Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR1 ITPR2

6.54e-063302GO:0005220
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

OSR1 ZNF578 ZNF142 ZNF442 ZNF714 ZFP30 ZNF92 ZFX ZBTB22

1.58e-041412309GO:0000981
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

ITPR1 ITPR2

1.96e-0414302GO:0070679
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

OSR1 ZNF578 ZNF142 ZNF442 ZNF714 ZFP30 ZNF92 ZFX ZBTB22

2.03e-041459309GO:0000977
GeneOntologyMolecularFunctionprotein kinase B binding

CCDC88A RASA1

2.93e-0417302GO:0043422
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

ITPR1 ITPR2

3.29e-0418302GO:0015278
GeneOntologyMolecularFunctionligand-gated calcium channel activity

ITPR1 ITPR2

9.88e-0431302GO:0099604
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

ITPR1 ITPR2

1.12e-0333302GO:0005217
GeneOntologyMolecularFunctiontransmembrane transporter binding

RASA1 ITPR1 ITPR2

2.15e-03172303GO:0044325
GeneOntologyMolecularFunctionion channel inhibitor activity

RASA1 ITPR1

2.36e-0348302GO:0008200
GeneOntologyMolecularFunctionchannel inhibitor activity

RASA1 ITPR1

2.56e-0350302GO:0016248
GeneOntologyMolecularFunctiontransporter inhibitor activity

RASA1 ITPR1

2.66e-0351302GO:0141110
GeneOntologyCellularComponentplatelet dense tubular network membrane

ITPR1 ITPR2

7.12e-059302GO:0031095
GeneOntologyCellularComponentplatelet dense tubular network

ITPR1 ITPR2

1.09e-0411302GO:0031094
DomainZINC_FINGER_C2H2_2

OSR1 DNAJC21 ZC3H7A ZNF578 ZNF609 ZNF142 ZNF442 ZNF714 ZFP30 ZNF92 ZFX ZBTB22

1.04e-097753012PS50157
DomainZINC_FINGER_C2H2_1

OSR1 DNAJC21 ZC3H7A ZNF578 ZNF609 ZNF142 ZNF442 ZNF714 ZFP30 ZNF92 ZFX ZBTB22

1.07e-097773012PS00028
DomainZnf_C2H2-like

OSR1 DNAJC21 ZC3H7A ZNF578 ZNF609 ZNF142 ZNF442 ZNF714 ZFP30 ZNF92 ZFX ZBTB22

1.41e-097963012IPR015880
DomainZnf_C2H2

OSR1 DNAJC21 ZC3H7A ZNF578 ZNF609 ZNF142 ZNF442 ZNF714 ZFP30 ZNF92 ZFX ZBTB22

1.60e-098053012IPR007087
DomainZnF_C2H2

OSR1 DNAJC21 ZC3H7A ZNF578 ZNF609 ZNF142 ZNF442 ZNF714 ZFP30 ZNF92 ZFX ZBTB22

1.67e-098083012SM00355
DomainZnf_C2H2/integrase_DNA-bd

OSR1 DNAJC21 ZNF578 ZNF142 ZNF442 ZNF714 ZFP30 ZNF92 ZFX ZBTB22

7.20e-086943010IPR013087
Domain-

OSR1 ZNF578 ZNF142 ZNF442 ZNF714 ZFP30 ZNF92 ZFX ZBTB22

7.58e-076793093.30.160.60
Domainzf-C2H2

OSR1 ZNF578 ZNF142 ZNF442 ZNF714 ZFP30 ZNF92 ZFX ZBTB22

8.99e-07693309PF00096
DomainInsP3_rcpt-bd

ITPR1 ITPR2

7.48e-063302IPR000493
Domainzf-C2H2_6

OSR1 ZNF578 ZNF442 ZNF714 ZFP30 ZNF92

9.10e-06314306PF13912
DomainRIH_assoc

ITPR1 ITPR2

3.73e-056302PF08454
DomainRIH_assoc-dom

ITPR1 ITPR2

3.73e-056302IPR013662
DomainRYDR_ITPR

ITPR1 ITPR2

3.73e-056302PF01365
DomainRIH_dom

ITPR1 ITPR2

3.73e-056302IPR000699
DomainIns145_P3_rcpt

ITPR1 ITPR2

3.73e-056302IPR014821
DomainRyanodine_recept-rel

ITPR1 ITPR2

3.73e-056302IPR015925
DomainIns145_P3_rec

ITPR1 ITPR2

3.73e-056302PF08709
Domain-

ITPR1 ITPR2

3.73e-0563021.25.10.30
DomainMIR

ITPR1 ITPR2

1.11e-0410302PS50919
DomainMIR

ITPR1 ITPR2

1.11e-0410302PF02815
DomainMIR

ITPR1 ITPR2

1.11e-0410302SM00472
DomainMIR_motif

ITPR1 ITPR2

1.11e-0410302IPR016093
DomainKRAB

ZNF578 ZNF442 ZNF714 ZFP30 ZNF92

2.42e-04358305PS50805
DomainKRAB

ZNF578 ZNF442 ZNF714 ZFP30 ZNF92

2.78e-04369305SM00349
DomainKRAB

ZNF578 ZNF442 ZNF714 ZFP30 ZNF92

2.81e-04370305IPR001909
DomainKRAB

ZNF578 ZNF442 ZFP30 ZNF92

2.45e-03358304PF01352
DomainIon_trans_dom

ITPR1 ITPR2

1.44e-02114302IPR005821
DomainIon_trans

ITPR1 ITPR2

1.44e-02114302PF00520
PathwayREACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION

RASA1 ITPR1 ITPR2

1.98e-0619193M27423
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY

ITPR1 ITPR2

1.72e-055192M49000
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2

2.57e-056192M47960
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2

6.16e-059192M47852
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2

7.70e-0510192M47661
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2

9.40e-0511192M49033
PathwayREACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION

ITPR1 ITPR2

9.40e-0511192M27466
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

1.33e-0413192M47751
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2

1.33e-0413192M47656
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

1.33e-0413192M47696
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2

1.33e-0413192MM14553
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2

2.04e-0416192M26945
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

2.90e-0419192M47760
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2

2.90e-0419192M47733
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

3.22e-0420192M47688
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

3.56e-0421192M47689
PathwayREACTOME_SIGNALING_BY_VEGF

RASA1 ITPR1 ITPR2

3.67e-04106193M27077
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

3.91e-0422192M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

3.91e-0422192M47675
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

4.28e-0423192M47676
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR1 ITPR2

5.07e-0425192MM14511
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR1 ITPR2

5.92e-0427192M12123
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR1 ITPR2

5.92e-0427192MM15053
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR1 ITPR2

6.37e-0428192M924
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR1 ITPR2

8.33e-0432192MM14983
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

ITPR1 ITPR2

1.06e-0336192M1315
PathwayWP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION

ITPR1 ITPR2

1.06e-0336192M39831
PathwayREACTOME_DAG_AND_IP3_SIGNALING

ITPR1 ITPR2

1.37e-0341192M512
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR1 ITPR2

1.43e-0342192M791
PathwayWP_RENINANGIOTENSINALDOSTERONE_SYSTEM_RAAS

ITPR1 ITPR2

1.57e-0344192M39845
PathwaySIG_CHEMOTAXIS

ITPR1 ITPR2

1.65e-0345192M5193
PathwaySIG_BCR_SIGNALING_PATHWAY

ITPR1 ITPR2

1.72e-0346192M8626
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2

2.03e-0350192M47951
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

ITPR1 ITPR2

2.28e-0353192MM15716
PathwayREACTOME_ION_HOMEOSTASIS

ITPR1 ITPR2

2.36e-0354192MM15202
PathwayREACTOME_ION_HOMEOSTASIS

ITPR1 ITPR2

2.36e-0354192M27460
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

ITPR1 ITPR2

2.36e-0354192M26911
PathwayKEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2

2.45e-0355192M47952
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

ITPR1 ITPR2

3.00e-0361192MM15071
PathwayREACTOME_CA2_PATHWAY

ITPR1 ITPR2

3.10e-0362192M27321
PathwayKEGG_LONG_TERM_POTENTIATION

ITPR1 ITPR2

3.94e-0370192M3115
PathwayKEGG_LONG_TERM_DEPRESSION

ITPR1 ITPR2

3.94e-0370192M8232
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

ITPR1 ITPR2

4.16e-0372192MM14631
PathwayWP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY

ITPR1 ITPR2

4.39e-0374192M48080
PathwayWP_ALZHEIMERS_DISEASE

ITPR1 ITPR2

4.39e-0374192MM15962
PathwayKEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM

ITPR1 ITPR2

4.62e-0376192M9052
PathwayREACTOME_PLATELET_HOMEOSTASIS

ITPR1 ITPR2

4.62e-0376192MM15051
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

ITPR1 ITPR2

4.86e-0378192M1921
PathwayREACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS

ITPR1 ITPR2

5.36e-0382192M27110
PathwayREACTOME_PLATELET_HOMEOSTASIS

ITPR1 ITPR2

5.88e-0386192M916
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

ITPR1 ITPR2

5.88e-0386192M601
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

ITPR1 ITPR2

5.88e-0386192M27206
PathwayKEGG_GAP_JUNCTION

ITPR1 ITPR2

6.42e-0390192M4013
PathwayREACTOME_OPIOID_SIGNALLING

ITPR1 ITPR2

6.42e-0390192M6467
PathwayREACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS

ITPR1 ITPR2

7.13e-0395192M29842
PathwayREACTOME_CLEC7A_DECTIN_1_SIGNALING

ITPR1 ITPR2

7.88e-03100192M27467
PathwayKEGG_GNRH_SIGNALING_PATHWAY

ITPR1 ITPR2

8.03e-03101192M1979
PathwayREACTOME_G_ALPHA_I_SIGNALLING_EVENTS

P2RY13 ITPR1 ITPR2

8.14e-03314193M600
PathwayREACTOME_CARDIAC_CONDUCTION

ITPR1 ITPR2

8.34e-03103192MM15196
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

ITPR1 ITPR2

9.13e-03108192M17034
PathwayKEGG_OOCYTE_MEIOSIS

ITPR1 ITPR2

9.96e-03113192M16817
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

ITPR1 ITPR2

1.03e-02115192M9387
Pubmed

Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.

ITPR1 ITPR2

7.19e-07230219120126
Pubmed

An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.

ITPR1 ITPR2

7.19e-07230218708078
Pubmed

Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.

ITPR1 ITPR2

7.19e-07230215201137
Pubmed

Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.

ITPR1 ITPR2

7.19e-07230223582047
Pubmed

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.

ITPR1 ITPR2

2.16e-06330231979185
Pubmed

Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.

ITPR1 ITPR2

2.16e-06330217890015
Pubmed

Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.

ITPR1 ITPR2

2.16e-06330210874040
Pubmed

Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.

ITPR1 ITPR2

2.16e-06330218547250
Pubmed

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

ITPR1 ITPR2

2.16e-0633029808793
Pubmed

Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.

ITPR1 ITPR2

2.16e-06330224904548
Pubmed

Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.

ITPR1 ITPR2

2.16e-06330236350267
Pubmed

Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability.

ITPR1 ITPR2

2.16e-06330232320395
Pubmed

IP3 receptors regulate vascular smooth muscle contractility and hypertension.

ITPR1 ITPR2

2.16e-06330227777977
Pubmed

The versatility and universality of calcium signalling.

ITPR1 ITPR2

2.16e-06330211413485
Pubmed

Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.

ITPR1 ITPR2

2.16e-06330223983250
Pubmed

Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.

ITPR1 ITPR2

2.16e-06330220395455
Pubmed

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2

2.16e-06330217327232
Pubmed

Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.

ITPR1 ITPR2

2.16e-0633029858485
Pubmed

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2

2.16e-06330226009177
Pubmed

Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.

ITPR1 ITPR2

2.16e-06330217581770
Pubmed

Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.

ITPR1 ITPR2

2.16e-06330217437169
Pubmed

Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.

ITPR1 ITPR2

2.16e-06330223223241
Pubmed

Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.

ITPR1 ITPR2

2.16e-06330220427533
Pubmed

Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.

ITPR1 ITPR2

2.16e-06330218241669
Pubmed

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.

ITPR1 ITPR2

2.16e-06330216014380
Pubmed

Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.

ITPR1 ITPR2

2.16e-06330218194433
Pubmed

Receptor-activated single channels in intact human platelets.

ITPR1 ITPR2

2.16e-0633021693919
Pubmed

Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.

ITPR1 ITPR2

2.16e-06330219068129
Pubmed

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

ITPR1 ITPR2

2.16e-06330223955339
Pubmed

Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.

ITPR1 ITPR2

4.31e-06430225215520
Pubmed

IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.

ITPR1 ITPR2

4.31e-06430228419336
Pubmed

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.

ITPR1 ITPR2

4.31e-06430221818117
Pubmed

Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.

ITPR1 ITPR2

4.31e-06430219120137
Pubmed

Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2

4.31e-06430211163362
Pubmed

Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.

ITPR1 ITPR2

4.31e-06430221424589
Pubmed

IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.

ITPR1 ITPR2

4.31e-06430235494252
Pubmed

Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.

ITPR1 ITPR2

4.31e-06430228615414
Pubmed

Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.

ITPR1 ITPR2

4.31e-06430210828023
Pubmed

InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.

ITPR1 ITPR2

7.18e-06530221568942
Pubmed

BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor.

ITPR1 ITPR2

7.18e-06530211782428
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

ITPR1 ITPR2

1.08e-05630216844763
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

ITPR1 ITPR2

1.08e-05630223463619
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

ITPR1 ITPR2

1.08e-05630220519450
Pubmed

Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.

ITPR1 ITPR2

1.08e-05630221762810
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

ITPR1 ITPR2

1.08e-05630225966694
Pubmed

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

ITPR1 ITPR2

1.51e-05730222495310
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

ITPR1 ITPR2

1.51e-05730211860456
Pubmed

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.

ITPR1 ITPR2

2.58e-05930225737585
Pubmed

Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.

ITPR1 ITPR2

3.94e-051130227514653
Pubmed

Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis.

ITPR1 ITPR2

3.94e-051130220824138
Pubmed

Zinc finger protein genes in the mouse genome.

ZFP30 ZFX

4.72e-05123021797234
Pubmed

Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.

ITPR1 ITPR2

6.50e-051430234630045
Pubmed

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.

ITPR1 ITPR2

7.50e-051530228578927
Pubmed

The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity.

ITPR1 ITPR2

1.64e-042230211696558
Pubmed

Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.

ITPR1 ITPR2

1.96e-042430210843712
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

DNAJC21 ZNF609 CCDC88A COQ8A ITPR1

2.17e-0465030538777146
Pubmed

Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.

ITPR1 ITPR2

2.88e-042930232123907
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

ZC3H7A ZNF609 CCDC88A SKA3 ITPR2

3.78e-0473330534672954
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

ITPR1 ITPR2

4.96e-043830230786075
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

OSR1 ZNF578 ZNF609 ZNF142 ZNF442 ZNF714 ZFP30 ZNF92 ZFX ZBTB22

3.85e-09718221028
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR1 ITPR2

4.24e-063222297
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPCPD1 CCDC88A STAC3 LPXN

8.58e-06195304f5351932634d5913688b15f16da76198c91e9b53
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPCPD1 CCDC88A STAC3 LPXN

8.58e-06195304c264b052bc50c5bd92816e12fbbe08014d2002f4
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_2|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

P2RY13 CCDC88A STAC3 LPXN

8.94e-06197304febafd8f0f5bb9a09f496f240e6b6b5e9275669b
ToppCelldistal-Hematologic-Alveolar_Macrophage|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPCPD1 CCDC88A STAC3 LPXN

9.12e-0619830444c9f902af6641dcee4c64c43f83a4047f1a460e
ToppCellSigmoid-Dendritic_cell-cycling_DCs|Sigmoid / Region, Cell class and subclass

P2RY13 SKA3 SPOCK3 STAC3

9.30e-06199304bd6f8c0f79e9a94cc0f8c6105d38851463de821c
ToppCellParenchymal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

P2RY13 GPCPD1 CCDC88A LPXN

9.30e-061993048a7bccf76fdf0b46854750a0a6a5eade0e14e515
ToppCellLPS_anti-TNF-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

USP36 P2RY13 GPCPD1 STAC3

9.30e-0619930476aab03a51681f0ce3369887cf71a884b0998ec5
ToppCellSigmoid-(5)_Dendritic_cell-(52)_cycling_DCs|Sigmoid / shred on region, Cell_type, and subtype

P2RY13 SKA3 SPOCK3 STAC3

9.30e-061993048ee78a39729633bcbb3ab17e1dfaca33f38db569
ToppCellLPS_anti-TNF-Hematopoietic_Myeloid-Granulocytic_cells|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

USP36 P2RY13 GPCPD1 STAC3

9.30e-061993047227e6be56e9f333ee143e1418d22de32a4ca66a
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related-Oligodendrocyte/OPC|GW10 / Sample Type, Dataset, Time_group, and Cell type.

OSR1 STAC3 LPXN

1.41e-041513034533bccc996395f74b16af939ce79b6fe253c073
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related|GW10 / Sample Type, Dataset, Time_group, and Cell type.

OSR1 STAC3 LPXN

1.41e-04151303edb2f59789c295838d2030b80c792cbea25eaa3d
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_4|343B / Donor, Lineage, Cell class and subclass (all cells)

GPCPD1 CCDC88A STAC3

1.70e-041613035cd483b73bcb3615ea56eb81c1c293e61b84b66d
ToppCellNS-control-d_0-4-Myeloid-pDC|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CCDC88A STAC3 ITPR1

1.83e-041653038b2d43d7c4ee07bd999bd51bc15117ce1fbb2d86
ToppCellcontrol-Myeloid-pDC|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CCDC88A STAC3 ITPR1

1.83e-04165303243c74adf8d993ff92acbff2768bdc5a1693eca3
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

OSR1 ZNF578 STAC3

1.93e-04168303d7d19c93d1c3dd994e18e28d5f36ae7773ff5d7f
ToppCelldroplet-Marrow-nan-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OSR1 SLFN12 CCDC88A

1.96e-041693035f5bec13208f4c3b6eacbba180c8a6402743b76e
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

OSR1 ZNF578 STAC3

1.96e-04169303d2def7229fe9d6b0c70cfed349ede491c8c137a0
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLFN12 P2RY13 SKA3

2.03e-041713036e7ade1d14a3ec4c566476aac3eb509bd2661e39
ToppCell367C-Lymphocytic-NK_cells-Proliferating_NK_cell|367C / Donor, Lineage, Cell class and subclass (all cells)

ZNF578 SKA3 SLC6A14

2.03e-041713034ede6e916e593f208f2f8ccf82ef2335e061fc86
ToppCell10x5'-lymph-node_spleen-Hematopoietic_progenitors|lymph-node_spleen / Manually curated celltypes from each tissue

MALRD1 SKA3 SPOCK3

2.14e-04174303029394e107bf7ad58056d2216070aa2e964fff12
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPCPD1 CCDC88A ITPR2

2.14e-04174303d5c22b43531414951666ee7542a66ed9380e2d14
ToppCell367C-Lymphocytic-NK_cells-Proliferating_NK_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZNF578 SKA3 SLC6A14

2.17e-041753030b1aaa028ba844d4bcb4509fdab8bee648373935
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

P2RY13 DNAJC21 SKA3

2.32e-0417930306d412fc096d88de168969466ce422f0ab5553b2
ToppCellmetastatic_Brain-Myeloid_cells-CD207+CD1a+_LCs|metastatic_Brain / Location, Cell class and cell subclass

P2RY13 STAC3 ITPR2

2.36e-0418030351727cb66fe7a7709453f7026e0ff3d6c93d5aa5
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RASA1 IL1RAPL2 SPOCK3

2.40e-041813032f3d04d22d4ac016e61709ea5af3d48885c946c4
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPCPD1 CCDC88A LPXN

2.40e-04181303166ff44fcc0a2943b7f485ea8a9c314964e013bb
ToppCellcellseq2-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC2|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

P2RY13 CCDC88A STAC3

2.48e-041833039840706f972387241bf1d4ba8af25efc3214a91b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MALRD1 ITPR1 ITPR2

2.48e-0418330331ab55d5f3639f5964541d5eae23044dbda3356e
ToppCellcellseq2-Immune-Immune_Myeloid-Myeloid_Dendritic|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

P2RY13 CCDC88A STAC3

2.48e-04183303409cb52cf4c967e52bf75a6680bcbe87f638c75d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RASA1 IL1RAPL2 SPOCK3

2.56e-04185303487fa382232564f075960899d50afa0edae5d258
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MALRD1 ITPR1 ITPR2

2.56e-04185303898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-cDC2|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

P2RY13 CCDC88A STAC3

2.60e-0418630369b107ad88b07e9aeef09d4e4dac99b0cb6b467e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MALRD1 ITPR1 ITPR2

2.64e-04187303b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCellnormal_Lung-Myeloid_cells-pDCs|normal_Lung / Location, Cell class and cell subclass

CCDC88A ZFP30 ZBTB22

2.64e-04187303d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RASA1 IL1RAPL2 SPOCK3

2.64e-0418730302105c82a9ba79d2f19e002188377fc3440770c2
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPCPD1 CCDC88A LPXN

2.64e-041873037b24a324335c30c4b37795c43611b297274c804b
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

USP36 P2RY13 ITPR2

2.68e-04188303cb091912f9b627a78a8793a37df7f1de839f887f
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPCPD1 CCDC88A STAC3

2.72e-04189303bfa1dfc93ad33a9dbef316c0591b950d062b35eb
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPCPD1 CCDC88A STAC3

2.72e-041893031f4fe19e500bfedd48b1f34827a44e796f6db3e1
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

USP36 ZC3H7A C16orf87

2.77e-0419030391ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-naive_B_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

USP36 LPXN ITPR2

2.81e-04191303a073d58154c801ec499fd969f42b7f1ee7f15d79
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GPCPD1 ZNF609 RASA1

2.90e-04193303779276e775cb2492e8dd36436295a536084a6415
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.3|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC88A SKA3 STAC3

2.94e-04194303e5b81a8e52259a54a911c1c2ac932c98c988318d
ToppCell18-Airway-Immune-Hematopoietic,_Macrophage|Airway / Age, Tissue, Lineage and Cell class

P2RY13 STAC3 LPXN

2.94e-041943039671fed8cd45ea8c7a411239aa5012c2a1edf264
ToppCell3'-Distal_airway-Immune_Myeloid|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPCPD1 CCDC88A STAC3

2.99e-041953034df004b8ca7669a57d85c6dffef5b82b4ea1dfdf
ToppCellLAM-Myeloid-Macrophage|LAM / Condition, Lineage and Cell class

GPCPD1 CCDC88A LPXN

2.99e-0419530385abe51e47b567e6edcadfbe8cf02c2f2f0bb133
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_9|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

P2RY13 CCDC88A STAC3

2.99e-04195303dd28c63b53f2a97e3fac127294a465870dc371b3
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

USP36 P2RY13 ITPR2

2.99e-04195303028622b234551b185977fbee10c06851a45456a5
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_9|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

P2RY13 CCDC88A STAC3

2.99e-04195303d6ff38535898f90be6719cd5152291f2f4f8a746
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPCPD1 CCDC88A STAC3

2.99e-041953039e49e59a20b1bbd6167d594c33ab6bdfe2c1ebaf
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPCPD1 CCDC88A STAC3

2.99e-04195303412a9fcf9f075d97fae254bbd89774e4b1face07
ToppCellCOVID-19-kidney-Macrophages|COVID-19 / Disease (COVID-19 only), tissue and cell type

GPCPD1 CCDC88A ITPR2

3.08e-041973033912301018d0863144dcfac8d1fa8adc081748d7
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.0.1.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPCPD1 CCDC88A LPXN

3.08e-04197303aec598543d9a6bd20670bc9855d6531a5ba995fa
ToppCellproximal-Hematologic-Alveolar_Macrophage-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CCDC88A STAC3 LPXN

3.12e-04198303a5deecd8809bc5b38ffda02143598ad0145e2559
ToppCellmedial-Hematologic-Alveolar_Macrophage-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPCPD1 CCDC88A LPXN

3.12e-04198303d64f3d806594619607a72025a93b43ed4efaed01
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D231|Adult / Lineage, Cell type, age group and donor

USP36 GPCPD1 CCDC88A

3.12e-0419830379a415e19cedde13a88f5043d71557363f102322
ToppCellControl-B_intermediate-0|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

CCDC88A C16orf87 LPXN

3.12e-0419830397e66b845053201247e2241739328cd73f33975c
ToppCellmedial-Hematologic-Alveolar_Macrophage|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPCPD1 CCDC88A LPXN

3.12e-041983038a21f885d26959b349eb4ca027328d6cf0f1b9cf
ToppCelldistal-1-Hematologic-Alveolar_Macrophage|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPCPD1 CCDC88A LPXN

3.12e-041983038ce1e5e1b520fe9bc66b15f808c8d1172d1e478c
ToppCellASK428-Immune-Macrophages|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

P2RY13 GPCPD1 CCDC88A

3.12e-041983031d9bd6e13e54308687e56a6b4f3d4e9d411b1cb2
ToppCell390C-Myeloid-Dendritic-cDC2|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

USP36 GPCPD1 LPXN

3.12e-041983038b28e6630dcffa7ca32e959a50f94a0370b78ae0
ToppCelldistal-Hematologic-Alveolar_Macrophage-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPCPD1 CCDC88A LPXN

3.12e-04198303e1dc5a56fc23d3b1b4350d7162acec5762115b64
ToppCellproximal-Hematologic-Alveolar_Macrophage|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CCDC88A STAC3 LPXN

3.12e-04198303ec0092ef6207e788e2c20ddf007a2f6f6e351d0b
ToppCellmedial-2-Hematologic-Alveolar_Macrophage|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPCPD1 CCDC88A LPXN

3.12e-04198303ad8b9ac155737f794bf1974c59f8143c6ef63d71
ToppCellproximal-3-Hematologic-Alveolar_Macrophage|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CCDC88A STAC3 LPXN

3.12e-04198303a5daf11bf7fe614be9f4a0fc6a4b37b5dce2f6fc
ToppCelldistal-Hematologic-Alveolar_Macrophage-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPCPD1 STAC3 LPXN

3.17e-041993032918967da22602404c767d948fed6c4754e53518
ToppCelldistal-3-Hematologic-Alveolar_Macrophage|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPCPD1 STAC3 LPXN

3.17e-04199303f57ba6c711e16fe46f8ddc70223576906b3a710b
ToppCellcellseq2-Immune-Immune_Myeloid-IM|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

P2RY13 CCDC88A STAC3

3.17e-04199303dd3bf59cdc18091889cbf6c43f37100ba537843d
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

P2RY13 CCDC88A ITPR2

3.17e-04199303f34c15df58fbdc6c90e30800e26fabbf828ad10b
ToppCellmLN-Dendritic_cell-cDC2|mLN / Region, Cell class and subclass

P2RY13 CCDC88A STAC3

3.17e-04199303cb17bccb47d04f7793709f9a4376fcc8ce95430c
ToppCellmLN-(5)_Dendritic_cell-(50)_cDC2|mLN / shred on region, Cell_type, and subtype

P2RY13 CCDC88A STAC3

3.17e-041993038d1b18596a0965427abefe0be744c74e4c11d5d3
ToppCellwk_15-18-Hematologic-Myeloid-SPP1+_Mac|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

USP36 P2RY13 ITPR2

3.17e-04199303c7fc2ac1601346aac71e7620a8a440fde8d92dbd
ToppCellcellseq2-Immune-Immune_Myeloid|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

P2RY13 CCDC88A STAC3

3.17e-041993036c3c9eceea20121ae17ae2462134aa0437f591b3
ToppCell(5)_Dendritic_cell|World / shred on Cell_type and subtype

P2RY13 CCDC88A STAC3

3.17e-04199303495de74a918c5c625a2d0ef120fe4162d4ce6e76
ToppCellcellseq2-Immune-Immune_Myeloid-IM-IM|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

P2RY13 CCDC88A STAC3

3.17e-04199303372fb9eb90022dc4ac770a75b4e207c33d1d0c43
ToppCellParenchyma_Control_(B.)-Immune-TX-TRAM-2|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

GPCPD1 CCDC88A STAC3

3.22e-042003037c56935446f10d202eafa1f9ee7cb0aae4c2607e
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Interneuron|3m / Sample Type, Dataset, Time_group, and Cell type.

CCDC88A IL1RAPL2 SPOCK3

3.22e-04200303a313b9a8bde1ea80a6eae183b76fba46b86558b4
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST|Neuronal / cells hierarchy compared to all cells using T-Statistic

RASA1 IL1RAPL2 SPOCK3

3.22e-0420030353d5e427f0cbf5cf0b63efe4ec01da302f555704
ToppCellBiopsy_IPF-Immune-Proliferating_Macrophages|Biopsy_IPF / Sample group, Lineage and Cell type

CCDC88A SKA3 STAC3

3.22e-042003038abb2c25422717e994468ac02d8260344341467f
ToppCellBiopsy_Other_PF-Immune-Macrophages|Biopsy_Other_PF / Sample group, Lineage and Cell type

GPCPD1 CCDC88A LPXN

3.22e-042003039ff5f0371aac2ab528b581fe979a1522579b8b84
ToppCellBiopsy_IPF-Immune-Macrophages|Biopsy_IPF / Sample group, Lineage and Cell type

GPCPD1 CCDC88A LPXN

3.22e-0420030310dfe527791ed0f7724e5a2211a2e13004559646
ToppCell(52)_cycling_DCs|World / shred on Cell_type and subtype

P2RY13 SKA3 STAC3

3.26e-04201303ad2d25d84345fdd593065516a05c5c2b5429eac0
DrugAjmalicine hydrochloride [4373-34-6]; Down 200; 10.2uM; MCF7; HT_HG-U133A

ZNF609 ZNF442 IL1RAPL2 GLG1 ZFX

5.51e-061973055459_DN
DrugDiltiazem hydrochloride [33286-22-5]; Up 200; 8.8uM; MCF7; HT_HG-U133A

USP36 ZNF609 ZNF442 SPOCK3 LPXN

5.51e-061973051532_UP
DrugTetrahydrozoline hydrochloride [522-48-5]; Down 200; 16.8uM; MCF7; HT_HG-U133A

USP36 ZNF609 ZNF442 SLC6A14

1.09e-041903046769_DN
Drugxestospongin C

ITPR1 ITPR2

1.10e-0412302ctd:C511704
DrugButoconazole nitrate [32872-77-1]; Down 200; 8.4uM; HL60; HT_HG-U133A

ZNF609 CCDC88A GLG1 ITPR2

1.18e-041943042427_DN
DrugAminopurine, 6-benzyl [1214-39-7]; Down 200; 17.8uM; MCF7; HT_HG-U133A

ZNF609 GLG1 SLC6A14 ZFX

1.20e-041953044748_DN
DrugMinaprine dihydrochloride [25953-17-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A

USP36 ZNF609 ZNF442 ITPR1

1.20e-041953044814_UP
DrugAmprolium hydrochloride [137-88-2]; Up 200; 12.6uM; MCF7; HT_HG-U133A

ZNF609 ZNF442 ZFP30 ZFX

1.22e-041963044825_UP
DrugNisoxetine hydrochloride [57754-86-6]; Down 200; 13uM; PC3; HT_HG-U133A

SPOCK3 ZFP30 ZFX ITPR1

1.22e-041963045091_DN
DrugFluoxetine hydrochloride [59333-67-4]; Down 200; 11.6uM; PC3; HT_HG-U133A

CCDC88A ZNF442 ITPR1 ITPR2

1.22e-041963046757_DN
Drug2-propylpentanoic acid; Up 200; 200uM; MCF7; HT_HG-U133A

ZNF609 ZNF442 ZFP30 SLC6A14

1.22e-041963046934_UP
DrugKaempferol [520-18-3]; Down 200; 14uM; MCF7; HT_HG-U133A

ZNF609 CCDC88A GLG1 SLC6A14

1.25e-041973043579_DN
DrugEtodolac [41340-25-4]; Up 200; 14uM; PC3; HT_HG-U133A

ZNF609 CCDC88A ZFP30 ITPR1

1.25e-041973042091_UP
DrugBendroflumethiazide [73-48-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A

ZNF609 IL1RAPL2 ITPR1 ITPR2

1.25e-041973043934_DN
DrugDiphenidol hydrochloride [3254-89-5]; Up 200; 11.6uM; MCF7; HT_HG-U133A

ZNF609 CCDC88A ZNF442 ZFX

1.25e-041973047447_UP
Drugfluphenazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A_EA

USP36 ZNF609 LPXN ITPR2

1.25e-041973041017_DN
DrugOrlistat; Down 200; 10uM; PC3; HT_HG-U133A

ZNF609 CCDC88A ZNF442 ZFP30

1.27e-041983046388_DN
DrugNafronyl oxalate [3200-06-4]; Up 200; 8.4uM; MCF7; HT_HG-U133A

SPOCK3 GLG1 LPXN ITPR1

1.27e-041983042622_UP
DrugDydrogesterone [152-62-5]; Up 200; 12.8uM; MCF7; HT_HG-U133A

ZNF609 CCDC88A ZNF442 ZFP30

1.27e-041983044836_UP
DrugDoxylamine succinate [562-10-7]; Up 200; 10.2uM; MCF7; HT_HG-U133A

CCDC88A ZNF442 ZFP30 ITPR2

1.30e-041993044819_UP
DrugDibucaine [85-79-0]; Down 200; 11.6uM; MCF7; HT_HG-U133A

USP36 ZNF609 ZNF442 ZFX

1.30e-041993041469_DN
DrugPivmecillinam hydrochloride [32887-03-9]; Up 200; 8.4uM; HL60; HT_HG-U133A

ZNF609 CCDC88A ZNF442 IL1RAPL2

1.32e-042003042973_UP
DrugGentamicine sulfate [1405-41-0]; Down 200; 2.6uM; PC3; HT_HG-U133A

ZNF609 ZNF442 SPOCK3 ITPR1

1.32e-042003045883_DN
DiseaseBrain Hypoxia

ITPR1 ITPR2

9.99e-072302C1527348
DiseaseAnoxia of brain

ITPR1 ITPR2

9.99e-072302C0995195
DiseaseHypoxic Brain Damage

ITPR1 ITPR2

9.99e-072302C1140716
DiseaseAnoxic Encephalopathy

ITPR1 ITPR2

9.99e-072302C0003132
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR1 ITPR2

6.55e-0512302DOID:1441 (implicated_via_orthology)
DiseaseInherited neuropathies

COQ8A ITPR1

7.61e-0440302C0598589
Diseasefactor VII activating protease measurement

ZNF609 MALRD1

1.44e-0355302EFO_0009368
Diseaseresponse to cranial radiation therapy, short-term memory

DNAJC21 MALRD1

1.71e-0360302EFO_0004335, EFO_0010950
Diseasecongenital heart disease (implicated_via_orthology)

USP36 ITPR1

2.25e-0369302DOID:1682 (implicated_via_orthology)
Diseaseneutrophil percentage of leukocytes

ZC3H7A COQ8A GLG1 ZNF92

3.23e-03610304EFO_0007990
Diseasevelopharyngeal dysfunction

SPOCK3 ITPR2

6.84e-03122302EFO_0009336
Diseasegestational age

MALRD1 SPOCK3

8.67e-03138302EFO_0005112
DiseaseVertigo

MALRD1 SPOCK3

8.79e-03139302HP_0002321

Protein segments in the cluster

PeptideGeneStartEntry
KTKKSKDPDILFMRC

RASA1

661

P20936
KKFRDCLFKVCPMNR

ITPR2

51

Q14571
KKFRDCLFKLCPMNR

ITPR1

51

Q14643
FLRNRPKDKDKMKAC

CCDC88A

1471

Q3V6T2
EKDKKPYCRKDFLAM

LPXN

251

O60711
CPACDKSFKTEKAMK

DNAJC21

316

Q5F1R6
RLPSKTKKEFVCKFC

OSR1

166

Q8TAX0
CKKFTEKLPCMQGRK

P2RY13

321

Q9BPV8
KMQKCDFKYDCPDKS

MALRD1

1066

Q5VYJ5
PMLRKACKADIPKFC

GLG1

936

Q92896
TCCLTMKKKFDADPV

GPCPD1

376

Q9NPB8
AKKVKMATKSCPECD

C16orf87

6

Q6PH81
SKLKARFPCKAMFEE

COQ8A

621

Q8NI60
KRKEISCPDMDDFKK

IL1RAPL2

156

Q9NP60
LKTPKCALKMDDFEC

SKA3

201

Q8IX90
EKPFKCKKCDESFCM

ZNF714

141

Q96N38
KPFKCKNRGKSFCML

ZNF92

171

Q03936
EKPYKCKVCDKAFMC

ZNF578

536

Q96N58
KPFKCKECEKTFRLL

ZFP30

436

Q9Y2G7
CMEKEKCKKPSSLKP

ZNF609

631

O15014
DCFQKNDKKMFKSCR

SLFN12

561

Q8IYM2
AKDPCLKMKCSRHKV

SPOCK3

86

Q9BQ16
LCEKCFDHKPRMISK

ZC3H7A

571

Q8IWR0
MAEKPYECKTCKKAF

ZNF442

511

Q9H7R0
KTKHSKEMPFKCDIC

ZFX

596

P17010
KTHMCPECKRCFKKR

ZNF142

161

P52746
MDKLKCPSFFKCREK

SLC6A14

1

Q9UN76
FFKKPKFCDVCARMI

STAC3

96

Q96MF2
RPFDCPVCNKKFKMK

ZBTB22

511

O15209
MCAKCKKKVPASKRF

USP36

301

Q9P275