Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription corepressor activity

SSX5 SSX3 SSX9P TSG101 SSX7

4.26e-06229225GO:0003714
GeneOntologyMolecularFunctiontranscription coregulator activity

SSX5 SSX3 SSX9P TSG101 SSX7

3.07e-04562225GO:0003712
GeneOntologyMolecularFunctionATP-dependent activity

MYO7A MYO10 AK9 NLRP3 DHX33

4.61e-04614225GO:0140657
GeneOntologyMolecularFunctionspectrin binding

MYO7A MYO10

6.36e-0434222GO:0030507
GeneOntologyMolecularFunctionmicrofilament motor activity

MYO7A MYO10

7.95e-0438222GO:0000146
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

SSX5 SSX3 SSX9P TSG101 NLRP3 SSX7

1.26e-031160226GO:0030674
GeneOntologyMolecularFunctionADP binding

MYO7A NLRP3

1.27e-0348222GO:0043531
GeneOntologyMolecularFunctionphosphotyrosine residue binding

SYK CBLB

1.43e-0351222GO:0001784
GeneOntologyMolecularFunctionprotein phosphorylated amino acid binding

SYK CBLB

2.60e-0369222GO:0045309
GeneOntologyMolecularFunctionmolecular adaptor activity

SSX5 SSX3 SSX9P TSG101 NLRP3 SSX7

2.81e-031356226GO:0060090
GeneOntologyBiologicalProcessregulation of type I interferon production

SYK POLA1 SETD2 DHX33

1.39e-05141224GO:0032479
GeneOntologyBiologicalProcesstype I interferon production

SYK POLA1 SETD2 DHX33

1.55e-05145224GO:0032606
GeneOntologyBiologicalProcesscellular response to peptidoglycan

RELA NLRP3

3.03e-058222GO:0071224
GeneOntologyBiologicalProcesspositive regulation of type I interferon production

SYK SETD2 DHX33

8.51e-0581223GO:0032481
GeneOntologyBiologicalProcessnegative regulation of epidermal growth factor-activated receptor activity

CBLB TSG101

1.13e-0415222GO:0007175
GeneOntologyBiologicalProcessresponse to peptidoglycan

RELA NLRP3

1.46e-0417222GO:0032494
GeneOntologyBiologicalProcessimmune response-activating signaling pathway

SYK CBLB RELA NLRP3 DHX33

2.45e-04553225GO:0002757
GeneOntologyBiologicalProcessregulation of epidermal growth factor-activated receptor activity

CBLB TSG101

2.48e-0422222GO:0007176
GeneOntologyBiologicalProcessinnate immune response-activating signaling pathway

SYK RELA NLRP3 DHX33

3.03e-04312224GO:0002758
GeneOntologyBiologicalProcessregulation of cell-cell adhesion

SYK CBLB MYO10 RELA NLRP3

3.06e-04580225GO:0022407
GeneOntologyBiologicalProcesspositive regulation of cytokine production

SYK SETD2 RELA NLRP3 DHX33

3.21e-04586225GO:0001819
GeneOntologyBiologicalProcessactivation of innate immune response

SYK RELA NLRP3 DHX33

3.88e-04333224GO:0002218
GeneOntologyBiologicalProcessimmune response-regulating signaling pathway

SYK CBLB RELA NLRP3 DHX33

4.01e-04615225GO:0002764
GeneOntologyBiologicalProcessactivation of immune response

SYK CBLB RELA NLRP3 DHX33

4.25e-04623225GO:0002253
GeneOntologyBiologicalProcessregulation of alpha-beta T cell activation

SYK CBLB NLRP3

4.38e-04141223GO:0046634
GeneOntologyBiologicalProcesspositive regulation of interleukin-4 production

SYK NLRP3

4.64e-0430222GO:0032753
GeneOntologyBiologicalProcessnegative regulation of protein tyrosine kinase activity

CBLB TSG101

4.64e-0430222GO:0061099
GeneOntologyBiologicalProcessregulation of cytokine production

SYK POLA1 SETD2 RELA NLRP3 DHX33

5.15e-041010226GO:0001817
GeneOntologyBiologicalProcessnegative regulation of epidermal growth factor receptor signaling pathway

CBLB TSG101

5.28e-0432222GO:0042059
GeneOntologyBiologicalProcesspositive regulation of NF-kappaB transcription factor activity

RELA NLRP3 DHX33

5.35e-04151223GO:0051092
GeneOntologyBiologicalProcessnegative regulation of signaling receptor activity

CBLB TSG101

5.62e-0433222GO:2000272
GeneOntologyBiologicalProcesspositive regulation of cell-cell adhesion

SYK MYO10 RELA NLRP3

6.96e-04389224GO:0022409
GeneOntologyBiologicalProcessnegative regulation of ERBB signaling pathway

CBLB TSG101

7.07e-0437222GO:1901185
GeneOntologyBiologicalProcesscytokine production

SYK POLA1 SETD2 RELA NLRP3 DHX33

7.75e-041091226GO:0001816
GeneOntologyBiologicalProcessregulation of interleukin-4 production

SYK NLRP3

7.86e-0439222GO:0032673
GeneOntologyBiologicalProcesspositive regulation of innate immune response

SYK RELA NLRP3 DHX33

9.27e-04420224GO:0045089
GeneOntologyBiologicalProcessnegative regulation of non-canonical NF-kappaB signal transduction

RELA NLRP3

9.55e-0443222GO:1901223
GeneOntologyBiologicalProcesscytoplasmic pattern recognition receptor signaling pathway

RELA NLRP3 DHX33

1.01e-03188223GO:0002753
GeneOntologyBiologicalProcessNLRP3 inflammasome complex assembly

NLRP3 DHX33

1.09e-0346222GO:0044546
GeneOntologyBiologicalProcessinterleukin-4 production

SYK NLRP3

1.14e-0347222GO:0032633
GeneOntologyBiologicalProcessregulation of leukocyte cell-cell adhesion

SYK CBLB RELA NLRP3

1.17e-03447224GO:1903037
GeneOntologyBiologicalProcessregulation of DNA-binding transcription factor activity

SYK RELA NLRP3 DHX33

1.19e-03449224GO:0051090
GeneOntologyBiologicalProcesscanonical inflammasome complex assembly

NLRP3 DHX33

1.19e-0348222GO:0140632
GeneOntologyBiologicalProcesspositive regulation of response to biotic stimulus

SYK RELA NLRP3 DHX33

1.21e-03451224GO:0002833
GeneOntologyBiologicalProcesspositive regulation of interleukin-12 production

SYK RELA

1.24e-0349222GO:0032735
GeneOntologyBiologicalProcessepidermis development

MYO7A RELA TSG101 PTPRQ

1.31e-03461224GO:0008544
GeneOntologyBiologicalProcessinflammasome-mediated signaling pathway

NLRP3 DHX33

1.45e-0353222GO:0141084
GeneOntologyBiologicalProcessregulation of alpha-beta T cell proliferation

SYK CBLB

1.45e-0353222GO:0046640
GeneOntologyBiologicalProcessregulation of T cell receptor signaling pathway

CBLB RELA

1.56e-0355222GO:0050856
GeneOntologyBiologicalProcessleukocyte cell-cell adhesion

SYK CBLB RELA NLRP3

1.59e-03486224GO:0007159
GeneOntologyBiologicalProcessnegative regulation of protein kinase activity

CBLB TSG101 PTPRQ

1.61e-03221223GO:0006469
GeneOntologyBiologicalProcessantigen receptor-mediated signaling pathway

SYK CBLB RELA

1.65e-03223223GO:0050851
GeneOntologyBiologicalProcesspositive regulation of immune response

SYK CBLB RELA NLRP3 DHX33

1.68e-03845225GO:0050778
GeneOntologyBiologicalProcessalpha-beta T cell activation

SYK CBLB NLRP3

1.74e-03227223GO:0046631
GeneOntologyBiologicalProcessalpha-beta T cell proliferation

SYK CBLB

1.79e-0359222GO:0046633
GeneOntologyBiologicalProcessnegative regulation of peptidyl-tyrosine phosphorylation

CBLB TSG101

1.79e-0359222GO:0050732
GeneOntologyBiologicalProcessnegative regulation of protein modification process

CBLB RELA TSG101 PTPRQ

1.92e-03512224GO:0031400
GeneOntologyBiologicalProcessnegative regulation of kinase activity

CBLB TSG101 PTPRQ

1.94e-03236223GO:0033673
GeneOntologyBiologicalProcessregulation of innate immune response

SYK RELA NLRP3 DHX33

2.02e-03519224GO:0045088
GeneOntologyBiologicalProcesspositive regulation of alpha-beta T cell differentiation

SYK NLRP3

2.10e-0364222GO:0046638
GeneOntologyBiologicalProcesspositive regulation of interleukin-8 production

SYK RELA

2.30e-0367222GO:0032757
GeneOntologyBiologicalProcessregulation of protein tyrosine kinase activity

CBLB TSG101

2.44e-0369222GO:0061097
GeneOntologyBiologicalProcessregulation of cell adhesion

SYK CBLB MYO10 RELA NLRP3

2.52e-03927225GO:0030155
GeneOntologyBiologicalProcessregulation of interleukin-12 production

SYK RELA

2.58e-0371222GO:0032655
GeneOntologyBiologicalProcesspositive regulation of DNA-binding transcription factor activity

RELA NLRP3 DHX33

2.58e-03261223GO:0051091
GeneOntologyBiologicalProcesspositive regulation of non-canonical NF-kappaB signal transduction

RELA NLRP3

2.65e-0372222GO:1901224
GeneOntologyBiologicalProcessmyeloid leukocyte cytokine production

SYK NLRP3

2.65e-0372222GO:0061082
GeneOntologyBiologicalProcessinner ear receptor cell development

MYO7A PTPRQ

2.73e-0373222GO:0060119
GeneOntologyBiologicalProcessinterleukin-12 production

SYK RELA

2.73e-0373222GO:0032615
GeneOntologyBiologicalProcesspositive regulation of interleukin-1 beta production

RELA NLRP3

2.80e-0374222GO:0032731
GeneOntologyBiologicalProcessneuromuscular process controlling balance

MYO7A PTPRQ

2.80e-0374222GO:0050885
GeneOntologyBiologicalProcessregulation of peptidyl-tyrosine phosphorylation

SYK CBLB TSG101

2.90e-03272223GO:0050730
GeneOntologyBiologicalProcessnegative regulation of transferase activity

CBLB TSG101 PTPRQ

2.93e-03273223GO:0051348
GeneOntologyBiologicalProcesspositive regulation of cell adhesion

SYK MYO10 RELA NLRP3

3.01e-03579224GO:0045785
GeneOntologyBiologicalProcessregulation of antigen receptor-mediated signaling pathway

CBLB RELA

3.03e-0377222GO:0050854
GeneOntologyBiologicalProcesspositive regulation of cellular component biogenesis

SYK PAN2 TSG101 DHX33

3.06e-03582224GO:0044089
GeneOntologyBiologicalProcesshair cell differentiation

MYO7A PTPRQ

3.11e-0378222GO:0035315
GeneOntologyBiologicalProcesspeptidyl-amino acid modification

SYK CBLB SETD2 RELA TSG101

3.15e-03976225GO:0018193
GeneOntologyBiologicalProcesspositive regulation of defense response

SYK RELA NLRP3 DHX33

3.20e-03589224GO:0031349
GeneOntologyBiologicalProcessepidermal cell differentiation

MYO7A TSG101 PTPRQ

3.28e-03284223GO:0009913
GeneOntologyCellularComponentstereocilium base

MYO7A PTPRQ

2.95e-058222GO:0120044
GeneOntologyCellularComponentNLRP3 inflammasome complex

NLRP3 DHX33

2.95e-058222GO:0072559
GeneOntologyCellularComponentsperm flagellum

SSX5 SSX3 SSX9P SSX7

6.76e-05214224GO:0036126
GeneOntologyCellularComponent9+2 motile cilium

SSX5 SSX3 SSX9P SSX7

1.02e-04238224GO:0097729
GeneOntologyCellularComponentcanonical inflammasome complex

NLRP3 DHX33

1.60e-0418222GO:0061702
GeneOntologyCellularComponentcilium

SSX5 SSX3 MYO7A SSX9P CCDC178 SSX7

2.55e-04898226GO:0005929
GeneOntologyCellularComponentmotile cilium

SSX5 SSX3 SSX9P SSX7

4.70e-04355224GO:0031514
GeneOntologyCellularComponentmyosin complex

MYO7A MYO10

1.74e-0359222GO:0016459
GeneOntologyCellularComponentrough endoplasmic reticulum

RPL6 MACO1

2.05e-0364222GO:0005791
GeneOntologyCellularComponentstereocilium

MYO7A PTPRQ

2.38e-0369222GO:0032420
GeneOntologyCellularComponentactin-based cell projection

MYO7A MYO10 PTPRQ

2.97e-03278223GO:0098858
GeneOntologyCellularComponentstereocilium bundle

MYO7A PTPRQ

3.10e-0379222GO:0032421
MousePhenoabnormal orientation of inner hair cell stereociliary bundles

MYO7A PTPRQ

8.05e-0512162MP:0004492
MousePhenofused inner hair cell stereocilia

MYO7A PTPRQ

8.05e-0512162MP:0004533
MousePhenodecreased inner hair cell stereocilia number

MYO7A PTPRQ

9.51e-0513162MP:0004534
MousePhenoshort cochlear hair cell stereocilia

MYO7A PTPRQ

1.65e-0417162MP:0004524
MousePhenoabnormal vestibular hair cell stereociliary bundle morphology

MYO7A PTPRQ

2.80e-0422162MP:0004515
MousePhenoincreased susceptibility to age-related hearing loss

MYO7A PTPRQ

3.06e-0423162MP:0004748
MousePhenodecreased cochlear hair cell stereocilia number

MYO7A PTPRQ

3.93e-0426162MP:0004523
DomainKRAB_RELATED

SSX5 SSX3 SSX9P SSX7

2.51e-1011194PS50806
DomainKrueppel-associated_box-rel

SSX5 SSX3 SSX9P SSX7

5.44e-1013194IPR003655
DomainSSX

SSX5 SSX3 SSX7

1.78e-086193IPR028804
DomainSSXRD

SSX5 SSX3 SSX7

4.98e-088193PF09514
DomainSSXRD_motif

SSX5 SSX3 SSX7

4.98e-088193IPR019041
DomainMYTH4

MYO7A MYO10

3.51e-059192PS51016
DomainMyTH4_dom

MYO7A MYO10

3.51e-059192IPR000857
DomainMyTH4

MYO7A MYO10

3.51e-059192SM00139
DomainMyTH4

MYO7A MYO10

3.51e-059192PF00784
DomainKRAB

SSX5 SSX3 SSX9P SSX7

4.59e-04369194SM00349
DomainKRAB

SSX5 SSX3 SSX9P SSX7

4.64e-04370194IPR001909
DomainMYOSIN_MOTOR

MYO7A MYO10

6.74e-0438192PS51456
DomainMyosin_head

MYO7A MYO10

6.74e-0438192PF00063
DomainMyosin_head_motor_dom

MYO7A MYO10

6.74e-0438192IPR001609
DomainMYSc

MYO7A MYO10

6.74e-0438192SM00242
DomainFERM_M

MYO7A MYO10

9.88e-0446192PF00373
Domain-

PAN2 POLA1

1.03e-03471923.30.420.10
DomainFERM_central

MYO7A MYO10

1.12e-0349192IPR019748
DomainFERM_domain

MYO7A MYO10

1.12e-0349192IPR000299
Domain-

MYO7A MYO10

1.12e-03491921.20.80.10
DomainFERM_1

MYO7A MYO10

1.17e-0350192PS00660
DomainFERM_2

MYO7A MYO10

1.17e-0350192PS00661
DomainBand_41_domain

MYO7A MYO10

1.17e-0350192IPR019749
DomainB41

MYO7A MYO10

1.17e-0350192SM00295
DomainFERM/acyl-CoA-bd_prot_3-hlx

MYO7A MYO10

1.17e-0350192IPR014352
DomainFERM_3

MYO7A MYO10

1.17e-0350192PS50057
DomainP-loop_NTPase

MYO7A MYO10 AK9 NLRP3 DHX33

1.30e-03848195IPR027417
DomainRNaseH-like_dom

PAN2 POLA1

2.21e-0369192IPR012337
DomainIQ

MYO7A MYO10

2.34e-0371192PF00612
DomainIQ

MYO7A MYO10

3.03e-0381192SM00015
DomainIQ_motif_EF-hand-BS

MYO7A MYO10

3.72e-0390192IPR000048
DomainIQ

MYO7A MYO10

3.97e-0393192PS50096
DomainSH2

SYK CBLB

5.51e-03110192SM00252
DomainSH2

SYK CBLB

5.60e-03111192PS50001
DomainSH2

SYK CBLB

5.70e-03112192IPR000980
Domain-

SYK CBLB

5.70e-031121923.30.505.10
PathwayWP_FIBRIN_COMPLEMENT_RECEPTOR_3_SIGNALING

SYK CBLB RELA

9.40e-0643143M39744
PathwayWP_FIBRIN_COMPLEMENT_RECEPTOR_3_SIGNALING_PATHWAY

SYK CBLB RELA

1.31e-0548143MM15897
PathwayWP_ACTIVATION_OF_NLRP3_INFLAMMASOME_BY_SARSCOV2

RELA NLRP3

1.92e-057142M39874
PathwayPID_FCER1_PATHWAY

SYK CBLB RELA

2.58e-0560143M7
PathwayREACTOME_LEISHMANIA_INFECTION

SYK MYO10 RELA NLRP3

5.02e-05219144M29836
PathwayREACTOME_THE_NLRP3_INFLAMMASOME

RELA NLRP3

1.09e-0416142M1063
PathwayPID_NFKAPPAB_ATYPICAL_PATHWAY

SYK RELA

1.24e-0417142M26
PathwayREACTOME_INFLAMMASOMES

RELA NLRP3

1.90e-0421142M1072
PathwayWP_STING_PATHWAY_IN_KAWASAKILIKE_DISEASE_AND_COVID19

RELA NLRP3

1.90e-0421142M40061
PathwayREACTOME_PURINERGIC_SIGNALING_IN_LEISHMANIASIS_INFECTION

RELA NLRP3

2.94e-0426142M29838
PathwayREACTOME_INFECTIOUS_DISEASE

SYK MYO10 RPL6 RELA TSG101 NLRP3

3.52e-041081146M27548
PathwayPID_AVB3_OPN_PATHWAY

SYK RELA

4.19e-0431142M63
PathwayPID_CD40_PATHWAY

CBLB RELA

4.19e-0431142M45
PathwayPID_ERBB1_INTERNALIZATION_PATHWAY

CBLB TSG101

7.35e-0441142M214
PathwayWP_NUCLEOTIDEBINDING_OLIGOMERIZATION_DOMAIN_NOD_PATHWAY

RELA NLRP3

7.35e-0441142M39698
PathwayREACTOME_SARS_COV_1_ACTIVATES_MODULATES_INNATE_IMMUNE_RESPONSES

RELA NLRP3

7.35e-0441142M46425
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

SETD2 RELA

9.25e-0446142MM14933
PathwayREACTOME_VIRAL_INFECTION_PATHWAYS

SYK RPL6 RELA TSG101 NLRP3

1.22e-03888145M48034
PathwayWP_RANKLRANK_SIGNALING

SYK RELA

1.32e-0355142M39667
PathwayREACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS

RELA NLRP3

1.37e-0356142M1074
PathwayWP_MODULATORS_OF_TCR_SIGNALING_AND_T_CELL_ACTIVATION

CBLB RELA

1.62e-0361142M42548
PathwayKEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY

RELA NLRP3

1.67e-0362142M15569
PathwayPID_BCR_5PATHWAY

SYK RELA

1.73e-0363142M10
Pubmed

Identification and characterization of mouse SSX genes: a multigene family on the X chromosome with restricted cancer/testis expression.

SSX5 SSX3 SSX9P SSX7

1.51e-11922414611804
Pubmed

The SSX gene family: characterization of 9 complete genes.

SSX5 SSX3 SSX9P SSX7

7.13e-102122412216073
Pubmed

Genipin alleviates LPS-induced acute lung injury by inhibiting NF-κB and NLRP3 signaling pathways.

RELA NLRP3

3.82e-07222227262946
Pubmed

Inhibition of CBLB protects from lethal Candida albicans sepsis.

SYK CBLB

3.82e-07222227428901
Pubmed

The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome.

NLRP3 DHX33

3.82e-07222223871209
Pubmed

Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation.

RELA NLRP3

3.82e-07222226937141
Pubmed

A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles.

MYO7A PTPRQ

3.82e-07222214534255
Pubmed

SYK kinase signaling and the NLRP3 inflammasome in antifungal immunity.

SYK NLRP3

3.82e-07222220401456
Pubmed

NF-κB downregulates Cbl-b through binding and suppressing Cbl-b promoter in T cell activation.

CBLB RELA

3.82e-07222225762784
Pubmed

Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase.

SYK NLRP3

3.82e-07222220368800
Pubmed

NLRP3 inflammasome activation from Kupffer cells is involved in liver fibrosis of Schistosoma japonicum-infected mice via NF-κB.

RELA NLRP3

3.82e-07222230635040
Pubmed

NLRP3 inflammasome activation results in liver inflammation and fibrosis in mice infected with Schistosoma japonicum in a Syk-dependent manner.

SYK NLRP3

3.82e-07222228808303
Pubmed

Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase.

SYK NLRP3

1.15e-06322222854286
Pubmed

NLRX1 modulates differentially NLRP3 inflammasome activation and NF-κB signaling during Fusobacterium nucleatum infection.

RELA NLRP3

1.15e-06322229024797
Pubmed

PKR induces the expression of NLRP3 by regulating the NF-κB pathway in Porphyromonas gingivalis-infected osteoblasts.

RELA NLRP3

1.15e-06322228341446
Pubmed

Tripartite-motif protein 21 knockdown extenuates LPS-triggered neurotoxicity by inhibiting microglial M1 polarization via suppressing NF-κB-mediated NLRP3 inflammasome activation.

RELA NLRP3

1.15e-06322233992596
Pubmed

Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk.

SYK CBLB

1.15e-06322212771181
Pubmed

A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss.

MYO7A PTPRQ

1.15e-06322220451170
Pubmed

Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65.

SYK RELA

2.29e-06422218362147
Pubmed

Expressions of cancer-testis antigens in human hepatocellular carcinomas.

SSX5 SSX7

2.29e-06422211179834
Pubmed

Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1.

SYK NLRP3

2.29e-06422221876553
Pubmed

Vertebrate unconventional myosins.

MYO7A MYO10

2.29e-0642228690736
Pubmed

TLR-induced NF-κB activation regulates NLRP3 expression in murine macrophages.

RELA NLRP3

2.29e-06422222569257
Pubmed

The pattern-recognition molecule mindin binds integrin Mac-1 to promote macrophage phagocytosis via Syk activation and NF-κB p65 translocation.

SYK RELA

2.29e-06422230869196
Pubmed

Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization.

SYK NLRP3

2.29e-06422225605870
Pubmed

Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines.

SSX5 SSX3

2.29e-06422210749136
Pubmed

Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase.

SYK RELA

2.29e-06422212711606
Pubmed

SSX: a multigene family with several members transcribed in normal testis and human cancer.

SSX5 SSX3

3.82e-0652229378559
Pubmed

Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation.

SYK CBLB

3.82e-06522210022120
Pubmed

Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b.

SYK CBLB

5.72e-06622217493844
Pubmed

Tails of unconventional myosins.

MYO7A MYO10

8.01e-06722211212352
Pubmed

Phospholipase Cγ2 (PLCγ2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses.

SYK RELA

1.07e-05822222041900
Pubmed

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.

SYK NLRP3

1.07e-05822219339971
Pubmed

The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP.

SSX5 SSX3

1.07e-05822212007189
Pubmed

Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation.

RELA NLRP3

1.07e-05822233460751
Pubmed

The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis.

SYK NLRP3

1.07e-05822231719149
Pubmed

FcγR mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes.

SYK NLRP3

1.07e-05822227365531
Pubmed

The E3 ubiquitin ligase tripartite motif 33 is essential for cytosolic RNA-induced NLRP3 inflammasome activation.

NLRP3 DHX33

1.07e-05822225172487
Pubmed

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins.

CBLB TSG101

1.37e-05922214973438
Pubmed

An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma.

SYK NLRP3

1.71e-051022221474346
Pubmed

Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia.

CBLB NLRP3

2.09e-051122231999304
Pubmed

TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis.

RELA NLRP3

2.97e-051322221464320
Pubmed

Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection.

SYK NLRP3

3.46e-051422230510167
Pubmed

Targeting TRIM3 deletion-induced tumor-associated lymphangiogenesis prohibits lymphatic metastasis in esophageal squamous cell carcinoma.

RPL6 RELA

3.46e-051422230542119
Pubmed

Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein.

MYO7A PTPRQ

3.46e-051422215653467
Pubmed

Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.

MYO7A PTPRQ

4.56e-051622217567809
Pubmed

Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis.

SYK NLRP3

4.56e-051622231169521
Pubmed

The DNA sequence of the human X chromosome.

SSX5 SSX3 SSX9P SSX7

1.14e-0440722415772651
Pubmed

The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route.

MYO7A MYO10

1.87e-043222223704327
Pubmed

A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.

SSX5 SSX3 SSX7

2.86e-0420522312040188
Pubmed

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.

MYO7A PTPRQ

3.56e-044422227534441
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

MYO10 RPL6 SETD2 RELA TSG101

4.04e-04103822526673895
Pubmed

Mapping of unconventional myosins in mouse and human.

MYO7A MYO10

4.23e-04482228884266
Pubmed

A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.

SYK CCDC178

4.97e-045222222219177
Pubmed

CIN85 interacting proteins in B cells-specific role for SHIP-1.

CBLB TSG101

5.36e-045422221725061
Pubmed

Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.

POLA1 SETD2 NLRP3

5.54e-0425722330945288
InteractionGLG1 interactions

SYK PAN2 RPL6 RELA

1.17e-05132224int:GLG1
InteractionSSX2 interactions

SSX5 SSX3 SSX7

1.56e-0545223int:SSX2
InteractionSSX7 interactions

SSX3 SSX7

6.22e-0511222int:SSX7
CytobandXp11.23

SSX5 SSX3 SSX9P SSX7

1.22e-0795224Xp11.23
CytobandEnsembl 112 genes in cytogenetic band chrXp11

SSX5 SSX3 SSX9P SSX7

2.91e-05377224chrXp11
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

MYO7A MYO10

7.69e-04501521293
GeneFamilyActins|Deafness associated genes

MYO7A PTPRQ

3.85e-031131521152
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

CBLB MACO1 CCDC168 CCDC178

8.07e-07149224768877bade04ca0321593b8470b5011ad8270431
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CBLB CCDC168 PTPRQ

6.35e-05159223fd7db2f7328cfefdc3ada2af91006d5a91d137e1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CBLB CCDC168 PTPRQ

6.35e-05159223aaf449c768d6fbb0a1bb47746ff3bdb7f9eb8914
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CBLB CCDC168 PTPRQ

6.35e-051592238bbdef1e927f3130b578d7d7c5ff38bbe06fab63
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CBLB MYO10 CHST12

1.01e-04186223facc1bd8920003ad03d1893c32fc606d82b4d50a
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SYK MYO7A NLRP3

1.03e-0418722339b99f46b723f7f3c44880d7fe8642cbad558b8a
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

SYK MYO7A NLRP3

1.08e-04190223f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SYK MYO7A NLRP3

1.08e-041902232d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCellImmune-interstitial_macrophage_(C1Q_positive)|World / Lineage, Cell type, age group and donor

SYK MYO7A NLRP3

1.13e-0419322364d598162a256ac6c9f8280c8a9133661dfbb10f
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SYK MYO7A NLRP3

1.14e-04194223663e7e7fe48157e808b4f1a0ea6ad41944e857a2
ToppCellBAL-Severe-Lymphocyte-T/NK-NK_cell|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CBLB CHST12 RPL6

1.18e-0419622364b23d819efddb25024c86f2e1b5dc4159337ddd
ToppCellBAL-Severe-Lymphocyte-T/NK-NK_cell-NK|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CBLB CHST12 RPL6

1.18e-04196223ba46f80d1497eaf4d71b59504106ba4b84e4ff9f
ToppCellBAL-Severe-Lymphocyte-T/NK-NK_cell-NK-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CBLB CHST12 RPL6

1.18e-04196223eb0b711ca6da7b5e5313791c3c3985358e2a222e
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-NK_CD56bright|ICU-SEP / Disease, condition lineage and cell class

CBLB CHST12 POLA1

1.20e-04197223c187e3fc2160b0165eb039cf09a6e621016068b7
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK MYO7A NLRP3

1.22e-041982235cd5cc67d7bb294582b5e9115cbddfd88aeb5220
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK MYO7A NLRP3

1.22e-04198223311d3ef860d0d883130326fd4601ee9ad89029ff
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SYK MYO7A NLRP3

1.22e-04198223c7dbf24caae5c4ef285845d13055de9e07281bb3
ToppCellTracheal-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SYK MYO7A NLRP3

1.22e-041982230b928a829844f49f4d47e88908af192cb919011f
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK MYO7A NLRP3

1.22e-04198223fa06b60e7ec58754bb622fd439613d63afd2205f
ToppCellMild-Lymphoid-NK-NK|Mild / Condition, Lineage, Cell class and cell subclass

CBLB CHST12 RPL6

1.22e-041982234999cc14642df704819be55594a07eab9c6527aa
ToppCellMild-Lymphoid-NK|Mild / Condition, Lineage, Cell class and cell subclass

CBLB CHST12 RPL6

1.23e-04199223ae8b16e5463c3c41807fef187ee9f501df07e452
ToppCellMild-Lymphoid|Mild / Condition, Lineage, Cell class and cell subclass

CBLB CHST12 RPL6

1.23e-041992235bf1bf2741ab374b1a914fc88ef805903d1941ca
ToppCellcellseq-Immune-Immune_Myeloid-IM|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SYK MYO7A NLRP3

1.23e-04199223b3267d5a7ae0461f5e9e6a3ab6783317a8c42506
ToppCellcellseq-Immune-Immune_Myeloid-IM-IM|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SYK MYO7A NLRP3

1.23e-0419922301dacee8bb392639d475be3cb27ba3eeff1e57f1
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SYK MYO7A NLRP3

1.25e-0420022378d75d381cb2b9a4c9eb7c32a07b014eaee39195
ToppCellBAL-Mild-Lymphocyte-T/NK|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CBLB CHST12 RPL6

1.25e-0420022387c8a4aed9dcfe895d3963708326067e057473c0
ToppCellTracheal-NucSeq-Immune_Myeloid-Monocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SYK MYO7A NLRP3

1.25e-0420022348ce43a27e78b2883e588e1a63fa5352c2deeeb7
ToppCellMild-Lymphoid-T|Mild / Condition, Lineage, Cell class and cell subclass

CBLB CHST12 RPL6

1.25e-0420022394326b61f4eef47e23891becf98103c8145e5f51
ToppCellBAL-Mild-Lymphocyte-T/NK|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

CBLB CHST12 RPL6

1.25e-04200223a6f2e0cf248cc3aa5ccbc812e43227cd8c962915
ToppCellTCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma_Homologous_Type-3|TCGA-Uterus / Sample_Type by Project: Shred V9

SSX3 SSX9P

1.23e-031062222c36d734217598a72c5362b94fc1ae13c7499c1a
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

CCDC168 CCDC178

1.98e-031352223351e8b9e417397c5fa9f856184ff24ce1a27242
ToppCellMild/Remission-B_intermediate-10|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SYK CBLB

2.01e-031362221b3c6edcbe0eb674d2d9c838e83ebe2b93e3eec1
ToppCellCerebellum-Hematopoietic-MICROGLIA|Cerebellum / BrainAtlas - Mouse McCarroll V32

SYK NLRP3

2.10e-0313922275cca1e6c1af289987d5d98455e9c6db81ecdd64
ToppCellLPS-IL1RA-Myeloid-Monocytes,_Macrophages-Neutrophils|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO7A NLRP3

2.10e-03139222505bf5a483fc2ba69377db9850c3b26ab2f416d1
ToppCellCerebellum-Hematopoietic-MICROGLIA-MI1(C1qb)|Cerebellum / BrainAtlas - Mouse McCarroll V32

SYK NLRP3

2.10e-03139222de34e2f51f6fda638357abb662c111a20b83e70b
ToppCellCerebellum-Hematopoietic-MICROGLIA-MI1(C1qb)-MICROGLIA_Microglia.C1qb.Mrc1-Tmem119_(Resident_macrophage)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

SYK NLRP3

2.10e-03139222a077ce50f6d6746d80de35abed5b6dc35b1145b9
ToppCellCerebellum-Hematopoietic-MICROGLIA-MI1(C1qb)-MICROGLIA_Microglia.C1qb.Mrc1-Tmem119_(Resident_macrophage)|Cerebellum / BrainAtlas - Mouse McCarroll V32

SYK NLRP3

2.10e-031392220ae117308bd10d3a7d2688794c69dc5a31cfca5f
ToppCellCerebellum-Hematopoietic-MICROGLIA-MI1(C1qb)-MICROGLIA_Microglia.C1qb.Mrc1-Tmem119_(Resident_macrophage)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

SYK NLRP3

2.10e-03139222fac6a3100a277efa1db250e0c576be1a0c901e6d
ToppCellCerebellum-Hematopoietic|Cerebellum / BrainAtlas - Mouse McCarroll V32

SYK NLRP3

2.10e-031392223913c3828ad4cb5c71380519d0cf5f195e53c51d
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Hematologic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.19e-0314222239ada235a46f2202c093cf2336de224a5957ed1a
ToppCellfacs-Trachea-3m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SYK CCDC178

2.25e-031442228bd042f12186f36bc5aabf6a0232270a448f4b58
ToppCellLPS-IL1RA-Myeloid-Monocytes,_Macrophages-Erythroid|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AK9 NLRP3

2.25e-031442227c471e332f87d60f4dbed01f3e66bf39995218d0
ToppCellfacs-Trachea-3m-Hematologic-myeloid-granulocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SYK NLRP3

2.28e-03145222e381fd90fdaf2ff8c0d2584b6e0a4506418c9593
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC178 PTPRQ

2.28e-0314522296712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SYK NLRP3

2.41e-03149222406a5ccfedbf43543f0346ff7ef3ce1d15c38f29
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SYK NLRP3

2.41e-0314922234a3075af794052763fc7c4135f3031f89da5caa
ToppCellfacs-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l8|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SYK NLRP3

2.41e-031492220f9d2209e8a02371b9f93c0a2fb6f79a4ce48ef1
ToppCellfacs-Trachea-nan-3m-Myeloid-granulocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.41e-031492229c4837aa63e46382ff45a41c72beb5722b3ada19
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SYK NLRP3

2.41e-03149222be698ecce34ddbdf57d08082b71268934675e74e
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SYK NLRP3

2.41e-03149222183c77cc8f23b8406e7241a066cb684470002a3b
ToppCellLymphoid-Lymphoid-B_cells|Lymphoid / shred on cell class and cell subclass (v4)

SYK MACO1

2.44e-031502225ebf6b4b9b029422a4676ba09a6a9225bd25db47
ToppCelldroplet-Mammary_Gland-nan-3m-Myeloid|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.57e-0315422212d3ecb0c4d814a91ac833fcb74db6b9dbc0a321
ToppCelldroplet-Mammary_Gland-nan-3m-Myeloid-macrophage|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.57e-0315422264192a0f78021551886bbaf929916392bce451c0
ToppCellLPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CHST12 AK9

2.57e-0315422216fdafb5c64d2db321554f87129a962d113f1668
ToppCelldroplet-Mammary_Gland-nan-3m-Myeloid-macrophage|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.57e-0315422293ace0a42f3ea94605b13acd79659602b3a31b74
ToppCellGlobus_pallidus-Hematopoietic|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SYK NLRP3

2.64e-0315622267cdaadc3b917f7072adce16c0391472c14a2563
ToppCellfacs-Trachea-18m-Hematologic-myeloid-granulocyte-granulocyte_l8|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SYK NLRP3

2.67e-031572225098675f64342c41c5ca3551b24962d10c83e64d
ToppCellfacs-Lung-Endomucin_-18m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.67e-031572222b60de520edf167f5ca790b478557a778435b3d9
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Myeloid-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.67e-03157222c8f516d3f5622202d3f8514f68614cd86ea3f667
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Myeloid|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.67e-031572224862a11ab8df27d26b4f1c1785e544a2d5b6db6e
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Myeloid-macrophage|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.67e-03157222a0ec1628ce29841889f1d9d4ee9422921af7b0b5
ToppCelldroplet-Heart-nan-18m-Myeloid-mast_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.70e-031582227ebc8b778c97c0faa79e2d80c98b887fa635f901
ToppCelldroplet-Heart-nan-18m-Myeloid|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.70e-0315822281a5a73090804d41429d297ba2462a842f39d380
ToppCelldroplet-Bladder-Unstain-18m-Hematologic-macrophage|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.70e-03158222e5e7b2d609973f1dd4fe7dc62bb69422268ea801
ToppCelldroplet-Bladder-nan-24m-Hematologic-macrophage|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.70e-031582224a9d4706876f6e86fc5d63ad6dc7df1b4a5cfd9e
ToppCelldroplet-Heart-nan-18m-Myeloid-cardiac_mast_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.70e-031582229596b7b0f6f5157a43d67d2e67fb75a2624a6bb9
ToppCellfacs-Lung-EPCAM-18m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.74e-03159222baf843dc44b072504eb1d28de55b1ee67aeec32b
ToppCellfacs-Lung-EPCAM-18m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.74e-031592229eb78202b9a4e8217f00e64d5142ed28c00abd04
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MYO10 NLRP3

2.74e-03159222ded4e3626a62fb6334403b7213b467fb7e8131c3
ToppCelldroplet-Bladder-Unstain-18m-Hematologic|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.74e-03159222a80b4637a74bcc6f213d584aba2c727a983eedb3
ToppCelldroplet-Bladder-Unstain-18m-Hematologic-leukocyte|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.74e-0315922289b5e895e95cdd654edd471bde9b6887939b3503
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MYO10 NLRP3

2.74e-031592222f6c60ddff2208a68146f9786143d9aefd528840
ToppCellfacs-Lung-EPCAM-3m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.77e-03160222b73f07a0088936fbc3656a05710a67f38b4ae551
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l1-4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SYK NLRP3

2.77e-031602226329b0f02f9509086e563c2ed762a8ec693883b5
ToppCellfacs-Lung-EPCAM-3m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.77e-03160222b88876a58fea2066468e74dcc439c8561130a910
ToppCellLPS-antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SYK NLRP3

2.77e-031602225d8d97c3da5837ba5fe743d2f8438f5cb7cea64b
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.80e-03161222e227f7b711475624cf80e77f235b1783d88d57b4
ToppCellfacs-Large_Intestine-Proximal-24m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHST12 RPL6

2.80e-031612229edcab51da01a84cfe6166ed4c1f951a4ceeac55
ToppCelldroplet-Mammary_Gland-nan-21m-Myeloid|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.80e-031612223db97af49520dc8cbafb4454d8afd9d588160e89
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.80e-031612228280a029026c272cae9649b27575831b0dd4e242
ToppCellfacs-Large_Intestine-Proximal-24m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHST12 RPL6

2.80e-03161222cb4921da94b3355d5234b389aa3ec15939607cd5
ToppCelldroplet-Mammary_Gland-nan-21m-Myeloid-macrophage|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.80e-03161222f1d258c81bcf0f3c52bd20aa58faa9a5fd888168
ToppCelldroplet-Mammary_Gland-nan-21m-Myeloid-macrophage|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.80e-03161222787f91f906756ef570c0d02936c3cdfafb3f7454
ToppCelldroplet-Mammary_Gland-nan-18m-Myeloid|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.84e-031622228e0bcc23c3086fc4b0c9dbeec13a7edaf6b83750
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CCDC178 PTPRQ

2.84e-03162222bf886e22ff2a20353499004b53f25fb9e6574896
ToppCelldroplet-Mammary_Gland-nan-18m-Myeloid-macrophage|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.84e-03162222736fdcbd0f7d50fc297f13d36ab4c0dc82ad509c
ToppCell367C-Lymphocytic-ILC-ILC-1|367C / Donor, Lineage, Cell class and subclass (all cells)

CBLB MYO7A

2.84e-0316222274cd0de957fdbe527656befd61f67d6814ce9e98
ToppCelldroplet-Marrow-BM-30m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO10 NLRP3

2.84e-0316222275df7ff779a3b9159ba97d852da1f8df650b9ce5
ToppCellfacs-Lung-18m-Hematologic-myeloid-neutrophil-neutrophil|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SYK NLRP3

2.84e-031622224e7e565091bce227d794a36af2e5dfc4a791efad
ToppCelldroplet-Bladder-nan-3m-Hematologic-macrophage|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.84e-031622220cee9ef405765f3f82d0cd7b8adc88f6e9fdbb5c
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Myeloid-macrophage|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.84e-03162222db1e09324e9fdd5e571600cff4f2b1c0cb3c179d
ToppCellfacs-Lung-18m-Hematologic-myeloid-neutrophil|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SYK NLRP3

2.84e-03162222ad974426039f4952c59d27167eac24dc6ce63f5e
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Myeloid-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.84e-031622229734943c8b7c04e568792253b7352672a3a5cc58
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B2|367C / Donor, Lineage, Cell class and subclass (all cells)

CHST12 AK9

2.84e-0316222259c0dcb5b51c1803660aeec51b60deceeeaeea66
ToppCelldroplet-Mammary_Gland-nan-18m-Myeloid-macrophage|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.84e-0316222259147406c28b7cdf43a1815f99c15c2bd6ae8fa3
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Myeloid|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.84e-0316222248d7bee271f74b5d06c03c6ae06a662d765a6de3
ToppCelldroplet-Bladder-nan-3m-Hematologic-leukocyte|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.87e-031632222f32a9ab0230fdca98ffa7fd59397301d50e4f30
ToppCelldroplet-Pancreas-Endocrine-18m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.87e-03163222aaff80d254131d1f1230bb12b6f43bc061ab5ab3
ToppCelldroplet-Pancreas-Endocrine-18m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.87e-031632228b0f8a2d5b38f3bbff265211a7607acc85fa38b0
ToppCelldroplet-Bladder-nan-3m-Hematologic|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK NLRP3

2.87e-031632226c2967dee563295febe2adabf503d095cb911ccf
DiseaseAutoinflammatory disorder

POLA1 NLRP3

2.31e-0435192C3860213
DiseaseMultiple Sclerosis

CBLB NLRP3

3.83e-0445192C0026769
DiseaseMultiple Sclerosis, Acute Fulminating

CBLB NLRP3

3.83e-0445192C0751324
Diseaseoropharynx cancer

CBLB MACO1

4.00e-0446192EFO_1001931
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

MYO7A PTPRQ

4.92e-0451192cv:CN043650
Diseasefibrinogen measurement, factor VII measurement

RPL6 NLRP3

6.36e-0458192EFO_0004619, EFO_0004623
DiseaseNonsyndromic genetic hearing loss

MYO7A PTPRQ

1.09e-0376192cv:C5680182
DiseaseCholestasis

PAN2 RELA

2.26e-03110192C0008370
DiseasePapillary Renal Cell Carcinoma

SETD2 RELA

3.04e-03128192C1306837
DiseaseRenal Cell Carcinoma

SETD2 RELA

3.04e-03128192C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

SETD2 RELA

3.04e-03128192C1266043
DiseaseChromophobe Renal Cell Carcinoma

SETD2 RELA

3.04e-03128192C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

SETD2 RELA

3.04e-03128192C1266044

Protein segments in the cluster

PeptideGeneStartEntry
MVSKKYRKVTIKYSK

PAN2

486

Q504Q3
KKGYYQMKKVVKTVA

SYK

386

P43405
YFKIYIDSLMKKSKR

CBLB

106

Q13191
KYESEIKYLTIMKLK

CCDC178

476

Q5BJE1
KSYVSYKMRLRKQKE

MACO1

171

Q8N5G2
KLMKAYISMIVKKRY

MYO10

2031

Q9HD67
IATKYKIMKFKSKPV

POLA1

421

P09884
FLITGLKKYTKYKMR

PTPRQ

666

Q9UMZ3
LKKYTKYKMRVAAST

PTPRQ

671

Q9UMZ3
IKYVVDTGMVKAKKY

DHX33

366

Q9H6R0
KSVLSVKYVIMKVKK

CCDC168

1081

Q8NDH2
RISICKMKKDYRKKY

NLRP3

126

Q96P20
SEYTRKKYKKKMEQF

AK9

1851

Q5TCS8
KVSEKIVYVYMKRKY

SSX3

41

Q99909
MKVKLKKYTKFLFVR

CHST12

231

Q9NRB3
SQLKKMVSKYKYRDL

TSG101

6

Q99816
KAMYKRKYSAAKSKV

RPL6

66

Q02878
KASEKIIYVYMKRKY

SSX5

41

O60225
KSLEKISYVYMKRKY

SSX7

41

Q7RTT5
KSSEKIIYVYMKRKY

SSX9P

41

Q7RTT3
VKHKTKEYIKKYMQK

SETD2

2536

Q9BYW2
KRKRTYETFKSIMKK

RELA

301

Q04206
MTKIYETLGKKTYKR

MYO7A

1071

Q13402