Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP17L7 USP17L6P USP17L5 USP6 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

6.27e-261144216GO:0004843
GeneOntologyMolecularFunctiondeubiquitinase activity

USP17L7 USP17L6P USP17L5 USP6 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

2.61e-251244216GO:0101005
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP17L7 USP17L6P USP17L5 USP6 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

1.40e-241374216GO:0019783
GeneOntologyMolecularFunctioncysteine-type peptidase activity

USP17L7 USP17L6P USP17L5 USP6 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

3.79e-221924216GO:0008234
GeneOntologyMolecularFunctionpeptidase activity

USP17L7 USP17L6P USP17L5 USP6 USP17L21 PLAU USP17L10 USP17L19 CELA2B USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 PROC USP17L24 USP17L13 CELA2A USP17L18

3.97e-196544220GO:0008233
GeneOntologyMolecularFunctionserine-type endopeptidase activity

PLAU CELA2B PROC CELA2A

6.70e-04190424GO:0004252
GeneOntologyMolecularFunctionserine-type peptidase activity

PLAU CELA2B PROC CELA2A

9.22e-04207424GO:0008236
GeneOntologyMolecularFunctionprotein-hormone receptor activity

LHCGR TSHR

9.71e-0422422GO:0016500
GeneOntologyMolecularFunctionserine hydrolase activity

PLAU CELA2B PROC CELA2A

1.01e-03212424GO:0017171
GeneOntologyMolecularFunctionhyaluronic acid binding

USP17L6P USP17L24

1.69e-0329422GO:0005540
GeneOntologyMolecularFunctionendopeptidase activity

USP6 PLAU CELA2B PROC CELA2A

2.00e-03430425GO:0004175
GeneOntologyBiologicalProcessprotein deubiquitination

USP17L7 USP17L6P USP17L5 USP6 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

4.43e-251254416GO:0016579
GeneOntologyBiologicalProcessprotein modification by small protein removal

USP17L7 USP17L6P USP17L5 USP6 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

4.77e-241444416GO:0070646
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

USP17L7 USP17L6P USP17L5 USP6 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

1.09e-1010094416GO:0070647
GeneOntologyBiologicalProcesspost-translational protein modification

USP17L7 USP17L6P USP17L5 USP6 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

2.74e-1010744416GO:0043687
GeneOntologyBiologicalProcessprotein deubiquitination involved in ubiquitin-dependent protein catabolic process

USP17L6P USP17L24

1.24e-048442GO:0071947
GeneOntologyCellularComponentendoplasmic reticulum membrane

USP17L7 JPH1 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

2.87e-0812934415GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

USP17L7 JPH1 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

3.05e-0812994415GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

USP17L7 JPH1 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

4.05e-0813274415GO:0042175
GeneOntologyCellularComponentkeratohyalin granule

CELA2B CELA2A

4.31e-055442GO:0036457
MousePhenoincreased lymphocyte cell number

LHCGR USP6 PLAU ZFYVE16 USP17L15 ESR2 USP17L13 IL9R

3.50e-05797248MP:0005013
MousePhenoincreased trophectoderm apoptosis

USP17L15 USP17L13

7.86e-058242MP:0012119
MousePhenoabnormal lymphocyte morphology

LHCGR USP6 PLAU TSHR LY75 ZFYVE16 USP17L15 ESR2 USP17L13 IL9R

8.48e-0514832410MP:0002619
MousePhenoabnormal parasympathetic nervous system physiology

CELA2B CELA2A

1.54e-0411242MP:0006277
DomainHABP4_PAI-RBP1

USP17L7 USP17L5 USP17L21 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18

2.70e-30164012PF04774
DomainHABP4_PAIRBP1-bd

USP17L7 USP17L5 USP17L21 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18

2.70e-30164012IPR006861
DomainUSP_CS

USP17L7 USP17L5 USP6 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18

2.34e-25664014IPR018200
DomainUSP_1

USP17L7 USP17L5 USP6 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18

5.81e-25704014PS00972
DomainUCH

USP17L7 USP17L5 USP6 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18

7.23e-25714014PF00443
DomainUSP_2

USP17L7 USP17L5 USP6 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18

7.23e-25714014PS00973
DomainUSP_3

USP17L7 USP17L5 USP6 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18

8.96e-25724014PS50235
DomainUSP_dom

USP17L7 USP17L5 USP6 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18

8.96e-25724014IPR028889
DomainPeptidase_C19_UCH

USP17L7 USP17L5 USP6 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18

8.96e-25724014IPR001394
DomainTRYPSIN_SER

PLAU CELA2B PROC CELA2A

4.04e-0590404IPR033116
DomainGphrmn_rcpt_fam

LHCGR TSHR

6.67e-056402IPR002131
DomainTRYPSIN_HIS

PLAU CELA2B PROC CELA2A

6.84e-05103404IPR018114
DomainTRYPSIN_SER

PLAU CELA2B PROC CELA2A

7.65e-05106404PS00135
DomainTRYPSIN_HIS

PLAU CELA2B PROC CELA2A

7.94e-05107404PS00134
DomainPeptidase_S1A

PLAU CELA2B PROC CELA2A

9.81e-05113404IPR001314
DomainTRYPSIN_DOM

PLAU CELA2B PROC CELA2A

1.05e-04115404PS50240
DomainTryp_SPc

PLAU CELA2B PROC CELA2A

1.12e-04117404SM00020
DomainTrypsin

PLAU CELA2B PROC CELA2A

1.28e-04121404PF00089
DomainTrypsin_dom

PLAU CELA2B PROC CELA2A

1.28e-04121404IPR001254
DomainPeptidase_S1_PA

PLAU CELA2B PROC CELA2A

1.36e-04123404IPR009003
DomainLRR_5

LHCGR TSHR

1.99e-0410402PF13306
DomainLRR_5

LHCGR TSHR

1.99e-0410402IPR026906
DomainKringle-like

PLAU LY75

2.13e-0332402IPR013806
DomainUBA-like

LATS2 TNRC6A

8.29e-0364402IPR009060
PathwayREACTOME_RAS_PROCESSING

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

6.97e-27453714MM15671
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 PSMA4 USP17L13 USP17L18

3.94e-191913715MM15289
PathwayREACTOME_DEUBIQUITINATION

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 PSMA4 USP17L13 USP17L18

4.75e-172623715MM15286
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 PSMA4 USP17L24 USP17L13 USP17L18

1.59e-162213714M27578
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 PSMA4 USP17L13 USP17L18

8.59e-163183715MM15278
PathwayREACTOME_DEUBIQUITINATION

USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 PSMA4 USP17L24 USP17L13 USP17L18

1.09e-142993714M27574
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 SPON1 PSMA4 PROC USP17L13 USP17L18

1.65e-0813893717MM15307
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 SPON1 PSMA4 PROC USP17L24 USP17L13 USP17L18

2.89e-0714753716M19806
PathwayPID_ARF6_PATHWAY

LHCGR USP6 TSHR

1.03e-0435373M86
PathwayBIOCARTA_PEPI_PATHWAY

CELA2B CELA2A

1.40e-047372MM1589
PathwayBIOCARTA_PEPI_PATHWAY

CELA2B CELA2A

1.86e-048372M22084
PathwayREACTOME_HORMONE_LIGAND_BINDING_RECEPTORS

LHCGR TSHR

4.35e-0412372M13070
PathwayREACTOME_HORMONE_LIGAND_BINDING_RECEPTORS

LHCGR TSHR

6.89e-0415372MM14972
Pubmed

DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

3.07e-3721441411468161
Pubmed

The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

3.07e-372144148756639
Pubmed

DUB-1, a deubiquitinating enzyme with growth-suppressing activity.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

3.07e-372144148622927
Pubmed

DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

3.07e-3721441414583620
Pubmed

Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

3.07e-3721441412447969
Pubmed

DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

3.07e-3721441418980247
Pubmed

JAK2 is required for induction of the murine DUB-1 gene.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

8.43e-372244149154835
Pubmed

Cdc25A and Dub3 in a high-stakes balancing act.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

2.34e-3633441520228807
Pubmed

Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

4.19e-3634441520715989
Pubmed

Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

4.19e-363444159806828
Pubmed

The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

4.19e-3634441520368735
Pubmed

The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

4.19e-3634441515780755
Pubmed

The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

4.19e-3634441520403174
Pubmed

USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

4.19e-3634441519188362
Pubmed

Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

4.19e-3634441517109758
Pubmed

Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

4.19e-3634441511941478
Pubmed

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

4.19e-3634441520388806
Pubmed

DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

4.19e-3634441514699124
Pubmed

The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

4.19e-3634441510936051
Pubmed

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

4.19e-3634441521448158
Pubmed

DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

5.16e-362444148995226
Pubmed

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

7.32e-3635441521239494
Pubmed

Cytokine-regulated protein degradation by the ubiquitination system.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

7.32e-3635441516611142
Pubmed

Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

1.17e-3525441421115691
Pubmed

The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

1.25e-3536441520147298
Pubmed

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

2.11e-3537441520228808
Pubmed

Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

2.54e-3526441435816173
Pubmed

Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

2.03e-3429441432527007
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

2.42e-3050441431806660
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 LY75 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

2.39e-15674441537196079
Pubmed

A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.

USP17L21 USP17L19 USP17L12 USP17L17 USP17L20 USP17L11 USP17L18

1.58e-1011944728625976
Pubmed

High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.

USP17L7 USP17L6P USP17L15

2.25e-071044324207026
Pubmed

Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.

USP17L7 USP17L6P USP17L15

4.12e-071244324695638
Pubmed

ES cell neural differentiation reveals a substantial number of novel ESTs.

USP17L7 USP17L6P USP17L15

6.81e-071444311793228
Pubmed

Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding.

LHCGR TSHR

1.56e-0624421651314
Pubmed

An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.

LHCGR TSHR

1.56e-06244218162522
Pubmed

Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing.

LHCGR TSHR

1.56e-0624422293030
Pubmed

A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor.

LHCGR TSHR

1.56e-06244211312274
Pubmed

Delay of postnatal maturation sensitizes the mouse prostate to testosterone-induced pronounced hyperplasia: protective role of estrogen receptor-beta.

LHCGR ESR2

1.56e-06244217640960
Pubmed

Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.

CELA2B CELA2A

1.56e-0624423646943
Pubmed

Elastase-2, a Tissue Alternative Pathway for Angiotensin II Generation, Plays a Role in Circulatory Sympathovagal Balance in Mice.

CELA2B CELA2A

1.56e-06244228386233
Pubmed

Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans.

CELA2B CELA2A

1.56e-06244216327289
Pubmed

Insights into differential modulation of receptor function by hinge region using novel agonistic lutropin receptor and inverse agonistic thyrotropin receptor antibodies.

LHCGR TSHR

1.56e-06244222309849
Pubmed

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.

USP17L7 USP17L6P USP17L15

1.80e-061944328067227
Pubmed

Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage.

LHCGR TSHR ESR2

2.12e-062044320716560
Pubmed

Human and mouse proteases: a comparative genomic approach.

USP17L7 USP17L6P USP6 USP17L15

3.45e-068144412838346
Pubmed

Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer.

LHCGR ESR2

4.69e-06344222245602
Pubmed

Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.

CELA2B CELA2A

4.69e-0634423427074
Pubmed

Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.

LHCGR TSHR

4.69e-0634428747461
Pubmed

The Tre2 oncoprotein, implicated in Ewing's sarcoma, interacts with two components of the cytoskeleton.

ANKRD44 USP6

4.69e-06344216555005
Pubmed

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors.

LHCGR TSHR

4.69e-06344211847099
Pubmed

Further studies of genetic susceptibility to Graves' disease in a Russian population.

TSHR ESR2

4.69e-06344211887032
Pubmed

Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity.

LHCGR TSHR

4.69e-06344215889138
Pubmed

Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.

USP17L15 USP17L13

9.37e-06444222984479
Pubmed

Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.

CELA2B CELA2A

1.56e-05544220179351
Pubmed

Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris.

PLAU PROC

1.56e-0554427548163
Pubmed

The DNA-binding activity of transcription factor PTF1 parallels the synthesis of pancreas-specific mRNAs during mouse development.

CELA2B CELA2A

3.27e-0574422294404
Pubmed

Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes.

CELA2B CELA2A

3.27e-0574423641189
Pubmed

Purification and characterization of plasma protein C inhibitor.

PLAU PROC

3.27e-0574422551064
Pubmed

Effect of polymorphisms in selected genes involved in pituitary-testicular function on reproductive hormones and phenotype in aging men.

LHCGR ESR2

5.60e-05944220173016
Pubmed

Genetic variation in sex hormone genes influences heel ultrasound parameters in middle-aged and elderly men: results from the European Male Aging Study (EMAS).

LHCGR ESR2

5.60e-05944218767927
Pubmed

Evidence for similar expression of protein C inhibitor and the urokinase-type plasminogen activator system during mouse testis development.

PLAU PROC

8.54e-051144214645112
Pubmed

Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.

PLAU ESR2 PROC IL9R

9.10e-0518644420452482
Pubmed

A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).

PLAU ESR2 PROC IL9R

9.10e-0518644420673868
Pubmed

Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development.

CELA2B CELA2A

1.63e-041544224793170
Pubmed

Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells.

CELA2B CELA2A

1.86e-041644219635472
Pubmed

The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas.

CELA2B CELA2A

1.86e-04164429851981
Pubmed

Early embryonic expression of murine coagulation system components.

PLAU PROC

8.55e-043444211154109
Pubmed

The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.

CELA2B CELA2A

9.59e-043644225063451
Pubmed

Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).

LHCGR ESR2

1.07e-033844219574343
InteractionFLT3 interactions

USP17L21 USP17L19 USP17L12 USP17L17 USP17L20 USP17L11 USP17L18

2.72e-06318407int:FLT3
Cytoband4p16.1

USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

6.50e-297944144p16.1
CytobandEnsembl 112 genes in cytogenetic band chr4p16

USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

2.55e-222224414chr4p16
Cytoband1p36.21

CELA2B CELA2A

1.69e-03634421p36.21
GeneFamilyGlycoprotein hormone receptors

LHCGR TSHR

3.85e-063212199
CoexpressionMADAN_DPPA4_TARGETS

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

2.70e-25864214MM1312
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

1.39e-231124214MM1095
CoexpressionGERY_CEBP_TARGETS

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

2.55e-211604214MM1155
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

7.58e-136474214MM981
CoexpressionBRUINS_UVC_RESPONSE_LATE

USP17L7 USP17L6P USP17L5 USP17L21 MFAP4 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 PSMA4 USP17L13 USP17L18

1.78e-1111984216MM1062
CoexpressionMARSON_BOUND_BY_FOXP3_STIMULATED

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 IL9R USP17L18

4.76e-1110724215MM1031
CoexpressionGRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18

3.44e-0912264214MM979
CoexpressionBERGER_MBD2_TARGETS

CELA2B CELA2A

1.37e-0411422MM905
ToppCellP07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LHCGR MFAP4 LIMCH1 SPON1

9.51e-06161374b19f82dd98a3064581793711bb70373f18abecd9
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MFAP4 LIMCH1 TENM2 SPON1

1.98e-0519437435f132cc38ac133be01834ed0946188aa0757eb4
ToppCellPCW_10-12|World / Celltypes from embryonic and fetal-stage human lung

USP6 MFAP4 LIMCH1 SPON1

2.10e-0519737447fd8b0d596c5db1a722473c8efbb17a6bbe7538
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Suprabasal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

JPH1 TSHR SPOCK3 ESR2

2.23e-05200374924eacea513dde8e3bd805a335bc4285647b800d
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast-FB-2|PND01-03-samps / Age Group, Lineage, Cell class and subclass

MFAP4 LIMCH1 SPON1

1.52e-041253736cd741dd1c7ee6b16437cca7c15c99b5c95603fc
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-3|TCGA-Brain / Sample_Type by Project: Shred V9

TSHR CELA2B CELA2A

1.91e-04135373b128596653a5e3b64ed7f657bbfeda35438e2e48
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

CELA2B ZFYVE16 CELA2A

2.55e-04149373768877bade04ca0321593b8470b5011ad8270431
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1|E16.5-samps / Age Group, Lineage, Cell class and subclass

MFAP4 LIMCH1 SPON1

3.31e-04163373f1ec2625b52664308968b01d8e0275e1e0751480
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|E18.5-samps / Age Group, Lineage, Cell class and subclass

MFAP4 LIMCH1 SPON1

3.37e-04164373519ab4fe885dfe4c50846f346a062acc2cb44299
ToppCell356C-Myeloid-Monocyte-CD16+_Monocyte|356C / Donor, Lineage, Cell class and subclass (all cells)

ZNF584 KYNU PROC

3.43e-0416537335a6de30438de364ccca948fc932da541a69ef89
ToppCellBronchial_Brush-Immune-B_cells|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

TSHR IGLV3-21 IL9R

3.68e-04169373dc388f660f69e37e517bf3243daf071ab138ee6e
ToppCellE17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MFAP4 LIMCH1 SPON1

3.75e-041703737fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MFAP4 LIMCH1 SPON1

3.75e-04170373e20568c8f3f17d94de78229617eb2f7e4c5af2bc
ToppCellILEUM-non-inflamed-(3)_MNP-(3)_mature_DC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

LIMCH1 LY75 SPON1

3.81e-04171373341f9f79c1ed654ab347e25dc4936f89ffdf9617
ToppCellfacs-Heart-RV-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LY75 KYNU IL9R

3.88e-041723732dcc9d67d6ecc35940eabbc8ed528f5f884f6976
ToppCellfacs-Heart-RV-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LY75 KYNU IL9R

3.88e-0417237364d2edbd8e2640b76225597883b1a524e6b1dd3b
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

USP6 MFAP4 DLX4

3.88e-041723732b0333c21b7472194a7b9feb3de121da3340fc5b
ToppCellfacs-Heart-RV-18m-Lymphocytic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LY75 KYNU IL9R

3.88e-04172373d061ea21bee179df5a525842e9a48621a8e1461b
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic-migDC|lymph-node_spleen / Manually curated celltypes from each tissue

PLAU LIMCH1 TENM2

3.88e-041723731b24bed3cd8e3fa463c5e7cefdf9e99e639e2f84
ToppCellP28-Mesenchymal-developing_mesenchymal_cell-mesenchymal_mature_unknown_2|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MFAP4 LIMCH1 SPON1

3.94e-041733738565966f4faf5f31190f65123a1bd221782db814
ToppCellP15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MFAP4 LIMCH1 SPON1

4.01e-041743733c47d069bd836599a8d40eae485c23d4d3487517
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 SPON1 IL9R

4.08e-0417537359249c9e83952d7277010e7be3c779e26399eb5d
ToppCellP03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MFAP4 LIMCH1 SPON1

4.08e-04175373282f09bbdfa70d93b3f66591dcfb84c5ee0268c7
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD44 LATS2 ZFYVE16

4.08e-04175373c1c722db42da9b8a2a46e516ddb83d9be5e2e504
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 SPON1 IL9R

4.08e-04175373b35cc1357495f2a03a6500f807c6e6f8c877734d
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MFAP4 LIMCH1 SPON1

4.15e-04176373cb8fd56a4f935cdda19d7ab43382cdda7c307667
ToppCellLPS-IL1RA+antiTNF|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MFAP4 LIMCH1 SPON1

4.22e-04177373b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell390C-Fibroblasts-Fibroblast-G|390C / Donor, Lineage, Cell class and subclass (all cells)

MFAP4 LIMCH1 SPON1

4.43e-04180373137fc14859c89e1ecd98bee388bb58c04b835847
ToppCelldroplet-Liver-LIVER-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLX4 SPOCK3 IL9R

4.43e-0418037347e345359064dc8ceec982b062e47802e728b43f
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MFAP4 LIMCH1 SPON1

4.43e-0418037308ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCelldroplet-Liver-LIVER-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLX4 SPOCK3 IL9R

4.43e-041803733d95232b5785c705f41e01e3ffe0fa8dce1ff0a7
ToppCell356C-Myeloid-Macrophage-SPP1+_Macrophage_2|356C / Donor, Lineage, Cell class and subclass (all cells)

ZFYVE16 KYNU PROC

4.43e-04180373b94618c1c2592ecf7da3535294aee9243755247a
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MFAP4 LIMCH1 SPON1

4.43e-041803739b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCellMatrixFB-Fibroblast-A|MatrixFB / shred on cell class and cell subclass (v4)

MFAP4 LIMCH1 SPON1

4.43e-04180373adc64ad6033af705dd7b9163a83e20ef5c59f6eb
ToppCell390C-Fibroblasts-Fibroblast-G-|390C / Donor, Lineage, Cell class and subclass (all cells)

MFAP4 LIMCH1 SPON1

4.43e-04180373cd6790de050151fedfa2c5ea6ad58b72665414b2
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MFAP4 LIMCH1 SPON1

4.50e-041813739e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCellP28-Mesenchymal-mesenchymal_fibroblast|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MFAP4 LIMCH1 SPON1

4.50e-04181373091e7975badd1ffa463a8ec87908be20781ecfd6
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LHCGR MFAP4 SPON1

4.50e-04181373eea943fdcbef0bbaa8578f3296923e874893b405
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LHCGR MFAP4 SPON1

4.50e-041813739c157de9d3403e092c907599f2a2c16db5b21131
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast|E18.5-samps / Age Group, Lineage, Cell class and subclass

MFAP4 LIMCH1 SPON1

4.57e-04182373ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCellfacs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

4.57e-04182373dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCellP28-Mesenchymal|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MFAP4 LIMCH1 SPON1

4.57e-0418237369f9d44694fe4f55a971ae0ac5dc3e7448ee78f3
ToppCellfacs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

4.57e-04182373c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCellP28-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MFAP4 LIMCH1 SPON1

4.57e-0418237319c5e3a9d9b3728303b682102e276adfe93aa759
ToppCell3'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-Treg|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TSHR LY75 RCBTB1

4.65e-04183373450c30d2e389fcb17825394c27f9ccc4f33022e3
ToppCellCOVID-19-APC-like-Dendritic_cells|COVID-19 / group, cell type (main and fine annotations)

ANKRD44 LY75 KYNU

4.65e-04183373703364836b42aa6ac6c68b42b700ac23c4a1afc7
ToppCellCOVID-19-APC-like|COVID-19 / group, cell type (main and fine annotations)

ANKRD44 LY75 KYNU

4.65e-04183373b8f5afaf9ff1b2b1bc60be58654d1b23859dafa9
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LHCGR MFAP4 SPON1

4.65e-04183373bc7dd6a40ec9c773d005c1a46f305d40cdd0a326
ToppCelldroplet-Lung-nan-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

4.72e-0418437389ac32e374a4379e4a6c6ea7603b1378b77c147f
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MFAP4 LIMCH1 SPON1

4.72e-04184373924400f47e6b2cdf7b0d538df75857935cf0209b
ToppCelldroplet-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

4.72e-041843734df6027fa635996c1eddb920f88a5265772df1cd
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_2|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TSHR SPOCK3 PROC

4.72e-041843730a26bcc6610f756939e32a4d6dfeebcbf3a1db86
ToppCellP15-Mesenchymal-mesenchymal_fibroblast|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MFAP4 LIMCH1 SPON1

4.79e-0418537346460e74cc613df9043f5404e7342aa13cc34873
ToppCelldroplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MFAP4 LIMCH1 SPON1

4.79e-04185373355b03c7ea438681e11a2b872c798c9ea26e1486
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_2|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TSHR SPOCK3 PROC

4.79e-04185373fec16a5e527fdef32d25957451b6e8ee9796cafd
ToppCellP03|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MFAP4 LIMCH1 SPON1

4.79e-04185373a07dbe1f76e40734a28826423a5cc64b8e56af5e
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

4.87e-04186373ca5e9c6531cb5d199e27509bfab1d62e3937177e
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

4.87e-041863731ed71b229f40a680071b14f5a7a19706e0fd14b1
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MFAP4 PLAU LIMCH1

4.87e-04186373360c3e9e5c3a943e68e6939b4a47821bfc75b553
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MFAP4 LIMCH1 SPON1

4.87e-0418637388e6246172d816806a498a5c1f38e699f2f5d7c2
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MFAP4 LIMCH1 SPON1

4.95e-0418737313731298bc562ec29582f5da1b4c97261284f6f1
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

4.95e-04187373976b74d081b7fba8620768613cc26f9262cd7b16
ToppCellP15-Mesenchymal|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MFAP4 LIMCH1 SPON1

5.02e-04188373f1ba0b661621a65c91432e62ba73531bdf18e7c1
ToppCellFibroblast-A|World / shred on cell class and cell subclass (v4)

MFAP4 LIMCH1 SPON1

5.02e-041883736740bed5fb8f45b6eea17041894b804214c2a4ae
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MFAP4 LIMCH1 SPON1

5.10e-0418937340cbd679dc0548bf5207e1b033c0597886ad6fe1
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

5.10e-0418937332e6d6285b258831b965281224ff2aaeecdcb5f5
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

5.10e-04189373324c81285c51f4f8bb1aef428b18fe2c549c2c11
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MFAP4 LIMCH1 SPON1

5.10e-04189373a153b83314cf52808f685296cff8c95af3f4983d
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MFAP4 LIMCH1 SPON1

5.10e-04189373e9d5e858e320c6e9913c1ea6a54967d21eda605f
ToppCelldroplet-Lung-immune-endo-depleted|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

5.10e-04189373c3fb363bb0156ffb3367c200f548faebda64ab4a
ToppCellwk_15-18-Mesenchymal-Fibroblast-Airway_fibro|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

MFAP4 TENM2 SPON1

5.10e-041893734f9608b84d135268a17455661870c46ae8554a24
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MFAP4 LIMCH1 SPON1

5.10e-041893732a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCellfacs-Lung-18m-Mesenchymal|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MFAP4 LIMCH1 SPON1

5.10e-04189373bdf8db938aa0863c4fed6fa99dcffd63c8c20c31
ToppCelldroplet-Lung-immune-endo-depleted-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

5.10e-041893732a2953f6b1b7d070d739dcaf7285fce6e097d9e4
ToppCelldroplet-Lung-3m|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MFAP4 LIMCH1 SPON1

5.10e-041893735a636e952da9b1fd26aa17f7b129054f2da322b5
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

5.10e-04189373385ef7bbd76c8047aeecf6542377d4213b5da5db
ToppCelldroplet-Lung-18m-Mesenchymal-fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MFAP4 LIMCH1 SPON1

5.10e-04189373e76dc36a01d8ad7590b3acc4c46abfcb76857448
ToppCellPND07-28-samps-Mesenchymal-Matrix_fibroblast|PND07-28-samps / Age Group, Lineage, Cell class and subclass

MFAP4 LIMCH1 SPON1

5.10e-04189373dc5164591dea45b420798b94dda211be03daa70c
ToppCellnormal_Lymph_Node-Myeloid_cells-Activated_DCs|normal_Lymph_Node / Location, Cell class and cell subclass

LIMCH1 LY75 TENM2

5.18e-0419037315978ddd37b521343f88b62dad1643077fc22b2b
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

5.18e-0419037300fd993675faf53adf985b9316a18c8a33242029
ToppCelldroplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 PLAU SPON1

5.18e-041903738cb950effc449ae59a915132ecc079be54d1acfe
ToppCellPND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3|PND07-28-samps / Age Group, Lineage, Cell class and subclass

MFAP4 LIMCH1 SPON1

5.18e-041903731196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCelldroplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 PLAU SPON1

5.18e-0419037317a73a658fb30a4322b31e38db7b240023738f29
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

5.18e-041903739cd147a174017ebda23cc47b6d4552d898acd092
ToppCelldroplet-Lung-18m-Mesenchymal|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MFAP4 LIMCH1 SPON1

5.18e-041903730b7200897b2c389632c9b1ee37e272b811555dbc
ToppCell(2)_Fibroblasts-(21)_Fibro-2|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis

DLX4 LIMCH1 SPON1

5.18e-04190373d2afa08ad868acc6fce308ec21b0bf93591d4010
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

5.18e-041903738cda09d761c6b504a744959d587c183f94f1beeb
ToppCelldroplet-Pancreas-Exocrine-24m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 PLAU SPON1

5.18e-041903735dfbd064ab1f8a0b18b5975c47f8e79697f3db15
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MFAP4 LIMCH1 SPON1

5.26e-04191373509230f50568e5a8ecf08edc4d58f9e2aa96efe9
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MFAP4 LIMCH1 SPON1

5.26e-0419137344a9a6768084dafc641ad455b65862bfd4cc0cb9
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic|lymph-node_spleen / Manually curated celltypes from each tissue

PLAU LIMCH1 PROC

5.26e-04191373c3ff4342e0eea1e1f071b1fbca14a6dd4df0c696
ToppCellControl-Myeloid-tDC|Control / Disease, Lineage and Cell Type

PLAU PSMA4 PROC

5.26e-041913735c1d6a52181eba01e9177d00fe941dda85ef7eb2
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MFAP4 LIMCH1 SPON1

5.26e-041913735c4e4e9de14edfae072a2a2882220a31bebf51b2
ToppCelldroplet-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MFAP4 LIMCH1 SPON1

5.26e-0419137336467322096bc766cd777dae3bfb4e65511e492c
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MFAP4 LIMCH1 SPON1

5.26e-04191373b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MFAP4 LIMCH1 SPON1

5.26e-04191373a261f0738d974784bbdd60f23092bfbcca464459
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MFAP4 LIMCH1 SPON1

5.26e-04191373d04e6292fef189b8d8ed0f4b0c310b2b250fd30e
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MFAP4 LIMCH1 SPON1

5.26e-04191373f00d6824bd138b192a996e9f7de57b235bb24c18
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal|E16.5-samps / Age Group, Lineage, Cell class and subclass

MFAP4 LIMCH1 SPON1

5.26e-041913733379d145d34f89150f7b06d1340022cfc6b4a6ce
ToppCellP07-Mesenchymal-mesenchymal_fibroblast|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MFAP4 LIMCH1 SPON1

5.26e-04191373a05e9a7eb137d804570dd7d8905975d735738767
ComputationalSerine proteases.

PLAU CELA2B PROC CELA2A

8.47e-0739214MODULE_109
DrugTs-I

LHCGR TSHR LATS2 ESR2

3.19e-0675314CID000445278
DrugA-26

LHCGR TSHR LATS2

5.15e-0625313CID000037120
DrugOrg 41841

LHCGR TSHR

1.79e-055312ctd:C510603
Drugthieno[2,3-d]pyrimidine

LHCGR TSHR

2.68e-056312CID012225304
Drugpotassium iodide

TSHR LATS2 ESR2

3.56e-0547313CID000004875
DrugCG-R

LHCGR TSHR LATS2

4.04e-0549313CID011987895
DrugDiethylstilbestrol

LHCGR MFAP4 DLX4 TSHR RCBTB1 KYNU SPON1 ESR2 PSMA4

4.15e-051305319ctd:D004054
Drug1XS7

TSHR LATS2 LY75

9.43e-0565313CID000449218
Drug6-amino-1-naphthalenesulfonamide

PLAU PROC

9.79e-0511312CID000071009
DrugAC1L1CD2

DLX4 ESR2

9.79e-0511312CID000027021
Drugbeta-Naphthoflavone

LHCGR MFAP4 TENM2 RCBTB1 KYNU SPON1 ESR2

1.00e-04828317ctd:D019324
DrugNO-cAMP

LHCGR TSHR LATS2

1.13e-0469313CID006426615
Drug4-hydroxybenzophenone

DLX4 ESR2

1.17e-0412312CID000014347
DrugCytarabine

MFAP4 LIMCH1 LY75 KYNU SPON1 TNRC6A

1.35e-04598316ctd:D003561
DrugDiphemanil methylsulfate [62-97-5]; Up 200; 10.2uM; PC3; HT_HG-U133A

LIMCH1 RCBTB1 KYNU SPON1

1.40e-041963144591_UP
DrugLobelanidine hydrochloride [6112-86-3]; Up 200; 10.6uM; MCF7; HT_HG-U133A

PLAU DLX4 SPOCK3 ESR2

1.45e-041983145500_UP
Drugtroglitazone; Up 200; 10uM; HL60; HT_HG-U133A

TSHR LIMCH1 SPON1 ESR2

1.48e-041993146191_UP
DrugSpectrozyme Pl

PLAU PROC

1.62e-0414312CID000128903
Diseaseprimary ovarian insufficiency (implicated_via_orthology)

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

5.77e-33464215DOID:5426 (implicated_via_orthology)
Diseasecongenital heart disease (implicated_via_orthology)

USP17L7 USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18

6.26e-30694215DOID:1682 (implicated_via_orthology)
Diseasepack-years measurement

TENM2 PSMA4

5.93e-063422EFO_0006526
Diseasemitral valve prolapse (is_implicated_in)

PLAU TSHR

7.08e-059422DOID:988 (is_implicated_in)
Diseaseurokinase-type plasminogen activator measurement

PLAU LY75

1.08e-0411422EFO_0010803
DiseaseThromboembolism

PLAU PROC

1.29e-0412422C0040038
DiseaseDeep Vein Thrombosis

PLAU PROC

4.08e-0421422C0149871
DiseaseVenous Thrombosis

PLAU PROC

4.08e-0421422C0042487
DiseaseCoronary heart disease

PLAU ESR2

5.35e-0424422C0010068
DiseaseCerebral Astrocytoma

LATS2 ESR2

5.81e-0425422C0750935
DiseaseIntracranial Astrocytoma

LATS2 ESR2

5.81e-0425422C0750936
Diseasepre-eclampsia (is_implicated_in)

ESR2 PROC

5.81e-0425422DOID:10591 (is_implicated_in)
DiseasePilocytic Astrocytoma

LATS2 ESR2

5.81e-0425422C0334583
DiseaseAstrocytoma

LATS2 ESR2

5.81e-0425422C0004114
DiseaseJuvenile Pilocytic Astrocytoma

LATS2 ESR2

5.81e-0425422C0280783
DiseaseDiffuse Astrocytoma

LATS2 ESR2

5.81e-0425422C0280785
DiseaseGrade I Astrocytoma

LATS2 ESR2

5.81e-0425422C1704230
Diseasebreast cancer (implicated_via_orthology)

PLAU ESR2

5.81e-0425422DOID:1612 (implicated_via_orthology)
DiseaseSubependymal Giant Cell Astrocytoma

LATS2 ESR2

5.81e-0425422C0205768
DiseaseMixed oligoastrocytoma

LATS2 ESR2

5.81e-0425422C0547065
DiseaseChildhood Cerebral Astrocytoma

LATS2 ESR2

5.81e-0425422C0338070
DiseaseGemistocytic astrocytoma

LATS2 ESR2

6.29e-0426422C0334581
DiseaseProtoplasmic astrocytoma

LATS2 ESR2

6.29e-0426422C0334580
DiseaseFibrillary Astrocytoma

LATS2 ESR2

6.29e-0426422C0334582
DiseaseAnaplastic astrocytoma

LATS2 ESR2

6.79e-0427422C0334579
Diseaseselenium measurement

ANKRD44 KYNU

7.84e-0429422EFO_0006331
Diseaseresponse to radiation, prostate carcinoma, erectile dysfunction

CELA2B CELA2A

1.28e-0337422EFO_0001663, EFO_0004234, GO_0009314
DiseaseGraves' disease (is_implicated_in)

TSHR ESR2

1.42e-0339422DOID:12361 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
LQYSSNGKWYHTCGG

CELA2A

46

P08217
NGKWYHTCGGSLIAN

CELA2A

51

P08217
SGYGNSFGAWYQHHS

DLX4

216

Q92988
VYAWGHNGYSQLGNG

RCBTB1

96

Q8NDN9
YYNHAIDWQTGSGCS

LHCGR

426

P22888
ASGYHYGVWSCEGCK

ESR2

156

Q92731
GLCTGFRWTHNSKYY

LATS2

811

Q9NRM7
SGNTYQGYWAQGKRH

JPH1

56

Q9HDC5
GSRWIQYKGHCYKSD

LY75

1536

O60449
CGGNNIGSKSVHWYQ

IGLV3-21

41

P80748
QGYTPLHWACYNGNE

ANKRD44

771

Q8N8A2
CGGNNIGSKAVHWYQ

IGLV3-12

41

A0A075B6K2
SWGEGCGLLHNYGVY

PROC

421

P04070
LQYSSNGQWYHTCGG

CELA2B

46

P08218
YGGWKATCIGNNSAA

PSMA4

156

P25789
YWLGKAANSCTSYSG

LIMCH1

131

Q9UPQ0
GGSHSKNYVLWEYGG

SPON1

236

Q9HCB6
GGTCVSNKYFSNIHW

PLAU

36

P00749
WYTDQRKYGTCPHGG

NARS1

501

O43776
YLGGSHLSYANGINW

MFAP4

221

P55083
SWNPGCTHVYGYAFG

SLC25A41

41

Q8N5S1
QYSKGTCQCYSGWKG

TENM2

616

Q9NT68
NNYCALGCYGGWHLS

IL9R

441

Q01113
AGWSCHNGHYFSYVK

USP17L18

326

D6R9N7
AGWSCHNGHYFSYVK

USP17L5

326

A8MUK1
AGWSCHNGHYFSYVK

USP17L21

326

D6R901
AGWSCHNGHYFSYVK

USP17L13

326

C9JLJ4
AGWSCHNGHYFSYVK

USP17L19

326

D6RCP7
YYKPTQCHGSVGQCW

SPOCK3

346

Q9BQ16
AGWSCHNGHYFSYVK

USP17L12

326

C9JPN9
AGWSCHNGHYFSYVK

USP17L24

326

Q0WX57
AGWSCHNGHYFSYVK

USP17L7

326

P0C7H9
AGWSCHNGHYFSYVK

USP17L6P

326

Q6QN14
AGWSCHNGHYFSYVK

USP17L22

326

D6RA61
AGWSCHNGHYFSYVK

USP17L15

326

C9J2P7
AGWSCHNGHYFSYVK

USP17L17

326

D6RBQ6
CGKGYVTRSGLYQHW

ZNF584

331

Q8IVC4
TWGAYGSNYSGDKCS

TNRC6A

521

Q8NDV7
GGHYITYAKNPNCKW

USP6

1326

P35125
AGWSCHNGHYFSYVK

USP17L20

326

D6RJB6
YWYFSTNGLHGLGQA

ZFYVE16

1081

Q7Z3T8
AGWSCHNGHYSSYVK

USP17L10

326

C9JJH3
AGWSCHNGHYFSYVK

USP17L11

326

C9JVI0
YYNHAIDWQTGPGCN

TSHR

481

P16473
CWCSYKYLNAGAGGI

KYNU

271

Q16719