Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesssnRNA transcription by RNA polymerase II

ELL2 ELL3 ELL

7.80e-0616513GO:0042795
GeneOntologyBiologicalProcesssnRNA metabolic process

ELL2 RBM7 ELL3 ELL

1.36e-0559514GO:0016073
GeneOntologyBiologicalProcesssnRNA transcription

ELL2 ELL3 ELL

1.58e-0520513GO:0009301
GeneOntologyBiologicalProcessmeiotic spindle organization

TUBG2 DICER1 TUBG1

1.04e-0437513GO:0000212
GeneOntologyBiologicalProcesscellular component disassembly

VANGL2 SPTBN1 APC ACIN1 GABARAPL3 SSRP1 ADAM10 DICER1

1.25e-04617518GO:0022411
GeneOntologyCellularComponenttranscription elongation factor complex

ELL2 SSRP1 ELL3 ELL

9.70e-0656504GO:0008023
GeneOntologyCellularComponentpericentriolar material

TUBG2 CEP192 TUBG1

4.04e-0528503GO:0000242
GeneOntologyCellularComponentlateral plasma membrane

VANGL2 VANGL1 APC IQGAP3

6.36e-0590504GO:0016328
GeneOntologyCellularComponentendoplasmic reticulum lumen

PCSK1 FAM20C CALU NUCB1 APOB ADAM10

1.35e-04332506GO:0005788
GeneOntologyCellularComponentperinuclear region of cytoplasm

PCSK1 RASGRP3 APC KCNS1 AKAP13 CPD CLINT1 ADAM10 DICER1

3.28e-04934509GO:0048471
HumanPhenoThyroid nodule

APC DICER1

3.95e-053192HP:0025388
HumanPhenoCerebellar medulloblastoma

APC DICER1

3.95e-053192HP:0007129
DomainELL

ELL2 ELL3 ELL

1.81e-083503PF10390
DomainELL_N

ELL2 ELL3 ELL

1.81e-083503IPR019464
DomainELL/occludin

ELL2 ELL3 ELL

3.59e-076503IPR031176
DomainOccludin_ELL

ELL2 ELL3 ELL

3.59e-076503IPR010844
DomainOccludin_ELL

ELL2 ELL3 ELL

3.59e-076503PF07303
DomainVANGL

VANGL2 VANGL1

7.02e-062502IPR009539
DomainStrabismus

VANGL2 VANGL1

7.02e-062502PF06638
DomainGamma_tubulin

TUBG2 TUBG1

7.02e-062502IPR002454
DomainC1

KMT2C RASGRP3 AKAP13

7.02e-0465503SM00109
DomainPE/DAG-bd

KMT2C RASGRP3 AKAP13

7.34e-0466503IPR002219
Domain-

TUBG2 TUBG1

1.29e-03205023.30.1330.20
Domain-

TUBG2 TUBG1

1.43e-03215021.10.287.600
DomainTubulin_C

TUBG2 TUBG1

1.57e-0322502SM00865
DomainTubulin_C

TUBG2 TUBG1

1.57e-0322502PF03953
DomainTubulin/FtsZ_2-layer-sand-dom

TUBG2 TUBG1

1.57e-0322502IPR018316
Domain-

TUBG2 TUBG1

1.57e-03225023.40.50.1440
DomainTubulin_C

TUBG2 TUBG1

1.71e-0323502IPR023123
DomainTUBULIN

TUBG2 TUBG1

1.71e-0323502PS00227
DomainTubulin

TUBG2 TUBG1

1.71e-0323502IPR000217
DomainTub_FtsZ_C

TUBG2 TUBG1

1.71e-0323502IPR008280
DomainTubulin

TUBG2 TUBG1

1.71e-0323502SM00864
DomainTubulin_CS

TUBG2 TUBG1

1.71e-0323502IPR017975
DomainTubulin_FtsZ_GTPase

TUBG2 TUBG1

1.87e-0324502IPR003008
DomainTubulin

TUBG2 TUBG1

1.87e-0324502PF00091
DomainEF-hand_5

CALU RASGRP3

2.03e-0325502PF13202
Domain-

RPRD2 CLINT1

2.19e-03265021.25.40.90
DomainRRM

RBM7 RBM5 ACIN1 HNRNPA2B1

2.69e-03217504SM00360
DomainENTH_VHS

RPRD2 CLINT1

2.72e-0329502IPR008942
DomainRRM_dom

RBM7 RBM5 ACIN1 HNRNPA2B1

3.16e-03227504IPR000504
Domain-

RBM7 RBM5 ACIN1 HNRNPA2B1

4.09e-032445043.30.70.330
DomainNucleotide-bd_a/b_plait

RBM7 RBM5 ACIN1 HNRNPA2B1

4.98e-03258504IPR012677
PathwayREACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS

FAM20C CALU NUCB1 APOB ADAM10

4.26e-05120465MM14982
PathwayREACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS

FAM20C CALU NUCB1 APOB ADAM10

4.99e-05124465M27285
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIBES_SNRNA_GENES

ELL2 RPRD2 ELL3 ELL

9.16e-0573464MM15349
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIBES_SNRNA_GENES

ELL2 RPRD2 ELL3 ELL

1.37e-0481464M27647
PathwayREACTOME_RND3_GTPASE_CYCLE

VANGL2 VANGL1 CPD

3.41e-0442463M41826
PathwayREACTOME_RND1_GTPASE_CYCLE

VANGL2 VANGL1 CPD

3.41e-0442463M41828
PathwayREACTOME_RND3_GTPASE_CYCLE

VANGL2 VANGL1 CPD

3.41e-0442463MM15677
PathwayREACTOME_RND1_GTPASE_CYCLE

VANGL2 VANGL1 CPD

3.66e-0443463MM15679
PathwayREACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN_1_SIGNALING

TRPC3 NTN1

4.61e-0410462M27330
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

BICD2 CALU MTM1 RBM7 APC ACIN1 AKAP13 PPHLN1 RPRD2 HNRNPA2B1

2.75e-09503511016964243
Pubmed

Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning.

VANGL2 TUBG2 VANGL1 TUBG1

2.41e-082151420562861
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

VANGL2 HSPA12A CALU VANGL1 SPTBN1 NUCB1 ZNF622 AKAP13 CPD CEP192 SSRP1 DICER1 HNRNPA2B1

1.58e-071487511333957083
Pubmed

Rack1 regulates cellular patterning and polarity in the mouse cochlea.

VANGL2 TUBG2 TUBG1

1.65e-07851336252648
Pubmed

Ciliary proteins link basal body polarization to planar cell polarity regulation.

VANGL2 TUBG2 TUBG1

2.48e-07951318066062
Pubmed

A dual role for planar cell polarity genes in ciliated cells.

VANGL2 TUBG2 TUBG1

4.86e-071151325024228
Pubmed

Loss of Zic3 impairs planar cell polarity leading to abnormal left-right signaling, heart defects and neural tube defects.

VANGL2 TUBG2 TUBG1

4.86e-071151334274973
Pubmed

Regulation of cochlear convergent extension by the vertebrate planar cell polarity pathway is dependent on p120-catenin.

VANGL2 TUBG2 TUBG1

6.47e-071251322318628
Pubmed

The little elongation complex regulates small nuclear RNA transcription.

ELL2 ELL3 ELL

6.47e-071251322195968
Pubmed

Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities.

TUBG2 VANGL1 TUBG1

1.07e-061451324381198
Pubmed

The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway.

VANGL2 TUBG2 TUBG1

1.33e-061551326035863
Pubmed

Strabismus regulates asymmetric cell divisions and cell fate determination in the mouse brain.

VANGL2 TUBG2 TUBG1

1.64e-061651319332887
Pubmed

The ciliopathy gene Rpgrip1l is essential for hair follicle development.

TUBG2 VANGL1 TUBG1

1.99e-061751325398052
Pubmed

Differential expression of human γ-tubulin isotypes during neuronal development and oxidative stress points to a γ-tubulin-2 prosurvival function.

TUBG2 TUBG1

2.11e-06251228119396
Pubmed

A novel hypomorphic Looptail allele at the planar cell polarity Vangl2 gene.

VANGL2 VANGL1

2.11e-06251221404367
Pubmed

Effects of retinoic acid on the expressions of Vangl1 and vangl2 in mouse fetuses.

VANGL2 VANGL1

2.11e-06251219012162
Pubmed

Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival.

ELL2 ELL3

2.11e-06251228858629
Pubmed

MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages.

TUBG2 TUBG1

2.11e-06251217442887
Pubmed

The homologous genes Vangl1 and Vangl2 are required for embryo implantation in the uterus of mice during early pregnancy.

VANGL2 VANGL1

2.11e-06251225445275
Pubmed

Independent mutations at Arg181 and Arg274 of Vangl proteins that are associated with neural tube defects in humans decrease protein stability and impair membrane targeting.

VANGL2 VANGL1

2.11e-06251225068569
Pubmed

Overexpression of γ-tubulin in non-small cell lung cancer.

TUBG2 TUBG1

2.11e-06251222806905
Pubmed

APC functions at the centrosome to stimulate microtubule growth.

APC TUBG1

2.11e-06251226556314
Pubmed

Gene knockout analysis of two gamma-tubulin isoforms in mice.

TUBG2 TUBG1

2.11e-06251215893303
Pubmed

Core planar cell polarity genes VANGL1 and VANGL2 in predisposition to congenital vertebral malformations.

VANGL2 VANGL1

2.11e-06251238669183
Pubmed

Allocation of gamma-tubulin between oocyte cortex and meiotic spindle influences asymmetric cytokinesis in the mouse oocyte.

TUBG2 TUBG1

2.11e-06251217287496
Pubmed

Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.

APC NTN1

2.11e-06251215343335
Pubmed

Molecular and cellular mechanisms underlying neural tube defects in the loop-tail mutant mouse.

VANGL2 VANGL1

2.11e-06251220329788
Pubmed

Vangl2, the planar cell polarity protein, is complexed with postsynaptic density protein PSD-95 [corrected].

VANGL2 VANGL1

2.11e-06251223567299
Pubmed

Loss of membrane targeting of Vangl proteins causes neural tube defects.

VANGL2 VANGL1

2.11e-06251221142127
Pubmed

Molecular characterisation of endogenous Vangl2/Vangl1 heteromeric protein complexes.

VANGL2 VANGL1

2.11e-06251223029439
Pubmed

Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.

TUBG2 APC TUBG1

3.33e-062051332294449
Pubmed

Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia.

TUBG2 VANGL1 TUBG1

3.88e-062151322935613
Pubmed

Vangl2-regulated polarisation of second heart field-derived cells is required for outflow tract lengthening during cardiac development.

VANGL2 TUBG2 TUBG1

3.88e-062151325521757
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

CALU SPTBN1 APC CEP192 CLINT1 DICER1 HNRNPA2B1 TUBG1

3.95e-0663951823443559
Pubmed

A bead-based approach for large-scale identification of in vitro kinase substrates.

CALU ACIN1 RPRD2 SSRP1 HNRNPA2B1

4.20e-0616351522113938
Pubmed

Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.

BICD2 MTM1 ACIN1 SSRP1 DICER1

4.72e-0616751525659891
Pubmed

The gamma-tubulin gene family in humans.

TUBG2 TUBG1

6.32e-06351210903841
Pubmed

Genetic interaction between members of the Vangl family causes neural tube defects in mice.

VANGL2 VANGL1

6.32e-06351218296642
Pubmed

Human TUBG2 gene is expressed as two splice variant mRNA and involved in cell growth.

TUBG2 TUBG1

6.32e-06351227015882
Pubmed

EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein.

ELL2 ELL

6.32e-06351211418481
Pubmed

Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin.

TUBG2 TUBG1

6.32e-0635129566969
Pubmed

Elevated Coexpression of KITENIN and the ErbB4 CYT-2 Isoform Promotes the Transition from Colon Adenoma to Carcinoma Following APC loss.

VANGL1 APC

6.32e-06351226527747
Pubmed

The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage.

TUBG2 TUBG1

6.32e-06351226021315
Pubmed

Dynamics of planar cell polarity protein Vangl2 in the mouse oviduct epithelium.

VANGL2 VANGL1

6.32e-06351227155041
Pubmed

ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties.

ELL2 ELL

6.32e-06351212446457
Pubmed

An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.

VANGL2 CALU VANGL1

6.68e-062551337589075
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

KMT2C CACNB3 NADSYN1 RBM5 AKAP13 NTN1 PPHLN1 RPRD2 CPD CEP192 HNRNPA2B1

8.38e-061489511128611215
Pubmed

Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo.

VANGL2 TUBG2 TUBG1

8.48e-062751324706806
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

ELL2 CALU SPTBN1 APC ZNF622 ACIN1 SSRP1 PAPSS1 HNRNPA2B1 TUBG1

1.13e-051247511027684187
Pubmed

Molecular defects in the motor adaptor BICD2 cause proximal spinal muscular atrophy with autosomal-dominant inheritance.

BICD2 DNAI1

1.26e-05451223664119
Pubmed

Loss of Necdin impairs myosin activation and delays cell polarization.

TUBG2 TUBG1

1.26e-05451220665884
Pubmed

Cilia organize ependymal planar polarity.

TUBG2 TUBG1

1.26e-05451220164345
Pubmed

Piezo mechanosensory channels regulate centrosome integrity and mitotic entry.

TUBG2 TUBG1

1.26e-05451236574677
Pubmed

Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis.

VANGL2 VANGL1

1.26e-05451220126399
Pubmed

Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells.

ELL2 ELL

1.26e-05451227058417
Pubmed

Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination.

VANGL2 VANGL1

1.26e-05451228481871
Pubmed

Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells.

TUBG2 TUBG1

1.26e-05451216798874
Pubmed

Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion.

APC NTN1

1.26e-05451223302812
Pubmed

The Wnt coreceptor Ryk regulates Wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2.

VANGL2 VANGL1

1.26e-05451223144463
Pubmed

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.

CALU VANGL1 NUCB1 PBK RBM7 PPHLN1 CPD CLINT1 SSRP1

1.41e-05100751934597346
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

SPTBN1 APC ACIN1 AKAP13 PPHLN1 RPRD2

1.46e-0536151630344098
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

CALU VANGL1 NUCB1 APC AKAP13 CPD APOB PAPSS1 ADAM10 TUBG1

1.59e-051297511033545068
Pubmed

DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes.

RBM7 RBM5 ELL

1.72e-053451332152128
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

PPHLN1 RPRD2 CLINT1 IQGAP3 ELL

1.87e-0522251537071664
Pubmed

SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP.

VANGL2 VANGL1 TUBG1

1.88e-053551339366759
Pubmed

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.

CALU VANGL1 MTM1 NUCB1 RBM5 PPHLN1

1.89e-0537851634315543
Pubmed

Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium.

TUBG2 TUBG1

2.10e-05551221285373
Pubmed

Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation.

TUBG2 TUBG1

2.10e-05551229244804
Pubmed

Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.

VANGL2 VANGL1

2.10e-05551215456783
Pubmed

Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia.

TUBG2 TUBG1

2.10e-05551231390572
Pubmed

Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components.

CEP192 TUBG1

2.10e-05551219543530
Pubmed

A two-kinesin mechanism controls neurogenesis in the developing brain.

TUBG2 TUBG1

2.10e-05551238040957
Pubmed

Regulation of microtubule formation in activated mast cells by complexes of gamma-tubulin with Fyn and Syk kinases.

TUBG2 TUBG1

2.10e-05551216751367
Pubmed

A maternal store of macroH2A is removed from pronuclei prior to onset of somatic macroH2A expression in preimplantation embryos.

TUBG2 TUBG1

2.10e-05551215680357
Pubmed

Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer.

VANGL2 VANGL1

2.10e-05551226754771
Pubmed

Analysis of Ellis van Creveld syndrome gene products: implications for cardiovascular development and disease.

TUBG2 TUBG1

2.10e-05551219251731
Pubmed

The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis.

TUBG2 TUBG1

2.10e-05551221529752
Pubmed

Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis.

TUBG2 TUBG1

2.10e-05551218729223
Pubmed

WDR62 is associated with the spindle pole and is mutated in human microcephaly.

TUBG2 TUBG1

2.10e-05551220890279
Pubmed

Speriolin is a novel human and mouse sperm centrosome protein.

TUBG2 TUBG1

2.10e-05551220542897
Pubmed

Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies.

TUBG2 TUBG1

2.10e-05551225877302
Pubmed

HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.

TUBG2 TUBG1

2.10e-05551214767062
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

HSPA12A SPTBN1 RBM7 ACIN1 CLINT1 HNRNPA2B1 TUBG1

2.17e-0558251720467437
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

VANGL2 SPTBN1 RBM7 APC RBM5 ACIN1 SSRP1 HNRNPA2B1 TUBG1

2.48e-05108251938697112
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

SPTBN1 RBM7 RBM5 ACIN1 PPHLN1 APOB CLINT1 SSRP1 DICER1 HNRNPA2B1

2.56e-051371511036244648
Pubmed

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.

TUBG2 SPTBN1 NUCB1 ACIN1 CLINT1 SSRP1 PAPSS1

2.84e-0560751739147351
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

TUBG2 CALU SPTBN1 CPD ADAM10 HNRNPA2B1 TUBG1

3.02e-0561351722268729
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

CALU RBM7 RBM5 ACIN1 PPHLN1 SSRP1 HNRNPA2B1 ELL

3.02e-0584751835850772
Pubmed

The CPLANE protein Fuzzy regulates ciliogenesis by suppressing actin polymerization at the base of the primary cilium via p190A RhoGAP.

TUBG2 TUBG1

3.15e-05651238546045
Pubmed

Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns.

VANGL2 VANGL1

3.15e-05651228599846
Pubmed

Genetic and molecular control of folate-homocysteine metabolism in mutant mice.

APC APOB

3.15e-05651212016514
Pubmed

Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor.

TUBG2 TUBG1

3.15e-05651230970247
Pubmed

Expression Analyses of Cep152, a Responsible Gene Product for Autosomal Recessive Primary Microcephaly, during Mouse Brain Development.

TUBG2 TUBG1

3.15e-05651235259752
Pubmed

Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein.

DNAI1 APC

3.15e-05651228057765
Pubmed

DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.

TUBG2 TUBG1

3.15e-05651222842144
Pubmed

Celsr1 coordinates the planar polarity of vestibular hair cells during inner ear development.

VANGL2 VANGL1

3.15e-05651228159525
Pubmed

Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis.

TUBG2 TUBG1

3.15e-05651229229864
Pubmed

Patterning of papillae on the mouse tongue: A system for the quantitative assessment of planar cell polarity signaling.

VANGL2 VANGL1

3.15e-05651227612405
Pubmed

Planar cell polarity governs the alignment of the nasopharyngeal epithelium in mammals.

VANGL2 VANGL1

3.15e-05651232452625
Pubmed

Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors.

VANGL2 VANGL1

3.15e-05651231974352
InteractionDPP4 interactions

VANGL2 HSPA12A CALU VANGL1 SPTBN1 NUCB1 CPD APOB ADAM10 HNRNPA2B1

1.37e-074535010int:DPP4
InteractionAFF1 interactions

PCSK1 ELL2 CPD ELL3 ELL

6.10e-0766505int:AFF1
InteractionIST1 interactions

BICD2 VPS9D1 FAM20C HNRNPA2B1 IQGAP3

3.56e-0694505int:IST1
InteractionPXN interactions

BICD2 TUBG2 APC CEP192 ADAM10 IQGAP3 TUBG1

1.75e-05334507int:PXN
InteractionRHOV interactions

VANGL2 VANGL1 SPTBN1 ZNF622 SSRP1 IQGAP3

2.95e-05243506int:RHOV
InteractionPRKACA interactions

VANGL2 CALU VANGL1 RASGRP3 SPTBN1 APC AKAP13 TUBG1

3.80e-05519508int:PRKACA
InteractionEPB41L3 interactions

VANGL2 HSPA12A VANGL1 SPTBN1 ACIN1 ADAM10

5.52e-05272506int:EPB41L3
InteractionYWHAH interactions

MTM1 SPTBN1 RBM7 APC AKAP13 PPHLN1 CEP192 CLINT1 MAP3K15 SSRP1 TUBG1

6.48e-0511025011int:YWHAH
InteractionRHOD interactions

VANGL2 HSPA12A VANGL1 SPTBN1 CPD CLINT1 SSRP1 IQGAP3

7.53e-05572508int:RHOD
InteractionACTR3 interactions

BICD2 CALU RASGRP3 APC CEP192 ADAM10

1.04e-04305506int:ACTR3
InteractionRPA4 interactions

BICD2 SPTBN1 APC RPRD2 CLINT1 SSRP1 HNRNPA2B1

1.18e-04452507int:RPA4
InteractionEAF2 interactions

ELL2 ELL3 ELL

1.23e-0439503int:EAF2
CytobandEnsembl 112 genes in cytogenetic band chr5q15

PCSK1 ELL2

1.99e-0359512chr5q15
Cytoband17q21

TUBG2 TUBG1

2.26e-036351217q21
GeneFamilyAF4/FMR2 family|Super elongation complex

ELL2 ELL3 ELL

5.06e-0793431280
GeneFamilyTubulins

TUBG2 TUBG1

1.08e-0326342778
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

APC CEP192 ELL

4.70e-03181343694
GeneFamilyRNA binding motif containing

RBM7 RBM5 HNRNPA2B1

7.37e-03213343725
GeneFamilyEF-hand domain containing

CALU RASGRP3 NUCB1

7.96e-03219343863
ToppCellBac-SEP-Lymphocyte-B-Plasmablast|Bac-SEP / Disease, Lineage and Cell Type

ELL2 CALU RASGRP3 PBK TUBG1

2.49e-061895156339b6d1056e07cefb0e1b2a0e479913c5783c8a
ToppCellSepsis-Bac-SEP-Lymphocyte-B-Plasmablast|Bac-SEP / Disease, condition lineage and cell class

ELL2 CALU RASGRP3 PBK TUBG1

3.13e-06198515614055c11d1dd2f3f2b8783ec35a8f4570cad161
ToppCellmild-Plasmablast|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ELL2 CALU RASGRP3 PBK TUBG1

3.13e-06198515b14b9e67815f93fac7bd8e5e6f1aa100951b4ac1
ToppCellControl-Lymphocyte-B-Plasmablast|Control / Disease, Lineage and Cell Type

FICD ELL2 RASGRP3 PBK

3.55e-0516251467b32c40cc180c5ebbfd901a417b5be469500110
ToppCellcontrol-Plasmablast|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ELL2 RASGRP3 PBK TUBG1

3.81e-0516551461063e0ce61bc92d5d1093be8279af03f650720b
ToppCellThalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Ebf1_(Anterior_pretectal_nucleus_(APT))-|Thalamus / BrainAtlas - Mouse McCarroll V32

APOB MYO15A ELL3

3.85e-0557513ef44602342511a9f90c93463628ad8b154cb26fb
ToppCellThalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Ebf1_(Anterior_pretectal_nucleus_(APT))|Thalamus / BrainAtlas - Mouse McCarroll V32

APOB MYO15A ELL3

3.85e-0557513a3dc14f7a63cc70b2789770644e0b9453426c6f9
ToppCelldroplet-Liver-LIVER_HEP|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPA12A RASGRP3 SPTBN1 NTN1

5.35e-05180514423454e3390080ae03bb3cbb267255ebfe4df080
ToppCelldroplet-Liver-LIVER_HEP-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPA12A RASGRP3 SPTBN1 NTN1

5.35e-05180514dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCellCOVID-19-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

ST6GALNAC3 RASGRP3 SPTBN1 ADAM10

5.95e-0518551436ce23893915f5c380cca39b2c33a516edf31c3a
ToppCellCOVID-19-Neuronal_cells-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

ST6GALNAC3 RASGRP3 SPTBN1 ADAM10

5.95e-051855144a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell(101)_plasma|World / immune cells in Peripheral Blood (logTPM normalization)

ELL2 RASGRP3 PBK TUBG1

6.07e-0518651416267994c9ef1fb7118c4c665cbc96979ec2b703
ToppCellCOVID-19_Mild-Lymphoid_P|COVID-19_Mild / Disease group, lineage and cell class

ELL2 CALU RASGRP3 PBK

6.46e-051895140b3d3bd697e79decae7e21c513fab9da3b2a47c5
ToppCellPBMC-Mild-Lymphocyte-B-Plasmablast-Plasmablast-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ELL2 CALU RASGRP3 PBK

6.46e-05189514c296660061b46e3abae1e7cf29df20274e5a8add
ToppCellPBMC-Mild-Lymphocyte-B-Plasmablast-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ELL2 CALU RASGRP3 PBK

6.46e-0518951473ee4cfb1057832f700be59b6917dedde3e89880
ToppCellCOVID-19_Mild-Lymphoid_P-Plasmablast|COVID-19_Mild / Disease group, lineage and cell class

ELL2 CALU RASGRP3 PBK

6.46e-05189514254f058850b41a5974a380f3710db7c01a51fb6b
ToppCellPBMC-Mild-Lymphocyte-B-Plasmablast-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ELL2 CALU RASGRP3 PBK

6.46e-0518951431594cc59eb1c5b01407dfd72b1487ecca8bf5ec
ToppCellPBMC-Mild-Lymphocyte-B-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ELL2 CALU RASGRP3 PBK

6.46e-05189514f2daf4889ef98bbefe3e44832618ac102a75b4d9
ToppCellPBMC-Mild-Lymphocyte-B-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

ELL2 CALU RASGRP3 PBK

6.46e-051895149de17ade3cc3e9cd1394338bd048fb1ce64ac50f
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CALU SPTBN1 CPD HNRNPA2B1

6.59e-05190514d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN1 APOB CLINT1 ADAM10

6.73e-0519151460c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCellCOVID-19_Moderate-Plasmablast|World / disease group, cell group and cell class

ELL2 CALU RASGRP3 PBK

6.73e-05191514bb28703020c5296b65527094d2e5924348275e58
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN1 APOB CLINT1 ADAM10

6.73e-0519151409db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN1 APOB CLINT1 ADAM10

6.73e-05191514973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellCOVID-19_Severe-Plasmablast|World / disease group, cell group and cell class

ELL2 CALU RASGRP3 PBK

6.87e-05192514a333053fe2bd206c32790916bfc5fce904ab7f57
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPA12A ST6GALNAC3 RASGRP3 SPTBN1

7.01e-05193514826b8dd801298b3e0cd76232feae5a14026b8806
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPA12A ST6GALNAC3 RASGRP3 SPTBN1

7.01e-0519351487d3a577d37fb0cb4b6313c596310de452bc3872
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPA12A ST6GALNAC3 RASGRP3 SPTBN1

7.01e-05193514d485634c564b268e344b6a2863c26f6adaec9e38
ToppCell(7)_Epithelial_cells-(7)_Epithelial-J_(AT1-AT2_progenitors)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

TRPC3 PBK IQGAP3 TUBG1

7.15e-051945144d6ae2b25db11a4ae6dadee83be5c8c05b1225c3
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_basal-Dividing_Basal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PBK KCNS1 APOB IQGAP3

7.15e-05194514d790cfff3664e46fe2fd2f6b0c26896799927845
ToppCell10x5'-lymph-node_spleen-Lymphocytic_B-GC_B_(I)|lymph-node_spleen / Manually curated celltypes from each tissue

PBK ELL3 IQGAP3 TUBG1

7.44e-0519651432d54c0b487f00c4f8bd765462e484da8a6625c9
ToppCell10x5'-GI_large-bowel-Lymphocytic_B-GC_B_(I)|GI_large-bowel / Manually curated celltypes from each tissue

PBK SSRP1 ELL3 IQGAP3

7.58e-0519751480a0cfbd454409594effead7082586b06c2f411a
ToppCellPBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast-Developping_Plasmablast|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ELL2 CALU PBK TUBG1

7.73e-051985142d8d4eb21b4fe3cc178b3518b3ea39c2d9650f24
ToppCellTransverse-(2)_B_cell-(21)_B_cell_IgG_Plasma|Transverse / shred on region, Cell_type, and subtype

ELL2 CALU RASGRP3 CLINT1

7.73e-05198514d6052b5a44246798e90f4779cd940ffac7539fcd
ToppCellTransverse-B_cell-B_cell_IgG_Plasma|Transverse / Region, Cell class and subclass

ELL2 CALU RASGRP3 CLINT1

7.73e-05198514a4ece1fe3d15acfde0e6ff14cddb3a3d16f61ce0
ToppCellsevere-Plasmablast|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ELL2 CALU RASGRP3 PBK

7.89e-051995146ee4c2e6049860071169366b7e662d5c1a3cc54b
ToppCellMild/Remission-Developping_Plasmablast|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ELL2 CALU PBK TUBG1

7.89e-0519951458c772ec763109a4009f52424fbb214fc23d0c09
ToppCell(5)_Plasmablast|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ELL2 CALU PBK TUBG1

7.89e-05199514f7d2ce4066436bbfe78150b579d22371a93ba76d
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-B-Plasmablast|COVID-19_Mild / Disease, condition lineage and cell class

ELL2 CALU RASGRP3 PBK

7.89e-0519951446f31aef26c3da7608082f750d743ad54adbc51a
ToppCellCOVID-19|World / Disease, condition lineage and cell class

KMT2C AKAP13 CLINT1 HNRNPA2B1

8.04e-052005147dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellSevere-Developping_Plasmablast|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ELL2 CALU PBK TUBG1

8.04e-052005146d0cd00e52568d23597cc2a4059bd967d7d2dab5
ToppCellSevere-Developping_Plasmablast|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ELL2 CALU PBK TUBG1

8.04e-0520051480639e0d2ddaae36ac7634a4f03e8809af7316e3
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KMT2C ACIN1 AKAP13 HNRNPA2B1

8.04e-0520051412f1685ce8f218433068e090c9d839cd5a1910bf
ToppCelllymphoid-T_cell-pro-T_cell|lymphoid / Lineage, cell class and subclass

MYO15A IFIT2 IQGAP3

1.93e-04985134da11182885d5f2673e85bd9c5717939b0268427
ToppCellClub_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

VANGL2 PBK IQGAP3

3.51e-041205137f85208f0455f3e634f8e7e81beea60b4ef1d2a5
ToppCellLPS-antiTNF-Unknown|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRPC3 PBK IQGAP3

4.34e-04129513739b263296c28554967362060b154f7a95e1341d
ToppCellLPS-antiTNF-Unknown-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRPC3 PBK IQGAP3

4.44e-04130513615c233c7c2600c1c2bc5cf5b1c501fc474564ef
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSRP1 IFIT2 IQGAP3

4.54e-04131513419a0a83b38eaea890d065c3f252ef83c2d37b5b
ToppCellLPS-antiTNF-Unknown-Endothelial-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRPC3 PBK IQGAP3

4.64e-0413251302491930097b75aaeedab9e8200711b0dc610944
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2|Hippocampus / BrainAtlas - Mouse McCarroll V32

PBK ACIN1 HNRNPA2B1

5.06e-041365133e13dc0634f3b05e9f9e6c3193f843f62e603b78
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4|Hippocampus / BrainAtlas - Mouse McCarroll V32

PBK ACIN1 HNRNPA2B1

5.06e-041365130185486c39700dd2f72d79be6d283494dd8379c9
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

VANGL2 PCSK1 ELL

5.17e-041375133f4746fb6fc36c90a8cd25725531a1503422cfbf
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAI1 NTN1 MYO15A

5.74e-04142513a05b320cf182b2aaf18df7c40045dc65b659bf20
ToppCellfacs-Heart-Unknown-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC3 MYO15A IQGAP3

5.74e-04142513759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCellLPS-IL1RA+antiTNF-Endothelial-Epi-like-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAI1 NTN1 MYO15A

5.74e-04142513d52da766e031f7409eb5a7a9fa88f48e14a79d8b
ToppCellLPS-antiTNF-Unknown-Endothelial-Monocytes-Macrophages|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNB3 PBK IFIT2

5.74e-04142513b66f9602dba30d1d4fbcc49ceb112eb5bd916ba1
ToppCellE16.5-samps|World / Age Group, Lineage, Cell class and subclass

PBK RBM5 SSRP1

6.60e-04149513e94d075f68c1c70c89fab50b1b765b5dda650d09
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB3 TUBG2 APOB

6.86e-04151513ea62e92ccb984f44559b434f35c1c4450767c8f1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ST6GALNAC3 RASGRP3 RBM7

7.40e-041555135d157478669b609e1f0f0a75afd0112571fc2c46
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PCSK1 FAM20C CPD

7.54e-04156513bb505f639dbcad2b788db62d6084c2cb4e884bec
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

APC APOB IFIT2

7.54e-04156513f5889a6899904dfb7f596600b3a76857cf9d5378
ToppCellIIF-Lymphocyte-B-Plasmablast|IIF / Disease, Lineage and Cell Type

ELL2 RASGRP3 PBK

8.26e-041615134d78985e7b11e92591e75a4864fd769882db2d1c
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ST6GALNAC3 NTN1 CLINT1

8.41e-041625135c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRPC3 PBK IQGAP3

8.56e-041635133efbbdc9cb2613bb76d8c2f07cd4ec1a2c51a622
ToppCellBasal_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

VANGL2 PCSK1 NTN1

8.71e-0416451385487a303194f5244956ec1ca2d1758d38117f41
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RASGRP3 TRPC3 NTN1

8.86e-04165513347b59aa625a8a960828b8620824d8ac48990e07
ToppCellPND03-Endothelial-Endothelial_lymphatic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RASGRP3 TRPC3 NTN1

8.86e-041655131890f9c33b0c5b381d57f97042da2610a093a6de
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RASGRP3 TRPC3 NTN1

8.86e-04165513507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RASGRP3 TRPC3 NTN1

8.86e-0416551339a25be081a5d59c7cf107a997d352793d5025fb
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PBK SSRP1 IQGAP3

8.86e-0416551388681101d7cf60b99b8ace5d8c0944323b937306
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ST6GALNAC3 RASGRP3 SPTBN1

8.86e-041655136a621b300442c52adfc15b61d3a6d3a3cb00099f
ToppCelldroplet-Skin-nan-18m-Epithelial-stem_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PBK CEP192 IQGAP3

8.86e-0416551396f0d8bc9b13e23f757e6bb98cd7dc061a8a9564
ToppCell3'-Adult-LargeIntestine-Epithelial-mature_enterocytic-Paneth|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK1 APOB HNRNPA2B1

9.02e-04166513b64ab3d13b76bba3c305ebbfc96f983cd6ca30c9
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RASGRP3 TRPC3 NTN1

9.50e-04169513f077e39e41fffe7672541f5b72b80faaf56c597c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ST6GALNAC3 RASGRP3 SPTBN1

9.50e-04169513987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASGRP3 ADAM10 IFIT2

9.50e-041695134e1322cc5e1733e9fb19e08f739a30206f43cea8
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ST6GALNAC3 RASGRP3 NTN1

9.66e-04170513dcc64b73134e89ae37990d4878813b86ce91dae9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PBK SSRP1 TUBG1

9.66e-0417051321bfe070e63722672176052b386167ea4c3dc4e5
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ST6GALNAC3 RASGRP3 NTN1

9.66e-041705136035c92cd39c5ac54e7ec57d94888ee19f574639
ToppCelldroplet-Fat-Bat-18m|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 DNAI1 TUBG2

9.66e-04170513c720d81bc29a8fd1f1249c6af408471d561f1d5d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ST6GALNAC3 RASGRP3 NTN1

9.66e-04170513c8c42eda44b61440c96b202e7f54650046eb95d3
ToppCelldroplet-Fat-Bat|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 DNAI1 TUBG2

9.66e-04170513c4ecdfc2b4710da0a5fbb20e9df02536023badb1
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PBK MAP3K15 IQGAP3

9.83e-04171513913bae728b5e653771a27c79a309eb023699f1d0
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PBK MAP3K15 IQGAP3

9.83e-04171513f28b2336057e353b96a6ff4581ec9fd0ca0789d9
ToppCellPND28-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAP3K15 ARMH3 ELL

9.99e-04172513eba1568d4307e91c94fc616549057cbed8df5840
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Npnt_(Retrosplenial_areas,_layer_5,_Npnt+)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

APOB MYO15A

1.00e-0341512b1e70962de91a747ec718a3fad4247fd0cb7d9a8
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Npnt_(Retrosplenial_areas,_layer_5,_Npnt+)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

APOB MYO15A

1.00e-034151216dbb13baa47c4db80ddd83ac36aad6c43b5461a
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC3 RASGRP3 TRPC3

1.02e-031735130b79e2a4fd19d524c24b69a6b524ffc6affdabe5
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D122|Adult / Lineage, Cell type, age group and donor

ST6GALNAC3 RASGRP3 NTN1

1.02e-03173513dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC3 RASGRP3 TRPC3

1.02e-03173513a2c1ef3f4d7e9f68fc77ee7c42a4727bdea5da94
ToppCell5'-Adult-Appendix-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FICD ELL2 RASGRP3

1.02e-0317351368bcc0eee15df9cf3516c641709154301bd7b38f
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC3 RASGRP3 TRPC3

1.02e-031735134830136f1f1976e00ac9af9062a531ac42533041
ToppCellHealthy-Plasmablast|World / disease group, cell group and cell class

ELL2 RASGRP3 PBK

1.03e-031745136becb456d8f44a1224c6d42be78d4c8cdb51f199
ToppCellMultiple_Sclerosis-Lymphocyte-B-Plasmablast|Multiple_Sclerosis / Disease, Lineage and Cell Type

ELL2 RASGRP3 PBK

1.03e-03174513e8d2aa9505817aac3fe068080774d19458f07b01
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_B-B_plasma-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

FICD ELL2 RASGRP3

1.03e-03174513bdbaf805a94b2f5a0065933dab6bf84e3cabd525
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VANGL1 PBK IQGAP3

1.05e-031755139142ed8ca2f1c0c518deb21988221406f62fe38c
ToppCell368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|368C / Donor, Lineage, Cell class and subclass (all cells)

VANGL1 PBK IQGAP3

1.05e-0317551374800a10f5ff25d5414fbccb0668f92ff077d1cc
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P5-P5_1-Sox4|Striatum / BrainAtlas - Mouse McCarroll V32

PBK HNRNPA2B1 IQGAP3

1.07e-03176513d70fdc7bc48719776ed1e7c01118385e3a21623f
ToppCellControl-Neuronal_cells|Control / group, cell type (main and fine annotations)

ST6GALNAC3 RASGRP3 NTN1

1.07e-03176513c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P5-P5_1|Striatum / BrainAtlas - Mouse McCarroll V32

PBK HNRNPA2B1 IQGAP3

1.07e-03176513a84361308e5e96f3a30246cd29e109c321ee65bf
DrugAC1L9N9H

DNAI1 CALU NUCB1 PBK APC

8.07e-0777515CID000449572
Drugacetochlor

VANGL2 FICD VANGL1 APOB

1.56e-0638514CID000001988
Drugtrifluoperazine dihydrochloride; Up 200; 10uM; HL60; HT_HG-U133A

FICD CALU SPTBN1 RBM5 AKAP13 IFIT2

4.37e-061925161165_UP
Drugcopper(II) sulfate pentahydrate; Up 200; 100uM; ssMCF7; HG-U133A

HSPA12A SPTBN1 RBM5 CPD IFIT2 ELL

5.21e-06198516500_UP
DrugCloperastine hydrochloride [14984-68-0]; Down 200; 11uM; PC3; HT_HG-U133A

BICD2 SPTBN1 RBM5 CPD DICER1

6.44e-051895154271_DN
DrugFlupentixol dihydrochloride cis-(Z) [2413-38-9]; Down 200; 7.8uM; HL60; HT_HG-U133A

CALU RBM5 AKAP13 ADAM10 DICER1

6.44e-051895151288_DN
DrugButamben [94-25-7]; Down 200; 20.6uM; PC3; HT_HG-U133A

TUBG2 MTM1 SPTBN1 AKAP13 IFIT2

6.77e-051915155792_DN
DrugHomochlorcyclizine dihydrochloride [1982-36-1]; Up 200; 10.4uM; MCF7; HT_HG-U133A

HSPA12A SPTBN1 KCNS1 AKAP13 MYO15A

6.77e-051915157417_UP
DrugCarbarsone [121-59-5]; Down 200; 15.4uM; MCF7; HT_HG-U133A

BICD2 CACNB3 HSPA12A APC AKAP13

6.94e-051925154110_DN
DrugAjmaline [4360-12-7]; Down 200; 12.2uM; HL60; HG-U133A

BICD2 NADSYN1 CALU CLINT1 ARMH3

7.11e-051935151749_DN
DrugFuraltadone hydrochloride [3759-92-0]; Down 200; 11uM; MCF7; HT_HG-U133A

CACNB3 CALU APC ADAM10 DICER1

7.29e-051945153932_DN
DrugChlortetracycline hydrochloride [64-72-2]; Down 200; 7.8uM; HL60; HG-U133A

BICD2 NADSYN1 CALU AKAP13 ARMH3

7.29e-051945152042_DN
DrugEtidronic acid, disodium salt [7414-83-7]; Down 200; 16uM; MCF7; HT_HG-U133A

MTM1 SPTBN1 APC CPD ADAM10

7.29e-051945154387_DN
Drug2,4-di-tert-butylphenol

APOB CLINT1

7.34e-056512CID000007311
Drugdibromosulphthalein

ACIN1 APOB

7.34e-056512CID000086995
DrugEtofenamate [30544-47-9]; Down 200; 10.8uM; MCF7; HT_HG-U133A

HSPA12A SPTBN1 KCNS1 AKAP13 CPD

7.65e-051965154108_DN
DrugC75; Down 200; 10uM; PC3; HT_HG-U133A

TUBG2 MTM1 SPTBN1 APC ELL

7.84e-051975156428_DN
DrugIvermectin [70288-86-7]; Up 200; 4.6uM; PC3; HT_HG-U133A

HSPA12A CALU MTM1 AKAP13 IFIT2

7.84e-051975152051_UP
DrugGentamicine sulfate [1405-41-0]; Down 200; 2.6uM; PC3; HT_HG-U133A

MTM1 RBM5 AKAP13 CPD ARMH3

7.84e-051975152082_DN
DrugKetorolac tromethamine [74103-07-4]; Down 200; 10.6uM; MCF7; HT_HG-U133A

NUCB1 APC KCNS1 CPD CLINT1

8.03e-051985156489_DN
DrugNomegestrol acetate [58652-20-3]; Down 200; 10.8uM; MCF7; HT_HG-U133A

CALU SPTBN1 KCNS1 CPD ADAM10

8.03e-051985156525_DN
DrugChlorhexidine [55-56-1]; Down 200; 8uM; PC3; HT_HG-U133A

TUBG2 RBM5 AKAP13 CPD ARMH3

8.03e-051985156302_DN
DrugTolmetin sodium salt dihydrate [64490-92-2]; Down 200; 12.6uM; MCF7; HT_HG-U133A

VPS9D1 HSPA12A MTM1 SPTBN1 APC

8.03e-051985153347_DN
DrugAdrenosterone [382-45-6]; Down 200; 13.4uM; MCF7; HT_HG-U133A

HSPA12A TUBG2 NUCB1 APC KCNS1

8.03e-051985156486_DN
DrugTrapidil [15421-84-8]; Down 200; 19.4uM; MCF7; HT_HG-U133A

MTM1 NUCB1 KCNS1 AKAP13 RPRD2

8.03e-051985156515_DN
DrugRanitidine hydrochloride [66357-59-3]; Down 200; 11.4uM; PC3; HT_HG-U133A

MTM1 NUCB1 ACIN1 AKAP13 ARMH3

8.22e-051995156324_DN
DrugSC-560; Up 200; 10uM; MCF7; HT_HG-U133A

PCSK1 VPS9D1 MTM1 SPTBN1 CPD

8.22e-051995156870_UP
DrugNorcyclobenzaprine [303-50-4]; Down 200; 15.4uM; MCF7; HT_HG-U133A

SPTBN1 NUCB1 APC AKAP13 ARMH3

8.22e-051995152830_DN
DrugAC1L8GZ1

CALU CLINT1 TUBG1

9.87e-0540513CID000381235
DrugAC1L3VO5

CLINT1 ELL3 ELL TUBG1

1.33e-04116514CID000123015
Diseasecomplex cortical dysplasia with other brain malformations 4 (implicated_via_orthology)

TUBG2 TUBG1

2.70e-062492DOID:0090138 (implicated_via_orthology)
DiseaseNeural tube defect

VANGL2 VANGL1

2.69e-055492cv:C0027794
DiseaseSpina bifida aperta of cervical spine

VANGL2 VANGL1

4.04e-056492C1960883
DiseaseSacral agenesis

VANGL2 VANGL1

5.64e-057492C0344490
Diseaseneural tube defect (is_implicated_in)

VANGL2 VANGL1

7.52e-058492DOID:0080074 (is_implicated_in)
DiseaseNEURAL TUBE DEFECTS, SUSCEPTIBILITY TO

VANGL2 VANGL1

7.52e-058492C3891448
Diseaseneural tube defect (implicated_via_orthology)

VANGL2 VANGL1

9.65e-059492DOID:0080074 (implicated_via_orthology)
Diseaserheumatoid arthritis (implicated_via_orthology)

KMT2C HNRNPA2B1

1.76e-0412492DOID:7148 (implicated_via_orthology)
Diseasegallbladder cancer (is_implicated_in)

APC APOB

2.08e-0413492DOID:3121 (is_implicated_in)
DiseaseLipidemias

APC APOB

3.62e-0417492C1706412
DiseaseHyperlipidemia

APC APOB

3.62e-0417492C0020473
Diseaseaortic measurement

PCSK1 ELL2 RPRD2 ELL

8.02e-04251494EFO_0020865
DiseaseIniencephaly

VANGL2 VANGL1

9.93e-0428492C0152234
DiseaseTethered Cord Syndrome

VANGL2 VANGL1

9.93e-0428492C0080218
DiseaseSpinal Cord Myelodysplasia

VANGL2 VANGL1

9.93e-0428492C0344479
DiseaseExencephaly

VANGL2 VANGL1

9.93e-0428492C0266453
DiseaseNeurenteric Cyst

VANGL2 VANGL1

9.93e-0428492C0027806
DiseaseAcrania

VANGL2 VANGL1

9.93e-0428492C0702169
DiseaseDiastematomyelia

VANGL2 VANGL1

9.93e-0428492C0011999
DiseaseCraniorachischisis

VANGL2 VANGL1

1.07e-0329492C0152426
DiseaseNeural Tube Defects

VANGL2 VANGL1

1.14e-0330492C0027794

Protein segments in the cluster

PeptideGeneStartEntry
RDSSHNELYYEEAEH

VANGL1

336

Q8TAA9
NSHNEYYYEEAEHER

VANGL2

336

Q9ULK5
FLCADYAEQDELDYH

ACIN1

1081

Q9UKV3
DDFNAEYDEYRALHA

ELL2

546

O00472
HAYEQDFETDYAEYR

ELL3

301

Q9HB65
KNDFNAEYSEYRDLH

ELL

526

P55199
DNEKDRDSHEDGDYY

BICD2

411

Q8TD16
RDSHEDGDYYEVDIN

BICD2

416

Q8TD16
SSRHLEEDYADAYQD

CACNB3

421

P54284
DYCLAYVFTDRDFDD

ADAM10

311

O14672
EEDFHFVQDEAYDAA

AKAP13

86

Q12802
DQYERYSEQHKEAAF

ARMH3

641

Q5T2E6
SDYDHAEAEARHLVY

CALU

261

O43852
DDIAQDFKYYDDAAD

DNAI1

296

Q9UI46
ADYEDDFLEYDQEHI

DICER1

1436

Q9UPY3
NEDDSELARDSYFYA

NTN1

261

O95631
ELCYDYKFDFEDDQH

KMT2C

4881

Q8NEZ4
YDLRSLENYHFVDEH

CLINT1

106

Q14677
DGDDYYDRQSLHRYE

MYO15A

241

Q9UKN7
RSDYYHVLEAANEGD

FICD

396

Q9BVA6
LCDDYDEAAREFYFD

KCNS1

91

Q96KK3
YAARDFYHDLDPNEA

HSPA12A

116

O43301
AQYDAAHHEEFKRYE

NUCB1

166

Q02818
DYGEHDYRHDISDER

RBM5

81

P52756
HDDRESQDIYDHYLT

IQGAP3

266

Q86VI3
RMDYYDSEHHEDFEF

PAPSS1

571

O43252
HRDFSAEYEEDGKYE

APOB

3951

P04114
YFSDYERHNAEIAAF

FAM20C

301

Q8IXL6
EDSHEEDDFLYVAYS

GABARAPL3

96

Q9BY60
AEGQFDRYYHEEELE

CPD

51

O75976
ASLHALADQYEDAEY

IFIT2

341

P09913
DIDDEMFYDDHLEAY

CEP192

216

Q8TEP8
SFQEDEDYRDFEYSG

RPRD2

826

Q5VT52
VDYRDYDEGRSFSHD

PPHLN1

56

Q8NEY8
DQDDAALEHFDRYFL

FTH1P19

6

P0C7X4
DTLEYEYDHDANGER

MAP3K15

641

Q6ZN16
FYEDRNHDDWSHDYD

RBM7

236

Q9Y580
NYDHDHDGYISQEDF

RASGRP3

431

Q8IV61
YEQGRDECDEYFLHE

ST6GALNAC3

256

Q8NDV1
YADSDEDQHDAYLER

SSRP1

441

Q08945
AHRAQQYYFDAAEAE

SPTBN1

1591

Q01082
YGDYVFDTNRHDDNR

APC

796

P25054
ESDDAYHNAELFFLD

MTM1

296

Q13496
EDTEEHHLRDYFEEY

HNRNPA2B1

121

P22626
DRKDVFFYQADDEHY

TUBG1

46

P23258
FDESDFDDEAYYAAL

PBK

261

Q96KB5
DRKDVFFYQADDEHY

TUBG2

46

Q9NRH3
DGDAALEFADFYDFR

ZNF622

336

Q969S3
RALYAAILEYEQDHD

VPS9D1

236

Q9Y2B5
QDDDFYAYDEDGTRF

TRPC3

131

Q13507
AYHAENYSPEDNRFD

NADSYN1

656

Q6IA69
YDPEASYDFNDNDHD

PCSK1

181

P29120