Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	nuclear speck	PDX1 SETD1A PATL1 TCERG1	1.37e-03	431	24	4	GO:0016607
GeneOntologyCellularComponent	chromatin	DVL3 SOX3 PDX1 SETD1A GBX2 FOXB2	5.54e-03	1480	24	6	GO:0000785
Domain	Shisa	SHISA4 SHISA5	5.67e-05	9	24	2	IPR026910
Domain	Shisa	SHISA4 SHISA5	5.67e-05	9	24	2	PF13908
Domain	RRM_1	SETD1A SCAF4 CPSF7	2.32e-03	208	24	3	PF00076
Domain	RRM	SETD1A SCAF4 CPSF7	2.61e-03	217	24	3	SM00360
Domain	RRM_dom	SETD1A SCAF4 CPSF7	2.97e-03	227	24	3	IPR000504
Domain	RRM	SETD1A SCAF4 CPSF7	3.08e-03	230	24	3	PS50102
Domain	-	SETD1A SCAF4 CPSF7	3.64e-03	244	24	3	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	SETD1A SCAF4 CPSF7	4.25e-03	258	24	3	IPR012677
Domain	Homeobox_metazoa	PDX1 GBX2	5.92e-03	90	24	2	IPR020479
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	DVL3 PATL1 WIPF2 DROSHA SCAF4 CPSF7	9.58e-09	220	25	6	24550385
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	TCERG1 WIPF2 CCNK SCAF4 CPSF7	7.89e-08	154	25	5	16055720
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SETD1A TNIP1 TCERG1 CCNK PRRC2C TAB3 SCAF4	8.83e-08	549	25	7	38280479
Pubmed	A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.	SETD1A TCERG1 CCNK	2.66e-07	18	25	3	29474905
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SETD1A CCNK PRRC2C SCAF4 CPSF7	8.88e-07	251	25	5	31076518
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	SETD1A TCERG1 CCNK CPSF7	2.50e-06	134	25	4	25452129
Pubmed	PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region.	SOX3 PDX1	2.97e-06	4	25	2	19799567
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	PATL1 TCERG1 WIPF2 CCNK DROSHA PRRC2C SCAF4 CPSF7	3.39e-06	1371	25	8	36244648
Pubmed	Human transcription factor protein interaction networks.	SETD1A TNIP1 PATL1 TCERG1 PRRC2C TAB3 SCAF4 CPSF7	4.61e-06	1429	25	8	35140242
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	DVL3 TNIP1 PATL1 NUMBL DROSHA BTBD7 SH3BP2	6.20e-06	1038	25	7	26673895
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	DVL3 PATL1 NUMBL PRRC2C	1.65e-05	216	25	4	31519766
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	PATL1 TCERG1 DROSHA PRRC2C SCAF4 CPSF7	1.86e-05	807	25	6	22681889
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	TCERG1 WIPF2 CCNK SCAF4 CPSF7	2.67e-05	506	25	5	30890647
Pubmed	Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings.	SHISA4 SHISA5	5.18e-05	15	25	2	17481602
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	TNIP1 TCERG1 DROSHA PRRC2C CPSF7	5.45e-05	588	25	5	38580884
Pubmed	A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis.	SOX3 PDX1	8.42e-05	19	25	2	34686326
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PATL1 TCERG1 DROSHA PRRC2C MAN1B1	8.75e-05	650	25	5	38777146
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	TCERG1 NUMBL CCNK DROSHA SCAF4 CPSF7	9.53e-05	1082	25	6	38697112
Pubmed	Expression of Sox transcription factors in the developing mouse pancreas.	SOX3 PDX1	1.03e-04	21	25	2	12815626
Pubmed	Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1.	SOX3 GBX2	1.03e-04	21	25	2	16109395
Pubmed	Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC.	TNIP1 TAB3	1.14e-04	22	25	2	36098982
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	WIPF2 PRRC2C SCAF4 CPSF7	1.20e-04	360	25	4	33111431
Pubmed	Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.	SOX3 GBX2	1.60e-04	26	25	2	22992956
Pubmed	SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes.	TNIP1 TAB3	2.28e-04	31	25	2	27307491
Pubmed	Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis.	DVL3 PDX1	2.43e-04	32	25	2	23177622
Pubmed	ZNF212 promotes genomic integrity through direct interaction with TRAIP.	TNIP1 TAB3	3.25e-04	37	25	2	36594163
Pubmed	ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB.	TNIP1 SCAF4	4.61e-04	44	25	2	34839354
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	TCERG1 NUMBL CCNK PRRC2C SCAF4	4.69e-04	934	25	5	33916271
Pubmed	Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain.	SOX3 GBX2	4.82e-04	45	25	2	17687036
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	TCERG1 CCNK PRRC2C SCAF4 CPSF7	5.17e-04	954	25	5	36373674
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TCERG1 NUMBL CCNK DROSHA MAN1B1 SCAF4	5.51e-04	1497	25	6	31527615
Pubmed	Genome-wide atlas of gene expression in the adult mouse brain.	GBX2 FOXB2	6.94e-04	54	25	2	17151600
Interaction	YAP1 interactions	SETD1A TCERG1 SHISA4 CCNK DROSHA PRRC2C TAB3 SCAF4 CPSF7	1.63e-06	1095	23	9	int:YAP1
Interaction	QPRT interactions	PATL1 PRRC2C SCAF4 CPSF7	2.34e-06	84	23	4	int:QPRT
Interaction	WWOX interactions	DVL3 PATL1 TCERG1 WIPF2 DROSHA SCAF4 CPSF7	4.33e-06	627	23	7	int:WWOX
Interaction	CELF1 interactions	PATL1 TCERG1 PRRC2C SCAF4 CPSF7	1.57e-05	288	23	5	int:CELF1
Interaction	TCERG1 interactions	SETD1A TNIP1 TCERG1 WIPF2	8.21e-05	207	23	4	int:TCERG1
Interaction	ATG13 interactions	TNIP1 TCERG1 PRRC2C TAB3	8.37e-05	208	23	4	int:ATG13
Interaction	WWTR1 interactions	DVL3 TNIP1 TCERG1 PRRC2C TAB3	9.69e-05	422	23	5	int:WWTR1
Interaction	ACTC1 interactions	TNIP1 TCERG1 WIPF2 CCNK SCAF4 CPSF7	9.97e-05	694	23	6	int:ACTC1
Interaction	CEP76 interactions	DVL3 TCERG1 CCNK PRRC2C	1.00e-04	218	23	4	int:CEP76
Interaction	RAD18 interactions	SETD1A CCNK PRRC2C SCAF4 CPSF7	1.41e-04	457	23	5	int:RAD18
Interaction	LUC7L interactions	TNIP1 TCERG1 SCAF4 CPSF7	1.50e-04	242	23	4	int:LUC7L
Interaction	SNRPA interactions	TNIP1 TCERG1 PRRC2C SCAF4 CPSF7	1.81e-04	482	23	5	int:SNRPA
Interaction	WBP4 interactions	TCERG1 SCAF4 CPSF7	2.52e-04	109	23	3	int:WBP4
GeneFamily	Shisa family members	SHISA4 SHISA5	2.32e-05	8	17	2	742
GeneFamily	RNA binding motif containing	SETD1A SCAF4 CPSF7	9.70e-04	213	17	3	725
GeneFamily	HOXL subclass homeoboxes	PDX1 GBX2	1.07e-03	52	17	2	518
Coexpression	GSE22935_UNSTIM_VS_24H_MBOVIS_BCG_STIM_MACROPHAGE_UP	SOX3 SH3BP2 MAN1B1 CPSF7	3.10e-05	200	24	4	M7754
Drug	Intramine	DOCK3 TNIP1	1.06e-06	2	24	2	CID000014358
Drug	Pindolol [13523-86-9]; Down 200; 16.2uM; MCF7; HT_HG-U133A	DVL3 SOX3 BTBD7 SH3BP2 SCAF4	1.63e-06	195	24	5	6834_DN
Drug	Acetylsalicylsalicylic acid [530-75-6]; Down 200; 13.4uM; MCF7; HT_HG-U133A	SOX3 SETD1A SH3BP2 MAN1B1	4.85e-05	195	24	4	2223_DN
Drug	Pregnenolone [145-13-1]; Down 200; 12.6uM; MCF7; HT_HG-U133A	DVL3 SETD1A SH3BP2 SCAF4	4.95e-05	196	24	4	4802_DN
Drug	Kynurenine, 3-hydroxy (R,S) [2147-61-7]; Up 200; 17.8uM; MCF7; HT_HG-U133A	SETD1A WIPF2 SH3BP2 SCAF4	5.04e-05	197	24	4	5276_UP
Drug	Bumetanide [28395-03-1]; Down 200; 11uM; MCF7; HT_HG-U133A	SETD1A WIPF2 BTBD7 SH3BP2	5.04e-05	197	24	4	7440_DN
Drug	Carbachol [51-83-2]; Down 200; 21.8uM; MCF7; HT_HG-U133A	SETD1A CCNK BTBD7 SCAF4	5.35e-05	200	24	4	3380_DN
Disease	hepatocyte growth factor-like protein measurement	DOCK3 SHISA5	4.75e-04	38	25	2	EFO_0008154
Disease	thioredoxin domain-containing protein 12 measurement	DOCK3 SHISA5	5.01e-04	39	25	2	EFO_0008298
Disease	daytime rest measurement	TNIP1 SHISA4 PRRC2C	1.93e-03	295	25	3	EFO_0007828
Disease	lung adenocarcinoma	TNIP1 NUMBL	9.49e-03	174	25	2	EFO_0000571

Protein segments in the cluster

Peptide	Gene	Start	Entry
DALMHPPAYPPPPVP	SH3BP2	196	P78314
LPHRPPPPPPSSYMT	CCNK	416	O75909
LPYHPHVYPPNPPPP	CCNK	471	O75909
PWPMAFPYQYPPPPH	DVL3	531	Q92997
LPPPHMQPPFVPAYP	NUMBL	481	Q9Y6R0
PPPPGIHYQHLMPPP	CPSF7	256	Q8N684
PKPVHVRPPMPPRYP	PATL1	211	Q86TB9
PPPPPPPPPHMVHYF	FOXB2	166	Q5VYV0
LYMGRQPPPPPPHPF	PDX1	36	P52945
VMYPPPPPPPHRDFI	MAN1B1	36	Q9UKM7
DRMVPPPPPPHHLYA	PRTG	716	Q2VWP7
MFMPYRPVVLPPPPP	GBX2	46	P52951
DPMDPPALPPKPYHP	DOCK3	1966	Q8IZD9
FVAFHPPLPPPPPPY	BTBD7	751	Q9P203
PPPFLRPGFNPMHLP	SCAF4	721	O95104
PPPHLQRFPLMPPRP	SCAF4	866	O95104
FLPPRPDFVPFPPPM	DROSHA	71	Q9NRR4
PPPPALPPMHRYDMA	SOX3	291	P41225
SPPPPPPSYMHIPRY	TAB3	176	Q8N5C8
PPPHRPLYQPMQPHP	PRRC2C	711	Q9Y520
PPVYNPAAPPPYMPP	SHISA4	176	Q96DD7
PPPYPAQPMGPPAYH	SHISA5	196	Q8N114
YPPPPPPPPHIYDFV	SETD1A	646	O15047
RYPPPPMAMEHPPPL	TNIP1	571	Q15025
LPVPHPFPHPPPFPM	TEX13D	221	A0A0J9YY54
PFPHPPPFPMKFPSL	TEX13D	226	A0A0J9YY54
PPHLQRPPFMPPPMS	TCERG1	91	O14776
PPPPPYRMHGSEPPS	WIPF2	341	Q8TF74