Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	actin binding	ABRA CCDC88A FMN1 WASF3 ESPNL CLASP2 MIB2 SHROOM2	1.12e-04	479	62	8	GO:0003779
GeneOntologyMolecularFunction	protein kinase binding	CCDC88A CSPG4 TOM1L1 APBA1 APC XIAP CLASP2 HDAC7 MAP3K1 AXIN1	3.30e-04	873	62	10	GO:0019901
GeneOntologyMolecularFunction	cytoskeletal protein binding	ABRA CCDC88A ANK3 FMN1 WASF3 ESPNL APC CLASP2 MIB2 SHROOM2 MAP3K1	5.11e-04	1099	62	11	GO:0008092
GeneOntologyMolecularFunction	kinase binding	CCDC88A CSPG4 TOM1L1 APBA1 APC XIAP CLASP2 HDAC7 MAP3K1 AXIN1	7.47e-04	969	62	10	GO:0019900
GeneOntologyBiologicalProcess	maintenance of protein location in membrane	CCDC88A ANK3	2.49e-05	3	60	2	GO:0072658
GeneOntologyBiologicalProcess	maintenance of protein location in plasma membrane	CCDC88A ANK3	2.49e-05	3	60	2	GO:0072660
GeneOntologyBiologicalProcess	peptidyl-tryptophan modification	DPY19L3 DPY19L2	1.24e-04	6	60	2	GO:0018211
GeneOntologyBiologicalProcess	protein C-linked glycosylation via tryptophan	DPY19L3 DPY19L2	1.24e-04	6	60	2	GO:0018317
GeneOntologyBiologicalProcess	protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	DPY19L3 DPY19L2	1.24e-04	6	60	2	GO:0018406
GeneOntologyBiologicalProcess	protein C-linked glycosylation	DPY19L3 DPY19L2	1.24e-04	6	60	2	GO:0018103
GeneOntologyBiologicalProcess	negative regulation of cellular component organization	ARHGAP24 ANK3 EHMT2 CSPG4 TOM1L1 CDKL3 APC CLASP2 SHROOM2 MAP3K1	1.78e-04	864	60	10	GO:0051129
GeneOntologyBiologicalProcess	regulation of actin filament organization	CCDC88A FMN1 WASF3 CLASP2 SHROOM2 MAP3K1	2.33e-04	300	60	6	GO:0110053
GeneOntologyBiologicalProcess	actin filament bundle assembly	CCDC88A ESPNL CLASP2 SHROOM2 MAP3K1	2.34e-04	191	60	5	GO:0051017
GeneOntologyBiologicalProcess	actin filament bundle organization	CCDC88A ESPNL CLASP2 SHROOM2 MAP3K1	2.57e-04	195	60	5	GO:0061572
GeneOntologyBiologicalProcess	regulation of cytoskeleton organization	RIPOR2 CCDC88A FMN1 WASF3 APC CLASP2 SHROOM2 MAP3K1	2.60e-04	579	60	8	GO:0051493
GeneOntologyBiologicalProcess	positive regulation of supramolecular fiber organization	CCDC88A FMN1 WASF3 APC MAP3K1	2.63e-04	196	60	5	GO:1902905
GeneOntologyBiologicalProcess	regulation of supramolecular fiber organization	CCDC88A FMN1 WASF3 APC CLASP2 SHROOM2 MAP3K1	2.72e-04	438	60	7	GO:1902903
GeneOntologyBiologicalProcess	positive regulation of cytoskeleton organization	CCDC88A FMN1 WASF3 APC MAP3K1	3.24e-04	205	60	5	GO:0051495
Domain	Ank_2	ANK3 EHMT2 ESPNL ANKDD1B MIB2 ANKRD52 ANKS1A	6.26e-06	215	61	7	PF12796
Domain	-	ANK3 EHMT2 ESPNL ANKDD1B MIB2 ANKRD52 ANKS1A	1.58e-05	248	61	7	1.25.40.20
Domain	ANK	ANK3 EHMT2 ESPNL ANKDD1B MIB2 ANKRD52 ANKS1A	1.71e-05	251	61	7	SM00248
Domain	ANK_REPEAT	ANK3 EHMT2 ESPNL ANKDD1B MIB2 ANKRD52 ANKS1A	1.80e-05	253	61	7	PS50088
Domain	Ankyrin_rpt-contain_dom	ANK3 EHMT2 ESPNL ANKDD1B MIB2 ANKRD52 ANKS1A	1.85e-05	254	61	7	IPR020683
Domain	ANK_REP_REGION	ANK3 EHMT2 ESPNL ANKDD1B MIB2 ANKRD52 ANKS1A	1.85e-05	254	61	7	PS50297
Domain	Ankyrin_rpt	ANK3 EHMT2 ESPNL ANKDD1B MIB2 ANKRD52 ANKS1A	2.26e-05	262	61	7	IPR002110
Domain	Dpy19	DPY19L3 DPY19L2	6.27e-05	4	61	2	PF10034
Domain	Dpy-19/Dpy-19-like	DPY19L3 DPY19L2	6.27e-05	4	61	2	IPR018732
Domain	Ank	ANK3 EHMT2 ESPNL MIB2 ANKRD52 ANKS1A	9.82e-05	228	61	6	PF00023
Domain	-	ZNF136 ZNF627 ZKSCAN1 ZSCAN22 KLF9 ZBTB43 ZBTB8B ZNF44	1.57e-03	679	61	8	3.30.160.60
Domain	-	ARHGAP24 PLEKHG7 APBA1 PHETA2 ARHGAP21 ANKS1A	1.70e-03	391	61	6	2.30.29.30
Domain	zf-C2H2	ZNF136 ZNF627 ZKSCAN1 ZSCAN22 KLF9 ZBTB43 ZBTB8B ZNF44	1.79e-03	693	61	8	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF136 ZNF627 ZKSCAN1 ZSCAN22 KLF9 ZBTB43 ZBTB8B ZNF44	1.81e-03	694	61	8	IPR013087
Domain	PH_dom-like	ARHGAP24 PLEKHG7 APBA1 PHETA2 ARHGAP21 ANKS1A	2.62e-03	426	61	6	IPR011993
Domain	ZINC_FINGER_C2H2_2	ZNF136 ZNF627 ZKSCAN1 ZSCAN22 KLF9 ZBTB43 ZBTB8B ZNF44	3.57e-03	775	61	8	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF136 ZNF627 ZKSCAN1 ZSCAN22 KLF9 ZBTB43 ZBTB8B ZNF44	3.62e-03	777	61	8	PS00028
Domain	PID	APBA1 ANKS1A	3.76e-03	28	61	2	PF00640
Domain	Znf_C2H2-like	ZNF136 ZNF627 ZKSCAN1 ZSCAN22 KLF9 ZBTB43 ZBTB8B ZNF44	4.19e-03	796	61	8	IPR015880
Domain	Znf_C2H2	ZNF136 ZNF627 ZKSCAN1 ZSCAN22 KLF9 ZBTB43 ZBTB8B ZNF44	4.49e-03	805	61	8	IPR007087
Domain	ZnF_C2H2	ZNF136 ZNF627 ZKSCAN1 ZSCAN22 KLF9 ZBTB43 ZBTB8B ZNF44	4.59e-03	808	61	8	SM00355
Domain	PID	APBA1 ANKS1A	4.89e-03	32	61	2	PS01179
Domain	Death_domain	ANK3 ANKDD1B	6.84e-03	38	61	2	IPR000488
Domain	DEATH_DOMAIN	ANK3 ANKDD1B	6.84e-03	38	61	2	PS50017
Domain	PTB	APBA1 ANKS1A	7.56e-03	40	61	2	SM00462
Domain	PTB/PI_dom	APBA1 ANKS1A	7.93e-03	41	61	2	IPR006020
Domain	PDZ	APBA1 SHROOM2 ARHGAP21	1.10e-02	141	61	3	PF00595
Domain	PDZ	APBA1 SHROOM2 ARHGAP21	1.26e-02	148	61	3	SM00228
Domain	PH	ARHGAP24 PLEKHG7 PHETA2 ARHGAP21	1.29e-02	278	61	4	SM00233
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	KIAA1671 CCDC88A APC CLASP2 ARHGAP21 AXIN1 ANKS1A	9.51e-08	209	62	7	36779422
Pubmed	MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway.	APC MAP3K1 AXIN1	4.50e-07	9	62	3	20128690
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	KIAA1671 CCDC88A ANK3 APC ARHGAP21 AXIN1 ANKS1A	4.50e-07	263	62	7	34702444
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1A ARHGAP24 CCDC88A ANK3 ZKSCAN1 EHMT2 APC CLASP2 ARHGAP21 LRRFIP2 ANKS1A	9.70e-07	963	62	11	28671696
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIAA1671 USP31 CCDC88A APC XIAP CLASP2 HDAC7 ARHGAP21 DOP1B ANKS1A	2.76e-06	861	62	10	36931259
Pubmed	Two novel alleles of tottering with distinct Ca(v)2.1 calcium channel neuropathologies.	CACNA1A FMN1	3.13e-06	2	62	2	18597946
Pubmed	Targeting the NAD+ salvage pathway suppresses APC mutation-driven colorectal cancer growth and Wnt/β-catenin signaling via increasing Axin level.	APC AXIN1	3.13e-06	2	62	2	32005247
Pubmed	Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain.	CCDC88A CLASP2	3.13e-06	2	62	2	24211587
Pubmed	Genetic alterations in members of the Wnt pathway in acute leukemia.	APC AXIN1	3.13e-06	2	62	2	21902576
Pubmed	Structural basis of the Axin-adenomatous polyposis coli interaction.	APC AXIN1	3.13e-06	2	62	2	10811618
Pubmed	Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling.	MAP3K1 AXIN1	3.13e-06	2	62	2	10575011
Pubmed	Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex.	DPY19L3 DPY19L2 SCMH1	6.02e-06	20	62	3	22028030
Pubmed	CTNNB1, AXIN1 and APC expression analysis of different medulloblastoma variants.	APC AXIN1	9.37e-06	3	62	2	23525311
Pubmed	Genetic Polymorphisms in APC, DVL2, and AXIN1 Are Associated with Susceptibility, Advanced TNM Stage or Tumor Location in Colorectal Cancer.	APC AXIN1	9.37e-06	3	62	2	31723073
Pubmed	Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase.	MAP3K1 AXIN1	9.37e-06	3	62	2	10829020
Pubmed	AXIN1 Expression and Localization in Meningiomas and Association to Changes of APC and E-cadherin.	APC AXIN1	9.37e-06	3	62	2	27630299
Pubmed	Krüppel-like factor 9 (KLF9) prevents colorectal cancer through inhibition of interferon-related signaling.	KLF9 APC	9.37e-06	3	62	2	26210742
Pubmed	Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1.	APC AXIN1	9.37e-06	3	62	2	15981102
Pubmed	different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli.	APC AXIN1	9.37e-06	3	62	2	24722208
Pubmed	Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma.	APC AXIN1	9.37e-06	3	62	2	16163548
Pubmed	Glycogen synthase kinase 3 beta is a natural activator of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1).	MAP3K1 AXIN1	9.37e-06	3	62	2	12584189
Pubmed	Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A.	APC AXIN1	9.37e-06	3	62	2	11297546
Pubmed	Axin-independent phosphorylation of APC controls beta-catenin signaling via cytoplasmic retention of beta-catenin.	APC AXIN1	9.37e-06	3	62	2	17418091
Pubmed	Putative tumor suppressor EDD interacts with and up-regulates APC.	APC AXIN1	9.37e-06	3	62	2	18076571
Pubmed	Ubiquitylation and degradation of adenomatous polyposis coli by MKRN1 enhances Wnt/β-catenin signaling.	APC AXIN1	9.37e-06	3	62	2	29713058
Pubmed	A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis.	APC AXIN1	9.37e-06	3	62	2	23671587
Pubmed	Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain.	CSPG4 APC NRG2	1.53e-05	27	62	3	36915679
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF136 ZNF627 ZKSCAN1 EHMT2 ZNF44	1.84e-05	181	62	5	37372979
Pubmed	Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination.	APC AXIN1	1.87e-05	4	62	2	16199882
Pubmed	Loss of protein-tyrosine phosphatase α (PTPα) increases proliferation and delays maturation of oligodendrocyte progenitor cells.	CSPG4 APC	1.87e-05	4	62	2	22354965
Pubmed	Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon.	APC AXIN1	1.87e-05	4	62	2	11487578
Pubmed	Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin.	APC AXIN1	1.87e-05	4	62	2	15355978
Pubmed	Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level.	APC AXIN1	1.87e-05	4	62	2	9734785
Pubmed	Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation.	MAP3K1 AXIN1	1.87e-05	4	62	2	12878610
Pubmed	Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC.	APC AXIN1	1.87e-05	4	62	2	17588722
Pubmed	The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death.	APC XIAP	1.87e-05	4	62	2	16007220
Pubmed	A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction.	APC AXIN1	1.87e-05	4	62	2	26393419
Pubmed	Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon.	APC AXIN1	1.87e-05	4	62	2	12072559
Pubmed	Role of CLASP2 in microtubule stabilization and the regulation of persistent motility.	APC CLASP2	3.12e-05	5	62	2	17113391
Pubmed	The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions.	APC AXIN1	3.12e-05	5	62	2	16188939
Pubmed	Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.	APC AXIN1	3.12e-05	5	62	2	9482734
Pubmed	The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin.	APC AXIN1	3.12e-05	5	62	2	16753179
Pubmed	The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/β-catenin signalling pathway.	APC AXIN1	3.12e-05	5	62	2	26941395
Pubmed	LEF1 and B9L shield β-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors.	APC AXIN1	3.12e-05	5	62	2	24419084
Pubmed	Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.	APC AXIN1	3.12e-05	5	62	2	15520370
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	APC HDAC7 ARHGAP21 ANKS1A	3.41e-05	102	62	4	15778465
Pubmed	Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer.	APC AXIN1	4.67e-05	6	62	2	18708403
Pubmed	An EB1-binding motif acts as a microtubule tip localization signal.	APC CLASP2	4.67e-05	6	62	2	19632184
Pubmed	An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.	APC AXIN1	4.67e-05	6	62	2	10228155
Pubmed	Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways.	MAP3K1 AXIN1	4.67e-05	6	62	2	11884395
Pubmed	Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF.	APC AXIN1	4.67e-05	6	62	2	18786926
Pubmed	Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.	APC AXIN1	4.67e-05	6	62	2	11955436
Pubmed	USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin.	APC AXIN1	4.67e-05	6	62	2	31519875
Pubmed	Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity.	APC AXIN1	4.67e-05	6	62	2	16293619
Pubmed	Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium.	SLC12A3 APC	4.67e-05	6	62	2	15550389
Pubmed	CDK5 activator protein p25 preferentially binds and activates GSK3β.	APC AXIN1	4.67e-05	6	62	2	25331900
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	CCDC88A APBA1 APC ZFC3H1	6.44e-05	120	62	4	31413325
Pubmed	Ubiquitin ligase E6AP mediates nonproteolytic polyubiquitylation of β-catenin independent of the E6 oncoprotein.	APC AXIN1	6.53e-05	7	62	2	27902311
Pubmed	ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.	APC CLASP2	6.53e-05	7	62	2	20937854
Pubmed	Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis.	CSPG4 APC	6.53e-05	7	62	2	21849552
Pubmed	YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response.	APC AXIN1	6.53e-05	7	62	2	24976009
Pubmed	Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation.	APC AXIN1	6.53e-05	7	62	2	17318191
Pubmed	A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.	MAP3K1 AXIN1	6.53e-05	7	62	2	17681137
Pubmed	GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.	APC AXIN1	6.53e-05	7	62	2	10698523
Pubmed	Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling.	APC AXIN1	6.53e-05	7	62	2	18316368
Pubmed	Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle.	CSPG4 APC	6.53e-05	7	62	2	28077718
Pubmed	Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome.	CSPG4 APC	6.53e-05	7	62	2	32817053
Pubmed	Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization.	APC AXIN1	6.53e-05	7	62	2	10330403
Pubmed	Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation.	APC AXIN1	6.53e-05	7	62	2	15327768
Pubmed	Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function.	APC AXIN1	6.53e-05	7	62	2	15327769
Pubmed	Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.	APC AXIN1	6.53e-05	7	62	2	12000790
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	ANK3 APBA1 CLASP2 ARHGAP21	8.28e-05	128	62	4	30995482
Pubmed	Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.	SCMH1 DCBLD1 TFAP2B ANKS1A	8.53e-05	129	62	4	23563607
Pubmed	Palmitoylation of BMPR1a regulates neural stem cell fate.	CSPG4 APC	8.69e-05	8	62	2	31772009
Pubmed	Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation.	APC AXIN1	8.69e-05	8	62	2	34352208
Pubmed	Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain.	CSPG4 APC	8.69e-05	8	62	2	26345464
Pubmed	Mutations in MAP3K1 tilt the balance from SOX9/FGF9 to WNT/β-catenin signaling.	MAP3K1 AXIN1	8.69e-05	8	62	2	24135036
Pubmed	ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.	APC AXIN1	8.69e-05	8	62	2	32533114
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KIAA1671 CCDC88A EHMT2 APC ANKRD52 ARHGAP21	1.01e-04	418	62	6	34709266
Pubmed	RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer.	APC AXIN1	1.12e-04	9	62	2	32965059
Pubmed	Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain.	ANK3 TFAP2B	1.12e-04	9	62	2	7615634
Pubmed	Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells.	SCMH1 TFAP2B	1.12e-04	9	62	2	12504852
Pubmed	Expression of discoidin domain receptor 1 during mouse brain development follows the progress of myelination.	CSPG4 APC	1.12e-04	9	62	2	16603319
Pubmed	Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.	APC AXIN1	1.12e-04	9	62	2	12820959
Pubmed	Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.	APC AXIN1	1.12e-04	9	62	2	9601641
Pubmed	The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.	APC AXIN1	1.12e-04	9	62	2	34489457
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	RIPOR2 ANK3 FMN1 DDX42 APC XIAP CLASP2 SHROOM2 ARHGAP21	1.24e-04	1084	62	9	11544199
Pubmed	The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc.	APC AXIN1	1.39e-04	10	62	2	19131971
Pubmed	EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis.	APC CLASP2	1.39e-04	10	62	2	23001180
Pubmed	ASCL1 regulates proliferation of NG2-glia in the embryonic and adult spinal cord.	CSPG4 APC	1.39e-04	10	62	2	29683222
Pubmed	Diminished Ventral Oligodendrocyte Precursor Generation Results in the Subsequent Over-production of Dorsal Oligodendrocyte Precursors of Aberrant Morphology and Function.	CSPG4 APC	1.39e-04	10	62	2	32450295
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	KIAA1671 APC CLASP2 ANKRD52 HDAC7 ANKS1A	1.44e-04	446	62	6	24255178
Pubmed	A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder.	CSPG4 APC	1.70e-04	11	62	2	32015540
Pubmed	Neogenin-loss in neural crest cells results in persistent hyperplastic primary vitreous formation.	CSPG4 TFAP2B	2.04e-04	12	62	2	31336386
Pubmed	Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.	APC AXIN1	2.04e-04	12	62	2	22682247
Pubmed	HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.	APC AXIN1	2.41e-04	13	62	2	23277359
Pubmed	WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.	WASF3 APC	2.41e-04	13	62	2	16723544
Pubmed	Constitutional mislocalization of Pten drives precocious maturation in oligodendrocytes and aberrant myelination in model of autism spectrum disorder.	CSPG4 APC	2.41e-04	13	62	2	30664625
Pubmed	Survival control of oligodendrocyte progenitor cells requires the transcription factor 4 during olfactory bulb development.	CSPG4 APC	2.81e-04	14	62	2	33462220
Pubmed	Beta-catenin is temporally regulated during normal liver development.	APC AXIN1	2.81e-04	14	62	2	15057752
Cytoband	6p21.31	EHMT2 ANKS1A	1.42e-03	41	62	2	6p21.31
GeneFamily	Ankyrin repeat domain containing	ANK3 EHMT2 ESPNL ANKDD1B MIB2 ANKRD52 ANKS1A	1.51e-06	242	43	7	403
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF136 ZNF627 ZKSCAN1 ZSCAN22 KLF9 ZBTB43 ZBTB8B ZNF44	2.51e-04	718	43	8	28
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGAP24 PLEKHG7 PHETA2 ARHGAP21	1.43e-03	206	43	4	682
GeneFamily	PDZ domain containing	APBA1 SHROOM2 ARHGAP21	5.62e-03	152	43	3	1220
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP24 ARHGAP21	6.30e-03	50	43	2	721
CoexpressionAtlas	DevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#5_top-relative-expression-ranked_1000	USP31 ANK3 ZKSCAN1 APC XIAP CLASP2	4.27e-06	146	62	6	gudmap_developingKidney_e15.5_Cap mesenchyme_1000_k5
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#2_top-relative-expression-ranked_500	USP31 APC XIAP CLASP2 TFAP2B	6.19e-06	89	62	5	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_500_k2
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_500	ARHGAP24 ANK3 ZKSCAN1 APC XIAP TFAP2B	6.25e-06	156	62	6	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_500_k5
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#1_top-relative-expression-ranked_1000	USP31 SCMH1 APC XIAP CLASP2 TFAP2B	3.29e-05	209	62	6	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000_k1
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_1000	ARHGAP24 ANK3 ZKSCAN1 SCMH1 APC XIAP TFAP2B	5.75e-05	339	62	7	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_1000_k5
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#5_top-relative-expression-ranked_500	USP31 ANK3 ZKSCAN1 APC XIAP	7.46e-05	149	62	5	gudmap_developingLowerUrinaryTract_e14.5_ urethra_500_k5
CoexpressionAtlas	DevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#5_top-relative-expression-ranked_500	USP31 ANK3 APC XIAP	7.99e-05	78	62	4	gudmap_developingKidney_e15.5_Cap mesenchyme_500_k5
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_k-means-cluster#4_top-relative-expression-ranked_500	ZKSCAN1 SCMH1 APC XIAP TFAP2B	1.14e-04	163	62	5	gudmap_developingKidney_e15.5_cortic collect duct_500_k4
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_1000	USP31 ANK3 ZKSCAN1 EHMT2 APC XIAP CLASP2	1.27e-04	385	62	7	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k4
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#5_top-relative-expression-ranked_500	USP31 ANK3 ZKSCAN1 APC XIAP	2.56e-04	194	62	5	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k5_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#2_top-relative-expression-ranked_1000	USP31 ANK3 ZKSCAN1 APC XIAP CLASP2	2.95e-04	312	62	6	gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000_k2
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#2_top-relative-expression-ranked_500	USP31 ANK3 ZKSCAN1 APC XIAP	3.61e-04	209	62	5	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500_k2
CoexpressionAtlas	DevelopingKidney_e15.5_Medullary collecting duct_emap-28063_k-means-cluster#3_top-relative-expression-ranked_500	ANK3 APC XIAP TFAP2B	3.82e-04	117	62	4	gudmap_developingKidney_e15.5_Medullary collecting duct_500_k3
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_1000	ARHGAP24 ANK3 ZKSCAN1 SCMH1 APC DCBLD1 XIAP TFAP2B DOP1B	3.90e-04	774	62	9	gudmap_developingKidney_e15.5_cortic collect duct_1000
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#4_top-relative-expression-ranked_200	APC XIAP TFAP2B	4.47e-04	51	62	3	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_200_k4
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B\|GI_small-bowel / Manually curated celltypes from each tissue	RIPOR2 ARHGAP24 SLC12A3 PLEKHG7 ESPNL	3.73e-06	168	62	5	5535c1b8b7fde7b59a1bc0580cebdfa963aa1c39
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B-Memory_B_cells\|GI_small-bowel / Manually curated celltypes from each tissue	RIPOR2 ARHGAP24 SLC12A3 PLEKHG7 ESPNL	3.73e-06	168	62	5	8e025bb0541746e232b77ac0e31412ae71420c47
ToppCell	10x5'-GI_large-bowel-Lymphocytic_B-Memory_B_cells\|GI_large-bowel / Manually curated celltypes from each tissue	RIPOR2 ARHGAP24 PLEKHG7 ESPNL MAP3K1	7.14e-06	192	62	5	31f7245bce79969674a775ecf175e7c6af68b503
ToppCell	B_cells-Activate_B_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	CACNA1A RIPOR2 ARHGAP24 PLEKHG7 MAP3K1	7.32e-06	193	62	5	b6da81920cf2e55f87ec8d4b2b5530cbf7ba2155
ToppCell	Control-B_memory-0\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RIPOR2 ARHGAP24 ANK3 RELL2 PLEKHG7	7.32e-06	193	62	5	b8d64cc0abc4a3311e172e7e48a7de0f2188effb
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2\|World / Primary Cells by Cluster	RIPOR2 CCDC88A ANK3 APC ANKS1A	7.50e-06	194	62	5	b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2-10\|World / Primary Cells by Cluster	RIPOR2 CCDC88A ANK3 APC ANKS1A	7.50e-06	194	62	5	81e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DPY19L3 ANK3 FMN1 TOM1L1 DOP1B	8.70e-06	200	62	5	0eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RIPOR2 DPY19L2 ST3GAL1 DOP1B	8.24e-05	165	62	4	dc570154baed59ed109e5369589448e075ba66a9
ToppCell	droplet-Marrow-nan-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88A ZSCAN22 KLF9 ANKRD52	9.04e-05	169	62	4	5f5bec13208f4c3b6eacbba180c8a6402743b76e
ToppCell	mild_COVID-19_(asymptomatic)-B_memory\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	ARHGAP24 SLC12A3 ANK3 PLEKHG7	9.90e-05	173	62	4	9082ad77b44f65b72094df6e502cce81b62fe81a
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DPY19L3 FMN1 DCBLD1 CCDC168	1.01e-04	174	62	4	ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DPY19L2 SLC12A3 FMN1 NRG2	1.18e-04	181	62	4	e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCell	droplet-Liver-nan-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DCBLD1 PHETA2 ANKRD52 HDAC7	1.18e-04	181	62	4	fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 DPY19L2 SLC12A3 FMN1	1.20e-04	182	62	4	5f513bbb7125956eb528e3120de3fd776770a7c3
ToppCell	droplet-Heart-4Chambers-18m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK3 CDKL3 CLASP2 TFAP2B	1.20e-04	182	62	4	6fdaf3c8c3952a8f14dd7288e523ed58eb1d3517
ToppCell	facs-Lung-24m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l14\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EHMT2 CSPG4 TOM1L1 TMEM79	1.23e-04	183	62	4	6e5b39c0170d62eb7fdd411dcfff51ed176573d0
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ABRA PLEKHG7 SHLD1 MAP3K1	1.31e-04	186	62	4	55b239834b96b1f7787ec77a7d19796d617bbbf0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 SLC12A3 FMN1 TFAP2B	1.39e-04	189	62	4	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 SLC12A3 FMN1 TFAP2B	1.42e-04	190	62	4	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 HDAC7 TFAP2B MAP3K1	1.42e-04	190	62	4	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 HDAC7 TFAP2B MAP3K1	1.45e-04	191	62	4	5a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 HDAC7 TFAP2B MAP3K1	1.45e-04	191	62	4	55ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP24 DCBLD1 ST3GAL1 MAP3K1	1.48e-04	192	62	4	2de242d81dc085ae734eb7d1f091af9a542e0866
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP24 DCBLD1 ST3GAL1 MAP3K1	1.48e-04	192	62	4	ba2a683472a8b785dbf666dc6e94356d879486c3
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	DPY19L2 ANK3 ST3GAL1 LRRFIP2	1.48e-04	192	62	4	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	ILEUM-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	USP31 CCDC88A WASF3 MAP3K1	1.48e-04	192	62	4	d43caf42ec744e895137f31ef65a990e250669d2
ToppCell	B_cells-Memory_B_cells\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	RIPOR2 ARHGAP24 PLEKHG7 MAP3K1	1.48e-04	192	62	4	eef591095921ede098f41a2b81897b18915bb753
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 HDAC7 TFAP2B MAP3K1	1.51e-04	193	62	4	80e058c224749b5fe0ba3e944b48317c2371cb63
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 HDAC7 TFAP2B MAP3K1	1.51e-04	193	62	4	b991fbbb4618401624f0b3045f0e81a606d3a763
ToppCell	368C-Fibroblasts-Fibroblast-K_(Pericytes)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	KIAA1671 ABRA RIPOR2 CSPG4	1.51e-04	193	62	4	5ec917931b438dd0e7fb03eb6af459d3ef6b84ba
ToppCell	368C-Fibroblasts-Fibroblast-K_(Pericytes)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	KIAA1671 ABRA RIPOR2 CSPG4	1.51e-04	193	62	4	5260ac95a15cc43a19909badad0c7e3854da920d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 HDAC7 TFAP2B MAP3K1	1.51e-04	193	62	4	263d185af6ed80e639f864e4966268e0862c61dc
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-Memory_B\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RIPOR2 ARHGAP24 PLEKHG7 MAP3K1	1.57e-04	195	62	4	f43dacc972dc4df574c4639952d3be9fc4201d33
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 SLC12A3 ANK3 TFAP2B	1.57e-04	195	62	4	3123e02d2894c83962ba402085b5e6422ebf8c73
ToppCell	Children_(3_yrs)-Immune-monocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RIPOR2 CCDC88A FMN1 MAP3K1	1.60e-04	196	62	4	cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCell	COVID-19-Myeloid-Monocytes\|COVID-19 / group, cell type (main and fine annotations)	RIPOR2 CCDC88A FMN1 MAP3K1	1.60e-04	196	62	4	04d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCell	Influenza-Influenza_Severe-Myeloid-pDC\|Influenza_Severe / Disease, condition lineage and cell class	SLC12A3 RELL2 SCMH1 NRG2	1.63e-04	197	62	4	e8e6f71e6dc8a695e4321a18543c1df63dd62f3e
ToppCell	Parenchyma_Control_(B.)-Immune-TX-MoAM-4\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	USP31 ZNF136 RELL2 DOP1B	1.63e-04	197	62	4	dc1c55e3aacc9d60d0f111c2f20f150ca296f011
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP24 ANK3 SCMH1 FMN1	1.66e-04	198	62	4	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	B_cells-Activate_B_cells\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	RIPOR2 ARHGAP24 ANK3 ST3GAL1	1.66e-04	198	62	4	a663082d7fbd6db11d3d3024bbb8ba00183e19f8
ToppCell	Children_(3_yrs)-Immune-monocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RIPOR2 CCDC88A FMN1 MAP3K1	1.73e-04	200	62	4	881ab995c90d75fd987d6e8f1f926a4bfcc4235f
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DPY19L3 FMN1 TOM1L1 DOP1B	1.73e-04	200	62	4	c450a15e21fa72d071ed6e3b9f22de557a0f3cea
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal-Cortical_neuron\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	CACNA1A USP31 ANK3 DOP1B	1.73e-04	200	62	4	5b3df61ff421846ef4cabf1bd5355534c8b95509
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KIAA1671 ANK3 TOM1L1 DOP1B	1.73e-04	200	62	4	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal\|5w / Sample Type, Dataset, Time_group, and Cell type.	RIPOR2 ANK3 APC CLASP2	1.73e-04	200	62	4	9b5753726c17dda98d7384a60f26a5eaf4f6c4d6
Drug	Tranylcypromine hydrochloride [1986-47-6]; Up 200; 23.6uM; PC3; HT_HG-U133A	CCDC88A ZKSCAN1 ZBTB43 APC KLK12 AXIN1	1.55e-05	196	62	6	2101_UP
Drug	Hecogenin [467-55-0]; Up 200; 9.2uM; HL60; HT_HG-U133A	RIPOR2 SLC12A3 CSPG4 APC NRG2 HDAC7	1.64e-05	198	62	6	2716_UP
Drug	Hexylcaine hydrochloride [532-76-3]; Down 200; 13.4uM; MCF7; HT_HG-U133A	ERCC8 SCMH1 ZBTB43 CDKL3 APC DOP1B	1.69e-05	199	62	6	6244_DN
Disease	Hepatoblastoma	APC AXIN1	6.27e-05	6	61	2	C0206624
Disease	HEPATOCELLULAR CARCINOMA	APC AXIN1	1.50e-04	9	61	2	114550
Disease	Hepatocellular carcinoma	APC AXIN1	1.50e-04	9	61	2	cv:C2239176
Disease	alopecia areata (is_marker_for)	EHMT2 HDAC7	1.87e-04	10	61	2	DOID:986 (is_marker_for)
Disease	cortical surface area measurement	CACNA1A ERCC8 CCDC88A ANK3 APC TFAP2B ARHGAP21 MAP3K1 AXIN1 ANKS1A	4.05e-04	1345	61	10	EFO_0010736
Disease	Body Weight	KLF9 TFAP2B	4.34e-04	15	61	2	C0005910
Disease	Splenomegaly	APC XIAP	9.46e-04	22	61	2	C0038002
Disease	arachidonic acid measurement	CACNA1A RBMXL2	1.22e-03	25	61	2	EFO_0006808
Disease	radius bone mineral density	CACNA1A MAP3K1	2.26e-03	34	61	2	EFO_0007933

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSREGPYGRESDHHA	CACNA1A	891	O00555
PYGRESDHHAREGSL	CACNA1A	896	O00555
DSYLPSHRENEHGIV	AADACL2	226	Q6P093
FRFRLSDGEHTSPGH	CSPG4	1556	Q6UVK1
PADRISSSDLLHHEY	CDKL3	271	Q8IVW4
GDTPLHIAARESYHD	EHMT2	851	Q96KQ7
RIHGSAAREEDEHPY	ANKS1A	441	Q92625
HPHYEDSSLRERTRA	DPY19L3	596	Q6ZPD9
TYRRAEPHTPSSHDA	ANKRD52	501	Q8NB46
YEDRHDGVPSHSSRL	TFAP2B	26	Q92481
SNRSELYLDLHPDHS	FMN1	671	Q68DA7
RSDELTRHYRTHTGE	KLF9	186	Q13886
HSGRPFTTYDADHDS	FCN3	226	O75636
VSHHVDPSLRDEDGY	ESPNL	291	Q6ZVH7
PEDSPHVGHRRTDYV	KIAA1671	966	Q9BY89
HVGHRRTDYVSPTAS	KIAA1671	971	Q9BY89
PGYLGASTSHEHDLR	KLK12	96	Q9UKR0
TAHHGRALPEDSLFE	DOP1B	1406	Q9Y3R5
GDGYRHPESSSRHTD	DDX42	841	Q86XP3
EERDGLHFLPHASSS	CCDC88A	216	Q3V6T2
YHDSVDSLRDSPHSE	NRG2	576	O14511
DSLRDSPHSERYVSA	NRG2	581	O14511
VNHPHYEDADLRART	DPY19L2	656	Q6NUT2
GRDHPDVHRYSVETV	ERCC8	91	Q13216
HRSSHHRPYLGVEDA	LRRFIP2	86	Q9Y608
LSHPRDYESKSDHRS	ARHGAP24	601	Q8N264
YRHAEREHPETSSAT	BCLAF3	261	A2AJT9
LEPHSHGARSRGYSE	AXIN1	566	O15169
THRLFHRGEDEPYSE	APBA1	171	Q02410
SGYTPLHLSAREGHE	ANK3	531	Q12955
CLSHTEHPDREYETI	CCDC168	176	Q8NDH2
DPSVLYISLHRHDDG	HDAC7	721	Q8WUI4
DHPDLITCLERASHY	DCBLD1	151	Q8N8Z6
LAHAFDRYETAHSRP	MIB2	126	Q96AX9
LEGHAAFSSRHFREP	ITPRIPL2	81	Q3MIP1
RSHDFYSHELSSPVD	MAP3K1	496	Q13233
KRYGLHEHRDGSPTD	RELL2	176	Q8NC24
SHRDPYATSVGHLIE	TOM1L1	6	O75674
THHLVYPESFRELGD	ST3GAL1	186	Q11201
QRHSRDTHFYPLEEG	SHLD1	161	Q8IYI0
RGYSPHQHPRTSEDT	SHROOM2	776	Q13796
GDHLSRGSHREPFES	RBMXL2	271	O75526
SYRSVHPEARGHLSE	RIPOR2	701	Q9Y4F9
SHSHDRYLPGETFVL	SCMH1	481	Q96GD3
HLSHRYERDAGVLEP	ABRA	126	Q8N0Z2
REEHHESIRDPSTGF	ANKDD1B	396	A6NHY2
EDRVRGSFAFDSPHH	APC	1831	P25054
SRHHSRSTGALYAPE	CLASP2	551	O75122
EHEYLPSNSSTEHDR	ZBTB43	191	O43298
RSVAHYALSDSPADH	PHETA2	6	Q6ICB4
DYPSRFRTHERSHTG	ZNF136	206	P52737
FRTHERSHTGEKPYE	ZNF136	211	P52737
HFALDRPSETHADYL	XIAP	126	P98170
RYHRPHSEDGEASIV	PIGX	151	Q8TBF5
AAEHEYRPPSASARH	WASF3	281	Q9UPY6
ATESRLDYPDHARSA	TMEM79	371	Q9BSE2
YPSLFRIHERSHTGE	ZNF627	206	Q7L945
EGRHLHALAFDSRPS	SLC12A3	96	P55017
RYEEASGPHEALAHL	ZSCAN22	56	P10073
EELHPSRFYEHRRSS	PLEKHG7	171	Q6ZR37
SYQEPSDSHSRREHK	USP31	921	Q70CQ4
HRIHARERASEYSPA	ZKSCAN1	536	P17029
HTGPSHRTEEVRYGV	ARHGAP21	291	Q5T5U3
HASERGHLRGPSSYR	ZFC3H1	91	O60293
PDYSSYLRHERTHTG	ZNF44	311	P15621
ADHHFSRSLEGRPEG	ZBTB8B	296	Q8NAP8