Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of nuclear pore	NDC1 NPAP1 POM121B	3.07e-05	25	49	3	GO:0017056
Domain	TF_fork_head_CS_2	FOXO1 FOXN4 FOXB2	1.97e-04	46	46	3	IPR030456
Domain	TF_fork_head_CS_1	FOXO1 FOXN4 FOXB2	2.10e-04	47	46	3	IPR018122
Domain	FORK_HEAD_3	FOXO1 FOXN4 FOXB2	2.38e-04	49	46	3	PS50039
Domain	FH	FOXO1 FOXN4 FOXB2	2.38e-04	49	46	3	SM00339
Domain	FORK_HEAD_1	FOXO1 FOXN4 FOXB2	2.38e-04	49	46	3	PS00657
Domain	FORK_HEAD_2	FOXO1 FOXN4 FOXB2	2.38e-04	49	46	3	PS00658
Domain	Forkhead	FOXO1 FOXN4 FOXB2	2.38e-04	49	46	3	PF00250
Domain	Fork_head_dom	FOXO1 FOXN4 FOXB2	2.38e-04	49	46	3	IPR001766
Domain	-	FOXO1 FOXN4 FOXB2 E2F8	2.01e-03	218	46	4	1.10.10.10
Domain	WHTH_DNA-bd_dom	FOXO1 FOXN4 FOXB2 E2F8	2.93e-03	242	46	4	IPR011991
Domain	-	POLA1 NYNRIN	5.98e-03	47	46	2	3.30.420.10
Domain	ARM-type_fold	GBF1 NBEAL2 EIF4G2 ULK4	9.55e-03	339	46	4	IPR016024
Domain	RNaseH-like_dom	POLA1 NYNRIN	1.25e-02	69	46	2	IPR012337
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	FOXO1 GBF1 GSE1 PUF60 EPC1 RBM26 PER1 EIF5B ASXL2 MGA	2.70e-07	857	49	10	25609649
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USF3 TOX4 GBF1 PER1 EIF5B PEAK1 MGA POM121B	4.17e-07	493	49	8	15368895
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	TOX4 NDC1 GSE1 SBNO1 POLA1 RBM26 EIF5B	4.94e-07	341	49	7	32971831
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	DCDC1 GSE1 ZNF608 ATXN7L1 EPC1 PER1 ZZEF1 MGA PHLDB2 INO80E	2.93e-06	1116	49	10	31753913
Pubmed	Interaction network of human early embryonic transcription factors.	GSE1 ZNF608 EPC1 ASXL2 MGA INO80E	9.82e-06	351	49	6	38297188
Pubmed	TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver.	FOXO1 TOX4	1.16e-05	4	49	2	34914893
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	GSE1 ZNF608 EPC1 RBM26 MGA	3.78e-05	268	49	5	33640491
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	EPC1 RBM26 EIF5B BCAR3 ITGB4 PHLDB2	7.33e-05	503	49	6	16964243
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	TOX4 GSE1 SBNO1 EPC1 MGA	1.15e-04	339	49	5	30415952
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	MAP6 EIF4G2 DGKZ ASXL2 PEAK1 MGA ITGB4 E2F8	1.26e-04	1084	49	8	11544199
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	GBF1 PUF60 NBEAL2 EMID1 PER1 ULK4 ZZEF1 ITGB4	1.44e-04	1105	49	8	35748872
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	GBF1 NDC1 SBNO1 PUF60 POLA1 EIF4G2 RBM26 EIF5B PEAK1	1.48e-04	1425	49	9	30948266
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	CACNB1 TOX4 KIAA1549L PUF60 NYNRIN ITGB4	2.06e-04	608	49	6	16713569
Pubmed	Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain.	FOXO1 FOXB2	2.30e-04	16	49	2	16376864
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXO1 USF3 TOX4 FOXN4 MGA ATF6B E2F8	2.67e-04	908	49	7	19274049
Pubmed	Isoform-specific GSK3A activity is negatively correlated with human sperm motility.	SBNO1 C10orf90 CPZ	3.02e-04	92	49	3	30824926
Pubmed	A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.	MAK NDC1 EIF5B PHLDB2 INO80E	3.06e-04	419	49	5	28700943
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	GEMIN7 SBNO1 POLA1 EPC1	3.79e-04	242	49	4	34011540
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	GBF1 POLA1 EIF4G2 RBM26 ASXL2 MGA	4.01e-04	689	49	6	36543142
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	SBNO1 POLA1 EPC1 NPAP1 RBM26 C10orf90 ATP13A3 MGA	4.93e-04	1327	49	8	32694731
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	FOXO1 TOX4 FOXN4 PER1	5.18e-04	263	49	4	20932939
Pubmed	BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility.	GSE1 ZNF608	5.26e-04	24	49	2	33722704
Pubmed	A human MAP kinase interactome.	USF3 TOX4 KIAA1549L MGA ITGB4	6.00e-04	486	49	5	20936779
Pubmed	mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation.	FOXO1 ITGB4	6.67e-04	27	49	2	27807348
Pubmed	The protein kinase complement of the human genome.	ULK4 PEAK1	7.18e-04	28	49	2	12471243
Pubmed	Identification of the COMM-domain containing protein 1 as specific binding partner for the guanine-rich RNA sequence binding factor 1.	GSE1 MAP6	8.25e-04	30	49	2	32645484
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	SBNO1 PUF60 RBM26	8.29e-04	130	49	3	35545047
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	GSE1 PUF60 EIF4G2 RBM26 EIF5B ASXL2 E2F8	8.50e-04	1103	49	7	34189442
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	FOXO1 TOX4 RBM26 MGA ATF6B DOP1B	9.22e-04	808	49	6	20412781
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TOX4 PUF60 RBM26 PEAK1 MGA	1.04e-03	549	49	5	38280479
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	AFF2 EPC1 ULK4 CPZ MUC3A	1.06e-03	552	49	5	10737800
Pubmed	Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase.	TOX4 MGA ITGB4	1.21e-03	148	49	3	22898364
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FOXO1 GBF1 PEAK1 E2F8 PHLDB2 DOP1B	1.28e-03	861	49	6	36931259
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	GSE1 ZNF608 ATP13A3	1.30e-03	152	49	3	38360978
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	NDC1 POM121B	1.32e-03	38	49	2	12791264
Interaction	FOXK2 interactions	PUF60 RBM26 PER1 EIF5B ASXL2 DOP1B	1.50e-05	225	48	6	int:FOXK2
Cytoband	3q13.2	USF3 PHLDB2	5.09e-04	31	49	2	3q13.2
GeneFamily	Forkhead boxes	FOXO1 FOXN4 FOXB2	3.52e-05	43	27	3	508
Drug	Sulmazole [73384-60-8]; Down 200; 14uM; HL60; HT_HG-U133A	FOXO1 CACNB1 MAK PER1 DOP1B	5.56e-05	195	48	5	2153_DN
Drug	Clemizole hydrochloride [1163-36-6]; Up 200; 11uM; PC3; HT_HG-U133A	ATXN7L1 EMID1 EIF4G2 NPAP1 PER1	5.70e-05	196	48	5	7371_UP
Drug	Retinoic acid [302-79-4]; Up 200; 13.4uM; PC3; HT_HG-U133A	CACNB1 AFF2 EMID1 RBM26 ITGB4	5.70e-05	196	48	5	5767_UP
Drug	CP-690334-01 [459212-38-5]; Up 200; 1uM; PC3; HT_HG-U133A	CACNB1 MAK AFF2 EMID1 ZZEF1	5.70e-05	196	48	5	3826_UP
Drug	Natamycin [7681-93-8]; Up 200; 6uM; HL60; HT_HG-U133A	GEMIN7 PER1 BCAR3 ZZEF1 ITGB4	5.83e-05	197	48	5	6126_UP
Drug	CP-944629 [668990-94-1]; Up 200; 10uM; PC3; HT_HG-U133A	CACNB1 NBEAL2 NYNRIN EMID1 PER1	5.98e-05	198	48	5	7549_UP
Drug	Primidone [125-33-7]; Down 200; 18.4uM; MCF7; HT_HG-U133A	NYNRIN EMID1 EIF4G2 PER1 ITGB4	5.98e-05	198	48	5	3402_DN
Drug	Sulfabenzamide [127-71-9]; Down 200; 14.4uM; HL60; HT_HG-U133A	FOXO1 CACNB1 AFF2 PER1 ITGB4	5.98e-05	198	48	5	2159_DN
Drug	Esculin Hydrate [531-75-9]; Up 200; 11.8uM; HL60; HT_HG-U133A	FOXO1 CACNB1 GEMIN7 AFF2 ZZEF1	6.12e-05	199	48	5	3052_UP
Drug	Yohimbinic acid monohydrate [27801-27-2]; Down 200; 11.2uM; HL60; HT_HG-U133A	FOXO1 CACNB1 AFF2 RBM26 ITGB4	6.12e-05	199	48	5	2147_DN
Drug	Austricine [10180-88-8]; Down 200; 14.2uM; HL60; HT_HG-U133A	CACNB1 AFF2 NBEAL2 PER1 DOP1B	6.27e-05	200	48	5	2157_DN
Drug	ICI182,780; Up 200; 1uM; MCF7; HT_HG-U133A	NYNRIN EMID1 PER1 ITGB4 DOP1B	6.27e-05	200	48	5	7534_UP
Disease	feeling nervous measurement	MGA ATF6B INO80E	4.14e-04	87	49	3	EFO_0009597
Disease	diastolic blood pressure, unipolar depression	EIF4G2 ULK4	1.14e-03	30	49	2	EFO_0003761, EFO_0006336
Disease	platelet component distribution width	TOX4 GSE1 NYNRIN EPC1 ATP13A3 ZZEF1	1.51e-03	755	49	6	EFO_0007984
Disease	pulse pressure measurement, diastolic blood pressure, systolic blood pressure, hypertension	GSE1 ULK4	1.55e-03	35	49	2	EFO_0000537, EFO_0005763, EFO_0006335, EFO_0006336
Disease	Parkinson's disease (implicated_via_orthology)	FOXO1 EIF4G2 ATP13A3	2.28e-03	157	49	3	DOID:14330 (implicated_via_orthology)
Disease	ocular hypertension, response to triamcinolone acetonide	OTOGL ITGB4	3.02e-03	49	49	2	EFO_0006954, EFO_1001069
Disease	body weight	FOXO1 USF3 TOX4 GSE1 ULK4 ZZEF1 MGA	4.58e-03	1261	49	7	EFO_0004338
Disease	Abnormality of refraction	ZNF608 ULK4 CPZ PEAK1 ZZEF1	5.07e-03	673	49	5	HP_0000539
Disease	venous thromboembolism, fibrinogen measurement	SBNO1 DGKZ	5.58e-03	67	49	2	EFO_0004286, EFO_0004623
Disease	eye morphology measurement	ATXN7L1 EIF4G2 ULK4	5.71e-03	218	49	3	EFO_0007858
Disease	schizophrenia (implicated_via_orthology)	SBNO1 MAP6	5.74e-03	68	49	2	DOID:5419 (implicated_via_orthology)
Disease	biological sex	DCDC1 SBNO1 PEAK1	6.61e-03	230	49	3	PATO_0000047
Disease	chronic kidney disease	DCDC1 ATXN7L1 FOXB2	7.02e-03	235	49	3	EFO_0003884
Disease	otosclerosis	MAK PEAK1	8.05e-03	81	49	2	EFO_0004213

Protein segments in the cluster

Peptide	Gene	Start	Entry
QPMKPTYAIPIIPIT	EPC1	291	Q9H2F5
PVPLMTPTQQKRVIP	nan	376	Q9N2K0
PVPLMTLTPQKRVIP	nan	376	Q9N2J8
TLTPQKRVIPLIPLM	nan	381	Q9N2J8
VPSMRPIILVGPSLK	CACNB1	226	Q02641
PPNNVSVPLLMPLVT	BCAR3	701	O75815
IMPTVVRPPKQLLPE	ATP13A3	586	Q9H7F0
TPMETISLPPPIIQP	AFF2	551	P51816
PASTPKRVPMGPIIV	GSE1	96	Q14687
IKPVLMSKSVPPSPE	ATXN7L1	241	Q9ULK2
VPPLKIPVSRISPMP	ASXL2	616	Q76L83
SPKVMQPLVQQPILP	RBM26	616	Q5T8P6
IQGLLVPSSPPMKKP	DCDC1	911	M0R2J8
SQSLPAMPVPIKPTP	FOXB2	356	Q5VYV0
DPQLPTVSPLPRVMI	MAP6	786	Q96JE9
TPSVIEPMKPLLLPQ	MGA	1176	Q8IWI9
IMAPTTIVTPVPLTP	MSS51	21	Q4VC12
QMVTVPPIAPGILKV	DOP1B	851	Q9Y3R5
PAPLVTPMVALVLPN	PER1	911	O15534
LPLPGVSTIPLTMKP	MUC3A	2881	Q02505
TPPPLPKKMIIRANT	PEAK1	1151	Q9H792
QLIAIKPTALPMVPP	KIAA1549L	1361	Q6ZVL6
QVPKLQPQITMIPPS	EIF4G2	486	P78344
LATQPKRPMSIPIIP	ITGB4	1316	P16144
LNTETPQITPPPVMI	POLA1	166	P09884
PKMPPPTILSTVPRQ	INO80E	206	Q8NBZ0
PSMIKIVPAHVPTPI	POM121B	596	A6NF01
TQVKTPVQVPLPHPM	FOXO1	556	Q12778
MPPPLPLLLLTVLVV	CPZ	1	Q66K79
IQPLGMVPLIPSPLS	E2F8	491	A0AVK6
MQTPVNIPVPVLRLP	GEMIN7	1	Q9H840
KPPQTLFPSIVKNMP	MAK	366	P20794
PLQVGVPPMTLPIIL	GBF1	1816	Q92538
VPPMTLPIILNPALI	GBF1	1821	Q92538
MLTVIEQPVPPTPAT	EMID1	156	Q96A84
RPTPSPLMKPLLVFV	DGKZ	286	Q13574
LPPLGSTIVMTKTPP	SBNO1	96	A3KN83
IPTEPTLMPPAKPTV	OTOGL	1431	Q3ZCN5
PEVPLAPTKPTAQLM	NYNRIN	586	Q9P2P1
LPPQPLMTLSLQSVP	FOXN4	346	Q96NZ1
KAVTPPMPLLTPATP	PUF60	301	Q9UHX1
PIVTQIRGLLLPPPM	EIF5B	896	O60841
TLLPAAPPLPMKVAI	NBEAL2	2676	Q6ZNJ1
KNIPMKPPTPLLNTT	PHLDB2	101	Q86SQ0
PLILPIPPLSTTPKM	NPAP1	436	Q9NZP6
PKPVVLTTVPMPSRA	ATF6B	246	Q99941
LSVPIEPPQIASPKM	C10orf90	271	Q96M02
VTLPSCPSLPMQPLI	USF3	496	Q68DE3
KPIQPKPTIMGEPIT	ZNF608	786	Q9ULD9
MLPPLKSGPTVPLID	ZZEF1	2096	O43149
VPLPTLKMQTTLVPP	TOX4	496	O94842
VTPIIDNPKIMKQPP	ULK4	421	Q96C45
KSSQMPRPSVPPLVK	NDC1	416	Q9BTX1