Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	retromer complex binding	WASHC2C WASHC2A M6PR	1.38e-05	10	99	3	GO:1905394
Domain	Clathrin_H-chain_propeller_rpt	CLTCL1 CLTC	2.61e-05	2	96	2	IPR022365
Domain	Clathrin-link	CLTCL1 CLTC	2.61e-05	2	96	2	PF09268
Domain	-	CLTCL1 CLTC	2.61e-05	2	96	2	2.130.10.110
Domain	Clathrin_heavy_chain	CLTCL1 CLTC	2.61e-05	2	96	2	IPR016341
Domain	Clathrin_H-chain_propeller_N	CLTCL1 CLTC	2.61e-05	2	96	2	IPR001473
Domain	Clathrin_H-chain_link/propller	CLTCL1 CLTC	2.61e-05	2	96	2	IPR016025
Domain	Clathrin_propel	CLTCL1 CLTC	2.61e-05	2	96	2	PF01394
Domain	Clathrin_H-chain_linker_core	CLTCL1 CLTC	2.61e-05	2	96	2	IPR015348
Domain	FAM21	WASHC2C WASHC2A	2.61e-05	2	96	2	IPR027308
Domain	ARM-type_fold	CLTCL1 PSMD1 NBEA HSPBP1 UNC45A LYST CEBPZ PIK3CG CLTC	6.23e-05	339	96	9	IPR016024
Domain	Clathrin_H-chain_linker	CLTCL1 CLTC	7.82e-05	3	96	2	IPR012331
Domain	Cu-oxidase	F8 HEPH	7.82e-05	3	96	2	PF00394
Domain	CAP-ZIP_m	WASHC2C WASHC2A	7.82e-05	3	96	2	PF15255
Domain	FAM21/CAPZIP	WASHC2C WASHC2A	7.82e-05	3	96	2	IPR029341
Domain	CLH	CLTCL1 CLTC	7.82e-05	3	96	2	SM00299
Domain	Cu-oxidase	F8 HEPH	7.82e-05	3	96	2	IPR001117
Domain	-	CLTCL1 TTC28 TTC14 UNC45A DNAJC7 SMYD4 CLTC	9.61e-05	207	96	7	1.25.40.10
Domain	Cu-oxidase_2	F8 HEPH	1.56e-04	4	96	2	IPR011706
Domain	Cu-oxidase_2	F8 HEPH	1.56e-04	4	96	2	PF07731
Domain	TPR-like_helical_dom	CLTCL1 TTC28 TTC14 UNC45A DNAJC7 SMYD4 CLTC	2.00e-04	233	96	7	IPR011990
Domain	Cu-oxidase_3	F8 HEPH	2.59e-04	5	96	2	IPR011707
Domain	MULTICOPPER_OXIDASE1	F8 HEPH	2.59e-04	5	96	2	PS00079
Domain	Cu_oxidase_CS	F8 HEPH	2.59e-04	5	96	2	IPR033138
Domain	Cu-oxidase_3	F8 HEPH	2.59e-04	5	96	2	PF07732
Domain	PH_BEACH	NBEA LYST	3.87e-04	6	96	2	PF14844
Domain	Cu_oxidase_Cu_BS	F8 HEPH	3.87e-04	6	96	2	IPR002355
Domain	Clathrin	CLTCL1 CLTC	5.40e-04	7	96	2	PF00637
Domain	TPR_11	TTC14 DNAJC7	5.40e-04	7	96	2	PF13414
Domain	CHCR	CLTCL1 CLTC	5.40e-04	7	96	2	PS50236
Domain	Clathrin_H-chain/VPS_repeat	CLTCL1 CLTC	7.17e-04	8	96	2	IPR000547
Domain	PH-BEACH_dom	NBEA LYST	7.17e-04	8	96	2	IPR023362
Domain	-	NBEA LYST	7.17e-04	8	96	2	2.30.29.40
Domain	PH_BEACH	NBEA LYST	7.17e-04	8	96	2	PS51783
Domain	BEACH	NBEA LYST	9.19e-04	9	96	2	PS50197
Domain	Beach	NBEA LYST	9.19e-04	9	96	2	PF02138
Domain	-	NBEA LYST	9.19e-04	9	96	2	1.10.1540.10
Domain	Beach	NBEA LYST	9.19e-04	9	96	2	SM01026
Domain	BEACH_dom	NBEA LYST	9.19e-04	9	96	2	IPR000409
Domain	TPR_1	TTC28 TTC14 UNC45A DNAJC7	1.19e-03	90	96	4	IPR001440
Domain	TPR_1	TTC28 TTC14 UNC45A DNAJC7	1.19e-03	90	96	4	PF00515
Domain	SET	SMYD4 SETD2 KMT2A	1.22e-03	41	96	3	PF00856
Domain	Elongated_TPR_rpt_dom	UNC45A DNAJC7	1.40e-03	11	96	2	IPR023114
Domain	SET	SMYD4 SETD2 KMT2A	1.70e-03	46	96	3	SM00317
Domain	SET_dom	SMYD4 SETD2 KMT2A	2.17e-03	50	96	3	IPR001214
Domain	SET	SMYD4 SETD2 KMT2A	2.17e-03	50	96	3	PS50280
Domain	TPR_2	TTC28 TTC14 UNC45A	2.17e-03	50	96	3	PF07719
Domain	TPR_2	TTC28 TTC14 UNC45A	2.17e-03	50	96	3	IPR013105
Domain	Dynein_heavy_chain_D4_dom	DNAH7 DYNC1H1	2.29e-03	14	96	2	IPR024317
Domain	Dynein_HC_stalk	DNAH7 DYNC1H1	2.29e-03	14	96	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH7 DYNC1H1	2.29e-03	14	96	2	IPR013602
Domain	DHC_N2	DNAH7 DYNC1H1	2.29e-03	14	96	2	PF08393
Domain	-	F8 HEPH	2.29e-03	14	96	2	2.60.40.420
Domain	MT	DNAH7 DYNC1H1	2.29e-03	14	96	2	PF12777
Domain	AAA_8	DNAH7 DYNC1H1	2.29e-03	14	96	2	PF12780
Domain	TPR_8	TTC28 UNC45A DNAJC7	2.56e-03	53	96	3	PF13181
Domain	DHC_fam	DNAH7 DYNC1H1	2.63e-03	15	96	2	IPR026983
Domain	Dynein_heavy	DNAH7 DYNC1H1	2.63e-03	15	96	2	PF03028
Domain	Dynein_heavy_dom	DNAH7 DYNC1H1	2.63e-03	15	96	2	IPR004273
Domain	Post-SET_dom	SETD2 KMT2A	2.99e-03	16	96	2	IPR003616
Domain	PostSET	SETD2 KMT2A	2.99e-03	16	96	2	SM00508
Domain	POST_SET	SETD2 KMT2A	2.99e-03	16	96	2	PS50868
Domain	TPR	TTC28 TTC14 UNC45A DNAJC7	4.42e-03	129	96	4	SM00028
Domain	TPR_repeat	TTC28 TTC14 UNC45A DNAJC7	4.93e-03	133	96	4	IPR019734
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	WASHC2C TTC28 BACH2 DNAJC7 WASHC2A SOX13 KANSL3 SETD2 DROSHA CLTC SIPA1L2 KNL1	1.65e-07	588	102	12	38580884
Pubmed	Molecular and genetic mapping of the mouse mdx locus.	F8 DMD G6PD	2.44e-07	5	102	3	3243547
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ATAD5 FBXL14 PSMD1 SMPD4 NBEA DNAJC7 FAN1 EGFR PTPRM CEBPZ CLTC KCNMA1 DMD G6PD KNL1	4.25e-07	1049	102	15	27880917
Pubmed	Comparison of the physical and recombination maps of the mouse X chromosome.	F8 DMD G6PD	8.50e-07	7	102	3	2571569
Pubmed	Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation.	PSMD1 EGFR CLTC	2.03e-06	9	102	3	17182860
Pubmed	Linkage of a gene for neural cell adhesion molecule, L1 (CamL1) to the Rsvp region of the mouse X chromosome.	F8 DMD G6PD	2.90e-06	10	102	3	1964443
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	WASHC2C TTC28 POGZ WASHC2A KLHL29 SV2B CLTC SIPA1L2 DYNC1H1	3.31e-06	407	102	9	12693553
Pubmed	Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.	CLTCL1 SEC31A CLTC	3.97e-06	11	102	3	29604273
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TTC28 ANXA7 PSMD1 NBEA POGZ ZNF224 SEC31A DNAJC7 FAN1 THOP1 DROSHA CLTC RECK DYNC1H1 ZNF292	5.16e-06	1285	102	15	35914814
Pubmed	Conservation and reorganization of loci on the mammalian X chromosome: a molecular framework for the identification of homologous subchromosomal regions in man and mouse.	F8 DMD G6PD	5.29e-06	12	102	3	2899541
Pubmed	PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis.	ITGAM PIK3CG	8.52e-06	2	102	2	17173040
Pubmed	SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia.	SETD2 KMT2A	8.52e-06	2	102	2	29249820
Pubmed	MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.	SETD2 KMT2A	8.52e-06	2	102	2	29777171
Pubmed	Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis.	ITGAM LYST	8.52e-06	2	102	2	21403131
Pubmed	Characterization of the MLL partner gene AF15q14 involved in t(11;15)(q23;q14).	KMT2A KNL1	8.52e-06	2	102	2	12618768
Pubmed	EPCR deficiency or function-blocking antibody protects against joint bleeding-induced pathology in hemophilia mice.	PROCR F8	8.52e-06	2	102	2	32294155
Pubmed	Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).	WASHC2C WASHC2A	8.52e-06	2	102	2	20827171
Pubmed	FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.	WASHC2C WASHC2A	8.52e-06	2	102	2	36717248
Pubmed	Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling.	EGFR RECK	8.52e-06	2	102	2	20890302
Pubmed	Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.	CLTCL1 CLTC	8.52e-06	2	102	2	8733129
Pubmed	Monosomy of chromosome 10 associated with dysregulation of epidermal growth factor signaling in glioblastomas.	ANXA7 EGFR	8.52e-06	2	102	2	19602687
Pubmed	Abnormal splicing switch of DMD's penultimate exon compromises muscle fibre maintenance in myotonic dystrophy.	MBNL1 DMD	8.52e-06	2	102	2	26018658
Pubmed	Identification of a novel Rev-interacting cellular protein.	WASHC2C WASHC2A	8.52e-06	2	102	2	15847701
Pubmed	CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.	CLTCL1 CLTC	8.52e-06	2	102	2	29097553
Pubmed	Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia.	ITGAM KMT2A	8.52e-06	2	102	2	12515728
Pubmed	The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.	CLTCL1 CLTC	8.52e-06	2	102	2	20065094
Pubmed	Substrate-trapping techniques in the identification of cellular PTP targets.	TEC EGFR PTPRM IRS2	1.33e-05	49	102	4	15588985
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	WASHC2C PSMD1 POGZ ZNF224 INTS3 KANSL3 SETD2 EGFR CLTC KMT2A IRS2	1.75e-05	774	102	11	15302935
Pubmed	Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.	CLTCL1 CLTC	2.55e-05	3	102	2	19509056
Pubmed	Identification of functional cooperative mutations of SETD2 in human acute leukemia.	SETD2 KMT2A	2.55e-05	3	102	2	24509477
Pubmed	Epidermal growth factor receptor-PI3K signaling controls cofilin activity to facilitate herpes simplex virus 1 entry into neuronal cells.	EGFR PIK3CG	2.55e-05	3	102	2	24425731
Pubmed	A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15.	KMT2A KNL1	2.55e-05	3	102	2	12618766
Pubmed	Tenascin-C-EGFR activation induces functional human satellite cell proliferation and promotes wound-healing of skeletal muscles via oleanic acid.	EGFR DMD	2.55e-05	3	102	2	37758009
Pubmed	Transcription factor AP-1 promotes growth and radioresistance in prostate cancer cells.	EGFR PIK3CG	2.55e-05	3	102	2	19787273
Pubmed	A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism.	INPP5B CLTC	2.55e-05	3	102	2	19536138
Pubmed	Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next-generation human artificial chromosomes for Duchenne muscular dystrophy.	LYST DMD	2.55e-05	3	102	2	29242210
Pubmed	Extracellular HspBP1 and Hsp72 synergistically activate epidermal growth factor receptor.	HSPBP1 EGFR	2.55e-05	3	102	2	18986301
Pubmed	The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b.	PROCR ITGAM	2.55e-05	3	102	2	20458145
Pubmed	Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.	CLTCL1 CLTC	2.55e-05	3	102	2	22891263
Pubmed	Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells.	EGFR PIK3CG	2.55e-05	3	102	2	19229860
Pubmed	Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice.	EGFR CLTC	2.55e-05	3	102	2	15294912
Pubmed	Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.	CLTCL1 CLTC	2.55e-05	3	102	2	15133132
Pubmed	Pulse-field linkage of the P3, G6pd and Cf-8 genes on the mouse X chromosome: demonstration of synteny at the physical level.	F8 G6PD	2.55e-05	3	102	2	2922282
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	SEH1L PITRM1 PSMD1 HSPBP1 UNC45A SEPSECS THOP1 PTPRM IRS2 DMD SIPA1L2 G6PD	2.91e-05	974	102	12	28675297
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TTC28 POGZ UNC45A DNAJC7 SETD2 CEBPZ CLTC KMT2A DYNC1H1	3.56e-05	549	102	9	38280479
Pubmed	Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs.	EGFR CLTC M6PR	4.74e-05	24	102	3	37100772
Pubmed	The extent of linkage disequilibrium caused by selection on G6PD in humans.	F8 G6PD	5.09e-05	4	102	2	16020776
Pubmed	Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression.	EGFR RECK	5.09e-05	4	102	2	26026961
Pubmed	Huntingtin-interacting protein 1 phosphorylation by receptor tyrosine kinases.	EGFR CLTC	5.09e-05	4	102	2	23836884
Pubmed	Neurobeachin: A protein kinase A-anchoring, beige/Chediak-higashi protein homolog implicated in neuronal membrane traffic.	NBEA LYST	5.09e-05	4	102	2	11102458
Pubmed	Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways.	EGFR PIK3CG	5.09e-05	4	102	2	19794963
Pubmed	Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome.	DMD G6PD	5.09e-05	4	102	2	2890215
Pubmed	Oncogenic All1 fusion proteins target Drosha-mediated microRNA processing.	DROSHA KMT2A	5.09e-05	4	102	2	17581865
Pubmed	Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia.	POGZ KMT2A	5.09e-05	4	102	2	25082813
Pubmed	Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway.	EGFR PIK3CG	5.09e-05	4	102	2	19917135
Pubmed	Factor XIII activity mediates red blood cell retention in venous thrombi.	ITGAM F8	5.09e-05	4	102	2	24983320
Pubmed	Inhibitory role of proguanil on the growth of bladder cancer via enhancing EGFR degradation and inhibiting its downstream signaling pathway to induce autophagy.	EGFR CLTC	5.09e-05	4	102	2	35614042
Pubmed	HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.	CLTCL1 CLTC	5.09e-05	4	102	2	11517213
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	ATAD5 ANXA7 MBNL1 INTS3 FANCA CENPP SETD2 KNL1	5.87e-05	453	102	8	29656893
Pubmed	Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.	CLTCL1 EGFR CLTC	6.06e-05	26	102	3	24067654
Pubmed	TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.	ANXA7 SEC31A CLTC	7.61e-05	28	102	3	29653964
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	WASHC2C INPP5B MBNL1 TTC14 PSMD1 SEC31A TEC WASHC2A SEPSECS THOP1 GBP4 CLTC	8.12e-05	1084	102	12	11544199
Pubmed	NKX2-5, a modifier of skeletal muscle pathology due to RNA toxicity.	MBNL1 DMD	8.47e-05	5	102	2	25168381
Pubmed	Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.	POGZ KMT2A	8.47e-05	5	102	2	26245978
Pubmed	Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.	CLTCL1 CLTC	8.47e-05	5	102	2	10436022
Pubmed	Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.	CLTC M6PR	8.47e-05	5	102	2	24407285
Pubmed	Serum Quantitative Proteomic Analysis Reveals Soluble EGFR To Be a Marker of Insulin Resistance in Male Mice and Humans.	EGFR IRS2	8.47e-05	5	102	2	29028997
Pubmed	Targeted splice sequencing reveals RNA toxicity and therapeutic response in myotonic dystrophy.	MBNL1 DMD	8.47e-05	5	102	2	33503262
Pubmed	Localization of the region homologous to the Duchenne muscular dystrophy locus on the mouse X chromosome.	DMD G6PD	8.47e-05	5	102	2	3600794
Pubmed	The mapping of a cDNA from the human X-linked Duchenne muscular dystrophy gene to the mouse X chromosome.	DMD G6PD	8.47e-05	5	102	2	3600793
Pubmed	Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.	FAN1 FANCA	8.47e-05	5	102	2	26980189
Pubmed	Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression.	EGFR PIK3CG	8.47e-05	5	102	2	18844239
Pubmed	The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity.	DROSHA DMD	8.47e-05	5	102	2	31686651
Pubmed	Localization of the membrane-anchored MMP-regulator RECK at the neuromuscular junctions.	DMD RECK	8.47e-05	5	102	2	17953659
Pubmed	Nuclear Drosha enhances cell invasion via an EGFR-ERK1/2-MMP7 signaling pathway induced by dysregulated miRNA-622/197 and their targets LAMC2 and CD82 in gastric cancer.	EGFR DROSHA	8.47e-05	5	102	2	28252644
Pubmed	Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP.	CLTCL1 EGFR CLTC	9.39e-05	30	102	3	22963397
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	ANXA7 NBEA DNAJC7 GRID2IP KMT2A IRS2 G6PD ZNF292	1.11e-04	497	102	8	36774506
Pubmed	Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.	PIK3CG CLTC	1.27e-04	6	102	2	12163475
Pubmed	Reduced levels of dystrophin associated proteins in the brains of mice deficient for Dp71.	F8 DMD	1.27e-04	6	102	2	8872469
Pubmed	Sequence of the human factor VIII-associated gene is conserved in mouse.	F8 DMD	1.27e-04	6	102	2	1639415
Pubmed	Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells.	EGFR DROSHA	1.27e-04	6	102	2	31507089
Pubmed	Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium.	PROCR F8	1.27e-04	6	102	2	20231535
Pubmed	EGFR-Aurka Signaling Rescues Polarity and Regeneration Defects in Dystrophin-Deficient Muscle Stem Cells by Increasing Asymmetric Divisions.	EGFR DMD	1.27e-04	6	102	2	30713094
Pubmed	The endothelial protein C receptor plays an essential role in the maintenance of pregnancy.	PROCR F8	1.27e-04	6	102	2	33158859
Pubmed	Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly.	PSMD1 EGFR G6PD DYNC1H1	1.67e-04	93	102	4	38245532
Pubmed	The localization of G6pd, glucose-6-phosphate dehydrogenase, and mdx, muscular dystrophy in the mouse X chromosome.	DMD G6PD	1.77e-04	7	102	2	3243423
Pubmed	Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor.	EGFR CLTC	1.77e-04	7	102	2	19798056
Pubmed	A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.	CLTCL1 CLTC	1.77e-04	7	102	2	19478182
Pubmed	Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.	POGZ KMT2A	1.77e-04	7	102	2	29997176
Pubmed	Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognition.	ANXA7 SEC31A	1.77e-04	7	102	2	20691033
Pubmed	Localization of monoamine oxidase A and B genes on the mouse X chromosome.	F8 DMD	1.77e-04	7	102	2	2573045
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	WASHC2C TTC28 BACH2 UNC45A DNAJC7 WASHC2A DNAH7 CCDC66 SIPA1L2 DYNC1H1	2.09e-04	853	102	10	28718761
Pubmed	Localization of the mdx mutation within the mouse dystrophin gene.	F8 DMD	2.36e-04	8	102	2	2903046
Pubmed	A FAM21-containing WASH complex regulates retromer-dependent sorting.	WASHC2C WASHC2A	2.36e-04	8	102	2	19922874
Pubmed	A genome-wide association study of the Protein C anticoagulant pathway.	PROCR KCTD8	2.36e-04	8	102	2	22216198
Pubmed	X-chromosome gene order in different Mus species crosses.	F8 G6PD	2.36e-04	8	102	2	3416629
Pubmed	TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia.	CLTCL1 PIK3CG CLTC	2.41e-04	41	102	3	19786618
Pubmed	Placentation defects are highly prevalent in embryonic lethal mouse mutants.	WASHC2C PITRM1 SMPD4 WASHC2A	2.47e-04	103	102	4	29539633
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	PSMD1 SEC31A HSPBP1 UNC45A DNAJC7 INTS3 THOP1 EGFR CEBPZ CLTC IRS2 G6PD DYNC1H1	2.56e-04	1415	102	13	28515276
Pubmed	SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking.	EGFR CLTC	3.03e-04	9	102	2	23222715
GeneFamily	WASH complex	WASHC2C WASHC2A	2.13e-04	6	69	2	1331
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA LYST	5.08e-04	9	69	2	1230
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ATAD5 GRM2 FANCA CENPP MED12L NDUFAF6 KNL1	1.17e-07	167	102	7	108ae6221c6edc63c0ec42c42471b3a15a594043
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ATAD5 FANCA CENPP MED12L NDUFAF6 KNL1	2.57e-06	169	102	6	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 NBEA SEC31A CLTC KMT2A DYNC1H1	5.85e-06	195	102	6	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 NBEA SEC31A CLTC KMT2A DYNC1H1	5.85e-06	195	102	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	COPD-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	WASHC2C WASHC2A GBP4 EGFR PTPRM SIPA1L2	6.20e-06	197	102	6	30dbc05ea66892d2e18ff375ffa86d1db7bc4083
Disease	PROSTATE CANCER, HEREDITARY, 1	TTC28 MBNL1 RNASEL KNL1	4.65e-05	60	97	4	C4722327
Disease	tyrosine-protein kinase TEC measurement	TEC TEC	6.39e-05	4	97	2	EFO_0020830
Disease	Prostate cancer, familial	TTC28 MBNL1 RNASEL KNL1	8.05e-05	69	97	4	C2931456
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CAPN11 KCNMA1 DMD	2.27e-04	36	97	3	DOID:11723 (implicated_via_orthology)
Disease	Neurodevelopmental Disorders	POGZ SETD2 KMT2A ZNF292	2.56e-04	93	97	4	C1535926
Disease	Embryonal Rhabdomyosarcoma	SETD2 DMD	2.96e-04	8	97	2	C0206656
Disease	Autosomal Recessive Polycystic Kidney Disease	EGFR PKHD1	3.79e-04	9	97	2	C0085548
Disease	Childhood Medulloblastoma	SMYD4 PIK3CG IRS2	3.86e-04	43	97	3	C0278510
Disease	Melanotic medulloblastoma	SMYD4 PIK3CG IRS2	3.86e-04	43	97	3	C1275668
Disease	Medullomyoblastoma	SMYD4 PIK3CG IRS2	3.86e-04	43	97	3	C0205833
Disease	Desmoplastic Medulloblastoma	SMYD4 PIK3CG IRS2	3.86e-04	43	97	3	C0751291
Disease	Adult Medulloblastoma	SMYD4 PIK3CG IRS2	3.86e-04	43	97	3	C0278876
Disease	Medulloblastoma	SMYD4 PIK3CG IRS2	6.03e-04	50	97	3	C0025149
Disease	lung disease severity measurement	SV2B EHF KCNMA1 PACRG	6.32e-04	118	97	4	EFO_0007744
Disease	severe acute respiratory syndrome, COVID-19	OMA1 ARHGEF28 LYST SEPSECS KCNMA1 DMD SIPA1L2	6.95e-04	447	97	7	EFO_0000694, MONDO_0100096
Disease	Intellectual Disability	PITRM1 NBEA POGZ SETD2 MED12L DYNC1H1 ZNF292	6.95e-04	447	97	7	C3714756
Disease	leukemia	FANCA SETD2 KMT2A	7.98e-04	55	97	3	C0023418
Disease	Diffuse Large B-Cell Lymphoma	SEC31A PIK3CG CLTC	7.98e-04	55	97	3	C0079744
Disease	hair colour measurement	PROCR MBNL1 LYST FANCA PKHD1 MED12L PACRG SIPA1L2	9.68e-04	615	97	8	EFO_0007822
Disease	Insulin Resistance	ITGAM EGFR IRS2	1.03e-03	60	97	3	C0021655
Disease	Insulin Sensitivity	ITGAM EGFR IRS2	1.03e-03	60	97	3	C0920563
Disease	transient cerebral ischemia (implicated_via_orthology)	ITGAM KMT2A G6PD	1.24e-03	64	97	3	DOID:224 (implicated_via_orthology)
Disease	response to acetylsalicylate	OMA1 SETD2	1.25e-03	16	97	2	GO_1903492
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	SETD2 ZNF292	1.41e-03	17	97	2	DOID:0060307 (is_implicated_in)
Disease	sphingosine 1-phosphate measurement	OMA1 DMD	1.58e-03	18	97	2	EFO_0800185
Disease	cystathionine measurement	TEC TEC	1.76e-03	19	97	2	EFO_0010474
Disease	Adenocarcinoma of prostate	FANCA EGFR	1.96e-03	20	97	2	C0007112
Disease	intellectual disability (implicated_via_orthology)	POGZ CAPN11 IRS2	1.96e-03	75	97	3	DOID:1059 (implicated_via_orthology)
Disease	Colorectal Carcinoma	OMA1 ADAM29 GRID1 EGFR PKHD1 DMD TSKS ZNF292	2.22e-03	702	97	8	C0009402
Disease	post-traumatic stress disorder symptom measurement	NBEA SLFN14 PIK3CG	2.53e-03	82	97	3	EFO_0008535
Disease	Leukemia, Myelocytic, Acute	BACH2 FANCA SETD2 KMT2A	2.59e-03	173	97	4	C0023467

Protein segments in the cluster

Peptide	Gene	Start	Entry
QDNDFLSCMSRRSGL	TMEM59L	251	Q9UK28
HNLGMNHDEDTCRCS	ADAM29	336	Q9UKF5
LVSHCLNSLSEFMDN	ATAD5	1641	Q96QE3
FCSQDASDGLQRLHM	PROCR	16	Q9UNN8
LRMHNLEDSCFSFLQ	BACH2	116	Q9BYV9
CRDLSALMHELSNDG	BTBD10	266	Q9BSF8
NMLNAFANEDFSCHG	ANKRD18A	716	Q8IVF6
FSCHGDLNTDQLKMD	ANKRD18A	726	Q8IVF6
CNHRDASMLGSLAYN	GRM2	721	Q14416
ISHGFSMRPDLCAQD	ACMSD	236	Q8TDX5
SGHFERLLVSMCQGN	ANXA7	316	P20073
DQAANLMANRGDHCR	DMD	1736	P11532
MDIFRECDQDHSGTL	CAPN11	646	Q9UMQ6
RLSGNCHMVTFQLEF	CENPP	106	Q6IPU0
LAQQSHMDAFERSFC	POLM	376	Q9NP87
GAIMARCNLDHLGSS	PACRG	216	Q96M98
LQDHQFEFGSCMSKD	RECK	661	O95980
CGSQMHFVRSDELRE	G6PD	446	P11413
FAQATQLGDLHTCLM	INTS3	711	Q68E01
MELNRSESLCHENSF	ARHGEF28	1551	Q8N1W1
DRLSEAGFHMVACNS	KCTD8	281	Q6ZWB6
LDRHCFDRTDSSNSM	MED12L	466	Q86YW9
LIFCLMQFDHNAGQS	KCNMA1	1171	Q12791
CHNRADAENAMRFLT	NCBP2L	86	A6PVI3
HMNAAVTFTNCALGR	AQP7B	96	A0A075B734
EHLICMDSRDSSFGQ	CARF	26	Q8N187
CMLHGVSQEDFLRRN	NDUFAF6	236	Q330K2
REKDDGMNFTQCHTA	KNL1	301	Q8NG31
LANCALNHTDMAFLA	LRRC14B	311	A6NHZ5
NLERHFLMQSDNFCS	GBP4	271	Q96PP9
CHNSDFRNRGMTALL	F8	711	P00451
DIRVFASNCSMHGLG	ASIC3	16	Q9UHC3
DTAMHFGNLVQSICF	PRSS54	136	Q6PEW0
HMGSLRSLNLRSCDN	FBXL14	251	Q8N1E6
HRFAGQMAALCSRDD	SMPD4	756	Q9NXE4
QLMNIRRCGHSDSFF	IRS2	241	Q9Y4H2
ESLAAFRNHTACMEE	EEF1AKMT4-ECE2	746	P0DPD8
DHFLSLQRMFNNCEV	EGFR	46	P00533
ILFLNGLDMRNCSHD	GRID2IP	321	A4D2P6
QEFDINGEHLCSMSL	EHF	76	Q9NZC4
NGEHLCSMSLQEFTR	EHF	81	Q9NZC4
LVNSEMRNFCSHGGA	FANCA	1111	O15360
MRNFCSHGGALTQDI	FANCA	1116	O15360
ALFNMFIDHCRSQLH	DNAH7	2456	Q8WXX0
IFTNAESHCGSLMER	CCDC66	621	A2RUB6
HNATLIFRVCMDSND	LYST	1556	Q99698
GENDCRFAHPADSTM	MBNL1	196	Q9NR56
HLSLGNAMAACRSFQ	DNAJC7	106	Q99615
CLDTGMIDNLSASNH	INPP5B	866	P32019
GSLFSMLHQACRNVA	DYNC1H1	2456	Q14204
CASANALQSLTDAMH	GRID1	96	Q9ULK0
QNSLQCHPEAMEDFR	KANSL3	406	Q9P2N6
TMHGNAARFINHSCE	KMT2A	3896	Q03164
MANIHTFSACLALAD	BBS1	31	Q8NFJ9
DFHGRRMATCSSDQS	SEH1L	21	Q96EE3
AICFLNQMALSHEES	CEBPZ	441	Q03701
NCDEAFSFMDTHNLN	PTPRM	801	P28827
AAAAMGDSLCSFHAN	OTP	191	Q5XKR4
LNRHLDEMCANNDFV	FAN1	56	Q9Y2M0
NAADFCQLSGMHLLV	HSPBP1	136	Q9NZL4
LRHAMANCFEALIGA	DROSHA	1036	Q9NRR4
ASHSQRACLGDLRDM	SOX3	386	P41225
GHSFQIVRDDMLCAG	TPSD1	206	Q9BZJ3
RSLLSDQMGCEFFNL	SLFN14	556	P0C7P3
NTEDMSLCHANRSAA	SMYD4	101	Q8IYR2
DQRRMSLHLHGADCD	TDRD6	1951	O60522
NSTFLEQKEGCHMDL	SV2B	516	Q7L1I2
QRQGHFSRDVLLSMC	TEC	456	P42680
NAQFRVTEALRGHMC	POGZ	381	Q7Z3K3
NRMALESEFVSCQLH	NBEA	2481	Q8NFP9
SCQVNSHFRDGMQAL	HEPH	346	Q9BQS7
HLLNGDNMRCSVNAT	PITRM1	771	Q5JRX3
MHCGTTSDQFLRDNL	PSMD1	376	Q99460
NACDNMGRNALIHAL	RNASEL	196	Q05823
SFCTLTDMQHGQDLE	SIPA1L2	1611	Q9P2F8
RASEGVFCDRMNGIH	PKHD1	2831	P08F94
LTLCHGFNLDTENAM	ITGAM	11	P11215
MNSIKSFSDHAQCGR	NTAN1	106	Q96AB6
MSFICGLQSAARNHV	OMA1	1	Q96E52
MFDRHSSLAGCQIIN	CLTC	141	Q00610
MDGQEFRFAQLCGLH	CLTCL1	1261	P53675
LRGCGTAMLHDFTQQ	PIK3CG	721	P48736
SCDMDGSRHFPESRN	SOX13	406	Q9UN79
TMRSHTQEDPFLCND	ZNF596	101	Q8TC21
VMISCNRHTLADNFN	M6PR	141	P20645
AALDNTHTCVFQDMN	PLCD3	326	Q8N3E9
ANSHIFLCGDLRSMN	TRIM51	296	Q9BSJ1
ECGKAFNRSSNLMEH	ZNF728	316	P0DKX0
MENGSCELHFLATLA	ZNF292	141	O60281
MDRDLLRQSLNCHGS	TTC14	1	Q96N46
DCRLHNVFNDFLMLS	WASHC2C	76	Q9Y4E1
DLSMNLDRSHQGNCA	TSKS	436	Q9UJT2
DATQKGNCSRFMNHS	SETD2	1616	Q9BYW2
GHRAMGSLQQALVCF	TTC28	926	Q96AY4
DCRLHNVFNDFLMLS	WASHC2A	76	Q641Q2
SRLFSLLCDNMEADH	ZBED9	1036	Q6R2W3
HELAIMDSNNFLGNC	SEPSECS	56	Q9HD40
NECGKSFSHMSGLRN	ZNF782	481	Q6ZMW2
CEECGMSFSQRSNLH	ZNF239	321	Q16600
DMCFSQASSLRLHQN	ZNF224	686	Q9NZL3
NFESAVDLCLHDNRM	SEC31A	581	O94979
QLCSQAEFAMFSGTH	THOP1	481	P52888
VAESMRCHLNFDPNS	SOCS6	336	O14544
LHLNCSGLQNFEALM	UNC45A	741	Q9H3U1
NMNHSRQFCSAVVLD	KLHL29	806	Q96CT2