Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF729 ZNF708 ZNF93 ZNF133 NRIP1 ZNF486 GZF1 ZNF493 ZC3H8 ZNF253 ZNF587 ZNF644 ZFP41 ZNF780B ZNF516 ZFP1 ZNF84 ZNF700 ZNF417 ZNF287 OVOL2

2.69e-0614599321GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF729 ZNF708 ZNF93 ZNF133 ZNF486 GZF1 ZNF493 ZC3H8 ZNF253 ZNF587 ZNF644 ZFP41 ZNF780B ZNF516 ZFP1 ZNF84 ZNF700 ZNF417 ZNF287 OVOL2

6.22e-0614129320GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF729 ZNF708 ZNF93 NRIP1 ZNF486 GZF1 ZNF493 ZNF253 ZNF587 ZNF644 ZNF780B ZNF516 ZFP1 ZNF84 ZNF417 ZNF287 OVOL2

5.45e-0512449317GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF729 ZNF708 ZNF93 NRIP1 ZNF486 GZF1 ZNF493 ZNF253 ZNF587 ZNF644 ZNF780B ZNF516 ZFP1 ZNF84 ZNF417 ZNF287 OVOL2

7.12e-0512719317GO:0000987
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate binding

RAG2 GBF1 HIP1R

4.00e-0431933GO:0080025
GeneOntologyMolecularFunctionmodification-dependent protein binding

JARID2 YEATS2 RAG2 ANK2 DAXX CDY1

4.05e-04206936GO:0140030
GeneOntologyCellularComponentsmooth endoplasmic reticulum

MYO1D PRDX4 CANX APOB

5.64e-0546954GO:0005790
DomainZnf_C2H2-like

ZNF729 ZNF708 ZNF93 ZNF133 ZNF346 ZNF800 ZNF486 GTF3A GZF1 ZNF493 ZNF253 ZNF587 ZNF706 ZNF644 ZFP41 ZNF780B ZNF516 ZFP1 ZNF84 ZNF700 ZNF417 REPIN1 ZNF287 ZNF222 OVOL2

9.54e-147969425IPR015880
DomainZnf_C2H2

ZNF729 ZNF708 ZNF93 ZNF133 ZNF346 ZNF800 ZNF486 GTF3A GZF1 ZNF493 ZNF253 ZNF587 ZNF706 ZNF644 ZFP41 ZNF780B ZNF516 ZFP1 ZNF84 ZNF700 ZNF417 REPIN1 ZNF287 ZNF222 OVOL2

1.23e-138059425IPR007087
DomainZnF_C2H2

ZNF729 ZNF708 ZNF93 ZNF133 ZNF346 ZNF800 ZNF486 GTF3A GZF1 ZNF493 ZNF253 ZNF587 ZNF706 ZNF644 ZFP41 ZNF780B ZNF516 ZFP1 ZNF84 ZNF700 ZNF417 REPIN1 ZNF287 ZNF222 OVOL2

1.33e-138089425SM00355
DomainZnf_C2H2/integrase_DNA-bd

ZNF729 ZNF708 ZNF93 ZNF133 ZNF800 ZNF486 GTF3A GZF1 ZNF493 ZNF253 ZNF587 ZNF644 ZFP41 ZNF780B ZNF516 ZFP1 ZNF84 ZNF700 ZNF417 REPIN1 ZNF287 ZNF222 OVOL2

3.72e-136949423IPR013087
DomainZINC_FINGER_C2H2_2

ZNF729 ZNF708 ZNF93 ZNF133 ZNF800 ZNF486 GTF3A GZF1 ZNF493 ZNF253 ZNF587 ZNF706 ZNF644 ZFP41 ZNF780B ZNF516 ZFP1 ZNF84 ZNF700 ZNF417 REPIN1 ZNF287 ZNF222 OVOL2

4.46e-137759424PS50157
DomainZINC_FINGER_C2H2_1

ZNF729 ZNF708 ZNF93 ZNF133 ZNF800 ZNF486 GTF3A GZF1 ZNF493 ZNF253 ZNF587 ZNF706 ZNF644 ZFP41 ZNF780B ZNF516 ZFP1 ZNF84 ZNF700 ZNF417 REPIN1 ZNF287 ZNF222 OVOL2

4.72e-137779424PS00028
Domain-

ZNF729 ZNF708 ZNF93 ZNF133 ZNF800 ZNF486 GTF3A GZF1 ZNF493 ZNF253 ZNF587 ZNF644 ZFP41 ZNF780B ZNF516 ZFP1 ZNF84 ZNF700 ZNF417 REPIN1 ZNF222 OVOL2

2.07e-1267994223.30.160.60
Domainzf-C2H2

ZNF729 ZNF708 ZNF93 ZNF133 ZNF486 GTF3A GZF1 ZNF493 ZNF253 ZNF587 ZNF644 ZFP41 ZNF780B ZNF516 ZFP1 ZNF84 ZNF700 ZNF417 REPIN1 ZNF287 ZNF222 OVOL2

3.10e-126939422PF00096
DomainKRAB

ZNF729 ZNF708 ZNF93 ZNF133 ZNF486 ZNF253 ZNF587 ZNF780B ZFP1 ZNF84 ZNF700 ZNF417 ZNF738 ZNF287 ZNF222

3.05e-103589415PS50805
DomainKRAB

ZNF729 ZNF708 ZNF93 ZNF133 ZNF486 ZNF253 ZNF587 ZNF780B ZFP1 ZNF84 ZNF700 ZNF417 ZNF738 ZNF287 ZNF222

3.05e-103589415PF01352
DomainKRAB

ZNF729 ZNF708 ZNF93 ZNF133 ZNF486 ZNF253 ZNF587 ZNF780B ZFP1 ZNF84 ZNF700 ZNF417 ZNF738 ZNF287 ZNF222

4.64e-103699415SM00349
DomainKRAB

ZNF729 ZNF708 ZNF93 ZNF133 ZNF486 ZNF253 ZNF587 ZNF780B ZFP1 ZNF84 ZNF700 ZNF417 ZNF738 ZNF287 ZNF222

4.81e-103709415IPR001909
Domainzf-C2H2_6

ZNF729 ZNF93 ZNF133 ZNF486 GZF1 ZNF493 ZNF253 ZNF587 ZNF780B ZNF84 ZNF700 ZNF417

5.76e-083149412PF13912
DomainChromo_dom_subgr

CDY2A CDY1

1.10e-0310942IPR017984
Domain-

GBF1 PSD4

2.52e-03159421.10.1000.11
DomainSec7

GBF1 PSD4

2.52e-0315942PF01369
DomainSec7_alpha_orthog

GBF1 PSD4

2.52e-0315942IPR023394
DomainSec7

GBF1 PSD4

2.87e-0316942SM00222
DomainSEC7

GBF1 PSD4

2.87e-0316942PS50190
DomainSec7_dom

GBF1 PSD4

2.87e-0316942IPR000904
DomainCrotonase_core_superfam

CDY2A CDY1

3.24e-0317942IPR001753
DomainECH_1

CDY2A CDY1

3.24e-0317942PF00378
DomainCH

GAS2L3 SYNE2 NAV2

4.30e-0365943SM00033
DomainCH

GAS2L3 SYNE2 NAV2

5.30e-0370943PF00307
Domain-

GAS2L3 SYNE2 NAV2

5.51e-03719431.10.418.10
Domainzf-CCHC

RBBP6 ZCCHC7

5.92e-0323942PF00098
DomainCH

GAS2L3 SYNE2 NAV2

5.95e-0373943PS50021
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF708 ZNF93 ZNF486 ZNF493 ZNF253 ZNF587 ZNF644 ZFP1 ZNF84 ZNF417 ZNF738

3.35e-12181961137372979
Pubmed

Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.

PTPRC SIRPB1 SIRPA

8.14e-08496332294445
Pubmed

Increased susceptibility to Salmonella infection in signal regulatory protein α-deficient mice.

RAG2 SIRPB1 SIRPA

8.14e-08496322851710
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

YEATS2 NRIP1 DDX31 ALMS1 MYO1D RBBP6 ZNF644 CANX ZNF516 DAXX UBN2 ZMYM6

8.39e-08588961238580884
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

YEATS2 ELOA MLH3 ZNF644 ZNF516 PDCD11 DAXX UBN2

1.99e-0722296837071664
Pubmed

Accelerated thymopoiesis and improved T-cell responses in HLA-A2/-DR2 transgenic BRGS-based human immune system mice.

RAG2 SIRPB1 SIRPA

2.03e-07596330888052
Pubmed

A human immune system mouse model with robust lymph node development.

RAG2 SIRPB1 SIRPA

2.03e-07596330065364
Pubmed

Frontline Science: Exhaustion and senescence marker profiles on human T cells in BRGSF-A2 humanized mice resemble those in human samples.

RAG2 SIRPB1 SIRPA

4.05e-07696331378988
Pubmed

Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo.

RAG2 SIRPB1 SIRPA

4.05e-07696321788504
Pubmed

CCR7 Modulates the Generation of Thymic Regulatory T Cells by Altering the Composition of the Thymic Dendritic Cell Compartment.

RAG2 SIRPB1 SIRPA

4.05e-07696328978470
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

CSDE1 WDR3 JARID2 ZNF346 ZNF800 DDX31 GZF1 TSR1 RBBP6 PRDX4 HIP1R PDCD11 DAXX RAB11FIP1 UBN2 REPIN1 ERLIN1

6.77e-071497961731527615
Pubmed

Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment.

RAG2 SIRPB1 SIRPA

7.08e-07796323293079
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

CSDE1 WDR3 ELOA GBF1 DDX31 GZF1 ANK2 GAS2L3 TSR1 PRDX4 KBTBD8 PDCD11 APOB HAL REPIN1 ERLIN1

1.06e-061371961636244648
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF729 JARID2 ZNF93 ZNF346 GTF3A ZC3H8 ZNF644 ZFP41 ZNF516 ASH1L PLXNA2 OVOL2

2.39e-06808961220412781
Pubmed

Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts.

RAG2 SIRPB1 SIRPA

2.41e-061096328783664
Pubmed

Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells.

RAG2 SIRPB1 SIRPA

2.41e-061096317982459
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

WDR3 ELOA ZNF800 GBF1 GZF1 WASHC4 RBBP6 ZNF644 CANX SIRPA ZCCHC7 ZNF417 REPIN1 ERLIN1

5.54e-061203961429180619
Pubmed

Proteasome-mediated degradation of apolipoprotein B targets both nascent peptides cotranslationally before translocation and full-length apolipoprotein B after translocation into the endoplasmic reticulum.

CANX APOB

7.54e-0629629765244
Pubmed

Frontline Science: Cxxc5 expression alters cell cycle and myeloid differentiation of mouse hematopoietic stem and progenitor cells.

TET2 RAG2

7.54e-06296232083332
Pubmed

Continuous Effector CD8(+) T Cell Production in a Controlled Persistent Infection Is Sustained by a Proliferative Intermediate Population.

RAG2 PTPRC

7.54e-06296227421704
Pubmed

FYN-TRAF3IP2 induces NF-κB signaling-driven peripheral T cell lymphoma.

TET2 RAG2

7.54e-06296233928261
Pubmed

A role for palmitoylation in the quality control, assembly and secretion of apolipoprotein B.

CANX APOB

7.54e-06296214498830
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

ZNF93 USP45 PTPRC GAS2L3 TSR1 KBTBD8 ASH1L APOB UBN2 GEN1 REPIN1 ERLIN1 STK25

8.99e-061084961311544199
Pubmed

Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.

ZNF729 ZNF93 ZNF493

9.05e-061596315885501
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

WDR19 TET2 WASHC4 TSR1 ZNF516 HIP1R NAV2 PDCD11 CEP126

1.63e-0552996914621295
Pubmed

SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.

SIRPB1 SIRPA

2.26e-05396236202053
Pubmed

Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the migration of Langerhans cells from the epidermis to draining lymph nodes.

SIRPB1 SIRPA

2.26e-05396215034021
Pubmed

Non-Hematopoietic and Hematopoietic SIRPα Signaling Differently Regulates Murine B Cell Maturation in Bone Marrow and Spleen.

SIRPB1 SIRPA

2.26e-05396226222253
Pubmed

B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.

RAG2 PTPRC

2.26e-05396210429672
Pubmed

Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1.

SIRPB1 SIRPA

2.26e-05396212167615
Pubmed

Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk.

SIRPB1 SIRPA

2.26e-05396231507080
Pubmed

Involvement of signal regulatory protein α, a negative regulator of Toll-like receptor signaling, in impairing the MyD88-independent pathway and intracellular killing of Burkholderia pseudomallei-infected mouse macrophages.

SIRPB1 SIRPA

2.26e-05396222988019
Pubmed

Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain.

SIRPB1 SIRPA

2.26e-05396222468987
Pubmed

Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha.

SIRPB1 SIRPA

2.26e-05396234917090
Pubmed

Effect of Serum Deprivation Stress on Signal Induction Regulatory Protein-Alpha (SIRP-Alpha)-Mediated Erythrophagocytosis by Macrophages.

SIRPB1 SIRPA

2.26e-05396230894504
Pubmed

Inhibitory regulation of osteoclast bone resorption by signal regulatory protein alpha.

SIRPB1 SIRPA

2.26e-05396219667119
Pubmed

Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease.

APOB ERLIN1

2.26e-05396232776921
Pubmed

SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors.

SIRPB1 SIRPA

2.26e-05396228669759
Pubmed

SIRPα controls the activity of the phagocyte NADPH oxidase by restricting the expression of gp91(phox).

SIRPB1 SIRPA

2.26e-05396223022485
Pubmed

Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.

SIRPB1 SIRPA

2.26e-05396229158380
Pubmed

Lack of non-hematopoietic SIRPα signaling disturbs the splenic marginal zone architecture resulting in accumulation and displacement of marginal zone B cells.

SIRPB1 SIRPA

2.26e-05396225817792
Pubmed

Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus.

SIRPB1 SIRPA

2.26e-05396212134038
Pubmed

The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development.

RAG2 PTPRC

2.26e-05396232610127
Pubmed

Central nervous system antigen P84 can serve as a substrate for neurite outgrowth.

SIRPB1 SIRPA

2.26e-0539622303162
Pubmed

SHPS-1 promotes the survival of circulating erythrocytes through inhibition of phagocytosis by splenic macrophages.

SIRPB1 SIRPA

2.26e-05396216141346
Pubmed

Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury.

SIRPB1 SIRPA

2.26e-05396231883525
Pubmed

Signal regulatory protein α is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression.

SIRPB1 SIRPA

2.26e-05396223504854
Pubmed

SIRPα signaling regulates podocyte structure and function.

SIRPB1 SIRPA

2.26e-05396223842779
Pubmed

Essential roles of SIRPα in homeostatic regulation of skin dendritic cells.

SIRPB1 SIRPA

2.26e-05396220955735
Pubmed

A role for SHPS-1/SIRPalpha in Concanavalin A-dependent production of MMP-9.

SIRPB1 SIRPA

2.26e-05396217825046
Pubmed

SIRPα deficiency accelerates the pathologic process in models of Parkinson disease.

SIRPB1 SIRPA

2.26e-05396231322787
Pubmed

Soluble SIRP-Alpha Promotes Murine Acute Lung Injury Through Suppressing Macrophage Phagocytosis.

SIRPB1 SIRPA

2.26e-05396235634325
Pubmed

The Rho kinase pathway regulates the migration of dendritic cells through SIRP-α.

SIRPB1 SIRPA

2.26e-05396222391241
Pubmed

The murine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein family.

SIRPB1 SIRPA

2.26e-0539629348339
Pubmed

Targeting SIRP-α protects from type 2-driven allergic airway inflammation.

SIRPB1 SIRPA

2.26e-05396221108471
Pubmed

Mutational analysis of the mechanism of negative regulation by SRC homology 2 domain-containing protein tyrosine phosphatase substrate-1 of phagocytosis in macrophages.

SIRPB1 SIRPA

2.26e-05396216920950
Pubmed

Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the induction of Langerhans cell maturation.

SIRPB1 SIRPA

2.26e-05396217109464
Pubmed

Signal regulatory protein α negatively regulates mast-cell activation following FcεRI aggregation.

SIRPB1 SIRPA

2.26e-05396223504624
Pubmed

Expression of recipient CD47 on rat insulinoma cell xenografts prevents macrophage-mediated rejection through SIRPα inhibitory signaling in mice.

SIRPB1 SIRPA

2.26e-05396223472187
Pubmed

SIRP/CD47 signaling in neurological disorders.

SIRPB1 SIRPA

2.26e-05396225795378
Pubmed

Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103(+) CD11b(+) DCs in the intestinal lamina propria.

SIRPB1 SIRPA

2.26e-05396225236797
Pubmed

Deficiency in SIRP-α cytoplasmic recruitment confers protection from acute kidney injury.

SIRPB1 SIRPA

2.26e-05396231370677
Pubmed

A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression.

SIRPB1 SIRPA

2.26e-05396230770827
Pubmed

Signal regulatory protein α protects podocytes through promoting autophagic activity.

SIRPB1 SIRPA

2.26e-05396230888336
Pubmed

Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses.

SIRPB1 SIRPA

2.26e-05396238758648
Pubmed

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration.

SIRPB1 SIRPA

2.26e-05396233795678
Pubmed

Requirement of SIRPα for protective immunity against Leishmania major.

SIRPB1 SIRPA

2.26e-05396220854790
Pubmed

Resistance to experimental autoimmune encephalomyelitis and impaired T cell priming by dendritic cells in Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 mutant mice.

SIRPB1 SIRPA

2.26e-05396217617577
Pubmed

BIT, an immune antigen receptor-like molecule in the brain.

SIRPB1 SIRPA

2.26e-0539629271230
Pubmed

Gene structure of mouse BIT/SHPS-1.

SIRPB1 SIRPA

2.26e-05396210585853
Pubmed

Diagnostic potential of zinc finger protein-specific autoantibodies and associated linear B-cell epitopes in colorectal cancer.

ZNF346 ZNF700

2.26e-05396225875936
Pubmed

Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes.

SIRPB1 SIRPA

2.26e-05396218635660
Pubmed

Tyrosine phosphorylation of the transmembrane protein SIRPα: Sensing synaptic activity and regulating ectodomain cleavage for synapse maturation.

SIRPB1 SIRPA

2.26e-05396229914984
Pubmed

SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility.

SIRPB1 SIRPA

2.26e-05396211118207
Pubmed

Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy.

SIRPB1 SIRPA

2.26e-05396234050181
Pubmed

DNA hypermethylation is associated with invasive phenotype of malignant melanoma.

TET2 NAV2

2.26e-05396231602702
Pubmed

Ectodomain shedding of SHPS-1 and its role in regulation of cell migration.

SIRPB1 SIRPA

2.26e-05396215123722
Pubmed

Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.

RAG2 SIRPA

2.26e-05396221788509
Pubmed

SIRPα+ dendritic cells promote the development of fibroblastic reticular cells in murine peripheral lymph nodes.

SIRPB1 SIRPA

2.26e-05396231099900
Pubmed

Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance.

SIRPB1 SIRPA

2.26e-05396233074246
Pubmed

Resistance to collagen-induced arthritis in SHPS-1 mutant mice.

SIRPB1 SIRPA

2.26e-05396218455510
Pubmed

Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling.

SIRPB1 SIRPA

2.26e-05396226057870
Pubmed

Essential roles of SHPS-1 in induction of contact hypersensitivity of skin.

SIRPB1 SIRPA

2.26e-05396218809435
Pubmed

Signal regulatory protein alpha (SIRPalpha)/CD47 interaction and function.

SIRPB1 SIRPA

2.26e-05396219223164
Pubmed

Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages.

SIRPB1 SIRPA

2.26e-05396218233962
Pubmed

Suppression of SHP-1 promotes corticospinal tract sprouting and functional recovery after brain injury.

SIRPB1 SIRPA

2.26e-05396223559001
Pubmed

SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress.

SIRPB1 SIRPA

2.26e-05396222671569
Pubmed

Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells.

SIRPB1 SIRPA

2.26e-05396235511221
Pubmed

Regulation by Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 of alpha-galactosylceramide-induced antimetastatic activity and Th1 and Th2 responses of NKT cells.

SIRPB1 SIRPA

2.26e-05396217475843
Pubmed

Focal cerebral ischemia upregulates SHP-1 in reactive astrocytes in juvenile mice.

SIRPB1 SIRPA

2.26e-05396212742627
Pubmed

Dendritic cell SIRPα regulates homeostasis of dendritic cells in lymphoid organs.

SIRPB1 SIRPA

2.26e-05396225818708
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

FSIP2 YEATS2 SYNE2 ASH1L CCDC168

2.41e-0512396526912792
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

TET2 FSIP2 KIAA0930 GBF1 DLC1 ALMS1 SYNE2 NAV2 STIL RAB11FIP1 GEN1

2.61e-05861961136931259
Pubmed

Human transcription factor protein interaction networks.

TET2 YEATS2 DDX31 ALMS1 MYO1D RBBP6 ZNF644 CANX SYNE2 ZNF516 PDCD11 HAL UBN2 FILIP1L

3.76e-051429961435140242
Pubmed

SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease.

SIRPB1 SIRPA

4.51e-05496235722884
Pubmed

Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.

SIRPB1 SIRPA

4.51e-05496222976304
Pubmed

Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways.

SIRPB1 SIRPA

4.51e-05496234097709
Pubmed

TLR5 mediates CD172α(+) intestinal lamina propria dendritic cell induction of Th17 cells.

SIRPB1 SIRPA

4.51e-05496226907705
Pubmed

Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma.

TET2 RAG2

4.51e-05496235443168
Pubmed

Down-regulation of platelet surface CD47 expression in Escherichia coli O157:H7 infection-induced thrombocytopenia.

SIRPB1 SIRPA

4.51e-05496219771158
InteractionDEF8 interactions

ALMS1 ZNF587 STIL ZNF417 ZMYM6

3.93e-0651945int:DEF8
InteractionANOS1 interactions

WDR3 ZNF708 ZNF346 ZNF800 DDX31 GZF1 PDCD11

4.78e-06143947int:ANOS1
Cytoband19p12

ZNF729 ZNF708 ZNF93 ZNF486 ZNF493 ZNF738

3.86e-089096619p12
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF729 ZNF708 ZNF93 ZNF486 ZNF493 ZNF738

2.37e-07122966chr19p12
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF729 ZNF708 ZNF93 ZNF133 ZNF800 ZNF486 GTF3A GZF1 ZNF493 ZNF253 ZNF587 ZFP41 ZNF780B ZNF516 ZFP1 ZNF84 ZNF700 ZNF417 REPIN1 ZNF287 ZNF222 OVOL2

1.60e-16718582228
GeneFamilyCD molecules|V-set domain containing|C1-set domain containing|Signal regulatory proteins

SIRPB1 SIRPA

1.01e-045582747
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

ZNF708 GBF1 PTPRC ZNF587 CANX ASH1L

3.13e-061869668571956890fc9894d766ba294a28e376b4aba428
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOA NRIP1 SYNE2 ASH1L APOB FILIP1L

3.65e-0619196660c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOA NRIP1 SYNE2 ASH1L APOB FILIP1L

3.65e-0619196609db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOA NRIP1 SYNE2 ASH1L APOB FILIP1L

3.65e-06191966973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBF1 ANK2 GPR158 ZNF516 SIRPA OVOL2

4.11e-06195966bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellLPS_only-Endothelial-Endothelial-FOXM1|LPS_only / Treatment groups by lineage, cell group, cell type

GAS2L3 ZNF587 NAV2 PALMD STIL GEN1

4.36e-06197966038fd92750257d43d5e980fd06d77742b543f11a
ToppCellASK454-Epithelial-Type_2|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

DACT1 ZNF133 KBTBD8 FAM217B NAV2

1.15e-05136965ff9a5e111993fdb3ac64c5ef269e3460ff994517
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

WDR3 JARID2 ELOA ZNF644 CCDC168

1.79e-05149965768877bade04ca0321593b8470b5011ad8270431
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_1|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

YEATS2 ZNF133 USP45 MLH3 DDX31

3.18e-0516896553a982869dbf14f6a948589be9f2f3df3b9a7e97
ToppCellCV-Mild-7|Mild / Virus stimulation, Condition and Cluster

TET2 USP45 PTPRC WASHC4 STIL

3.65e-05173965c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF800 SYNE2 ASH1L PALMD FILIP1L

4.19e-0517896501dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|368C / Donor, Lineage, Cell class and subclass (all cells)

GBF1 ALMS1 SIRPB1 SIRPA PSD4

4.19e-05178965536a601abcc60867949ea06e9aafb6c7b799b56b
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

ZNF708 GBF1 PTPRC ZNF587 CANX

5.03e-05185965a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GAS2L3 APOB SIRPB1 SIRPA ZNF222

5.29e-051879655917bdfe84cf5941e21b415aebbab3090cc5d576
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

PTPRC ZNF644 SYNE2 ASH1L CENATAC

5.43e-05188965ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DLC1 MYO1D NAV2 RAB11FIP1 MS4A10

5.70e-0519096530b50d183d7649146eb1e79b47ba897355f1998a
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JARID2 KIAA0930 PTPRC HIP1R FILIP1L

5.99e-051929652de242d81dc085ae734eb7d1f091af9a542e0866
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JARID2 KIAA0930 PTPRC HIP1R FILIP1L

5.99e-05192965ba2a683472a8b785dbf666dc6e94356d879486c3
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBF1 ANK2 ZNF516 SIRPA OVOL2

6.14e-05193965471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBF1 ANK2 ZNF516 SIRPA OVOL2

6.14e-05193965fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4|TCGA-Prostate / Sample_Type by Project: Shred V9

ZNF516 NAV2 CLMP SIRPA FILIP1L

6.45e-051959655562665dd3beb70e2358aa32611a337bef5731c1
ToppCellControl-Classical_Monocyte-cMono_2|Classical_Monocyte / Disease condition and Cell class

CSDE1 PTPRC WASHC4 CANX RAB11FIP1

6.77e-05197965eb7610c9496a95a5fd866e16abcbc39b83abe617
ToppCellIPF-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

DLC1 MYO1D SYNE2 NAV2 PALMD

6.93e-05198965b8bd1ba268480f54451648e01631b615a3401144
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

NRIP1 ZNF800 RBBP6 ZNF644 SYNE2

6.93e-0519896576d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

NRIP1 RBBP6 ZNF644 SYNE2 CEP126

7.10e-0519996561b1ed2db71b96157b92b7535d1955a4033098da
ToppCellLPS_anti-TNF-Endothelial-Endothelial-FOXM1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

GAS2L3 SYNE2 NAV2 STIL GEN1

7.10e-0519996598575fcce726589e93fbb4df1aab03e57cb56076
ToppCellLPS_IL1RA-Endothelial-Endothelial-FOXM1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

GAS2L3 SYNE2 NAV2 STIL GEN1

7.10e-05199965be2276c9a1994579ba1d2998b49bf549c1324d44
ToppCellSigmoid-T_cell-cycling_gd_T|T_cell / Region, Cell class and subclass

GBF1 ZNF253 STIL GEN1 ERLIN1

7.27e-052009654e489ecf472857357d45e9f6c7a812aa48b72ebf
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TET2 PTPRC ZNF644 SYNE2 ASH1L

7.27e-0520096512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellcontrol-Neutrophil|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TET2 KIAA0930 SIRPB1 SIRPA RAB11FIP1

7.27e-05200965b5d197472799cc61d7497faed91ac2564ae4930a
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-CPNs|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

DACT1 ANK2 CLMP PALMD PLXNA2

7.27e-0520096571cbefbef4ae5bbb5f6e419914f4b3b3b5a5f9e3
ToppCellcontrol-HLA-DR-_S100A+_Monocyte|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TET2 KIAA0930 SIRPB1 SIRPA RAB11FIP1

7.27e-052009659e3e13a68bc1110fa000ec2d80f4c654ddbce17e
Diseaselevel of tyrosine-protein phosphatase non-receptor type substrate 1 in blood serum

SIRPB1 SIRPA

9.41e-062912OBA_2040362
Diseaseretinal degeneration (implicated_via_orthology)

EYS PDE6C NDUFAF6

1.45e-0433913DOID:8466 (implicated_via_orthology)
Diseaselymphocyte count

TET2 JARID2 NRIP1 ZNF800 HTR1D GBF1 PTPRC ALMS1 MYO1D ZNF644 CANX ZFP1 NDUFAF6 PSD4

1.53e-0414649114EFO_0004587
Diseasesignal-regulatory protein beta-1 measurement

SIRPB1 SIRPA

3.34e-049912EFO_0802069
DiseaseN-acetylphenylalanine measurement

ALMS1 C2orf78

5.08e-0411912EFO_0800019
Diseasesevere combined immunodeficiency (is_implicated_in)

RAG2 PTPRC

8.36e-0414912DOID:627 (is_implicated_in)
Diseaseobsolete_red blood cell distribution width

NRIP1 ZNF800 GTF3A MYO1D GPR158 SYNE2 ZNF516 KBTBD8 HIP1R APOB CLMP SIRPA

8.78e-0413479112EFO_0005192
DiseaseSpermatogenic Failure, Nonobstructive, Y-Linked

CDY2A CDY1

1.10e-0316912C1839071
DiseaseSPERMATOGENIC FAILURE, Y-LINKED, 2

CDY2A CDY1

1.10e-0316912415000
DiseaseSpermatogenic failure, Y-linked, 2

CDY2A CDY1

1.10e-0316912cv:C1839071
DiseaseOmenn Syndrome

RAG2 PTPRC

1.55e-0319912C2700553
DiseaseSevere Combined Immunodeficiency

RAG2 PTPRC

1.72e-0320912C0085110
Diseaseresponse to antiviral drug, cirrhosis of liver

USP45 PLXNA2

2.48e-0324912EFO_0001422, EFO_0010123
Diseaseresponse to radiation

PTPRC NDUFAF6 CLMP

2.58e-0388913GO_0009314
Diseasecolon adenocarcinoma (is_marker_for)

TET2 DAXX

2.69e-0325912DOID:234 (is_marker_for)
Diseasenevus count, cutaneous melanoma

JARID2 KIAA0930 SYNE2

2.83e-0391913EFO_0000389, EFO_0004632

Protein segments in the cluster

PeptideGeneStartEntry
SEKPSHKSFATHKLS

ASH1L

796

Q9NR48
SKNSPKTPVTDKHHR

CDY1

91

Q9Y6F8
SKNSPKTPVTDKHHR

CDY2A

91

Q9Y6F7
SASVNKAKHSSNKPH

C2orf78

541

A6NCI8
KAKHSSNKPHKAASS

C2orf78

546

A6NCI8
AAHKYATSNKHKLTP

ERLIN1

266

O75477
LKHHNRIHTGSKPFK

GZF1

506

Q9H116
HKPKSHISNINVEAK

ALMS1

3001

Q8TCU4
KKLPKGTVSFHSHSD

CSDE1

411

O75534
AHSAKKKLNLAPAAT

DAXX

136

Q9UER7
KHNHVKLKPTIFSKD

RAG2

51

P55895
QDPSKHKTGLFEHKS

ANK2

2001

Q01484
HKSPHKNSISLKEQE

PALMD

496

Q9NP74
EKSKGSHTLFKLHPS

EYS

1726

Q5T1H1
ALKHKSSGKIFASEH

FSCB

181

Q5H9T9
TFSLKEKSHHKPKAA

GPR158

1041

Q5T848
KLPAKHTSHNKNDHL

MFI

106

Q8NCR3
HIHKKKSQQVFASPS

KIAA0930

131

Q6ICG6
HITAKSKYGFPNKHS

FSIP2

2951

Q5CZC0
PSHKKEHYLSSVNKT

PLXNA2

151

O75051
KHKKSFLEHSSLENP

MLH3

486

Q9UHC1
AAHTKKTHNVPDVKK

PDE6C

146

P51160
KTHNVPDVKKNSHFS

PDE6C

151

P51160
KHARSFHKTVPVKAF

NDUFAF6

271

Q330K2
ASKSGPSRKKAFHHE

FAM217B

241

Q9NTX9
ASKTQAHAHPRKKGK

FAM217B

341

Q9NTX9
LLAPHQHEKSQKKSS

MS4A10

41

Q96PG2
PHRSNSVADSKKKGH

NRIP1

951

P48552
LHVNSAHPGSSFLKK

OVOL2

231

Q9BRP0
PDLHKKTQSKHSLAE

DDX31

771

Q9H8H2
GTPRKAHSKSAKEHQ

RBBP6

1086

Q7Z6E9
AHSKSAKEHQETKPV

RBBP6

1091

Q7Z6E9
FDAAHKHSGKKQTVP

KBTBD8

291

Q8NFY9
SASVHLDSKKKQHLF

APOB

1466

P04114
SKVKANKHSPHLSRL

HIP1R

921

O75146
PTAFSLQFLHKKSTK

HAL

636

P42357
LHNHPAKTFVKIKAS

DACT1

801

Q9NYF0
SQNKEHKSSHKDKRP

ELOA

266

Q14241
SAQKKFPRHTKGHSF

FILIP1L

11

Q4L180
PSALSKNDHKHQKQL

CEP126

176

Q9P2H0
HQSPKSAFISAAKKA

FRMPD3

131

Q5JV73
SGKTQPKYLKHNHIS

GAS2L3

466

Q86XJ1
AKHHAISAKLNKPFL

CANX

126

P27824
HSAGSPLFFNHVKIK

HTR1D

266

P28221
HFKESGHNKLSSPKI

GEN1

831

Q17RS7
SNPKAHIAAKTVFHL

GBF1

1001

Q92538
EHLASPEHKKATNKF

CENATAC

91

Q86UT8
KVTDKPSHSHPFALK

ARRDC1-AS1

46

Q9H2J1
YLKAKKSPVLHTHSF

CCDC168

5161

Q8NDH2
KHKSASKPHHDDINF

CCDC168

6991

Q8NDH2
LVKDTKPNHHKPSSA

JARID2

356

Q92833
IHKPHLGKSSSLDKQ

RAB11FIP1

1051

Q6WKZ4
DHSLHLSKAKISKPA

PRDX4

71

Q13162
KHSEDQHPTILKKSS

SYNE2

4336

Q8WXH0
QAFGKKKSPKSASSH

NAV2

1841

Q8IVL1
KLSLKKSHSSPSLHQ

PSD4

1011

Q8NDX1
VSKSHDLKVSAHPKE

SIRPA

341

P78324
HVSSPKIHLQYAKAK

WDR19

891

Q8NEZ3
LKSSHHSKHKAPSKL

DLC1

676

Q96QB1
SKLHKGTALHSSQKP

STK25

331

O00506
FRHKPNLLSHSKIHK

REPIN1

301

Q9BWE0
SKSHDLKVSAHPKEQ

SIRPB1

341

Q5TFQ8
KKVHHANLTKAETTP

CLMP

346

Q9H6B4
KKHAFKISHPQIKTF

CNK3/IPCEF1

566

G9CGD6
VSQHSPSKKALYNKH

PDCD11

1356

Q14690
NKHSAPDSLKAKFSA

ZNF516

966

Q92618
SGKALSHKAAIFKHQ

ZFP1

161

Q6P2D0
SPTKVKKNAHNVDHA

STIL

1011

Q15468
AFNQSSSLTKHKKIH

ZNF93

461

P35789
SNTHKTRHTGKKPFK

ZNF738

191

Q8NE65
KSFQTHEKTHTGEKP

ZNF700

521

Q9H0M5
THHAFQPSKLKAIVA

USP19

561

O94966
SNLLKHQKTHTGEKP

ZFP41

156

Q8N8Y5
SVHNHLTSAPAKKKV

UBN2

666

Q6ZU65
SPLFSQHTAADKHKL

TSR1

626

Q2NL82
IHQPRAAKKHSSSKD

USP45

421

Q70EL2
PSLLKHQSTHAKEKS

ZNF287

381

Q9HBT7
FSTKHSVIPHQKLFT

ZNF587

221

Q96SQ5
FSTKHSVIPHQKLFT

ZNF417

221

Q8TAU3
QHQKTHSSAKPFVCK

ZNF780B

686

Q9Y6R6
PKTFKQHFESKHPKT

ZNF706

51

Q9Y5V0
FSKKPSLIKHQSRHI

ZNF84

216

P51523
FSLKKSLARHQKAHS

ZNF133

251

P52736
VAHAKNPTHSNKKLP

ZNF644

181

Q9H582
SNFTNHKKIHTGEKP

ZNF708

461

P17019
AFKQSSNLTTHKKIH

ZNF253

236

O75346
KAFKHPSHVTTHKKI

ZNF253

291

O75346
KPANLSHHLKTKHSE

ZMYM6

781

O95789
AHVSGFKHKNQSPKT

ZNF346

256

Q9UL40
FSLAKLKHPSASHIL

VN1R5

151

Q7Z5H4
KRLLKSVHHNPSKFG

WASHC4

221

Q2M389
FKTQKPSKPFHRSSH

ZCCHC7

486

Q8N3Z6
SNRHNTKHTGKKPFK

ZNF493

41

Q6ZR52
GKAFNHSSNLIKHKL

ZNF493

591

Q6ZR52
HKKTHKANASNSPEG

ZNF800

636

Q2TB10
KHFASPSKLKRHAKA

GTF3A

171

Q92664
TSAKIKSFDLIHSPH

WDR3

361

Q9UNX4
HAKSLFDHKALTLKS

TET2

1036

Q6N021
KAFNHPATLSSHKKI

ZNF486

301

Q96H40
KNSSEGNKHHKSTPL

PTPRC

1151

P08575
KNPRFHHLTPLKTKH

YEATS2

1211

Q9ULM3
KSFRHASSILNHKKL

ZNF222

376

Q9UK12
FNNSSTLKKHKLIHT

ZNF729

1001

A6NN14
KKFRHSAISPKSSLH

ZC3H8

51

Q8N5P1
NSKLGKHAHFSSRKL

MYO1D

476

O94832