Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	NFXL1 ZNF771 ZFP14 ZFHX3 ZNF630 ZNF777 ZNF140 ZNF672 IKZF2 ZBTB48 ZNF732 ZNF354B ZNF440 IKZF5	9.44e-10	1459	27	14	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	NFXL1 ZNF771 ZFP14 ZFHX3 ZNF630 ZNF777 ZNF140 ZNF672 ZBTB48 ZNF732 ZNF354B ZNF440 IKZF5	8.22e-09	1412	27	13	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF771 ZFP14 ZFHX3 ZNF630 ZNF140 IKZF2 ZBTB48 ZNF732 ZNF354B IKZF5	2.70e-06	1244	27	10	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF771 ZFP14 ZFHX3 ZNF630 ZNF140 IKZF2 ZBTB48 ZNF732 ZNF354B IKZF5	3.27e-06	1271	27	10	GO:0000987
Domain	-	ZNF771 ZFP14 ZFHX3 ZNF630 ZNF777 ZNF140 ZNF672 IKZF2 ZBTB48 ZNF732 ZNF354B ZNF440 IKZF5	2.17e-12	679	27	13	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF771 ZFP14 ZFHX3 ZNF630 ZNF777 ZNF140 ZNF672 IKZF2 ZBTB48 ZNF732 ZNF354B ZNF440 IKZF5	2.86e-12	694	27	13	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF771 ZFP14 ZFHX3 ZNF630 ZNF777 ZNF140 ZNF672 IKZF2 ZBTB48 ZNF732 ZNF354B ZNF440 IKZF5	1.15e-11	775	27	13	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF771 ZFP14 ZFHX3 ZNF630 ZNF777 ZNF140 ZNF672 IKZF2 ZBTB48 ZNF732 ZNF354B ZNF440 IKZF5	1.18e-11	777	27	13	PS00028
Domain	Znf_C2H2-like	ZNF771 ZFP14 ZFHX3 ZNF630 ZNF777 ZNF140 ZNF672 IKZF2 ZBTB48 ZNF732 ZNF354B ZNF440 IKZF5	1.60e-11	796	27	13	IPR015880
Domain	Znf_C2H2	ZNF771 ZFP14 ZFHX3 ZNF630 ZNF777 ZNF140 ZNF672 IKZF2 ZBTB48 ZNF732 ZNF354B ZNF440 IKZF5	1.85e-11	805	27	13	IPR007087
Domain	ZnF_C2H2	ZNF771 ZFP14 ZFHX3 ZNF630 ZNF777 ZNF140 ZNF672 IKZF2 ZBTB48 ZNF732 ZNF354B ZNF440 IKZF5	1.93e-11	808	27	13	SM00355
Domain	zf-C2H2	ZNF771 ZFP14 ZFHX3 ZNF630 ZNF777 ZNF140 ZNF672 IKZF2 ZBTB48 ZNF732 ZNF354B ZNF440	6.46e-11	693	27	12	PF00096
Domain	zf-C2H2_6	ZNF771 ZFP14 ZNF140 ZNF672 ZBTB48 ZNF732 ZNF354B ZNF440	9.82e-09	314	27	8	PF13912
Domain	KRAB	ZFP14 ZNF630 ZNF777 ZNF140 ZNF732 ZNF354B ZNF440	5.72e-07	358	27	7	PS50805
Domain	KRAB	ZFP14 ZNF630 ZNF777 ZNF140 ZNF732 ZNF354B ZNF440	5.72e-07	358	27	7	PF01352
Domain	KRAB	ZFP14 ZNF630 ZNF777 ZNF140 ZNF732 ZNF354B ZNF440	7.01e-07	369	27	7	SM00349
Domain	KRAB	ZFP14 ZNF630 ZNF777 ZNF140 ZNF732 ZNF354B ZNF440	7.14e-07	370	27	7	IPR001909
Domain	DHHC	KMT2C ZDHHC3	5.92e-04	25	27	2	PS50216
Domain	Znf_DHHC_palmitoyltrfase	KMT2C ZDHHC3	5.92e-04	25	27	2	IPR001594
Domain	Znf_FYVE_PHD	KMT2C PHF23 RUFY4	1.22e-03	147	27	3	IPR011011
Domain	-	KMT2C PHF23 MUL1 RUFY4	3.73e-03	449	27	4	3.30.40.10
Domain	Znf_RING/FYVE/PHD	KMT2C PHF23 MUL1 RUFY4	4.04e-03	459	27	4	IPR013083
Domain	PHD	KMT2C PHF23	5.23e-03	75	27	2	PF00628
Domain	Znf_PHD-finger	KMT2C PHF23	5.79e-03	79	27	2	IPR019787
Domain	PHD	KMT2C PHF23	7.29e-03	89	27	2	SM00249
Domain	Znf_PHD	KMT2C PHF23	7.61e-03	91	27	2	IPR001965
Domain	ZF_PHD_2	KMT2C PHF23	8.27e-03	95	27	2	PS50016
Domain	ZF_PHD_1	KMT2C PHF23	8.44e-03	96	27	2	PS01359
Domain	ZF_RING_2	NFXL1 KMT2C MUL1	8.86e-03	298	27	3	PS50089
Domain	Znf_RING	NFXL1 KMT2C MUL1	1.13e-02	326	27	3	IPR001841
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF771 KMT2C ZFP14 ZFHX3 ZNF777 ZNF140 ZNF732 ZNF354B ZNF440	5.08e-06	1387	16	9	M734
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	KMT2C ZFP14 ZFHX3 ZNF777 IKZF2 FHL3 ZDHHC3	8.84e-07	709	27	7	22988430
Pubmed	Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.	IKZF2 IKZF5	5.80e-06	5	27	2	10978333
Pubmed	Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos.	IKZF2 IKZF5	2.08e-05	9	27	2	22638570
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZFHX3 IKZF2 ZBTB48 PHF23 ZDHHC3 IKZF5	3.01e-05	808	27	6	20412781
Pubmed	Transcriptional mechanisms of EphA7 gene expression in the developing cerebral cortex.	IKZF2 EPHA5	3.18e-05	11	27	2	21940705
Pubmed	Ikaros confers early temporal competence to mouse retinal progenitor cells.	IKZF2 IKZF5	4.50e-05	13	27	2	18940586
Pubmed	Ikaros promotes early-born neuronal fates in the cerebral cortex.	IKZF2 IKZF5	9.84e-05	19	27	2	23382203
Pubmed	Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons.	IKZF2 IKZF5	1.45e-04	23	27	2	28289129
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF140 ZNF354B ZNF440	3.70e-04	181	27	3	37372979
Pubmed	Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.	NFXL1 ZFHX3	4.01e-04	38	27	2	28218735
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	ZC3H14 KMT2C ZBTB48 FHL3	4.48e-04	469	27	4	27634302
Pubmed	Human transcription factor protein interaction networks.	XRN1 ZNF771 KMT2C ZFHX3 PHF23 IKZF5	6.70e-04	1429	27	6	35140242
Pubmed	A screen for downstream effectors of Neurogenin2 in the embryonic neocortex.	IKZF5 EPHA5	7.51e-04	52	27	2	15328020
Interaction	NOTCH2 interactions	ZNF771 ZNF777 ZNF672 ZBTB48 TMEM9B EPHA5	1.33e-05	423	26	6	int:NOTCH2
Interaction	ZBTB48 interactions	ZNF771 ZNF777 ZBTB48 TNFRSF14	4.75e-05	158	26	4	int:ZBTB48
Cytoband	7q36.1	KMT2C ZNF777	8.76e-04	74	27	2	7q36.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7q36	KMT2C ZNF777	3.95e-03	159	27	2	chr7q36
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	ZBTB48 MUL1 TNFRSF14	7.29e-03	681	27	3	chr1p36
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF771 ZFP14 ZFHX3 ZNF630 ZNF777 ZNF140 ZNF672 IKZF2 ZBTB48 ZNF732 ZNF354B ZNF440 IKZF5	4.35e-13	718	23	13	28
GeneFamily	PHD finger proteins	KMT2C PHF23	5.79e-03	90	23	2	88
Coexpression	GSE14000_UNSTIM_VS_4H_LPS_DC_UP	ZC3H14 ZNF630 ZNF672 ZBTB48 PHF23	1.61e-06	197	27	5	M3345
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PKHD1 NFXL1 KMT2C ZFHX3	4.61e-06	186	27	4	23b8d51d20b05795a73892d3e20e0f9b6a207820
Disease	lung adenocarcinoma (is_implicated_in)	KMT2C ZFHX3	7.91e-04	49	25	2	DOID:3910 (is_implicated_in)
Disease	orofacial cleft, sex interaction measurement	ZFHX3 ZNF672	2.41e-03	86	25	2	EFO_0008343, MONDO_0000358
Disease	sodium measurement	PKHD1 ZNF771	3.44e-03	103	25	2	EFO_0009282
Disease	tea consumption measurement	PKHD1 ZFHX3	5.33e-03	129	25	2	EFO_0010091
Disease	lung non-small cell carcinoma (is_implicated_in)	KMT2C ZFHX3	6.16e-03	139	25	2	DOID:3908 (is_implicated_in)
Disease	severe acute respiratory syndrome, COVID-19	ZFHX3 IKZF2 ZNF732	6.20e-03	447	25	3	EFO_0000694, MONDO_0100096
Disease	lung non-small cell carcinoma (is_marker_for)	ZFHX3 IKZF2	8.97e-03	169	25	2	DOID:3908 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
CVCEKDYFRRESDPP	EPHA5	336	P54756
KPDPVPKDYRKCCFC	KMT2C	4391	Q8NEZ4
DCPWPCPKCRFEYKR	NFXL1	211	Q6ZNB6
CPKCRFEYKRSETPS	NFXL1	216	Q6ZNB6
CSCTECYRALPEPKK	MUL1	321	Q969V5
KPFKCPFCSYACRRR	IKZF2	166	Q9UKS7
KPYKCELCSFRCSDR	IKZF5	136	Q9H5V7
EKYRDCERFKCPCPT	POLA1	1271	P09884
VPCYENKFAPRCARC	FHL3	151	Q13643
DYKKRDRCCPPCAQG	RUFY4	551	Q6ZNE9
CPELDCASPRKYLFK	PKHD1	3341	P08F94
EKPFECPKCGKCYFR	ZBTB48	316	P10074
CKECGKAFTCPRYVR	ZNF440	286	Q8IYI8
ERPYECPECDKRFSA	ZNF771	116	Q7L3S4
NFEDVRCKCICPPYK	TMEM9B	36	Q9NQ34
VYKCPKCCSIKPDRA	ZDHHC3	126	Q9NYG2
EKPYRCELCGKRFTC	ZNF672	336	Q499Z4
PEKFPAIERCCTRYK	XRN1	616	Q8IZH2
PDFFYCQKCKELRPE	PHF23	376	Q9BUL5
REKPFECSECRKAFC	ZNF630	371	Q2M218
KTPYECNECRKAFRC	ZNF140	326	P52738
SECCPKCSPGYRVKE	TNFRSF14	51	Q92956
PYECKECRKPFRLLS	ZFP14	451	Q9HCL3
ERPYKCNECDKTFRC	ZNF354B	491	Q96LW1
EKPYRCEECGKAFLC	ZNF732	471	B4DXR9
ERPYTCPECKKSFRL	ZNF777	661	Q9ULD5
LCRYFPACKKMECPF	ZC3H14	681	Q6PJT7
EKFLDPSRPYKCTVC	ZFHX3	1536	Q15911