Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionGTPase activator activity

AGAP5 RASA3 ARHGAP17 TSC2 PREX2 DOCK5 NF1 LLGL1 AGAP7P AGAP4 AGAP6

1.05e-0527915311GO:0005096
GeneOntologyMolecularFunctionABC-type transporter activity

ABCC1 ABCC4 ABCB1 ABCB4 ATP13A3

3.59e-05491535GO:0140359
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

AGAP5 RASA3 ARHGAP17 TSC2 SIRPB1 PREX2 DOCK5 ARFGEF3 RIC8B NF1 LLGL1 AGAP7P AGAP4 AGAP6

3.69e-0550715314GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

AGAP5 RASA3 ARHGAP17 TSC2 SIRPB1 PREX2 DOCK5 ARFGEF3 RIC8B NF1 LLGL1 AGAP7P AGAP4 AGAP6

3.69e-0550715314GO:0030695
GeneOntologyMolecularFunctiontRNA (guanine) methyltransferase activity

THUMPD3 TRMT10A TRMT5

9.22e-05121533GO:0016423
GeneOntologyMolecularFunctionceramide floppase activity

ABCB1 ABCB4

1.74e-0431532GO:0099038
GeneOntologyMolecularFunctionABC-type xenobiotic transporter activity

ABCC1 ABCC4 ABCB1

1.88e-04151533GO:0008559
GeneOntologyMolecularFunctionefflux transmembrane transporter activity

ABCC1 ABCC4 ABCB1

2.30e-04161533GO:0015562
GeneOntologyMolecularFunctionphospholipid binding

AGAP5 NUMA1 PLEKHA4 ENTHD1 PLA2G4E SNX19 NF1 MCTP1 PLA2G4B AGAP7P AGAP4 MPPE1 AGAP6

3.14e-0454815313GO:0005543
GeneOntologyMolecularFunctionsphingolipid floppase activity

ABCB1 ABCB4

3.46e-0441532GO:0046623
GeneOntologyMolecularFunctionsphingolipid transporter activity

ABCC1 ABCB1 ABCB4

4.57e-04201533GO:0046624
GeneOntologyMolecularFunctionenzyme activator activity

AGAP5 RASA3 ARHGAP17 TSC2 PREX2 NLRC4 DOCK5 NF1 LLGL1 AGAP7P AGAP4 AGAP6 MAPK8IP2 NSMAF

5.33e-0465615314GO:0008047
GeneOntologyMolecularFunctionglucokinase activity

HK2 GCK

5.75e-0451532GO:0004340
GeneOntologyMolecularFunctionhexokinase activity

HK2 GCK

5.75e-0451532GO:0004396
GeneOntologyMolecularFunctionfructokinase activity

HK2 GCK

5.75e-0451532GO:0008865
GeneOntologyMolecularFunctioncytoskeletal protein binding

NPHS1 TPR DIP2B CTTNBP2 NUMA1 TOGARAM2 CLASP2 USH1C SPATA31A6 PRUNE1 FMNL3 MYO3A NF1 LLGL1 MYO3B KIF19 PLEC MAPK8IP2 FRMD3

7.58e-04109915319GO:0008092
GeneOntologyMolecularFunctionMAP kinase kinase kinase kinase activity

MAP4K3 MAP4K2

8.57e-0461532GO:0008349
GeneOntologyMolecularFunctiontelomerase inhibitor activity

POT1 PIF1

8.57e-0461532GO:0010521
GeneOntologyMolecularFunctionglutathione transmembrane transporter activity

ABCC1 ABCC4

1.19e-0371532GO:0034634
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCC1 ABCC4 ABCB1 ABCB4 ATP13A3

1.52e-031091535GO:0042626
GeneOntologyMolecularFunctionABC-type glutathione S-conjugate transporter activity

ABCC1 ABCC4

1.58e-0381532GO:0015431
GeneOntologyMolecularFunctionphosphatidylcholine floppase activity

ABCB1 ABCB4

1.58e-0381532GO:0090554
GeneOntologyBiologicalProcessinner ear receptor cell stereocilium organization

TECTA USH1C MYO3A MYO3B ANKRD24 OTOG

2.32e-06531506GO:0060122
GeneOntologyBiologicalProcessauditory receptor cell morphogenesis

TECTA USH1C MYO3A MYO3B ANKRD24

2.78e-06311505GO:0002093
GeneOntologyBiologicalProcesssphingolipid translocation

ABCC1 ABCB1 ABCB4

3.73e-0651503GO:0099039
GeneOntologyBiologicalProcessinner ear receptor cell differentiation

TECTA USH1C MYO3A MYO3B HEY2 ANKRD24 OTOG

6.49e-06961507GO:0060113
GeneOntologyBiologicalProcessinner ear auditory receptor cell differentiation

TECTA USH1C MYO3A MYO3B HEY2 ANKRD24

9.27e-06671506GO:0042491
GeneOntologyBiologicalProcessauditory receptor cell development

TECTA USH1C MYO3A MYO3B ANKRD24

1.02e-05401505GO:0060117
GeneOntologyBiologicalProcessmechanoreceptor differentiation

TECTA USH1C MYO3A MYO3B HEY2 ANKRD24 OTOG

1.10e-051041507GO:0042490
GeneOntologyBiologicalProcessinner ear receptor cell development

TECTA USH1C MYO3A MYO3B ANKRD24 OTOG

1.52e-05731506GO:0060119
GeneOntologyBiologicalProcesshair cell differentiation

TECTA USH1C MYO3A MYO3B HEY2 ANKRD24

2.23e-05781506GO:0035315
GeneOntologyBiologicalProcessregulation of GTPase activity

AGAP5 RASA3 POT1 ARHGAP17 TSC2 PLXND1 PREX2 NF1 AGAP7P AGAP4 AGAP6

3.52e-0533515011GO:0043087
GeneOntologyBiologicalProcessauditory receptor cell stereocilium organization

TECTA MYO3A MYO3B ANKRD24

3.55e-05261504GO:0060088
GeneOntologyBiologicalProcessRac protein signal transduction

ARHGAP17 KBTBD7 DOCK5 NF1 HACE1

7.53e-05601505GO:0016601
GeneOntologyBiologicalProcessceramide translocation

ABCB1 ABCB4

1.57e-0431502GO:0099040
GeneOntologyBiologicalProcesstRNA N1-guanine methylation

TRMT10A TRMT5

1.57e-0431502GO:0002939
DomainARM-type_fold

USP34 NCAPD3 WAPL TOGARAM2 TSC2 CLASP2 IPO4 RYR3 FMNL3 DOCK5 ARFGEF3 RIC8B NF1 STAG3 TANGO6

9.13e-0833914915IPR016024
DomainPH_dom-like

AGAP5 RASA3 PLEKHA4 PREX2 PTPN13 MTMR3 OSBPL6 PLCG2 AGAP7P AGAP4 AGAP6 MAPK8IP2 NSMAF FRMD3

8.25e-0642614914IPR011993
DomainABC_membrane

ABCC1 ABCC4 ABCB1 ABCB4

3.65e-05241494PF00664
DomainABC_TM1F

ABCC1 ABCC4 ABCB1 ABCB4

6.86e-05281494PS50929
DomainABC1_TM_dom

ABCC1 ABCC4 ABCB1 ABCB4

6.86e-05281494IPR011527
Domain-

AGAP5 RASA3 PLEKHA4 PREX2 PTPN13 MTMR3 OSBPL6 PLCG2 AGAP4 AGAP6 MAPK8IP2 FRMD3

7.22e-05391149122.30.29.30
Domain-

NCAPD3 TOGARAM2 TSC2 CLASP2 IPO4 RIC8B NF1 STAG3 TANGO6

7.45e-0522214991.25.10.10
DomainArfGap

AGAP5 AGAP7P AGAP4 AGAP6

7.91e-05291494SM00105
DomainARFGAP

AGAP5 AGAP7P AGAP4 AGAP6

7.91e-05291494PS50115
DomainArfGap

AGAP5 AGAP7P AGAP4 AGAP6

7.91e-05291494PF01412
DomainArfGAP

AGAP5 AGAP7P AGAP4 AGAP6

7.91e-05291494IPR001164
DomainARM-like

NCAPD3 TOGARAM2 TSC2 CLASP2 IPO4 RIC8B NF1 STAG3 TANGO6

3.24e-042701499IPR011989
DomainABC_transporter_CS

ABCC1 ABCC4 ABCB1 ABCB4

3.44e-04421494IPR017871
DomainC2_dom

RASA3 PLA2G4E MCTP1 PLA2G4B OSBPL6 PLCG2 WWC1

3.50e-041641497IPR000008
DomainCLASP_N

TOGARAM2 CLASP2

3.75e-0441492PF12348
DomainCLASP_N_dom

TOGARAM2 CLASP2

3.75e-0441492IPR024395
DomainMAPKKKK

MAP4K3 MAP4K2

3.75e-0441492IPR021160
DomainPH

AGAP5 RASA3 PLEKHA4 PREX2 OSBPL6 PLCG2 AGAP7P AGAP4 AGAP6

4.00e-042781499SM00233
DomainPH_DOMAIN

AGAP5 RASA3 PLEKHA4 PREX2 OSBPL6 PLCG2 AGAP7P AGAP4 AGAP6

4.11e-042791499PS50003
DomainPH_domain

AGAP5 RASA3 PLEKHA4 PREX2 OSBPL6 PLCG2 AGAP7P AGAP4 AGAP6

4.22e-042801499IPR001849
DomainABC_tran

ABCC1 ABCC4 ABCB1 ABCB4

5.76e-04481494PF00005
DomainABC_TRANSPORTER_2

ABCC1 ABCC4 ABCB1 ABCB4

5.76e-04481494PS50893
DomainHexokinase_2

HK2 GCK

6.22e-0451492PF03727
DomainHexokinase_BS

HK2 GCK

6.22e-0451492IPR019807
DomainHexokinase_C

HK2 GCK

6.22e-0451492IPR022673
DomainHexokinase_N

HK2 GCK

6.22e-0451492IPR022672
DomainHexokinase_1

HK2 GCK

6.22e-0451492PF00349
DomainHEXOKINASE_2

HK2 GCK

6.22e-0451492PS51748
DomainDMAP_binding

DIP2B DIP2A

6.22e-0451492PF06464
DomainHEXOKINASE_1

HK2 GCK

6.22e-0451492PS00378
DomainABC_TRANSPORTER_1

ABCC1 ABCC4 ABCB1 ABCB4

6.24e-04491494PS00211
DomainC2

RASA3 PLA2G4E MCTP1 PLA2G4B PLCG2 WWC1

6.42e-041311496PF00168
DomainABC_transporter-like

ABCC1 ABCC4 ABCB1 ABCB4

6.74e-04501494IPR003439
DomainDMAP1-bd

DIP2B DIP2A

9.29e-0461492IPR010506
DomainHexokinase

HK2 GCK

9.29e-0461492IPR001312
DomainDMAP_binding

DIP2B DIP2A

9.29e-0461492SM01137
DomainANK

AGAP5 CTTNBP2 ANKLE1 HACE1 ANKRD24 AGAP7P AGAP4 AGAP6

9.30e-042511498SM00248
DomainANK_REPEAT

AGAP5 CTTNBP2 ANKLE1 HACE1 ANKRD24 AGAP7P AGAP4 AGAP6

9.79e-042531498PS50088
DomainC2

RASA3 PLA2G4E MCTP1 PLA2G4B PLCG2 WWC1

9.79e-041421496PS50004
DomainAnkyrin_rpt-contain_dom

AGAP5 CTTNBP2 ANKLE1 HACE1 ANKRD24 AGAP7P AGAP4 AGAP6

1.00e-032541498IPR020683
DomainANK_REP_REGION

AGAP5 CTTNBP2 ANKLE1 HACE1 ANKRD24 AGAP7P AGAP4 AGAP6

1.00e-032541498PS50297
Domain-

RASA3 PLA2G4E MCTP1 PLA2G4B PLCG2 WWC1

1.21e-0314814962.60.40.150
DomainAnkyrin_rpt

AGAP5 CTTNBP2 ANKLE1 HACE1 ANKRD24 AGAP7P AGAP4 AGAP6

1.22e-032621498IPR002110
DomainPLA2_B

PLA2G4E PLA2G4B

1.29e-0371492PF01735
DomainPLA2C

PLA2G4E PLA2G4B

1.29e-0371492PS51210
DomainLysoPLipase_cat_dom

PLA2G4E PLA2G4B

1.29e-0371492IPR002642
DomainPLAc

PLA2G4E PLA2G4B

1.29e-0371492SM00022
DomainAnk_2

AGAP5 CTTNBP2 ANKLE1 HACE1 ANKRD24 AGAP4 AGAP6

1.72e-032151497PF12796
PathwayBIOCARTA_MRP_PATHWAY

ABCC1 ABCB1 ABCB4

8.36e-0661073M22078
Pubmed

GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.

AGAP5 AGAP7P AGAP4 AGAP6

4.58e-089154412640130
Pubmed

AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.

AGAP5 AGAP7P AGAP4 AGAP6

7.60e-0810154420664521
Pubmed

Transbilayer movement of NBD-labeled phospholipids in red blood cell membranes: outward-directed transport by the multidrug resistance protein 1 (MRP1).

ABCC1 ABCB1 ABCB4

8.51e-08315439778357
Pubmed

Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier.

ABCC1 ABCC4 ABCB1

8.51e-083154325986174
Pubmed

Immunolocalization of ABC drug transporters in human placenta from normal and gestational diabetic pregnancies.

ABCC1 ABCB1 ABCB4

8.51e-083154325029804
Pubmed

AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.

AGAP5 AGAP7P AGAP4 AGAP6

1.19e-0711154415381706
Pubmed

The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.

AGAP5 AGAP7P AGAP4 AGAP6

2.56e-0713154427713690
Pubmed

Glutamatergic Dysfunction and Synaptic Ultrastructural Alterations in Schizophrenia and Autism Spectrum Disorder: Evidence from Human and Rodent Studies.

CTTNBP2 VRK3 DIP2A MAPK8IP2

2.56e-0713154433374598
Pubmed

Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier.

ABCC1 ABCC4 ABCB1

3.39e-074154326507673
Pubmed

GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.

AGAP5 AGAP7P AGAP4 AGAP6

3.57e-0714154422453919
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

ABCC1 NCAPD3 TSC2 ARFGEF3 PTPN13 NF1 MDN1

4.31e-07104154731240132
Pubmed

Efflux protein expression in human stem cell-derived retinal pigment epithelial cells.

ABCC1 ABCC4 ABCB1

8.46e-075154322272278
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

TRERF1 TPR DIP2B NCAPD3 WAPL GCFC2 SRSF5 NUMA1 IQCN USP16 MYO3A NF1 MDN1 FUBP1 PLEC

2.00e-067741541515302935
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DIP2B ABCC4 RASA3 EVC CLASP2 IQCN TECTA ME2 DOCK5 OR51E2 ARFGEF3 ODF2L RIC8B HOXC4 PTPN13 FUBP1 PANK4 CACNA1H ANKRD24 NSMAF FRMD3

2.81e-0614891542128611215
Pubmed

Association of multi-drug resistance gene polymorphisms with pancreatic cancer outcome.

ABCC1 ABCC4 ABCB1

2.94e-067154320922799
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

DIP2B AGAP5 MAP4K3 TRIM56 AGAP7P AGAP4 AGAP6 WWC1

6.24e-06218154833378226
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PCSK5 USP34 RASA3 ARHGAP17 TSC2 CLASP2 ANKLE1 PLXND1 CTDSP2 DIP2A MDN1 CELSR2 PLA2G4B MTMR3 CACNA1H PLEC GAREM1

8.84e-0611051541735748872
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

NUMA1 TSC2 IPO4 ABCB1 FMNL3 ARFGEF3 PTPN13 NF1 LLGL1

1.17e-05313154938270169
Pubmed

Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation.

ABCC1 ABCC4 ABCB1

1.37e-0511154318619525
Pubmed

Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.

TECTA USH1C OTOG

1.37e-0511154331776257
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

NWD1 WAPL NUMA1 TOGARAM2 CLASP2 SPATA31A6 RYR3 DIP2A MDN1 KIF19 ANAPC4

1.46e-054971541136774506
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

TPR DIP2B NCAPD3 WAPL HK2 NUMA1 MDN1 SUPT5H PLEC

1.86e-05332154932786267
Pubmed

Use of a peptide mimotope to guide the humanization of MRK-16, an anti-P-glycoprotein monoclonal antibody.

ABCB1 ABCB4

1.95e-052154210488067
Pubmed

Membrane expression of MRP-1, but not MRP-1 splicing or Pgp expression, predicts survival in patients with ESFT.

ABCC1 ABCB1

1.95e-052154223799853
Pubmed

Multidrug resistance gene expression and ABCB1 SNPs in plasma cell myeloma.

ABCB1 ABCB4

1.95e-052154221705081
Pubmed

The role of different P-glycoproteins in hepatobiliary secretion of fluorescently labeled short-chain phospholipids.

ABCB1 ABCB4

1.95e-052154210552998
Pubmed

Differential Coupling of Binding, ATP Hydrolysis, and Transport of Fluorescent Probes with P-Glycoprotein in Lipid Nanodiscs.

ABCB1 ABCB4

1.95e-052154228441502
Pubmed

Genetic dissection of the function of mammalian P-glycoproteins.

ABCB1 ABCB4

1.95e-05215429196326
Pubmed

ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment.

ABCC1 ABCB1

1.95e-052154218851956
Pubmed

Effects of cellular, chemical, and pharmacological chaperones on the rescue of a trafficking-defective mutant of the ATP-binding cassette transporter proteins ABCB1/ABCB4.

ABCB1 ABCB4

1.95e-052154222184139
Pubmed

Evaluation of multidrug resistance in 46 newly diagnosed patients with acute leukemia.

ABCC1 ABCB1

1.95e-052154222664042
Pubmed

Isolation and expression of a complementary DNA that confers multidrug resistance.

ABCB1 ABCB4

1.95e-05215423022150
Pubmed

Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces.

ABCC1 ABCB1

1.95e-052154218680196
Pubmed

A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity.

HK2 GCK

1.95e-052154233594203
Pubmed

Mammalian multidrug-resistance gene: correlation of exon organization with structural domains and duplication of an ancestral gene.

ABCB1 ABCB4

1.95e-05215422570420
Pubmed

Expression and function of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in lung dendritic cells from aging mice.

ABCC1 ABCB1

1.95e-052154222451472
Pubmed

The pharmacological phenotype of combined multidrug-resistance mdr1a/1b- and mrp1-deficient mice.

ABCC1 ABCB1

1.95e-052154211245453
Pubmed

Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma.

ABCC1 ABCC4

1.95e-052154224024181
Pubmed

MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.

ABCB1 ABCB4

1.95e-05215428898203
Pubmed

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. Evidence that distinct P-glycoprotein precursors are encoded by unique mdr genes.

ABCB1 ABCB4

1.95e-05215422473069
Pubmed

Common genetic variation and risk of gallbladder cancer in India: a case-control genome-wide association study.

ABCB1 ABCB4

1.95e-052154228274756
Pubmed

MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation.

MAP4K3 GCK

1.95e-052154235966593
Pubmed

Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary.

ABCC1 ABCB1

1.95e-052154225218792
Pubmed

Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance.

ABCC1 ABCB1

1.95e-052154217852453
Pubmed

A missense mutation in ABCB4 gene involved in progressive familial intrahepatic cholestasis type 3 leads to a folding defect that can be rescued by low temperature.

ABCB1 ABCB4

1.95e-052154219185004
Pubmed

Nuclear multidrug-resistance related protein 1 contributes to multidrug-resistance of mucoepidermoid carcinoma mainly via regulating multidrug-resistance protein 1: a human mucoepidermoid carcinoma cells model and Spearman's rank correlation analysis.

ABCC1 ABCB1

1.95e-052154224013781
Pubmed

Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression.

ABCB1 ABCB4

1.95e-052154218215618
Pubmed

Role of ABCB1 and ABCC1 gene induction on survival in locally advanced breast cancer.

ABCC1 ABCB1

1.95e-052154219129072
Pubmed

Impact of the Motor and Tail Domains of Class III Myosins on Regulating the Formation and Elongation of Actin Protrusions.

MYO3A MYO3B

1.95e-052154227582493
Pubmed

Genetic susceptibility of lung cancer associated with common variants in the 3' untranslated regions of the adenosine triphosphate-binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export.

ABCC1 ABCB1

1.95e-052154219107762
Pubmed

Association of ABCB1 and FLT3 Polymorphisms with Toxicities and Survival in Asian Patients Receiving Sunitinib for Renal Cell Carcinoma.

FLT3 ABCB1

1.95e-052154226244574
Pubmed

Multidrug resistance in locally advanced breast cancer.

ABCC1 ABCB1

1.95e-052154217033200
Pubmed

The double face of the histone variant H3.3.

H3Y1 H3Y2

1.95e-052154221263457
Pubmed

Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines.

ABCC1 ABCC4

1.95e-052154233081264
Pubmed

What have we learnt thus far from mice with disrupted P-glycoprotein genes?

ABCB1 ABCB4

1.95e-05215428763339
Pubmed

Mice lacking the multidrug resistance protein 1 have a transiently impaired immune response during tuberculosis.

ABCC1 ABCB1

1.95e-052154212296850
Pubmed

Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma.

ABCC1 ABCB1

1.95e-052154219552816
Pubmed

Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers.

ABCC1 ABCB1

1.95e-052154223168528
Pubmed

Gangliosides do not affect ABC transporter function in human neuroblastoma cells.

ABCC1 ABCB1

1.95e-052154216547352
Pubmed

Negative impact of FLT3-ITD mutation on expression of MDR-1 mRNA in adult acute myeloid leukemia.

FLT3 ABCB1

1.95e-052154222591177
Pubmed

Biliary secretion of alpha-tocopherol and the role of the mdr2 P-glycoprotein in rats and mice.

ABCB1 ABCB4

1.95e-05215429473291
Pubmed

Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y.

H3Y1 H3Y2

1.95e-052154220819935
Pubmed

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

ABCB1 ABCB4

1.95e-05215422471060
Pubmed

Mouse class III myosins: kinase activity and phosphorylation sites.

MYO3A MYO3B

1.95e-052154221895655
Pubmed

MDR1 and MDR3 genes and drug resistance to cisplatin of ovarian cancer cells.

ABCB1 ABCB4

1.95e-052154218231753
Pubmed

Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes.

ABCC1 ABCB1

1.95e-052154215328029
Pubmed

The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action.

ABCC1 ABCB1

1.95e-052154236221036
Pubmed

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier.

ABCC1 ABCB1

1.95e-052154210675353
Pubmed

ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans.

ABCB1 ABCB4

1.95e-052154232058310
Pubmed

Variation of MDR proteins expression and activity levels according to clinical status and evolution of CML patients.

ABCC1 ABCB1

1.95e-052154221520403
Pubmed

Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium.

ABCC1 ABCB1

1.95e-052154222563480
Pubmed

Polymorphisms in the multiple drug resistance protein 1 and in P-glycoprotein 1 are associated with time to event outcomes in patients with advanced multiple myeloma treated with bortezomib and pegylated liposomal doxorubicin.

ABCC1 ABCB1

1.95e-052154220532504
Pubmed

MDR-1 and MRP-1 activity in peripheral blood leukocytes of rheumatoid arthritis patients.

ABCC1 ABCB1

1.95e-052154226715450
Pubmed

P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice.

ABCC4 ABCB1

1.95e-052154220583968
Pubmed

Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy.

ABCC1 ABCB1

1.95e-052154214984901
Pubmed

ABCB1 and ABCC1 variants associated with virological failure of first-line protease inhibitors antiretroviral regimens in Northeast Brazil patients.

ABCC1 ABCB1

1.95e-052154223996099
Pubmed

Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins.

ABCB1 ABCB4

1.95e-05215423768958
Pubmed

Nucleotide triphosphatase activity of the N-terminal nucleotide-binding domains of the multidrug resistance proteins P-glycoprotein and MRP1.

ABCC1 ABCB1

1.95e-052154212163030
Pubmed

Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice.

ABCB1 ABCB4

1.95e-052154238522903
Pubmed

Localization of the human multiple drug resistance gene, MDR1, to 7q21.1.

ABCB1 ABCB4

1.95e-05215423477522
Pubmed

Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice.

ABCC4 ABCB1

1.95e-052154216988054
Pubmed

Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis.

ABCC1 ABCB1

1.95e-052154220234362
Pubmed

Decreased functional activity of multidrug resistance protein in primary colorectal cancer.

ABCC1 ABCB1

1.95e-052154225885226
Pubmed

Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study.

ABCB1 ABCB4

1.95e-052154216857572
Pubmed

Expressions of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in lung dendritic cells.

ABCC1 ABCB1

1.95e-052154221763326
Pubmed

Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells.

ABCB1 ABCB4

1.95e-05215421969609
Pubmed

Expression of MDR1 and MDR3 gene products in paclitaxel-, doxorubicin- and vincristine-resistant cell lines.

ABCB1 ABCB4

1.95e-052154224140176
Pubmed

Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis.

ABCB1 ABCB4

1.95e-05215429419367
Pubmed

Expression of the multidrug resistance P glycoprotein (Pgp) and multidrug resistance associated protein (MRP1) in Down syndrome brains.

ABCC1 ABCB1

1.95e-052154211771758
Pubmed

Cell-specific activity of cis-acting regulatory elements in the promoter of the mouse multidrug resistance gene mdr1.

ABCB1 ABCB4

1.95e-05215422248681
Pubmed

Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice.

ABCC1 ABCB1

1.95e-052154217617921
Pubmed

The role of multiple drug resistance proteins in fetal and/or placental protection against teratogen-induced orofacial clefting.

ABCB1 ABCB4

1.95e-052154217440929
Pubmed

Clinicopathological parameters and expression of P-glycoprotein and MRP-1 in retinoblastoma.

ABCC1 ABCB1

1.95e-052154217596751
Pubmed

Amplification of the murine mdr2 gene and a reconsideration of the structure of the murine mdr gene locus.

ABCB1 ABCB4

1.95e-05215427832992
Pubmed

Impact of ABCB1 single nucleotide polymorphisms 1236C>T and 2677G>T on overall survival in FLT3 wild-type de novo AML patients with normal karyotype.

FLT3 ABCB1

1.95e-052154225155901
Pubmed

Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1.

ABCC1 ABCB1

1.95e-052154218280247
Pubmed

Mdr P-glycoproteins are not essential for biliary excretion of the hydrophobic heme precursor protoporphyrin in a griseofulvin-induced mouse model of erythropoietic protoporphyria.

ABCB1 ABCB4

1.95e-052154211826402
Pubmed

Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis.

ABCC1 ABCC4

1.95e-052154224130369
Pubmed

Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1.

ABCC1 ABCB1

1.95e-052154212084474
Pubmed

Expression of P-glycoprotein and multidrug resistance-associated protein is associated with multidrug resistance in gastric cancer.

ABCC1 ABCB1

1.95e-052154220233511
GeneFamilyMyosins, class III|Deafness associated genes

MYO3A MYO3B

3.03e-05210021099
GeneFamilyArfGAPs

AGAP5 AGAP7P AGAP4 AGAP6

3.19e-05331004395
GeneFamilyAnkyrin repeat domain containing

AGAP5 CTTNBP2 ANKLE1 HACE1 ANKRD24 AGAP7P AGAP4 AGAP6

5.92e-052421008403
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

AGAP5 AGAP4 AGAP6

1.06e-041710031291
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLA2G4E PLA2G4B PLCG2

1.49e-04191003832
GeneFamilyMitogen-activated protein kinase kinase kinase kinases

MAP4K3 MAP4K2

3.00e-0451002655
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

AGAP5 RASA3 PLEKHA4 AGAP7P AGAP4 AGAP6

9.97e-042061006682
GeneFamilyPhospholipases

PLA2G4E PLA2G4B PLCG2

1.61e-03421003467
GeneFamilyATP binding cassette subfamily B

ABCB1 ABCB4

1.61e-03111002806
GeneFamilyATP binding cassette subfamily C

ABCC1 ABCC4

2.27e-03131002807
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

TSC2 RB1CC1 PREX2 ARFGEF3 WWC1

3.33e-031811005694
CoexpressionHE_LIM_SUN_FETAL_LUNG_C3_GRIA2_POS_ARTERIAL_ENDO_CELL

PCSK5 ABCC4 COL15A1 PREX2 LTBP1 ATP13A3 PLCG2

4.57e-061151507M45752
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

NPHS1 CTTNBP2 EVC USH1C ABCB1 MYO3A PKHD1 WWC1

1.25e-071681538a086c306be430adf0632ba53e98cd8014d2de330
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 TECTA RYR3 ABCB1 DIP2A MCTP1 CRYBG3 FRMD3

1.86e-0717715384c069f0d044a96118090b85ca592a21d6b5d9399
ToppCellControl-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

PCSK5 ABCC4 PREX2 SRPX2 MCTP1 HEY2 LTBP1 ATP13A3

3.47e-0719215387e89b9125e8b85f6be85eeccef5c8644647ab0e1
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 PLXND1 PREX2 MCTP1 HEY2 ATP13A3 CRYBG3 PLEC

4.72e-07200153893e13937ec74418a697c37d56f57509fb2154780
ToppCellCiliated_cells-B-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

CHST5 NWD1 TOGARAM2 FAM81A RYR3 KIF19 CFAP206

1.63e-0616415370e9961acbb1d6c0089e6805ba6756736fa4d8bed
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPY2R GRIK4 RYR3 ABCB1 MCTP1 CRYBG3 FRMD3

2.33e-06173153795c723b09254ae7131fe5ba0841472502e83269b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK4 TECTA RYR3 ABCB1 DIP2A MCTP1 CRYBG3

3.14e-06181153708f44323bf71b6004a921bbc969c954c75feeb66
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 PLXND1 PREX2 MCTP1 TSPAN7 ATP13A3 FRMD3

4.03e-0618815375bc1537e079c7435196c163bff5f639ea392a33a
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 CTTNBP2 PLXND1 MCTP1 TSPAN7 ATP13A3 FRMD3

4.17e-0618915379da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 CTTNBP2 PLXND1 MCTP1 TSPAN7 ATP13A3 FRMD3

4.47e-0619115373307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CASR GCNT2 PTPN13 MYO3B PKHD1 WWC1 GAREM1

5.12e-0619515376477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 MCTP1 TSPAN7 LTBP1 ATP13A3 CRYBG3 PLEC

5.66e-0619815375e781583908c4ee107d986904a646a7c6b8e3591
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-OPC_related|GW16 / Sample Type, Dataset, Time_group, and Cell type.

NPHS1 IQCN DDC TRMT10A KIF19 PLEC

9.80e-061421536d2d150e3019a5b7b143e50b1c1c2b6764abf36bf
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-OPC_related-Oligodendrocyte/OPC|GW16 / Sample Type, Dataset, Time_group, and Cell type.

NPHS1 IQCN DDC TRMT10A KIF19 PLEC

9.80e-06142153643e72e4b9ae33768672ef90c8bbfd2ca1818c746
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Hematologic-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT3 NLRC4 PLA2G4B TLR2 STAG3 PIF1

1.24e-0514815367c7c87b57aa16f8b91698489df39ace5a3a53df8
ToppCellCOVID-19-Mast_cells-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

ABCC4 CTTNBP2 ENTHD1 RYR3 OSBPL6 CACNA1H

1.67e-051561536bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCellCOVID-19-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

ABCC4 CTTNBP2 ENTHD1 RYR3 OSBPL6 CACNA1H

1.67e-051561536159504d43421ee83b9ab484816333ae549c9c2fd
ToppCell5'-Adult-Appendix-Hematopoietic-T_cells-TRGV5/7_gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NWD1 GPR19 TOGARAM2 CELSR2 CD101 PIF1

1.86e-051591536006076bac619bf14a4c98f1158ac336bd9908914
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 ZNF596 TOGARAM2 RYR3 TCEANC2 UNC80

1.86e-051591536fd7db2f7328cfefdc3ada2af91006d5a91d137e1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 ZNF596 TOGARAM2 RYR3 TCEANC2 UNC80

1.86e-051591536aaf449c768d6fbb0a1bb47746ff3bdb7f9eb8914
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 ZNF596 TOGARAM2 RYR3 TCEANC2 UNC80

1.86e-0515915368bbdef1e927f3130b578d7d7c5ff38bbe06fab63
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Shisa8_(Layer_5,_medial_posterior_cortex_(Retrosplenial_cortex_(RSG),_subiculum))-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SLC6A16 ITPRID1 USH1C OTOG

2.42e-054915343eca54d2c8426e6d78a4a3b261f9a5ad786515a3
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Shisa8_(Layer_5,_medial_posterior_cortex_(Retrosplenial_cortex_(RSG),_subiculum))|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SLC6A16 ITPRID1 USH1C OTOG

2.42e-054915347ea79acc4a7210c32181d4b306b07fe35f598dae
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 GRIK4 RYR3 ABCB1 MCTP1 FRMD3

2.54e-0516815367abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCelldroplet-Lung-nan-18m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRERF1 FLT3 CLTRN MCTP1 GRIFIN NSMAF

2.63e-051691536149a4f83da15bdeb170e980fb5b5b1af89ae07a6
ToppCelldroplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TRERF1 FLT3 HK2 CLTRN MCTP1 GRIFIN

2.72e-051701536bf589c4297ccc90e5f51e3d0fcc229548af4fcef
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHST5 CASR DDC ARFGEF3 KIF19 PLCG2

3.09e-0517415363503c7dec498597f76a86dbd5e4bb2311e743bde
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK4 TECTA RYR3 ABCB1 MCTP1 CRYBG3

3.30e-05176153672a2a01618ce836bc843395d5095e9090759b4a6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 CTTNBP2 EVC PKHD1 WWC1 FRMD3

3.51e-051781536c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 CTTNBP2 TOGARAM2 RYR3 DOCK5 FRMD3

3.63e-0517915367394e77e665bf16d3733df91bb12907be460ab44
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|368C / Donor, Lineage, Cell class and subclass (all cells)

MAP4K3 PRUNE1 HOXC4 LLGL1 KIF19 TRMT5

3.63e-05179153610c7d371937d9d93c12c8d3465430ef9e0c2ec81
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 GRIK4 RYR3 ABCB1 MCTP1 CRYBG3

3.74e-051801536b514c55e52b46e8a1a2f09ed2c59a7683367a505
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CTTNBP2 USH1C ABCB1 PKHD1 WWC1 FRMD3

3.86e-0518115366956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CASR USH1C ABCB1 MYO3B PKHD1 WWC1

3.98e-0518215369d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCellfacs-Lung-nan-3m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 PLXND1 MCTP1 HEY2 ATP13A3 FRMD3

4.10e-05183153612e876d6205af8aad74265c668b5e95b9e7487f3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPHS1 CTTNBP2 TOGARAM2 RYR3 DOCK5 FRMD3

4.10e-051831536848fc6dd129150897ee339343e83c645b6e779eb
ToppCellCOVID-19-kidney-PCT-S1|kidney / Disease (COVID-19 only), tissue and cell type

ABCC4 CLTRN USH1C VPS13A PKHD1 WWC1

4.23e-05184153651ed1ebfdef45149541917c66cbacad87072e51f
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

VRK3 POT1 KIAA1586 NMD3 TRIM56 PLEC

4.23e-051841536e6bf826be31e1723e24c366fc5a1cee9b15589bc
ToppCellIPF-Myeloid-Mast|World / Disease state, Lineage and Cell class

ABCC1 ABCC4 CTTNBP2 FMNL3 OSBPL6 CACNA1H

4.23e-0518415367aefa182acad5a53c730945fec85329d7168606a
ToppCellCOPD-Myeloid-Mast|COPD / Disease state, Lineage and Cell class

ABCC4 CTTNBP2 RYR3 FMNL3 OSBPL6 CACNA1H

4.49e-051861536def6f0f284acc2154738574c8c5d3d2a5ef1f208
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

USH1C DDC ARFGEF3 KIF19 UNC80 MAPK8IP2

4.49e-051861536c7983281a290201567b398e9ea6baddb96c692bb
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-2|TCGA-Kidney / Sample_Type by Project: Shred V9

COL15A1 PLXND1 PREX2 FMNL3 OR51E2 ACAN

4.49e-0518615361e6526fc9e9381b7ace864588cc7bd80194338d6
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

CLTRN CASR USH1C MYO3B PKHD1 WWC1

4.63e-051871536d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAP4K3 FAM81A PTPN13 MCTP1 MYO3B LTBP1

4.63e-051871536f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCellCOPD-Lymphoid-NK|COPD / Disease state, Lineage and Cell class

TRERF1 RASA3 GRIK4 ABCB1 DIP2A PLCG2

4.77e-051881536c9a227c8e71b69929d43e9afb8306a95c8163778
ToppCellfacs-Tongue-nan-24m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2G4E FAM81A TENT5B CELSR2 SLURP2 TLCD3A

4.77e-051881536ed35e438796cef302b6787c111753425922792dc
ToppCellCOVID-19-kidney-CD-PC|COVID-19 / Disease (COVID-19 only), tissue and cell type

FAM81A PTPN13 MYO3B PKHD1 WWC1 GAREM1

4.77e-0518815368f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

GCNT2 ARFGEF3 MYO3B VPS13A PKHD1 FRMD3

4.77e-051881536beb2df2332a46cc81b10e8e29fc9829020111f03
ToppCellCOPD-Lymphoid-NK|World / Disease state, Lineage and Cell class

TRERF1 RASA3 GRIK4 ABCB1 DIP2A PLCG2

4.91e-051891536c0ac160fa7e68b92414fb1600abcac8ad1a42232
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 USH1C ABCB1 MYO3A PKHD1 WWC1

4.91e-0518915363b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

AGAP5 PLXND1 MCTP1 TLR2 CRYBG3 TRMT5

4.91e-051891536a2f4f1dd5452f7efb7427919a0b90875cf2e1dc7
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

GCNT2 ARFGEF3 MYO3B PKHD1 WWC1 FRMD3

4.91e-0518915367659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AGAP5 PLXND1 MCTP1 TLR2 CRYBG3 TRMT5

4.91e-05189153654a45b0cb7dea01caf1cf0a2664c40e5779a0b61
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 USH1C ABCB1 MYO3A PKHD1 WWC1

4.91e-05189153628b502611829e4a24caff2562545c7db97686099
ToppCellCOVID-19-kidney-PCT-S2|kidney / Disease (COVID-19 only), tissue and cell type

PCSK5 ABCC4 CLTRN USH1C PKHD1 WWC1

4.91e-0518915360be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCellEndothelial-A-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

COL15A1 CASR PREX2 ABCB1 TSPAN7 LTBP1

5.20e-051911536f702dfe88a9b04091dae87df61b2b4f43525f86a
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 PREX2 ABCB1 MCTP1 TSPAN7 CRYBG3

5.20e-05191153604c7aa2e39fdd08ca24c10d43b29a5e41a73b9e0
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 PLXND1 PREX2 MCTP1 TSPAN7 LTBP1

5.20e-051911536b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 PREX2 ABCB1 MCTP1 TSPAN7 CRYBG3

5.20e-051911536db8dd6bbba803585bdd6a55d5c403d383f2e9acf
ToppCellP07-Endothelial-large_vessel_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 PLXND1 MCTP1 TSPAN7 ATP13A3 PLEC

5.20e-051911536d162917816dd2e4767c97447c1cddae9397713ab
ToppCellIPF-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

PCSK5 ABCC4 SRPX2 HEY2 LTBP1 ATP13A3

5.36e-051921536e911e286da26202853f9650ba3cdefe5a5c9b585
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 PREX2 ABCB1 MCTP1 TSPAN7 CRYBG3

5.51e-0519315363a9fe4e709c09ec787c71bdd6b58a71c419896de
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

USH1C DDC ARFGEF3 KIF19 CACNA1H MAPK8IP2

5.51e-0519315368603d1a38955ad2529d04e4704467c73ea5bfbda
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLXND1 PREX2 RYR3 MCTP1 HEY2 ATP13A3

5.51e-0519315360b328f725f6feba263783eaca60c142e80df90f3
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPR USP34 WAPL RB1CC1 PREX2 SAMD9L

5.67e-051941536e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 EVC CASR PKHD1 WWC1 GAREM1

5.67e-051941536e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EVC PTPN13 MYO3B PKHD1 WWC1 GAREM1

5.67e-05194153693c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CASR PTPN13 MYO3B PKHD1 WWC1 GAREM1

5.67e-0519415365eaaa81f4b2535f983c424aaef00077089526a5c
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

GCNT2 ARFGEF3 MYO3B PKHD1 WWC1 FRMD3

5.67e-051941536f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTTNBP2 DDC ARFGEF3 ST8SIA5 UNC80 MAPK8IP2

5.84e-051951536bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DDC ARFGEF3 KIF19 CACNA1H UNC80 MAPK8IP2

5.84e-0519515365f33ece997f074598b4201ff74f592ee07c86a06
ToppCelldroplet-Bladder-nan-24m-Endothelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 FAM81A FMNL3 HEY2 CACNA1H LTBP1

6.01e-0519615369a90dd26e7a43e3fd55e7c5d8354cfa4cdd5a6cc
ToppCellCOVID-19-kidney-TAL|kidney / Disease (COVID-19 only), tissue and cell type

CASR ARFGEF3 MYO3B TLR2 PKHD1 CACNA1H

6.01e-05196153604f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCelldroplet-Bladder-nan-24m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 FAM81A FMNL3 HEY2 CACNA1H LTBP1

6.01e-05196153604dfef1bd4ebb0e9469ae80024dc177e469a2560
ToppCell(4)_Blood_vessel|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

COL15A1 PLXND1 PREX2 ABCB1 MCTP1 TSPAN7

6.18e-0519715361b82979a41ef46c814c82527a585900586d71260
ToppCellTracheal-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRERF1 ABCC4 CTTNBP2 MCTP1 OSBPL6 PLCG2

6.35e-051981536cc5ca64749e2f4f1d373d9472824df85741702b7
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABCC4 ARFGEF3 PTPN13 TLR2 WWC1 GAREM1

6.35e-051981536f948391296c261c473d339069a6d0f20ccd6f38f
ToppCellTracheal-NucSeq-Immune_Myeloid-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRERF1 ABCC4 CTTNBP2 MCTP1 OSBPL6 PLCG2

6.35e-051981536d4d66f19df078bfc3a83d4664aaf9c7789bde1a5
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABCC4 ARFGEF3 PTPN13 TLR2 WWC1 GAREM1

6.35e-0519815362e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell(7)_Epithelial_cells-(7)_Epithelial-A_(AT2)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

ABCC4 HK2 GCK IQCN PTPN13 MCTP1

6.53e-05199153609cf004032e5af912ee0cdde6e24ce3bcf7673cd
ToppCellParenchymal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GCNT2 DOCK5 ARFGEF3 PTPN13 WWC1 GAREM1

6.53e-0519915365cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCellTracheal-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD14|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FLT3 PLXND1 DDC MCTP1 TLR2 PIK3R5

6.53e-0519915361413156b7be5373fd02bbe39ec50ccfe165fa6d1
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Mesenchymal-Mesoderm|10w / Sample Type, Dataset, Time_group, and Cell type.

NPHS1 ABCC4 CLTRN SNX19 ABCB1 TRIM56

6.71e-0520015369ef226ebb0a7cdb9431e2fa65faa2a7d67da590d
ToppCellmild-HLA-DR+_CD83+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SIRPB1 DOCK5 MCTP1 TLR2 PLCG2 PLEC

6.71e-052001536934c2efc780318c66d667ca75be0de350361d351
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Col8a1_Rprm|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCSK5 RYR3 SAMD9L SRPX2 MCTP1

9.31e-05132153566ec5a06eece27c0aafb548f51db9fee595e71bc
ToppCellCOVID-19_Mild-Neu_2|World / 5 Neutrophil clusters in COVID-19 patients

ARFGEF3 MYO3A PRMT9 CFAP206 UNC80

1.23e-041401535b1429028c52f84127b894b93b55961badcd5246f
ToppCell(08)_PNEC-(2)_48hpi|(08)_PNEC / shred by cell type and Timepoint

CTTNBP2 PIPOX PLXND1 MPPE1 FRMD3

1.31e-041421535e95d34170f5053678e0dd9793e68d93c03b05822
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ARFGEF3 MYO3A PRMT9 CFAP206 UNC80

1.36e-0414315359836a040a2ebcf6f05431e658a7b8fd566621452
ToppCellPBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ARFGEF3 MYO3A PRMT9 CFAP206 UNC80

1.36e-0414315354622c221b5d2d4cd4f37e4f81662e073924e1507
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NPY2R GRIK4 TECTA HOXC4 CACNA1H

1.45e-04145153578f5f4b96420c7f391e4d32a9ed151ed95fad90b
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_bronchial_vessel|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL15A1 PREX2 ABCB1 MCTP1 CD101

1.49e-041461535df865558d1843f3857ebd1529cebc540d3554c59
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8|TCGA-Bladder / Sample_Type by Project: Shred V9

TRERF1 MAP4K3 NMD3 ARFGEF3 PLA2G4B

1.64e-04149153589705865e94360c1288ee98c5a6b381f3c6242b3
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage|368C / Donor, Lineage, Cell class and subclass (all cells)

NLRC4 HOXB7 SAMD9L CD101 CFAP206

1.86e-041531535e0fbbfd4d13031412e0b985322c8b99c56eb7af5
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

HOXB7 CD101 CFAP206 FRMD3 TANGO6

1.86e-0415315359f0607a88d5f8a2c128a2ff64dfbc986212f13b2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TOGARAM2 GRIK4 PLXND1 SRPX2 CELSR2

2.22e-041591535330ecbba97d47bc818a5e8d1d84b05d056bd831e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TOGARAM2 GRIK4 PLXND1 SRPX2 CELSR2

2.22e-041591535cbb331eb689d8cea9e1146ba85e0a05d23301c47
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTTNBP2 TECTA RYR3 PKHD1 UNC80

2.29e-041601535c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTTNBP2 TECTA RYR3 PKHD1 UNC80

2.29e-04160153525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PCSK5 PREX2 TSPAN7 HEY2 MAP4K2

2.42e-04162153525bb1b9709f960fdf90faff56e874f52a8f5d17e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CASR IQCN RYR3 MYO3B GAREM1

2.42e-041621535373513f9d0e5007b2e10a8b78d4909dcce9e3b62
DrugTechnetium Tc 99m Sestamibi

ABCC1 ABCB1 ABCB4

2.80e-0731503ctd:D017256
DrugAC1NE3ZR

PCSK5 ABCC1 ABCC4 CTTNBP2 ABCB1

6.83e-07261505CID004636208
Drug8-azidoadenosine 5'-triphosphate

ABCC1 ABCC4 ABCB1

1.12e-0641503ctd:C017040
DrugMefloquine

ABCC1 ABCC4 ABCB1

5.52e-0661503ctd:D015767
DrugNorethynodrel [68-23-5]; Down 200; 13.4uM; HL60; HT_HG-U133A

ABCC4 FLT3 GCFC2 PLXND1 NF1 ENTPD6 VPS13A ATP13A3 PIK3R5

5.56e-0619315091860_DN
DrugNSC638615

ABCC1 ABCC4 HK2 GCK PLXND1 ABCB1 ABCB4

7.04e-061071507CID000097535
Drugestradiol-17 beta-glucuronide

ABCC1 ABCC4 ABCB1 ABCB4

1.21e-05221504ctd:C025483
DrugGW3965

GCK ABCB1 ABCB4 TLR2 PLEC

1.42e-05471505CID000447905
Drugcalcein AM

ABCC1 ABCC4 ABCB1

1.53e-0581503ctd:C085925
Drugnicotine glucuronide

ABCC1 ABCB1 ABCB4

1.53e-0581503CID003035848
DrugtXMP

ABCC4 ABCB1 ABCB4

1.53e-0581503CID003081384
DrugNSC226080

TRERF1 PCSK5 TPR HK2 MAP4K3 PSMA7 TSC2 RB1CC1 PREX2 RYR3 ABCB1 DOCK5 MYO3A NF1 ACAN MYO3B PIK3R5

1.64e-0578215017CID000005040
DrugSo324

ABCC4 ABCB1 ABCB4

2.29e-0591503CID000462261
DrugCMPD167

ABCC1 RB1CC1 ABCB1

2.29e-0591503CID005481119
DrugAC-759

ABCC1 ABCC4 HK2 CASR ABCB1 ABCB4

2.57e-05881506CID000005396
DrugAC1NN9F1

ABCC1 ABCB1 ABCB4

3.25e-05101503CID000000410
Drug1,9-dideoxyforskolin

ABCB1 ABCB4

4.31e-0521502ctd:C047983
DrugNSC330500

TSC2 ABCB1

4.31e-0521502CID000433448
DrugAC1L9E0Q

ABCC1 ABCC4 ABCB1 ABCB4

4.34e-05301504CID000443095
DrugcarAa

CTTNBP2 CASR GRIK4

5.90e-05121503CID000166765
Diseasecerebral palsy (implicated_via_orthology)

AGAP5 AGAP7P AGAP4 AGAP6

1.32e-07101504DOID:1969 (implicated_via_orthology)
Diseasechronic widespread pain

DIP2B CASR PLCG2 AGAP7P

5.27e-06231504EFO_0010099
Diseasecystic fibrosis (implicated_via_orthology)

ABCC4 ABCB1 ABCB4

1.06e-0591503DOID:1485 (implicated_via_orthology)
Diseasehepatocellular carcinoma (is_implicated_in)

FLT3 POT1 RYR3 ABCB1 PTPN13 FUBP1 TLR2

4.09e-051811507DOID:684 (is_implicated_in)
DiseaseColorectal Carcinoma

ABCC1 ABCC4 ITPRID1 PREX2 ABCB1 ABCB4 NF1 TLR2 PANK4 VPS13A PKHD1 PIK3R5 ANAPC4

6.49e-0570215013C0009402
DiseaseDrug toxicity

ABCC1 ABCC4 ABCB1 TLR2 CACNA1H

7.10e-05841505C0013221
DiseaseAdverse reaction to drug

ABCC1 ABCC4 ABCB1 TLR2 CACNA1H

7.10e-05841505C0041755
DiseaseCryopyrin-Associated Periodic Syndromes

NLRC4 PLCG2

1.53e-0441502C2316212
DiseaseChronic Infantile Neurological, Cutaneous, and Articular Syndrome

NLRC4 PLCG2

1.53e-0441502C0409818
Diseasetriglyceride measurement, coronary artery disease

GCK MAP4K2

1.53e-0441502EFO_0001645, EFO_0004530
DiseaseFamilial Cold Autoinflammatory Syndrome 1

NLRC4 PLCG2

1.53e-0441502C4551895
DiseaseFamilial cold urticaria

NLRC4 PLCG2

1.53e-0441502C0343068
DiseaseFamilial cold autoinflammatory syndrome

NLRC4 PLCG2

1.53e-0441502cv:C0343068
DiseaseMuckle-Wells Syndrome

NLRC4 PLCG2

2.54e-0451502C0268390
Diseasejuvenile myelomonocytic leukemia (implicated_via_orthology)

FLT3 NF1

2.54e-0451502DOID:0050458 (implicated_via_orthology)
Diseasehyperinsulinemic hypoglycemia (implicated_via_orthology)

HK2 GCK

2.54e-0451502DOID:13317 (implicated_via_orthology)
Diseasemitochondrial myopathy (implicated_via_orthology)

COL15A1 TRMT5

3.80e-0461502DOID:699 (implicated_via_orthology)
Diseaseglucose metabolism disease (implicated_via_orthology)

HK2 GCK TRMT10A

3.84e-04281503DOID:4194 (implicated_via_orthology)
Diseasesmoking behavior, BMI-adjusted waist circumference

PCSK5 IQCN HOXC4 ACAN LTBP1

4.08e-041221505EFO_0004318, EFO_0007789
Diseaselaurylcarnitine measurement

ABCC1 ABCB1

5.30e-0471502EFO_0021041
Diseasefructosamine measurement

GCK MAP4K2

5.30e-0471502EFO_0009303
Diseasediastolic blood pressure, systolic blood pressure

GCK SNX19 DOCK5 ODF2L ACAN TRIM56 OSBPL6 MAP4K2 PIF1 NSMAF TANGO6

6.58e-0467015011EFO_0006335, EFO_0006336
Diseaseallergic rhinitis (is_implicated_in)

ABCB1 TLR2

7.04e-0481502DOID:4481 (is_implicated_in)
Diseasemean platelet volume

DIS3L NUMA1 CASR SIRPB1 PLXND1 ADH4 DOCK5 SRPX2 MICA LTBP1 ATP13A3 PLCG2 PLEC BRD1

7.33e-04102015014EFO_0004584
DiseaseNonsyndromic Deafness

TECTA USH1C MYO3A OTOG

7.88e-04811504C3711374
Diseaselung squamous cell carcinoma (is_marker_for)

PREX2 PTPN13 FUBP1

8.13e-04361503DOID:3907 (is_marker_for)
Diseasegallbladder neoplasm

ABCB1 ABCB4

9.03e-0491502EFO_0004606
Diseaseciliopathy (implicated_via_orthology)

MAP4K3 TOGARAM2 MAP4K2

1.11e-03401503DOID:0060340 (implicated_via_orthology)
Diseasematurity-onset diabetes of the young (implicated_via_orthology)

HK2 GCK

1.12e-03101502DOID:0050524 (implicated_via_orthology)
Diseasenucleus accumbens volume change measurement

ITPRID1 WWC1

1.37e-03111502EFO_0021493
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

DIP2B USP16 ABCB1 ABCB4 PLEC NSMAF

1.44e-032391506EFO_0010934
Diseasefibrinogen measurement, tissue plasminogen activator measurement

DIP2B PLXND1 PLEC

1.56e-03451503EFO_0004623, EFO_0004791
Diseasefibrinogen measurement, plasminogen activator inhibitor 1 measurement

DIP2B TRIM56 PLEC

1.56e-03451503EFO_0004623, EFO_0004792
DiseaseBehavior Disorders

DDC ABCB1

1.64e-03121502C0004930
DiseaseMental disorders

DDC ABCB1

1.64e-03121502C0004936
DiseaseMental Disorders, Severe

DDC ABCB1

1.64e-03121502C4046029
DiseaseDiagnosis, Psychiatric

DDC ABCB1

1.64e-03121502C0376338
Diseasesciatic neuropathy (biomarker_via_orthology)

PCSK5 NF1 FUBP1 CACNA1H

1.66e-03991504DOID:11446 (biomarker_via_orthology)
Diseaseend stage renal disease (biomarker_via_orthology)

NPHS1 DDC ABCB1

1.77e-03471503DOID:783 (biomarker_via_orthology)
DiseasePsychotic Disorders

GRIK4 ME2 ABCB1 WWC1

1.79e-031011504C0033975
Diseasepulse pressure measurement

USP34 DIP2B GPR19 COL15A1 PCDHA4 GCK SNX19 FMNL3 DIP2A ODF2L HOXB7 HOXC4 LTBP1 BRD1 MAP4K2 PIF1

1.98e-03139215016EFO_0005763
Diseasecholestasis (biomarker_via_orthology)

ABCC4 ABCB1 ABCB4

2.00e-03491503DOID:13580 (biomarker_via_orthology)
Diseaseneuritic plaque measurement

PCSK5 GRIK4 RYR3 MCTP1 HACE1 OSBPL6 PLCG2

2.12e-033491507EFO_0006798
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

TECTA USH1C MYO3A

2.24e-03511503cv:CN043650
DiseaseSquamous cell carcinoma of the head and neck

ABCC1 TSC2 ABCB1

2.37e-03521503C1168401
DiseaseCiliopathies

EVC TSC2 USH1C PKHD1

2.44e-031101504C4277690
Diseaseglycerate measurement

RYR3 MCTP1

2.58e-03151502EFO_0021029
Diseaseleft ventricular diastolic function measurement

FMNL3 MCTP1 GAREM1

2.64e-03541503EFO_0008204
DiseasePeripheral Nervous System Diseases

ABCC1 ABCB1 CACNA1H

2.64e-03541503C4721453
Diseasebody mass index, osteoarthritis

CACNA1H LTBP1 ANAPC4

2.64e-03541503EFO_0004340, MONDO_0005178
Diseasefactor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement

DIP2B ADH4 PLEC

2.93e-03561503EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
DiseaseIntrahepatic cholestasis of pregnancy

ABCB1 ABCB4

2.94e-03161502EFO_0009048
DiseasePheochromocytoma, Extra-Adrenal

DDC NF1

2.94e-03161502C1257877
Diseasefibrinogen measurement, factor VII measurement

DIP2B ADH4 PLEC

3.24e-03581503EFO_0004619, EFO_0004623
Diseaseserum metabolite measurement

ABCC1 ABCC4 GRIK4 GCK DDC ABCB4 ADH4 CELSR2 TRIM56 HEY2 PLCG2 MAP4K2

3.31e-0394515012EFO_0005653
Diseasehyperglycemia (implicated_via_orthology)

HK2 GCK

3.32e-03171502DOID:4195 (implicated_via_orthology)
Diseaseneuroimaging measurement, brain volume measurement

USP34 CTTNBP2 ITPRID1 NF1 HEY2 PLEC

3.52e-032861506EFO_0004346, EFO_0006930
Diseaseosteoarthritis, hip, osteoarthritis, knee

USP16 NF1 LTBP1

3.91e-03621503EFO_0004616, EFO_1000786
Diseaseresponse to methotrexate, juvenile idiopathic arthritis

CTTNBP2 ENTHD1

4.15e-03191502EFO_0002609, GO_0031427
Diseasekidney failure (biomarker_via_orthology)

NPHS1 TLR2

4.15e-03191502DOID:1074 (biomarker_via_orthology)
DiseasePheochromocytoma

DDC NF1

4.15e-03191502C0031511
Diseasehippocampal volume

ITPRID1 RYR3 HOXC4 PLEC WWC1 FRMD3

4.22e-032971506EFO_0005035
DiseaseAlcohol abuse

NPY2R ADH4 TLR2

4.86e-03671503C0085762
DiseaseHeadache, HbA1c measurement

PLXND1 ANAPC4

5.06e-03211502EFO_0004541, HP_0002315
Diseasevenous thromboembolism, plasminogen activator inhibitor 1 measurement

TRIM56 PLCG2

5.06e-03211502EFO_0004286, EFO_0004792

Protein segments in the cluster

PeptideGeneStartEntry
SISSCTHEEVINLIR

USH1C

141

Q9Y6N9
TDVVEIRRSNCTNHV

AGAP4

96

Q96P64
VRRHTLEDRSELISC

BRD1

881

O95696
SCVLSSNLRHVRVFE

ANAPC4

731

Q9UJX5
HLECARVLQDLDTRT

ANKLE1

121

Q8NAG6
RDELVSRSLQSAEHC

PRMT9

21

Q6P2P2
VLACERSESRTDLVH

CRYBG3

2036

Q68DQ2
EVRIQIIATSLCHTD

ADH4

36

P08319
THSTVRVSVCRVNEE

ATP13A3

266

Q9H7F0
RNTIEEVRCSTAAHA

CASR

866

P41180
EDTNLCAIHARRVTI

H3Y2

106

P0DPK5
VCLVIHRSRRTQSTT

GPR19

86

Q15760
VHSVTAQCALRVTII

CELSR2

1106

Q9HCU4
RERVCSVALSEHERI

ANKRD24

956

Q8TF21
LRFAICSRTVESAHV

DDC

446

P20711
TDVVEIRRSNCTNHV

AGAP6

96

Q5VW22
SVQTDLSHLRRENCS

CFAP206

556

Q8IYR0
RNIEATDHLTTELCL

NWD1

36

Q149M9
SLTAAERRLHECQES

ODF2L

471

Q9ULJ1
LRLSEVITDTGVVCH

RASA3

131

Q14644
CSLDVSHQVSTLVRR

QRICH2

1216

Q9H0J4
SVSLVEQLEDRILCH

FAM81A

26

Q8TBF8
LLTRTIRSTCLVHIE

IQCN

261

Q9H0B3
IVRRACESVSTRAAH

GCK

366

P35557
RCEQRLDAIHSEVSV

NPY2R

341

P49146
HCVSVLRAETLVTLD

LLGL1

321

Q15334
SSLQQEITILRECRH

MAP4K2

56

Q12851
IRVCEIHEDNSTRSS

MICA

116

Q29983
TCIVIAHRLSTIQNA

ABCB1

1226

P08183
HTSLNVQLERCRVVA

RB1CC1

791

Q8TDY2
VALQTTICEVLERSH

PRUNE1

306

Q86TP1
REVACRTRQRTSHSI

ENTHD1

141

Q8IYW4
VRLVSHLSTCATQRE

HEY2

151

Q9UBP5
VTCRAHSAELRETVS

NPHS1

621

O60500
VTHVTQLERDTILVC

MAP4K3

776

Q8IVH8
IRLSCIDSNHTEFII

OR10X1

201

Q8NGY0
CDILLALHTETRSTV

MDN1

2341

Q9NU22
RCQVDLSALSREQTH

MCTP1

551

Q6DN14
CVVELNNDRLLTHTV

MCTP1

651

Q6DN14
IVTTTTECLRHIRQF

NLRC4

276

Q9NPP4
LQDTTVRELCSCTVH

ITPRID1

851

Q6ZRS4
QKTLRVDVCTTDRSH

WWC1

741

Q8IX03
RCQHAAEIITDLLRS

FUBP1

331

Q96AE4
TVECLELRHRERTLN

GCNT2

376

Q8N0V5
DEHTQLELVSLRRCA

MAPK8IP2

516

Q13387
EDCVATHRICQIVST

HK2

366

P52789
EAELIEVSHRLNCSR

MPPE1

211

Q53F39
EDTNLCAIHARRVTI

H3Y1

106

P0DPK2
HVCVESTDRQIKTIR

PCSK5

466

Q92824
VNESVVRCDQVVLHT

PLXND1

801

Q9Y4D7
VRCDQVVLHTTRKSQ

PLXND1

806

Q9Y4D7
SCDIQIVSDRIIHCS

PLXND1

1221

Q9Y4D7
IVSDRIIHCSVNESL

PLXND1

1226

Q9Y4D7
IICTRVRNSLTIDHV

KIAA1586

716

Q9HCI6
DTLTATNFRVVICHL

LTBP1

391

Q14766
NCIVVFIVRTERSLH

OR51E2

41

Q9H255
RDELTQSFHRLSVCV

GAREM1

376

Q9H706
LVHRDSIFRSSCEVV

HACE1

556

Q8IYU2
TSVSRIHRSIAECAV

DIP2B

1481

Q9P265
RELEAQVHTIRILTC

GOLGA6L6

111

A8MZA4
LDIESERTVCHVAVQ

KBTBD7

231

Q8WVZ9
VSRTCLLTVRVLQAH

PLA2G4B

6

P0C869
VILSIEEHCSVEQQR

PLCG2

401

P16885
AVLCLTSLQVHRVAR

GPR78

186

Q96P69
LNRIHSESIICDQVV

OSBPL6

441

Q9BZF3
RRCREQQSHLSSIVT

ACAN

2346

P16112
RTCIVIAHRLSTIQN

ABCB4

1231

P21439
LTVRSLLDTREHCLN

PANK4

501

Q9NVE7
RRIEIAHTLCLTERQ

HOXB7

166

P09629
SEEQREVLSLLCRVH

KIF19

556

Q2TAC6
CTVLTIAHRLNTIID

ABCC4

1226

O15439
CRRSAECSIHLEVIV

PCDHA4

96

Q9UN74
VLVSRQVSCLEVHAQ

PLA2G4E

201

Q3MJ16
SCVHRDLAARNVLVT

FLT3

806

P36888
IRLLDDSEISCHIQR

FRMD3

36

A2A2Y4
TENVTEHREVAIRCS

CD101

821

Q93033
SIAIEEVTRCHIRFT

DOCK5

516

Q9H7D0
SQTTSLITHCRVILE

GCFC2

576

P16383
HTDCVRLLLSAEAQV

CTTNBP2

756

Q8WZ74
RICVVIDLDETLVHS

CTDSP2

101

O14595
VTVRISIQASRCHSD

DIS3L

951

Q8TF46
SIQASRCHSDTIRLE

DIS3L

956

Q8TF46
ELIRRECSIHDNSVL

FMNL3

856

Q8IVF7
ISQLTCHVTDIRVRQ

ARFGEF3

2146

Q5TH69
RIEIAHSLCLSERQI

HOXC4

186

P09017
TDVVEIRRSNCTNHV

AGAP7P

96

Q5VUJ5
LAVILCNTRHISDSV

ME2

476

P23368
VVETLLQLHRASCLD

NSMAF

146

Q92636
EECALSSVLQTHLRE

EVC

596

P57679
TSVIRAHRSIAECAV

DIP2A

1476

Q14689
TTRVRVLSDHCLAQV

GRIFIN

116

A4D1Z8
VTELRSIILCQDSIH

GRIK4

846

Q16099
RLLCRQEAVHTDSLE

CACNA1H

2011

O95180
EEVTLLVNCEEHSRI

COL15A1

171

P39059
TALQRETEHCVSLSL

IPO4

86

Q8TEX9
IESVECRDIFQLHLT

MTMR3

76

Q13615
VRTVLDACSAHIRNS

PTPN13

146

Q12923
QTCRHLTAQVRSLEA

NUMA1

1671

Q14980
LHTDLELSRERTCEQ

OTOG

896

Q6ZRI0
FEDCTVLTIAHRLNT

ABCC1

1476

P33527
VATRLCTHQDDVALT

PIF1

421

Q9H611
ISLEACSSVHLVRNV

TRMT5

441

Q32P41
LVENIERETFHLCSR

TCEANC2

151

Q96MN5
TVITHRCCERNAEIL

SLC6A16

401

Q9GZN6
LVSIQRLAACHSEVL

TOGARAM2

511

Q6ZUX3
SLHELCAARVSEVLQ

ENTPD6

351

O75354
VLSLLTECSRAHRNI

RIC8B

366

Q9NVN3
QIERRLDTVRSICHH

ARHGAP17

31

Q68EM7
SDLLRCTERTHIENI

SPATA31A6

711

Q5VVP1
VSVRATLCHLTQERE

PLEKHA4

431

Q9H4M7
CRSITVNDLTHLLEA

SAMD9L

1141

Q8IVG5
VERCQQLSATILTDH

POT1

326

Q9NUX5
IQVQALRRETHECSI

RNF32

281

Q9H0A6
NSTRCLELRHEILEV

ST8SIA5

56

O15466
VIVTCLRATAHALDT

PKHD1

2046

P08F94
LHSTCQTISVDRQRL

SUPT5H

736

O00267
VTICRIHETINATDE

SIX6OS1

46

Q8N1H7
ELCSERVTIEHARAR

SRSF5

61

Q13243
RVVETSALLCTAQHL

RIOX1

141

Q9H6W3
ACLVTLHRVVNESTV

TENT5B

341

Q96A09
LRDSTHCVTTATRVL

SLURP2

41

P0DP57
LTREDVHSQVICEVA

SIRPB1

216

Q5TFQ8
VVEIRRSNCTNHVST

AGAP5

121

A6NIR3
EVCRSHVRIAEAATL

CHST5

266

Q9GZS9
DVLSTCEHRLSNIVL

NCAPD3

826

P42695
QVVREACITVAHLST

CLASP2

151

O75122
ATEISHVLLCNVTQR

CLTRN

66

Q9HBJ8
LTRGDVHSQVICEIA

SIRPB1

216

O00241
IEENAVSLTCRFHVT

TECTA

2011

O75443
VVSTQLSHCRTILRL

PEX11G

51

Q96HA9
SVTHTREITLECRVC

ZNF596

186

Q8TC21
VRHRESGVERSIVCQ

VPS13A

1966

Q96RL7
HDISSRICDVALNIV

UNC80

666

Q8N2C7
QCRTVSLVHESFLDL

USP16

371

Q9Y5T5
ETLTRARQIDRSHCS

STAG3

911

Q9UJ98
TTCTEDRIQHALERC

PIK3R5

6

Q8WYR1
QSTCGLDLRHVTIIE

SRPX2

366

O60687
LSHSQERLVNETREC

TPR

61

P12270
RTEDEVVLQCIATIH

RYR3

16

Q15413
VSCLHILAQTLDTRT

RYR3

2926

Q15413
IVIIRSCDDVITGRH

TLCD3A

56

Q8TBR7
QSVSHIRSLCQEILL

TANGO6

491

Q9C0B7
AERCLRVLESVTVHN

WAPL

851

Q7Z5K2
ECEAIVQSIIHIRTR

NF1

1816

P21359
SALCSERIEHLCQRI

PREX2

886

Q70Z35
HVLSERSVLQVACRL

VRK3

276

Q8IV63
LQLEACETRTVHRLR

PLEC

1131

Q15149
TRTGRHVVVELITCN

SNX19

231

Q92543
VISVESLAQVHCLRS

THUMPD3

76

Q9BV44
SRQRVEHQCLSSEEL

PIPOX

111

Q9P0Z9
VVHSTLRLIIDCSFD

TRMT10A

96

Q8TBZ6
QHDILDTLCRTIEST

USP34

3516

Q70CQ2
DTLCRTIESTIHVVT

USP34

3521

Q70CQ2
VERASVSRNVVTHLC

WDR31

181

Q8NA23
QDVRLSVSECHRTAL

TLR2

576

O60603
ERSRAVDHVQRSLSC

TSPAN7

136

P41732
RARVECQSHRLTVED

PSMA7

86

O14818
RTIVHDLLTTVEELC

TSC2

381

P49815
RCRSISVSEHVVRSR

TSC2

976

P49815
RCTRQTHTHRVVDLV

TRIM56

136

Q9BRZ2
HRTRLAEIIDDCVTS

TRERF1

941

Q96PN7
LQEALTSHCVVTRGE

MYO3A

646

Q8NEV4
LQEALTSHCVVTRGE

MYO3B

651

Q8WXR4
TSHCVVTRGETIIRA

MYO3B

656

Q8WXR4
ICVCIRVTSAIHLID

NMD3

271

Q96D46