Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	CAD CAMK2D CAMK2G SPEG PLK5 LRRK2 CDKL3 POLRMT DGKZ TEX14 POLA2 RYK MAP3K4 PAPOLG TYK2 FAM20C PAPOLA MOCS3 ULK4 TRIB1 MAP4K2	8.13e-06	938	151	21	GO:0016772
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	GPS1 LRRK2 SIRPB1 ARHGEF11 ALS2CL VPS9D1 SBF2 HPS1 RASGEF1C FGD5 TBC1D21 DEPDC1B PLXNB1 RASAL1	3.18e-05	507	151	14	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	GPS1 LRRK2 SIRPB1 ARHGEF11 ALS2CL VPS9D1 SBF2 HPS1 RASGEF1C FGD5 TBC1D21 DEPDC1B PLXNB1 RASAL1	3.18e-05	507	151	14	GO:0030695
GeneOntologyMolecularFunction	protein kinase activity	CAD CAMK2D CAMK2G SPEG PLK5 LRRK2 CDKL3 TEX14 RYK MAP3K4 TYK2 FAM20C ULK4 TRIB1 MAP4K2	5.15e-05	600	151	15	GO:0004672
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	CAD CAMK2D CAMK2G SPEG PLK5 LRRK2 CDKL3 DGKZ TEX14 RYK MAP3K4 TYK2 FAM20C ULK4 TRIB1 MAP4K2	9.61e-05	709	151	16	GO:0016773
GeneOntologyMolecularFunction	kinase activity	CAD CAMK2D CAMK2G SPEG PLK5 LRRK2 CDKL3 DGKZ TEX14 RYK MAP3K4 TYK2 FAM20C ULK4 TRIB1 MAP4K2	2.25e-04	764	151	16	GO:0016301
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	EXOSC9 ERCC3 EP400 EARS2 POLRMT CHD8 POLA2 DTD2 ALKBH5 LCMT2 DIMT1 POP1 PAN2 FDXACB1	3.95e-04	645	151	14	GO:0140640
GeneOntologyMolecularFunction	ligase activity, forming carbon-nitrogen bonds	CAD TTLL5 TPGS1 PFAS	6.90e-04	53	151	4	GO:0016879
Domain	Prot_kinase_dom	CAMK2D CAMK2G SPEG PLK5 LRRK2 CDKL3 TEX14 RYK MAP3K4 TYK2 ULK4 TRIB1 MAP4K2	1.63e-04	489	150	13	IPR000719
Domain	PROTEIN_KINASE_DOM	CAMK2D CAMK2G SPEG PLK5 LRRK2 CDKL3 TEX14 RYK MAP3K4 TYK2 ULK4 TRIB1 MAP4K2	1.76e-04	493	150	13	PS50011
Domain	-	PAPOLG PAPOLA	1.91e-04	3	150	2	3.30.70.590
Domain	NuclTrfase_I_C	PAPOLG PAPOLA	1.91e-04	3	150	2	IPR011068
Domain	PAP_central	PAPOLG PAPOLA	1.91e-04	3	150	2	PF04928
Domain	PAP_RNA-bind	PAPOLG PAPOLA	1.91e-04	3	150	2	PF04926
Domain	PolA_pol_cen_dom	PAPOLG PAPOLA	1.91e-04	3	150	2	IPR007012
Domain	PolA_pol_RNA-bd_dom	PAPOLG PAPOLA	1.91e-04	3	150	2	IPR007010
Domain	PolyA_polymerase	PAPOLG PAPOLA	1.91e-04	3	150	2	IPR014492
Domain	CaMKII_AD	CAMK2D CAMK2G	3.80e-04	4	150	2	PF08332
Domain	P5-ATPase	ATP13A5 ATP13A2	3.80e-04	4	150	2	PF12409
Domain	FAM86	FAM86B1 FAM86B2	3.80e-04	4	150	2	IPR029426
Domain	FAM86	FAM86B1 FAM86B2	3.80e-04	4	150	2	PF14904
Domain	Ca/CaM-dep_prot_kinase-assoc	CAMK2D CAMK2G	3.80e-04	4	150	2	IPR013543
Domain	Kinase-like_dom	CAMK2D CAMK2G SPEG PLK5 LRRK2 CDKL3 TEX14 RYK MAP3K4 TYK2 ULK4 TRIB1 MAP4K2	4.38e-04	542	150	13	IPR011009
Domain	P-type_TPase_V	ATP13A5 ATP13A2	6.31e-04	5	150	2	IPR006544
Domain	FERM_central	MYO7A PTPN21 FRMD4B TYK2	6.39e-04	49	150	4	IPR019748
Domain	FERM_domain	MYO7A PTPN21 FRMD4B TYK2	6.39e-04	49	150	4	IPR000299
Domain	FERM_1	MYO7A PTPN21 FRMD4B TYK2	6.91e-04	50	150	4	PS00660
Domain	FERM_2	MYO7A PTPN21 FRMD4B TYK2	6.91e-04	50	150	4	PS00661
Domain	FERM_3	MYO7A PTPN21 FRMD4B TYK2	6.91e-04	50	150	4	PS50057
Domain	Band_41_domain	MYO7A PTPN21 FRMD4B TYK2	6.91e-04	50	150	4	IPR019749
Domain	B41	MYO7A PTPN21 FRMD4B TYK2	6.91e-04	50	150	4	SM00295
Domain	GATASE_TYPE_1	CAD PFAS	9.41e-04	6	150	2	PS51273
Domain	GATASE	CAD PFAS	9.41e-04	6	150	2	IPR017926
Domain	TPR_11	OGT TTC14	1.31e-03	7	150	2	PF13414
Domain	Carbohydrate_sulfotransferase	CHST5 CHST4	1.31e-03	7	150	2	IPR016469
Domain	zf-TRAF	TRAF4 PDZRN3	1.74e-03	8	150	2	PF02176
Domain	FERM_N	MYO7A PTPN21 FRMD4B	2.32e-03	33	150	3	IPR018979
Domain	FERM_N	MYO7A PTPN21 FRMD4B	2.32e-03	33	150	3	PF09379
Domain	PH_dom-like	MYO7A DOK7 PTPN21 ARHGEF11 FRMD4B TYK2 SBF2 FGD5 PLCG2 RASAL1	2.36e-03	426	150	10	IPR011993
Domain	-	CAD PFAS	2.76e-03	10	150	2	3.40.50.880
Domain	VPS9	ALS2CL VPS9D1	2.76e-03	10	150	2	PS51205
Domain	Ank_3	ANKRD23 ASB18	2.76e-03	10	150	2	PF13606
Domain	VPS9	ALS2CL VPS9D1	2.76e-03	10	150	2	PF02204
Domain	VPS9	ALS2CL VPS9D1	2.76e-03	10	150	2	IPR003123
Domain	NTP_transf_2	PAPOLG PAPOLA	3.36e-03	11	150	2	PF01909
Domain	Polymerase_NTP_transf_dom	PAPOLG PAPOLA	3.36e-03	11	150	2	IPR002934
Domain	Methyltransf_16	FAM86B1 FAM86B2	3.36e-03	11	150	2	IPR019410
Domain	Methyltransf_16	FAM86B1 FAM86B2	3.36e-03	11	150	2	PF10294
Domain	Pkinase	CAMK2D CAMK2G SPEG LRRK2 CDKL3 MAP3K4 ULK4 TRIB1 MAP4K2	3.71e-03	381	150	9	PF00069
Domain	-	LRRK2 DGKZ ANKRD23 TEX14 ANKRD55 ASB18 KANK4	3.95e-03	248	150	7	1.25.40.20
Domain	PROTEIN_KINASE_ATP	CAMK2D CAMK2G SPEG LRRK2 CDKL3 RYK MAP3K4 TYK2 ULK4 MAP4K2	4.01e-03	459	150	10	PS00107
Domain	ABC_A	ABCA3 ABCA13	4.01e-03	12	150	2	IPR026082
Domain	Znf_TRAF	TRAF4 PDZRN3	4.01e-03	12	150	2	IPR001293
Domain	Class_I_gatase-like	CAD PFAS	4.01e-03	12	150	2	IPR029062
Domain	-	MYO7A DOK7 PTPN21 ARHGEF11 FRMD4B SBF2 FGD5 PLCG2 RASAL1	4.39e-03	391	150	9	2.30.29.30
Domain	Ankyrin_rpt-contain_dom	LRRK2 DGKZ ANKRD23 TEX14 ANKRD55 ASB18 KANK4	4.49e-03	254	150	7	IPR020683
Domain	ZF_TRAF	TRAF4 PDZRN3	4.72e-03	13	150	2	PS50145
Domain	-	CAMK2D CAMK2G	4.72e-03	13	150	2	3.10.450.50
Domain	Ankyrin_rpt	LRRK2 DGKZ ANKRD23 TEX14 ANKRD55 ASB18 KANK4	5.31e-03	262	150	7	IPR002110
Domain	-	TRAF4 PDZRN3	5.47e-03	14	150	2	3.90.890.10
Domain	GPCR_3_CS	GABBR2 TAS1R1	5.47e-03	14	150	2	IPR017979
Domain	FERM_M	MYO7A PTPN21 FRMD4B	5.99e-03	46	150	3	PF00373
Domain	NTF2-like_dom	CAMK2D CAMK2G	6.28e-03	15	150	2	IPR032710
Domain	-	MYO7A PTPN21 FRMD4B	7.14e-03	49	150	3	1.20.80.10
Domain	SIAH-type	TRAF4 PDZRN3	7.14e-03	16	150	2	IPR013323
Domain	PINT	GPS1 EIF3C	7.14e-03	16	150	2	SM00088
Domain	-	CHST5 ABCA3 NWD1 ERCC3 THNSL1 EP400 MYO7A ABCA13 LRRK2 SMC4 CHD8 CHST4 NLRP4	7.19e-03	746	150	13	3.40.50.300
Domain	FERM/acyl-CoA-bd_prot_3-hlx	MYO7A PTPN21 FRMD4B	7.55e-03	50	150	3	IPR014352
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EP400 MYO7A SPEG SREBF1 POLRMT PFAS CHD8 ARHGEF11 ATP13A2 SLC29A2 TYK2 RHPN1 FAM20C TRAF4 MROH6 SBF2 ULK4 TRIB1 RASAL1	3.98e-07	1105	152	19	35748872
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	EXOSC9 ERCC3 OGT EP400 CHD8 XPC KHSRP FMNL3 ZBTB7A POP1 EIF3C	2.09e-06	410	152	11	26949251
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	PDS5B OGT EP400 EARS2 SMC4 CHD8 KHSRP PAPOLA BOLA2 EIF3C	2.82e-06	341	152	10	32971831
Pubmed	The sperm-associated antigen 6 interactome and its role in spermatogenesis.	CDKL3 DGKZ NUFIP1 INTS10 INTS2 SNX25 DDHD1 NOL8	2.89e-06	199	152	8	31146259
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	OGT EP400 EARS2 MTHFD2 PLCXD1 POLRMT OBSL1 CHD8 XPC SIRPB1 NCKAP5L NUFIP1 TYK2 INTS10 ZBTB7A DIMT1 PDZRN3	8.43e-06	1116	152	17	31753913
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EXOSC9 CAD ERCC3 OGT EP400 POLRMT SMC4 DGKZ CHD8 XPC ARHGEF11 ALKBH5 LRCH3 INTS10 ZBTB7A DIMT1 INTS2 POP1 EIF3C NOL8	8.99e-06	1497	152	20	31527615
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	PDS5B NWD1 MYO7A SPEG GPS1 POLRMT SMC4 HSF2BP SPG11 ARHGEF11 MAP3K4	1.29e-05	497	152	11	36774506
Pubmed	Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex.	INTS3 INTS10 INTS2	1.32e-05	11	152	3	23904267
Pubmed	Obesity-Induced Upregulation of ZBTB7A Promotes Lipid Accumulation through SREBP1.	SREBF1 ZBTB7A	1.90e-05	2	152	2	31998789
Pubmed	Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance.	CAMK2D CAMK2G	1.90e-05	2	152	2	34303021
Pubmed	Abnormal microsomal detoxification implicated in Fanconi anemia group C by interaction of the FAC protein with NADPH cytochrome P450 reductase.	POR FANCC	1.90e-05	2	152	2	9787138
Pubmed	Differentiation driven changes in the dynamic organization of Basal transcription initiation.	ERCC3 XPC	1.90e-05	2	152	2	19841728
Pubmed	CaM kinase II regulates cardiac hemoglobin expression through histone phosphorylation upon sympathetic activation.	CAMK2D CAMK2G	1.90e-05	2	152	2	31619570
Pubmed	Ischemic Injury-Induced CaMKIIδ and CaMKIIγ Confer Neuroprotection Through the NF-κB Signaling Pathway.	CAMK2D CAMK2G	1.90e-05	2	152	2	29992531
Pubmed	Ca2+/calmodulin-dependent protein kinase II-γ (CaMKIIγ) negatively regulates vascular smooth muscle cell proliferation and vascular remodeling.	CAMK2D CAMK2G	1.90e-05	2	152	2	26567004
Pubmed	Cardiac CaM Kinase II genes δ and γ contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy.	CAMK2D CAMK2G	1.90e-05	2	152	2	25124496
Pubmed	[PI3K/Akt/Erk signaling pathway mediates neuroprotection of CaMKⅡγ and CaMKⅡδ against ischemic reperfusion injury in mice].	CAMK2D CAMK2G	1.90e-05	2	152	2	38597448
Pubmed	Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma.	CHST5 CHST4	1.90e-05	2	152	2	12107080
Pubmed	Activation of JNK signaling in osteoblasts is inversely correlated with collagen synthesis in age-related osteoporosis.	MAP3K4 MAP4K2	1.90e-05	2	152	2	30217450
Pubmed	CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury.	CAMK2D CAMK2G	1.90e-05	2	152	2	25193973
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	EP400 EARS2 RNF44 CHD8 SPG11 FRMD4B FMNL3 INTS2 DDHD1 PAN2 PLXNB1	2.29e-05	529	152	11	14621295
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	OGT GPS1 POLRMT SMC4 OBSL1 DGKZ PFAS PTPN21 NCKAP5L KHSRP TYK2 DIMT1 PTPRM BOLA2 EIF3C	2.60e-05	974	152	15	28675297
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	PDS5B CAD OGT INTS3 KHSRP INTS2 ANGPTL4 ZNF654	2.80e-05	272	152	8	31010829
Pubmed	The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts.	INTS3 INTS10 INTS2	2.88e-05	14	152	3	32697989
Pubmed	Structure of the catalytic core of the Integrator complex.	INTS3 INTS10 INTS2	2.88e-05	14	152	3	33548203
Pubmed	INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.	INTS3 INTS10 INTS2	2.88e-05	14	152	3	32647223
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	THNSL1 OGT SREBF1 POLRMT OBSL1 PFAS CHD8 INTS3 TYK2 DDHD1 POP1 PLXNB1	3.10e-05	650	152	12	38777146
Pubmed	Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.	ERCC3 POLRMT XPC POLA2 FANCC	3.49e-05	84	152	5	19237606
Pubmed	Iris phenotypes and pigment dispersion caused by genes influencing pigmentation.	MYO7A HPS1 RABGGTA	3.58e-05	15	152	3	18715234
Pubmed	Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.	COL7A1 ABCA3 ZSWIM5 MTHFD2 LRRK2 POP1	5.18e-05	149	152	6	22664934
Pubmed	Distinct substrate specificities of human GlcNAc-6-sulfotransferases revealed by mass spectrometry-based sulfoglycomic analysis.	CHST5 CHST4	5.68e-05	3	152	2	30093410
Pubmed	Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate.	CHST5 CHST4	5.68e-05	3	152	2	12218059
Pubmed	Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation.	CAMK2D CAMK2G	5.68e-05	3	152	2	23283722
Pubmed	Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors.	ARHGEF11 PLXNB1	5.68e-05	3	152	2	12220504
Pubmed	Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN).	SREBF1 ZBTB7A	5.68e-05	3	152	2	18682402
Pubmed	Essentiality of Regulator of G Protein Signaling 6 and Oxidized Ca2+/Calmodulin-Dependent Protein Kinase II in Notch Signaling and Cardiovascular Development.	CAMK2D CAMK2G	5.68e-05	3	152	2	29079565
Pubmed	High-resolution arrays reveal burden of copy number variations on Parkinson disease genes associated with increased disease risk in random cohorts.	LRRK2 ATP13A2	5.68e-05	3	152	2	27399248
Pubmed	Down-regulation of LRRK2 in control and DAT transfected HEK cells increases manganese-induced oxidative stress and cell toxicity.	LRRK2 ATP13A2	5.68e-05	3	152	2	23628791
Pubmed	Identification of novel human tumor cell-specific CaMK-II variants.	CAMK2D CAMK2G	5.68e-05	3	152	2	9060999
Pubmed	Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells.	CAMK2D CAMK2G	5.68e-05	3	152	2	10819240
Pubmed	Diacylglycerol Kinase ζ (DGKζ) Is a Critical Regulator of Bone Homeostasis Via Modulation of c-Fos Levels in Osteoclasts.	DGKZ PLCG2	5.68e-05	3	152	2	25891971
Pubmed	Calcium/calmodulin kinase II-dependent acetylcholine receptor cycling at the mammalian neuromuscular junction in vivo.	CAMK2D CAMK2G	5.68e-05	3	152	2	20844140
Pubmed	Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis.	CHST5 CHST4	5.68e-05	3	152	2	12855678
Pubmed	Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy.	CAMK2D CAMK2G	5.68e-05	3	152	2	25489064
Pubmed	CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia.	CAMK2D CAMK2G	5.68e-05	3	152	2	33926209
Pubmed	Phosphorylation of Serine 235 of the Hepatitis C Virus Non-Structural Protein NS5A by Multiple Kinases.	CAMK2D CAMK2G	5.68e-05	3	152	2	27875595
Pubmed	Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue.	CHST5 CHST4	5.68e-05	3	152	2	10491328
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	PDS5B OGT EP400 CAMK2D POLRMT SMC4 CHD8 XPC POP1	6.34e-05	394	152	9	27248496
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	CAD OGT SLC26A2 MTHFD2 CAMK2G SREBF1 PFAS CHD8 SPG11 POLA2 DIPK2A KHSRP PAPOLG DIMT1 INTS2 TAS1R1 LSS	7.43e-05	1327	152	17	32694731
Pubmed	Functional genomics identifies therapeutic targets for MYC-driven cancer.	CAMK2D CAMK2G SPEG HPS1 TRIB1	9.26e-05	103	152	5	22623531
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PDS5B CAD ERCC3 EP400 CAMK2D CAMK2G POLRMT SMC4 PFAS CHD8 XPC KHSRP DIMT1 POP1 PRR14L PLCG2 ALOX12B	9.40e-05	1353	152	17	29467282
Pubmed	Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression.	ABCA3 SREBF1	1.13e-04	4	152	2	17890326
Pubmed	Early-onset L-dopa-responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations.	SPG11 ATP13A2	1.13e-04	4	152	2	20669327
Pubmed	Developmental expression of the CaM kinase II isoforms: ubiquitous gamma- and delta-CaM kinase II are the early isoforms and most abundant in the developing nervous system.	CAMK2D CAMK2G	1.13e-04	4	152	2	10381553
Pubmed	Role of the F-box protein Skp2 in cell proliferation in the developing auditory system in mice.	MYO7A SKP2	1.13e-04	4	152	2	12692478
Pubmed	Impaired type I IFN-induced Jak/STAT signaling in FA-C cells and abnormal CD4+ Th cell subsets in Fancc-/- mice.	FANCC TYK2	1.13e-04	4	152	2	15356134
Pubmed	Structural imaging in the presymptomatic stage of genetically determined parkinsonism.	LRRK2 ATP13A2	1.13e-04	4	152	2	20483373
Pubmed	The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA.	ERCC3 XPC	1.13e-04	4	152	2	10734143
Pubmed	CD21 and FCRL5 form a receptor complex with robust B-cell activating capacity.	PLCG2 FCRL5	1.13e-04	4	152	2	30107486
Pubmed	DNA nucleotide excision repair-dependent signaling to checkpoint activation.	ERCC3 XPC	1.13e-04	4	152	2	17088560
Pubmed	Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells.	CAMK2D CAMK2G	1.13e-04	4	152	2	17367784
Pubmed	Tat-dependent occlusion of the HIV poly(A) site.	PAPOLG PAPOLA	1.13e-04	4	152	2	8491200
Pubmed	[Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions].	CAMK2D CAMK2G	1.13e-04	4	152	2	11889801
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	EXOSC9 CAD ERCC3 EP400 POLRMT CHD8 MAP3K4 LRCH3 POP1	1.46e-04	440	152	9	34244565
Pubmed	Proteomic profiling of Myc-associated proteins.	PDS5B EP400 CAMK2D SPEG SMC4	1.49e-04	114	152	5	21150319
Pubmed	The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.	INTS3 INTS10 INTS2	1.75e-04	25	152	3	34004147
Pubmed	Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding protein.	CAMK2D CAMK2G	1.88e-04	5	152	2	11013247
Pubmed	Alpha-kinase anchoring protein alphaKAP interacts with SERCA2A to spatially position Ca2+/calmodulin-dependent protein kinase II and modulate phospholamban phosphorylation.	CAMK2D CAMK2G	1.88e-04	5	152	2	19671701
Pubmed	Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.	CAMK2D CAMK2G	1.88e-04	5	152	2	21209221
Pubmed	Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II.	CAMK2D CAMK2G	1.88e-04	5	152	2	14722083
Pubmed	Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.	ARHGEF11 PLXNB1	1.88e-04	5	152	2	12183458
Pubmed	Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags.	LRRK2 SIRPB1	1.88e-04	5	152	2	12213963
Pubmed	Abnormal vesicular trafficking in mouse models of Hermansky-Pudlak syndrome.	HPS1 RABGGTA	1.88e-04	5	152	2	11041359
Pubmed	Characterization of the P5 subfamily of P-type transport ATPases in mice.	ATP13A5 ATP13A2	1.88e-04	5	152	2	15381061
Pubmed	Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure.	CAMK2D CAMK2G	1.88e-04	5	152	2	18218981
Pubmed	FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis.	FAM86B1 FAM86B2	1.88e-04	5	152	2	38508183
Pubmed	Parkinson disease related ATP13A2 evolved early in animal evolution.	ATP13A5 ATP13A2	1.88e-04	5	152	2	29505581
Pubmed	GlcNAc6ST3 is a keratan sulfate sulfotransferase for the protein-tyrosine phosphatase PTPRZ in the adult brain.	CHST5 CHST4	1.88e-04	5	152	2	30867513
Pubmed	Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B.	CAMK2D CAMK2G	1.88e-04	5	152	2	16436603
Pubmed	MEKK4 is an effector of the embryonic TRAF4 for JNK activation.	MAP3K4 TRAF4	1.88e-04	5	152	2	16157600
Pubmed	Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F.	MYO7A CAMK2G	1.88e-04	5	152	2	11398101
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	PDS5B EXOSC9 EP400 SMC4 OBSL1 CHD8 POLA2 INTS3 INTS2	2.34e-04	469	152	9	27634302
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	EARS2 RNF19B GPS1 TTC14 POR PFAS NUFIP1 ZBTB7A FGD5 ALOX12B NOL8	2.37e-04	689	152	11	36543142
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	EXOSC9 EP400 CHD8 ALKBH5 KHSRP PAPOLA NOL8	2.60e-04	283	152	7	30585729
Pubmed	Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2.	CAMK2D CAMK2G	2.81e-04	6	152	2	16120608
Pubmed	Multiple kinases regulate mafA expression in the pancreatic beta cell line MIN6.	CAMK2D CAMK2G	2.81e-04	6	152	2	18948074
Pubmed	A novel motif in the Crohn's disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses.	MAP3K4 TRAF4	2.81e-04	6	152	2	21097508
Pubmed	Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.	CAMK2D CAMK2G	2.81e-04	6	152	2	11972023
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	OGT CAMK2D TTC14 DGKZ LCMT2 PAPOLA INTS2 DDHD1 SBF2 HPS1 POP1 PAN2 NLRP4 PLXNB1	3.04e-04	1084	152	14	11544199
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	EXOSC9 CAD PRTN3 MYO7A OBSL1 LRCH3 DIMT1 POP1 RASGEF1C	3.52e-04	496	152	9	31343991
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	SLC26A2 OBSL1 NCKAP5L DIPK2A FAM20C TRAF4 EIF3C	3.84e-04	302	152	7	30561431
Pubmed	ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion.	CAMK2D CAMK2G	3.93e-04	7	152	2	34932950
Pubmed	Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.	CHD8 ZBTB7A	3.93e-04	7	152	2	26816381
Pubmed	Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.	TRIB1 ALOX12B	3.93e-04	7	152	2	10727209
Pubmed	IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling.	MAP3K4 TRAF4	3.93e-04	7	152	2	22547678
Pubmed	Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II.	CAMK2D CAMK2G	3.93e-04	7	152	2	9115241
Pubmed	A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy.	ERCC3 XPC	3.93e-04	7	152	2	10447254
Pubmed	Interaction with ectopic cochlear crista sensory epithelium disrupts basal cochlear sensory epithelium development in Lmx1a mutant mice.	MYO7A CLCN1	3.93e-04	7	152	2	31932950
Pubmed	Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family.	CHST5 CHST4	3.93e-04	7	152	2	11181564
Pubmed	Putative tyrosine kinases expressed in K-562 human leukemia cells.	RYK TYK2	3.93e-04	7	152	2	2247464
Cytoband	19p13.3	PRTN3 PLK5 POLRMT TPGS1 KHSRP ZBTB7A ANGPTL4	1.60e-05	237	153	7	19p13.3
GeneFamily	Integrator complex	INTS3 INTS10 INTS2	6.91e-05	15	99	3	1366
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	MYO7A PTPN21 FRMD4B TYK2	1.61e-04	50	99	4	1293
GeneFamily	Parkinson disease associated genes\|ATPase orphan transporters	ATP13A5 ATP13A2	2.94e-04	5	99	2	1213
GeneFamily	WD repeat domain containing\|Xeroderma pigmentosum complementation groups\|Nucleotide excision repair	ERCC3 XPC	8.13e-04	8	99	2	1125
GeneFamily	VPS9 domain containing	ALS2CL VPS9D1	1.30e-03	10	99	2	928
GeneFamily	ATP binding cassette subfamily A	ABCA3 ABCA13	2.59e-03	14	99	2	805
GeneFamily	Parkinson disease associated genes	LRRK2 ATP13A2	3.39e-03	16	99	2	672
Coexpression	LIU_SOX4_TARGETS_DN	EP400 DGKZ SKP2 MAP3K4 TRAF4 DIMT1 MOCS3 CBFA2T2 HPS1 EIF3C ZNF654	2.09e-06	310	152	11	M17287
Coexpression	GSE46606_IRF4MID_VS_WT_CD40L_IL2_IL5_DAY3_STIMULATED_BCELL_DN	CIB1 FPR1 TTC14 TPGS1 DGKZ XPC SIRPB1 ATP13A2	2.29e-05	200	152	8	M9859
Coexpression	GSE22140_HEALTHY_VS_ARTHRITIC_GERMFREE_MOUSE_CD4_TCELL_UP	OGT POLRMT PEX7 DGKZ RYK CBFA2T2 PLCG2 RABGGTA	2.29e-05	200	152	8	M7648
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTLL5 NAA80 DTD2 FAM20C SNX25 DDHD1 TRIB1 PLXNB1	2.12e-07	180	153	8	be10fe5bf7c3a671c42704ce7dd8226ab6896794
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTLL5 NAA80 DTD2 FAM20C SNX25 DDHD1 TRIB1 PLXNB1	2.12e-07	180	153	8	3b747a517ce75ef2ff09011c037dad7b01ed3e03
ToppCell	COVID-19_Convalescent-PLT_1\|World / Disease Group and Platelet Clusters	ZNF449 ZNF142 PLCXD1 CDKL3 INTS3 FAM187B RABGGTA	2.92e-06	179	153	7	d0f2764c6fc5d61fd69e9231b3603a80ac373f65
ToppCell	AT2_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	ABCA3 RARRES2 PLCXD1 LRRK2 GABBR2 SNX25 ANGPTL4	3.62e-06	185	153	7	3b3268e3f99121124e33086cac88479808d31630
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-stromal_related-FDC\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA3 RARRES2 ACHE GABBR2 PTPRM NPB CHST4	4.95e-06	194	153	7	f9fbb043411546d8c9e0321a64165d411f44aeb7
ToppCell	cellseq2-Epithelial-Epithelial_Alveolar-AT2-AT2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCA3 EARS2 LRRK2 SMC4 LYSMD1 FAM20C SNX25	4.95e-06	194	153	7	df835578d86a49ae5af5632152fbab9548c0a448
ToppCell	cellseq2-Epithelial-Epithelial_Alveolar\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCA3 EARS2 LRRK2 SMC4 LYSMD1 FAM20C SNX25	4.95e-06	194	153	7	0715f2d55f4a6d2edda1b3dc52f12d25ce59eb10
ToppCell	cellseq2-Epithelial-Epithelial_Alveolar-AT2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCA3 EARS2 LRRK2 SMC4 LYSMD1 FAM20C SNX25	4.95e-06	194	153	7	a4f7cd507eba40985d82635bbae28c7f5703f883
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	ABCA3 PLCXD1 LRRK2 OBSL1 ANGPTL4 KANK4 PLXNB1	5.48e-06	197	153	7	1a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / Treatment groups by lineage, cell group, cell type	ABCA3 PLCXD1 LRRK2 OBSL1 ANGPTL4 KANK4 PLXNB1	5.66e-06	198	153	7	d087e738d69ca9853553fde46d4e7a8906439d32
ToppCell	LPS_only-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets\|LPS_only / Treatment groups by lineage, cell group, cell type	POLA2 SKP2 ALKBH5 INTS10 HPS1 SEL1L3	8.32e-06	138	153	6	6ddd50e44a3914596b4cd61ae64a987119fe7979
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF449 ABCA3 LRRK2 ANKRD23 DTD2 RNF207	3.30e-05	176	153	6	33323c97afe509147956b8df9f92ca6b0537e604
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_C\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ABCA3 THNSL1 SPEG CHD8 PAPOLG MOCS3	3.51e-05	178	153	6	50bb1f2c6a8d050ff2af217fd76c3b1b7b4a4a69
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL7A1 RARRES2 ACHE SPEG DIPK2A ANGPTL4	3.63e-05	179	153	6	f5bb4d3a27d56698473219970e764084096cc582
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL7A1 RARRES2 ACHE SPEG DIPK2A ANGPTL4	3.63e-05	179	153	6	fa03ec3cc0132f977b4cb28e7b23789732375183
ToppCell	18-Airway-Epithelial-Submucosal_gland_basal\|Airway / Age, Tissue, Lineage and Cell class	COL7A1 DOK7 CYP4X1 TRIB1 RASAL1 GASK1A	3.86e-05	181	153	6	33938e6521712058312879f84f4ae381c2bfc379
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST5 COL7A1 RARRES2 DIPK2A ANGPTL4 PLXNB1	3.98e-05	182	153	6	9edaccf1154cec92ca9a28e9b1f9075cfd422bfd
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA13 LRRK2 FANCC ASB18 SEL1L3 PDZRN3	3.98e-05	182	153	6	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST5 COL7A1 RARRES2 DIPK2A ANGPTL4 PLXNB1	3.98e-05	182	153	6	aba4c06d5d7618ac21b2695bca8e7a1346a91090
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHST5 COL7A1 RARRES2 ACHE DIPK2A PLXNB1	4.23e-05	184	153	6	4cb5f299dd7413e0be1ad7af817ee614b23a18ae
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-pericyte_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHST5 COL7A1 RARRES2 ACHE DIPK2A PLXNB1	4.23e-05	184	153	6	39bb0eb55bdc2cea46e41c7f21d8c5883f14e6bd
ToppCell	IPF-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	ABCA3 PLCXD1 LRRK2 TEX14 FRMD4B SNX25	4.77e-05	188	153	6	5f5fad2773e421760e67dbace23fd1f847a2e1e0
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO7A FPR1 LRRK2 SIRPB1 RASGEF1C RASAL1	4.91e-05	189	153	6	b8cbfc47f3f40b6fccd15899d58c87d07b0001aa
ToppCell	PBMC-Severe-Myeloid-Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PRTN3 ABCA13 FPR1 LRRK2 PLCG2 TRIB1	5.05e-05	190	153	6	cb62ece5929896dfba30a4f563c6ba5a5712b71e
ToppCell	PBMC-Severe-Myeloid-Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PRTN3 ABCA13 FPR1 LRRK2 PLCG2 TRIB1	5.05e-05	190	153	6	fedd266198d294d8da8c9e217e5e0cb8b2e1b566
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	OGT TTC14 MAP3K4 OPRD1 LRCH3 PLCG2	5.51e-05	193	153	6	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	COVID-19_Mild-Lymphoid_B-B_intermediate\|COVID-19_Mild / Disease group, lineage and cell class	GALNTL6 TRAF4 SNX25 SEL1L3 PLCG2 FCRL5	5.67e-05	194	153	6	bf6f72a489c62cbf1a679552d8c5eaaaa0b99d33
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-6\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CIB1 DOK7 TRAF4 SEL1L3 PLCG2 FCRL5	5.67e-05	194	153	6	2b5eee7c3e52b63cce94205d18133c7704329c02
ToppCell	Control_saline-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	ABCA3 PLCXD1 LRRK2 TTC14 OBSL1 TRIB1	6.18e-05	197	153	6	44a59dfb889577b3160a5b13ada1276771a00241
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ABCA3 PLCXD1 LRRK2 OBSL1 KANK4 PLXNB1	6.18e-05	197	153	6	1485933986921ff45669d9b7501c8d17050b3e97
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ABCA3 PLCXD1 LRRK2 OBSL1 KANK4 PLXNB1	6.35e-05	198	153	6	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	Severe-B_intermediate-10\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	GALNTL6 CIB1 CAMK2D LRRK2 FAM20C FCRL5	6.35e-05	198	153	6	dfae26c3513a82bb7cb8dadbfcea2a1f420b1bab
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / Treatment groups by lineage, cell group, cell type	ABCA3 LRRK2 OBSL1 ANGPTL4 KANK4 PLXNB1	6.35e-05	198	153	6	655df75b9692d815c7f6910275e1f684ac63bf62
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-B-B_intermediate\|COVID-19_Mild / Disease, condition lineage and cell class	GALNTL6 TRAF4 SNX25 SEL1L3 PLCG2 FCRL5	6.53e-05	199	153	6	1c6a08d01f6c1a2a4b6587d3a4522efbd03275e1
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-1m-Mesenchymal-Mesoderm\|1m / Sample Type, Dataset, Time_group, and Cell type.	ACHE LYSMD1 TEX14 SLC29A2 ALKBH5 RNF207	6.71e-05	200	153	6	c0ad32e9dd7f481c2665587fd8bd9fffc2e725f9
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ZSWIM5 PEX7 LYSMD1 KANK4 RNF207 PLXNB1	6.71e-05	200	153	6	5ad3ea1cf1fcd4100966c5517bc7ed0a1af54317
ToppCell	mild-B_intermediate\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GALNTL6 TRAF4 SNX25 SEL1L3 PLCG2 FCRL5	6.71e-05	200	153	6	fe815824e9e4be3f3db73610e3814a7fd533da65
ToppCell	mild-B_intermediate\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GALNTL6 TRAF4 SNX25 SEL1L3 PLCG2 FCRL5	6.71e-05	200	153	6	8e3132a1fe3708f725c5c4077878fb87bbea3678
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ZSWIM5 LYSMD1 KANK4 CYP4X1 RNF207 PLXNB1	6.71e-05	200	153	6	be46efc899d06c55ee297bee3126f69bcdb2048b
ToppCell	Sigmoid-T_cell-Tfh\|T_cell / Region, Cell class and subclass	MTHFD2 CDKL3 SKP2 BOLA2 DYNLT4 FDXACB1	6.71e-05	200	153	6	dd7dcf25520f065bf0d33d589f3c176f63875dc9
Disease	resting heart rate	ACHE SPEG SREBF1 FRMD4B FMNL3 RNF207	8.72e-05	149	142	6	EFO_0004351
Disease	juvenile-onset Parkinson's disease (implicated_via_orthology)	ATP13A5 ATP13A2	1.37e-04	4	142	2	DOID:0060893 (implicated_via_orthology)
Disease	Kufor-Rakeb syndrome (implicated_via_orthology)	ATP13A5 ATP13A2	1.37e-04	4	142	2	DOID:0060556 (implicated_via_orthology)
Disease	treprostinil dose measurement	CAMK2D PFAS	2.28e-04	5	142	2	EFO_0021489
Disease	rheumatoid arthritis, ACPA-negative rheumatoid arthritis	ANKRD55 TYK2	2.28e-04	5	142	2	EFO_0000685, EFO_0009460
Disease	xeroderma pigmentosum (is_implicated_in)	ERCC3 XPC	3.41e-04	6	142	2	DOID:0050427 (is_implicated_in)
Disease	xeroderma pigmentosum (implicated_via_orthology)	ERCC3 XPC	3.41e-04	6	142	2	DOID:0050427 (implicated_via_orthology)
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	ATP13A5 ALS2CL ATP13A2	4.03e-04	30	142	3	DOID:332 (implicated_via_orthology)
Disease	Ovarian Mucinous Adenocarcinoma	SPEG LRRK2 RYK	4.44e-04	31	142	3	C1335167
Disease	heart conduction disease (implicated_via_orthology)	CAMK2D CAMK2G SREBF1	4.89e-04	32	142	3	DOID:10273 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	COL7A1 ABCA3 ERCC3 ZSWIM5 ACHE ALS2CL MOSPD1 CLCN1 OTOF ANGPTL4 POP1 FGD5 FCRL5 PLXNB1	7.01e-04	1074	142	14	C0006142
Disease	Xeroderma pigmentosum	ERCC3 XPC	8.10e-04	9	142	2	cv:C0043346
Disease	free cholesterol measurement, high density lipoprotein cholesterol measurement	OBSL1 INTS10 SBF2 ANGPTL4 KANK4 TRIB1 RABGGTA	8.61e-04	315	142	7	EFO_0004612, EFO_0008591
Disease	phospholipid measurement, high density lipoprotein cholesterol measurement	COL7A1 OBSL1 INTS10 SBF2 ANGPTL4 TRIB1 RABGGTA	9.60e-04	321	142	7	EFO_0004612, EFO_0004639
Disease	Basal cell carcinoma	ERCC3 XPC	1.23e-03	11	142	2	C0007117
Disease	Tremor	ZNF142 ACHE	1.23e-03	11	142	2	C0040822
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	SPG11 INTS10 ANGPTL4 TRIB1	1.57e-03	103	142	4	EFO_0008595, EFO_0020944
Disease	ocular hypertension, response to triamcinolone acetonide	IL17RC TEX14 ANGPTL4	1.71e-03	49	142	3	EFO_0006954, EFO_1001069
Disease	hepatocellular carcinoma (biomarker_via_orthology)	CAD MTHFD2 PFAS SKP2	1.87e-03	108	142	4	DOID:684 (biomarker_via_orthology)
Disease	coronary artery disease	SETD9 PDS5B DOK7 SREBF1 HSF2BP SKP2 ALS2CL ANKRD55 ANGPTL4 PAN2 FGD5 PLCG2 NLRP4 TRIB1	1.91e-03	1194	142	14	EFO_0001645
Disease	polyunsaturated fatty acids to monounsaturated fatty acids ratio	INTS10 ANGPTL4 TRIB1	1.92e-03	51	142	3	EFO_0022302
Disease	neuronal ceroid lipofuscinosis (implicated_via_orthology)	ATP13A5 ATP13A2	2.01e-03	14	142	2	DOID:14503 (implicated_via_orthology)
Disease	T wave morphology measurement	CAMK2D RNF207	2.01e-03	14	142	2	EFO_0008398
Disease	triglycerides in medium VLDL measurement	INTS10 ANGPTL4 TRIB1	2.38e-03	55	142	3	EFO_0022155
Disease	cholesterol to total lipids in large HDL percentage	INTS10 ANGPTL4 TRIB1	2.38e-03	55	142	3	EFO_0022234
Disease	triglycerides in large VLDL measurement	INTS10 ANGPTL4 TRIB1	2.51e-03	56	142	3	EFO_0022178
Disease	triglycerides in very large VLDL measurement	INTS10 ANGPTL4 TRIB1	2.51e-03	56	142	3	EFO_0022325
Disease	triglycerides to total lipids in medium HDL percentage	INTS10 ANGPTL4 TRIB1	2.51e-03	56	142	3	EFO_0022333
Disease	cholesteryl esters to total lipids in medium HDL percentage	INTS10 ANGPTL4 TRIB1	2.51e-03	56	142	3	EFO_0022251
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	SPG11 INTS10 ANGPTL4 TRIB1	2.83e-03	121	142	4	EFO_0008595, EFO_0020943
Disease	triglycerides in VLDL measurement	INTS10 ANGPTL4 TRIB1	2.91e-03	59	142	3	EFO_0022326
Disease	diabetic neuropathy (biomarker_via_orthology)	LRRK2 SREBF1	2.98e-03	17	142	2	DOID:9743 (biomarker_via_orthology)
Disease	triglycerides to total lipids in large HDL percentage	INTS10 ANGPTL4 TRIB1	3.06e-03	60	142	3	EFO_0022330
Disease	total lipids in VLDL measurement	INTS10 ANGPTL4 TRIB1	3.06e-03	60	142	3	EFO_0022314
Disease	cholesterol to total lipids in medium HDL percentage	INTS10 ANGPTL4 TRIB1	3.06e-03	60	142	3	EFO_0022237
Disease	triglycerides in small VLDL measurement	INTS10 ANGPTL4 TRIB1	3.20e-03	61	142	3	EFO_0022145
Disease	free cholesterol in very large VLDL measurement	INTS10 ANGPTL4 TRIB1	3.20e-03	61	142	3	EFO_0022274
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	SPG11 ANGPTL4 TRIB1	3.20e-03	61	142	3	EFO_0008317, EFO_0008596, EFO_0020946
Disease	triglycerides in small HDL measurement	INTS10 ANGPTL4 TRIB1	3.35e-03	62	142	3	EFO_0022158
Disease	phospholipids in large VLDL measurement	INTS10 ANGPTL4 TRIB1	3.35e-03	62	142	3	EFO_0022169
Disease	triglycerides to total lipids in very large HDL percentage	INTS10 ANGPTL4 TRIB1	3.35e-03	62	142	3	EFO_0022339
Disease	total lipids in very large VLDL measurement	INTS10 ANGPTL4 TRIB1	3.35e-03	62	142	3	EFO_0022313
Disease	phospholipids in very large VLDL measurement	INTS10 ANGPTL4 TRIB1	3.35e-03	62	142	3	EFO_0022299
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	SPG11 INTS10 ANGPTL4 TRIB1	3.36e-03	127	142	4	EFO_0008595, EFO_0020947
Disease	neck circumference	GALNTL6 PDZRN3	3.73e-03	19	142	2	EFO_0011043
Disease	cholesterol in large VLDL measurement	INTS10 ANGPTL4 TRIB1	3.83e-03	65	142	3	EFO_0021902
Disease	cholesterol in very large VLDL measurement	INTS10 ANGPTL4 TRIB1	3.83e-03	65	142	3	EFO_0022230
Disease	acetate measurement	SPG11 TRIB1	4.13e-03	20	142	2	EFO_0010112
Disease	total lipids in large VLDL	INTS10 ANGPTL4 TRIB1	4.17e-03	67	142	3	EFO_0022175
Disease	cholesterol to total lipids in very small VLDL percentage	INTS10 ANGPTL4 TRIB1	4.17e-03	67	142	3	EFO_0022245
Disease	triglycerides to phosphoglycerides ratio	INTS10 ANGPTL4 TRIB1	4.35e-03	68	142	3	EFO_0022327
Disease	free cholesterol in large VLDL measurement	INTS10 ANGPTL4 TRIB1	4.35e-03	68	142	3	EFO_0022265

Protein segments in the cluster

Peptide	Gene	Start	Entry
VACLRTRPAQVLVNH	ACHE	301	P22303
LRDVLCTPAHRLLQD	ALS2CL	221	Q60I27
LVRLQRICNHPGLVE	EP400	1361	Q96L91
LVDFVRQHRIPLELC	ADAL	246	Q6DHV7
QCVPHLIREGRAALV	ATP13A5	886	Q4VNC0
ELLRRLREQVLCHPL	CHD8	1891	Q9HCK8
LREQVLCHPLLEDRL	CHD8	1896	Q9HCK8
LHRLPRDCQELFQVG	ANGPTL4	181	Q9BY76
VAVRTRHPDCLEHLI	ANKRD23	216	Q86SG2
HCIRPQDIKERRAVI	ALKBH5	266	Q6P6C2
DIVHACLQIDPADRI	CDKL3	261	Q8IVW4
AELQFPVSHLERCLR	H2AL3	21	A0A3B3IU63
ESHPQCRRLQLRDLI	ARHGEF11	861	O15085
IPERHIGACVENTLR	ABCA3	1486	Q99758
QCIPEVAGDLIRRLH	ABCA13	4831	Q86UQ4
QRHRLVNACLAEELP	BOLA2	51	Q9H3K6
VPACRLVHRRQLTEA	DEPDC1B	166	Q8WUY9
IIHELARVPECNLQA	ANKRD55	246	Q3KP44
LVREALQLCRPAVEL	NWD1	786	Q149M9
RCHVLQARDLAPRDI	RASAL1	136	O95294
RVVKLQQLPEHLERC	PDZRN3	91	Q9UPQ7
RFNDIHVPIRLECVK	PDS5B	321	Q9NTI5
LGRLVHCPIETQVLR	RARRES2	111	Q99969
EHPEALSCLLLQLRR	INTS3	836	Q68E01
CDVLPLIINNHDVRL	INTS10	176	Q9NVR2
EITILRECRHPNVVA	MAP4K2	61	Q12851
LHAEGPRRVLCIQAA	OBSL1	1221	O75147
TRNIRHLPDILVINC	PAN2	731	Q504Q3
QCLHARLQIRPADGD	DTD2	16	Q96FN9
LLRDILQKTVRHPVC	FAM86B2	46	P0C5J1
RNRLSEIPIEACHFV	LRCH3	91	Q96II8
ACSPVRERRLEHQLE	LYSMD1	31	Q96S90
VEARRHILAILQDCP	POR	421	P16435
EPGTCQELLHRLREL	NCKAP5L	26	Q9HCH0
RSCLQLIRIHAEPVI	SBF2	371	Q86WG5
HRRPELLDACADLIN	NAA80	66	Q93015
ELCEQVHVRLRELSP	DYNLT4	151	Q5JR98
ACVRLLLQHRADPDL	ASB18	166	Q6ZVZ8
LLRDILQKTVRHPVC	FAM86B1	46	Q8N7N1
IAAIVALCHFRRPDV	EXOSC9	151	Q06265
NLPLLQRELLHCARA	CBFA2T2	181	O43439
RLEDIRVVVGDQPCH	PLXNB1	1191	O43157
PRAQAVVGDLLELHC	FCRL5	666	Q96RD9
RIVIPAHQAEILSCD	PEX7	191	O00628
RIERLQFIADHCPTL	GPS1	56	Q13098
ENCLHSPRLAAAVRE	FGD5	1006	Q6ZNL6
DPLIVLRCDQRVHRC	INTS2	856	Q9H0H0
EHIPRERLCDAVAVL	LSS	476	P48449
PQCCVDIVIRHRDVR	MOSPD1	71	Q9UJG1
PEVEAALRHLQLCLD	PLK5	171	Q496M5
LGDCDIPIIQRISHV	KIF24	181	Q5T7B8
DSRILCLALVHLPVE	LRRK2	2196	Q5S007
LCEALRHPECALQVL	NLRP4	941	Q96MN2
ALEHARDVVCALLPR	MROH6	181	A6NGR9
HLRCAEFELRLTDPV	PLCG2	621	P16885
RQCIRPAEIVASLLE	NOL8	536	Q76FK4
VLTAAHCLRDIPQRL	PRTN3	66	P24158
HCLRDIPQRLVNVVL	PRTN3	71	P24158
LLADLHPSVRQRCLI	GPR78	216	Q96P69
TDIRIGDIHLRDNCP	OOSP4B	31	A0A2R8Y4Y8
GDIHLRDNCPVTRLL	OOSP4B	36	A0A2R8Y4Y8
LERHPREVVILACRN	PLCXD1	141	Q9NUJ7
RRDPLVVAALHLCIA	OPRD1	291	P41143
ACLEHNEVLDIPRVL	PTPN21	1126	Q16825
LNGCRVTDEILHLVP	PAPOLA	201	P51003
VRQLLLEGVPVECTH	POP1	536	Q99575
ADIDALCVAPRHVER	PAPOLG	111	Q9BWT3
LHNADQPLRVRGCIL	EIF3C	431	Q99613
REKCQNPAELRLVHI	GASK1A	456	Q9UFP1
CQVHLLDDRRLELLV	FRMD4B	61	Q9Y2L6
RLRPCNLAHAETLVI	ATP13A2	76	Q9NQ11
CALHIALDLLPRLER	FAM20C	21	Q8IXL6
DLVHCPSQRLLDRLV	DIPK2A	166	Q8NDZ4
QRRCHLEPNVRGLES	FMNL3	466	Q8IVF7
PEHQERCREEVRGIL	CYP4X1	336	Q8N118
EALLICHGREPQEIL	FANCC	201	Q00597
LLQRIHEEESAVVCP	GALNT12	241	Q8IXK2
QCPQDLGELIIIRLH	ALOX12B	56	O75342
GRDISIRPLLEHCEN	GABBR2	636	O75899
NVDLVRLLLAHPACD	KANK4	941	Q5T7N3
CAGILAEAPRVRAQH	COL7A1	11	Q02388
RLRPELQVEACHVQC	FAM187B	191	Q17R55
SQDHILPREICNRLL	DDHD1	641	Q8NEL9
QHLLQDPVIRECRLR	ERCC3	186	P19447
LCRAHIERLQQEPDG	DGKZ	686	Q13574
LHLCNDVLVLARDIP	DOK7	131	Q18PE1
CLRPSLLVHVQDVIE	FDXACB1	346	Q9BRP7
FAVEALERLIHPQLC	HPS1	166	Q92902
RNLLPITHVCIEEGE	RYK	391	P34925
VCREQFVRLHSEPIL	POLRMT	1166	O00411
EARICRLLKHPNIVR	CAMK2G	61	Q13555
HLLLDVRPQVEVDIC	MOCS3	351	O95396
VRPQVEVDICRLPHA	MOCS3	356	O95396
VVACELDPRLVAELH	DIMT1	81	Q9UNQ2
ARCVLLEVQVPAALV	IL17RC	206	Q8NAC3
EARICRLLKHPNIVR	CAMK2D	61	Q13557
ELLHPPLNIRVVDCR	OTOF	1196	Q9HC10
RALPLELQRTHVESC	PRR14L	61	Q5THK1
RVEDCSIALLPRNHE	PTPRM	1201	P28827
HVRRGQLADVCLDTP	OGT	911	O15294
VPPVLRLACADIRVH	OR10Q1	186	Q8NGQ4
VIHECLKLRLEQRPA	MAP3K4	626	Q9Y6R4
PDRCEHAARIINDLL	KHSRP	376	Q92945
IALERSLPDIRHANC	GALNTL6	116	Q49A17
DPDAEVCLHVLRLVQ	HSF2BP	266	O75031
DHRAEFARCLEPLLL	RNF207	341	Q6ZRF8
NLAHICEERPDLARR	SEL1L3	911	Q68CR1
CSERLNPHDIRLLLA	RNF19B	166	Q6ZMZ0
CLAPRQVLPHEREVA	SLC29A2	416	Q14542
PHCSRLRLADLLIAE	TEX14	281	Q8IWB6
RDFICVNILERGLHP	TBC1D21	46	Q8IYX1
VQLPLPEHIDERRIC	MTHFD2	131	P13995
LIELCPELRVHLDQL	SNX25	821	Q9H3E2
LGRADPQDALRCLHV	RABGGTA	236	Q92696
IALIALDRCVCVLHP	FPR1	116	P21462
SPLRCVVLVALRDIN	SETD9	271	Q8NE22
AHRDINVPRALVDIL	SHISA7	216	A6NL88
LDLIAVINHDRPDVC	POLA2	361	Q14181
LVGLAVCNTPHERLR	NDUFA5	11	Q16718
LHPRLRSLAVCVQDV	NPB	76	Q8NG41
GQEEALRLHALCRVL	RHPN1	416	Q8TCX5
RQGHICRLQDLVSPV	EARS2	406	Q5JPH6
ICEVAHVTLQGDPLR	SIRPB1	226	Q5TFQ8
REHLLERALNCVTQP	SREBF1	806	P36956
RLCPLVEHLPRVLQE	SREBF1	896	P36956
EILLAHRRFCELLPQ	CIB1	26	Q99828
IPQDEIIPRAHCRLL	CHST4	141	Q8NCG5
EADPHLRLIREVCRS	CHST5	256	Q9GZS9
AVRHQLVLDCPREAA	LINC01465	6	Q8N7H1
ELQALLQRHLCPERR	CLCN1	656	P35523
ICEIAHITLQGDPLR	SIRPB1	226	O00241
DLSTLVRRCPNLVHL	SKP2	301	Q13309
CVILHIIFPERDAAI	SPG11	171	Q96JI7
VARVHALEQAPILCR	nan	116	Q8NFD4
LEHVPTACARVDALR	ZSWIM5	536	Q9P217
LLPLAEREHVSRALC	TRIB1	96	Q96RU8
LQVRHRPEVTLCDRS	TAS1R1	51	Q7RTX1
PDIRHERNVILQCVR	NUFIP1	461	Q9UHK0
RQCEARLEVRAHPES	SPEG	951	Q15772
DQCRPYHRILIERQE	SLC26A2	46	P50443
RLFIEPRELLARVCH	RASGEF1C	71	Q8N431
PRELLARVCHLCIEQ	RASGEF1C	76	Q8N431
VHQALERVLRLPAVA	PFAS	661	O15067
DFEARQLLRVLPCNH	RNF44	386	Q7L0R7
AHFLPNDLEILRICA	ZNF654	381	Q8IZM8
PIKVLCRRVEILNEH	SMC4	266	Q9NTJ3
RAQILLERCIHPADI	THNSL1	291	Q8IYQ7
IAHLEITALCPLRDV	TTC14	156	Q96N46
ELEVQVLGLPIRCIH	TRAF4	71	Q9BUZ4
VELAAKHCRRPVINA	CAD	2031	P27708
IQHCPASREREVRAV	PRR29	146	P0C7W0
ERALRTHQIRGCPLE	ZNF142	1116	P52746
DHPIAQLLRRLQCSV	VPS9D1	281	Q9Y2B5
HCFLPAEERRRVENI	LCMT2	276	O60294
LPNLHRVARKLDIDC	XPC	776	Q01831
VAPLLRKVQCRDHEA	TPGS1	161	Q6ZTW0
REHCPENRERVVSLI	ZNF449	91	Q6P9G9
CRRIPVLVFHADAIL	TTLL5	36	Q6EMB2
ARLLEIPAVSHVCAD	ZBTB7A	111	O95365
LICHIVQELPRILGD	ULK4	806	Q96C45
GTERVPVCHLRLLAQ	TYK2	271	P29597
RKHCPLAIDCLQRLQ	MYO7A	1861	Q13402