Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionCDP phosphatase activity

ENTPD1 ENTPD5

1.04e-044842GO:0036384
GeneOntologyMolecularFunctionIDP phosphatase activity

ENTPD1 ENTPD5

1.73e-045842GO:1990003
GeneOntologyMolecularFunctioncell adhesion molecule binding

PRTG NEO1 GLDN PI4KA CNTN5 ANGPTL3 ITGAE TENM2 CDH6 CDH10

2.06e-045998410GO:0050839
GeneOntologyMolecularFunctionADP phosphatase activity

ENTPD1 ENTPD5

3.62e-047842GO:0043262
GeneOntologyMolecularFunctionUDP phosphatase activity

ENTPD1 ENTPD5

6.18e-049842GO:0045134
GeneOntologyCellularComponentplasma membrane protein complex

DPP6 BMPR1B NEO1 OLFM3 KCNJ16 OLFM1 ABCC9 OLFM2 NCSTN ITGAE CDH6 CDH10

8.63e-057858612GO:0098797
GeneOntologyCellularComponentextrinsic component of postsynaptic membrane

OLFM1 OLFM2 TENM2

9.78e-0522863GO:0098890
GeneOntologyCellularComponentAMPA glutamate receptor complex

OLFM3 OLFM1 OLFM2

2.52e-0430863GO:0032281
GeneOntologyCellularComponentextrinsic component of plasma membrane

OLFM1 OLFM2 TENM2 CDH6 CDH10

2.56e-04137865GO:0019897
GeneOntologyCellularComponentmembrane protein complex

SEL1L DPP6 BMPR1B NEO1 OLFM3 KCNJ16 VAMP7 OLFM1 ABCC9 OLFM2 NCSTN ITGAE CDH6 CDH10 DDOST NDUFV3

3.59e-0414988616GO:0098796
GeneOntologyCellularComponentextrinsic component of synaptic membrane

OLFM1 OLFM2 TENM2

4.00e-0435863GO:0099243
GeneOntologyCellularComponentazurophil granule

VAMP7 NCSTN HRNR GNS DDOST

5.22e-04160865GO:0042582
GeneOntologyCellularComponentprimary lysosome

VAMP7 NCSTN HRNR GNS DDOST

5.22e-04160865GO:0005766
GeneOntologyCellularComponentsynaptic membrane

TRPV1 NEO1 CNTN5 ENTPD1 OLFM1 OLFM2 NCSTN TENM2 CDH10

6.55e-04583869GO:0097060
GeneOntologyCellularComponentextrinsic component of postsynaptic density membrane

OLFM1 OLFM2

7.37e-0410862GO:0099147
GeneOntologyCellularComponentionotropic glutamate receptor complex

OLFM3 OLFM1 OLFM2

8.42e-0445863GO:0008328
GeneOntologyCellularComponentextrinsic component of postsynaptic specialization membrane

OLFM1 OLFM2

1.07e-0312862GO:0098892
GeneOntologyCellularComponentneurotransmitter receptor complex

OLFM3 OLFM1 OLFM2

1.15e-0350863GO:0098878
GeneOntologyCellularComponentazurophil granule membrane

VAMP7 NCSTN DDOST

1.85e-0359863GO:0035577
DomainNoelin-1

OLFM3 OLFM1 OLFM2

9.10e-083853PF12308
DomainNoelin_dom

OLFM3 OLFM1 OLFM2

9.10e-083853IPR022082
DomainOLF

GLDN OLFM3 OLFM1 OLFM2

2.77e-0713854PS51132
DomainOlfac-like_dom

GLDN OLFM3 OLFM1 OLFM2

2.77e-0713854IPR003112
DomainOLF

GLDN OLFM3 OLFM1 OLFM2

2.77e-0713854SM00284
DomainOLF

GLDN OLFM3 OLFM1 OLFM2

2.77e-0713854PF02191
DomainQuino_amine_DH_bsu

OLFM3 OLFM1 TENM2

1.32e-0422853IPR011044
DomainANK

TRPV1 ANKRD19P ANKRD28 ANKRD18A POTEJ POTEB2 POTEB

1.47e-04251857SM00248
DomainANK_REPEAT

TRPV1 ANKRD19P ANKRD28 ANKRD18A POTEJ POTEB2 POTEB

1.55e-04253857PS50088
DomainANK_REP_REGION

TRPV1 ANKRD19P ANKRD28 ANKRD18A POTEJ POTEB2 POTEB

1.59e-04254857PS50297
DomainAnkyrin_rpt

TRPV1 ANKRD19P ANKRD28 ANKRD18A POTEJ POTEB2 POTEB

1.92e-04262857IPR002110
DomainGPCR_2_latrophilin

OLFM1 OLFM2

2.03e-045852IPR003924
DomainSel1

SEL1L SEL1L2

5.63e-048852PF08238
DomainSEL1

SEL1L SEL1L2

5.63e-048852SM00671
DomainGDA1_CD39_NTPase

ENTPD1 ENTPD5

5.63e-048852IPR000407
DomainGDA1_CD39

ENTPD1 ENTPD5

5.63e-048852PF01150
DomainGDA1_CD39_NTPASE

ENTPD1 ENTPD5

5.63e-048852PS01238
DomainAnk

TRPV1 ANKRD19P ANKRD28 ANKRD18A POTEJ POTEB

6.07e-04228856PF00023
DomainTPR-like_helical_dom

SEL1L APPBP2 IFT172 SRP68 GPSM2 SEL1L2

6.80e-04233856IPR011990
DomainSel1-like

SEL1L SEL1L2

7.22e-049852IPR006597
DomainAnkyrin_rpt-contain_dom

TRPV1 ANKRD28 ANKRD18A POTEJ POTEB2 POTEB

1.06e-03254856IPR020683
DomainER_TARGET

HSP90B1 FKBP9 OLFM1

1.28e-0347853PS00014
Domain-

SEL1L APPBP2 SRP68 GPSM2 SEL1L2

2.55e-032078551.25.40.10
DomainALPHA_CA_2

PTPRG CA6

2.66e-0317852PS51144
DomainCarb_anhydrase

PTPRG CA6

2.66e-0317852PF00194
DomainCarb_anhydrase

PTPRG CA6

2.66e-0317852SM01057
Domain-

PTPRG CA6

2.66e-03178523.10.200.10
DomainCarbonic_anhydrase_a

PTPRG CA6

2.66e-0317852IPR001148
DomainAnk_2

TRPV1 ANKRD28 ANKRD18A POTEJ POTEB2

3.00e-03215855PF12796
Domain-

TRPV1 ANKRD28 ANKRD18A POTEJ POTEB2

5.49e-032488551.25.40.20
DomainCadherin_cytoplasmic-dom

CDH6 CDH10

5.74e-0325852IPR000233
DomainCadherin_C

CDH6 CDH10

5.74e-0325852PF01049
Domainfn3

PRTG NEO1 PTPRG CNTN5

6.41e-03162854PF00041
Pubmed

Olfactomedin 2: expression in the eye and interaction with other olfactomedin domain-containing proteins.

OLFM3 OLFM1 OLFM2

1.57e-08388321228389
Pubmed

A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors.

OLFM3 OLFM1 OLFM2

3.11e-07688337591201
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

SCO2 APPBP2 PI4KA SRP68 PCARE ANKRD18A HRNR AMOTL2 ITGAE CNOT1 DDOST RAI1

3.49e-07736881229676528
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

SEL1L DNAAF5 BPTF AARS1 HSP90B1 CDC123 FKBP9 OLFM1 SRP68 PSMD13 NCSTN CTSB CNOT1 GNS DDOST

8.54e-071297881533545068
Pubmed

POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.

POTEJ POTEB2 POTEB

8.69e-07888312475935
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

SEL1L DNAAF5 SCO2 AARS1 IGF2BP2 TRIM26 IFT172 ANKRD28 CHD1 PSMD13 NCSTN ESPL1 DDOST

1.04e-06974881328675297
Pubmed

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

SEL1L HSP90B1 FKBP9 NCSTN GNS

1.06e-067188512754519
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

BPTF HSP90B1 IGF2BP2 LIPA TCERG1 INTS11 RBM14 SRP68 SMARCE1 HRNR CNOT1 GNS DDOST

3.30e-061082881338697112
Pubmed

Identification of a region within SEL1L protein required for tumour growth inhibition.

SEL1L SEL1L2

6.33e-06288214729273
Pubmed

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors.

ENTPD1 ITGAE

6.33e-06288230006565
Pubmed

Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies.

GLDN OLFM1

6.33e-06288226121352
Pubmed

CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden.

ENTPD1 ITGAE

6.33e-06288236792124
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

BPTF IGF2BP2 TCERG1 RAB3IP RBM14 SMARCE1 CHD1 DDOST

1.00e-0541188835182466
Pubmed

Interactome of the Autoimmune Risk Protein ANKRD55.

AARS1 HSP90B1 PI4KA RBM14 CNOT1 DDOST

1.13e-0519788631620119
Pubmed

Cadherins Interact With Synaptic Organizers to Promote Synaptic Differentiation.

CDH6 CDH10

1.90e-05388229760652
Pubmed

Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy.

ABL1 ESPL1

1.90e-05388226087013
Pubmed

PROK2, HRNR, and FIG4 as potential genetic biomarkers of high bleeding propensity in East Asian patients with acute coronary syndrome using ticagrelor.

FIG4 HRNR

1.90e-05388236263704
Pubmed

The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.

DNAAF5 MINDY3 LIPA FKBP9 SRP68 AJUBA CNOT1

1.94e-0532588736168628
Pubmed

Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.

APPBP2 TRIM26 VAMP7 SRP68 ANKRD28 CHD1

2.57e-0522888630471916
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

SEL1L DNAAF5 SCO2 AARS1 PI4KA VAMP7 SRP68 NCSTN ESPL1 DDOST NDUFV3

2.60e-05942881131073040
Pubmed

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

SCO2 SRP68 CHD1 PSMD13 ITGAE DDOST

2.77e-0523188636597993
Pubmed

High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes.

OLFM3 OLFM1 OLFM2

3.05e-052488322632720
Pubmed

ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas.

ST3GAL6 TRIM26 C1QTNF7 NCSTN ESPL1

3.15e-0514288530232004
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

DNAAF5 HSP90B1 TCERG1 IFT172 RBM14 SRP68 PSMD13 CNOT1 DDOST

3.50e-0563888933239621
Pubmed

Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus.

CDH6 CDH10

3.79e-05488228957665
Pubmed

Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold.

CDH6 CDH10

3.79e-05488230197236
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

SEL1L DNAAF5 HSP90B1 CDC123 SRP68 PSMD13 NCSTN CNOT1 DDOST

4.39e-0565788936180527
Pubmed

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

RBM14 SMARCE1 CTSB RAI1

4.73e-057888428611094
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

NEO1 PTPRG ENTPD5 ANGPTL3 OLFM1 CDH6

5.01e-0525788616335952
Pubmed

Evolutionarily conserved regulators of tau identify targets for new therapies.

SEL1L AARS1 HSP90B1 VAMP7 SRP68 PSMD13 NCSTN DDOST

5.06e-0551688836610398
Pubmed

Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

HSP90B1 NCSTN CTSB

5.45e-052988312643545
Pubmed

OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation.

SEL1L HSP90B1

6.30e-05588224899641
Pubmed

Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.

PTPRG CNTN5

6.30e-05588227539848
Pubmed

Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?

LIPA CTSB

6.30e-05588227997605
Pubmed

The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity.

PSMD13 ESPL1

6.30e-05588214561405
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

SEL1L DNAAF5 SCO2 HSP90B1 IGF2BP2 VAMP7 RBM14 ANKRD28 PSMD13 CTSB CNOT1 GNS DDOST

6.64e-051440881330833792
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

SEL1L SCO2 AARS1 HSP90B1 NEO1 IGF2BP2 TCERG1 FKBP9 SRP68 SMARCE1 CTSB DDOST NDUFV3

7.17e-051451881330550785
Pubmed

Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.

POTEB2 POTEB

9.43e-05688217171436
Pubmed

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.

AARS1 HSP90B1 TRIM26 PI4KA SRP68 PSMD13 CTSB DDOST

1.02e-0457188837167062
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

DNAAF5 AARS1 PTPRG IFT172 RAB3IP VAMP7 RBM14 SRP68 ANKRD28 PCARE PSMD13 CNOT1

1.23e-041321881227173435
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

BPTF IGF2BP2 TCERG1 TRIM26 RBM14 SRP68 ESPL1 CNOT1 DDOST

1.32e-0475988935915203
Pubmed

Characterization of cadherins expressed by murine thymocytes.

CDH6 CDH10

1.32e-0478828620560
Pubmed

A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction.

CDH6 CDH10

1.32e-0478828879495
Pubmed

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin.

HSP90B1 NCSTN

1.32e-04788211943765
Pubmed

Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice.

OLFM3 OLFM1 OLFM2

1.34e-043988324095980
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

AARS1 HSP90B1 IGF2BP2 TCERG1 PI4KA INTS11 RBM14 SRP68 ANKRD28 CHD1 PSMD13 DDOST

1.53e-041353881229467282
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

HSP90B1 IGF2BP2 TRIM26 RBM14 SRP68 SMARCE1 CHD1 PSMD13 NCSTN POTEJ HRNR

1.57e-041153881129845934
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

SEL1L HSP90B1 ANKRD28 NCSTN HRNR CTSB GNS DDOST

1.66e-0461388822268729
Pubmed

Oct4 links multiple epigenetic pathways to the pluripotency network.

BPTF TCERG1 SRP68 SMARCE1 CNOT1

1.71e-0420388522083510
Pubmed

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.

PRR12 IGF2BP2 SMARCE1 CHD1

1.74e-0410988433554859
Pubmed

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.

SEL1L HSP90B1

1.75e-04888218264092
Pubmed

Purification and characterization of the human gamma-secretase complex.

NCSTN CTSB

1.75e-04888215274632
Pubmed

A protein interaction landscape of breast cancer.

DNAAF5 PI4KA RAB3IP SRP68 ANKRD28 SMARCE1 AMOTL2 AJUBA

2.09e-0463488834591612
Pubmed

Characterization of LGALS3 (galectin-3) as a player in DNA damage response.

NCSTN HRNR DDOST

2.20e-044688324755837
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

SEL1L B3GALNT1 HSP90B1 FKBP9 OLFM1 SMARCE1 NCSTN PRSS23 SEZ6L2 GNS DDOST

2.24e-041201881135696571
Pubmed

Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.

IGF2BP2 CDC123

2.25e-04988222923468
Pubmed

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.

BPTF CHD1

2.25e-04988216728976
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

AARS1 HSP90B1 TCERG1 PI4KA INTS11 RBM14 SRP68 SMARCE1 CHD1 PSMD13 CNOT1 DDOST

2.47e-041425881230948266
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

BPTF AARS1 IGF2BP2 SRP68 ANKRD28 CHD1 CNOT1 RAI1

2.54e-0465388822586326
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

BPTF AARS1 HSP90B1 RBM14 SRP68 PSMD13 CNOT1

2.63e-0449488726831064
Pubmed

Interaction network of human early embryonic transcription factors.

PRR12 BPTF HSP90B1 SMARCE1 HRNR RAI1

2.74e-0435188638297188
Pubmed

Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.

CDH6 CDH10

2.81e-04108822059658
Pubmed

Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.

CDH6 CDH10

2.81e-041088210861224
Pubmed

GINS complex protein Sld5 recruits SIK1 to activate MCM helicase during DNA replication.

APPBP2 SIK1

2.81e-041088227592030
Pubmed

Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy.

DNASE2B OLFM1

2.81e-041088222095909
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

PRR12 HSP90B1 IGF2BP2 TCERG1 RBM14 SRP68 SMARCE1 CHD1 DDOST

2.97e-0484788935850772
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

HSP90B1 IGF2BP2 PTPRG PI4KA INTS11 ANKRD28 PSMD13 AJUBA CNOT1 DDOST

3.21e-041049881027880917
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

HSP90B1 IGF2BP2 TCERG1 TRIM26 RBM14 SRP68 PSMD13 PRSS23 HRNR AJUBA DDOST

3.30e-041257881136526897
Pubmed

The shieldin complex mediates 53BP1-dependent DNA repair.

PRR12 SCO2 NCSTN

3.94e-045688330022168
Pubmed

Comparative analysis of type II classic cadherin mRNA distribution patterns in the developing and adult mouse somatosensory cortex and hippocampus suggests significant functional redundancy.

CDH6 CDH10

4.11e-041288222102170
Pubmed

Inhibition of N-glycan processing modulates the network of EDEM3 interactors.

SEL1L HSP90B1 DDOST

4.15e-045788328366632
Pubmed

Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.

AARS1 IGF2BP2 TCERG1 PI4KA RBM14 PSMD13 CNOT1 DDOST

4.32e-0470788819738201
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

PRR12 BPTF AARS1 IGF2BP2 TCERG1 RBM14 SRP68 SMARCE1 CNOT1 RAI1

4.76e-041103881034189442
Pubmed

Enforced expression of the transcription factor HOXD3 under the control of the Wnt1 regulatory element modulates cell adhesion properties in the developing mouse neural tube.

OLFM1 CDH6

4.85e-041388221929743
Pubmed

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.

BMPR1B NEO1

4.85e-041388218326817
Pubmed

Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex.

HSP90B1 SMARCE1

4.85e-041388211726552
Pubmed

Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice.

OLFM1 OLFM2

4.85e-041388225218043
Pubmed

Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.

ABL1 PI4KA CTSB TENM2 DDOST

5.04e-0425788530945288
Pubmed

Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.

ABL1 TCERG1

5.65e-04148828605874
Pubmed

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

IGF2BP2 OLFM3 OLFM2 TENM2

5.71e-0414988425231870
Pubmed

Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.

HSP90B1 CDC123 PI4KA PSMD13 CNOT1 DDOST

6.06e-0440888633766124
Pubmed

Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse.

CDH6 CDH10

6.51e-041588233833667
Pubmed

Trio controls the mature organization of neuronal clusters in the hindbrain.

ABL1 CDH6

6.51e-041588217898204
Pubmed

Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control.

SEL1L DDOST

6.51e-041588221857022
Pubmed

Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.

PRTG RBM14 SRP68 ANKRD28

6.78e-0415688429961565
Pubmed

A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain.

CHD1 NCSTN AMOTL2

6.97e-046888322779921
Pubmed

Cadherin expression in the developing mouse olfactory system.

CDH6 CDH10

7.42e-041688217278136
Pubmed

Genome-wide association study of recurrent early-onset major depressive disorder.

PTPRG PCARE

7.42e-041688220125088
Pubmed

Aerobic glycolysis tunes YAP/TAZ transcriptional activity.

HSP90B1 HRNR AMOTL2 AJUBA

7.80e-0416288425796446
Pubmed

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.

SEL1L B3GALNT1 HSP90B1 NCSTN

8.17e-0416488432409323
Pubmed

Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.

IGF2BP2 CDC123

8.40e-041788219741467
Pubmed

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

IGF2BP2 CDC123

8.40e-041788219502414
Pubmed

ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.

AARS1 HSP90B1 RBM14 HRNR

8.54e-0416688435687106
Pubmed

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.

BPTF AARS1 HSP90B1 SRP68 SMARCE1 PSMD13 HRNR DDOST

8.61e-0478688829128334
Pubmed

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

SEL1L B3GALNT1 GLDN OLFM3 CST9L ANGPTL3 PRSS23 SEZ6L2 CPED1

8.75e-0498588912975309
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

IGF2BP2 RBM14 SRP68 SMARCE1 HRNR DDOST RAI1

8.76e-0460588728977666
Pubmed

Human transcription factor protein interaction networks.

PRR12 BPTF IGF2BP2 TCERG1 SRP68 ANKRD28 SMARCE1 PSMD13 HRNR CNOT1 DDOST

9.55e-041429881135140242
Pubmed

Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.

IGF2BP2 CDC123

1.05e-031988220161779
Pubmed

Clinical risk factors, DNA variants, and the development of type 2 diabetes.

IGF2BP2 CDC123

1.05e-031988219020324
Pubmed

EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning.

SEL1L HSP90B1

1.05e-031988233671632
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTEJ POTEB2 POTEB

7.46e-0613553685
GeneFamilyAnkyrin repeat domain containing

TRPV1 ANKRD28 ANKRD18A POTEJ POTEB2 POTEB

9.05e-05242556403
GeneFamilyCD molecules|Type II classical cadherins

CDH6 CDH10

6.94e-04135521186
GeneFamilyFibronectin type III domain containing

PRTG NEO1 PTPRG CNTN5

1.42e-03160554555
CoexpressionAtlasdev gonad_e11.5_M_GonadVasMes_Flk_top-relative-expression-ranked_1000

NEO1 IGF2BP2 GLDN ABL1 PTPRG CST9L FKBP9 SMARCE1 C1QTNF7 CPED1 CDH6 CDH10 FREM1

2.39e-058278513gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_1000
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_500

PRTG BMPR1B GLDN ST3GAL6 RAB3IP KCNJ16 PRSS23 CDH6 FREM1

3.06e-05398859gudmap_kidney_P4_CapMesRenVes_Crym_500
CoexpressionAtlasdev gonad_e11.5_M_GonadVasMes_Flk_top-relative-expression-ranked_500

IGF2BP2 GLDN CST9L FKBP9 C1QTNF7 CPED1 CDH6 CDH10 FREM1

4.48e-05418859gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_500
CoexpressionAtlasDevelopingKidney_e15.5_Podocyte cells_emap-27915_k-means-cluster#1_top-relative-expression-ranked_500

PRTG ST3GAL6 ANKRD28 PRSS23 FREM1

8.03e-05110855gudmap_developingKidney_e15.5_Podocyte cells_500_k1
ToppCellnormal_Lymph_Node-B_lymphocytes-MALT_B_cells|normal_Lymph_Node / Location, Cell class and cell subclass

SEL1L HSP90B1 ANKRD28 IGLV5-48 DDOST PDZRN4

2.13e-061908861f907016980ccfbf089e354d91d931771e8a83e0
ToppCellsevere-Plasmablast|World / disease stage, cell group and cell class

AARS1 HSP90B1 ENTPD1 ANKRD28 SIK1 DDOST

2.40e-0619488649e8f90db571a89b8a26aef31fcacd66429fed11
ToppCell(2)_B_cells-(2)_Plasma_cells|(2)_B_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

SEL1L AARS1 HSP90B1 ANKRD28 DDOST NDUFV3

2.55e-06196886cc4f59b885d58e43471e85c51d8e366e68d10846
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_immature_3|E16.5-samps / Age Group, Lineage, Cell class and subclass

NEO1 GLDN ANGPTL3 C1QTNF7 FREM1

1.17e-05149885651494e84be03dc7b061ebdfa91756a1c507b9b4
ToppCellBasal_cells-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

AQP10 OLFM2 PRSS23 TENM2 DDOST

1.80e-05163885679e25e5548d157d49a73057a3b5617dccda260f
ToppCellTCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue-Endometrium|TCGA-Endometrium / Sample_Type by Project: Shred V9

ABCC9 SEL1L2 C1QTNF7 CPED1 PDZRN4

2.21e-05170885cdc19013da7c41d1ed8400a6a643e4c684ff9912
ToppCellTCGA-Endometrium-Solid_Tissue_Normal|TCGA-Endometrium / Sample_Type by Project: Shred V9

ABCC9 SEL1L2 C1QTNF7 CPED1 PDZRN4

2.21e-051708850bde0a40440c7fdf7ba89cac8831d4014e7a4807
ToppCellTCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue|TCGA-Endometrium / Sample_Type by Project: Shred V9

ABCC9 SEL1L2 C1QTNF7 CPED1 PDZRN4

2.21e-05170885516b38c4ecf6b0b04c5d4f80c510dcc00b328c6f
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CPED1 TENM2 CDH6 FREM1 PDZRN4

2.27e-051718854ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DPP6 ST3GAL6 PCARE TENM2 CDH10

2.34e-05172885381ae1c3c07d0a424f43455ec571653b192a946a
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L5-6_FEZF2_ANKRD20A1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

OLFM3 ABCC9 ANKRD18A CDH6 PDZRN4

2.47e-0517488599eb5e1aee136c7039e23b68a43a0fa3d775859f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DPP6 ST3GAL6 PCARE TENM2 CDH10

2.47e-05174885dbdcdec08f1fc69fcdb5d8a6d78df8ef9c374d89
ToppCellwk_08-11-Epithelial-PNS-FGFBP2+_Neural_progenitor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

AQP10 ST3GAL6 OLFM1 CDH6 PDZRN4

2.68e-0517788515a5c96ea840376e54933ebe7a8334a11d9ce411
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

OLFM3 ABCC9 ANKRD18A CDH6 PDZRN4

2.68e-05177885bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCell10x5'v1-week_12-13-Mesenchymal_osteo-stroma-osteochondral_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FKBP9 PRSS23 AMOTL2 SEZ6L2 PDZRN4

2.83e-0517988598c0c5c8034ae8a4b3ceea7fd1d0386ee5f89d09
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

OLFM3 ABCC9 ANKRD18A CDH6 PDZRN4

2.90e-05180885b514c55e52b46e8a1a2f09ed2c59a7683367a505
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ABCC9 ANKRD18A CDH6 FREM1 PDZRN4

2.90e-05180885e8841ef1239f9ee73ac4f4e11faca0742694f368
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

OLFM3 ABCC9 ANKRD18A CDH6 PDZRN4

2.98e-0518188508f44323bf71b6004a921bbc969c954c75feeb66
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ABCC9 ANKRD18A CDH6 FREM1 PDZRN4

3.06e-0518288572e65a23cd36085bc880087d3cae92395de918a1
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

PRTG PTPRG ABCC9 C1QTNF7 FREM1

3.22e-0518488567164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BMPR1B ABCC9 OLFM2 AMOTL2 CDH6

3.31e-0518588535d39a1d04c871edcfb749653538dc5fd0054281
ToppCellnormal_Lung-B_lymphocytes-MALT_B_cells|B_lymphocytes / Location, Cell class and cell subclass

SEL1L HSP90B1 ANKRD28 IGLV5-48 DDOST

3.40e-05186885f4d72463c5f287da6436287eda0a349b4185841e
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_B_plasma-Plasma_cells|lymph-node_spleen / Manually curated celltypes from each tissue

SEL1L ANKRD28 IGLV5-48 DDOST PDZRN4

3.57e-05188885c7b1807c96f87fbcd37739a159cf00f9a1ff5d71
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DPP6 ST3GAL6 PCARE TENM2 CDH10

3.57e-051888859db778c1d9e622a68337212296e3a1ed8f771fa5
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DPP6 ST3GAL6 PCARE TENM2 CDH10

3.57e-05188885047c4e0b03fc8334e38c48977e41d26dbe229d47
ToppCellfacs-Skin-nan-18m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GALNT1 GLDN ENTPD1 C1QTNF7 CPED1

3.66e-0518988529287525120be2953b76881ba3cfc4379c265e7a
ToppCellfacs-Skin-nan-18m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GALNT1 GLDN ENTPD1 C1QTNF7 CPED1

3.66e-051898857150dad9a92a715487c2d8130fa01b752ea69663
ToppCellfacs-Skin-nan-18m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GALNT1 GLDN ENTPD1 C1QTNF7 CPED1

3.66e-051898856e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCellStriatum-Endothelial|Striatum / BrainAtlas - Mouse McCarroll V32

ABCC9 C1QTNF7 PRSS23 AJUBA CPED1

3.66e-0518988595ee3b6d7fbbfcf91c780dfcd0926acec05f0a2d
ToppCellControl-Endothelial-VE_Venous|Endothelial / Disease state, Lineage and Cell class

BMPR1B PTPRG ENTPD1 PRSS23 PDZRN4

3.76e-051908854e30155203b4a8c5e496fcbe9348b67b98ebc625
ToppCellPBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SEL1L AARS1 HSP90B1 ENTPD1 DDOST

3.76e-0519088584eb7761f537d270673909a71d4f122e826769d5
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-Plasma_cell-B_c05-MZB1-XBP1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

HSP90B1 BMPR1B ENTPD1 ANKRD28 DDOST

3.76e-05190885f85cdd79eefd699ada7a91bf4997cc730a9b9846
ToppCellMyeloid-Myeloid-B_(Activated_Macrophage)|Myeloid / shred on cell class and cell subclass (v4)

HSP90B1 LIPA PSMD13 CTSB GNS

3.85e-051918857bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|PND01-03-samps / Age Group, Lineage, Cell class and subclass

NEO1 FKBP9 C1QTNF7 CPED1 FREM1

3.85e-05191885e7c605b56934d1383237c1f946dbccef25d91368
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCC9 C1QTNF7 CPED1 TENM2 CDH6

3.85e-0519188508042952431ca1a6fd7dfc13f36eb28643979598
ToppCellPND14-Mesenchymal-Mesenchymal_structural|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NEO1 FKBP9 GPSM2 CPED1 FREM1

3.95e-0519288525492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCellCOVID-19_Severe-Lymphoid_P|COVID-19_Severe / Disease group, lineage and cell class

SEL1L AARS1 HSP90B1 ENTPD1 DDOST

3.95e-051928853d0240491296757b3125f6e861bbaca06bbc5068
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NEO1 FKBP9 GPSM2 CPED1 FREM1

3.95e-05192885de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCellCOVID-19_Severe-Lymphoid_P-Plasmablast|COVID-19_Severe / Disease group, lineage and cell class

SEL1L AARS1 HSP90B1 ENTPD1 DDOST

3.95e-0519288590af8dad4e6f80b5ecd62027deeb2e4cea6b24bb
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-plasma_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEL1L HSP90B1 ENTPD1 SIK1 CPED1

3.95e-051928856417468829517a0f6e04e7e44eec1622001d4c5c
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGF2BP2 ST3GAL6 OLFM1 CTSB CPED1

4.05e-051938856b3a2a32ec6dc96230cee4bbf03932f8a81e6683
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IGF2BP2 ST3GAL6 OLFM1 CTSB CPED1

4.05e-05193885b18c61e360f5f094f260007a56b189e2a48369e4
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GPSM2 C1QTNF7 CPED1 CDH10 FREM1

4.05e-05193885fb28717fadd06c3840636d25409ce80c9254bd34
ToppCellCOVID-19_Severe-Plasmablast|COVID-19_Severe / disease group, cell group and cell class

SEL1L AARS1 HSP90B1 ENTPD1 DDOST

4.05e-051938858074bcede261b85f9ae03ee372bd6d4b40384537
ToppCellPND07-28-samps-Mesenchymal|PND07-28-samps / Age Group, Lineage, Cell class and subclass

NEO1 FKBP9 C1QTNF7 CPED1 FREM1

4.15e-0519488568bcc1fe8dc8d5f23a12154fc9b41362fdef0b1d
ToppCellIPF-Endothelial-VE_Venous|Endothelial / Disease state, Lineage and Cell class

BMPR1B PTPRG ENTPD1 PRSS23 PDZRN4

4.15e-05194885e8a9005963704286bcc50785bda8d7d63ec001b1
ToppCellnormal_Lymph_Node-B_lymphocytes-MALT_B_cells|B_lymphocytes / Location, Cell class and cell subclass

SEL1L HSP90B1 ST3GAL6 ANKRD28 DDOST

4.15e-051948851ca034f25a8fce503fb67654d7fa2a8ec71976be
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NEO1 FKBP9 C1QTNF7 CPED1 FREM1

4.25e-05195885cbe518b465b4ef32797ae6b608219207c08493df
ToppCellPND03-Mesenchymal-Mesenchymal_structural|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NEO1 FKBP9 C1QTNF7 CPED1 FREM1

4.25e-05195885136b06b0931a69b1241101f68c01c44c70365fd9
ToppCellsevere-Plasmablast|severe / disease stage, cell group and cell class

AARS1 HSP90B1 ENTPD1 ANKRD28 DDOST

4.25e-05195885e11616ad568e50e4c720b50b0c071f484c31d16b
ToppCellMild/Remission-Plasmablast|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SEL1L HSP90B1 ENTPD1 ANKRD28 DDOST

4.25e-0519588552bdd609253613b7db75dccbc1c01c05e8d73f79
ToppCell(6)_Macrophage-(61)_LYVE1_Macrophage|(6)_Macrophage / shred on Cell_type and subtype

SCO2 GLDN PRSS23 DDOST

4.29e-059888430a9a2abd0487e818628db589d31f630ca4d894b
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast|PND01-03-samps / Age Group, Lineage, Cell class and subclass

NEO1 FKBP9 C1QTNF7 CPED1 FREM1

4.36e-0519688554f4cf778f95a9ff662e5c7520916a25e605bf95
ToppCellSevere-Plasmablast|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SEL1L HSP90B1 ENTPD1 ANKRD28 DDOST

4.36e-05196885ee991f1d9936c656f4fbc2e0cec9e0166a34bc5b
ToppCellMild/Remission-Plasmablast|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SEL1L HSP90B1 ENTPD1 ANKRD28 DDOST

4.36e-05196885dcf0a804a79a05454658498d1f87320c7e079219
ToppCellSevere-Plasmablast|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SEL1L HSP90B1 ENTPD1 ANKRD28 DDOST

4.46e-051978851089aa7991812378668d0f3d57f8000e6245a713
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SEL1L AARS1 HSP90B1 ENTPD1 DDOST

4.46e-051978851e63879633f20646e44873ae6b662f6faf4806fd
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPP6 BMPR1B OLFM1 OLFM2 SEZ6L2

4.46e-05197885f7eaac1c321710a55e09ffb047a7db2baf7b7e28
ToppCellCOVID_vent-Lymphocytic-Plasma_cell-IgA_Plasmablast|COVID_vent / Disease condition, Lineage, Cell class and subclass

SEL1L AARS1 HSP90B1 ENTPD1 DDOST

4.46e-0519788599fe44ef42c65d24fe64947fd5bf6d91b9a4b2c3
ToppCellCOVID-19-COVID-19_Convalescent-Others-HSPC|COVID-19_Convalescent / Disease, condition lineage and cell class

B3GALNT1 AQP10 IGF2BP2 ANKRD28 CPED1

4.46e-05197885c1033a1a8b8b5c8569130aa9405a6e8e65ef7bd0
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell-IgA_Plasmablast|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SEL1L AARS1 HSP90B1 ENTPD1 DDOST

4.46e-05197885fdbf4eb9fa5aefb4ffb307494fe4774bf5e0aaeb
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPP6 BMPR1B OLFM3 OLFM1 OLFM2

4.57e-0519888585881637641d8996be2edc65c4bceff0433135e7
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DPP6 PRTG PTPRG ST3GAL6 ABCC9

4.57e-05198885f948391296c261c473d339069a6d0f20ccd6f38f
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MGAM ENTPD1 ESPL1 CTSB CPED1

4.57e-05198885732a43061d75bc5e1cf23f5056b72cd10c926668
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-cortical_neurons_1|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

DPP6 NEO1 OLFM1 OLFM2 SEZ6L2

4.57e-05198885d81f35c0066558ff96dd06f58fca72cd82e681e8
ToppCellsevere-HLA-DR+_CD83+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ENTPD1 ANGPTL3 ANKRD28 CPED1 GNS

4.57e-05198885d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-B-Plasmablast|COVID-19_Severe / Disease, condition lineage and cell class

SEL1L AARS1 HSP90B1 ENTPD1 DDOST

4.68e-05199885e6422b65e22e5aa8dfaebdae5be76dd78b978604
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Pericyte|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ABCC9 OLFM2 AJUBA CPED1 CDH6

4.79e-052008854e1e19214aeebbdca004de7faaf4cc9d18498591
ToppCellcontrol-HLA-DR-_S100A+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LIPA ST3GAL6 ENTPD1 CTSB GNS

4.79e-05200885107a0665fb20247511a430178effd7630a619488
ToppCellcontrol-Neutrophil|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LIPA ST3GAL6 OLFM1 CTSB GNS

4.79e-05200885251ca08fab5cc2a4e280db6a6286a9ebaef3e61a
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte|Control_saline / Treatment groups by lineage, cell group, cell type

ABCC9 PRSS23 CPED1 TENM2 CDH6

4.79e-05200885cb7ef774b6d300f8019c5b16a04e3ebd165e4f1c
ToppCellnormal_Pleural_Fluid-Myeloid_cells-Pleural_Mac|Myeloid_cells / Location, Cell class and cell subclass

SCO2 HSP90B1 LIPA CTSB GNS

4.79e-05200885bffebc281a5c1c2bfdb2696a45343787289fc374
ToppCell(2)_B_cell-(21)_B_cell_IgG_Plasma|(2)_B_cell / shred on Cell_type and subtype

SEL1L AARS1 HSP90B1 ANKRD28 DDOST

4.79e-052008852831060d52b210f8927527810611735a99b61999
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PTPRG ABCC9 CPED1 FREM1 PDZRN4

4.79e-052008850c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell(21)_B_cell_IgG_Plasma|World / shred on Cell_type and subtype

SEL1L AARS1 HSP90B1 ANKRD28 DDOST

5.15e-0520388515055e1b1017afbdb2a567972cbb976deb7d4e6a
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3|Hippocampus / BrainAtlas - Mouse McCarroll V32

ANGPTL3 ABCC9 C1QTNF7 AJUBA

1.14e-04126884b0bc61be1d4ce8114077c524fedfdf89128bcf12
ToppCellTCGA-Cervix-Solid_Tissue_Normal-Cervical_normal_tissue-Cervical_normal_tissue|TCGA-Cervix / Sample_Type by Project: Shred V9

DPP6 ABCC9 SEL1L2 C1QTNF7

1.62e-04138884d3d16b043024914475a5e3db0803be0d4678c165
ToppCellTCGA-Cervix-Solid_Tissue_Normal-Cervical_normal_tissue-Cervical_normal_tissue-5|TCGA-Cervix / Sample_Type by Project: Shred V9

DPP6 ABCC9 SEL1L2 C1QTNF7

1.62e-04138884d1efb4ef05aba89dd46ce698c5ce359fe8ab41c1
ToppCellTCGA-Cervix-Solid_Tissue_Normal|TCGA-Cervix / Sample_Type by Project: Shred V9

DPP6 ABCC9 SEL1L2 C1QTNF7

1.62e-041388843bb5d4c23335866d41e8e99db0676ee5799e5aff
ToppCellTCGA-Cervix-Solid_Tissue_Normal-Cervical_normal_tissue|TCGA-Cervix / Sample_Type by Project: Shred V9

DPP6 ABCC9 SEL1L2 C1QTNF7

1.62e-04138884c4f6381977d39ad3f7e1e1fa1217a802e8804132
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

DPP6 CNTN5 CDH6 PIWIL3

1.66e-04139884a1945b07f177cde40e7eea03a19236ce76165857
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Alveolar_Mac|metastatic_Lymph_Node / Location, Cell class and cell subclass

DNASE2B LIPA GLDN CTSB

2.52e-0415588403fd443740272dcb547e39deaf7ae89b8307f241
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN5 ANGPTL3 CPED1 PDZRN4

2.59e-04156884d5207dbfbcfb885557ea1378dfe6a56d7102e94a
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN5 ANGPTL3 CPED1 PDZRN4

2.59e-04156884363f1b661048d25895e2b8681c82894c957b29c0
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

ABCC9 CPED1 CDH6 PDZRN4

2.71e-041588848d64c0c9de910a3f4658778642d183c8b9b6f6a2
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

CNTN5 SEL1L2 TENM2 PDZRN4

2.78e-041598845335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GLDN ABCC9 CPED1 PDZRN4

2.78e-04159884cfb4a8c8aac34b1a857956d98382d487abcf5444
ToppCelltumor_Lymph_Node_/_Brain-B_lymphocytes-MALT_B_cells|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

HSP90B1 ANKRD28 IGLV5-48 PDZRN4

2.78e-04159884204e5a675f4684c9570c24c8d34bbf632fd8164a
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GLDN ABCC9 CPED1 PDZRN4

2.78e-04159884a75ab494959575143cefdaec99e7aee3f318d559
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW12-Neuronal-Neurons|GW12 / Sample Type, Dataset, Time_group, and Cell type.

OLFM1 SEZ6L2 CDH6

2.89e-04658833c094b098edc216b0bb23a5cbce7950e27713782
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.C1ql3_(VTA_(dorsal_VTA))-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ANGPTL3 ITGAE FREM1

2.89e-04658834382d56d5f71c7acfe35f84db7257aba2a7dd36a
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.C1ql3_(VTA_(dorsal_VTA))|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ANGPTL3 ITGAE FREM1

2.89e-046588305b712f83d88e864747cd0229a39aca17321e0f8
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

NEO1 PTPRG ABCC9 SEZ6L2

2.98e-041628842259e9536147e9cdee772e3a30ba7d104573262c
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ABCC9 ANKRD18A CDH6 PDZRN4

3.06e-04163884d7057ae155058a13f3d7c3db5c7fbc3bb2b69376
ToppCell10x3'2.3-week_14-16-Myeloid_macrophage-stroma-erythroid_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LIPA SIK1 CTSB TENM2

3.06e-04163884240d9f0ea45e8b2c7173e7674fd740555810f9e7
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ABCC9 ANKRD18A CDH6 PDZRN4

3.06e-0416388455fd4f21c7a8bea031fb6f7f2c8cc1ff42b00d79
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3_(Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

GLDN SEL1L2 FREM1

3.16e-0467883e53dfc288c943656a0b064afe593ea2101d75437
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3_(Neuron.Gad1Gad2-Slc17a8.Synpr-Sncg-Yjefn3)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

GLDN SEL1L2 FREM1

3.16e-04678831841cee311a4b1b802c9e872793435afb730592f
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

BMPR1B AMOTL2 CDH6 PDZRN4

3.27e-04166884f416d8a322f086c769659a9fab6b460a2d546ab1
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

IGF2BP2 PTPRG C1QTNF7 LCT

3.27e-0416688494636dbc039f794c735960c3425e00bdd5523602
Diseasewaist-hip ratio

BPTF APPBP2 BMPR1B IGF2BP2 ANKRD19P PTPRG CNTN5 ANKRD28 C1QTNF7 OLFM2 CPED1 PDZRN4

1.59e-0412268312EFO_0004343
Diseaselifestyle measurement, maximum cigarettes per day measurement

GLDN OLFM3 PRSS23 AMOTL2

3.97e-04122834EFO_0009264, EFO_0010724
Diseasetotal brain volume change measurement

DPP6 CNTN5

6.96e-0414832EFO_0021504
DiseaseEye Abnormalities

BMPR1B FREM1

1.03e-0317832C0015393
Diseaseage at menarche

B3GALNT1 IGF2BP2 OLFM3 PTPRG CNTN5 OLFM2 TENM2

1.43e-03594837EFO_0004703
DiseaseAutism Spectrum Disorders

DPP6 CDH10 RAI1

1.80e-0385833C1510586
DiseaseCharcot-Marie-Tooth disease (implicated_via_orthology)

AARS1 FIG4

2.07e-0324832DOID:10595 (implicated_via_orthology)
DiseaseBone Diseases, Developmental

BMPR1B ABL1

2.62e-0327832C0005941

Protein segments in the cluster

PeptideGeneStartEntry
SKHSDYINANYVDGY

PTPRG

901

P23470
TYEEAKAHSQYYAAQ

AMOTL2

106

Q9Y2J4
DIYGNTALHYAVYNK

ANKRD18A

131

Q8IVF6
QDKHYGYNSYSVSNS

CTSB

221

P07858
YSDFLLYKSGVYQHV

CTSB

256

P07858
YHNVNGGKTLISYSY

CPED1

806

A4D0V7
SNQVYCVTDYHKNYA

AJUBA

446

Q96IF1
GATYVLYHDALQNYT

AQP10

116

Q96PS8
RDKQGYNAVHYSAAY

ANKRD28

501

O15084
VYNNSLYYHKGGSNT

GLDN

376

Q6ZMI3
EYSINNTGKADQTYY

ABCC9

1021

O60706
NKHYIEYSFYLGNHE

ANGPTL3

341

Q9Y5C1
LAYSSYVHQYSSGKF

APPBP2

336

Q92624
GKYRVYHNQYSTNSF

BPTF

846

Q12830
YHENGSLYDYLKSTT

BMPR1B

281

O00238
YYSNFISHLANIKYP

CA6

176

P23280
AHSNQKSAAGYPDYY

CHD1

396

O14646
DIYSNTALHYAVYNK

ANKRD19P

131

Q9H560
YYSPINLYHSSDAFK

CNTN5

76

O94779
ETLHYQNLAKYQHYG

RAI1

301

Q7Z5J4
SYNDYLRAAQMHSGY

RBM14

651

Q96PK6
KIRNHGEYDLYYSSS

PDZRN4

636

Q6ZMN7
HVVYNGSLFYNKYQS

OLFM2

271

O95897
HRIKLGDSSNYYYIS

RAB3IP

406

Q96QF0
GAFHNKYYQSIYDTA

NCSTN

446

Q92542
YGNTALHYAIYNEDK

POTEB2

201

H3BUK9
TVYHYNGLKQSNYNE

MINDY3

381

Q9H8M7
FNSTYKLYTHSYLGF

ENTPD5

231

O75356
SQLGNAYFYLHDYAK

GPSM2

66

P81274
YFSTGLTEKANHYYK

INTS11

266

Q5TA45
YYSKNHSYHVEGNLV

MGAM

131

O43451
DNYSYRGFYQKTHIS

B3GALNT1

211

O75752
AQYSYLGYAVAVLHK

ITGAE

456

P38570
GTKVHYAYQTNASTY

OLFM1

421

Q99784
SSVYRNGTDIIYNYH

FREM1

1936

Q5H8C1
YQYATQHGEYDTLNK

HRNR

16

Q86YZ3
YSHLVSVGYDYHQAK

PMS2P3

41

Q13401
LYKYHSQYHTVAGND

PI4KA

521

P42356
NHYTTVLAYNLNYAT

LCT

1681

P09848
SGHQFENYSFKISYI

IGF2BP2

141

Q9Y6M1
YDLSSKYYQTIGNHA

PSMD13

156

Q9UNM6
KYYQTIGNHASYYKD

PSMD13

161

Q9UNM6
YNVYTHSFLCYGKDQ

ENTPD1

246

P49961
KVDYNRLGYTHLYSS

DDOST

391

P39656
ASKYYPLVAQHYASL

IFT172

911

Q9UG01
SADAKVYSGYYHLDQ

PRTG

931

Q2VWP7
AYQTGKDISTNYYAS

HSP90B1

666

P14625
YLKYHYNASLLDGTL

FKBP9

391

O95302
SNLAYSFYSHKLYAE

ESPL1

461

Q14674
EAYASKSNNTAYLIY

DNASE2B

96

Q8WZ79
SQRDYTQYYDHISKQ

CDC123

191

O75794
EYTGSDYQYVGKLHS

CDH10

66

Q9Y6N8
SYSYDLSHSLQYNLT

FIG4

166

Q92562
VYHYRINTASDGKLY

ABL1

171

P00519
LNNTYIFYTSDNGYH

GNS

316

P15586
YTGSDYQYVGKLHSD

CDH6

66

P55285
GANAKSYYQSSVQYL

DNAAF5

776

Q86Y56
AVQYDNHYTNTKYCL

DUS2

271

Q9NX74
HTFNQQSKDYYAYRL

CST9L

56

Q9H4G1
KANYSLQIYPDESHY

DPP6

811

P42658
DGSKITYIDYYRQQH

PIWIL3

351

Q7Z3Z3
KQVAQASHSYRVYYN

SCO2

196

O43819
GIYYFSYDITLANKH

C1QTNF7

191

Q9BXJ2
VTNSHLTGAKVYYSY

OLFM3

406

Q96PB7
QAYTYLHSSLSKYEA

PCARE

186

A6NGG8
RYLLNYYSDSDKHQG

IGLV5-48

66

A0A075B6I7
KAYHNSPAYLAYINA

SMARCE1

131

Q969G3
TAYNSYKDGDYNAAV

SEL1L

561

Q9UBV2
YQTAATHYSIAANKY

SEL1L2

571

Q5TEA6
YGNTALHYAIYNEDK

POTEB

201

A0A0A6YYL3
AKQYLSYETLYANGS

PRSS23

81

O95084
SHSYTINGLKKYTEY

NEO1

591

Q92859
YGNTTLHYAIYNEDK

POTEJ

201

P0CG39
YNFSDLKSPLHYYGN

ST3GAL6

281

Q9Y274
LQNSSYNHFAAIYYL

SIK1B

326

A0A0B4J2F2
LQNSSYNHFAAIYYL

SIK1

326

P57059
YKTNLGHHLQYFYSD

TENM2

2311

Q9NT68
YNHSNSEITSLYYDL

TENM2

2336

Q9NT68
YQTLYKHHYQAGESL

SEZ6L2

781

Q6UXD5
ELEKSGYYTLYHSLH

PRR12

1961

Q9ULL5
RKFYTSSTHYYGQET

NPAP1

1131

Q9NZP6
GKVSNLQYLHSYLTY

SRP68

371

Q9UHB9
QYSYHDINVYSLAGL

CNOT1

1356

A5YKK6
KYNYHLDSSGSYVFE

AARS1

486

P49588
ADGKTYYYNNRTLES

TCERG1

441

O14776
VNASYTDSYYKGQTA

TRPV1

191

Q8NER1
SSYHIINADAKYPGY

KCNJ16

6

Q9NPI9
TYTSLYKSAYLHPQQ

TRIM26

336

Q12899
NKLTYSHGNYLFHYI

VAMP7

41

P51809
IKHNSDLIYYQGNYV

ZNF713

216

Q8N859
GSSAKNYFHYNQSYP

LIPA

311

P38571
YKNLQHHDYSTYTFL

NDUFV3

71

P56181