Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	thiamine pyrophosphate binding	TKTL1 OGDH	7.83e-05	8	34	2	GO:0030976
GeneOntologyMolecularFunction	potassium ion leak channel activity	KCNK12 KCNK17	3.33e-04	16	34	2	GO:0022841
GeneOntologyMolecularFunction	narrow pore channel activity	KCNK12 KCNK17	4.73e-04	19	34	2	GO:0022842
GeneOntologyMolecularFunction	leak channel activity	KCNK12 KCNK17	4.73e-04	19	34	2	GO:0022840
GeneOntologyMolecularFunction	outward rectifier potassium channel activity	KCNK12 KCNK17	9.62e-04	27	34	2	GO:0015271
GeneOntologyMolecularFunction	telomeric DNA binding	SMG7 XRCC6	2.11e-03	40	34	2	GO:0042162
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1H KCNK12 KCNK17	2.18e-03	152	34	3	GO:0022843
GeneOntologyMolecularFunction	quaternary ammonium group binding	TKTL1 OGDH	2.78e-03	46	34	2	GO:0050997
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1H KCNK12 KCNK17	3.62e-03	182	34	3	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1H KCNK12 KCNK17	3.73e-03	184	34	3	GO:0022832
Domain	Transketolase-like_Pyr-bd	TKTL1 OGDH	8.95e-05	8	34	2	IPR005475
Domain	Transket_pyr	TKTL1 OGDH	8.95e-05	8	34	2	SM00861
Domain	Transket_pyr	TKTL1 OGDH	8.95e-05	8	34	2	PF02779
Domain	THDP-binding	TKTL1 OGDH	2.48e-04	13	34	2	IPR029061
Domain	-	TKTL1 OGDH	2.48e-04	13	34	2	3.40.50.970
Domain	2pore_dom_K_chnl	KCNK12 KCNK17	3.33e-04	15	34	2	IPR003280
Domain	K_chnl_dom	KCNK12 KCNK17	6.61e-04	21	34	2	IPR013099
Domain	Ion_trans_2	KCNK12 KCNK17	6.61e-04	21	34	2	PF07885
Domain	C-type_lectin_CS	SELE CLEC17A	2.77e-03	43	34	2	IPR018378
Domain	EGF	SELE FRAS1 CNTNAP5	8.83e-03	235	34	3	SM00181
Domain	C_TYPE_LECTIN_1	SELE CLEC17A	9.30e-03	80	34	2	PS00615
Domain	Lectin_C	SELE CLEC17A	1.02e-02	84	34	2	PF00059
Domain	CLECT	SELE CLEC17A	1.02e-02	84	34	2	SM00034
Domain	EGF-like_dom	SELE FRAS1 CNTNAP5	1.03e-02	249	34	3	IPR000742
Pubmed	Relationship between circulating E-selectin, DD genotype of angiotensin-converting-enzyme, and cardiovascular damage in central obese subjects.	SELE ACE	1.04e-06	2	36	2	12898464
Pubmed	Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels.	KCNK12 KCNK17	3.12e-06	3	36	2	11263999
Pubmed	Recombinant human ZP3-induced sperm acrosome reaction: evidence for the involvement of T- and L-type voltage-gated calcium channels.	CACNA1H ZP4	6.24e-06	4	36	2	20394732
Pubmed	Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitis.	KIR2DS3 HLA-B	1.04e-05	5	36	2	16508981
Pubmed	Genetic associations of killer immunoglobulin like receptors and class I human leukocyte antigens on childhood acute lymphoblastic leukemia among north Indians.	KIR2DS3 HLA-B	1.04e-05	5	36	2	26472014
Pubmed	Genome-wide association study of multiplex schizophrenia pedigrees.	CNTNAP5 EXOC2	1.56e-05	6	36	2	22885689
Pubmed	Serum angiotensin-1 converting enzyme activity processes a human immunodeficiency virus 1 gp160 peptide for presentation by major histocompatibility complex class I molecules.	HLA-B ACE	2.18e-05	7	36	2	1316930
Pubmed	Association of maternal histocompatibility at class II HLA loci with maternal microchimerism in the fetus.	HLA-B ACE	2.18e-05	7	36	2	15128924
Pubmed	Candidate gene polymorphism in cardiovascular disease: the BIP cohort.	SELE ACE	2.91e-05	8	36	2	16544732
Pubmed	Dicer is required for proliferation, viability, migration and differentiation in corticoneurogenesis.	RND2 DICER1	3.73e-05	9	36	2	22898830
Pubmed	Identification of transcripts with enriched expression in the developing and adult pancreas.	SPDEF SARAF FOXA1 LARS2 ACE DICER1	4.01e-05	624	36	6	18554416
Pubmed	Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.	EXOC2 HLA-B	4.66e-05	10	36	2	25261932
Pubmed	Association of killer cell immunoglobulin-like receptors with primary Sjogren's syndrome.	KIR2DS3 HLA-B	6.83e-05	12	36	2	19181658
Pubmed	Genetic influences on lipid metabolism trait variability within the Stanislas Cohort.	SELE ACE	6.83e-05	12	36	2	11714857
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	FRAS1 EXOC2 OGDH XRCC6	7.69e-05	219	36	4	31353912
Pubmed	Genetic influences on blood pressure within the Stanislas Cohort.	SELE ACE	8.07e-05	13	36	2	15076187
Pubmed	KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma.	KIR2DS3 HLA-B	8.07e-05	13	36	2	19934297
Pubmed	Candidate gene polymorphisms in cardiovascular disease: a comparative study of frequencies between a French and an Italian population.	SELE ACE	1.08e-04	15	36	2	11341749
Pubmed	Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy.	KIR2DS3 HLA-B	1.08e-04	15	36	2	19850842
Pubmed	Killer immunoglobulin-like receptors (KIR2DL2 and/or KIR2DS2) in presence of their ligand (HLA-C1 group) protect against chronic myeloid leukaemia.	KIR2DS3 HLA-B	1.08e-04	15	36	2	19493232
Pubmed	Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.	SELE ACE	1.24e-04	16	36	2	10391210
Pubmed	No association of KIR genes with Behcet's disease.	KIR2DS3 HLA-B	1.24e-04	16	36	2	17868255
Pubmed	Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.	KIR2DS3 HLA-B	1.24e-04	16	36	2	20331834
Pubmed	Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation.	KIR2DS3 HLA-B	1.40e-04	17	36	2	19032228
Pubmed	The beneficial impact of missing KIR ligands and absence of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population.	KIR2DS3 HLA-B	1.40e-04	17	36	2	20173784
Pubmed	The role of killer immunoglobulin-like receptor haplotypes on the outcome of unrelated donor haematopoietic SCT for thalassaemia.	KIR2DS3 HLA-B	1.40e-04	17	36	2	20173792
Pubmed	Role of killer cell immunoglobulin-like receptor gene content and human leukocyte antigen-C group in susceptibility to human T-lymphotropic virus 1-associated myelopathy/tropical spastic paraparesis in Peru.	KIR2DS3 HLA-B	1.40e-04	17	36	2	20483367
Pubmed	[Effects of killer immunoglobulin-like receptor and human leukocyte antigen class I ligand on the prognosis of related donor hematopoietic stem cell transplantation].	KIR2DS3 HLA-B	1.40e-04	17	36	2	19968064
Pubmed	Variation in immune response genes and chronic Q fever. Concepts: preliminary test with post-Q fever fatigue syndrome.	SELE HLA-B	1.40e-04	17	36	2	12595908
Pubmed	KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation.	KIR2DS3 HLA-B	1.40e-04	17	36	2	19169284
Pubmed	Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis.	KIR2DS3 HLA-B	1.58e-04	18	36	2	19630074
Pubmed	Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.	KIR2DS3 HLA-B	1.58e-04	18	36	2	20519398
Pubmed	Signatures of natural selection and coevolution between killer cell immunoglobulin-like receptors (KIR) and HLA class I genes.	KIR2DS3 HLA-B	1.58e-04	18	36	2	20200544
Pubmed	Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection.	KIR2DS3 HLA-B	1.58e-04	18	36	2	19846535
Pubmed	Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes.	KIR2DS3 HLA-B	1.58e-04	18	36	2	20580654
Pubmed	Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela.	KIR2DS3 HLA-B	1.58e-04	18	36	2	20210918
Pubmed	KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease.	KIR2DS3 HLA-B	1.76e-04	19	36	2	18571006
Pubmed	Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil.	KIR2DS3 HLA-B	1.76e-04	19	36	2	18778326
Pubmed	Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors.	KIR2DS3 HLA-B	1.76e-04	19	36	2	20600442
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian population from the state of Paraná.	KIR2DS3 HLA-B	1.76e-04	19	36	2	18848853
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	CACNA1H FRAS1 ABCA12 XRCC6 DSE	1.77e-04	513	36	5	25798074
Pubmed	Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay.	KIR2DS3 HLA-B	1.96e-04	20	36	2	20193031
Pubmed	HLA and KIR frequencies in Sicilian Centenarians.	KIR2DS3 HLA-B	1.96e-04	20	36	2	20426625
Pubmed	Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.	KIR2DS3 HLA-B	2.16e-04	21	36	2	19861144
Pubmed	Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen.	SELE ACE	2.38e-04	22	36	2	12871600
Pubmed	Distribution of KIR genes in the population of unrelated individuals homozygous for ancestral haplotype AH8.1 (HLA-A1B8DR3).	KIR2DS3 HLA-B	2.38e-04	22	36	2	20492596
Pubmed	Immunogenetic characteristics of patients with autoimmune gastritis.	KIR2DS3 HLA-B	4.16e-04	29	36	2	20082482
Pubmed	The DNA sequence and analysis of human chromosome 6.	SPDEF EXOC2 KCNK17 KIF13A DSE	4.29e-04	622	36	5	14574404
Pubmed	Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis.	KIR2DS3 HLA-B	6.07e-04	35	36	2	19683555
Pubmed	Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator.	OGDH XRCC6	6.42e-04	36	36	2	24147044
Cytoband	7p22.1	RSPH10B2 RSPH10B	6.32e-04	47	36	2	7p22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2q23	ARL6IP6 GALNT13	8.03e-04	53	36	2	chr2q23
GeneFamily	Potassium two pore domain channel subfamily K	KCNK12 KCNK17	1.61e-04	15	23	2	277
Disease	Granulosa Cell Cancer	CMKLR1 DICER1	1.21e-05	5	33	2	C1567257
Disease	mitral valve prolapse (is_implicated_in)	HLA-B ACE	4.35e-05	9	33	2	DOID:988 (is_implicated_in)
Disease	diffuse large B-cell lymphoma	EXOC2 HLA-B	1.09e-04	14	33	2	EFO_0000403
Disease	sarcoidosis (is_implicated_in)	HLA-B ACE	1.44e-04	16	33	2	DOID:11335 (is_implicated_in)
Disease	ankylosing spondylitis (is_implicated_in)	HLA-B ACE	2.05e-04	19	33	2	DOID:7147 (is_implicated_in)
Disease	COVID-19 (is_implicated_in)	HLA-B ACE	2.51e-04	21	33	2	DOID:0080600 (is_implicated_in)
Disease	IgA glomerulonephritis (is_implicated_in)	SELE ACE	5.17e-04	30	33	2	DOID:2986 (is_implicated_in)
Disease	Drug Allergy	HLA-B ACE	7.05e-04	35	33	2	C0013182
Disease	Cardiovascular Diseases	SELE ACE	7.46e-04	36	33	2	C0007222
Disease	Behcet's disease (is_implicated_in)	HLA-B ACE	7.46e-04	36	33	2	DOID:13241 (is_implicated_in)
Disease	hepatocellular carcinoma (is_implicated_in)	FOXA1 ACE DICER1	1.08e-03	181	33	3	DOID:684 (is_implicated_in)
Disease	ornithine measurement	OGDH GALNT13	1.11e-03	44	33	2	EFO_0009776

Protein segments in the cluster

Peptide	Gene	Start	Entry
NGYVDAGDSWRSMYE	ACE	816	P12821
DSYSGYIVDDAFSWT	ABCA12	186	Q86UK0
SDFEDFDYSSWDAMC	DICER1	1496	Q9UPY3
FDYSSWDAMCYLDPS	DICER1	1501	Q9UPY3
AWDSYRSMSESYTLE	RBL2	66	Q08999
YASGAMYDGEWVSNK	RSPH10B	301	P0C881
YASGAMYDGEWVSNK	RSPH10B2	301	B2RC85
KSCVWTFDAYYDMTE	FRAS1	3431	Q86XX4
CAASGFTFSDYYMSW	IGHV3-11	41	P01762
MSADFTSENFSAAWY	EXOC2	156	Q96KP1
ASAMYTSVEGWDYVD	KCNK12	231	Q9HB15
SHMEGWSYTEGFYFA	KCNK17	201	Q96T54
AWSYNTSTEAMTYDE	SELE	21	P16581
MYWMDDTGYSEKATF	DSE	616	Q9UL01
SWSSYDMYHLSTEGE	KIR2DS3	151	Q14952
ETWAGSHSMRYFYTS	HLA-B	21	P01889
EYMAGSDMTYGGFNW	GALNT13	246	Q8IUC8
KMEGHETSDWNSYYA	FOXA1	6	P55317
SGTSSNYVEEMYCAW	OGDH	51	Q02218
MWVAVASAYSYSDDE	DENND4C	1376	Q5VZ89
YNGMASTSSWAALYF	CACNA1H	981	O95180
MDHCWDSFIYESSAF	CFAP47	2791	Q6ZTR5
RYGSSDWVTSYSLMF	CNTNAP5	96	Q8WYK1
AFDYCFWSMDESNTT	KIF13A	56	Q9H1H9
ETDTMDTFVDSAWYY	LARS2	516	Q15031
YYYKWSSADSCNMSG	SARAF	161	Q96BY9
VPEFYWDSSYSMADN	SMG7	866	Q92540
SWTVTYFDSFEPGMF	ARL6IP6	171	Q8N6S5
ITYAAMDYHWVFGTA	CMKLR1	96	Q99788
YYFSPSTKSWDEARM	CLEC17A	266	Q6ZS10
ELNMWDTSGSSYYDN	RND2	56	P52198
MSGWESYYKTEGDEE	XRCC6	1	P12956
SYFDMLYPEDSSWAA	SPDEF	61	O95238
MYGVYNTFTTEERWA	ZNF770	126	Q6IQ21
GYLWSEVYSMDMFHT	THOP1	611	P52888
EGSVWEAMAFASYYS	TKTL1	131	P51854
YSSCYVTEWDSHYIM	ZP4	91	Q12836