Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	CYBB NOX3 NOX1	8.96e-07	12	33	3	GO:0016175
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	CYBB NOX3 NOX1	4.60e-06	20	33	3	GO:0050664
GeneOntologyMolecularFunction	superoxide-generating NADPH oxidase activity	NOX3 NOX1	1.59e-05	4	33	2	GO:0106292
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H	CYBB NOX3 NOX1	5.13e-04	95	33	3	GO:0016651
GeneOntologyMolecularFunction	glycosyltransferase activity	ST6GALNAC1 PIGQ FUT4 PIGM	1.25e-03	288	33	4	GO:0016757
GeneOntologyBiologicalProcess	glycolipid biosynthetic process	ST6GALNAC1 PIGQ FUT4 PIGM	8.28e-06	81	33	4	GO:0009247
GeneOntologyBiologicalProcess	glycolipid metabolic process	ST6GALNAC1 PIGQ FUT4 PIGM	3.79e-05	119	33	4	GO:0006664
GeneOntologyBiologicalProcess	liposaccharide metabolic process	ST6GALNAC1 PIGQ FUT4 PIGM	3.91e-05	120	33	4	GO:1903509
GeneOntologyBiologicalProcess	superoxide anion generation	CYBB NOX3 NOX1	6.95e-05	50	33	3	GO:0042554
GeneOntologyBiologicalProcess	cellular component assembly involved in morphogenesis	ADPRHL1 NEB PGM5 POC1B	1.09e-04	156	33	4	GO:0010927
GeneOntologyBiologicalProcess	cellular anatomical entity morphogenesis	ADPRHL1 NEB PGM5 POC1B	1.09e-04	156	33	4	GO:0032989
GeneOntologyBiologicalProcess	membrane lipid biosynthetic process	ST6GALNAC1 PIGQ FUT4 PIGM	1.11e-04	157	33	4	GO:0046467
GeneOntologyBiologicalProcess	self proteolysis	CASP12 DHH	2.57e-04	15	33	2	GO:0097264
GeneOntologyBiologicalProcess	superoxide metabolic process	CYBB NOX3 NOX1	3.14e-04	83	33	3	GO:0006801
GeneOntologyBiologicalProcess	myofibril assembly	ADPRHL1 NEB PGM5	3.49e-04	86	33	3	GO:0030239
GeneOntologyBiologicalProcess	striated muscle cell development	ADPRHL1 NEB PGM5	3.86e-04	89	33	3	GO:0055002
GeneOntologyBiologicalProcess	membrane lipid metabolic process	ST6GALNAC1 PIGQ FUT4 PIGM	4.70e-04	229	33	4	GO:0006643
GeneOntologyBiologicalProcess	cardiac myofibril assembly	ADPRHL1 NEB	5.11e-04	21	33	2	GO:0055003
GeneOntologyCellularComponent	NADPH oxidase complex	CYBB NOX3 NOX1	2.88e-06	18	33	3	GO:0043020
Domain	Cyt_b245_heavy_chain	CYBB NOX3 NOX1	2.01e-08	4	33	3	IPR000778
Domain	NAD_binding_6	CYBB NOX3 NOX1	1.75e-07	7	33	3	PF08030
Domain	FAD-bd_8	CYBB NOX3 NOX1	1.75e-07	7	33	3	IPR013112
Domain	Fe_red_NAD-bd_6	CYBB NOX3 NOX1	1.75e-07	7	33	3	IPR013121
Domain	FAD_binding_8	CYBB NOX3 NOX1	1.75e-07	7	33	3	PF08022
Domain	Fe3_Rdtase_TM_dom	CYBB NOX3 NOX1	1.09e-06	12	33	3	IPR013130
Domain	Ferric_reduct	CYBB NOX3 NOX1	1.09e-06	12	33	3	PF01794
Domain	Fd_Rdtase_FAD-bd	CYBB NOX3 NOX1	4.78e-06	19	33	3	IPR017927
Domain	FAD_FR	CYBB NOX3 NOX1	4.78e-06	19	33	3	PS51384
Domain	Riboflavin_synthase-like_b-brl	CYBB NOX3 NOX1	4.78e-06	19	33	3	IPR017938
Domain	PXA	SNX14 SNX13	1.81e-05	4	33	2	SM00313
Domain	PXA	SNX14 SNX13	1.81e-05	4	33	2	PS51207
Domain	Phox_assoc	SNX14 SNX13	1.81e-05	4	33	2	IPR003114
Domain	Sorting_nexin_C	SNX14 SNX13	1.81e-05	4	33	2	IPR013937
Domain	PXA	SNX14 SNX13	1.81e-05	4	33	2	PF02194
Domain	Nexin_C	SNX14 SNX13	1.81e-05	4	33	2	PF08628
Domain	RGS	SNX14 SNX13	1.74e-03	35	33	2	PF00615
Domain	RGS	SNX14 SNX13	1.74e-03	35	33	2	SM00315
Domain	RGS	SNX14 SNX13	1.84e-03	36	33	2	PS50132
Domain	RGS	SNX14 SNX13	2.15e-03	39	33	2	IPR016137
Domain	PX	SNX14 SNX13	2.73e-03	44	33	2	SM00312
Domain	PX	SNX14 SNX13	3.38e-03	49	33	2	PF00787
Domain	PX	SNX14 SNX13	3.52e-03	50	33	2	PS50195
Domain	-	SNX14 SNX13	3.66e-03	51	33	2	3.30.1520.10
Domain	Phox	SNX14 SNX13	3.80e-03	52	33	2	IPR001683
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES	CYBB NOX3 NOX1	1.10e-05	24	26	3	M27553
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES	CYBB NOX3 NOX1	1.25e-05	25	26	3	MM15269
Pathway	WP_OXIDATIVE_STRESS_RESPONSE	CYBB NOX3 NOX1	2.93e-05	33	26	3	M39645
Pubmed	NADPH oxidase subunit, gp91(phox) homologue, preferentially expressed in human colon epithelial cells.	CYBB NOX3 NOX1	7.78e-10	3	33	3	10974555
Pubmed	Constitutive NADPH oxidase 4 activity resides in the composition of the B-loop and the penultimate C terminus.	CYBB NOX3 NOX1	3.11e-09	4	33	3	22277655
Pubmed	Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction.	CYBB NOX3 NOX1	7.77e-09	5	33	3	24608713
Pubmed	The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation.	CYBB NOX3 NOX1	1.55e-08	6	33	3	16775014
Pubmed	Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase.	CYBB NOX3 NOX1	2.72e-08	7	33	3	19005069
Pubmed	In the absence of reactive oxygen species, T cells default to a Th1 phenotype and mediate protection against pulmonary Cryptococcus neoformans infection.	CYBB NOX1	8.73e-07	2	33	2	17015737
Pubmed	The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation.	CYBB NOX1	8.73e-07	2	33	2	24494191
Pubmed	Adverse cognitive effects of high-fat diet in a murine model of sleep apnea are mediated by NADPH oxidase activity.	CYBB NOX1	8.73e-07	2	33	2	23064009
Pubmed	Netrin-1 abrogates ischemia/reperfusion-induced cardiac mitochondrial dysfunction via nitric oxide-dependent attenuation of NOX4 activation and recoupling of NOS.	CYBB NOX1	8.73e-07	2	33	2	25066694
Pubmed	The NADPH oxidase Nox2 regulates VEGFR1/CSF-1R-mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex.	CYBB NOX1	8.73e-07	2	33	2	23836548
Pubmed	NADPH Oxidases Are Essential for Macrophage Differentiation.	CYBB NOX1	8.73e-07	2	33	2	27489105
Pubmed	NADPH oxidase and the degeneration of dopaminergic neurons in parkinsonian mice.	CYBB NOX1	8.73e-07	2	33	2	24379900
Pubmed	Activation of NADPH oxidases leads to DNA damage in esophageal cells.	CYBB NOX1	8.73e-07	2	33	2	28855537
Pubmed	The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice.	CYBB NOX1	8.73e-07	2	33	2	16877542
Pubmed	NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice.	CYBB NOX1	8.73e-07	2	33	2	19661248
Pubmed	Redox modifier genes in amyotrophic lateral sclerosis in mice.	CYBB NOX1	8.73e-07	2	33	2	17853944
Pubmed	Anaerobic Respiration of NOX1-Derived Hydrogen Peroxide Licenses Bacterial Growth at the Colonic Surface.	CYBB NOX1	8.73e-07	2	33	2	33301718
Pubmed	Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis.	CYBB NOX1	8.73e-07	2	33	2	27212019
Pubmed	Endothelial NADPH oxidases: which NOX to target in vascular disease?	CYBB NOX1	8.73e-07	2	33	2	25066192
Pubmed	Ethanol induces oxidative stress in alveolar macrophages via upregulation of NADPH oxidases.	CYBB NOX1	8.73e-07	2	33	2	22412195
Pubmed	Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis.	CYBB NOX1	8.73e-07	2	33	2	26988594
Pubmed	VEO-IBD NOX1 variant highlights a structural region essential for NOX/DUOX catalytic activity.	CYBB NOX1	8.73e-07	2	33	2	37820403
Pubmed	NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion.	CYBB NOX1	2.62e-06	3	33	2	22933115
Pubmed	Intrarenal artery superoxide is mainly NADPH oxidase-derived and modulates endothelium-dependent dilation in elderly patients.	CYBB NOX1	2.62e-06	3	33	2	19843513
Pubmed	Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury.	CYBB NOX1	2.62e-06	3	33	2	36709665
Pubmed	Role of Nox isoforms in angiotensin II-induced oxidative stress and endothelial dysfunction in brain.	CYBB NOX1	2.62e-06	3	33	2	22628375
Pubmed	Receptor activator of nuclear factor-kappaB ligand-induced mouse osteoclast differentiation is associated with switching between NADPH oxidase homologues.	CYBB NOX1	2.62e-06	3	33	2	19409483
Pubmed	Amyloid β-induced astrogliosis is mediated by β1-integrin via NADPH oxidase 2 in Alzheimer's disease.	CYBB NOX1	2.62e-06	3	33	2	27709751
Pubmed	Gp91phox NADPH oxidase modulates litter size by regulating mucin1 in the uterus of mice.	CYBB NOX1	2.62e-06	3	33	2	28301257
Pubmed	Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.	CYBB NOX1	2.62e-06	3	33	2	23241962
Pubmed	Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase.	CYBB NOX1	2.62e-06	3	33	2	22456182
Pubmed	The NADPH Oxidase Nox2 Mediates Vitamin D-Induced Vascular Regeneration in Male Mice.	CYBB NOX1	2.62e-06	3	33	2	27399878
Pubmed	A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes.	CYBB NOX1	2.62e-06	3	33	2	15102091
Pubmed	NADPH Oxidases Are Required for Full Platelet Activation In Vitro and Thrombosis In Vivo but Dispensable for Plasma Coagulation and Hemostasis.	CYBB NOX1	2.62e-06	3	33	2	33267663
Pubmed	NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A.	CYBB NOX1	2.62e-06	3	33	2	18824544
Pubmed	Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury.	CYBB NOX1	2.62e-06	3	33	2	18397177
Pubmed	NADPH oxidase restrains the matrix metalloproteinase activity of macrophages.	CYBB NOX1	2.62e-06	3	33	2	15983040
Pubmed	Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling.	SNX14 SNX13	2.62e-06	3	33	2	25148684
Pubmed	NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7.	CYBB NOX1	2.62e-06	3	33	2	26116564
Pubmed	Perturbation of ubiquitin homeostasis promotes macrophage oxidative defenses.	CYBB NOX1	2.62e-06	3	33	2	31308397
Pubmed	Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors.	CYBB NOX1	2.62e-06	3	33	2	33836590
Pubmed	NADPH Oxidase and Guanylate Binding Protein 5 Restrict Survival of Avirulent Type III Strains of Toxoplasma gondii in Naive Macrophages.	CYBB NOX1	2.62e-06	3	33	2	30154263
Pubmed	NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis.	CYBB NOX1	2.62e-06	3	33	2	17761955
Pubmed	Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration.	CYBB NOX1	2.62e-06	3	33	2	20877715
Pubmed	Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases.	NOX3 NOX1	2.62e-06	3	33	2	16507994
Pubmed	Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy.	CYBB NOX1	2.62e-06	3	33	2	19471020
Pubmed	A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes.	NOX3 NOX1	2.62e-06	3	33	2	17336700
Pubmed	Alveolar macrophages from septic mice promote polymorphonuclear leukocyte transendothelial migration via an endothelial cell Src kinase/NADPH oxidase pathway.	CYBB NOX1	5.23e-06	4	33	2	19050294
Pubmed	Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin.	NEB SOS1	5.23e-06	4	33	2	12482578
Pubmed	NADPH oxidase Nox2 is required for hypoxia-induced mobilization of endothelial progenitor cells.	CYBB NOX1	5.23e-06	4	33	2	19679834
Pubmed	Cyba-deficient mice display an increase in hematopoietic stem cells and an overproduction of immunoglobulins.	CYBB NOX1	5.23e-06	4	33	2	31919083
Pubmed	Amplification of the inflammatory cellular redox state by human immunodeficiency virus type 1-immunosuppressive tat and gp160 proteins.	NOX3 NOX1	5.23e-06	4	33	2	9882350
Pubmed	The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes.	CYBB NOX1	8.72e-06	5	33	2	22549734
Pubmed	Macrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways.	CYBB NOX1	8.72e-06	5	33	2	25116588
Pubmed	Impaired OXPHOS complex III in breast cancer.	CYBB NOX3	8.72e-06	5	33	2	21901141
Pubmed	Influenza infection suppresses NADPH oxidase-dependent phagocytic bacterial clearance and enhances susceptibility to secondary methicillin-resistant Staphylococcus aureus infection.	CYBB NOX1	8.72e-06	5	33	2	24563256
Pubmed	Expression and modulation of an NADPH oxidase in mammalian astrocytes.	CYBB NOX1	8.72e-06	5	33	2	16207877
Pubmed	Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation.	CYBB NOX1	8.72e-06	5	33	2	34784249
Pubmed	The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA-/VacA- H. pylori.	CYBB NOX1	8.72e-06	5	33	2	27048452
Pubmed	Systemic regulation of vascular NAD(P)H oxidase activity and nox isoform expression in human arteries and veins.	CYBB NOX1	8.72e-06	5	33	2	15256399
Pubmed	Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.	CYBB NOX1	8.72e-06	5	33	2	22337127
Pubmed	Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.	CYBB NOX3 CCR3 NOX1	9.67e-06	141	33	4	20056178
Pubmed	Role of NADPH oxidase isoforms NOX1, NOX2 and NOX4 in myocardial ischemia/reperfusion injury.	CYBB NOX1	1.31e-05	6	33	2	24051369
Pubmed	Inhibition of NOX1 Mitigates Blood Pressure Increases in Elastin Insufficiency.	CYBB NOX1	1.31e-05	6	33	2	34223172
Pubmed	NOX isoforms in the development of abdominal aortic aneurysm.	CYBB NOX1	1.31e-05	6	33	2	27912196
Pubmed	Cooperative induction of CXCL10 involves NADPH oxidase: Implications for HIV dementia.	NOX3 NOX1	1.31e-05	6	33	2	19941336
Pubmed	The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye.	CYBB NOX1	1.31e-05	6	33	2	32483169
Pubmed	APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury.	CYBB NOX1	1.31e-05	6	33	2	28165467
Pubmed	Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases.	CYBB NOX1	1.83e-05	7	33	2	12716910
Pubmed	Rac1 mediates sex difference in cardiac tumor necrosis factor-alpha expression via NADPH oxidase-ERK1/2/p38 MAPK pathway in endotoxemia.	CYBB NOX1	1.83e-05	7	33	2	19450605
Pubmed	Riboflavin kinase couples TNF receptor 1 to NADPH oxidase.	CYBB NOX1	1.83e-05	7	33	2	19641494
Pubmed	Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase.	NOX3 NOX1	3.13e-05	9	33	2	15509740
Pubmed	Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells.	CYBB NOX1	3.13e-05	9	33	2	29884826
Pubmed	Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4.	CYBB NOX1	3.91e-05	10	33	2	21212270
Pubmed	Hepatocytes produce TNF-α following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner.	CYBB NOX1	3.91e-05	10	33	2	23639811
Pubmed	Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO.	CYBB NOX1	4.78e-05	11	33	2	30755476
Pubmed	Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome.	CYBB GLRA2	5.73e-05	12	33	2	1679744
Pubmed	Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.	FUT4 DHH	6.77e-05	13	33	2	32332736
Pubmed	Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome.	CYBB GLRA2	7.89e-05	14	33	2	8432533
Pubmed	Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation.	CYBB NOX1	1.04e-04	16	33	2	21029719
Pubmed	A large family of endosome-localized proteins related to sorting nexin 1.	SNX14 SNX13	1.18e-04	17	33	2	11485546
Pubmed	Sorting out the cellular functions of sorting nexins.	SNX14 SNX13	1.18e-04	17	33	2	12461558
Pubmed	A growth factor attenuates HIV-1 Tat and morphine induced damage to human neurons: implication in HIV/AIDS-drug abuse cases.	NOX3 NOX1	1.18e-04	17	33	2	21483469
Pubmed	Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis.	PIGQ PIGM	1.18e-04	17	33	2	11102867
Pubmed	Coordination of canonical and noncanonical Hedgehog signalling pathways mediated by WDR11 during primordial germ cell development.	FUT4 DHH	1.48e-04	19	33	2	37516749
Pubmed	Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome.	SESN2 HIRA	1.48e-04	19	33	2	19805316
Pubmed	Novel Cul3 binding proteins function to remodel E3 ligase complexes.	HIRA POC1B	6.66e-04	40	33	2	25011449
Pubmed	Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent.	CCR3 NEB	8.06e-04	44	33	2	26075897
Pubmed	Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.	NID2 DHH SMCHD1	8.49e-04	196	33	3	19334288
Pubmed	AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.	TSN NUP214 MARS1	9.00e-04	200	33	3	35546148
Pubmed	Multiple mouse chromosomal loci for dynein-based motility.	FUT4 NEB	9.19e-04	47	33	2	8812413
Cytoband	9q34.1	NUP214 FPGS	8.50e-05	19	33	2	9q34.1
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGQ PIGM	1.94e-04	21	18	2	680
GeneFamily	Sorting nexins\|PX-BAR domain containing	SNX14 SNX13	3.74e-04	29	18	2	754
GeneFamily	WD repeat domain containing	HIRA POC1B	2.75e-02	262	18	2	362
Drug	AG-012559 [369370-06-9]; Up 200; 10uM; MCF7; HT_HG-U133A	CYBB NOX1 NEB MARS1 SNX13 HIRA	3.44e-07	196	33	6	6889_UP
Drug	Eicosanoids	CYBB CASP12 NOX1	4.82e-06	23	33	3	ctd:D015777
Drug	Prednisone [53-03-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	NUP214 NOX1 TMEM259 MARS1 HIRA	8.55e-06	195	33	5	1478_DN
Drug	Oxolinic acid [14698-29-4]; Down 200; 15.4uM; MCF7; HT_HG-U133A	PIGQ NUP214 TMEM259 SNX13 HIRA	8.55e-06	195	33	5	2266_DN
Drug	diphenyline	CYBB NOX1	9.10e-05	10	33	2	CID000010292
Drug	Rilmenidine hemifumarate [54187-04-1]; Up 200; 8.4uM; MCF7; HT_HG-U133A	CYBB NUP214 PTPRT HIRA	1.66e-04	192	33	4	6512_UP
Drug	15(S)-15-methyl Prostaglandin E2; Up 200; 10uM; PC3; HT_HG-U133A	FUT4 TMEM259 SNX13 SOS1	1.66e-04	192	33	4	7526_UP
Drug	Rapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A	PIGQ FUT4 NEB TMEM259	1.69e-04	193	33	4	5602_DN
Drug	Adamantamine fumarate [80789-67-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	FUT4 NEB TMEM259 MARS1	1.72e-04	194	33	4	3280_DN
Drug	Bepridil hydrochloride [74764-40-2]; Down 200; 10uM; MCF7; HT_HG-U133A	NUP214 NEB TMEM259 HIRA	1.72e-04	194	33	4	5674_DN
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	NUP214 FPGS HIRA SOS1	1.76e-04	195	33	4	6966_DN
Drug	Solanine alpha [20562-02-1]; Down 200; 4.6uM; MCF7; HT_HG-U133A	SMCHD1 FPGS HIRA SOS1	1.76e-04	195	33	4	2808_DN
Drug	Tocopherol (R,S) [10191-41-0]; Down 200; 9.2uM; MCF7; HT_HG-U133A	TMEM259 SMCHD1 FPGS SNX13	1.76e-04	195	33	4	4961_DN
Drug	Procyclidine hydrochloride [1508-76-5]; Down 200; 12.4uM; MCF7; HT_HG-U133A	PIGQ NOX1 SNX13 HIRA	1.76e-04	195	33	4	3330_DN
Drug	Coralyne chloride hydrate [38989-38-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A	NOX1 NEB MARS1 HIRA	1.79e-04	196	33	4	5418_DN
Drug	Sulfaphenazole [526-08-9]; Up 200; 12.8uM; MCF7; HT_HG-U133A	PIGQ TMEM259 MARS1 HIRA	1.79e-04	196	33	4	1673_UP
Drug	Tocopherol (R,S) [10191-41-0]; Up 200; 9.2uM; MCF7; HT_HG-U133A	PIGQ FUT4 MARS1 SOS1	1.79e-04	196	33	4	3256_UP
Drug	Metixene hydrochloride [1553-34-0]; Up 200; 11.6uM; HL60; HT_HG-U133A	NUP214 NOX1 TMEM259 SOS1	1.79e-04	196	33	4	2451_UP
Drug	Cyclobenzaprine hydrochloride [6202-23-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A	PIGQ TMEM259 MARS1 FPGS	1.79e-04	196	33	4	4834_DN
Drug	Meclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; MCF7; HT_HG-U133A	PIGQ FUT4 MARS1 SMCHD1	1.79e-04	196	33	4	3277_UP
Drug	Moricizine hydrochloride [31883-05-3]; Up 200; 8.6uM; MCF7; HT_HG-U133A	NOX3 NUP214 NEB SNX13	1.79e-04	196	33	4	6000_UP
Drug	0393-0188; Down 200; 10uM; PC3; HT_HG-U133A	TMEM259 SMCHD1 HIRA SOS1	1.83e-04	197	33	4	7510_DN
Drug	Triamcinolone [124-94-7]; Up 200; 10.2uM; PC3; HT_HG-U133A	NUP214 FUT4 HIRA SOS1	1.83e-04	197	33	4	5835_UP
Drug	Sulfamonomethoxine [1220-83-3]; Up 200; 14.2uM; PC3; HT_HG-U133A	NEB SNX13 HIRA SOS1	1.83e-04	197	33	4	5843_UP
Drug	Flunarizine dihydrochloride [30484-77-6]; Up 200; 8.4uM; MCF7; HT_HG-U133A	PIGQ FUT4 NEB MARS1	1.83e-04	197	33	4	7412_UP
Drug	Epirizole [18694-40-1]; Up 200; 17uM; PC3; HT_HG-U133A	CYBB NOX1 TMEM259 MARS1	1.83e-04	197	33	4	7292_UP
Drug	nordihydroguaiaretic acid; Up 200; 1uM; PC3; HT_HG-U133A	NOX1 TMEM259 MARS1 FPGS	1.83e-04	197	33	4	1223_UP
Drug	Vinpocetine [42971-09-5]; Down 200; 11.4uM; MCF7; HT_HG-U133A	CYBB TMEM259 MARS1 SNX13	1.83e-04	197	33	4	3174_DN
Drug	Bendroflumethiazide [73-48-3]; Up 200; 9.4uM; PC3; HT_HG-U133A	CYBB NOX1 TMEM259 PTPRT	1.83e-04	197	33	4	4315_UP
Drug	(-)-MK 801 hydrogen maleate [77086-19-2]; Up 200; 11.8uM; MCF7; HT_HG-U133A	CYBB NOX3 NOX1 SOS1	1.86e-04	198	33	4	6458_UP
Drug	Sulfasalazine [599-79-1]; Up 200; 10uM; MCF7; HT_HG-U133A	NUP214 NOX1 MARS1 GLRA2	1.86e-04	198	33	4	5446_UP
Drug	Cotinine (-) [486-56-6]; Down 200; 22.6uM; MCF7; HT_HG-U133A	FUT4 TMEM259 SMCHD1 SNX13	1.86e-04	198	33	4	5611_DN
Drug	Thonzonium bromide [553-08-2]; Down 200; 6.8uM; MCF7; HT_HG-U133A	PIGQ NEB TMEM259 SNX13	1.86e-04	198	33	4	5678_DN
Drug	Doxycycline hydrochloride [10592-13-9]; Up 200; 8.4uM; PC3; HT_HG-U133A	NUP214 NEB SNX13 SOS1	1.86e-04	198	33	4	5838_UP
Drug	Gliclazide [21187-98-4]; Up 200; 12.4uM; MCF7; HT_HG-U133A	NUP214 NOX1 TMEM259 SNX13	1.86e-04	198	33	4	5514_UP
Drug	(-)-MK 801 hydrogen maleate [77086-19-2]; Up 200; 11.8uM; PC3; HT_HG-U133A	PIGQ NOX1 SNX13 HIRA	1.86e-04	198	33	4	6657_UP
Drug	Lasalocid sodium salt [25999-20-6]; Down 200; 6.6uM; MCF7; HT_HG-U133A	NOX1 FUT4 NEB SNX13	1.90e-04	199	33	4	3360_DN
Drug	Methapyrilene hydrochloride [135-23-9]; Up 200; 13.4uM; MCF7; HT_HG-U133A	NUP214 NOX1 FUT4 NEB	1.90e-04	199	33	4	4990_UP
Drug	Tobramycin [32986-56-4]; Down 200; 8.6uM; MCF7; HT_HG-U133A	NEB TMEM259 MARS1 SNX13	1.90e-04	199	33	4	2841_DN
Drug	78 h	MARS1 FPGS	2.11e-04	15	33	2	CID000095054
Drug	dalcetrapib	CYBB NOX1	2.11e-04	15	33	2	ctd:C411602
Disease	L2 Acute Lymphoblastic Leukemia	NUP214 FPGS	1.44e-03	50	33	2	C0023453
Disease	Childhood Acute Lymphoblastic Leukemia	NUP214 FPGS	1.55e-03	52	33	2	C0023452
Disease	creatine kinase measurement	NEB SNX13	1.99e-03	59	33	2	EFO_0004534
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	NUP214 FPGS	2.13e-03	61	33	2	C1961102

Protein segments in the cluster

Peptide	Gene	Start	Entry
IYYFREYSWSHHLEE	CASP12	291	Q6UXS9
HVFRWLAYSYASTHR	CPXM2	546	Q8N436
ILLDYYLWDYAHDHR	C9orf64	311	Q5T6V5
EIVRDHWAKFGRHYY	PGM5	416	Q15124
IRRSYFEVFWYTHHL	NOX1	196	Q9Y5S8
VYRRYFHWRRSYAVH	FUT4	481	P22083
LYYRVVRAHEDAWHI	PEAK3	186	Q6ZS72
RQHHYYLSYIEEWDL	NUP214	301	P35658
FLYSLYRHTHWVRCA	POC1B	136	Q8TC44
YHEIRELRLFHFTSW	PTPRT	1036	O14522
IVSYADHFYHTDWRR	NID2	1321	Q14112
LYPEDTVYSWRHFHT	CCR3	186	P51677
FDWVYYESRNHVHVS	DHH	171	O43323
IRHTAEYQEHWFYFE	ADPRHL1	211	Q8NDY3
YDRAFPVSHYRFWLF	GJD3	66	Q8N144
FYWITYKIIRHEDVH	GLRA2	436	P23416
KRHWLRFFYLYHFAF	TMEM259	401	Q4ZIN3
TIRRSYFEVFWYTHH	CYBB	196	P04839
LFTKYFWRLYHRLEE	FPGS	151	Q05932
SSHEYRHWLLVYARY	HIRA	931	P54198
MWKTYRRYSDFHDFH	SNX13	606	Q9Y5W8
HPDYFTSFWRLHYLL	SESN2	86	P58004
LWTRQLAHIYHYYIH	SMCHD1	341	A6NHR9
RFFLYHIHLWISYIH	PIGQ	346	Q9BRB3
HERFSDHYYDTSWKR	ST6GALNAC1	546	Q9NSC7
WVEHHFYDFERDAYL	SOS1	696	Q07889
RQASYELFWYTHHVF	NOX3	196	Q9HBY0
WTRFFQSHYFHRDRL	GTF2H1	221	P32780
HEPEHWSVYRRYLEF	SNX14	606	Q9Y5W7
WEFLEHTYFYHLTRR	PIGM	251	Q9H3S5
YDVVHRWYTAHRTLT	TMLHE	346	Q9NVH6
YHIIHADIYRWFNIS	MARS1	336	P56192
AEQYYRFHEHWRFVL	TSN	81	Q15631
YILSDLEYRHYFHQW	NEB	4561	P20929
LEYRHYFHQWTSLLE	NEB	4566	P20929