Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	ATPase complex	CHD5 ATP6V0A4 TCIRG1 CHD3	2.18e-04	129	48	4	GO:1904949
GeneOntologyCellularComponent	vacuolar proton-transporting V-type ATPase, V0 domain	ATP6V0A4 TCIRG1	2.30e-04	10	48	2	GO:0000220
GeneOntologyCellularComponent	proton-transporting V-type ATPase, V0 domain	ATP6V0A4 TCIRG1	3.36e-04	12	48	2	GO:0033179
GeneOntologyCellularComponent	NuRD complex	CHD5 CHD3	6.87e-04	17	48	2	GO:0016581
GeneOntologyCellularComponent	CHD-type complex	CHD5 CHD3	6.87e-04	17	48	2	GO:0090545
GeneOntologyCellularComponent	vacuolar proton-transporting V-type ATPase complex	ATP6V0A4 TCIRG1	1.62e-03	26	48	2	GO:0016471
GeneOntologyCellularComponent	proton-transporting two-sector ATPase complex, proton-transporting domain	ATP6V0A4 TCIRG1	1.62e-03	26	48	2	GO:0033177
GeneOntologyCellularComponent	proton-transporting V-type ATPase complex	ATP6V0A4 TCIRG1	2.01e-03	29	48	2	GO:0033176
Domain	CHDCT2	CHD5 CHD3	1.86e-05	3	47	2	PF08074
Domain	CHDNT	CHD5 CHD3	1.86e-05	3	47	2	PF08073
Domain	DUF1086	CHD5 CHD3	1.86e-05	3	47	2	IPR009462
Domain	DUF1087	CHD5 CHD3	1.86e-05	3	47	2	IPR009463
Domain	DUF1087	CHD5 CHD3	1.86e-05	3	47	2	PF06465
Domain	DUF1086	CHD5 CHD3	1.86e-05	3	47	2	PF06461
Domain	DUF1087	CHD5 CHD3	1.86e-05	3	47	2	SM01147
Domain	DUF1086	CHD5 CHD3	1.86e-05	3	47	2	SM01146
Domain	CHD_N	CHD5 CHD3	1.86e-05	3	47	2	IPR012958
Domain	CHD_C2	CHD5 CHD3	1.86e-05	3	47	2	IPR012957
Domain	-	RASA4 RASA4B	1.86e-05	3	47	2	4.10.1130.10
Domain	V-type_ATPase_116kDa_su_euka	ATP6V0A4 TCIRG1	3.71e-05	4	47	2	IPR026028
Domain	V_ATPase_I	ATP6V0A4 TCIRG1	3.71e-05	4	47	2	PF01496
Domain	V-ATPase_116kDa_su	ATP6V0A4 TCIRG1	3.71e-05	4	47	2	IPR002490
Domain	BTK	RASA4 RASA4B	2.21e-04	9	47	2	SM00107
Domain	ZF_BTK	RASA4 RASA4B	2.21e-04	9	47	2	PS51113
Domain	Znf_Btk_motif	RASA4 RASA4B	2.21e-04	9	47	2	IPR001562
Domain	BTK	RASA4 RASA4B	2.21e-04	9	47	2	PF00779
Domain	-	RASA4 PIK3CG RASA4B SYT10	5.18e-04	148	47	4	2.60.40.150
Domain	RasGAP	RASA4 RASA4B	5.53e-04	14	47	2	SM00323
Domain	RasGAP_CS	RASA4 RASA4B	5.53e-04	14	47	2	IPR023152
Domain	Zinc_finger_PHD-type_CS	PHF20L1 CHD5 CHD3	5.85e-04	65	47	3	IPR019786
Domain	RAS_GTPASE_ACTIV_2	RASA4 RASA4B	6.37e-04	15	47	2	PS50018
Domain	RasGAP	RASA4 RASA4B	6.37e-04	15	47	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA4 RASA4B	6.37e-04	15	47	2	PS00509
Domain	-	RASA4 RASA4B	7.27e-04	16	47	2	1.10.506.10
Domain	C2_dom	RASA4 PIK3CG RASA4B SYT10	7.62e-04	164	47	4	IPR000008
Domain	RasGAP_dom	RASA4 RASA4B	9.24e-04	18	47	2	IPR001936
Domain	Chromo_domain	CHD5 CHD3	1.65e-03	24	47	2	IPR023780
Domain	ZF_PHD_1	PHF20L1 CHD5 CHD3	1.81e-03	96	47	3	PS01359
Domain	Chromo	CHD5 CHD3	1.94e-03	26	47	2	PF00385
Domain	CHROMO_2	CHD5 CHD3	2.25e-03	28	47	2	PS50013
Domain	CHROMO_1	CHD5 CHD3	2.25e-03	28	47	2	PS00598
Domain	SNF2_N	CHD5 CHD3	2.93e-03	32	47	2	PF00176
Domain	SNF2_N	CHD5 CHD3	2.93e-03	32	47	2	IPR000330
Domain	Chromodomain-like	CHD5 CHD3	2.93e-03	32	47	2	IPR016197
Domain	CHROMO	CHD5 CHD3	3.11e-03	33	47	2	SM00298
Domain	Chromo/shadow_dom	CHD5 CHD3	3.11e-03	33	47	2	IPR000953
Domain	DNA/RNA_helicase_DEAH_CS	CHD5 CHD3	3.50e-03	35	47	2	IPR002464
Domain	DEAH_ATP_HELICASE	CHD5 CHD3	4.11e-03	38	47	2	PS00690
Domain	C2	RASA4 RASA4B SYT10	4.37e-03	131	47	3	PF00168
Domain	C2	RASA4 RASA4B SYT10	4.95e-03	137	47	3	SM00239
Domain	C2	RASA4 RASA4B SYT10	5.46e-03	142	47	3	PS50004
Domain	Znf_FYVE_PHD	PHF20L1 CHD5 CHD3	6.01e-03	147	47	3	IPR011011
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	2.03e-06	2	50	2	11448776
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	2.03e-06	2	50	2	16041389
Pubmed	Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands.	TPST1 PLEC	2.03e-06	2	50	2	21665277
Pubmed	Vacuolar H+-ATPase d2 subunit: molecular characterization, developmental regulation, and localization to specialized proton pumps in kidney and bone.	ATP6V0A4 TCIRG1	6.07e-06	3	50	2	15800125
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	6.07e-06	3	50	2	25637021
Pubmed	The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells.	ATP6V0A4 TCIRG1	6.07e-06	3	50	2	24072707
Pubmed	Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.	RASA4 RASA4B	1.21e-05	4	50	2	21460216
Pubmed	Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.	RASA4 RASA4B	1.21e-05	4	50	2	16234249
Pubmed	Differential localization of vacuolar H+-ATPases containing a1, a2, a3, or a4 (ATP6V0A1-4) subunit isoforms along the nephron.	ATP6V0A4 TCIRG1	1.21e-05	4	50	2	17595521
Pubmed	The genes for the inter-alpha-inhibitor family share a homologous organization in human and mouse.	TYRP1 ITIH1	2.02e-05	5	50	2	1371941
Pubmed	The a subunit isoforms of vacuolar-type proton ATPase exhibit differential distribution in mouse perigastrulation embryos.	ATP6V0A4 TCIRG1	2.02e-05	5	50	2	35948619
Pubmed	a4, a unique kidney-specific isoform of mouse vacuolar H+-ATPase subunit a.	ATP6V0A4 TCIRG1	2.02e-05	5	50	2	11498539
Pubmed	Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution.	ATP6V0A4 TCIRG1	3.03e-05	6	50	2	21307348
Pubmed	The DNA sequence of human chromosome 7.	TPST1 RASA4 PIK3CG GALNTL5 RASA4B EPHA1	3.98e-05	441	50	6	12853948
Pubmed	Optic nerve compression and retinal degeneration in Tcirg1 mutant mice lacking the vacuolar-type H-ATPase a3 subunit.	ATP6V0A4 TCIRG1	4.23e-05	7	50	2	20711468
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	SART3 CHD5 CHD3 PLEC GTF3C4	4.40e-05	271	50	5	32433965
Pubmed	Identification of HYPK-interacting proteins reveals involvement of HYPK in regulating cell growth, cell cycle, unfolded protein response and cell death.	ATP6V0A4 ZNF516 CHD3	5.22e-05	50	50	3	23272104
Pubmed	Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.	RASA4 RASA4B	5.64e-05	8	50	2	10810084
Pubmed	Structure and Roles of V-type ATPases.	ATP6V0A4 TCIRG1	1.56e-04	13	50	2	32001091
Pubmed	DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.	CHD5 CHD3	2.10e-04	15	50	2	35695185
Pubmed	Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.	ATP6V0A4 TCIRG1	2.72e-04	17	50	2	33065002
Pubmed	A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.	CHD5 CHD3	2.72e-04	17	50	2	27806305
Pubmed	Animal plasma membrane energization by proton-motive V-ATPases.	ATP6V0A4 TCIRG1	3.05e-04	18	50	2	10440860
Pubmed	Introduction: V-ATPases 1992-1998.	ATP6V0A4 TCIRG1	3.05e-04	18	50	2	10340843
Pubmed	The vacuolar H+-ATPase: a universal proton pump of eukaryotes.	ATP6V0A4 TCIRG1	3.05e-04	18	50	2	9210392
Pubmed	Vacuolar and plasma membrane proton-adenosinetriphosphatases.	ATP6V0A4 TCIRG1	3.05e-04	18	50	2	10221984
Pubmed	Structure and properties of the vacuolar (H+)-ATPases.	ATP6V0A4 TCIRG1	3.05e-04	18	50	2	10224039
Pubmed	Structure, function and regulation of the vacuolar (H+)-ATPase.	ATP6V0A4 TCIRG1	3.41e-04	19	50	2	9442887
Pubmed	Proton translocation driven by ATP hydrolysis in V-ATPases.	ATP6V0A4 TCIRG1	4.59e-04	22	50	2	12788495
Pubmed	Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes.	ATP6V0A4 TCIRG1	4.59e-04	22	50	2	14580332
Pubmed	Neurotransmitter release: the dark side of the vacuolar-H+ATPase.	ATP6V0A4 TCIRG1	4.59e-04	22	50	2	14597263
Pubmed	The vacuolar (H+)-ATPases--nature's most versatile proton pumps.	ATP6V0A4 TCIRG1	4.59e-04	22	50	2	11836511
Pubmed	Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation.	ATP6V0A4 TCIRG1	4.59e-04	22	50	2	17662945
Pubmed	ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.	SC5D CHD5 PLEC	5.86e-04	113	50	3	34474245
Pubmed	Receptor-mediated endocytosis: the intracellular journey of transferrin and its receptor.	ATP6V0A4 TCIRG1	5.95e-04	25	50	2	2874839
Pubmed	Congenital Myasthenic Syndromes Overview	LRP4 PLEC	6.44e-04	26	50	2	20301347
Pubmed	Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.	ZNF516 CHD3 GTF3C4	7.85e-04	125	50	3	32891193
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SART3 CHD5 ZNF516 LRP4 TMEM131L	9.63e-04	529	50	5	14621295
Pubmed	Identification of the BRD1 interaction network and its impact on mental disorder risk.	CHD5 CHD3	1.17e-03	35	50	2	27142060
Pubmed	Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.	SURF1 POLG2	1.31e-03	37	50	2	20843780
Pubmed	A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.	SC5D CYP11B2	1.31e-03	37	50	2	26108225
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	CHD5 CHD3	1.38e-03	38	50	2	33283408
Cytoband	22q13	CYP2D7 FAM118A	3.72e-04	26	50	2	22q13
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	2.23e-04	10	41	2	830
GeneFamily	PHD finger proteins\|NuRD complex	CHD5 CHD3	3.26e-04	12	41	2	1305
GeneFamily	PHD finger proteins	PHF20L1 CHD5 CHD3	1.11e-03	90	41	3	88
GeneFamily	V-type ATPases	ATP6V0A4 TCIRG1	1.23e-03	23	41	2	415
GeneFamily	Olfactory receptors, family 11	OR11G2 OR11H7	1.23e-03	23	41	2	159
GeneFamily	Sulfotransferases, membrane bound	TPST1 CHST9	3.18e-03	37	41	2	763
Disease	autosomal recessive osteopetrosis 1 (implicated_via_orthology)	ATP6V0A4 TCIRG1	2.37e-05	5	46	2	DOID:0110942 (implicated_via_orthology)
Disease	renal tubular acidosis (implicated_via_orthology)	ATP6V0A4 TCIRG1	6.62e-05	8	46	2	DOID:14219 (implicated_via_orthology)
Disease	Myasthenic Syndromes, Congenital	LRP4 PLEC	6.42e-04	24	46	2	C0751882
Disease	factor VIII measurement, venous thromboembolism	LRP4 GTF3C4	1.29e-03	34	46	2	EFO_0004286, EFO_0004630
Disease	Mental Retardation, Psychosocial	ZNF526 SC5D SURF1	1.34e-03	139	46	3	C0025363
Disease	Profound Mental Retardation	ZNF526 SC5D SURF1	1.34e-03	139	46	3	C0020796
Disease	Mental deficiency	ZNF526 SC5D SURF1	1.34e-03	139	46	3	C0917816

Protein segments in the cluster

Peptide	Gene	Start	Entry
LVHYEQLVLHPERWM	TPST1	236	O60507
WLESIRMKRYILHFH	EPHA1	921	P21709
YWGHRELMLGEDTRL	CHD5	641	Q8TDI0
WMALLRREIGHFHEK	SH3BP2	121	P78314
YRHLLGVEAMLWERH	RASA4	731	O43374
YRHLLGVEAMLWERH	RASA4B	731	C9J798
FREDLHNRMLLWHGS	PARP2	416	Q9UGN5
QYWLEGMLRHEIGTH	KIAA0895L	271	Q68EN5
EHLWVLGRYMVHLSF	OTOA	256	Q7RTW8
MPSYWREHHIVSLGR	OTOA	891	Q7RTW8
IELMRTFFHWRIGHV	POC5	246	Q8NA72
LIHWDHRLHRPMYFL	OR2T12	46	Q8NG77
HMLENHVERLWAYLT	ITIH1	556	P19827
HVDFIWGLDAPHRMY	LIPM	386	Q5VYY2
WGLDAPHRMYNEIIH	LIPM	391	Q5VYY2
ETLWNLGDHELLHMY	POLG2	301	Q9UHN1
MTHRGEEDWLYERLA	PNPO	246	Q9NVS9
ELMSRYGHRVLELWF	MEI1	791	Q5TIA1
LEWARGHMKYGVLHI	FAM118A	176	Q9NWS6
HKQSYWRHRELIMGE	CHD3	676	Q12873
PILQYRWDIMHRLGE	BEX2	61	Q9BXY8
LGALKHWRRAMELRH	FEM1A	316	Q9BSK4
HWRRAMELRHQGGEY	FEM1A	321	Q9BSK4
MTHNYLRLVHVWLDE	GALNTL5	376	Q7Z4T8
MYVAPVHRDWRVHLA	GPR142	381	Q7Z601
PRREGHYIHWDHVMV	MANEAL	116	Q5VSG8
MILEPWVAYRQHRGH	CYP11B2	111	P19099
LWSRYLLAMERHGVD	SART3	381	Q15020
AVHWDQRLHAPMYIL	OR11G2	86	Q8NGC1
WDHRLHTPMYVLLAN	OR11H7	51	Q8NGC8
GKMLVHFERWSHRYD	PHF20L1	41	A8MW92
RERIWSYLMHVLFDH	OR52I2	331	Q8NH67
EALVHLLHRWFGTDM	TMEM131L	631	A2VDJ0
KRRIMWHIDYRGHGA	TMEM132E	406	Q6IEE7
LRHHYMLCGALLRVW	SBNO2	1161	Q9Y2G9
HWHYRDLEAMARITG	SURF1	226	Q15526
YLLDSHRPVGMDIHW	CHST9	336	Q7L1S5
MHRWRYPSLSLHGIE	CNDP2	306	Q96KP4
FLLLVDLMHRHQRWA	CYP2D7	16	A0A087X1C5
HRFLLRRGEYVLHMW	PIK3CG	471	P48736
YPEVLWMHKRIWHRV	ZNF516	771	Q92618
LTWHRYHLLRLEKDM	TYRP1	221	P17643
LERRHWLNSYMHKLL	PTH2	81	Q96A98
YRELVLLLLQWMRHH	PLEC	421	Q15149
EHMKRVLGEVYLHTW	GTF3C4	686	Q9UKN8
LGRDHWNEMLAYHRK	SYT10	476	Q6XYQ8
MEGLSAFLHALRLHW	ATP6V0A4	796	Q9HBG4
WFRAMAGLRLHQRVH	ZNF526	581	Q8TF50
QLWIFSLMDGHHYRR	WDR27	231	A2RRH5
DMFIYWIHRGLHHRL	SC5D	131	O75845
WGHMGLHYSVRLVEN	XKRX	346	Q6PP77
MEGLSAFLHALRLHW	TCIRG1	791	Q13488
RMYWVDAKHHVIERA	LRP4	611	O75096
RIGWMEFRLLHYAGE	MYO1H	506	Q8N1T3