Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	intra-Golgi vesicle-mediated transport	RAB6D RAB6B RAB6A RAB6C	7.43e-07	35	42	4	GO:0006891
GeneOntologyBiologicalProcess	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	RAB6D RAB6B RAB6A RAB6C	4.04e-06	53	42	4	GO:0006890
GeneOntologyBiologicalProcess	protein localization to Golgi membrane	RAB6B RAB6A	4.03e-05	5	42	2	GO:1903292
GeneOntologyBiologicalProcess	retrograde transport, endosome to Golgi	RAB6D RAB6B RAB6A RAB6C	7.08e-05	109	42	4	GO:0042147
GeneOntologyBiologicalProcess	cytosolic transport	RAB6D RAB6B RAB6A RAB6C	2.43e-04	150	42	4	GO:0016482
GeneOntologyCellularComponent	presynapse	SLC5A7 ATP6V1B1 EPS15L1 PTPRD CDH2 RAB6B PLEKHG5 HNRNPAB RAB6A IQSEC2	9.54e-06	886	43	10	GO:0098793
Domain	RRM_1	RBM28 RBM12B HNRNPAB PABPC4 NOL8	9.93e-05	208	42	5	PF00076
Domain	RRM	RBM28 RBM12B HNRNPAB PABPC4 NOL8	1.21e-04	217	42	5	SM00360
Domain	RRM_dom	RBM28 RBM12B HNRNPAB PABPC4 NOL8	1.50e-04	227	42	5	IPR000504
Domain	RRM	RBM28 RBM12B HNRNPAB PABPC4 NOL8	1.59e-04	230	42	5	PS50102
Domain	-	RBM28 RBM12B HNRNPAB PABPC4 NOL8	2.09e-04	244	42	5	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	RBM28 RBM12B HNRNPAB PABPC4 NOL8	2.71e-04	258	42	5	IPR012677
Domain	RAB	RAB6B RAB6A RAB6C	5.89e-04	73	42	3	PS51419
Domain	G_patch	TFIP11 CMTR1	1.21e-03	23	42	2	SM00443
Domain	G_patch_dom	TFIP11 CMTR1	1.21e-03	23	42	2	IPR000467
Domain	G-patch	TFIP11 CMTR1	1.21e-03	23	42	2	PF01585
Domain	G_PATCH	TFIP11 CMTR1	1.21e-03	23	42	2	PS50174
Domain	PH	ARHGEF16 PLEKHG5 DGKK IQSEC2	3.45e-03	278	42	4	SM00233
Domain	PH_DOMAIN	ARHGEF16 PLEKHG5 DGKK IQSEC2	3.49e-03	279	42	4	PS50003
Domain	Ras	RAB6B RAB6A RAB6C	3.52e-03	136	42	3	PF00071
Domain	PH_domain	ARHGEF16 PLEKHG5 DGKK IQSEC2	3.54e-03	280	42	4	IPR001849
Domain	Small_GTPase	RAB6B RAB6A RAB6C	5.55e-03	160	42	3	IPR001806
Domain	-	ATP6V1B1 MDN1 SMC5 RAB6B RAB6A RAB6C	6.12e-03	746	42	6	3.40.50.300
Domain	Small_GTP-bd_dom	RAB6B RAB6A RAB6C	6.24e-03	167	42	3	IPR005225
Domain	DH_1	ARHGEF16 PLEKHG5	8.84e-03	63	42	2	PS00741
Domain	RhoGEF	ARHGEF16 PLEKHG5	1.02e-02	68	42	2	SM00325
Domain	DH_2	ARHGEF16 PLEKHG5	1.08e-02	70	42	2	PS50010
Domain	RhoGEF	ARHGEF16 PLEKHG5	1.08e-02	70	42	2	PF00621
Domain	DH-domain	ARHGEF16 PLEKHG5	1.11e-02	71	42	2	IPR000219
Domain	-	ARHGEF16 PLEKHG5	1.11e-02	71	42	2	1.20.900.10
Domain	P-loop_NTPase	ATP6V1B1 MDN1 SMC5 RAB6B RAB6A RAB6C	1.12e-02	848	42	6	IPR027417
Domain	-	ARHGEF16 PLEKHG5 DGKK IQSEC2	1.13e-02	391	42	4	2.30.29.30
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	TFIP11 RBM28 CMTR1 RBM12B HNRNPAB PABPC4 NOL8	3.04e-07	347	45	7	16033648
Pubmed	RAB6 and dynein drive post-Golgi apical transport to prevent neuronal progenitor delamination.	CDH2 RAB6B RAB6A	4.42e-07	12	45	3	35979738
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	TFIP11 RAB6B HNRNPAB RAB6A PABPC4 NOL8	1.34e-06	271	45	6	32433965
Pubmed	BCAP31 drives TNBC development by modulating ligand-independent EGFR trafficking and spontaneous EGFR phosphorylation.	CDH2 RAB6B RAB6A	1.63e-06	18	45	3	31588230
Pubmed	Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.	RAB6A RAB6C	1.64e-06	2	45	2	11054569
Pubmed	Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is Essential for the Establishment of Neuronal Polarity and Brain Formation.	RAB6B RAB6A	1.64e-06	2	45	2	38830762
Pubmed	Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis.	RAB6B RAB6A RAB6C	3.52e-06	23	45	3	20360680
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	TFIP11 RBM28 MDN1 RAB6B RBM12B PCCB NACC1 HNRNPAB NOL8	4.14e-06	989	45	9	36424410
Pubmed	Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth.	RAB6B RAB6A	4.91e-06	3	45	2	25492866
Pubmed	Rab6 family proteins interact with the dynein light chain protein DYNLRB1.	RAB6B RAB6A	4.91e-06	3	45	2	18044744
Pubmed	A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6.	RAB6B RAB6A	4.91e-06	3	45	2	23737971
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	PARP14 RAB6B POLA1 HNRNPAB RAB6A PABPC4	4.93e-06	340	45	6	24332808
Pubmed	Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport.	RAB6B RAB6A	1.63e-05	5	45	2	11929610
Pubmed	ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.	RAB6B RAB6A	1.63e-05	5	45	2	32521280
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	EPS15L1 MDN1 PTPRD CDH2 NACC1 PATZ1 SPHKAP IQSEC2	2.92e-05	963	45	8	28671696
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	RBM28 MDN1 CDH2 PCCB HNRNPAB PABPC4	3.62e-05	484	45	6	31995728
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	SLC5A7 RBM28 MDN1 PARP14 NACC1 POLA1 IQSEC2	4.17e-05	736	45	7	29676528
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	RBM28 MDN1 SMC5 RBM12B HNRNPAB PABPC4 NOL8	5.06e-05	759	45	7	35915203
Pubmed	Protein Binder Toolbox for Studies of Solute Carrier Transporters.	RAB6D RAB6B RAB6A	5.35e-05	56	45	3	38878854
Pubmed	IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.	PCCB HNRNPAB PABPC4	5.94e-05	58	45	3	21642987
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	TFIP11 RBM28 CMTR1 PARP14 POLA1	7.79e-05	341	45	5	32971831
Pubmed	Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.	RAB6D RAB6B RAB6A	1.13e-04	72	45	3	16923123
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	TFIP11 RBM28 MDN1 HNRNPAB PATZ1 PABPC4	1.24e-04	605	45	6	28977666
Pubmed	Identification and characterization of multiple novel Rab-myosin Va interactions.	RAB6B RAB6A	1.47e-04	14	45	2	24006491
Pubmed	Cytoplasmic control of Rab family small GTPases through BAG6.	RAB6B RAB6A	1.70e-04	15	45	2	30804014
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	USP34 FNDC3A SMC5 STAB1	2.06e-04	225	45	4	12168954
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	TFIP11 EPS15L1 RBM28 SMC5 HNRNPAB PABPC4 NOL8	2.09e-04	954	45	7	36373674
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	USP34 TFIP11 EPS15L1 PTPRD PCCB RAB6A IQSEC2 STAB1	2.17e-04	1285	45	8	35914814
Pubmed	Apoptotic cells in mouse blastocysts are eliminated by neighbouring blastomeres.	CD93 STAB1	2.47e-04	18	45	2	33927296
Pubmed	Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation.	CDH2 ZIC1	2.47e-04	18	45	2	23817546
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CMTR1 SMC5 PCCB POLA1 PABPC4 NOL8	3.25e-04	724	45	6	36232890
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	USP34 SMC5 IQSEC2	3.46e-04	105	45	3	9628581
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	RBM12B HNRNPAB PATZ1 PABPC4	3.47e-04	258	45	4	37794589
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	USP34 MDN1 PARP14 PCCB	3.68e-04	262	45	4	36880596
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	RBM28 MDN1 CMTR1 POLA1 PABPC4 NOL8	4.04e-04	754	45	6	33060197
Pubmed	Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.	PCCB HNRNPAB RAB6A PABPC4	4.92e-04	283	45	4	28533407
Pubmed	Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.	RBM28 HNRNPAB PABPC4	5.24e-04	121	45	3	34029587
Pubmed	The functional interactome landscape of the human histone deacetylase family.	TFIP11 RBM28 MDN1 RBM12B	5.32e-04	289	45	4	23752268
Pubmed	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.	RBM28 MDN1 POLA1 PABPC4	5.97e-04	298	45	4	32353859
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	EPS15L1 AMER2 RAB6B PCCB HNRNPAB SPHKAP IQSEC2	6.06e-04	1139	45	7	36417873
Pubmed	Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.	HNRNPAB PABPC4	6.96e-04	30	45	2	15782174
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	TFIP11 RBM28 MDN1 HNRNPAB PABPC4 NOL8	7.43e-04	847	45	6	35850772
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MDN1 ARHGEF16 PATZ1 EDRF1 TESK2 IQSEC2	8.09e-04	861	45	6	36931259
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	FAM114A2 FNDC3A EPS15L1 ARHGEF16 RAB6A	8.14e-04	568	45	5	37774976
Pubmed	DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.	PTPRD ZIC1 STAB1	8.86e-04	145	45	3	21308776
Pubmed	Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.	EPS15L1 AMER2 BCAS1 RAB6B	9.85e-04	341	45	4	29791485
Pubmed	Molecular composition of IMP1 ribonucleoprotein granules.	HNRNPAB PABPC4	1.00e-03	36	45	2	17289661
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	RBM28 RBM12B PABPC4 NOL8	1.07e-03	349	45	4	25665578
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	ARHGEF16 PLEKHG5	1.12e-03	38	45	2	11756498
Pubmed	Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins.	LHCGR TFIP11	1.12e-03	38	45	2	23537643
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	FAM114A2 TFIP11 EPS15L1 NACC1 HNRNPAB NOL8	1.23e-03	934	45	6	33916271
Pubmed	Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.	HNRNPAB PABPC4	1.24e-03	40	45	2	23825951
Interaction	RAB6C interactions	RAB6B RAB6A RAB6C	1.15e-06	10	44	3	int:RAB6C
Cytoband	Xp11.22	DGKK IQSEC2	1.30e-03	54	45	2	Xp11.22
Cytoband	2q21.1	RAB6D RAB6C	1.50e-03	58	45	2	2q21.1
GeneFamily	RNA binding motif containing	RBM28 RBM12B HNRNPAB PABPC4 NOL8	3.93e-05	213	33	5	725
GeneFamily	RAB, member RAS oncogene GTPases	RAB6B RAB6A RAB6C	2.24e-04	65	33	3	388
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	TFIP11 CMTR1	7.29e-04	22	33	2	579
Disease	retinal degeneration (implicated_via_orthology)	RAB6D RAB6B PDHA2 RAB6A RAB6C	1.34e-09	33	44	5	DOID:8466 (implicated_via_orthology)
Disease	gait measurement	PTPRD PCCB PABPC4	1.46e-03	150	44	3	EFO_0007680
Disease	apolipoprotein A 1 measurement	LHCGR FAM114A2 FNDC3A CMTR1 PABPC4 STAB1	1.54e-03	848	44	6	EFO_0004614
Disease	urinary albumin to creatinine ratio	CDH2 SPHKAP STAB1	2.42e-03	179	44	3	EFO_0007778
Disease	antibody measurement	TPRG1 PTPRD	2.44e-03	49	44	2	EFO_0004556
Disease	triglycerides to total lipids in large LDL percentage	PCCB PABPC4	2.65e-03	51	44	2	EFO_0022331
Disease	cystatin C measurement	CD93 FNDC3A BCAS1 ARHGEF16	3.00e-03	402	44	4	EFO_0004617
Disease	triglycerides to total lipids in IDL percentage	PCCB PABPC4	4.01e-03	63	44	2	EFO_0022329

Protein segments in the cluster

Peptide	Gene	Start	Entry
RGSFGAMDDPFKNKA	EPS15L1	591	Q9UBC2
FKKRKSGGTMPSIFG	AMER2	71	Q8N7J2
KFSFKGMCRPLALGG	CD93	181	Q9NPY3
NQSYRAAMKGLGKPG	ARHGEF16	151	Q5VV41
PEGGKFDFGKHNMGS	RBM12B	891	Q8IXT5
PRKPDGKMRGFGFVQ	RBM28	146	Q9NW13
MSTGGDFGNPLRKFK	RAB6A	1	P20340
MSAGGDFGNPLRKFK	RAB6B	1	Q9NRW1
MSAGGDFGNPLRKFK	RAB6C	1	Q9H0N0
MSAGGDFGNPLRKFK	RAB6D	1	Q53S08
KVMRDPNGKSKGFGF	PABPC4	221	Q13310
KGGPEAGLSMFKNFA	DGKK	526	Q5KSL6
AGKKFRILATMNPGG	MDN1	1511	Q9NU22
RILATMNPGGDFGKK	MDN1	1516	Q9NU22
EKMHNGAFRGATGPK	LHCGR	211	P22888
GNSKKSKPFSSFGMA	EDRF1	96	Q3B7T1
GSLFGSKRGKGPFQM	IQSEC2	1206	Q5JU85
EGGNDPMSKKRRGEF	NOL8	196	Q76FK4
KRSNMPKLGGRSGFG	POLA1	666	P09884
RKANLLDSMFGSPGG	PATZ1	271	Q9HBE1
ADFGMAADKNKFPGD	PCCB	91	P05166
KLQMYFQSPKRSGGG	PARP14	26	Q460N5
RAANKMGFGPFSEKC	FNDC3A	736	Q9Y2H6
MRLKVGFQGGGCFRK	C19orf73	1	Q9NVV2
GDPGFKRTKGLMNRN	FAM114A2	191	Q9NRY5
MGRSPCFFKSFKGKL	FAM167A-AS1	1	Q96KT0
QSLGGFFKGLGPKRM	BCAS1	551	O75363
GPRFKKLADMYGGGD	CDH2	891	P19022
KGFGMTLKGPNDFKL	CMTR1	296	Q8N1G2
GPLQGYRLKFGRKDM	PTPRD	851	P23468
YKRGNFIPGLKVDGM	PDHA2	241	P29803
ILGGLFFAKPMRSKG	SLC5A7	96	Q9GZV3
MLGRVFNGSGKPIDK	ATP6V1B1	121	P15313
MYSKQDKGGVRPGLF	SPHKAP	791	Q2M3C7
KMDPNTGRSRGFGFI	HNRNPAB	101	Q99729
LQPGDFLKGFKMFGS	PLEKHG5	416	O94827
KEFLRGNGLAAGKMN	SLFN12L	6	Q6IEE8
RKNGMIGLSDFFFPK	ROPN1L	201	Q96C74
FTFPGMSLDKRQGEG	TPRG1	151	Q6ZUI0
ARGKPMGFGFSAFQA	STAB1	2501	Q9NY15
GINPFADGMGAFKLN	ZIC1	36	Q15915
MAALTGGKGFPFLFQ	USP34	2541	Q70CQ2
PFSARQDLMGGKIKF	TESK2	401	Q96S53
GLAGKPAFMGRADKV	SMC5	96	Q8IY18
KPSQKGFAGGTKSFM	TFIP11	126	Q9UBB9
GGNGSRKMAKFSTPD	NACC1	196	Q96RE7