MARVELD2	351	Q8N4S9
MLYERRILIICSKLS	DENND1A	191	Q8TEH3
LMVTCTVYAIKTRGV	GRM7	766	Q14831
YMVTTVLLSVLVKRL	CYP20A1	416	Q6UW02
LMLIITLVSVYCTRK	MEP1B	666	Q16820
RVKACYIMIGLTIIA	FAM162B	106	Q5T6X4
MLKKLLISYISIICV	LRRC8D	361	Q7L1W4
VSYICILMTILKIQT	OR5G3	216	P0C626
IIIVCYTLMILRLKS	OPRK1	241	P41145
LRYTMILTSKIISLI	OR52E8	136	Q6IFG1
CLKVIVSLTVYTLFM	RNF139	431	Q8WU17
MKLVTIFLLVTISLC	SCGB3A2	1	Q96PL1
SVIVVMTILLVVLYK	PSEN1	141	P49768
IMIILTSYLLILTTI	OR5L1	211	Q8NGL2
TLVVAVCTRKEYLTM	NBEAL2	651	Q6ZNJ1
FLLCSTLLVIKMYVV	PTGES	16	O14684
IMIILTSYLLILTTI	OR5L2	211	Q8NGL0
RTTLCLMFIVIYSSK	ADGRF5	6	Q8IZF2
IVCYTMIILTLLKKS	CYSLTR1	206	Q9Y271
KTVLVLMCILTAYVL	PROKR1	281	Q8TCW9
VMLLLRVCKLIYTVM	RIN2	671	Q8WYP3
RKTVLVLMCILTAYV	PROKR2	271	Q8NFJ6
KCIYTAVMVRRVILA	POLR3B	331	Q9NW08
SLALCVRILTTYLLM	SLC9B1	406	Q4ZJI4
VTRVMYCVLSELEKT	SP140	91	Q13342
IRYIQLTEMKLSRCS	TTC9	201	Q92623
LLVFIVILMVRYKVC	LRFN2	546	Q9ULH4