Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmetalloendopeptidase activity

MEP1B ADAMTSL2

5.15e-03120182GO:0004222
GeneOntologyCellularComponentCHD-type complex

MTA3 MTA2

8.41e-0517172GO:0090545
GeneOntologyCellularComponentNuRD complex

MTA3 MTA2

8.41e-0517172GO:0016581
GeneOntologyCellularComponenthistone deacetylase complex

MTA3 MTA2

2.14e-0385172GO:0000118
GeneOntologyCellularComponentazurophil granule lumen

FUCA2 GALNS

2.44e-0391172GO:0035578
GeneOntologyCellularComponentSWI/SNF superfamily-type complex

MTA3 MTA2

2.71e-0396172GO:0070603
DomainGOLGA6L

GOLGA6L9 GOLGA6L19 GOLGA6L10

2.10e-086203IPR026737
DomainGolgin_A

GOLGA6L9 GOLGA6L19 GOLGA6L10

8.48e-0718203IPR024858
DomainGOLGA2L5

GOLGA6L9 GOLGA6L19 GOLGA6L10

8.48e-0718203PF15070
DomainBAH

MTA3 MTA2

5.96e-0511202SM00439
DomainBAH

MTA3 MTA2

5.96e-0511202PF01426
DomainBAH_dom

MTA3 MTA2

5.96e-0511202IPR001025
DomainBAH

MTA3 MTA2

5.96e-0511202PS51038
DomainZnF_GATA

MTA3 MTA2

7.14e-0512202SM00401
DomainELM2

MTA3 MTA2

8.44e-0513202PF01448
DomainELM2

MTA3 MTA2

8.44e-0513202PS51156
DomainELM2_dom

MTA3 MTA2

8.44e-0513202IPR000949
DomainELM2

MTA3 MTA2

8.44e-0513202SM01189
DomainGATA

MTA3 MTA2

1.13e-0415202PF00320
DomainZnf_GATA

MTA3 MTA2

1.13e-0415202IPR000679
DomainGATA_ZN_FINGER_1

MTA3 MTA2

1.30e-0416202PS00344
DomainGATA_ZN_FINGER_2

MTA3 MTA2

1.30e-0416202PS50114
DomainSANT_dom

MTA3 MTA2

3.49e-0426202IPR017884
DomainSANT

MTA3 MTA2

4.05e-0428202PS51293
DomainMyb_DNA-binding

MTA3 MTA2

6.35e-0435202PF00249
DomainMYB_LIKE

MTA3 MTA2

7.48e-0438202PS50090
DomainSANT

MTA3 MTA2

1.29e-0350202SM00717
DomainSANT/Myb

MTA3 MTA2

1.40e-0352202IPR001005
PathwayREACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION

MTA3 MTA2

2.72e-0427132MM15537
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_BROWN_AND_BEIGE_ADIPOCYTE_DIFFERENTIATION

MTA3 MTA2

3.60e-0431132M48258
PathwayWP_EFFECT_OF_PROGERIN_ON_GENES_INVOLVED_IN_PROGERIA

MTA3 MTA2

5.13e-0437132M39756
PathwayREACTOME_RNA_POLYMERASE_I_TRANSCRIPTION

MTA3 MTA2

8.29e-0447132MM15428
PathwayREACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_INITIATION

MTA3 MTA2

8.29e-0447132M1095
PathwayREACTOME_HDACS_DEACETYLATE_HISTONES

MTA3 MTA2

1.13e-0355132MM14932
PathwayREACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION

MTA3 MTA2

1.39e-0361132M27811
PathwayREACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION

MTA3 MTA2

2.10e-0375132M27343
PathwayREACTOME_HDACS_DEACETYLATE_HISTONES

MTA3 MTA2

3.27e-0394132M27230
PathwayREACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS_BY_PIWI_INTERACTING_RNAS_PIRNAS

MTA3 MTA2

3.48e-0397132M48262
PathwayREACTOME_PTEN_REGULATION

MTA3 MTA2

3.55e-0398132MM15348
PathwayREACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION

MTA3 MTA2

4.06e-03105132M27425
PathwayREACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS_BY_KRAB_ZFP_PROTEINS

MTA3 MTA2

4.22e-03107132M48260
PathwayWP_NF1_COPY_NUMBER_VARIATION_SYNDROME

ADAMTSL4-AS1 RTN4R

4.37e-03109132M48084
PathwayREACTOME_ADIPOGENESIS

MTA3 MTA2

4.45e-03110132M48259
PathwayREACTOME_RNA_POLYMERASE_I_TRANSCRIPTION

MTA3 MTA2

4.45e-03110132M27696
Pubmed

Inhibition of MTA2 and MTA3 induces mesendoderm specification of human embryonic stem cells.

MTA3 MTA2

3.82e-07222233744762
Pubmed

Structure, expression and functions of MTA genes.

MTA3 MTA2

1.15e-06322226869315
Pubmed

Identification and characterization of metastasis-associated gene/protein 1 (MTA1).

MTA3 MTA2

1.15e-06322225315816
Pubmed

The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment.

MTA3 MTA2

3.82e-06522231036553
Pubmed

The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex.

MTA3 MTA2

1.07e-05822218067919
Pubmed

Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation.

MTA3 MTA2

1.07e-05822210471500
Pubmed

MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer.

MTA3 MTA2

1.07e-05822212705869
Pubmed

Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis.

MTA3 MTA2

1.37e-05922226028330
Pubmed

RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene.

MTA3 MTA2

1.37e-05922222926524
Pubmed

PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.

MTA3 MTA2

1.71e-051022234180153
Pubmed

Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development.

MTA3 MTA2

2.51e-051222220720167
Pubmed

NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.

MTA3 MTA2

2.51e-051222222560079
Pubmed

Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14.

MTA3 MTA2

2.51e-051222221937684
Pubmed

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer.

MTA3 MTA2

2.97e-051322219703393
Pubmed

The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.

MTA3 MTA2

2.97e-051322212920132
Pubmed

NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.

MTA3 MTA2

3.46e-051422225150861
Pubmed

MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

MTA3 MTA2

3.46e-051422216428440
Pubmed

NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development.

MTA3 MTA2

3.99e-051522219927129
Pubmed

The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.

MTA3 MTA2

3.99e-051522225247294
Pubmed

The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.

MTA3 MTA2

5.81e-05182229790534
Pubmed

Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development.

MTA3 MTA2

5.81e-051822223201013
Pubmed

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.

MTA3 MTA2

5.81e-051822210444591
Pubmed

FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis.

MTA3 MTA2

7.21e-052022227773593
Pubmed

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.

MTA3 MTA2

1.33e-042722223395962
Pubmed

PHD finger protein 1 (PHF1) is a novel reader for histone H4R3 symmetric dimethylation and coordinates with PRMT5-WDR77/CRL4B complex to promote tumorigenesis.

MTA3 MTA2

1.76e-043122229846670
Pubmed

Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

MTA3 MTA2

2.65e-043822233283408
Pubmed

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.

MTA3 MTA2

3.72e-044522221258344
Pubmed

The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.

MTA3 MTA2

4.78e-045122222770845
Pubmed

CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway.

MTA3 MTA2

5.16e-045322234026424
Pubmed

Analysis of the DNA sequence and duplication history of human chromosome 15.

GOLGA6L19 GOLGA6L10

5.76e-045622216572171
InteractionMBD3L2 interactions

MTA3 GOLGA6L9 MTA2

6.24e-0641183int:MBD3L2
InteractionSCT interactions

MEP1B VIPR1

2.70e-059182int:SCT
InteractionRHOBTB3 interactions

VIPR1 RTN4R IHO1

8.12e-0596183int:RHOBTB3
InteractionCGB2 interactions

MTA3 MTA2

1.14e-0418182int:CGB2
InteractionBOLA2 interactions

MTA2 GLRX3 IHO1

1.42e-04116183int:BOLA2
InteractionPOLR1C interactions

GOLGA6L9 FOXR2 FUCA2 IHO1

1.43e-04311184int:POLR1C
InteractionZFPM2 interactions

MTA3 MTA2

2.81e-0428182int:ZFPM2
InteractionZKSCAN3 interactions

GOLGA6L9 IHO1

2.81e-0428182int:ZKSCAN3
InteractionZNF827 interactions

MTA3 MTA2

3.02e-0429182int:ZNF827
InteractionTCF19 interactions

MTA3 MTA2

3.68e-0432182int:TCF19
Cytoband15q25.2

GOLGA6L9 GOLGA6L10

1.78e-044321215q25.2
CytobandEnsembl 112 genes in cytogenetic band chr15q25

GOLGA6L9 GOLGA6L10

2.43e-03160212chr15q25
GeneFamilyPHD finger proteins|NuRD complex

MTA3 MTA2

2.21e-05121121305
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

MTA3 MTA2

3.52e-051511282
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

MTA3 MTA2

4.56e-0453112532
ComputationalNeighborhood of TNFRSF25

SLC6A9 ADAMTSL2

2.68e-043092CAR_TNFRSF25
ComputationalNeighborhood of PTPN9

SLC6A9 ADAMTSL2

1.11e-036192MORF_PTPN9
ComputationalNeighborhood of RBM8A

SLC6A9 ADAMTSL2

2.15e-038592MORF_RBM8A
Drug6-methylenetestosterone acetate

MTA3 MTA2

1.21e-056212CID000159323
Diseasecreatinine measurement, glomerular filtration rate

RNF32-DT KBTBD2

2.04e-03117172EFO_0004518, EFO_0005208
Diseaseattention deficit hyperactivity disorder

MTA3 SLC6A9

1.73e-02354172EFO_0003888

Protein segments in the cluster

PeptideGeneStartEntry
MWLWQDIQCCPAPPS

ADAMTSL4-AS1

1

Q5T5F5
CVWMQARVSPAWPAG

RNF32-DT

196

Q8NI28
AQWYAWGPPNMQCRL

MTA2

376

O94776
VHFWAPWAPQCAQMN

GLRX3

36

O76003
LWQAQALPAAWNPGM

IHO1

296

Q8IYA8
MVSPLPCAWQWSAAV

KBTBD2

411

Q8IY47
RNPACGPQWEMSEWS

ADAMTSL2

681

Q86TH1
PVPQGAWMCGQAGWT

GOLGA6L9

376

A6NEM1
AWMCGQAGWTPQEHP

GOLGA6L9

381

A6NEM1
PVPQGAWMCGQAGWT

GOLGA6L10

466

A6NI86
AWMCGQAGWTPQEHP

GOLGA6L10

471

A6NI86
PQGAWMCGQAGWTPQ

GOLGA6L19

496

H0YKK7
PQLTIHQMPCKWGWA

FUCA2

446

Q9BTY2
LNVCNWAVMNWAPPG

GALNS

486

P34059
GNKSVWCQANNMWGP

CR2

126

P20023
WCQANNMWGPTRLPT

CR2

131

P20023
PNLWMWVDPNILCPL

FOXR2

76

Q6PJQ5
DQLQWPCPWQQATMT

MEP1B

486

Q16820
QSHQWYSWGPPNMQC

MTA3

386

Q9BTC8
LWLQAWQVAAPCPGA

RTN4R

16

Q9BZR6
MWDNLTCWPATPRGQ

VIPR1

66

P32241
MTHVLPWAYCNNPWN

SLC6A9

211

P48067
PVNWACPWCNAMNFP

TEX13C

956

A0A0J9YWL9
MWDQGGQPWQQWPLN

PNISR

1

Q8TF01
GQPWQQWPLNQQQWM

PNISR

6

Q8TF01
DPQMNPNGPAWCWWM

LONRF3

706

Q496Y0