Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmonoamine transmembrane transporter activity

SLC6A4 SLC18A2 SLC22A3

9.66e-0612723GO:0008504
GeneOntologyMolecularFunctiondioxygenase activity

KDM4C ETHE1 TET1 POR KDM4B

2.77e-0598725GO:0051213
GeneOntologyMolecularFunctionsodium:chloride symporter activity

SLC6A4 SLC18A2 SLC22A3

2.95e-0517723GO:0015378
GeneOntologyMolecularFunctioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity

PDE1A PDE1C

3.84e-053722GO:0048101
GeneOntologyMolecularFunctionserotonin:sodium:chloride symporter activity

SLC6A4 SLC18A2

3.84e-053722GO:0005335
GeneOntologyMolecularFunctioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity

PDE1A PDE1C

3.84e-053722GO:0004117
GeneOntologyMolecularFunctionmonoatomic anion:sodium symporter activity

SLC6A4 SLC18A2 SLC22A3

4.18e-0519723GO:0015373
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC6A4 SLC18A2 SLC22A3

7.56e-0523723GO:0015377
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC6A4 SLC18A2 SLC22A3

1.10e-0426723GO:0015296
GeneOntologyMolecularFunctionorganic hydroxy compound transmembrane transporter activity

SLC6A4 SLC18A2 SLC22A3 ABCC11

1.19e-0470724GO:1901618
GeneOntologyMolecularFunctionhistone H3K9me2/H3K9me3 demethylase activity

KDM4C KDM4B

1.91e-046722GO:0140684
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC6A4 SLC18A2 SLC22A3 GLRA2 ABCC11

3.82e-04171725GO:0015103
GeneOntologyMolecularFunctiondemethylase activity

KDM4C MMACHC KDM4B

5.35e-0444723GO:0032451
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

KDM4C TET1 POR HMOX2 KDM4B

6.79e-04194725GO:0016705
GeneOntologyMolecularFunctionhistone H3K36 demethylase activity

KDM4C KDM4B

6.91e-0411722GO:0051864
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC6A4 SLC18A2 SLC22A3 GLRA2

1.08e-03125724GO:0015108
GeneOntologyMolecularFunctionhistone H3K9 demethylase activity

KDM4C KDM4B

1.13e-0314722GO:0032454
GeneOntologyMolecularFunctiontransmembrane-ephrin receptor activity

EPHA6 EPHA3

1.31e-0315722GO:0005005
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

KDM4C TET1 KDM4B

1.67e-0365723GO:0016706
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

EPHA6 CRIM1 EPHA3

1.67e-0365723GO:0004714
GeneOntologyMolecularFunctionephrin receptor activity

EPHA6 EPHA3

2.11e-0319722GO:0005003
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC6A4 SLC18A2 SLC22A3 GLRA2

2.17e-03151724GO:0008509
GeneOntologyMolecularFunctionhelicase activity

DHX15 TDRD9 RTEL1 ZRANB3

2.56e-03158724GO:0004386
GeneOntologyMolecularFunctionneurotransmitter transmembrane transporter activity

SLC6A4 SLC22A3

2.58e-0321722GO:0005326
GeneOntologyMolecularFunction3',5'-cyclic-AMP phosphodiesterase activity

PDE1A PDE1C

2.83e-0322722GO:0004115
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC6A4 SLC18A2 SLC22A3

3.14e-0381723GO:0015370
GeneOntologyMolecularFunction3',5'-cyclic-GMP phosphodiesterase activity

PDE1A PDE1C

3.36e-0324722GO:0047555
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

EPHA6 CRIM1 EPHA3

3.59e-0385723GO:0019199
GeneOntologyMolecularFunction3',5'-cyclic-nucleotide phosphodiesterase activity

PDE1A PDE1C

3.65e-0325722GO:0004114
GeneOntologyMolecularFunctiontransaminase activity

PHYKPL ACCS

3.94e-0326722GO:0008483
GeneOntologyMolecularFunctioncyclic-nucleotide phosphodiesterase activity

PDE1A PDE1C

4.25e-0327722GO:0004112
GeneOntologyMolecularFunctiontransferase activity, transferring nitrogenous groups

PHYKPL ACCS

4.56e-0328722GO:0016769
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM4C KDM4B

4.56e-0328722GO:0141052
GeneOntologyMolecularFunctionATP hydrolysis activity

DHX15 TDRD9 RTEL1 ABCC11 DNAH9 ABCA7

5.13e-03441726GO:0016887
GeneOntologyMolecularFunctionmethyl-CpG binding

TET1 ZBTB21

5.57e-0331722GO:0008327
GeneOntologyMolecularFunctionhistone demethylase activity

KDM4C KDM4B

5.57e-0331722GO:0032452
GeneOntologyMolecularFunctionprotein kinase activity

SCYL2 CCNH GAK EPHA6 CRIM1 IRAK4 EPHA3

5.82e-03600727GO:0004672
GeneOntologyMolecularFunctionprotein demethylase activity

KDM4C KDM4B

5.93e-0332722GO:0140457
GeneOntologyBiologicalProcessserotonin uptake

SLC6A4 SLC18A2 SLC22A3

1.38e-0514713GO:0051610
GeneOntologyBiologicalProcessfasciculation of sensory neuron axon

MEGF8 EPHA3

3.50e-053712GO:0097155
GeneOntologyBiologicalProcesshistamine uptake

SLC18A2 SLC22A3

6.98e-054712GO:0051615
GeneOntologyCellularComponentpericentric heterochromatin

NCAPD3 INCENP KDM4C KDM4B

4.57e-0632734GO:0005721
DomainPDEase_N

PDE1A PDE1C

4.39e-053722IPR013706
DomainPDEase_I_N

PDE1A PDE1C

4.39e-053722PF08499
DomainTUDOR

TDRD9 KDM4C KDM4B

9.20e-0523723PS50304
DomainTUDOR

TDRD9 KDM4C KDM4B

1.50e-0427723SM00333
DomainTudor

TDRD9 KDM4C KDM4B

2.07e-0430723IPR002999
DomainCyclin_L/T

CCNL2 CCNH

4.04e-048722IPR015429
Domain-

DHX15 TDRD9 RTEL1 ABCC11 TEP1 DNAH9 ABCA7 HYDIN ZRANB3 AGAP1

5.55e-0474672103.40.50.300
DomainJmjN

KDM4C KDM4B

6.46e-0410722SM00545
DomainJMJN

KDM4C KDM4B

6.46e-0410722PS51183
DomainJmjN

KDM4C KDM4B

6.46e-0410722PF02375
DomainJmjN

KDM4C KDM4B

6.46e-0410722IPR003349
DomainHEAT

SCYL2 NCAPD3 INTS4

8.39e-0448723PF02985
DomainRECEPTOR_TYR_KIN_V_2

EPHA6 EPHA3

1.29e-0314722PS00791
DomainRECEPTOR_TYR_KIN_V_1

EPHA6 EPHA3

1.29e-0314722PS00790
DomainEph_TM

EPHA6 EPHA3

1.29e-0314722IPR027936
DomainTyr_kinase_rcpt_V_CS

EPHA6 EPHA3

1.29e-0314722IPR001426
DomainEPH_lbd

EPHA6 EPHA3

1.29e-0314722SM00615
DomainEphrin_lbd

EPHA6 EPHA3

1.29e-0314722PF01404
DomainEphA2_TM

EPHA6 EPHA3

1.29e-0314722PF14575
DomainTyr_kinase_ephrin_rcpt

EPHA6 EPHA3

1.29e-0314722IPR016257
DomainEphrin_rcpt_lig-bd_dom

EPHA6 EPHA3

1.29e-0314722IPR001090
DomainEPH_LBD

EPHA6 EPHA3

1.29e-0314722PS51550
DomainHEAT

SCYL2 NCAPD3 INTS4

1.46e-0358723IPR000357
DomainP-loop_NTPase

DHX15 TDRD9 RTEL1 ABCC11 TEP1 DNAH9 ABCA7 HYDIN ZRANB3 AGAP1

1.47e-038487210IPR027417
DomainHA2

DHX15 TDRD9

2.15e-0318722SM00847
DomainHA2

DHX15 TDRD9

2.15e-0318722PF04408
DomainHelicase-assoc_dom

DHX15 TDRD9

2.15e-0318722IPR007502
DomainAAA+_ATPase

DHX15 ABCC11 DNAH9 ABCA7

2.32e-03144724IPR003593
DomainAAA

DHX15 ABCC11 DNAH9 ABCA7

2.32e-03144724SM00382
DomainVWC_out

CRIM1 MUC6

2.40e-0319722SM00215
DomainPDEase

PDE1A PDE1C

2.40e-0319722IPR023088
DomainHEAT_REPEAT

SCYL2 NCAPD3 INTS4

2.50e-0370723PS50077
DomainPDEase_I

PDE1A PDE1C

2.94e-0321722PF00233
DomainPDEASE_I

PDE1A PDE1C

2.94e-0321722PS00126
DomainPDEase_CS

PDE1A PDE1C

2.94e-0321722IPR023174
DomainGrowth_fac_rcpt_

EPHA6 CRIM1 MEGF8 EPHA3

3.10e-03156724IPR009030
DomainEPHD

KDM4C KDM4B

3.22e-0322722PS51805
Domain-

PDE1A PDE1C

3.22e-03227221.10.1300.10
DomainPDEase_catalytic_dom

PDE1A PDE1C

3.52e-0323722IPR002073
DomainHDc

PDE1A PDE1C

3.83e-0324722SM00471
DomainHD/PDEase_dom

PDE1A PDE1C

3.83e-0324722IPR003607
DomainJmjC

KDM4C KDM4B

3.83e-0324722PF02373
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

USP10 NCAPD3 TET1 ZBTB21 ADGRB3 DIXDC1 CNOT1 KDM4B ZNF687 AGAP1

1.60e-07529731014621295
Pubmed

Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies.

SLC6A4 SLC18A2 SLC22A3

1.77e-07673315135235
Pubmed

Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients.

SLC6A4 PDE1A PDE1C

4.93e-07873320110084
Pubmed

EphrinA5 Signaling Is Required for the Distinctive Targeting of Raphe Serotonin Neurons in the Forebrain.

SLC6A4 EPHA6 EPHA3

1.05e-061073328197551
Pubmed

Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice.

SLC6A4 SLC22A3

4.35e-06273219033200
Pubmed

Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice.

SLC6A4 SLC22A3

4.35e-06273212584728
Pubmed

Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes.

SLC6A4 SLC18A2

4.35e-06273211279528
Pubmed

Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis.

PDE1A PDE1C

4.35e-06273211369604
Pubmed

Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release.

SLC6A4 SLC18A2

4.35e-06273211517274
Pubmed

Repeated swim impairs serotonin clearance via a corticosterone-sensitive mechanism: organic cation transporter 3, the smoking gun.

SLC6A4 SLC22A3

4.35e-06273221068324
Pubmed

A kinome-wide siRNA screen identifies multiple roles for protein kinases in hypoxic stress adaptation, including roles for IRAK4 and GAK in protection against apoptosis in VHL-/- renal carcinoma cells, despite activation of the NF-κB pathway.

GAK IRAK4

4.35e-06273223591012
Pubmed

Severe serotonin depletion after conditional deletion of the vesicular monoamine transporter 2 gene in serotonin neurons: neural and behavioral consequences.

SLC6A4 SLC18A2

4.35e-06273221814181
Pubmed

Transient developmental expression of monoamine transporters in the rodent forebrain.

SLC6A4 SLC18A2

4.35e-0627329826275
Pubmed

Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity.

KDM4C KDM4B

4.35e-06273224361252
Pubmed

Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin.

SLC6A4 SLC18A2

1.30e-05373223841816
Pubmed

Serotonin homeostasis in the materno-foetal interface at term: Role of transporters (SERT/SLC6A4 and OCT3/SLC22A3) and monoamine oxidase A (MAO-A) in uptake and degradation of serotonin by human and rat term placenta.

SLC6A4 SLC22A3

1.30e-05373232311818
Pubmed

Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development.

KDM4C KDM4B

1.30e-05373227266524
Pubmed

Heme oxygenase isoforms differ in their subcellular trafficking during hypoxia and are differentially modulated by cytochrome P450 reductase.

POR HMOX2

1.30e-05373222545110
Pubmed

Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase.

PDE1A PDE1C

1.30e-0537329003415
Pubmed

The histone demethylase JMJD2C is stage-specifically expressed in preimplantation mouse embryos and is required for embryonic development.

KDM4C KDM4B

1.30e-05373219696013
Pubmed

Protein/protein interactions in the mammalian heme degradation pathway: heme oxygenase-2, cytochrome P450 reductase, and biliverdin reductase.

POR HMOX2

1.30e-05373225196843
Pubmed

Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+.

PDE1A PDE1C

1.30e-05373218335582
Pubmed

Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons.

PDE1A PDE1C

1.30e-0537327568196
Pubmed

Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells.

KDM4C KDM4B

1.30e-05373217611647
Pubmed

Postnatal growth defects in mice with constitutive depletion of central serotonin.

SLC6A4 SLC18A2

1.30e-05373223336056
Pubmed

The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance.

KDM4C KDM4B

1.30e-05373231434704
Pubmed

Histone demethylase JMJD2B and JMJD2C induce fibroblast growth factor 2: mediated tumorigenesis of osteosarcoma.

KDM4C KDM4B

1.30e-05373225636512
Pubmed

Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes.

PDE1A PDE1C

1.30e-05373217726023
Pubmed

Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex.

SLC6A4 CRIM1 EMX2

2.23e-052673318957218
Pubmed

Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and Central Apparatus in Patients with Transposition of the Great Arteries.

DNAH9 HYDIN

2.60e-05473236140829
Pubmed

The histone demethylase Kdm4 suppresses activation of hepatic stellate cell by inducing MiR-29 transcription.

KDM4C KDM4B

2.60e-05473231014673
Pubmed

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.

KDM4C KDM4B

2.60e-05473218713068
Pubmed

Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.

KDM4C KDM4B

2.60e-05473227257215
Pubmed

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.

KDM4C KDM4B

4.33e-05573216738407
Pubmed

Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter.

TET1 LYST

4.33e-05573229858571
Pubmed

Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.

KDM4C KDM4B

4.33e-05573221914792
Pubmed

Excess of serotonin (5-HT) alters the segregation of ispilateral and contralateral retinal projections in monoamine oxidase A knock-out mice: possible role of 5-HT uptake in retinal ganglion cells during development.

SLC6A4 SLC18A2

4.33e-05573210436056
Pubmed

Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex.

SLC6A4 CRIM1 EMX2

4.63e-053373327100196
Pubmed

Identification and characterization of JMJD2 family genes in silico.

KDM4C KDM4B

6.48e-05673215138608
Pubmed

Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3.

SLC6A4 SLC22A3

6.48e-05673220858707
Pubmed

Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior.

SLC6A4 SLC18A2

6.48e-05673212546819
Pubmed

Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice.

EPHA6 EPHA3

6.48e-05673216910173
Pubmed

Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization.

SLC6A4 EMX2

6.48e-05673217202185
Pubmed

Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system.

EPHA6 EPHA3

6.48e-05673215996548
Pubmed

Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development.

KDM4C KDM4B

9.06e-05773221445275
Pubmed

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.

KDM4C KDM4B

9.06e-05773228262558
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

RTF1 CCNL2 CCNH GAK INCENP IRAK4 NKTR LYST ZNF687

1.20e-0491073936736316
Pubmed

Mistargeting hippocampal axons by expression of a truncated Eph receptor.

EPHA6 EPHA3

1.21e-04873212124402
Pubmed

Transcription factor Foxd1 is required for the specification of the temporal retina in mammals.

SLC6A4 EPHA6

1.21e-04873221490208
Pubmed

Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity.

SLC6A4 SLC18A2

1.21e-04873217151281
Pubmed

Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons.

SLC6A4 SLC22A3

1.21e-04873225642596
Pubmed

Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype.

SLC6A4 SLC18A2

1.55e-04973214602809
Pubmed

IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity.

SLC6A4 SLC22A3

1.55e-04973216024787
Pubmed

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

DHX15 TRIM32 SMARCC1 CNOT1

1.61e-0412973423022380
Pubmed

Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.

EPHA6 EPHA3

1.93e-041073225073978
Pubmed

Quantitative assessment of computational models for retinotopic map formation.

EPHA6 EPHA3

1.93e-041073225367067
Pubmed

Fgf receptor 3 activation promotes selective growth and expansion of occipitotemporal cortex.

SLC6A4 EMX2

1.93e-041073219192266
Pubmed

IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway.

RTEL1 PRIM2

1.93e-041073223585563
Pubmed

A role for Pax6 in the normal development of dorsal thalamus and its cortical connections.

SLC6A4 SLC18A2

1.93e-041073211060242
Pubmed

Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse.

KDM4C KDM4B

1.93e-041073227023172
Pubmed

EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes.

EPHA6 EPHA3

1.93e-041073216547242
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

DHX15 NDUFB11 NCAPD3 CRIM1 MEGF8 LEMD3 SLC22A3 HMOX2 ABCA7 FRMD5

2.00e-041201731035696571
Pubmed

Fibroblast growth factor 8 organizes the neocortical area map and regulates sensory map topography.

SLC6A4 EMX2

2.36e-041173222623663
Pubmed

Differential patterning of genes involved in serotonin metabolism and transport in extra-embryonic tissues of the mouse.

SLC18A2 SLC22A3

2.36e-041173227238716
Pubmed

Selective inhibition of spinal cord neurite outgrowth and cell survival by the Eph family ligand ephrin-A5.

EPHA6 EPHA3

2.36e-041173210559410
Pubmed

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.

KDM4C KDM4B

2.36e-041173219144645
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

USP10 PHYKPL EPHA6 RTEL1 STXBP5L SLC22A3 UBE3C TEP1 CNOT1 KDM4B AGAP1

2.65e-041489731128611215
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

RTF1 DHX15 CCNH USP10 INCENP PRIM2 ZBTB21 SMARCC1 ZNF687

2.68e-04101473932416067
Pubmed

Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2.

LEMD3 POR HMOX2

3.22e-046373335993436
Pubmed

Eph-ephrin A system regulates murine blastocyst attachment and spreading.

EPHA6 EPHA3

3.34e-041373217039519
Pubmed

Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of VGF.

SLC6A4 BTBD3

3.34e-041373235289744
Pubmed

EphA family gene expression in the developing mouse neocortex: regional patterns reveal intrinsic programs and extrinsic influence.

EPHA6 EPHA3

3.34e-041373212528186
Pubmed

Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.

PDE1A PDE1C

3.34e-04137328557689
Pubmed

Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.

CCNL2 CRIM1 POR ABCC11 USPL1 TEP1 RSPH10B EPHA3

3.54e-0483273836724073
Pubmed

Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.

NCAPD3 SMARCC1 CNOT1

3.69e-046673323275444
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

SCYL2 DHX15 USP10 PRIM2 SMARCC1 UBE3C CNOT1

3.87e-0463873733239621
Pubmed

Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue.

EPHA6 EPHA3

3.89e-041473226941654
Pubmed

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.

KDM4C KDM4B

3.89e-041473216603238
Pubmed

Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes.

PDE1A PDE1C

3.89e-041473225852085
Pubmed

A role for the EphA family in the topographic targeting of vomeronasal axons.

EPHA6 EPHA3

3.89e-041473211222144
Pubmed

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.

RTF1 CCNH NDUFB11 TRIM32 PRIM2 LYST

4.03e-0445773632968282
Pubmed

MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.

RTEL1 PRIM2

4.48e-041573222678361
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

RTEL1 STXBP5L MUC6

4.58e-047173333541421
Pubmed

Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.

SLC6A4 SLC18A2

5.12e-041673219693267
Pubmed

Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice.

EPHA6 EPHA3

5.79e-041773212217323
Pubmed

HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathway.

HLA-DMB LYST

6.51e-041873219620308
Pubmed

Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function.

SLC6A4 SLC18A2

6.51e-041873226879466
Pubmed

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.

DHX15 USP10

6.51e-041873227558965
Pubmed

Expression of Ephs and ephrins in developing mouse inner ear.

EPHA6 EPHA3

7.26e-041973212684176
Pubmed

Gene expression analysis of the embryonic subplate.

PDE1A CRIM1 GLRA2 EPHA3

7.86e-0419673421862448
Pubmed

Pet-1 is required across different stages of life to regulate serotonergic function.

SLC6A4 SLC18A2

8.06e-042073220818386
Pubmed

Rnf220 is Implicated in the Dorsoventral Patterning of the Hindbrain Neural Tube in Mice.

SLC6A4 SLC18A2

8.06e-042073235399523
Pubmed

Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.

RTEL1 PRIM2 USPL1

8.85e-048973323891004
Pubmed

Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.

EPHA6 EPHA3

8.89e-04217329267020
Pubmed

Eph receptors and ephrins demarcate cerebellar lobules before and during their formation.

EPHA6 EPHA3

8.89e-042173210495276
Pubmed

Dorsal root ganglion axon bifurcation tolerates increased cyclic GMP levels: the role of phosphodiesterase 2A and scavenger receptor Npr3.

PDE1A PDE1C

8.89e-042173227740716
Pubmed

Developmental expression of Eph and ephrin family genes in mammalian small intestine.

EPHA6 EPHA3

8.89e-042173220112066
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KDM4C KDM4B

8.89e-042173227626377
Pubmed

Roles of Eph receptors and ephrins in segmental patterning.

EPHA6 EPHA3

8.89e-042173211128993
Pubmed

Eph receptors and ephrins: regulators of guidance and assembly.

EPHA6 EPHA3

8.89e-042173210730216
InteractionCIB2 interactions

GAK RTEL1 TRIM32 TEP1 FRMD5

9.13e-0681705int:CIB2
GeneFamilyTudor domain containing

TDRD9 KDM4C KDM4B

1.63e-0437523780
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHA6 EPHA3

7.22e-04145221095
GeneFamilyPHD finger proteins|Lysine demethylases

KDM4C KDM4B

2.15e-0324522485
GeneFamilyPhosphodiesterases

PDE1A PDE1C

2.15e-0324522681
GeneFamilyCyclins

CCNL2 CCNH

2.92e-0328522473
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C EPHA6 SPHKAP C12orf42 EPHA3

5.14e-071807368923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Deep_Layer-37|World / Primary Cells by Cluster

PDE1A TDRD9 STXBP5L SPHKAP ADAMTS16 AGAP1

8.71e-0719773600d756bc0231e1b3b88430214338c1059cb11106
ToppCelldroplet-Liver-Hepatocytes-24m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HLA-DMB SLC18A2 SLC22A3 PRIM2 PSRC1

6.60e-061607359f24ee4fe1ba4590dce5dd4d43707fb007dca82f
ToppCelldroplet-Liver-Hepatocytes-24m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HLA-DMB SLC18A2 SLC22A3 PRIM2 PSRC1

6.60e-061607353b3b99305558f5b49d050fb9b249007630ea9085
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C SPHKAP C12orf42 EPHA3

9.38e-0617273592e76cbf4807704790f42cf2507e92f85cd3bc92
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C SPHKAP C12orf42 EPHA3

9.64e-061737355aa4d45a01d2d09eff8b4deb32bd91ab2471210a
ToppCellMild/Remission-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

CRIM1 HLA-DMB LYST KDM4B BTBD3

9.64e-06173735694d02c4d2dc2de4b344544f9124fec40fcf7d8f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C SPHKAP C12orf42 EPHA3

9.92e-061747352947e5906b172d149412fa4e77476fce4ea695d2
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CRIM1 INCENP PSRC1 BTBD3 AGAP1

1.02e-0517573515c69dd5635c9251c535f1e22467712e9667ae92
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1C LEMD3 STXBP5L SPHKAP BTBD3

1.02e-0517573565571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C CRIM1 SPHKAP EPHA3

1.08e-051777357e799333307448c6a94d1f33dbc59c543336f45e
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C EPHA6 SPHKAP EPHA3

1.14e-05179735c815eb9f760fe4ca7a5e49beb224659f0b864f22
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1C STXBP5L ADAMTS16 DNAH9 HYDIN

1.30e-051847352cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1C STXBP5L ADAMTS16 DNAH9 HYDIN

1.30e-05184735ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1C STXBP5L ADAMTS16 DNAH9 HYDIN

1.30e-051847352b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C CRIM1 SPHKAP EPHA3

1.30e-051847359cc5c588f7c6631b3fb8a522214a09ca32947e72
ToppCellMild/Remission-B_naive-8|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

CRIM1 HLA-DMB LYST KDM4B BTBD3

1.72e-051957350a3221e4d1fa31a35868bdda0f0cc873c233b407
ToppCellControl-Control-Lymphocyte-T/NK-NK_activated|Control / Disease, condition lineage and cell class

SLC6A4 MEGF8 INCENP FRMD5 MMACHC

1.85e-0519873576d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCellNeuronal-Excitatory-eG(DAPK2)-|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1C EPHA6 SPHKAP C12orf42 EPHA3

1.94e-052007357cea58e2691564e653cc972bf5aaff2df1f2666e
ToppCellNeuronal-Excitatory-eG(DAPK2)--|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1C EPHA6 SPHKAP C12orf42 EPHA3

1.94e-05200735193c42c31a366a60d80c4c1fc6a1592a5b01a3ad
ToppCellNeuronal-Excitatory-eG(DAPK2)---|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1C EPHA6 SPHKAP C12orf42 EPHA3

1.94e-052007357c780e995a5fc3793080da61b6bf7a12880e9df8
ToppCellNeuronal-Excitatory-eG(DAPK2)----L4-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1C EPHA6 SPHKAP C12orf42 EPHA3

1.94e-05200735d0b31dc5eedc0635c0d7ceabaa6202386cf2a4a4
ToppCellNeuronal-Excitatory-eG(DAPK2)|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1C EPHA6 SPHKAP C12orf42 EPHA3

1.94e-052007358444ae3c10b1152dec67ca812e6c417cc3b9cf89
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Tubulolobular_Carcinoma|TCGA-Breast / Sample_Type by Project: Shred V9

TDRD9 KDM4C SLC18A2 ADAMTS16

2.90e-05107734e5c1ce2b31e3e5b7acd930b7903e7cd1fb4d285c
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Tubulolobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

TDRD9 KDM4C SLC18A2 ADAMTS16

2.90e-05107734a749d56a0a2fe719f8e76bea15be85d6f7770b12
ToppCellRV-14._Fibroblast_III|RV / Chamber and Cluster_Paper

EPHA6 ADGRB3 EMX2 EPHA3

8.27e-05140734b4fee8eb6bf855b364b00bda3f78e49d851bbca0
ToppCellMS-CD8-exh_CD4|MS / Condition, Cell_class and T cell subcluster

CCDC27 TRIM32 ABCC11 USPL1

8.74e-051427347591491520a883bb09fa2b8d0a20ae2abd2b8703
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

EPHA6 STXBP5L DNAH9 FRMD5

9.73e-05146734c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
Drug5-mm AI

SLC6A4 TRIM32 SLC18A2

6.81e-0612733CID000131575
Drugtalopram

SLC6A4 TRIM32 SLC18A2

6.81e-0612733CID000023573
Drug2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-

SLC6A4 SLC18A2

1.01e-052732ctd:D012369
Diseasecocaine abuse (implicated_via_orthology)

SLC6A4 SLC18A2

1.57e-053682DOID:809 (implicated_via_orthology)
Diseasemedulloblastoma (is_marker_for)

KDM4C KDM4B

5.21e-055682DOID:0050902 (is_marker_for)
Diseaselipoprotein-associated phospholipase A(2) measurement

SLC22A3 PSRC1 FRMD5

1.09e-0440683EFO_0004746
Diseasealopecia areata (is_marker_for)

KDM4C KDM4B

2.33e-0410682DOID:986 (is_marker_for)
Diseasestomach cancer (is_implicated_in)

EMX2 TEP1 KDM4B

6.23e-0472683DOID:10534 (is_implicated_in)
Diseasestem Cell Growth Factor beta measurement

SCYL2 KDM4C C12orf42

7.02e-0475683EFO_0008292
Diseaseparental longevity

DHX15 SLC6A4 SLC22A3 PRIM2 POR PSRC1

9.73e-04494686EFO_0007796
Diseasehealth study participation

PDE1A KDM4B BTBD3 AGAP1

1.08e-03195684EFO_0010130
Diseaseanxiety disorder (implicated_via_orthology)

SLC6A4 SLC18A2

1.17e-0322682DOID:2030 (implicated_via_orthology)
Diseasepulmonary arterial hypertension

PDE1A C12orf42

1.17e-0322682EFO_0001361
Diseasevasculitis

GAK KDM4C

1.40e-0324682EFO_0006803
Diseaselongevity, healthspan, parental longevity

SLC6A4 PSRC1

2.04e-0329682EFO_0004300, EFO_0007796, EFO_0009762
DiseaseParkinsonian Disorders

SLC18A2 LYST

2.18e-0330682C0242422

Protein segments in the cluster

PeptideGeneStartEntry
CPDERFVLMATPNLS

AGAP1

826

Q9UPQ3
EFCSVFKPAMPRSVV

CCNH

66

P51946
MFTLPQKDFRAPTTC

ACCS

1

Q96QU6
LPFEPRTAVKNFMAS

ADGRB3

1376

O60242
FQTGTPLERPCFRMK

C2orf48

101

Q96LS8
FTDRSLTPFMVNIPK

DIXDC1

606

Q155Q3
CLTFFLMLPETVKNR

BTBD3

11

Q9Y2F9
TAMLSVPQCFVRPTE

DHX15

591

O43143
RNILKFKPPMCFSLD

PHYKPL

406

Q8IUZ5
FKPPMCFSLDNARQV

PHYKPL

411

Q8IUZ5
MSFCNPKTRPVTGLV

ADAMTS16

906

Q8TE57
LFAPDTPFTRKLMAQ

ABCA7

296

Q8IZY2
MFEAIFPSTPQARLK

CCDC27

1

Q2M243
IFNAAKTCPTMPALF

INTS4

551

Q96HW7
SLTPCLKIRNMFDPV

LEMD3

781

Q9Y2U8
LFLCFTKLMTENIRP

RSPH10B

516

P0C881
LFLCFTKLMTENIRP

RSPH10B2

516

B2RC85
RPQMFLASCQAPKTF

MUC6

756

Q6W4X9
PSMRCETVFKLTPEF

C22orf46

81

C9J442
SQFRLPFKATTPVIM

POR

516

P16435
KRNTPLRMDPKCSFV

INCENP

521

Q9NQS7
RFSPPPAMEKCLVFE

PUDP

161

Q08623
PFSPLCDRKSTMVAQ

PDE1A

401

P54750
PFSPLCDRKSTMVAQ

PDE1C

411

Q14123
NKVFRCPMSFFDTIP

ABCC11

901

Q96J66
KMASRPFAKVTVCFP

MEGF8

2691

Q7Z7M0
RQKTRPLIPEMCFTS

KDM4B

721

O94953
VESPLNPSCKIMTFR

KDM4C

6

Q9H3R0
VFIFNLKLPDCPSTM

LCT

276

P09848
MKRESPTCNLFPASK

PSRC1

171

Q6PGN9
SCPFRTAMAVLRKPS

HMOX2

281

P30519
PITMSFPFCQSRKIL

OR2T34

166

Q8NGX1
PITMSFPFCQSRKIL

OR2T3

166

Q8NH03
PAMFDRALKPFLQSC

MMACHC

56

Q9Y4U1
IDLLSTKSFPPCMRQ

PRIM2

276

P49643
VMTPVPLFSKQRSGC

GAK

581

O14976
QLRSQPPFTMCFRVK

FRMD5

81

Q7Z6J6
KTTPFNTREPVMLAC

HLA-DMB

121

P28068
TECRMPDIALPSQFV

HYDIN

4866

Q4G0P3
NCLLPDDKLRFTPSM

CCNL2

51

Q96S94
PFEFPSQDMCLSALK

CRIM1

151

Q9NZV1
KCPFTVKNLAMFPDT

EPHA3

201

P29320
KAMISSPPFRAICQE

CFHR5

546

Q9BXR6
LTPMPREVCRSFVKI

LYST

1981

Q99698
APILLRQMFEPVSCT

ETHE1

21

O95571
LTLTLSCPMDLKNFP

GLRA2

166

P23416
PFCDKDRTLMTPVQN

IRAK4

126

Q9NWZ3
MFQPAPKRCFTIESL

EMX2

1

Q04743
ELPENLKSLFRPCAM

DNAH9

1981

Q9NYC9
PSFLDLVRTPQMRKC

SLC22A3

336

O75751
IMESNCFDPSKIQLP

NDUFB11

136

Q9NX14
KCPFTVRNLAMFPDT

EPHA6

206

Q9UF33
SSFALEMQIPFPVCL

RTEL1

486

Q9NZ71
MDPFTRRQCKPTIVS

RTF1

591

Q92541
SEFLMTPNVPCRSLK

SPHKAP

966

Q2M3C7
PICMESFTEEQLRPK

TRIM32

21

Q13049
FQALEFKICKMRPSA

TDRD9

1006

Q8NDG6
GRIMFQLFSDICPKT

NKTR

21

P30414
RILPCLTSEFVNPDM

SCYL2

371

Q6P3W7
VTNPAFTKLPAKCFM

SMARCC1

96

Q92922
PPFRKAQSAACMEIS

STXBP5L

786

Q9Y2K9
KMFAQDTVCAPFPQR

TET1

241

Q8NFU7
PNISMCLKDSDPFIR

NCAPD3

981

P42695
LTIRPFANRMQKSPC

C12orf42

16

Q96LP6
PFIQACMTFLKRRCP

CNOT1

611

A5YKK6
EMPLESKCTSFPQAL

USPL1

211

Q5W0Q7
APPLSAITFKRQFMC

ZBTB21

1031

Q9ULJ3
PLPACLRTAMTDKFA

TEP1

356

Q99973
RPQMTFCRLQRIFPK

SSX7

96

Q7RTT5
APDKTCMQFSIRRPK

TBC1D16

366

Q8TBP0
CMQFSIRRPKLPSSE

TBC1D16

371

Q8TBP0
EVPSFLMICQRRSPA

UNQ9370/PRO34162

11

Q6UXP9
KVQRPCTSTPMIDSF

USP10

451

Q14694
PSCPLLFAQKRTMLE

ZNF687

861

Q8N1G0
FIICSFLMSPPQLRL

SLC6A4

551

P31645
LCFFLRSPPAKEEKM

SLC18A2

466

Q05940
PTASTCMNLLKLPEF

UBE3C

1046

Q15386
FVPQPKKRQLMTSCD

ZRANB3

526

Q5FWF4