Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	signaling receptor complex adaptor activity	DLG5 NCK1 MAGI2 G3BP2 NCK2	3.07e-05	54	134	5	GO:0030159
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	ERCC6L CHD9 CHD2 CHD7	1.08e-04	37	134	4	GO:0140658
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	KCNA1 SCN1A SCN2A	1.88e-04	17	134	3	GO:0099508
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	ERCC6L CHD9 CHD2 CHD7 MCM9 CDK7	2.17e-04	127	134	6	GO:0008094
GeneOntologyMolecularFunction	ATP-dependent activity	MYO1D ERCC6L CHD9 CHD2 CHD7 SMC5 MDN1 DNAH17 MCM9 DYNC1LI1 MTREX DNAH8 CDK7	2.55e-04	614	134	13	GO:0140657
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE6A PDE1B PDE6B	4.14e-04	22	134	3	GO:0004115
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE6A PDE1B PDE6B	5.39e-04	24	134	3	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE6A PDE1B PDE6B	6.10e-04	25	134	3	GO:0004114
GeneOntologyMolecularFunction	alkali metal ion binding	CPS1 SCN1A SCN2A	6.86e-04	26	134	3	GO:0031420
GeneOntologyMolecularFunction	helicase activity	ERCC6L CHD9 CHD2 CHD7 MCM9 MTREX	6.96e-04	158	134	6	GO:0004386
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE6A PDE1B PDE6B	7.68e-04	27	134	3	GO:0004112
GeneOntologyCellularComponent	cilium	ADCY10 SPATA7 DLG5 ARL2BP PDE6A PDE6B CEP162 BBS2 FAM161B SNTN CC2D2B MAGI2 AKAP9 TIAM1 DNAH17 DNAH8	2.27e-04	898	135	16	GO:0005929
GeneOntologyCellularComponent	main axon	MYO1D KCNA1 TIAM1 SCN1A SCN2A	2.80e-04	89	135	5	GO:0044304
GeneOntologyCellularComponent	microtubule organizing center	SPATA7 FLII DLG5 ARL2BP VPS37A CEP162 BBS2 BCCIP PPP4R3A MAGI2 NEK1 AKAP9 TIAM1 KIAA1217 DYNC1LI1 PRKCB	2.94e-04	919	135	16	GO:0005815
GeneOntologyCellularComponent	extrinsic component of postsynaptic membrane	MAGI2 AKAP9 TIAM1	3.71e-04	22	135	3	GO:0098890
GeneOntologyCellularComponent	centrosome	FLII ARL2BP VPS37A CEP162 BBS2 BCCIP PPP4R3A MAGI2 NEK1 AKAP9 TIAM1 KIAA1217 DYNC1LI1 PRKCB	4.67e-04	770	135	14	GO:0005813
MousePheno	decreased paired-pulse ratio	RYR2 KCNA1 SCN1A	1.78e-06	4	108	3	MP:0014253
MousePheno	abnormal paired-pulse ratio	RYR2 KCNA1 SCN1A	1.53e-05	7	108	3	MP:0014252
Domain	Dishevelled	DVL1P1 DVL1 DVL3	1.37e-06	4	132	3	PF02377
Domain	Dishevelled_fam	DVL1P1 DVL1 DVL3	1.37e-06	4	132	3	IPR008339
Domain	Dishevelled_protein_dom	DVL1P1 DVL1 DVL3	1.37e-06	4	132	3	IPR003351
Domain	DIX	DVL1P1 DVL1 DVL3	1.18e-05	7	132	3	PF00778
Domain	DIX	DVL1P1 DVL1 DVL3	1.18e-05	7	132	3	IPR001158
Domain	DIX	DVL1P1 DVL1 DVL3	1.18e-05	7	132	3	PS50841
Domain	DAX	DVL1P1 DVL1 DVL3	1.18e-05	7	132	3	SM00021
Domain	DVL-1	DVL1P1 DVL1	4.96e-05	2	132	2	IPR008340
Domain	NCK	NCK1 NCK2	4.96e-05	2	132	2	IPR017304
Domain	SNF2_N	ERCC6L CHD9 CHD2 CHD7	7.35e-05	32	132	4	IPR000330
Domain	SNF2_N	ERCC6L CHD9 CHD2 CHD7	7.35e-05	32	132	4	PF00176
Domain	PDZ	DLG5 DVL1P1 DVL1 DVL3 MAGI2 TIAM1 RHPN2	8.78e-05	148	132	7	SM00228
Domain	PDZ	DLG5 DVL1P1 DVL1 DVL3 MAGI2 TIAM1 RHPN2	9.96e-05	151	132	7	PS50106
Domain	P-loop_NTPase	TANC2 ADCY10 DLG5 MYO1D ERCC6L CHD9 CHD2 CHD7 SMC5 MAGI2 ARHGAP5 MDN1 MCM9 DYNC1LI1 MTREX DNAH8 MX1	1.01e-04	848	132	17	IPR027417
Domain	PDZ	DLG5 DVL1P1 DVL1 DVL3 MAGI2 TIAM1 RHPN2	1.04e-04	152	132	7	IPR001478
Domain	Dishevelled_C-dom	DVL1 DVL3	1.48e-04	3	132	2	IPR024580
Domain	Dsh_C	DVL1 DVL3	1.48e-04	3	132	2	PF12316
Domain	-	RASA4 RASA4B	1.48e-04	3	132	2	4.10.1130.10
Domain	Mod_r	VPS37C VPS37A	2.95e-04	4	132	2	PF07200
Domain	Mod_r	VPS37C VPS37A	2.95e-04	4	132	2	IPR009851
Domain	Dsh/Dvl-rel	DVL1 DVL3	2.95e-04	4	132	2	IPR015506
Domain	VPS37_C	VPS37C VPS37A	2.95e-04	4	132	2	PS51314
Domain	PDEase	PDE6A PDE1B PDE6B	3.08e-04	19	132	3	IPR023088
Domain	Rho_GTPase_activation_prot	CHN1 ARHGAP5 PLXNC1 RASA4 RASA4B	4.00e-04	88	132	5	IPR008936
Domain	PDEase_I	PDE6A PDE1B PDE6B	4.18e-04	21	132	3	PF00233
Domain	PDEASE_I	PDE6A PDE1B PDE6B	4.18e-04	21	132	3	PS00126
Domain	PDEase_CS	PDE6A PDE1B PDE6B	4.18e-04	21	132	3	IPR023174
Domain	DEP	DVL1P1 DVL1 DVL3	4.82e-04	22	132	3	PF00610
Domain	DEP	DVL1P1 DVL1 DVL3	4.82e-04	22	132	3	PS50186
Domain	-	PDE6A PDE1B PDE6B	4.82e-04	22	132	3	1.10.1300.10
Domain	DEP	DVL1P1 DVL1 DVL3	4.82e-04	22	132	3	SM00049
Domain	PDZ	DLG5 DVL1P1 DVL1 DVL3 MAGI2 TIAM1	5.00e-04	141	132	6	PF00595
Domain	DEP_dom	DVL1P1 DVL1 DVL3	5.51e-04	23	132	3	IPR000591
Domain	PDEase_catalytic_dom	PDE6A PDE1B PDE6B	5.51e-04	23	132	3	IPR002073
Domain	HD/PDEase_dom	PDE6A PDE1B PDE6B	6.26e-04	24	132	3	IPR003607
Domain	HDc	PDE6A PDE1B PDE6B	6.26e-04	24	132	3	SM00471
Domain	Chromo_domain	CHD9 CHD2 CHD7	6.26e-04	24	132	3	IPR023780
Domain	-	TANC2 ADCY10 ERCC6L TTC16 TANC1 ANAPC5 FKBP5	6.80e-04	207	132	7	1.25.40.10
Domain	TPR-contain_dom	TANC2 ERCC6L TTC16 TANC1 ANAPC5 FKBP5	6.93e-04	150	132	6	IPR013026
Domain	-	DLG5 DVL1 DVL3 MAGI2 TIAM1 RHPN2	6.93e-04	150	132	6	2.30.42.10
Domain	Channel_four-helix_dom	KCNA1 KCNA10 SCN1A SCN2A	7.05e-04	57	132	4	IPR027359
Domain	-	KCNA1 KCNA10 SCN1A SCN2A	7.05e-04	57	132	4	1.20.120.350
Domain	BRK	CHD9 CHD7	7.30e-04	6	132	2	SM00592
Domain	Na_trans_cytopl	SCN1A SCN2A	7.30e-04	6	132	2	PF11933
Domain	BRK_domain	CHD9 CHD7	7.30e-04	6	132	2	IPR006576
Domain	Na_trans_cytopl	SCN1A SCN2A	7.30e-04	6	132	2	IPR024583
Domain	BRK	CHD9 CHD7	7.30e-04	6	132	2	PF07533
Domain	Chromo	CHD9 CHD2 CHD7	7.97e-04	26	132	3	PF00385
Domain	-	ADCY10 DLG5 ERCC6L CHD9 CHD2 CHD7 SMC5 ARHGAP5 MDN1 MCM9 DYNC1LI1 MTREX DNAH8 MX1	8.18e-04	746	132	14	3.40.50.300
Domain	Helicase_C	ERCC6L CHD9 CHD2 CHD7 MTREX	9.76e-04	107	132	5	PF00271
Domain	HELICc	ERCC6L CHD9 CHD2 CHD7 MTREX	9.76e-04	107	132	5	SM00490
Domain	CHROMO_1	CHD9 CHD2 CHD7	9.93e-04	28	132	3	PS00598
Domain	CHROMO_2	CHD9 CHD2 CHD7	9.93e-04	28	132	3	PS50013
Domain	GAF	PDE6A PDE6B	1.02e-03	7	132	2	PF01590
Domain	Helicase_C	ERCC6L CHD9 CHD2 CHD7 MTREX	1.02e-03	108	132	5	IPR001650
Domain	HELICASE_CTER	ERCC6L CHD9 CHD2 CHD7 MTREX	1.06e-03	109	132	5	PS51194
Domain	HELICASE_ATP_BIND_1	ERCC6L CHD9 CHD2 CHD7 MTREX	1.06e-03	109	132	5	PS51192
Domain	DEXDc	ERCC6L CHD9 CHD2 CHD7 MTREX	1.06e-03	109	132	5	SM00487
Domain	Helicase_ATP-bd	ERCC6L CHD9 CHD2 CHD7 MTREX	1.11e-03	110	132	5	IPR014001
Domain	TPR_REGION	TANC2 ERCC6L TTC16 TANC1 ANAPC5 FKBP5	1.14e-03	165	132	6	PS50293
Domain	TPR	TANC2 ERCC6L TTC16 TANC1 ANAPC5 FKBP5	1.14e-03	165	132	6	PS50005
Domain	Ion_trans_dom	RYR2 KCNA1 KCNA10 SCN1A SCN2A	1.30e-03	114	132	5	IPR005821
Domain	Ion_trans	RYR2 KCNA1 KCNA10 SCN1A SCN2A	1.30e-03	114	132	5	PF00520
Domain	GAF	PDE6A PDE6B	1.35e-03	8	132	2	IPR003018
Domain	K_chnl_volt-dep_Kv1	KCNA1 KCNA10	1.35e-03	8	132	2	IPR003972
Domain	GAF	PDE6A PDE6B	1.35e-03	8	132	2	SM00065
Domain	TPR-like_helical_dom	TANC2 ADCY10 ERCC6L TTC16 TANC1 ANAPC5 FKBP5	1.35e-03	233	132	7	IPR011990
Domain	Chromodomain-like	CHD9 CHD2 CHD7	1.47e-03	32	132	3	IPR016197
Domain	Chromo/shadow_dom	CHD9 CHD2 CHD7	1.61e-03	33	132	3	IPR000953
Domain	CHROMO	CHD9 CHD2 CHD7	1.61e-03	33	132	3	SM00298
Domain	BTK	RASA4 RASA4B	1.73e-03	9	132	2	SM00107
Domain	-	PDE6A PDE6B	1.73e-03	9	132	2	3.30.450.40
Domain	Znf_Btk_motif	RASA4 RASA4B	1.73e-03	9	132	2	IPR001562
Domain	GAF_dom-like	PDE6A PDE6B	1.73e-03	9	132	2	IPR029016
Domain	BTK	RASA4 RASA4B	1.73e-03	9	132	2	PF00779
Domain	ZF_BTK	RASA4 RASA4B	1.73e-03	9	132	2	PS51113
Domain	Na_channel_asu	SCN1A SCN2A	2.15e-03	10	132	2	IPR001696
Domain	Na_trans_assoc	SCN1A SCN2A	2.15e-03	10	132	2	IPR010526
Domain	Na_trans_assoc	SCN1A SCN2A	2.15e-03	10	132	2	PF06512
Domain	TPR	TANC2 TTC16 TANC1 ANAPC5 FKBP5	2.23e-03	129	132	5	SM00028
Domain	C2	RASA4 PLA2G4B PRKCB RASA4B UNC13C	2.39e-03	131	132	5	PF00168
Domain	TPR_repeat	TANC2 TTC16 TANC1 ANAPC5 FKBP5	2.55e-03	133	132	5	IPR019734
Domain	C2	RASA4 PLA2G4B PRKCB RASA4B UNC13C	2.90e-03	137	132	5	SM00239
Domain	C2	RASA4 PLA2G4B PRKCB RASA4B UNC13C	3.38e-03	142	132	5	PS50004
Domain	-	RASA4 PLA2G4B PRKCB RASA4B UNC13C	4.04e-03	148	132	5	2.60.40.150
Domain	RasGAP	RASA4 RASA4B	4.27e-03	14	132	2	SM00323
Domain	ATPase_dyneun-rel_AAA	MDN1 DNAH8	4.27e-03	14	132	2	IPR011704
Domain	RasGAP_CS	RASA4 RASA4B	4.27e-03	14	132	2	IPR023152
Domain	AAA_5	MDN1 DNAH8	4.27e-03	14	132	2	PF07728
Domain	RasGAP	RASA4 RASA4B	4.90e-03	15	132	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA4 RASA4B	4.90e-03	15	132	2	PS00509
Domain	RAS_GTPASE_ACTIV_2	RASA4 RASA4B	4.90e-03	15	132	2	PS50018
Domain	-	RASA4 RASA4B	5.58e-03	16	132	2	1.10.506.10
Domain	C2_dom	RASA4 PLA2G4B PRKCB RASA4B UNC13C	6.21e-03	164	132	5	IPR000008
Domain	RasGAP_dom	RASA4 RASA4B	7.04e-03	18	132	2	IPR001936
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TANC2 PDE6A MYO1D ERCC6L CALU VPS33A MAML1 CHD2 CHD7 RYR2 MDN1 GUCY1B2 PPT1 G3BP2 KDM2B SMCR8	5.78e-09	638	138	16	31182584
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	TANC2 PITPNM2 FLII FAM120B VWF ACADL MYO1D HNRNPF ARPC2 MAGI2 ARHGAP5 KCNA1 LRIG1 SPON1 KIAA1217 G3BP2 SCN2A PRKCB TANC1 ALB HADHA RPL10 NCK2	1.11e-08	1431	138	23	37142655
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	FLII DLG5 MYO1D CALU POLR2H DVL1 DVL3 CHD9 API5 HNRNPF ARPC2 AKAP9 PPT1 FDPS G3BP2 KDM2B HADHA MTREX FKBP5 PCID2 RPL10	2.36e-08	1247	138	21	27684187
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TANC2 PITPNM2 VPS37C FLII ACADL VPS33A DVL1 DVL3 RYR2 MAGI2 KCNA1 FDPS SCN1A KIAA1217 G3BP2 DYNC1LI1 PRKCB HADHA RPL10	1.36e-07	1139	138	19	36417873
Pubmed	cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.	DVL1P1 DVL1 DVL3	2.44e-07	4	138	3	8817329
Pubmed	Human dishevelled genes constitute a DHR-containing multigene family.	DVL1P1 DVL1 DVL3	2.44e-07	4	138	3	9192851
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CUL4B FLII ERCC6L UFL1 CHD7 ZNF224 HNRNPF PPP4R3A MDN1 SENP6 KDM2B DYNC1LI1 YY1AP1 ANAPC5 FKBP5	4.92e-07	774	138	15	15302935
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	DLG5 MYO1D MAML1 CHD7 PPP4R3A KIAA1217 SENP6 KDM2B YY1AP1 TANC1 MTREX FKBP5 NCK2	6.94e-07	588	138	13	38580884
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	FAM120B MYO1D ERCC6L CEP162 POLR2H BCCIP UFL1 PPP4R3A ARPC2 MAGI2 IBTK TIAM1 RHPN2 G3BP2 PYGM HADHA MTREX EDEM1 PCID2	8.32e-07	1284	138	19	17353931
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PITPNM2 DLG5 CEP162 MAML1 UFL1 IBTK FDPS SENP6 KDM2B MTREX EDEM1 USP6NL	1.46e-06	529	138	12	14621295
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TANC2 FLII PDE1B ARHGEF18 CHD7 TMEM132B ARPC2 LRIG2 MAGI2 KCNA1 MDN1 AKAP9 TMEM259 KIAA1217 G3BP2 PRKCB	1.51e-06	963	138	16	28671696
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TANC2 DLG5 CDC42EP4 ERCC6L CALU CEP162 POLR1F NEK1 MDN1 AKAP9 TIAM1 KIAA1217 TANC1 MTREX USP6NL	1.84e-06	861	138	15	36931259
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ERCC6L GPAM HNRNPF IBTK RHPN2 YY1AP1 TANC1 MTREX EDEM1 SLC12A7 RIOK2 ANAPC5 COG4	2.10e-06	650	138	13	38777146
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	MYO1D UFL1 LRIG2 AKAP9 SPON1 SENP6	3.25e-06	101	138	6	9872452
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FLII VWF ZNF473 DVL3 CHD9 NCK1 DNAAF9 ZNF224 HNRNPF FAN1 MAGI2 ARHGAP5 PPT1 TIAM1 CHMP3 SENP6 YY1AP1 COG4	3.57e-06	1285	138	18	35914814
Pubmed	An inter-species protein-protein interaction network across vast evolutionary distance.	CUL4B ZC3H12A ZNF473 ERCC6L CALU DVL3 CAGE1 TIFA UPP2 MX1 NCK2	3.91e-06	483	138	11	27107014
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	TMPRSS15 POLR2H DVL3 BCCIP UFL1 CHD2 CHD7 HNRNPF POLR1F MDN1 PRKCB ALB HADHA MTREX RIOK2 FKBP5 PCID2 RPL10	5.07e-06	1318	138	18	30463901
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CUL4B ERCC6L MAML1 BCCIP ARHGEF18 NCK1 CHD7 IBTK DYNC1LI1 TANC1 COG4 FKBP5 NCK2	7.69e-06	733	138	13	34672954
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	FLII CALU VPS33A POLR2H CHD9 CHD2 MDN1 DYNC1LI1 ANAPC5 PCID2 CDK7	9.87e-06	533	138	11	30554943
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	KCNA1 PLXNC1 SCN1A PYGM TANC1 RPL10 NCK2	1.46e-05	197	138	7	36604605
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	FLII VWF SMC5 NSRP1 HNRNPF PPT1 KIAA1217 MMRN2 DYNC1LI1	1.47e-05	360	138	9	33111431
Pubmed	The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.	CUL4B PDE6B DVL1 DVL3 MAML1 KDM2B PCID2	1.55e-05	199	138	7	36688959
Pubmed	Fine tuning of the threshold of T cell selection by the Nck adapters.	NCK1 NCK2	1.56e-05	2	138	2	21078909
Pubmed	Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.	SCN1A SCN2A	1.56e-05	2	138	2	10827969
Pubmed	Shear-induced von Willebrand factor-mediated platelet surface translocation of the CD40 ligand.	VWF CD40LG	1.56e-05	2	138	2	12676191
Pubmed	Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.	SCN1A SCN2A	1.56e-05	2	138	2	19694741
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	1.56e-05	2	138	2	11448776
Pubmed	The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer.	CYP4Z1 CYP4Z2P	1.56e-05	2	138	2	28236635
Pubmed	Complete cDNA sequences of mouse rod photoreceptor cGMP phosphodiesterase alpha- and beta-subunits, and identification of beta'-, a putative beta-subunit isozyme produced by alternative splicing of the beta-subunit gene.	PDE6A PDE6B	1.56e-05	2	138	2	1847109
Pubmed	Differential expression of two sodium channel subtypes in human brain.	SCN1A SCN2A	1.56e-05	2	138	2	1317301
Pubmed	Correlation between LRIG1 and LRIG2 expressions and expression of 11 tumor markers, with special reference to tumor suppressors, in CIN and normal cervical epithelium.	LRIG2 LRIG1	1.56e-05	2	138	2	21632100
Pubmed	cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas.	DVL1 DVL3	1.56e-05	2	138	2	9344861
Pubmed	Nck adaptor proteins control the organization of neuronal circuits important for walking.	NCK1 NCK2	1.56e-05	2	138	2	18093944
Pubmed	Scn2a deletion improves survival and brain-heart dynamics in the Kcna1-null mouse model of sudden unexpected death in epilepsy (SUDEP).	KCNA1 SCN2A	1.56e-05	2	138	2	28334922
Pubmed	Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation.	NCK1 NCK2	1.56e-05	2	138	2	19596797
Pubmed	Structural disease progression in PDE6-associated autosomal recessive retinitis pigmentosa.	PDE6A PDE6B	1.56e-05	2	138	2	30153077
Pubmed	Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.	SCN1A SCN2A	1.56e-05	2	138	2	31439038
Pubmed	Allowing for sex differences increases power in a GWAS of multiplex Autism families.	RYR2 UPP2	1.56e-05	2	138	2	21151189
Pubmed	Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.	CYP4Z1 CYP4Z2P	1.56e-05	2	138	2	15059886
Pubmed	Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models.	KCNA1 SCN1A	1.56e-05	2	138	2	25855492
Pubmed	Phosphodiesterase inhibitors block the acceleration of skin permeability barrier repair by red light.	PDE6A PDE6B	1.56e-05	2	138	2	21410772
Pubmed	Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.	SCN1A SCN2A	1.56e-05	2	138	2	15249644
Pubmed	Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire.	NCK1 NCK2	1.56e-05	2	138	2	20709959
Pubmed	Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression.	LRIG2 LRIG1	1.56e-05	2	138	2	22484910
Pubmed	Endothelial NCK2 promotes atherosclerosis progression in male but not female Nck1-null atheroprone mice.	NCK1 NCK2	1.56e-05	2	138	2	36035930
Pubmed	Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development.	NCK1 NCK2	1.56e-05	2	138	2	37479911
Pubmed	The cGMP phosphodiesterase-transducin complex of retinal rods. Membrane binding and subunits interactions.	PDE6A PDE6B	1.56e-05	2	138	2	1326553
Pubmed	Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.	DVL1P1 DVL1	1.56e-05	2	138	2	8644734
Pubmed	SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.	SCN1A SCN2A	1.56e-05	2	138	2	30693367
Pubmed	Novel variants in PDE6A and PDE6B genes and its phenotypes in patients with retinitis pigmentosa in Chinese families.	PDE6A PDE6B	1.56e-05	2	138	2	35033039
Pubmed	Expression of dishevelled gene in Hirschsprung's disease.	DVL1 DVL3	1.56e-05	2	138	2	24040443
Pubmed	Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.	SCN1A SCN2A	1.56e-05	2	138	2	29649454
Pubmed	Cone phosphodiesterase-6α' restores rod function and confers distinct physiological properties in the rod phosphodiesterase-6β-deficient rd10 mouse.	PDE6A PDE6B	1.56e-05	2	138	2	23864662
Pubmed	Non-compensating roles between Nckalpha and Nckbeta in PDGF-BB signaling to promote human dermal fibroblast migration.	NCK1 NCK2	1.56e-05	2	138	2	19242519
Pubmed	High-resolution molecular genomic autopsy reveals complex sudden unexpected death in epilepsy risk profile.	KCNA1 SCN1A	1.56e-05	2	138	2	24372310
Pubmed	The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1.	CYP4Z1 CYP4Z2P	1.56e-05	2	138	2	25701119
Pubmed	Rod phosphodiesterase-6 PDE6A and PDE6B subunits are enzymatically equivalent.	PDE6A PDE6B	1.56e-05	2	138	2	20940301
Pubmed	Mechanism and functional impact of CD40 ligand-induced von Willebrand factor release from endothelial cells.	VWF CD40LG	1.56e-05	2	138	2	25608503
Pubmed	[A uNick protein].	NCK1 NCK2	1.56e-05	2	138	2	21880263
Pubmed	Nck adaptor proteins modulate differentiation and effector function of T cells.	NCK1 NCK2	1.56e-05	2	138	2	25995205
Pubmed	Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.	SCN1A SCN2A	1.56e-05	2	138	2	33096315
Pubmed	Nck influences preosteoblastic/osteoblastic migration and bone mass.	NCK1 NCK2	1.56e-05	2	138	2	26621720
Pubmed	DVL1 and DVL3 require nuclear localisation to regulate proliferation in human myoblasts.	DVL1 DVL3	1.56e-05	2	138	2	35589804
Pubmed	Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.	SCN1A SCN2A	1.56e-05	2	138	2	26311622
Pubmed	Beta-subunit of bovine rod photoreceptor cGMP phosphodiesterase. Comparison with the phosphodiesterase family.	PDE6A PDE6B	1.56e-05	2	138	2	2165490
Pubmed	Kv1.1 deficiency alters repetitive and social behaviors in mice and rescues autistic-like behaviors due to Scn2a haploinsufficiency.	KCNA1 SCN2A	1.56e-05	2	138	2	33484493
Pubmed	Photoreceptor Phosphodiesterase (PDE6): Structure, Regulatory Mechanisms, and Implications for Treatment of Retinal Diseases.	PDE6A PDE6B	1.56e-05	2	138	2	34170501
Pubmed	The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.	SCN1A SCN2A	1.56e-05	2	138	2	21377452
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	1.56e-05	2	138	2	16041389
Pubmed	Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins.	TANC2 TANC1	1.56e-05	2	138	2	21068316
Pubmed	The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains.	NCK1 NCK2	1.56e-05	2	138	2	16636066
Pubmed	DVL3 Alleles Resulting in a -1 Frameshift of the Last Exon Mediate Autosomal-Dominant Robinow Syndrome.	DVL1 DVL3	1.56e-05	2	138	2	26924530
Pubmed	Longitudinal Clinical Follow-up and Genetic Spectrum of Patients With Rod-Cone Dystrophy Associated With Mutations in PDE6A and PDE6B.	PDE6A PDE6B	1.56e-05	2	138	2	30998820
Pubmed	Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.	TIAM1 SPON1 MX1	1.70e-05	13	138	3	8812055
Pubmed	Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.	PDE6A PDE1B PDE6B	1.70e-05	13	138	3	8557689
Pubmed	Nonsyndromic Retinitis Pigmentosa Overview	SPATA7 ARL2BP PDE6A PDE6B BBS2	1.84e-05	81	138	5	20301590
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	CDC42EP4 BCCIP ARPC2 MDN1 LRIG1 G3BP2 DYNC1LI1 COG4	2.10e-05	288	138	8	23383273
Pubmed	MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation.	TANC2 POLR2H NCK1 G3BP2 HADHA FKBP5 NCK2	2.63e-05	216	138	7	32640226
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	VPS37C DLG5 FAM120B POLR2H CHD9 UFL1 CHD2 CHD7 NSRP1 HNRNPF DYNC1LI1 ALB HADHA COG4 RPL10	2.77e-05	1082	138	15	38697112
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	DLG5 SUPT3H POLR2H MAML1 UFL1 CHD2 CHD7 API5 POLR1F MDN1 KDM2B TANC1 MTREX ANAPC5 USP6NL PCID2 RPL10 CDK7	2.79e-05	1497	138	18	31527615
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TANC2 ZNF473 ARHGEF18 GPAM PPP4R3A FAN1 LRIG2 NEK1 SPON1 DNAH17	2.93e-05	493	138	10	15368895
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	PDE6A CHD7 API5 CC2D2B IBTK AKAP9 KDM2B DYNC1LI1 HADHA	3.09e-05	396	138	9	26687479
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	FLII ERCC6L MAML1 CHD7 KDM2B YY1AP1 ALB HADHA SMCR8	3.22e-05	398	138	9	35016035
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	CUL4B DLG5 MYO1D CEP162 MAML1 BCCIP ARPC2 ARHGAP5 IBTK KIAA1217 DYNC1LI1 TANC1 PCID2	3.75e-05	853	138	13	28718761
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	GPAM CHD2 CHN1 TMEM132B HNRNPF ARHGAP5 MDN1 EDAR PRKCB ALB HADHA RPL10	3.96e-05	736	138	12	29676528
Pubmed	Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.	FLII MYO1D CALU CHD7 HNRNPF ARPC2 KIAA1217 G3BP2 CHMP3 HADHA RPL10	4.31e-05	626	138	11	33644029
Pubmed	Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation.	NCK1 NCK2	4.68e-05	3	138	2	14676213
Pubmed	Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.	SCN1A SCN2A	4.68e-05	3	138	2	32185219
Pubmed	Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort.	SCN1A SCN2A	4.68e-05	3	138	2	32005694
Pubmed	Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.	DVL1 DVL3	4.68e-05	3	138	2	18093802
Pubmed	Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling.	NCK1 NCK2	4.68e-05	3	138	2	33917227
Pubmed	DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway.	DVL1 DVL3	4.68e-05	3	138	2	32900645
Pubmed	Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation.	TANC2 TANC1	4.68e-05	3	138	2	38092135
Pubmed	Nck adaptors, besides promoting N-WASP mediated actin-nucleation activity at pedestals, influence the cellular levels of enteropathogenic Escherichia coli Tir effector.	NCK1 NCK2	4.68e-05	3	138	2	25482634
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN2A	4.68e-05	3	138	2	23859570
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	4.68e-05	3	138	2	25637021
Pubmed	Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.	DVL1 DVL3	4.68e-05	3	138	2	27744318
Pubmed	New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene.	PDE6A PDE6B	4.68e-05	3	138	2	18849587
Pubmed	A Study of Interleukin-2 Production and Nck Adaptor Molecule Gene Expression in Systemic Lupus Erythematosus Patients.	NCK1 NCK2	4.68e-05	3	138	2	29911835
Pubmed	Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS.	DVL1 DVL3	4.68e-05	3	138	2	26359454
Interaction	NR3C1 interactions	TANC2 PDE6A MYO1D ERCC6L CALU VPS33A MAML1 FAM161B CHD9 CHD2 CHD7 RYR2 MDN1 GUCY1B2 PPT1 G3BP2 KDM2B HADHA SMCR8 FKBP5	7.68e-06	974	135	20	int:NR3C1
Interaction	SORBS3 interactions	VPS37C DLG5 DVL3 NCK1 HNRNPF KIAA1217 ALB COG4 CDK7	8.99e-06	202	135	9	int:SORBS3
Cytoband	12q24.31	PITPNM2 COQ5 VPS33A TMEM132B KDM2B ANAPC5	1.66e-07	80	138	6	12q24.31
GeneFamily	PDZ domain containing	DLG5 DVL1 DVL3 MAGI2 TIAM1 RHPN2	1.11e-04	152	90	6	1220
GeneFamily	Dishevelled segment polarity proteins\|PDZ domain containing	DVL1 DVL3	1.46e-04	4	90	2	505
GeneFamily	Phosphodiesterases	PDE6A PDE1B PDE6B	2.24e-04	24	90	3	681
GeneFamily	ESCRT-I	VPS37C VPS37A	8.62e-04	9	90	2	1116
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN2A	8.62e-04	9	90	2	1203
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	1.07e-03	10	90	2	830
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TANC2 TTC16 TANC1 FKBP5	2.61e-03	115	90	4	769
GeneFamily	Dyneins, axonemal	DNAH17 DNAH8	3.17e-03	17	90	2	536
GeneFamily	DNA helicases	CHD2 CHD7	3.17e-03	17	90	2	1167
Coexpression	WIERENGA_PML_INTERACTOME	CALU HNRNPF DUOX1 PRKCB ALB	2.64e-06	42	137	5	M2219
ToppCell	Mild-Myeloid-Mast\|Mild / Condition, Lineage, Cell class and cell subclass	PITPNM2 PDE6A VWF RAB44 FAM83F TANC1 RPL10	8.50e-07	165	138	7	5fa9552c37890c5cc7e672a47038aebba2413cb4
ToppCell	Mild-Myeloid-Mast-\|Mild / Condition, Lineage, Cell class and cell subclass	PITPNM2 PDE6A VWF RAB44 FAM83F TANC1 RPL10	8.50e-07	165	138	7	93d3909a0f5f43d473d5005c842d7d73e25eceed
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CHN1 EDAR TIAM1 SPON1 PRKCB UNC13C TANC1	2.50e-06	194	138	7	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DLG5 ERCC6L GPAM CHD2 TIAM1 RASA4 MMRN2	2.59e-06	195	138	7	6a0460d949ccda7c9fe76870d3ee6c2f60677d61
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CHN1 MAGI2 EDAR TIAM1 SPON1 PRKCB UNC13C	2.59e-06	195	138	7	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	Control-Lymphoid-T\|Lymphoid / Disease state, Lineage and Cell class	SUPT3H RYR2 LRIG1 CD40LG TIFA FKBP5 NCK2	2.59e-06	195	138	7	6687e579582d7a239bee80846de0cf827a6f6a62
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-Trm_Th1/Th17\|Liver / Manually curated celltypes from each tissue	ANO9 ZC3H12A CHN1 LRIG1 CD40LG FKBP5 NCK2	2.59e-06	195	138	7	480cc62ee1e5b1aaf6b62be6e5afd7a81236a1b0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	LSM5 LINS1 TIAM1 G3BP2 CD40LG FKBP5 NCK2	2.77e-06	197	138	7	479841809554a9d0b1e4f23da6e657392b0f4971
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DLG5 MYO1D ARHGAP5 DUOX1 AKAP9 LRIG1 KIAA1217	3.06e-06	200	138	7	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	PBMC-Control-cDC_8\|Control / Compartment, Disease Groups and Clusters	VPS37C ZC3H12A TTC16 CAGE1 RAB44 SMCR8	8.32e-06	153	138	6	db1a6914f2033fb0748e0523cffe5d6dc4e901be
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8\|TCGA-Liver / Sample_Type by Project: Shred V9	PITPNM2 TDRD15 VWF MMRN2 EDEM1 UPP2	1.57e-05	171	138	6	c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TANC2 DLG5 CHD2 FAM83F KIAA1217 TANC1	2.03e-05	179	138	6	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-CD45____B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DVL3 ARHGEF18 RYR2 MCM9 PRKCB MX1	2.03e-05	179	138	6	69c74b2ff43b43653005807654953daf21f932ec
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSNAXIP1 VWF TTC16 PLXNC1 SPON1 MMRN2	2.75e-05	189	138	6	1137583e21d874c201c20581ba1995e2bfa3de59
ToppCell	facs-Skin-Anagen-3m-Epithelial\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CALU DVL3 HNRNPF ALB ANAPC5 NCK2	2.84e-05	190	138	6	888ded899f0513d41bf655896d59ae8ef74e0978
ToppCell	facs-Skin-Anagen-3m\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CALU DVL3 HNRNPF ALB ANAPC5 NCK2	2.84e-05	190	138	6	3466cebab16964e94da130d0673fa32e7d90b5ed
ToppCell	ILEUM-non-inflamed-(1)_T_cell-(1)_TFH-like\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	EDAR TIAM1 CD40LG DNAH8 FKBP5 RPL10	3.01e-05	192	138	6	0f9cae41bb9bc9366efe9eb48e26b3e80c642879
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARHGAP5 LINS1 LRIG1 TIAM1 CD40LG NCK2	3.01e-05	192	138	6	7ab626a516b07d899175ff12f1c8257688324e4b
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARHGAP5 LINS1 LRIG1 TIAM1 CD40LG NCK2	3.10e-05	193	138	6	194b49c152e3e3f599068ec88a7f0af6427b743a
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RYR2 MAGI2 COLEC12 SPON1 PRKCB UNC13C	3.19e-05	194	138	6	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RYR2 MAGI2 COLEC12 SPON1 PRKCB UNC13C	3.19e-05	194	138	6	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	MYO1D SNTN CYP4Z2P LRIG1 KIAA1217 TANC1	3.28e-05	195	138	6	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	MYO1D SNTN CYP4Z2P LRIG1 KIAA1217 TANC1	3.28e-05	195	138	6	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	COVID-19_Convalescent-CD4+_Tcm\|COVID-19_Convalescent / Disease condition and Cell class	SUPT3H CHN1 TIAM1 CD40LG RPL10 NCK2	3.38e-05	196	138	6	f2a5eeb1cebde2762865ab29792370b751214c4d
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	GDF10 NAALADL2 COLEC12 TIAM1 PRKCB UNC13C	3.38e-05	196	138	6	1450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell	IPF-Lymphoid-T\|Lymphoid / Disease state, Lineage and Cell class	RYR2 LRIG1 TIAM1 CD40LG FKBP5 NCK2	3.38e-05	196	138	6	6e70c48a63d9673eb16b0847c1bd88eecc2f7a3c
ToppCell	LPS_IL1RA_TNF\|World / Treatment groups by lineage, cell group, cell type	CHD9 COLEC12 AKAP9 SPON1 DYNC1LI1 MX1	3.47e-05	197	138	6	0a6550dce156fc81f15b1e7830d331ca50d87d06
ToppCell	COPD-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	PITPNM2 VWF CDC42EP4 CYP4Z2P KIAA1217 FKBP5	3.47e-05	197	138	6	30dbc05ea66892d2e18ff375ffa86d1db7bc4083
ToppCell	10x5'-Liver-Lymphocytic_T_CD4\|Liver / Manually curated celltypes from each tissue	ANO9 CHN1 LRIG1 CD40LG FKBP5 NCK2	3.47e-05	197	138	6	4891111894b741555f549deec6af8006376d9358
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TANC2 ACADL GPAM COLEC12 DUOX1 SCN1A	3.57e-05	198	138	6	f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6\|World / Primary Cells by Cluster	RYR2 MAGI2 AKAP9 SCN2A UNC13C RPL10	3.67e-05	199	138	6	1b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCell	Sigmoid-T_cell-Th17\|T_cell / Region, Cell class and subclass	CHD7 CHN1 CD40LG TIFA FKBP5 RPL10	3.67e-05	199	138	6	622f2ae4b1850b25f723a0385da49147dfec8285
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal\|World / Primary Cells by Cluster	RYR2 MAGI2 AKAP9 SCN2A UNC13C RPL10	3.67e-05	199	138	6	4bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Myeloid-Megakaryocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF18 KRBA2 GPAM RAB44 RASA4B TANC1	3.67e-05	199	138	6	6e7f7214317f2af2ba8523df9896f54b7294d58a
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Myeloid\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF18 KRBA2 GPAM RAB44 RASA4B TANC1	3.67e-05	199	138	6	5f499595597c10857bba8272f62afe4d32d733ac
ToppCell	Sepsis-URO-Lymphocyte-T/NK-CD4+_Tem\|URO / Disease, condition lineage and cell class	SUPT3H CHN1 SCN2A CD40LG RPL10 NCK2	3.78e-05	200	138	6	8b7bfe6411de9528603481f6e5612cbbb8471cf6
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CYP4Z1 BBS2 GPAM GDF10 SPON1 ALB	3.78e-05	200	138	6	7a8160e6477708f22e48c609bf8f43f3715dcb03
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BBS2 GPAM GDF10 LRIG1 SPON1 PYGM	3.78e-05	200	138	6	d0812817ef99608994193787a62d39adeb2070ca
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DLG5 MYO1D ARHGAP5 DUOX1 AKAP9 KIAA1217	3.78e-05	200	138	6	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BBS2 GPAM GDF10 LRIG1 SPON1 PYGM	3.78e-05	200	138	6	cd54ddf1919c98e84b7e4aba85b374fc8b407206
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_stem_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	FAN1 CTCFL DUOX1 MDN1 SCN1A	6.82e-05	137	138	5	ed81624b9167255ce88dcf6ad7f1636376ea0525
ToppCell	COVID-19_Convalescent-PLT_3\|World / Disease Group and Platelet Clusters	FAM161B DNAAF9 IBTK PYGM USP6NL	6.82e-05	137	138	5	bb54bb81b450462ad521b57e1a07a80ce1678e67
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_stem_cell-Mesenchymal_fibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	FAN1 CTCFL DUOX1 MDN1 SCN1A	6.82e-05	137	138	5	47859aa25f32367461c1ec75ed9060bee430c6b7
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FAM120B PLXNC1 SENP6 PRKCB MX1	1.26e-04	156	138	5	f5889a6899904dfb7f596600b3a76857cf9d5378
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-Trm_Th1/Th17\|bone_marrow / Manually curated celltypes from each tissue	ZC3H12A CHN1 KIAA1217 CD40LG NCK2	1.54e-04	163	138	5	4d1fd0b1246833723b938eca0cb246e937380e12
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-Tfh\|bone_marrow / Manually curated celltypes from each tissue	SPON1 CD40LG TIFA FKBP5 NCK2	1.68e-04	166	138	5	9ac5267d3a53a96dec9eae3bc01acba4750742c8
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM161B ARHGEF18 CD40LG PRKCB DNAH8	1.73e-04	167	138	5	754e6412d3b9cc0b126e59593df2f5956b4712ef
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VWF CC2D2B RASA4 MMRN2 RASA4B	1.88e-04	170	138	5	1a568efcff9c39b3f709b55a05d24710450a2657
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VWF CC2D2B RASA4 MMRN2 RASA4B	1.88e-04	170	138	5	66d41d794790e621d72ac37af995510537103c9c
ToppCell	PND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VPS37C PDE6A PDE1B TIFA MMRN2	2.04e-04	173	138	5	03b50b2376d353748a32bf14a9fc8341ea61dbca
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP162 CHN1 RYR2 TIFA NCK2	2.04e-04	173	138	5	3059325901b1e5e12a1a91183f14267288b2f600
ToppCell	PND28-Endothelial-Endothelial_lymphatic\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VPS37C PDE6A PDE1B TIFA MMRN2	2.04e-04	173	138	5	2978c744d3c8dcaa2b9bb225abf846f82e8f9176
ToppCell	PND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VPS37C PDE6A PDE1B TIFA MMRN2	2.04e-04	173	138	5	12da47b90aecedaa31764ff7ddb853ee39123e9d
ToppCell	PND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VPS37C PDE6A PDE1B TIFA MMRN2	2.04e-04	173	138	5	23d4a315a0ad5c6fc77bcfc18b6c1ff55be99e8f
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP162 CHN1 RYR2 TIFA NCK2	2.04e-04	173	138	5	36c8338463ee4cc432f568728d55989360f9a68d
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHD9 RYR2 ARHGAP5 IBTK HADHA	2.20e-04	176	138	5	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	droplet-Limb_Muscle-nan-24m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC1B KCNA1 PLXNC1 DNAH17 PCID2	2.32e-04	178	138	5	f2002a5c4758d0af6c1880ca12f0af0d5e8888e4
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RYR2 MAGI2 COLEC12 TIAM1 SPON1	2.45e-04	180	138	5	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PYROXD1 RAB44 LRIG1 USP6NL MX1	2.45e-04	180	138	5	be10fe5bf7c3a671c42704ce7dd8226ab6896794
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PYROXD1 RAB44 LRIG1 USP6NL MX1	2.45e-04	180	138	5	3b747a517ce75ef2ff09011c037dad7b01ed3e03
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	VPS37C FAM120B CHN1 TIAM1 RASA4	2.51e-04	181	138	5	9275531e896e118cee043ed94fd31a0070d9581c
ToppCell	facs-Spleen-nan-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHN1 ARHGAP5 LRIG1 TIAM1 CD40LG	2.57e-04	182	138	5	fbe5bdd642b86010dbef0a567b25c69c7335688f
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CHN1 LRIG1 TIAM1 CD40LG NCK2	2.57e-04	182	138	5	9ba85f621a846531a2a7861e9df695d288c9e149
ToppCell	facs-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 VWF CALU MMRN2 SLC12A7	2.64e-04	183	138	5	12e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 CPS1 RYR2 SCN2A UNC13C	2.71e-04	184	138	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 CPS1 RYR2 SCN2A UNC13C	2.71e-04	184	138	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 CPS1 RYR2 SCN2A UNC13C	2.71e-04	184	138	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	P28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TANC2 VWF G3BP2 MMRN2 SLC12A7	2.71e-04	184	138	5	8ed22b1af04a711203293e7a8b3df6fb9222fad5
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CHN1 LINS1 CD40LG RPL10 MX1	2.77e-04	185	138	5	406b52516b26e9fe2c9e768950af447ec7ad5f3e
ToppCell	Control-Lymphocyte-T_NK-CD4_TEM\|Control / Disease, Lineage and Cell Type	SUPT3H CHN1 CD40LG RPL10 NCK2	2.77e-04	185	138	5	8d6a089dcb4bfb0e74b6316fb7221688c1835e6e
ToppCell	Brain_organoid-organoid_Kanton_Nature\|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.	CHD9 CHD7 PPP4R3A AKAP9 FDPS	2.77e-04	185	138	5	857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CHN1 LINS1 CD40LG RPL10 MX1	2.77e-04	185	138	5	f2ebd099c8dfcfaca4298bcdd618c50701a9c2c8
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TANC2 VWF MYO1D RHPN2 MMRN2	2.84e-04	186	138	5	ffbc78058be8f0dc2e0335cc4c3195a636d17721
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TANC2 VWF MYO1D RHPN2 MMRN2	2.84e-04	186	138	5	ed924852cd7132c8f6703522037dc22bd2c83193
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CDC42EP4 COLEC12 LRIG1 SPON1 PYGM	2.91e-04	187	138	5	dd1d91f101b837bba513f77defa6e6902b2c0570
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CDC42EP4 COLEC12 LRIG1 SPON1 PYGM	2.91e-04	187	138	5	4d2115a05ec36dd179ca1d4a525f2d4501aea557
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CDC42EP4 COLEC12 LRIG1 SPON1 PYGM	2.91e-04	187	138	5	ae90c263f80c36a410150d499e268d198944a3d9
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLII MAML1 CHD9 TIAM1 SLC12A7	2.91e-04	187	138	5	3699d5e71d779da922920aa3160895db187bf81b
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLII MAML1 CHD9 TIAM1 SLC12A7	2.91e-04	187	138	5	033ba52c0c2f9978784947098fa697368ae44834
ToppCell	facs-Heart-RA-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF LRIG1 PLXNC1 MMRN2 SLC12A7	2.99e-04	188	138	5	4ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCell	facs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF LRIG1 PLXNC1 MMRN2 SLC12A7	2.99e-04	188	138	5	e47e66906922d5c69b1aafe28face0787d3fc563
ToppCell	severe_influenza-CD4+_Tcm\|severe_influenza / disease group, cell group and cell class (v2)	ANO9 CHN1 CD40LG RPL10 NCK2	2.99e-04	188	138	5	633e5545f49b1b864b0ffa5fc9688d270690f884
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Striatum / BrainAtlas - Mouse McCarroll V32	PDE1B CHN1 AKAP9 SCN2A PRKCB	2.99e-04	188	138	5	e34ea7014c5a059a7db38f78bd903cf02616ddd3
ToppCell	facs-BAT-Fat-3m\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GDF10 HNRNPF MTREX ANAPC5 FKBP5	3.06e-04	189	138	5	7ce71f9c81512ed38c804f025908746b4af3aab1
ToppCell	facs-Skin-Anagen\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DVL3 GDF10 HNRNPF ALB NCK2	3.06e-04	189	138	5	adbfc723130079b4caf551f66d2aee86fab1903c
ToppCell	10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like\|bone_marrow / Manually curated celltypes from each tissue	SUPT3H ZC3H12A SPON1 G3BP2 CD40LG	3.06e-04	189	138	5	ac2995e599f3d1813218479dc515b1d612c0ef8b
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GDF10 RYR2 COLEC12 SPON1 DYNC1LI1	3.06e-04	189	138	5	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CDC42EP4 COLEC12 LRIG1 SPON1 PYGM	3.14e-04	190	138	5	5c64b727669b23d2a23c8ad1d5d6caab7af37d56
ToppCell	Control-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	PITPNM2 VWF CDC42EP4 KIAA1217 FKBP5	3.14e-04	190	138	5	7f3f419fffe02934b6f27b697f7a6401072491ed
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSNAXIP1 VWF TTC16 SPON1 MMRN2	3.14e-04	190	138	5	7068754c29f63a331e2b6c54715f3b26f37ad32b
ToppCell	MS-CD8-antiviral_CD4\|MS / Condition, Cell_class and T cell subcluster	TTC16 COLEC12 LRIG1 RIOK2 MX1	3.14e-04	190	138	5	8c831c4560b8e70f92b4c15644fea39f7f7afcf2
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TANC2 VWF MYO1D RHPN2 MMRN2	3.14e-04	190	138	5	3b9abc25b17e7295356ded57ff2ca519fa9f2686
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF PLXNC1 SPON1 MMRN2 SLC12A7	3.14e-04	190	138	5	6f71a9f74af7cd9a674753cfc9833ebe5bba0fa2
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	GDF10 NAALADL2 TIAM1 SPON1 UNC13C	3.14e-04	190	138	5	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CDC42EP4 COLEC12 LRIG1 SPON1 PYGM	3.14e-04	190	138	5	b56c55f608b30f7379941ac7d5f0f5200f305fca
ToppCell	T_cells-Effector_memory_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	MYO1D LRIG1 CD40LG FKBP5 NCK2	3.14e-04	190	138	5	1af91fe0ee2c924e12f4db93c793e7af475d8f80
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ACADL NAALADL2 FAM83F SCN2A UNC13C	3.21e-04	191	138	5	3e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF KIAA1217 TIFA TANC1 FKBP5	3.21e-04	191	138	5	a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCell	10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like-MAIT\|bone_marrow / Manually curated celltypes from each tissue	SUPT3H ZC3H12A SPON1 G3BP2 CD40LG	3.21e-04	191	138	5	7a28905ad504979497836e87df81d529e675ce78
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF PLXNC1 SPON1 MMRN2 SLC12A7	3.29e-04	192	138	5	0b9b2eaed45456d7d74ce78a64ef4a26ac2458fb
Disease	CHARGE syndrome (implicated_via_orthology)	CHD9 CHD2 CHD7	3.23e-06	7	135	3	DOID:0050834 (implicated_via_orthology)
Disease	Retinitis Pigmentosa	SPATA7 ARL2BP PDE6A PDE6B BBS2 ARHGEF18	8.62e-06	104	135	6	C0035334
Disease	Early infantile epileptic encephalopathy with suppression bursts	KCNA1 SCN1A SCN2A	5.02e-05	16	135	3	C0393706
Disease	epilepsy (implicated_via_orthology)	KCNA1 KCNA10 SCN1A SCN2A UNC13C SLC12A7	1.08e-04	163	135	6	DOID:1826 (implicated_via_orthology)
Disease	Robinow Syndrome	DVL1 DVL3	1.24e-04	4	135	2	C0265205
Disease	Robinow Syndrome, Autosomal Dominant	DVL1 DVL3	1.24e-04	4	135	2	C4551476
Disease	Epilepsy	TANC2 CHD2 SCN1A SCN2A ALB	1.48e-04	109	135	5	C0014544
Disease	DiGeorge syndrome (is_implicated_in)	DVL1P1 DVL1	2.06e-04	5	135	2	DOID:11198 (is_implicated_in)
Disease	Nephrotic Syndrome	NCK1 ALB NCK2	2.53e-04	27	135	3	C0027726
Disease	Lennox-Gastaut syndrome	CHD2 SCN1A	3.08e-04	6	135	2	C0238111
Disease	Myopathy	PYROXD1 PYGM ALB	3.47e-04	30	135	3	C0026848
Disease	Seizure, Febrile, Simple	SCN1A SCN2A	4.30e-04	7	135	2	C0149886
Disease	Seizure, Febrile, Complex	SCN1A SCN2A	4.30e-04	7	135	2	C0751057
Disease	10-undecenoate 11:1n1 measurement	CYP4Z1 CYP4Z2P	4.30e-04	7	135	2	EFO_0021099
Disease	nicotine dependence	DVL1P1 DVL1 POLR1F TANC1	4.60e-04	78	135	4	EFO_0003768
Disease	Epilepsy, Cryptogenic	CHD2 SCN1A SCN2A ALB	5.56e-04	82	135	4	C0086237
Disease	Awakening Epilepsy	CHD2 SCN1A SCN2A ALB	5.56e-04	82	135	4	C0751111
Disease	Aura	CHD2 SCN1A SCN2A ALB	5.56e-04	82	135	4	C0236018
Disease	Autism Spectrum Disorders	CHD2 RYR2 SCN1A UPP2	6.37e-04	85	135	4	C1510586
Disease	autism spectrum disorder (implicated_via_orthology)	CHD9 CHD2 CHD7 SCN1A SCN2A	6.88e-04	152	135	5	DOID:0060041 (implicated_via_orthology)
Disease	Febrile Convulsions	SCN1A SCN2A	7.32e-04	9	135	2	C0009952
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN2A	7.32e-04	9	135	2	C3502809
Disease	Neurodevelopmental Disorders	TANC2 CHD2 SCN1A SCN2A	8.93e-04	93	135	4	C1535926
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN2A	9.13e-04	10	135	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN2A	9.13e-04	10	135	2	DOID:0080422 (implicated_via_orthology)
Disease	Proteinuria	NCK1 ALB NCK2	1.01e-03	43	135	3	C0033687
Disease	serum gamma-glutamyl transferase measurement	DLG5 CHD9 NCK1 CPS1 RYR2 EDAR RHPN2 KDM2B YY1AP1 ANAPC5 USP6NL FKBP5	1.03e-03	914	135	12	EFO_0004532
Disease	Cognitive impairment	NAALADL2 RYR2	1.11e-03	11	135	2	HP_0100543
Disease	Myoclonic Astatic Epilepsy	CHD2 SCN1A	1.11e-03	11	135	2	C0393702
Disease	end stage renal disease (is_marker_for)	VWF CD40LG ALB	1.23e-03	46	135	3	DOID:783 (is_marker_for)
Disease	homocysteine measurement	CPS1 POLR1F COLEC12	1.23e-03	46	135	3	EFO_0004578
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN2A	1.33e-03	12	135	2	DOID:0060170 (implicated_via_orthology)
Disease	Neurobehavioral Manifestations	MAGI2 FKBP5	1.33e-03	12	135	2	C0525041
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN2A	1.57e-03	13	135	2	C0751122
Disease	autoimmune thrombocytopenic purpura (is_marker_for)	CD40LG ALB	1.57e-03	13	135	2	DOID:8924 (is_marker_for)
Disease	retinal drusen	VWF COLEC12 UNC13C	1.66e-03	51	135	3	EFO_1001155
Disease	Orofacial cleft	TANC2 LRIG1 RHPN2	1.66e-03	51	135	3	HP_0000202
Disease	Ciliopathies	SPATA7 BBS2 NEK1 DNAH8	1.66e-03	110	135	4	C4277690
Disease	phosphatidylcholine measurement	VPS37C TDRD15 CEP162 GPAM CHD7 ALB	2.01e-03	284	135	6	EFO_0010226
Disease	MMR-related febrile seizures	SCN1A SCN2A	2.10e-03	15	135	2	EFO_0006519
Disease	Proteinuria	VWF UNC13C	2.10e-03	15	135	2	HP_0000093
Disease	Disorder of eye	SPATA7 PDE6A PDE6B BBS2 PPT1	2.98e-03	212	135	5	C0015397
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN1A SCN2A	3.03e-03	18	135	2	HP_0002373
Disease	carotid artery disease (is_marker_for)	VWF CD40LG	3.38e-03	19	135	2	DOID:3407 (is_marker_for)
Disease	venous thromboembolism, fibrinogen measurement	VWF CHD9 CPS1	3.62e-03	67	135	3	EFO_0004286, EFO_0004623
Disease	heart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer	POLR1F MX1	3.74e-03	20	135	2	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Disease	coagulation factor measurement	VWF PCID2	3.74e-03	20	135	2	EFO_0004634
Disease	synophrys measurement	SUPT3H CEP162 EDAR	3.78e-03	68	135	3	EFO_0007906
Disease	total cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer	TDRD15 POLR1F MX1	3.94e-03	69	135	3	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Disease	susceptibility to mononucleosis measurement	RYR2 MDN1 DNAH8	3.94e-03	69	135	3	EFO_0008403
Disease	amino acid measurement	TANC2 VWF CPS1 RYR2 LRIG1 MCM9 SENP6 DYNC1LI1 UNC13C	4.08e-03	678	135	9	EFO_0005134
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN2A	4.52e-03	22	135	2	DOID:2030 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EADLQAEVKTFMFAG	CYP4Z2P	301	Q8N1L4
VFDEDKTFVAETLEM	AKAP9	916	Q99996
EDKVSFENMTVGEES	AKAP9	1051	Q99996
ITGEMDEADSAFLKF	ARHGEF18	371	Q6ZSZ5
KAGIIEEMLEDTFES	CHMP3	136	Q9Y3E7
EQLKAVMDDFAAFVE	ALB	566	P02768
EAFDDEMTEKPEFQS	CAGE1	131	Q8TC20
TKEQLFFVETMSGDE	CTCFL	196	Q8NI51
FEGFVKDIMLNKEET	CD40LG	91	P29965
MGLKAQDTAELFFED	ACADL	251	P28330
IQEVLFDMTDAGIDF	ADH6	251	P28332
FEVGDSMASEEVKQE	COG4	381	Q9H9E3
DDDDVVIGKVFMQEF	ARPC2	171	O15144
TMEDIDKNADGFIDL	CALU	196	O43852
KVLEDVTGEEFVLFM	API5	181	Q9BZZ5
FVNLMFEDQDKAEEI	ADCY10	296	Q96PN6
KDEVAGDIFDMLLTF	ARL2BP	101	Q9Y2Y0
ETFEDLMKDGVFEAR	ANO9	136	A1A5B4
FKSMDDDFGVVKEEI	DVL3	46	Q92997
NVAESEEEEFMKEFI	CC2D2B	131	Q6DHV5
TFMQEFGDLKTEEQV	CHD7	1161	Q9P2D1
NETFEFELQEGAMEA	RASA4	181	O43374
EMEKGEFDDKEAFVT	NSRP1	131	Q9H0G5
NETFEFELQEGAMEA	RASA4B	181	C9J798
EADAEEKEAFLAFME	RAB44	141	Q7Z6P3
VGMLQEDEKFLTDLF	PPP4R3A	301	Q6IN85
AEGELKDMEQFFDDL	ANAPC5	101	Q9UJX4
ESMFRESGFQDKEEL	DUOX1	901	Q9NRD9
MDEVKFFSQEKDLDG	FAM47C	906	Q5HY64
QLLMNEFESAKGDFE	FKBP5	361	Q13451
SVPDEDMKDLFNEDF	MAML1	261	Q92585
VQAMKEDGFFLLDEI	MDN1	1456	Q9NU22
LDEGFVEDFSEQMEI	MDN1	4496	Q9NU22
EEMGDESEEFLQVFD	FLII	581	Q13045
AMEKFREDEGFIKEE	KCNA1	126	Q09470
VFIEQDDDMLEAAKA	LINS1	441	Q8NG48
IFITVEDFMELEKSG	MAGI2	156	Q86UL8
MPDDDVFFITDVKID	LRIG1	651	Q96JA1
LHLEQEMGFEKFFEV	NEK1	1191	Q96PY6
DEELNFEKGDVMDVI	NCK1	206	P16333
EEELNFEKGETMEVI	NCK2	211	O43639
FFEEFGKLLREADEM	IBTK	546	Q9P2D0
AALFGEEVLEEMSEQ	MMRN2	611	Q9H8L6
KILLEMGEFFQIQDD	FDPS	296	P14324
EAPDNVVMFSEKDEF	EDAR	241	Q9UNE0
DFKVLAFDLQQMIDE	TMPRSS15	81	P98073
VEDMFIFENVGFTKD	RABIF	71	P47224
NDDMDEDEVFGFISL	BCCIP	116	Q9P287
FVHEKEIMAEDDQVF	DYNC1LI1	361	Q9Y6G9
EVFMAASQVLDFDEK	GDF10	346	P55107
FAELQMDKLDVVDSF	PLXNC1	996	O60486
DDEMNIFINLTKDEF	PDE1B	306	Q01064
MGEVTAEEVEKFLDS	PDE6A	1	P16499
SADEMFKFQEGALDD	PDE6B	361	P35913
MKDDFAEEEEVQSFG	COLEC12	1	Q5KU26
EFDTDFLDFMTKING	DNAH8	421	Q96JB1
ETEDIDLKALGFDMA	DLG5	626	Q8TDM6
EEDLESFFQDKDRGM	FAM161B	101	Q96MY7
FEGEDEDELFQSIME	PRKCB	541	P05771
MELKVFDQDLVTGDD	PLA2G4B	76	P0C869
KMAQFNEDGEEATEL	PITPNM2	256	Q9BZ72
LGFDDFVNMVLEDVT	LSM5	41	Q9Y4Y9
EIGKTLMEDVENSFF	PPT1	71	P50897
MDQFREDEGFIKDPE	KCNA10	176	Q16322
DAFLVALKFMQVEDV	PCID2	341	Q5JVF3
VVFSEDEMKKFLEEA	CPS1	1141	P31327
ESTFMQEFGDLKTEE	CHD9	1051	Q3L8U1
EDTVEEEEGKFNLML	KDM2B	671	Q8NHM5
FDIRVFKEDEIVAEM	BBS2	186	Q9BXC9
IDDMVLDEFDQFIRK	DNAH17	866	Q9UFH2
FKVANFATMEDEEEL	CHD2	1021	O14647
FDFMETDLEVIIKDN	CDK7	91	P50613
DIDENELKEFFMSFG	G3BP2	341	Q9UN86
SRQPDKEFSFMDEEE	CDC42EP4	336	Q9H3Q1
EAAEEFKITSFVDMV	DNAAF9	141	Q5TEA3
EEFEQFMKELSDDSF	CEP162	11	Q5TB80
ILFGEKEDLEMFNAA	EDEM1	381	Q92611
EMFGNSSIKFELDIE	TMEM259	161	Q4ZIN3
FPSQEEFKDMIEDAG	COQ5	291	Q5HYK3
QGFEKADMVIEAVFE	HADHA	436	P40939
SMDQDFGVVKEEIFD	DVL1	51	O14640
SGFSDLIEDVKMAFD	CHN1	306	P15882
SMDQDFGVVKEEIFD	DVL1P1	51	P54792
ESFFEGKNMALFEEE	SLC12A7	61	Q9Y666
GEKEKMELFVNFCED	RYR2	4181	Q92736
FEDTLEFVGFDAKMA	CUL4B	121	Q13620
IFFFDGMVEQDKRDE	FAM120B	86	Q96EK7
FLVEFESQNKEFLME	ERCC6L	706	Q2NKX8
EILDMQSSADGEFKF	KRBA2	266	Q6ZNG9
SGIIMDEEVQKEFED	MCM9	276	Q9NXL9
DDMLLFDEQEKGIVT	FAN1	391	Q9Y2M0
EAFVELGSEDDVKMA	HNRNPF	56	P52597
LFMHKELGFEEAEED	UPP2	76	O95045
AGTFQIIDEEETQFM	SPON1	111	Q9HCB6
MEKEDGESLEFFETQ	TIFA	126	Q96CG3
FDITDLVTEFMKVEE	TMEM132B	596	Q14DG7
SDFSIQLEDFFDIMK	TDRD15	1746	B5MCY1
FNADEFEDMVAEKRL	RPL10	176	P27635
VEDFFVMKEEVLARD	GPAM	506	Q9HCL2
DEHTENKLDFEDFMI	SNTN	111	A6NMZ2
EAVAKDFFDIDVIMD	GUCY1B2	71	O75343
EEEEGDKIMAELQAF	KIAA1217	1126	Q5T5P2
DFGMAEEFASKALEL	TANC1	1351	Q9C0D5
DFGMAEEFATKALEL	TANC2	1306	Q9HCD6
FFENEAIKELMTEGE	ARHGAP5	891	Q13017
FGEDEIEMKVVSLLD	RHPN2	581	Q8IUC4
AVVMDLFTDGDIFQD	FAM83F	166	Q8NEG4
KREVGIDDMFNFETF	SCN1A	1696	P35498
LFEDFVEVDDRMVEK	SMCR8	371	Q8TEV9
SVISENMFEFLEDGK	CLEC1B	176	Q9P126
EADLQAEVKTFMFAG	CYP4Z1	301	Q86W10
MEELVEFFQETLAKD	USP6NL	316	Q92738
EEASALELQMKVDFF	ZC3H12A	41	Q5D1E8
QTGELLAMFEDDEID	SUPT3H	146	O75486
FEVIQEMFQISKEDF	UNC13C	1186	Q8NB66
EADFNRSKEFMEEVI	VWF	1511	P04275
MVEFQVEFLKTLEDG	TIAM1	1091	Q13009
FNTDEEKKMVEEVFS	MTREX	411	P42285
EENFFIFGMRVEDVD	PYGM	706	P11217
EEFDVEEQSSTMLGK	PYROXD1	61	Q8WU10
KREVGIDDMFNFETF	SCN2A	1686	Q99250
EAGKMLEDELVDFSE	SENP6	921	Q9GZR1
NDVDMLNVFDFEKAG	SPATA7	431	Q9P0W8
MAGILFEDIFDVKDI	POLR2H	1	P52434
INMGDELEFEVFRLD	POLR1F	171	Q3B726
FEMTEFNQALEEIKG	RIOK2	391	Q9BVS4
KEANELMEDLFETFQ	YY1AP1	61	Q9H869
FDGAVEDFLKVLDMV	TTC16	301	Q8NEE8
FDKLTVEQEFMSGID	VPS33A	371	Q96AX1
EAMTFKDVAVVFTEE	ZNF224	6	Q9NZL3
FMEDEEGQSEPFVQK	TSNAXIP1	541	Q2TAA8
AFVFESQEDMEVFLK	SMC5	511	Q8IY18
IEEESEAMAEKFLEG	VPS37C	111	A5D8V6
KPEISFMFQDEIEDF	UFL1	471	O94874
DNIAEDFLEGKMEID	VPS37A	346	Q8NEZ2
DFLEGKMEIDDFLSS	VPS37A	351	Q8NEZ2
EEGFSQEIIEMLSKD	ZNF473	91	Q8WTR7
EDDVFFIANVKIEDM	LRIG2	656	O94898
GVDIPEDENEKMFFL	MX1	361	P20591
MAEQESLEFGKADFV	MYO1D	1	O94832
DMEKELEESGFDQFQ	NAALADL2	51	Q58DX5