Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionI-SMAD binding

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.88e-1417246GO:0070411
GeneOntologyMolecularFunctionSMAD binding

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

6.76e-1086246GO:0046332
GeneOntologyMolecularFunctionDEAD/H-box RNA helicase binding

SMAD1 SMAD3 SMAD5

1.28e-079243GO:0017151
GeneOntologyMolecularFunctionco-SMAD binding

SMAD1 SMAD2 SMAD3

3.33e-0712243GO:0070410
GeneOntologyMolecularFunctionR-SMAD binding

SMAD2 SMAD3 SMAD4

3.90e-0626243GO:0070412
GeneOntologyMolecularFunctionubiquitin protein ligase binding

SHPRH SMAD1 SMAD2 SMAD3 SMAD5

4.34e-05337245GO:0031625
GeneOntologyMolecularFunctionubiquitin-like protein ligase binding

SHPRH SMAD1 SMAD2 SMAD3 SMAD5

5.78e-05358245GO:0044389
GeneOntologyMolecularFunctionCCR6 chemokine receptor binding

DEFB130B DEFB130A

1.07e-0413242GO:0031731
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

SHPRH SUPV3L1 CHD6

4.61e-04127243GO:0008094
GeneOntologyMolecularFunctioncytokine receptor binding

DEFB130B SMAD2 DEFB130A SMAD3

5.59e-04324244GO:0005126
GeneOntologyMolecularFunctiontranscription coregulator binding

CHD6 SMAD3 SMAD4

6.13e-04140243GO:0001221
GeneOntologyMolecularFunctiontransforming growth factor beta receptor binding

SMAD2 SMAD3

6.30e-0431242GO:0005160
GeneOntologyMolecularFunctionhelicase activity

SHPRH SUPV3L1 CHD6

8.71e-04158243GO:0004386
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

SHPRH CHD6

8.99e-0437242GO:0140658
GeneOntologyMolecularFunctionneuropeptide binding

MRGPRX2 MRGPRX4

8.99e-0437242GO:0042923
GeneOntologyMolecularFunctionneuropeptide receptor activity

MRGPRX2 MRGPRX4

1.84e-0353242GO:0008188
GeneOntologyMolecularFunctionchemoattractant activity

DEFB130B DEFB130A

1.91e-0354242GO:0042056
GeneOntologyMolecularFunctiontranscription coactivator binding

SMAD3 SMAD4

1.91e-0354242GO:0001223
GeneOntologyMolecularFunctionCCR chemokine receptor binding

DEFB130B DEFB130A

2.05e-0356242GO:0048020
GeneOntologyMolecularFunctiontranscription corepressor binding

SMAD3 SMAD4

2.27e-0359242GO:0001222
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

2.94e-031244246GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

3.27e-031271246GO:0000987
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

SHPRH SUPV3L1 CHD6

3.69e-03262243GO:0140097
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

SMAD1 SMAD2 SMAD3 SMAD4

4.16e-03560244GO:0001228
GeneOntologyMolecularFunctioncollagen binding

SMAD3 SMAD4

4.23e-0381242GO:0005518
GeneOntologyMolecularFunctionchemokine receptor binding

DEFB130B DEFB130A

4.23e-0381242GO:0042379
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

SMAD1 SMAD2 SMAD3 SMAD4

4.32e-03566244GO:0001216
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

5.51e-031412246GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

6.46e-031459246GO:0000977
GeneOntologyMolecularFunctionG protein-coupled receptor binding

DEFB130B DEFB130A ARRDC3

7.41e-03337243GO:0001664
GeneOntologyMolecularFunctionchromatin binding

CHD6 SMAD2 SMAD3 SMAD4

1.10e-02739244GO:0003682
GeneOntologyMolecularFunctionG protein-coupled peptide receptor activity

MRGPRX2 MRGPRX4

1.10e-02133242GO:0008528
GeneOntologyMolecularFunctiontranscription factor binding

CHD6 SMAD2 SMAD3 SMAD4

1.17e-02753244GO:0008134
GeneOntologyMolecularFunctionpeptide receptor activity

MRGPRX2 MRGPRX4

1.22e-02140242GO:0001653
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

SMAD2 SMAD3 SMAD4

1.32e-02417243GO:0061629
GeneOntologyBiologicalProcessembryonic pattern specification

LAMA5 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

7.88e-1091246GO:0009880
GeneOntologyBiologicalProcessureteric bud development

LAMA5 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

2.11e-09107246GO:0001657
GeneOntologyBiologicalProcessSMAD protein signal transduction

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

2.50e-09110246GO:0060395
GeneOntologyBiologicalProcessmesonephric tubule development

LAMA5 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

2.50e-09110246GO:0072164
GeneOntologyBiologicalProcessmesonephric epithelium development

LAMA5 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

2.50e-09110246GO:0072163
GeneOntologyBiologicalProcessmesonephros development

LAMA5 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

2.94e-09113246GO:0001823
GeneOntologyBiologicalProcesskidney epithelium development

LAMA5 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

2.56e-08162246GO:0072073
GeneOntologyBiologicalProcesstransforming growth factor beta receptor signaling pathway

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

5.98e-07276246GO:0007179
GeneOntologyBiologicalProcessprimary miRNA processing

SMAD1 SMAD2 SMAD3

1.56e-0620243GO:0031053
GeneOntologyBiologicalProcesscellular response to transforming growth factor beta stimulus

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.88e-06336246GO:0071560
GeneOntologyBiologicalProcessconnective tissue development

SMAD1 SMAD3 ARRDC3 SMAD5 SMAD9 LARGE1

2.12e-06343246GO:0061448
GeneOntologyBiologicalProcessresponse to transforming growth factor beta

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

2.12e-06343246GO:0071559
GeneOntologyBiologicalProcessBMP signaling pathway

SMAD1 SMAD2 SMAD4 SMAD5 SMAD9

2.77e-06197245GO:0030509
GeneOntologyBiologicalProcesskidney development

LAMA5 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

3.38e-06372246GO:0001822
GeneOntologyBiologicalProcessrenal system development

LAMA5 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

4.18e-06386246GO:0072001
GeneOntologyBiologicalProcessresponse to BMP

SMAD1 SMAD2 SMAD4 SMAD5 SMAD9

4.25e-06215245GO:0071772
GeneOntologyBiologicalProcesscellular response to BMP stimulus

SMAD1 SMAD2 SMAD4 SMAD5 SMAD9

4.25e-06215245GO:0071773
GeneOntologyBiologicalProcessskeletal system development

LAMA5 SMAD1 SMAD2 SMAD3 SMAD5 SMAD9 LARGE1

4.50e-06615247GO:0001501
GeneOntologyBiologicalProcessadrenal gland development

SMAD2 SMAD3 SMAD4

4.96e-0629243GO:0030325
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

9.44e-06445246GO:0141091
GeneOntologyBiologicalProcessresponse to chloroquine

MRGPRX2 MRGPRX4

1.29e-055242GO:1902349
GeneOntologyBiologicalProcessMullerian duct regression

SMAD5 SMAD9

1.29e-055242GO:0001880
GeneOntologyBiologicalProcesscardiac conduction system development

SMAD1 SMAD4 SMAD5

1.33e-0540243GO:0003161
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.49e-05482246GO:0007178
GeneOntologyBiologicalProcesscardiac muscle hypertrophy in response to stress

SMAD1 SMAD3 SMAD4

1.54e-0542243GO:0014898
GeneOntologyBiologicalProcessmuscle hypertrophy in response to stress

SMAD1 SMAD3 SMAD4

1.54e-0542243GO:0003299
GeneOntologyBiologicalProcesscardiac muscle adaptation

SMAD1 SMAD3 SMAD4

1.66e-0543243GO:0014887
GeneOntologyBiologicalProcessosteoblast fate commitment

SMAD1 SMAD5

1.94e-056242GO:0002051
GeneOntologyBiologicalProcessmiRNA processing

SMAD1 SMAD2 SMAD3

2.31e-0548243GO:0035196
GeneOntologyBiologicalProcesspattern specification process

LAMA5 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

2.43e-05526246GO:0007389
GeneOntologyBiologicalProcessmesoderm development

SMAD1 SMAD2 SMAD3 SMAD4

3.05e-05157244GO:0007498
GeneOntologyBiologicalProcessregulation of transforming growth factor beta2 production

SMAD3 SMAD4

3.62e-058242GO:0032909
GeneOntologyBiologicalProcesstransforming growth factor beta2 production

SMAD3 SMAD4

3.62e-058242GO:0032906
GeneOntologyBiologicalProcessstriated muscle tissue development

SMAD1 SMAD3 SMAD4 SMAD5 LARGE1

4.40e-05349245GO:0014706
GeneOntologyBiologicalProcessactivin receptor signaling pathway

SMAD2 SMAD3 SMAD4

4.53e-0560243GO:0032924
GeneOntologyBiologicalProcesspositive regulation of miRNA transcription

SMAD1 SMAD3 SMAD4

4.77e-0561243GO:1902895
GeneOntologyBiologicalProcesspositive regulation of epithelial to mesenchymal transition

SMAD2 SMAD3 SMAD4

5.25e-0563243GO:0010718
GeneOntologyBiologicalProcessmesenchyme morphogenesis

SMAD2 SMAD3 SMAD4

5.77e-0565243GO:0072132
GeneOntologyBiologicalProcessembryonic foregut morphogenesis

SMAD2 SMAD3

7.09e-0511242GO:0048617
GeneOntologyBiologicalProcesspositive regulation of miRNA metabolic process

SMAD1 SMAD3 SMAD4

8.16e-0573243GO:2000630
GeneOntologyBiologicalProcessstriated muscle adaptation

SMAD1 SMAD3 SMAD4

8.16e-0573243GO:0014888
GeneOntologyBiologicalProcessregulatory ncRNA processing

SMAD1 SMAD2 SMAD3

8.50e-0574243GO:0070918
GeneOntologyBiologicalProcessforegut morphogenesis

SMAD2 SMAD3

8.50e-0512242GO:0007440
GeneOntologyBiologicalProcesspositive chemotaxis

DEFB130B DEFB130A SMAD3

8.85e-0575243GO:0050918
GeneOntologyBiologicalProcessgastrulation

SMAD1 SMAD2 SMAD3 SMAD4

9.81e-05212244GO:0007369
GeneOntologyBiologicalProcessparaxial mesoderm morphogenesis

SMAD2 SMAD3

1.00e-0413242GO:0048340
GeneOntologyBiologicalProcessmesoderm formation

SMAD1 SMAD2 SMAD3

1.15e-0482243GO:0001707
GeneOntologyBiologicalProcessregulation of miRNA transcription

SMAD1 SMAD3 SMAD4

1.20e-0483243GO:1902893
GeneOntologyBiologicalProcessmiRNA transcription

SMAD1 SMAD3 SMAD4

1.24e-0484243GO:0061614
GeneOntologyBiologicalProcessmesoderm morphogenesis

SMAD1 SMAD2 SMAD3

1.33e-0486243GO:0048332
GeneOntologyBiologicalProcesspositive regulation of extracellular matrix assembly

SMAD3 SMAD4

1.35e-0415242GO:1901203
GeneOntologyBiologicalProcessendoderm development

SMAD2 SMAD3 SMAD4

1.42e-0488243GO:0007492
GeneOntologyBiologicalProcesscartilage development

SMAD1 SMAD3 SMAD5 SMAD9

1.66e-04243244GO:0051216
GeneOntologyBiologicalProcesstissue morphogenesis

LAMA5 SMAD1 SMAD2 MST1L SMAD3 SMAD4

1.74e-04750246GO:0048729
GeneOntologyBiologicalProcessheart development

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 LARGE1

1.83e-04757246GO:0007507
GeneOntologyBiologicalProcesstube morphogenesis

LAMA5 SMAD1 SMAD2 MST1L SMAD3 SMAD4 SMAD5

2.15e-041125247GO:0035239
GeneOntologyBiologicalProcessregulation of miRNA metabolic process

SMAD1 SMAD3 SMAD4

2.27e-04103243GO:2000628
GeneOntologyBiologicalProcessbone development

SMAD1 SMAD5 SMAD9 LARGE1

2.28e-04264244GO:0060348
GeneOntologyBiologicalProcessanatomical structure regression

SMAD5 SMAD9

2.43e-0420242GO:0060033
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

3.42e-04850246GO:0071363
GeneOntologyBiologicalProcessmiRNA metabolic process

SMAD1 SMAD3 SMAD4

3.47e-04119243GO:0010586
GeneOntologyBiologicalProcessmesenchymal cell differentiation

LAMA5 SMAD2 SMAD3 SMAD4

3.52e-04296244GO:0048762
GeneOntologyBiologicalProcessparaxial mesoderm development

SMAD2 SMAD3

3.53e-0424242GO:0048339
GeneOntologyBiologicalProcessmuscle system process

SMAD1 SMAD3 SMAD4 SMAD5 LARGE1

3.60e-04547245GO:0003012
GeneOntologyBiologicalProcessosteoblast differentiation

SMAD1 SMAD3 SMAD4 SMAD5

3.80e-04302244GO:0001649
GeneOntologyBiologicalProcessgrowth

SUPV3L1 SMAD1 SMAD2 MST1L SMAD3 SMAD4 LARGE1

3.81e-041235247GO:0040007
GeneOntologyBiologicalProcesssegmentation

LAMA5 SMAD3 SMAD4

3.82e-04123243GO:0035282
GeneOntologyBiologicalProcessformation of primary germ layer

SMAD1 SMAD2 SMAD3

3.91e-04124243GO:0001704
GeneOntologyBiologicalProcessmuscle tissue development

SMAD1 SMAD3 SMAD4 SMAD5 LARGE1

3.95e-04558245GO:0060537
GeneOntologyBiologicalProcessgland development

LAMA5 SMAD2 MST1L SMAD3 SMAD4

3.95e-04558245GO:0048732
GeneOntologyBiologicalProcessnodal signaling pathway

SMAD2 SMAD3

4.15e-0426242GO:0038092
GeneOntologyBiologicalProcessresponse to growth factor

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

4.20e-04883246GO:0070848
GeneOntologyBiologicalProcesssecondary palate development

SMAD2 SMAD4

4.47e-0427242GO:0062009
GeneOntologyBiologicalProcessregulation of epithelial to mesenchymal transition

SMAD2 SMAD3 SMAD4

4.49e-04130243GO:0010717
GeneOntologyBiologicalProcesspericardium development

SMAD2 SMAD3

4.81e-0428242GO:0060039
GeneOntologyBiologicalProcesssignal transduction involved in regulation of gene expression

SMAD2 SMAD3

4.81e-0428242GO:0023019
GeneOntologyBiologicalProcessdevelopmental growth

SMAD1 SMAD2 MST1L SMAD3 SMAD4 LARGE1

4.96e-04911246GO:0048589
GeneOntologyBiologicalProcesscardiac muscle tissue development

SMAD1 SMAD4 SMAD5 LARGE1

5.13e-04327244GO:0048738
GeneOntologyBiologicalProcessregulation of extracellular matrix assembly

SMAD3 SMAD4

5.17e-0429242GO:1901201
GeneOntologyBiologicalProcesscell fate commitment

SMAD1 SMAD2 SMAD4 SMAD5

5.81e-04338244GO:0045165
GeneOntologyBiologicalProcesscardiac muscle hypertrophy

SMAD1 SMAD3 SMAD4

5.82e-04142243GO:0003300
GeneOntologyBiologicalProcesschemosensory behavior

MRGPRX2 MRGPRX4

5.91e-0431242GO:0007635
GeneOntologyBiologicalProcessstriated muscle hypertrophy

SMAD1 SMAD3 SMAD4

6.31e-04146243GO:0014897
GeneOntologyBiologicalProcessmuscle hypertrophy

SMAD1 SMAD3 SMAD4

6.56e-04148243GO:0014896
GeneOntologyBiologicalProcesspositive regulation of extracellular matrix organization

SMAD3 SMAD4

7.12e-0434242GO:1903055
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

CHD6 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

7.77e-041390247GO:0045944
GeneOntologyBiologicalProcesspositive regulation of cartilage development

SMAD1 SMAD3

7.98e-0436242GO:0061036
GeneOntologyBiologicalProcesstube development

LAMA5 SMAD1 SMAD2 MST1L SMAD3 SMAD4 SMAD5

8.18e-041402247GO:0035295
GeneOntologyBiologicalProcessmesenchyme development

LAMA5 SMAD2 SMAD3 SMAD4

8.31e-04372244GO:0060485
GeneOntologyBiologicalProcessendocrine system development

SMAD2 SMAD3 SMAD4

8.38e-04161243GO:0035270
GeneOntologyBiologicalProcessregulation of transforming growth factor beta production

SMAD3 SMAD4

8.43e-0437242GO:0071634
GeneOntologyBiologicalProcessmuscle adaptation

SMAD1 SMAD3 SMAD4

8.84e-04164243GO:0043500
GeneOntologyBiologicalProcesstransforming growth factor beta production

SMAD3 SMAD4

9.85e-0440242GO:0071604
GeneOntologyBiologicalProcessresponse to organic cyclic compound

MRGPRX2 MRGPRX4 SMAD1 SMAD2 SMAD5 SMAD9

1.04e-031048246GO:0014070
GeneOntologyBiologicalProcessregulation of binding

SMAD2 SMAD3 SMAD4 LARGE1

1.05e-03396244GO:0051098
GeneOntologyBiologicalProcessepithelium development

LAMA5 SMAD1 SMAD2 MST1L SMAD3 SMAD4 SMAD5

1.08e-031469247GO:0060429
GeneOntologyCellularComponentheteromeric SMAD protein complex

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

3.25e-178246GO:0071144
GeneOntologyCellularComponentSMAD protein complex

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

2.43e-1610246GO:0071141
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

5.08e-07272246GO:0090575
GeneOntologyCellularComponenthomomeric SMAD protein complex

SMAD1 SMAD2

1.26e-062242GO:0071142
GeneOntologyCellularComponentactivin responsive factor complex

SMAD2 SMAD4

3.79e-063242GO:0032444
GeneOntologyCellularComponenttranscription regulator complex

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

4.55e-05596246GO:0005667
GeneOntologyCellularComponentchromatin

SHPRH CHD6 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.63e-041480248GO:0000785
GeneOntologyCellularComponentneuronal cell body membrane

MRGPRX2 MRGPRX4

1.11e-0343242GO:0032809
GeneOntologyCellularComponentcell body membrane

MRGPRX2 MRGPRX4

1.32e-0347242GO:0044298
GeneOntologyCellularComponentnuclear inner membrane

SMAD1 SMAD3

2.08e-0359242GO:0005637
GeneOntologyCellularComponentnuclear protein-containing complex

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

3.89e-031377246GO:0140513
GeneOntologyCellularComponentneuromuscular junction

LAMA5 LARGE1

7.27e-03112242GO:0031594
HumanPhenoMucoid extracellular matrix accumulation

SMAD2 SMAD3 SMAD4

3.64e-061993HP:0200146
HumanPhenoMedial degeneration

SMAD2 SMAD3 SMAD4

3.64e-061993HP:0032079
HumanPhenoCystic medial necrosis

SMAD2 SMAD3 SMAD4

3.64e-061993HP:0012180
HumanPhenoDescending thoracic aorta aneurysm

SMAD2 SMAD3 SMAD4

3.64e-061993HP:0004959
HumanPhenoParoxysmal dyspnea

SMAD2 SMAD3 SMAD4

4.28e-062093HP:0012763
HumanPhenoDescending aortic dissection

SMAD2 SMAD3 SMAD4

4.99e-062193HP:0012499
HumanPhenoDural ectasia

SMAD2 SMAD3 SMAD4

7.58e-062493HP:0100775
HumanPhenoCarotid artery dilatation

SMAD2 SMAD3 SMAD4

7.58e-062493HP:0012163
HumanPhenoChronic fatigue

SMAD2 SMAD3 SMAD4

8.61e-062593HP:0012432
HumanPhenoAbnormal spinal meningeal morphology

SMAD2 SMAD3 SMAD4

8.61e-062593HP:0010303
HumanPhenoAscending aortic dissection

SMAD2 SMAD3 SMAD4

9.72e-062693HP:0004933
HumanPhenoAbnormal ascending aorta morphology

SMAD2 SMAD3 SMAD4

1.09e-052793HP:0031784
HumanPhenoAbnormal subarachnoid space morphology

MTRR SMAD2 SMAD3 SMAD4

1.39e-059694HP:0012703
HumanPhenoAbnormality of blood volume homeostasis

SMAD2 SMAD3 SMAD4

1.84e-053293HP:0011104
HumanPhenoHypovolemia

SMAD2 SMAD3 SMAD4

1.84e-053293HP:0011106
HumanPhenoPeripheral arterial stenosis

SMAD2 SMAD3 SMAD4

2.03e-053393HP:0004950
HumanPhenoIschemic stroke

SMAD2 SMAD3 SMAD4

3.12e-053893HP:0002140
HumanPhenoCerebral infarct

SMAD2 SMAD3 SMAD4

3.38e-053993HP:0025722
HumanPhenoSubarachnoid hemorrhage

SMAD2 SMAD3 SMAD4

3.38e-053993HP:0002138
HumanPhenoAortic dissection

SMAD2 SMAD3 SMAD4

3.65e-054093HP:0002647
HumanPhenoIntervertebral disk degeneration

SMAD2 SMAD3

4.15e-05692HP:0008419
HumanPhenoOsteochondritis dissecans

SMAD2 SMAD3

5.80e-05792HP:0010886
HumanPhenoDilatation of the cerebral artery

SMAD2 SMAD3 SMAD4

7.61e-055193HP:0004944
HumanPhenoAortic tortuosity

SMAD2 SMAD3

7.73e-05892HP:0006687
HumanPhenoHigh, narrow palate

CHD6 SMAD2 SMAD3 SMAD4

9.46e-0515694HP:0002705
HumanPhenoUterine rupture

SMAD2 SMAD3

9.93e-05992HP:0100718
HumanPhenoBifid uvula

SMAD2 SMAD3 SMAD4 LARGE1

1.23e-0416794HP:0000193
HumanPhenoTransient ischemic attack

SMAD2 SMAD3 SMAD4

1.30e-046193HP:0002326
HumanPhenoAbnormal spinal cord morphology

MTRR SMAD2 SMAD3 SMAD4 LARGE1

1.64e-0435795HP:0002143
HumanPhenoArterial dissection

SMAD2 SMAD3

1.81e-041292HP:0005294
HumanPhenoOsteochondrosis

SMAD2 SMAD3

1.81e-041292HP:0040188
HumanPhenoAortic root aneurysm

SMAD2 SMAD3 SMAD4

1.97e-047093HP:0002616
HumanPhenoCutis marmorata

SMAD2 SMAD3 SMAD4

2.14e-047293HP:0000965
HumanPhenoAbnormal uvula morphology

SMAD2 SMAD3 SMAD4 LARGE1

2.35e-0419794HP:0000172
HumanPhenoNarrow palate

CHD6 SMAD2 SMAD3 SMAD4

2.59e-0420294HP:0000189
HumanPhenoPneumothorax

SMAD2 SMAD3 SMAD4

2.61e-047793HP:0002107
HumanPhenoKnee osteoarthritis

SMAD2 SMAD3

2.88e-041592HP:0005086
HumanPhenoSpontaneous pneumothorax

SMAD2 SMAD3

3.29e-041692HP:0002108
HumanPhenoDilatation of the ascending aorta

SMAD2 SMAD3 SMAD4

3.38e-048493HP:0005111
HumanPhenoHemoptysis

SMAD2 SMAD3 SMAD4

3.88e-048893HP:0002105
HumanPhenoHip osteoarthritis

SMAD2 SMAD3

4.18e-041892HP:0008843
HumanPhenoAbnormal carotid artery morphology

SMAD2 SMAD3 SMAD4

4.43e-049293HP:0005344
HumanPhenoCleft soft palate

SMAD2 SMAD3 SMAD4 LARGE1

4.86e-0423894HP:0000185
HumanPhenoMalar flattening

CHD6 SMAD2 SMAD3 SMAD4

5.02e-0424094HP:0000272
HumanPhenoCleft secondary palate

SMAD2 SMAD3 SMAD4 LARGE1

5.02e-0424094HP:0410004
HumanPhenoAbnormal malar bone morphology

CHD6 SMAD2 SMAD3 SMAD4

5.78e-0424994HP:0012369
HumanPhenoAbnormal zygomatic arch morphology

CHD6 SMAD2 SMAD3 SMAD4

5.87e-0425094HP:0005557
HumanPhenoAbnormal zygomatic bone morphology

CHD6 SMAD2 SMAD3 SMAD4

5.87e-0425094HP:0010668
HumanPhenoCerebral hemorrhage

SMAD2 SMAD3 SMAD4

6.17e-0410393HP:0001342
HumanPhenoAortic regurgitation

SMAD2 SMAD3 SMAD4

6.17e-0410393HP:0001659
HumanPhenoDermal atrophy

CHD6 SMAD2 SMAD3

6.90e-0410793HP:0004334
HumanPhenoBicuspid aortic valve

SMAD2 SMAD3 SMAD4

9.42e-0411993HP:0001647
HumanPhenoDermal translucency

SMAD2 SMAD3

9.52e-042792HP:0010648
HumanPhenoAbnormal aortic valve cusp morphology

SMAD2 SMAD3 SMAD4

9.89e-0412193HP:0031567
HumanPhenoThoracic aortic aneurysm

SMAD2 SMAD3 SMAD4

9.89e-0412193HP:0012727
HumanPhenoAbnormal soft palate morphology

SMAD2 SMAD3 SMAD4 LARGE1

1.02e-0328994HP:0100736
HumanPhenoCerebral ischemia

SMAD2 SMAD3 SMAD4

1.04e-0312393HP:0002637
HumanPhenoTissue ischemia

SMAD2 SMAD3 SMAD4

1.04e-0312393HP:0033401
HumanPhenoAbdominal aortic aneurysm

SMAD2 SMAD3 SMAD4

1.09e-0312593HP:0005112
HumanPhenoArterial tortuosity

SMAD2 SMAD3

1.26e-033192HP:0005116
HumanPhenoHypoplastic iliac wing

LAMA5 SMAD4

1.26e-033192HP:0002866
HumanPhenoArachnodactyly

SMAD2 SMAD3 SMAD4

1.30e-0313393HP:0001166
HumanPhenoCardiomegaly

SMAD2 SMAD3 SMAD4

1.30e-0313393HP:0001640
HumanPhenoVaricose veins

SMAD2 SMAD3

1.34e-033292HP:0002619
HumanPhenoAbnormal sputum

SMAD2 SMAD3 SMAD4

1.39e-0313693HP:0032016
HumanPhenoChest pain

SMAD2 SMAD3 SMAD4

1.42e-0313793HP:0100749
HumanPhenoPulmonic stenosis

SMAD2 SMAD3 SMAD4

1.45e-0313893HP:0001642
HumanPhenoAbnormal meningeal morphology

SMAD2 SMAD3 SMAD4 LARGE1

1.57e-0332494HP:0010651
HumanPhenoVascular tortuosity

SMAD2 SMAD3

1.60e-033592HP:0004948
HumanPhenoHypoplastic facial bones

CHD6 SMAD2 SMAD3 SMAD4

1.70e-0333194HP:0002692
HumanPhenoAplasia/Hypoplasia of facial bones

CHD6 SMAD2 SMAD3 SMAD4

1.72e-0333294HP:0034261
HumanPhenoExertional dyspnea

SMAD2 SMAD3 SMAD4

1.74e-0314793HP:0002875
HumanPhenoStriae distensae

SMAD2 SMAD3

1.89e-033892HP:0001065
HumanPhenoMigraine

SMAD2 SMAD3 SMAD4

1.99e-0315493HP:0002076
HumanPhenoAbnormal left ventricular function

SMAD2 SMAD3 SMAD4

2.03e-0315593HP:0005162
HumanPhenoAbnormal vascular physiology

SMAD2 SMAD3 SMAD4 SMAD9

2.05e-0334894HP:0030163
HumanPhenoIntracranial hemorrhage

SMAD2 SMAD3 SMAD4

2.07e-0315693HP:0002170
HumanPhenoVenous insufficiency

SMAD2 SMAD3

2.09e-034092HP:0005293
HumanPhenoSlender finger

SMAD2 SMAD3 SMAD4

2.18e-0315993HP:0001238
HumanPhenoDisproportionate tall stature

SMAD2 SMAD3

2.20e-034192HP:0001519
HumanPhenoAbnormal pulmonary valve physiology

SMAD2 SMAD3 SMAD4

2.34e-0316393HP:0031654
HumanPhenoAbnormal venous morphology

MTRR SMAD2 SMAD3 SMAD4

2.37e-0336294HP:0002624
HumanPhenoJuvenile aseptic necrosis

SMAD2 SMAD3

2.41e-034392HP:0100323
HumanPhenoCoronary artery atherosclerosis

SMAD2 SMAD3 SMAD4

2.47e-0316693HP:0001677
HumanPhenoSoft skin

SMAD2 SMAD3

2.53e-034492HP:0000977
HumanPhenoAortic dilatation

SMAD2 SMAD3 SMAD4

2.56e-0316893HP:0001724
HumanPhenoLong toe

SMAD2 SMAD3 SMAD4

2.56e-0316893HP:0010511
HumanPhenoAortic aneurysm

SMAD2 SMAD3 SMAD4

2.56e-0316893HP:0004942
HumanPhenoAbnormal cerebral artery morphology

SMAD2 SMAD3 SMAD4

2.69e-0317193HP:0009145
HumanPhenoAbnormal intervertebral disk morphology

SMAD2 SMAD3

2.76e-034692HP:0005108
HumanPhenoAbnormal cardiac ventricular function

SMAD2 SMAD3 SMAD4

2.78e-0317393HP:0030872
HumanPhenoAplasia/hypoplasia affecting bones of the axial skeleton

LAMA5 CHD6 SMAD2 SMAD3 SMAD4 LARGE1

2.87e-03100896HP:0009122
HumanPhenoBruising susceptibility

SMAD2 SMAD3 SMAD4

3.02e-0317893HP:0000978
HumanPhenoAbnormal arterial physiology

SMAD2 SMAD3 SMAD4

3.16e-0318193HP:0025323
HumanPhenoAbnormal coronary artery morphology

SMAD2 SMAD3 SMAD4

3.16e-0318193HP:0006704
HumanPhenoPregnancy history

SMAD2 SMAD3 SMAD4

3.21e-0318293HP:0002686
HumanPhenoPast medical history

SMAD2 SMAD3 SMAD4

3.26e-0318393HP:0032443
MousePhenorostral body truncation

SMAD1 SMAD2 SMAD4

3.28e-0621203MP:0012157
MousePhenoabnormal rostral-caudal axis patterning

SMAD1 SMAD2 SMAD4 SMAD5

3.27e-05132204MP:0005221
MousePhenoabnormal visceral endoderm morphology

SMAD1 SMAD2 SMAD4

1.08e-0466203MP:0011186
MousePhenoabnormal proximal-distal axis patterning

SMAD2 SMAD4

1.50e-0413202MP:0001705
MousePhenoabnormal mesoderm development

SMAD1 SMAD4 SMAD5

1.52e-0474203MP:0001680
MousePhenoabnormal craniofacial development

LAMA5 SUPV3L1 SMAD1 SMAD2 SMAD5

2.70e-04425205MP:0003935
MousePhenoabnormal chorioallantoic fusion

SMAD1 SMAD2 SMAD5

2.72e-0490203MP:0002824
MousePhenoabnormal embryonic epiblast morphology

SMAD1 SMAD2 SMAD4

3.09e-0494203MP:0003886
MousePhenoabnormal egg cylinder morphology

SUPV3L1 SMAD2 SMAD4

3.09e-0494203MP:0003085
MousePhenoabsent egg cylinders

SUPV3L1 SMAD4

3.64e-0420202MP:0001694
MousePhenoabnormal bilaminar embryonic disk morphology

SMAD1 SMAD2 SMAD4

3.93e-04102203MP:0012103
MousePhenoabnormal ventral body wall morphology

SMAD1 SMAD5

4.02e-0421202MP:0003384
MousePhenoabnormal allantois morphology

SMAD1 SMAD2 SMAD5

5.17e-04112203MP:0001726
MousePhenodecreased primordial germ cell number

SMAD1 SMAD5

7.71e-0429202MP:0008392
MousePhenoabnormal foregut morphology

SMAD2 SMAD5

8.26e-0430202MP:0000474
MousePhenoabnormal extraembryonic ectoderm morphology

SMAD1 SMAD2

8.82e-0431202MP:0010736
MousePhenoabnormal primordial germ cell morphology

SMAD1 SMAD5

1.00e-0333202MP:0008391
MousePhenoabnormal embryonic-extraembryonic boundary morphology

SMAD2 SMAD4

1.06e-0334202MP:0003890
MousePhenoabnormal germ layer development

SMAD1 SMAD4 SMAD5

1.07e-03144203MP:0001674
MousePhenoabnormal polar trophectoderm morphology

SMAD2 SMAD4

1.40e-0339202MP:0012056
MousePhenoabnormal ectoplacental cone morphology

SMAD2 SMAD4

1.40e-0339202MP:0005032
MousePhenoabnormal placenta development

SMAD1 SMAD2 SMAD5

1.45e-03160203MP:0001712
DomainDwarfin

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

6.39e-178246IPR013790
Domain-

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

6.39e-1782463.90.520.10
DomainMAD_homology_MH1

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

6.39e-178246IPR013019
DomainMH2

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

6.39e-178246PS51076
DomainMH1

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

6.39e-178246PS51075
DomainMH2

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

6.39e-178246PF03166
DomainSMAD_dom_Dwarfin-type

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

6.39e-178246IPR001132
DomainDWB

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

6.39e-178246SM00524
DomainMH1

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

2.10e-1512246PF03165
DomainMAD_homology1_Dwarfin-type

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

2.10e-1512246IPR003619
DomainDWA

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

2.10e-1512246SM00523
DomainSMAD_dom-like

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.81e-1416246IPR017855
Domain-

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.81e-14162462.60.200.10
DomainSMAD_FHA_domain

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

4.48e-1152246IPR008984
DomainMRGPCRFAMILY

MRGPRX2 MRGPRX4

8.64e-0511242IPR026234
DomainDefensin_beta-typ

DEFB130B DEFB130A

1.04e-0412242IPR001855
DomainDefensin_beta

DEFB130B DEFB130A

1.04e-0412242PF00711
DomainHelicase_C

SHPRH SUPV3L1 CHD6

3.39e-04107243PF00271
DomainHELICc

SHPRH SUPV3L1 CHD6

3.39e-04107243SM00490
DomainHelicase_C

SHPRH SUPV3L1 CHD6

3.48e-04108243IPR001650
DomainHELICASE_CTER

SHPRH SUPV3L1 CHD6

3.58e-04109243PS51194
DomainHELICASE_ATP_BIND_1

SHPRH SUPV3L1 CHD6

3.58e-04109243PS51192
DomainSNF2_N

SHPRH CHD6

7.67e-0432242PF00176
DomainSNF2_N

SHPRH CHD6

7.67e-0432242IPR000330
DomainDEXDc

SHPRH CHD6

8.57e-03109242SM00487
DomainHelicase_ATP-bd

SHPRH CHD6

8.72e-03110242IPR014001
PathwayWP_TGFBETA_SIGNALING_PATHWAY

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

7.85e-1153206MM15880
PathwayWP_TGFBETA_RECEPTOR_SIGNALING

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

9.90e-1155206M39351
PathwayKEGG_MEDICUS_REFERENCE_BMP15_SIGNALING_PATHWAY

SMAD1 SMAD4 SMAD5 SMAD9

1.03e-107204M47845
PathwayWP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.53e-1059206M39886
PathwayKEGG_MEDICUS_REFERENCE_MYOSTATIN_SIGNALING_PATHWAY

SMAD1 SMAD4 SMAD5 SMAD9

2.05e-108204M47847
PathwayKEGG_MEDICUS_REFERENCE_AMH_SIGNALING_PATHWAY

SMAD1 SMAD4 SMAD5 SMAD9

3.69e-109204M47844
PathwayKEGG_MEDICUS_REFERENCE_BMP9_10_SIGNALING_PATHWAY

SMAD1 SMAD4 SMAD5 SMAD9

3.69e-109204M47822
PathwayPID_ALK2_PATHWAY

SMAD1 SMAD4 SMAD5 SMAD9

9.66e-1011204M203
PathwayKEGG_MEDICUS_REFERENCE_BMP_HAMP_SIGNALING_PATHWAY

SMAD1 SMAD4 SMAD5 SMAD9

9.66e-1011204M47848
PathwayWP_NEOVASCULARIZATION_PROCESSES

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

1.42e-0937205M39506
PathwayKEGG_TGF_BETA_SIGNALING_PATHWAY

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.56e-0986206M2642
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.07e-08118206MM15588
PathwayKEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY

SMAD1 SMAD4 SMAD5 SMAD9

1.41e-0820204M47843
PathwayPID_ALK1_PATHWAY

SMAD1 SMAD4 SMAD5 SMAD9

4.32e-0826204M185
PathwayREACTOME_SIGNALING_BY_NODAL

SMAD2 SMAD3 SMAD4

4.87e-086203MM14517
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

6.86e-08161206M27871
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES

SMAD2 SMAD3 SMAD4

8.52e-087203MM15661
PathwayREACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER

SMAD2 SMAD3 SMAD4

8.52e-087203M29623
PathwayREACTOME_SIGNALING_BY_BMP

SMAD1 SMAD4 SMAD5 SMAD9

9.04e-0831204M1662
PathwayREACTOME_SIGNALING_BY_BMP

SMAD1 SMAD4 SMAD5 SMAD9

9.04e-0831204MM14789
PathwayKEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY

SMAD2 SMAD3 SMAD4

1.36e-078203M47415
PathwayKEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY

SMAD2 SMAD3 SMAD4

1.36e-078203M47849
PathwayKEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY

SMAD2 SMAD3 SMAD4

1.36e-078203M47846
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER

SMAD2 SMAD3 SMAD4

1.36e-078203M27246
PathwayPID_BMP_PATHWAY

SMAD1 SMAD4 SMAD5 SMAD9

3.19e-0742204M181
PathwayWP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

3.40e-07108205M48078
PathwayWP_TGFB_SMAD_SIGNALING

SMAD2 SMAD3 SMAD4

5.33e-0712203M48091
PathwayWP_ID_SIGNALING_PATHWAY

SMAD1 SMAD3 SMAD4 SMAD5

6.51e-0750204MM15817
PathwayWP_BMP2WNT4FOXO1_PATHWAY_IN_PRIMARY_ENDOMETRIAL_STROMAL_CELL_DIFFERENTIATION

SMAD1 SMAD5 SMAD9

6.92e-0713203M39378
PathwayREACTOME_SIGNALING_BY_ACTIVIN

SMAD2 SMAD3 SMAD4

1.10e-0615203MM14593
PathwayPID_SMAD2_3PATHWAY

SMAD2 SMAD3 SMAD4

1.35e-0616203M228
PathwayREACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION

SMAD2 SMAD3 SMAD4

1.64e-0617203M45017
PathwayWP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING

SMAD2 SMAD3 SMAD4

1.64e-0617203M39686
PathwayBIOCARTA_TGFB_PATHWAY

SMAD2 SMAD3 SMAD4

1.64e-0617203MM1509
PathwayREACTOME_FORMATION_OF_DEFINITIVE_ENDODERM

SMAD2 SMAD3 SMAD4

1.64e-0617203M48030
PathwayREACTOME_SIGNALING_BY_ACTIVIN

SMAD2 SMAD3 SMAD4

1.64e-0617203M26965
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES

SMAD2 SMAD3 SMAD4

1.64e-0617203M27946
PathwayWP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION

SMAD2 SMAD3 SMAD4

2.33e-0619203M39370
PathwayBIOCARTA_TGFB_PATHWAY

SMAD2 SMAD3 SMAD4

2.33e-0619203M18933
PathwayWP_BMP_SIGNALING_PATHWAY_IN_EYELID_DEVELOPMENT

SMAD1 SMAD4 SMAD5

2.74e-0620203MM15907
PathwayWP_BMP_SIGNALING_IN_EYELID_DEVELOPMENT

SMAD1 SMAD4 SMAD5

2.74e-0620203M39624
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION

SMAD2 SMAD3 SMAD4

3.70e-0622203MM15656
PathwayWP_PROGERIAASSOCIATED_LIPODYSTROPHY

SMAD2 SMAD3 SMAD4

3.70e-0622203M42534
PathwayREACTOME_SIGNALING_BY_NODAL

SMAD2 SMAD3 SMAD4

4.25e-0623203M511
PathwayWP_CLOCKCONTROLLED_AUTOPHAGY_IN_BONE_METABOLISM

SMAD1 SMAD4 SMAD5 SMAD9

4.35e-0680204M45523
PathwayBIOCARTA_CTCF_PATHWAY

SMAD1 SMAD4 SMAD5

4.85e-0624203M11420
PathwayREACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY

SMAD2 SMAD3 SMAD4

4.85e-0624203MM14877
PathwayBIOCARTA_CTCF_PATHWAY

SMAD1 SMAD4 SMAD5

4.85e-0624203MM1373
PathwayWP_DIFFERENTIATION_OF_WHITE_AND_BROWN_ADIPOCYTE

SMAD1 SMAD5 SMAD9

5.51e-0625203M39665
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

SMAD2 SMAD3 SMAD4

5.51e-0625203M39713
PathwayREACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION

SMAD2 SMAD3 SMAD4

6.22e-0626203MM14878
PathwayWP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS

SMAD2 SMAD3 SMAD4

8.72e-0629203M39516
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES

SMAD2 SMAD3 SMAD4

9.68e-0630203M27941
PathwayREACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY

SMAD2 SMAD3 SMAD4

1.07e-0531203M669
PathwayREACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION

SMAD2 SMAD3 SMAD4

1.69e-0536203M633
PathwayBIOCARTA_ALK_PATHWAY

SMAD1 SMAD4 SMAD5

1.84e-0537203M17400
PathwayWP_ESC_PLURIPOTENCY_PATHWAYS

SMAD1 SMAD4 SMAD5 SMAD9

1.90e-05116204MM15863
PathwayREACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION

SMAD3 SMAD4

1.91e-055202M27825
PathwayWP_EMBRYONIC_STEM_CELL_PLURIPOTENCY_PATHWAYS

SMAD1 SMAD4 SMAD5 SMAD9

1.97e-05117204M39530
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

SMAD2 SMAD3 SMAD4

2.00e-0538203MM14874
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

SMAD1 SMAD4 SMAD5 SMAD9

2.04e-05118204M39852
PathwayWP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA

SMAD2 SMAD3 SMAD4

2.33e-0540203M48337
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER

SMAD2 SMAD3 SMAD4

2.52e-0541203MM14876
PathwayREACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION

SMAD3 SMAD4

2.86e-056202MM15534
PathwayWP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY

SMAD2 SMAD3 SMAD4

3.57e-0546203M39828
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

SMAD2 SMAD3 SMAD4

3.81e-0547203M646
PathwayREACTOME_RUNX2_REGULATES_BONE_DEVELOPMENT

SMAD1 SMAD4

4.00e-057202MM15533
PathwayREACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION

SMAD3 SMAD4

4.00e-057202M27807
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER

SMAD2 SMAD3 SMAD4

4.87e-0551203M665
PathwayWP_MESODERMAL_COMMITMENT_PATHWAY

SMAD1 SMAD2 SMAD3 SMAD4

5.65e-05153204M39546
PathwayPID_TGFBR_PATHWAY

SMAD2 SMAD3 SMAD4

5.78e-0554203M286
PathwayWP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER

SMAD2 SMAD3 SMAD4

5.78e-0554203M42568
PathwayWP_10Q1121Q1123_COPY_NUMBER_VARIATION_SYNDROME

SMAD1 SMAD5 SMAD9

8.34e-0561203M48077
PathwayKEGG_COLORECTAL_CANCER

SMAD2 SMAD3 SMAD4

8.76e-0562203M14631
PathwayPID_MYC_REPRESS_PATHWAY

SMAD2 SMAD3 SMAD4

9.19e-0563203M254
PathwayWP_ALPHA_6_BETA_4_INTEGRIN_SIGNALING_PATHWAY

LAMA5 SMAD2 SMAD3

1.06e-0466203MM15925
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION

SMAD2 SMAD3 SMAD4

1.06e-0466203M27938
PathwayWP_BONE_MORPHOGENIC_PROTEIN_SIGNALING_AND_REGULATION

SMAD1 SMAD4

1.25e-0412202M39519
PathwayWP_MIR127_IN_MESENDODERM_DIFFERENTIATION

SMAD2 SMAD4

1.25e-0412202MM15910
PathwayKEGG_PANCREATIC_CANCER

SMAD2 SMAD3 SMAD4

1.26e-0470203M9726
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

SMAD1 SMAD2 SMAD3 SMAD4

1.33e-04191204MM15289
PathwayWP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER

SMAD2 SMAD3 SMAD4

1.43e-0473203M39758
PathwayKEGG_ADHERENS_JUNCTION

SMAD2 SMAD3 SMAD4

1.43e-0473203M638
PathwayWP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY

SMAD2 SMAD3 SMAD4

1.48e-0474203M48080
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

SMAD2 SMAD3 SMAD4

1.67e-0477203MM14670
PathwayREACTOME_FORMATION_OF_AXIAL_MESODERM

SMAD2 SMAD3

1.72e-0414202M46441
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

SMAD1 SMAD3 SMAD4

2.01e-0482203MM15922
PathwayPID_SMAD2_3NUCLEAR_PATHWAY

SMAD2 SMAD3 SMAD4

2.01e-0482203M2
PathwayREACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING

SMAD2 SMAD3

2.27e-0416202MM14873
PathwayREACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS

SMAD3 SMAD4

2.27e-0416202M46428
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

SMAD1 SMAD2 SMAD3 SMAD4

2.34e-04221204M27578
PathwayWP_PANCREATIC_ADENOCARCINOMA_PATHWAY

SMAD2 SMAD3 SMAD4

2.57e-0489203M39732
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

SMAD2 SMAD3 SMAD4

3.01e-0494203M1041
PathwayBIOCARTA_TOB1_PATHWAY

SMAD3 SMAD4

3.22e-0419202M18215
PathwayWP_HYPOXIADEPENDENT_PROLIFERATION_OF_MYOBLASTS

SMAD2 SMAD3

3.22e-0419202MM15811
PathwayBIOCARTA_TOB1_PATHWAY

SMAD3 SMAD4

3.22e-0419202MM1490
PathwayREACTOME_BETA_DEFENSINS

DEFB130B DEFB130A

3.58e-0420202MM14567
PathwayBIOCARTA_NTHI_PATHWAY

SMAD3 SMAD4

4.34e-0422202MM1443
PathwayWP_VITAMIN_D_IN_INFLAMMATORY_DISEASES

SMAD3 SMAD4

4.34e-0422202M39773
PathwayREACTOME_DEUBIQUITINATION

SMAD1 SMAD2 SMAD3 SMAD4

4.47e-04262204MM15286
Pubmed

Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

5.48e-20624611850197
Pubmed

Negative regulation of BMP/Smad signaling by Tob in osteoblasts.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

3.83e-19724611163184
Pubmed

A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.53e-18824619211612
Pubmed

Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.53e-18824610647776
Pubmed

TGF-beta signaling by Smad proteins.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.53e-18824610708949
Pubmed

TGF-beta signal transduction.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

4.60e-1892469759503
Pubmed

The Smad pathway.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

4.60e-18924610708948
Pubmed

TGF-β signaling inhibits canonical BMP signaling pathway during palate development.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.15e-171024629247325
Pubmed

Spatio-temporal distribution of Smads and role of Smads/TGF-β/BMP-4 in the regulation of mouse bladder organogenesis.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.15e-171024623620745
Pubmed

Downregulation of bone morphogenetic protein receptor axis during HIV-1 and cocaine-mediated pulmonary smooth muscle hyperplasia: implications for HIV-related pulmonary arterial hypertension.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

2.53e-171124624008158
Pubmed

Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development.

LAMA5 SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

5.05e-171224617460146
Pubmed

Smad expression during kidney development.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

5.05e-171224614656760
Pubmed

Endoglin is required for myogenic differentiation potential of neural crest stem cells.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

9.37e-171324617628518
Pubmed

Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

1.00e-16524525141865
Pubmed

An atypical canonical bone morphogenetic protein (BMP) signaling pathway regulates Msh homeobox 1 (Msx1) expression during odontogenesis.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.64e-161424625274628
Pubmed

Loss of Smad4 in the scleraxis cell lineage results in postnatal joint contracture.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.64e-161424633248111
Pubmed

Smad7 is required for the development and function of the heart.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

6.01e-16624518952608
Pubmed

Immunohistochemical expression of Smads 1-6 in the 15-day gestation mouse embryo: signaling by BMPs and TGF-betas.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

6.01e-16624511169847
Pubmed

SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

6.01e-16624510400677
Pubmed

Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

2.10e-15724515009097
Pubmed

Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

2.10e-15724510376010
Pubmed

Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

2.10e-15724512370310
Pubmed

Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

2.10e-15724514699069
Pubmed

Myocardial smad4 is essential for cardiogenesis in mouse embryos.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

4.06e-152224617585069
Pubmed

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

5.61e-15824510531362
Pubmed

Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

5.61e-15824523804438
Pubmed

Holding their own: the noncanonical roles of Smad proteins.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

1.26e-14924519018011
Pubmed

GATA4 is essential for bone mineralization via ERα and TGFβ/BMP pathways.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

1.26e-14924524932701
Pubmed

Dullard/Ctdnep1 regulates endochondral ossification via suppression of TGF-β signaling.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

1.26e-14924525155999
Pubmed

Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

1.26e-14924530134160
Pubmed

Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD9

1.26e-14924526555259
Pubmed

Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

1.26e-14924524816837
Pubmed

Protein Arginine Methyltransferase PRMT1 Is Essential for Palatogenesis.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

2.52e-141024529986157
Pubmed

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor.

SMAD1 SMAD2 SMAD4 SMAD5 SMAD9

2.52e-14102459436979
Pubmed

Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

2.52e-141024512543979
Pubmed

ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

3.99e-143124636445780
Pubmed

Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

4.62e-141124527741240
Pubmed

BMPR-II is dispensable for formation of the limb skeleton.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

7.92e-141224521538804
Pubmed

Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum.

SMAD1 SMAD2 SMAD4 SMAD5 SMAD9

7.92e-141224515923624
Pubmed

Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

1.29e-131324516959237
Pubmed

Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

1.29e-131324518329379
Pubmed

Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4.

SMAD1 SMAD2 SMAD3 SMAD4

1.74e-1342449111321
Pubmed

Investigation of DNA polymorphisms in SMAD genes for genetic predisposition to diabetic nephropathy in patients with type 1 diabetes mellitus.

SMAD1 SMAD3 SMAD4 SMAD5

1.74e-13424419247629
Pubmed

Signal transduction of bone morphogenetic protein receptors.

SMAD1 SMAD4 SMAD5 SMAD9

1.74e-13424414687659
Pubmed

Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers.

SMAD1 SMAD2 SMAD3 SMAD4

1.74e-13424421724602
Pubmed

Functions of mammalian Smad genes as revealed by targeted gene disruption in mice.

SMAD2 SMAD3 SMAD4 SMAD5

1.74e-13424410708952
Pubmed

Matrix GLA protein, an inhibitory morphogen in pulmonary vascular development.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

2.00e-131424517670744
Pubmed

The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart function.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

2.00e-131424538951500
Pubmed

The function of growth/differentiation factor 11 (Gdf11) in rostrocaudal patterning of the developing spinal cord.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

2.00e-131424516790475
Pubmed

Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

2.00e-131424516435884
Pubmed

Tbx1 genetically interacts with the transforming growth factor-β/bone morphogenetic protein inhibitor Smad7 during great vessel remodeling.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

3.00e-131524523011393
Pubmed

Epicardial calcineurin-NFAT signals through Smad2 to direct coronary smooth muscle cell and arterial wall development.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

3.00e-131524523946498
Pubmed

The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation.

LAMA5 SMAD1 SMAD4 SMAD5 SMAD9

4.36e-131624519733164
Pubmed

A TGFβ-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development.

SMAD1 SMAD3 SMAD4 SMAD5 SMAD9

4.36e-131624522438570
Pubmed

Spatial and temporal expression of molecular markers and cell signals during normal development of the mouse patellar tendon.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

4.36e-131624521939397
Pubmed

Dynamic signaling network for the specification of embryonic pancreas and liver progenitors.

SMAD1 SMAD2 SMAD4 SMAD5 SMAD9

4.36e-131624519556507
Pubmed

SMAD4 is essential for generating subtypes of neurons during cerebellar development.

SMAD1 SMAD2 SMAD4 SMAD5 SMAD9

6.17e-131724522370000
Pubmed

Smad4 controls proliferation of interstitial cells in the neonatal kidney.

SMAD1 SMAD3 SMAD4 SMAD5 SMAD9

6.17e-131724534878095
Pubmed

Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

6.60e-134824627703004
Pubmed

Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

8.54e-131824527720610
Pubmed

TGF-β-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

8.54e-131824523546880
Pubmed

Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells.

SMAD1 SMAD4 SMAD5 SMAD9

8.71e-13524411121043
Pubmed

Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival.

SMAD1 SMAD2 SMAD4 SMAD5

8.71e-13524418566469
Pubmed

Carboxy-terminally truncated Gli3 proteins associate with Smads.

SMAD1 SMAD2 SMAD3 SMAD4

8.71e-1352449843199
Pubmed

The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines.

SMAD1 SMAD2 SMAD3 SMAD5

8.71e-13524415647271
Pubmed

Smad8B, a Smad8 splice variant lacking the SSXS site that inhibits Smad8-mediated signalling.

SMAD1 SMAD4 SMAD5 SMAD9

8.71e-13524410583507
Pubmed

Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor-beta signaling.

SMAD1 SMAD2 SMAD3 SMAD4

8.71e-13524411387330
Pubmed

Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation.

SMAD1 SMAD2 SMAD3 SMAD4

8.71e-13524412808092
Pubmed

Smad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors.

SMAD1 SMAD2 SMAD3 SMAD5

8.71e-13524419819941
Pubmed

USP15 is a deubiquitylating enzyme for receptor-activated SMADs.

SMAD1 SMAD2 SMAD3 SMAD4

8.71e-13524421947082
Pubmed

The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter.

SMAD1 SMAD3 SMAD4 SMAD5

8.71e-13524417251190
Pubmed

Mad-related genes in the human.

SMAD1 SMAD2 SMAD3 SMAD5

8.71e-1352448673135
Pubmed

Augmented BMPRIA-mediated BMP signaling in cranial neural crest lineage leads to cleft palate formation and delayed tooth differentiation.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

1.16e-121924523776616
Pubmed

Fgf9 signaling regulates small intestinal elongation and mesenchymal development.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

1.54e-122024518653563
Pubmed

RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

1.54e-122024532662771
Pubmed

Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways.

SMAD1 SMAD2 SMAD3 SMAD4

2.61e-12624410890911
Pubmed

Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium.

SMAD1 SMAD2 SMAD4 SMAD9

2.61e-1262449256479
Pubmed

Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons.

SMAD1 SMAD2 SMAD5 SMAD9

2.61e-12624421518886
Pubmed

Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT.

SMAD1 SMAD2 SMAD3 SMAD4

2.61e-12624412904571
Pubmed

FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.

SMAD1 SMAD2 SMAD3 SMAD4

2.61e-12624419135894
Pubmed

Control of early fate decisions in human ES cells by distinct states of TGFbeta pathway activity.

SMAD1 SMAD2 SMAD3 SMAD5

2.61e-12624418393632
Pubmed

Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins.

SMAD1 SMAD2 SMAD3 SMAD4

2.61e-12624411160896
Pubmed

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.

SMAD1 SMAD2 SMAD3 SMAD4

2.61e-1262448774881
Pubmed

Genetic variation in the TGF-β signaling pathway and colon and rectal cancer risk.

SMAD1 SMAD2 SMAD3 SMAD4

2.61e-12624421068203
Pubmed

PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue.

SMAD1 SMAD2 SMAD3 SMAD4

2.61e-12624417467076
Pubmed

Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1.

SMAD1 SMAD2 SMAD3 SMAD4

2.61e-12624415849193
Pubmed

SMAD expression in the testis: an insight into BMP regulation of spermatogenesis.

SMAD1 SMAD4 SMAD5 SMAD9

2.61e-12624418069690
Pubmed

Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse.

SMAD1 SMAD2 SMAD4 SMAD5 SMAD9

3.35e-122324530842446
Pubmed

Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

3.35e-122324521937600
Pubmed

Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion.

LAMA5 SMAD1 SMAD2 SMAD5 SMAD9

3.35e-122324529981310
Pubmed

Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfβ-Id2 axis, for tissue regeneration.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

4.22e-122424534129836
Pubmed

Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

4.22e-122424516943282
Pubmed

Neural crest cell-autonomous roles of fibronectin in cardiovascular development.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

4.22e-122424526552887
Pubmed

Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression.

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

5.28e-122524520019329
Pubmed

Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction.

SMAD1 SMAD2 SMAD5 SMAD9

6.09e-12724415376321
Pubmed

CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription.

SMAD1 SMAD2 SMAD3 SMAD4

6.09e-12724414701756
Pubmed

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling.

SMAD1 SMAD2 SMAD3 SMAD5

6.09e-12724414580334
Pubmed

Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation.

SMAD1 SMAD2 SMAD3 SMAD4

6.09e-12724412874272
Pubmed

A component of the ARC/Mediator complex required for TGF beta/Nodal signalling.

SMAD1 SMAD2 SMAD3 SMAD4

6.09e-12724412167862
Pubmed

Pkd1 is required for male reproductive tract development.

SMAD1 SMAD2 SMAD3 SMAD5

6.09e-12724423933588
InteractionTOB1 interactions

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

7.46e-1244236int:TOB1
InteractionSMAD5 interactions

SMAD1 SMAD2 SMAD3 SMAD4 ARRDC3 SMAD5 SMAD9

1.48e-11101237int:SMAD5
InteractionCSH2 interactions

SMAD2 SMAD3 SMAD4 SMAD9

1.74e-0915234int:CSH2
InteractionCSH1 interactions

SMAD2 SMAD3 SMAD4 SMAD9

3.90e-0918234int:CSH1
InteractionRASL12 interactions

SMAD1 SMAD2 SMAD3 SMAD4

6.17e-0920234int:RASL12
InteractionHMGA2 interactions

SUPV3L1 SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

9.24e-09140236int:HMGA2
InteractionCOL5A1 interactions

LAMA5 SMAD1 SMAD2 SMAD3 SMAD4

9.60e-0965235int:COL5A1
InteractionZNF8 interactions

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

1.40e-0870235int:ZNF8
InteractionSMAD9 interactions

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.57e-08153236int:SMAD9
InteractionRASD2 interactions

SMAD1 SMAD2 SMAD3 SMAD4

1.60e-0825234int:RASD2
InteractionZEB2 interactions

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

6.58e-0895235int:ZEB2
InteractionRAB38 interactions

SMAD1 SMAD2 SMAD3 SMAD4

9.27e-0838234int:RAB38
InteractionCOL3A1 interactions

SMAD1 SMAD2 SMAD3 SMAD4

1.03e-0739234int:COL3A1
InteractionCYP11A1 interactions

SMAD2 SMAD3 SMAD9

1.09e-079233int:CYP11A1
InteractionSMAD2 interactions

LAMA5 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.66e-07385237int:SMAD2
InteractionSMAD1 interactions

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

2.46e-07243236int:SMAD1
InteractionSMAD7 interactions

SMAD1 SMAD2 SMAD3 SMAD4 SMAD9

2.82e-07127235int:SMAD7
InteractionMED24 interactions

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

2.93e-07128235int:MED24
InteractionWWP1 interactions

SMAD1 SMAD2 SMAD3 SMAD4 ARRDC3 SMAD5

3.66e-07260236int:WWP1
InteractionSMAD6 interactions

SMAD1 SMAD2 SMAD4 SMAD5

4.55e-0756234int:SMAD6
InteractionRUNX3 interactions

SMAD1 SMAD2 SMAD3 SMAD5

6.44e-0761234int:RUNX3
InteractionSKI interactions

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

8.88e-07160235int:SKI
InteractionRHEBL1 interactions

SMAD1 SMAD2 SMAD4

1.05e-0618233int:RHEBL1
InteractionLEF1 interactions

SMAD1 SMAD2 SMAD3 SMAD4

1.06e-0669234int:LEF1
InteractionSMAD4 interactions

SUPV3L1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.42e-06530237int:SMAD4
InteractionKAT2A interactions

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

1.59e-06180235int:KAT2A
InteractionMBD1 interactions

SMAD1 SMAD3 SMAD5 SMAD9

1.65e-0677234int:MBD1
InteractionNOTCH4 interactions

SMAD2 SMAD3 SMAD4

1.70e-0621233int:NOTCH4
InteractionSMURF2 interactions

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

1.82e-06185235int:SMURF2
InteractionGJB6 interactions

SMAD1 SMAD5 SMAD9

1.97e-0622233int:GJB6
InteractionPAPPA interactions

SMAD2 SMAD3 SMAD9

1.97e-0622233int:PAPPA
InteractionHOXA13 interactions

SMAD1 SMAD2 SMAD5

1.97e-0622233int:HOXA13
InteractionCXXC5 interactions

SMAD3 SMAD5 SMAD9

1.97e-0622233int:CXXC5
InteractionPSG9 interactions

SMAD2 SMAD4 SMAD9

1.97e-0622233int:PSG9
InteractionZNF510 interactions

SMAD1 SMAD2 SMAD4

2.59e-0624233int:ZNF510
InteractionEID2 interactions

SMAD2 SMAD3 SMAD4

2.59e-0624233int:EID2
InteractionPEX6 interactions

SMAD1 SMAD2 SMAD3 SMAD4

2.82e-0688234int:PEX6
InteractionFOXG1 interactions

SMAD1 SMAD2 SMAD3 SMAD4

3.83e-0695234int:FOXG1
InteractionGLI3 interactions

SMAD1 SMAD2 SMAD3 SMAD4

4.34e-0698234int:GLI3
InteractionKDM6B interactions

SMAD1 SMAD2 SMAD3 SMAD4

5.49e-06104234int:KDM6B
InteractionUSP9X interactions

SUPV3L1 SMAD1 SMAD2 SMAD3 SMAD4 ARRDC3

6.07e-06422236int:USP9X
InteractionBACH1 interactions

SMAD1 SMAD3 SMAD5 SMAD9

7.12e-06111234int:BACH1
InteractionSMAD3 interactions

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

8.44e-06447236int:SMAD3
InteractionSKIL interactions

SMAD1 SMAD2 SMAD3 SMAD4

9.38e-06119234int:SKIL
InteractionFOXO3 interactions

SMAD1 SMAD2 SMAD3 SMAD4

1.10e-05124234int:FOXO3
InteractionITGB4 interactions

LAMA5 SMAD2 SMAD3 ARRDC3

1.14e-05125234int:ITGB4
InteractionLEMD3 interactions

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

1.17e-05271235int:LEMD3
InteractionRUNX2 interactions

SMAD1 SMAD2 SMAD3 SMAD5

1.18e-05126234int:RUNX2
InteractionTGIF1 interactions

SMAD1 SMAD2 SMAD3

1.35e-0541233int:TGIF1
InteractionKLF10 interactions

SMAD1 SMAD5 SMAD9

1.79e-0545233int:KLF10
InteractionPARD3 interactions

SMAD1 SMAD2 SMAD3 SMAD4 ARRDC3

1.85e-05298235int:PARD3
InteractionEIF4ENIF1 interactions

SUPV3L1 SMAD1 SMAD2 SMAD3 SMAD4

1.91e-05300235int:EIF4ENIF1
InteractionHGS interactions

SMAD1 SMAD2 SMAD3 SMAD4 ARRDC3 SMAD5

2.06e-05523236int:HGS
InteractionDVL1 interactions

SMAD1 SMAD2 SMAD3 SMAD4

2.40e-05151234int:DVL1
InteractionGDF6 interactions

SMAD1 SMAD5

2.61e-057232int:GDF6
InteractionMXI1 interactions

SMAD1 SMAD5 SMAD9

3.28e-0555233int:MXI1
InteractionPIAS4 interactions

SMAD1 SMAD2 SMAD3 SMAD4

4.09e-05173234int:PIAS4
InteractionPSMD11 interactions

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5

4.16e-05353235int:PSMD11
InteractionARID1B interactions

SMAD2 SMAD3 SMAD4 SMAD9

4.47e-05177234int:ARID1B
InteractionCHMP3 interactions

SMAD1 SMAD4 SMAD5

4.93e-0563233int:CHMP3
InteractionPAX6 interactions

CHD6 SMAD1 SMAD3 SMAD4 SMAD5

4.94e-05366235int:PAX6
InteractionMYOD1 interactions

SMAD1 SMAD2 SMAD3 SMAD4

6.39e-05194234int:MYOD1
InteractionPRDM16 interactions

SMAD1 SMAD2 SMAD3 SMAD4

6.52e-05195234int:PRDM16
InteractionNUP214 interactions

SMAD1 SMAD2 SMAD3 SMAD4

6.52e-05195234int:NUP214
InteractionZNF83 interactions

SMAD3 SMAD9

8.17e-0512232int:ZNF83
InteractionRGCC interactions

SMAD2 SMAD3

8.17e-0512232int:RGCC
InteractionCDKN2B interactions

SMAD2 SMAD3 SMAD4

8.99e-0577233int:CDKN2B
InteractionRELB interactions

SMAD2 SMAD3 SMAD4

9.34e-0578233int:RELB
InteractionSVEP1 interactions

SMAD3 SMAD9

9.64e-0513232int:SVEP1
InteractionNKX3-2 interactions

SMAD1 SMAD4

9.64e-0513232int:NKX3-2
InteractionRAB34 interactions

SMAD1 SMAD2 SMAD4

9.70e-0579233int:RAB34
InteractionRAB2B interactions

VPS13C SMAD1 SMAD4

1.05e-0481233int:RAB2B
InteractionRFX1 interactions

SMAD1 SMAD4 SMAD9

1.05e-0481233int:RFX1
InteractionCDK8 interactions

SMAD1 SMAD2 SMAD3 SMAD5

1.08e-04222234int:CDK8
InteractionPKNOX1 interactions

SMAD2 SMAD3 SMAD4

1.08e-0482233int:PKNOX1
InteractionHOXD13 interactions

SMAD1 SMAD2 SMAD5

1.08e-0482233int:HOXD13
InteractionHYAL2 interactions

SMAD2 SMAD3 SMAD4

1.12e-0483233int:HYAL2
InteractionPBX1 interactions

SMAD2 SMAD3 SMAD4

1.21e-0485233int:PBX1
InteractionNEDD9 interactions

SMAD1 SMAD2 SMAD3

1.21e-0485233int:NEDD9
InteractionGSC interactions

SMAD1 SMAD2 SMAD3

1.29e-0487233int:GSC
InteractionDNMT3L interactions

SMAD1 SMAD3 SMAD4

1.34e-0488233int:DNMT3L
InteractionCAMK2G interactions

SMAD2 SMAD3 SMAD4 ARRDC3

1.45e-04240234int:CAMK2G
InteractionZSCAN4 interactions

SMAD1 SMAD9

1.48e-0416232int:ZSCAN4
InteractionEBI3 interactions

SMAD3 IL27RA

1.68e-0417232int:EBI3
InteractionPIAS3 interactions

SMAD2 SMAD3 SMAD4

1.68e-0495233int:PIAS3
InteractionACVR1B interactions

SMAD2 SMAD3 SMAD4

1.68e-0495233int:ACVR1B
InteractionSQOR interactions

SMAD2 SMAD3 ARRDC3

1.84e-0498233int:SQOR
InteractionHIPK2 interactions

SMAD1 SMAD2 SMAD3

1.84e-0498233int:HIPK2
InteractionKAT2B interactions

SMAD1 SMAD2 SMAD3 SMAD9

1.86e-04256234int:KAT2B
InteractionTGFBR1 interactions

SMAD1 SMAD2 SMAD3 SMAD4

1.92e-04258234int:TGFBR1
InteractionIRF7 interactions

SMAD2 SMAD3 SMAD4

1.95e-04100233int:IRF7
InteractionARHGEF6 interactions

SMAD1 SMAD2 SMAD3

1.95e-04100233int:ARHGEF6
InteractionMED6 interactions

SMAD1 SMAD2 SMAD3

2.01e-04101233int:MED6
InteractionABTB1 interactions

SMAD2 SMAD9

2.11e-0419232int:ABTB1
InteractionERBIN interactions

SMAD1 SMAD2 SMAD3 SMAD4

2.13e-04265234int:ERBIN
InteractionDACH1 interactions

SMAD1 SMAD3 SMAD4

2.19e-04104233int:DACH1
InteractionZMYM2 interactions

SMAD1 SMAD2 SMAD3 SMAD4

2.32e-04271234int:ZMYM2
InteractionZFYVE9 interactions

CHD6 SMAD2 SMAD3

2.32e-04106233int:ZFYVE9
InteractionC1orf116 interactions

SMAD2 SMAD3

2.34e-0420232int:C1orf116
InteractionFOXH1 interactions

SMAD2 SMAD3 SMAD4

2.52e-04109233int:FOXH1
Cytoband18q21.1

SMAD2 SMAD4

1.82e-043824218q21.1
Cytoband11p15.1

MRGPRX2 MRGPRX4

4.55e-046024211p15.1
CytobandEnsembl 112 genes in cytogenetic band chr15q22

VPS13C SMAD3

2.17e-03132242chr15q22
Cytoband8p23.1

DEFB130B DEFB130A

2.94e-031542428p23.1
CytobandEnsembl 112 genes in cytogenetic band chr18q21

SMAD2 SMAD4

5.13e-03205242chr18q21
CytobandEnsembl 112 genes in cytogenetic band chr8p23

DEFB130B DEFB130A

6.63e-03234242chr8p23
GeneFamilySMAD family

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.07e-178186750
GeneFamilyG protein-coupled receptors, Class A orphans

MRGPRX2 MRGPRX4

2.69e-0378182262
CoexpressionTURJANSKI_MAPK1_AND_MAPK2_TARGETS

SMAD1 SMAD2 SMAD3 SMAD4

2.22e-1012234M15804
CoexpressionGU_PDEF_TARGETS_UP

SMAD1 SMAD2 SMAD3 SMAD4

4.21e-0771234M3955
CoexpressionGSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN

SUPV3L1 SMAD1 SMAD3 LARGE1

2.60e-05200234M3969
CoexpressionMATZUK_EMBRYONIC_GERM_CELL

SMAD1 SMAD5

1.25e-0419232M1821
CoexpressionKOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP

SMAD1 SMAD4 SMAD5

1.47e-04118233M12313
Drug1,3,2-dioxaborolan-2-ol

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

7.44e-10104236CID005289333
DrugAC1L1K15

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

1.77e-09120236CID000005293
Druglanthanum carbide

SMAD1 SMAD2 SMAD3 SMAD9

3.04e-0919234CID000123280
Drug3 tp

SMAD1 SMAD2 SMAD3 SMAD4 SMAD9

5.67e-0966235CID009549240
DrugMW 1

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

7.08e-09151236CID000073965
Drug5-methoxypsoralen

SMAD1 SMAD5 SMAD9

3.14e-087233ctd:C022909
DrugMcat

SMAD1 SMAD2 SMAD3 SMAD9

4.06e-0835234CID003080785
DrugLDN 193189

SMAD1 SMAD5 SMAD9

5.03e-088233ctd:C554430
DrugAC1L9Q5W

SMAD1 SMAD2 SMAD3 SMAD4 SMAD9

6.26e-08106235CID000452221
DrugNSC350854

SMAD1 SMAD2 SMAD3 SMAD4 SMAD9

6.88e-08108235CID000434448
DrugLY2109761

SMAD1 SMAD2 SMAD3

1.08e-0710233ctd:C530108
Druggalangin

SMAD1 SMAD2 SMAD3 SMAD4

6.17e-0768234ctd:C037032
Drugimperatorin

SMAD1 SMAD5 SMAD9

1.37e-0622233ctd:C031534
DrugAC1L9RT0

SMAD1 SMAD3 SMAD4

1.37e-0622233CID000454702
Drugrhodioloside

SMAD1 SMAD5 SMAD9

4.38e-0632233ctd:C009172
DrugMDPC

SMAD1 SMAD3 SMAD4

8.04e-0639233CID000032842
DrugCytochalasin D

SMAD1 SMAD2 SMAD3

8.04e-0639233ctd:D015638
DrugMadecassol

SMAD2 SMAD3 SMAD4

1.33e-0546233CID000108062
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

LAMA5 SMAD1 SMAD3 IL27RA

2.38e-051702341050_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

LAMA5 SMAD1 SMAD3 IL27RA

3.04e-051812346951_DN
Drugsirtinol

SMAD1 SMAD5 SMAD9

3.28e-0562233ctd:C439060
Drugmethotrexate polyglutamate

SMAD2 SMAD4

3.50e-059232ctd:C014085
Drugprotocatechualdehyde

SMAD2 SMAD3

4.37e-0510232ctd:C005581
DrugFelbinac [5728-52-9]; Down 200; 18.8uM; HL60; HT_HG-U133A

SMAD1 IL27RA SMAD5 LARGE1

4.40e-051992343061_DN
DrugStreptozotocin [18883-66-4]; Up 200; 15uM; HL60; HT_HG-U133A

SMAD3 SMAD4 IL27RA SMAD5

4.40e-051992342535_UP
DrugWen-pi-tang-Hab-Wu-ling-san

SMAD2 SMAD3

5.34e-0511232ctd:C521629
Drugleptomycin B

SMAD2 SMAD3 SMAD4

5.57e-0574233ctd:C038753
DrugAR E

SMAD2 SMAD3 SMAD4 SMAD5

7.73e-05230234CID004369394
DrugPhloroglucinol

SMAD2 SMAD3

8.82e-0514232ctd:D010696
DrugSB203580

SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9

9.11e-05771236CID000176155
DrugSIS3

SMAD3 SMAD4

1.02e-0415232CID010138988
Drugaluminum chloride

SMAD2 SMAD3 SMAD4

1.45e-04102233ctd:C010845
Drugisoangustone A

SMAD2 SMAD4

1.48e-0418232ctd:C551631
DrugLy-364947

SMAD2 SMAD3

1.48e-0418232ctd:C520284
DrugS-nitro-N-acetylpenicillamine

SMAD3 SMAD4

2.44e-0423232ctd:C110881
Drugap1-6

SMAD3 SMAD4

2.44e-0423232CID003030073
DrugSimvastatin

SMAD1 SMAD2 SMAD3 SMAD5 SMAD9

2.44e-04581235ctd:D019821
DrugGrape Seed Extract

SMAD2 SMAD3

2.66e-0424232ctd:D056604
Drugcandesartan cilexetil

SMAD3 SMAD4

3.63e-0428232ctd:C077793
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

5.54e-041612334768_DN
Drugimidacloprid

SMAD1 SMAD5

5.69e-0435232ctd:C082359
Drugsauchinone

SMAD2 SMAD3

5.69e-0435232ctd:C410958
Drugacteoside

SMAD2 SMAD3

5.69e-0435232ctd:C058956
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

5.95e-041652336085_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

5.95e-041652332835_DN
Drugpyridinyl imidazole

SMAD2 SMAD5

6.02e-0436232CID000005171
Drugmonocrotaline pyrrole

SMAD1 SMAD4

6.02e-0436232CID000104764
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.05e-041662332247_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

LAMA5 SMAD1 IL27RA

6.05e-041662337324_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.16e-041672333979_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.27e-041682333868_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.27e-041682333395_DN
DrugSPDP

MTRR FCAMR

6.36e-0437232CID000100682
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.38e-041692336064_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

LAMA5 SMAD1 SMAD3

6.38e-041692335231_DN
DrugBW-B 70C; Up 200; 31.6uM; MCF7; HT_HG-U133A_EA

MTRR SMAD3 IL27RA

6.38e-041692331132_UP
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.49e-041702337043_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.49e-041702335260_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.60e-041712336879_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.60e-041712332777_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.71e-041722337179_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.71e-041722333428_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A_EA

SMAD1 SMAD3 IL27RA

6.71e-041722331072_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

LAMA5 SMAD1 IL27RA

6.71e-041722332794_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.71e-041722335903_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.71e-041722334112_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.83e-041732335336_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.94e-041742337105_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.94e-041742335745_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.94e-041742333462_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.94e-041742331659_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.94e-041742335945_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.94e-041742335693_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

SMAD1 SMAD3 IL27RA

6.94e-041742335940_DN
DrugSAHA; Down 200; 10uM; MCF7; HT_HG-U133A_EA

SMAD1 SMAD3 IL27RA

7.06e-041752331058_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A_EA

SMAD1 SMAD3 IL27RA

7.06e-041752331014_DN
Drug16-hydroxycleroda-3,13(14)-dien-15,16-olide

SMAD2 SMAD3

7.07e-0439232ctd:C072581
DrugSAHA; Down 200; 10uM; HL60; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.18e-041762336179_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.18e-041762335976_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.18e-041762331535_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.18e-041762333312_DN
DrugSAHA; Down 200; 10uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.18e-041762336980_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.18e-041762336784_DN
Drugtrichostatin A ; Down 200; 1uM; MCF7; HT_HG-U133A_EA

SMAD1 SMAD3 IL27RA

7.30e-04177233873_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.30e-041772337550_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.30e-041772333177_DN
Drugaristolochic acid I

SMAD1 SMAD5 SMAD9

7.42e-04178233ctd:C000228
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

SMAD1 SMAD3 IL27RA

7.42e-04178233992_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.54e-041792336910_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.54e-041792335484_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.66e-041802335981_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.66e-041802336886_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.66e-041802334821_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.78e-041812333643_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.78e-041812337077_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

SMAD1 SMAD3 IL27RA

7.91e-041822335802_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HG-U133A

SMAD1 SMAD3 IL27RA

7.91e-041822331951_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

SMAD1 SMAD3 IL27RA

8.16e-041842337555_DN
DrugSAHA; Down 200; 10uM; MCF7; HT_HG-U133A

SMAD1 SMAD3 IL27RA

8.16e-041842336939_DN
DrugU0126

SMAD1 SMAD2 SMAD3 SMAD5

8.36e-04430234CID000005637
Diseasejuvenile polyposis syndrome (implicated_via_orthology)

SMAD1 SMAD4 SMAD5 SMAD9

2.00e-1013234DOID:0050787 (implicated_via_orthology)
DiseaseIdiopathic pulmonary hypertension

SMAD1 SMAD4 SMAD9

3.46e-089233C0152171
Disease2-oxo-hept-3-ene-1,7-dioate hydratase activity

SMAD1 SMAD4 SMAD9

1.50e-0714233C1150929
DiseaseIdiopathic pulmonary arterial hypertension

SMAD1 SMAD4 SMAD9

2.30e-0716233C3203102
DiseaseFamilial primary pulmonary hypertension

SMAD1 SMAD4 SMAD9

2.79e-0717233C0340543
DiseaseLynch syndrome (is_implicated_in)

SMAD2 SMAD3 SMAD4

8.28e-0724233DOID:3883 (is_implicated_in)
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

SMAD2 SMAD3 SMAD4

9.45e-0653233C4707243
Diseasepolyp of colon

LAMA5 SMAD3 SMAD9

1.12e-0556233MONDO_0021400
DiseaseLoeys-Dietz Syndrome

SMAD2 SMAD3

1.22e-057232C2697932
DiseasePulmonary arterial hypertension

SMAD4 SMAD9

2.61e-0510232C2973725
Diseasepulmonary hypertension (biomarker_via_orthology)

SMAD1 SMAD4 SMAD9

3.27e-0580233DOID:6432 (biomarker_via_orthology)
Diseaseprogesterone measurement

SMAD2 ARRDC3

5.26e-0514232EFO_0007004
DiseaseColorectal Neoplasms

MTRR SMAD3 SMAD4 SMAD9

5.85e-05277234C0009404
Diseasepancreatic cancer (is_implicated_in)

MTRR SMAD3 SMAD4

8.92e-05112233DOID:1793 (is_implicated_in)
DiseaseCocaine-Related Disorders

SMAD1 SMAD3 SMAD5

1.02e-04117233C0236736
DiseaseLeft Ventricle Remodeling

SMAD2 SMAD3

1.21e-0421232C0600520
DiseaseVentricular Remodeling

SMAD2 SMAD3

1.21e-0421232C0600519
DiseaseCocaine Abuse

SMAD1 SMAD3 SMAD5

1.29e-04127233C0009171
DiseaseCocaine Dependence

SMAD1 SMAD3 SMAD5

1.69e-04139233C0600427
DiseaseColorectal Carcinoma

MTRR SMAD2 SMAD3 SMAD4 SMAD9

1.77e-04702235C0009402
Diseasecolorectal cancer, colorectal adenoma

LAMA5 SMAD3 SMAD9

2.20e-04152233EFO_0005406, MONDO_0005575
DiseaseCraniofacial Abnormalities

SMAD2 SMAD3 SMAD4

2.38e-04156233C0376634
Diseaseendometrial cancer (is_marker_for)

SMAD2 SMAD3

3.40e-0435232DOID:1380 (is_marker_for)
Diseasecolon cancer (biomarker_via_orthology)

SMAD2 SMAD4

4.23e-0439232DOID:219 (biomarker_via_orthology)
Diseaseovarian cancer (is_implicated_in)

SMAD2 SMAD4

8.72e-0456232DOID:2394 (is_implicated_in)
DiseaseWithdrawal Symptoms

SMAD1 SMAD5

9.36e-0458232C0087169
DiseaseDrug Withdrawal Symptoms

SMAD1 SMAD5

9.36e-0458232C0086189
DiseaseSubstance Withdrawal Syndrome

SMAD1 SMAD5

9.36e-0458232C0038587
Diseaseosteoarthritis, hip, osteoarthritis, knee

SMAD3 THSD7B

1.07e-0362232EFO_0004616, EFO_1000786
Diseaseasthma, age at onset

SMAD3 SMAD4

1.36e-0370232EFO_0004847, MONDO_0004979

Protein segments in the cluster

PeptideGeneStartEntry
GHQRPWWKVLPLSCF

CCSMST1

71

Q4G0I0
YWVKAELHRPWLLPV

ARRDC3

136

Q96B67
PWECYHLIWKILPYI

OR2T1

31

O43869
LWKNHRPWPALGRGY

LARGE1

281

O95461
RAWKWLRLPCHDFAP

MST1L

401

Q2TV78
PWIAGLWPALRKHFR

MTRR

141

Q9UBK8
RCYHLRHKVLPRWVW

IL27RA

541

Q6UWB1
PKGRWLWLDYVLVVP

LAMA5

1366

O15230
GKKCCRRWWILEPYP

DEFB130B

56

P0DP73
RHQRKYWCRLGPPRW

FCAMR

91

Q8WWV6
RPSLYLPVWWECGKH

CHD6

1566

Q8TD26
GKKCCRRWWILEPYP

DEFB130A

56

P0DP74
KKPRIVLPWWCVYVA

PKDREJ

1566

Q9NTG1
PHVIYARLWRWPDLH

SMAD4

91

Q13485
GIEPYCVKHWWVRLL

SHPRH

866

Q149N8
AWLRRYIKWPLLPPK

SUPV3L1

606

Q8IYB8
VLWPIWYRCRRPRHL

MRGPRX2

131

Q96LB1
CLSVLWPIWYRCRRP

MRGPRX4

121

Q96LA9
GLPHVIYCRVWRWPD

SMAD9

86

O15198
RKGLPHVIYCRVWRW

SMAD5

81

Q99717
KGLPHVIYCRVWRWP

SMAD1

81

Q15797
KGLPHVIYCRLWRWP

SMAD2

121

Q15796
KGLPHVIYCRLWRWP

SMAD3

81

P84022
KPYLPLHTNGRRWWK

VPS13C

361

Q709C8
PVYRWKPQKWSPCIL

THSD7B

796

Q9C0I4