Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphorylase kinase activity	PHKA1 PHKA2	3.11e-05	4	46	2	GO:0004689
GeneOntologyMolecularFunction	enzyme regulator activity	STARD13 SERPINB5 NOD1 SGSM3 TNFRSF10D ARHGAP20 RGS12 ANXA3 NLRC4 EVI5L SFN OTUB1	6.33e-05	1418	46	12	GO:0030234
GeneOntologyMolecularFunction	enzyme activator activity	STARD13 NOD1 SGSM3 TNFRSF10D ARHGAP20 RGS12 NLRC4 EVI5L	1.12e-04	656	46	8	GO:0008047
GeneOntologyMolecularFunction	GTPase activator activity	STARD13 SGSM3 ARHGAP20 RGS12 EVI5L	4.41e-04	279	46	5	GO:0005096
GeneOntologyMolecularFunction	peptidase activator activity	NOD1 TNFRSF10D NLRC4	5.62e-04	70	46	3	GO:0016504
GeneOntologyMolecularFunction	GTPase binding	BICD2 SGSM3 RRAGD RRAGC EVI5L	1.38e-03	360	46	5	GO:0051020
GeneOntologyMolecularFunction	molecular function activator activity	STARD13 NOD1 SGSM3 TNFRSF10D ARHGAP20 BICRA RGS12 NLRC4 EVI5L	1.75e-03	1233	46	9	GO:0140677
GeneOntologyMolecularFunction	calcium/calmodulin-dependent protein kinase activity	PHKA1 PHKA2	1.76e-03	27	46	2	GO:0004683
GeneOntologyMolecularFunction	cysteine-type endopeptidase activator activity involved in apoptotic process	NOD1 TNFRSF10D	2.03e-03	29	46	2	GO:0008656
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP11 OTUB1 USP32	2.30e-03	114	46	3	GO:0004843
GeneOntologyMolecularFunction	peptidase activator activity involved in apoptotic process	NOD1 TNFRSF10D	2.46e-03	32	46	2	GO:0016505
GeneOntologyMolecularFunction	peptidase regulator activity	SERPINB5 NOD1 TNFRSF10D NLRC4	2.86e-03	257	46	4	GO:0061134
GeneOntologyMolecularFunction	deubiquitinase activity	USP11 OTUB1 USP32	2.92e-03	124	46	3	GO:0101005
GeneOntologyBiologicalProcess	positive regulation of TORC1 signaling	RRAGD RRAGC OTUB1 USP32	7.30e-06	56	46	4	GO:1904263
GeneOntologyBiologicalProcess	positive regulation of TOR signaling	RRAGD RRAGC OTUB1 USP32	2.74e-05	78	46	4	GO:0032008
GeneOntologyBiologicalProcess	regulation of TORC1 signaling	RRAGD RRAGC OTUB1 USP32	7.84e-05	102	46	4	GO:1903432
GeneOntologyBiologicalProcess	TORC1 signaling	RRAGD RRAGC OTUB1 USP32	1.01e-04	109	46	4	GO:0038202
GeneOntologyCellularComponent	Gtr1-Gtr2 GTPase complex	RRAGD RRAGC	2.71e-05	4	45	2	GO:1990131
GeneOntologyCellularComponent	phosphorylase kinase complex	PHKA1 PHKA2	4.51e-05	5	45	2	GO:0005964
Domain	Glyco_hydro_15	PHKA1 PHKA2	1.70e-05	3	45	2	PF00723
Domain	PHK_A/B_su	PHKA1 PHKA2	1.70e-05	3	45	2	IPR008734
Domain	Glyco_hydro_15/PHK	PHKA1 PHKA2	1.70e-05	3	45	2	IPR011613
Domain	NACHT	NOD1 NLRC4 NLRP5	2.24e-05	23	45	3	PS50837
Domain	NACHT_NTPase	NOD1 NLRC4 NLRP5	2.24e-05	23	45	3	IPR007111
Domain	Ub_USP-typ	USP11 USP32	3.40e-05	4	45	2	IPR028135
Domain	Gtr1_RagA	RRAGD RRAGC	3.40e-05	4	45	2	PF04670
Domain	Gtr1_RagA	RRAGD RRAGC	3.40e-05	4	45	2	IPR006762
Domain	Ubiquitin_3	USP11 USP32	3.40e-05	4	45	2	PF14836
Domain	Arfaptin	ARFIP1 ICA1	5.65e-05	5	45	2	PF06456
Domain	Arfaptin	ARFIP1 ICA1	5.65e-05	5	45	2	SM01015
Domain	AH_dom	ARFIP1 ICA1	5.65e-05	5	45	2	IPR010504
Domain	AH	ARFIP1 ICA1	5.65e-05	5	45	2	PS50870
Domain	DUSP	USP11 USP32	8.46e-05	6	45	2	SM00695
Domain	DUSP	USP11 USP32	8.46e-05	6	45	2	PF06337
Domain	-	USP11 USP32	1.18e-04	7	45	2	3.30.2230.10
Domain	Pept_C19_DUSP	USP11 USP32	1.18e-04	7	45	2	IPR006615
Domain	DUSP	USP11 USP32	1.18e-04	7	45	2	PS51283
Domain	6hp_glycosidase	PHKA1 PHKA2	1.57e-04	8	45	2	IPR012341
Domain	-	PHKA1 PHKA2	1.57e-04	8	45	2	1.50.10.10
Domain	TBC	SGSM3 TBC1D23 EVI5L	2.23e-04	49	45	3	SM00164
Domain	RabGAP-TBC	SGSM3 TBC1D23 EVI5L	2.81e-04	53	45	3	PF00566
Domain	TBC_RABGAP	SGSM3 TBC1D23 EVI5L	3.14e-04	55	45	3	PS50086
Domain	Rab-GTPase-TBC_dom	SGSM3 TBC1D23 EVI5L	3.14e-04	55	45	3	IPR000195
Domain	6-hairpin_glycosidase-like	PHKA1 PHKA2	4.35e-04	13	45	2	IPR008928
Domain	P-loop_NTPase	SHPRH NWD1 NOD1 SAMD9 RRAGD NLRC4 RRAGC NLRP5	8.45e-04	848	45	8	IPR027417
Domain	-	NOD1 NLRC4 NLRP5	1.46e-03	93	45	3	1.10.533.10
Domain	DEATH-like_dom	NOD1 NLRC4 NLRP5	1.74e-03	99	45	3	IPR011029
Domain	-	SHPRH NWD1 NOD1 SAMD9 RRAGD NLRC4 RRAGC	1.90e-03	746	45	7	3.40.50.300
Domain	CARD	NOD1 NLRC4	2.06e-03	28	45	2	PF00619
Domain	-	ARFIP1 ICA1	2.37e-03	30	45	2	1.20.1270.60
Domain	AH/BAR-dom	ARFIP1 ICA1	2.37e-03	30	45	2	IPR027267
Domain	CARD	NOD1 NLRC4	2.52e-03	31	45	2	IPR001315
Domain	CARD	NOD1 NLRC4	2.86e-03	33	45	2	PS50209
Domain	SAM_2	STARD13 SAMD9	4.81e-03	43	45	2	PF07647
Domain	-	LRIG3 NOD1 NLRC4 NLRP5	7.33e-03	321	45	4	3.80.10.10
Domain	LRR_6	NOD1 NLRP5	7.77e-03	55	45	2	PF13516
Domain	L_dom-like	LRIG3 NOD1 NLRC4 NLRP5	7.90e-03	328	45	4	IPR032675
Domain	RhoGAP	STARD13 ARHGAP20	9.79e-03	62	45	2	SM00324
Domain	RhoGAP	STARD13 ARHGAP20	1.01e-02	63	45	2	PF00620
Domain	RHOGAP	STARD13 ARHGAP20	1.04e-02	64	45	2	PS50238
Domain	RhoGAP_dom	STARD13 ARHGAP20	1.04e-02	64	45	2	IPR000198
Domain	-	STARD13 ARHGAP20	1.04e-02	64	45	2	1.10.555.10
Domain	USP_CS	USP11 USP32	1.10e-02	66	45	2	IPR018200
Domain	USP_1	USP11 USP32	1.24e-02	70	45	2	PS00972
Domain	UCH	USP11 USP32	1.27e-02	71	45	2	PF00443
Domain	USP_2	USP11 USP32	1.27e-02	71	45	2	PS00973
Domain	USP_3	USP11 USP32	1.30e-02	72	45	2	PS50235
Pathway	PID_P53_DOWNSTREAM_PATHWAY	SERPINB5 TNFRSF10D NLRC4 SFN	2.81e-04	137	33	4	M145
Pathway	REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS	PHKA1 PHKA2	4.75e-04	14	33	2	MM15391
Pathway	KEGG_MEDICUS_REFERENCE_FLCN_MTORC1_SIGNALING_PATHWAY	RRAGD RRAGC	4.75e-04	14	33	2	M47922
Pathway	KEGG_MEDICUS_REFERENCE_GATOR1_MTORC1_SIGNALING_PATHWAY	RRAGD RRAGC	4.75e-04	14	33	2	M47918
Pathway	REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS	PHKA1 PHKA2	4.75e-04	14	33	2	M19193
Pathway	PID_MTOR_4PATHWAY	RRAGD RRAGC SFN	5.51e-04	69	33	3	M121
Pathway	REACTOME_TP53_REGULATES_METABOLIC_GENES	RRAGD RRAGC SFN	6.50e-04	73	33	3	MM15223
Pathway	REACTOME_GLYCOGEN_METABOLISM	PHKA1 PHKA2	7.94e-04	18	33	2	MM15577
Pathway	REACTOME_TP53_REGULATES_METABOLIC_GENES	RRAGD RRAGC SFN	9.79e-04	84	33	3	M27495
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_TP53	TNFRSF10D RRAGD NLRC4 RRAGC SFN	1.39e-03	360	33	5	M27267
Pathway	REACTOME_MTORC1_MEDIATED_SIGNALLING	RRAGD RRAGC	1.42e-03	24	33	2	M3492
Pathway	WP_P53_TRANSCRIPTIONAL_GENE_NETWORK	SERPINB5 TNFRSF10D SFN	1.44e-03	96	33	3	M40062
Pathway	REACTOME_GLYCOGEN_METABOLISM	PHKA1 PHKA2	1.54e-03	25	33	2	M27857
Pathway	REACTOME_MTORC1_MEDIATED_SIGNALLING	RRAGD RRAGC	1.54e-03	25	33	2	MM14650
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	BICD2 PHKA1 PHKA2 KMT2D ARNT	1.14e-06	139	46	5	25476789
Pubmed	X-linked liver glycogenosis type II (XLG II) is caused by mutations in PHKA2, the gene encoding the liver alpha subunit of phosphorylase kinase.	PHKA1 PHKA2	1.71e-06	2	46	2	8733133
Pubmed	The multiphosphorylation domain of the phosphorylase kinase alpha M and alpha L subunits is a hotspot of differential mRNA processing and of molecular evolution.	PHKA1 PHKA2	1.71e-06	2	46	2	8226841
Pubmed	cDNA cloning of a liver isoform of the phosphorylase kinase alpha subunit and mapping of the gene to Xp22.2-p22.1, the region of human X-linked liver glycogenosis.	PHKA1 PHKA2	1.71e-06	2	46	2	1372435
Pubmed	The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.	RRAGD RRAGC	5.13e-06	3	46	2	24095279
Pubmed	Glucoamylase-like domains in the alpha- and beta-subunits of phosphorylase kinase.	PHKA1 PHKA2	5.13e-06	3	46	2	12876330
Pubmed	Cleavage of phosphorylase kinase and calcium-free calmodulin by HIV-1 protease.	PHKA1 PHKA2	1.03e-05	4	46	2	1872871
Pubmed	Isolation of cDNA clones for the catalytic gamma subunit of mouse muscle phosphorylase kinase: expression of mRNA in normal and mutant Phk mice.	PHKA1 PHKA2	1.03e-05	4	46	2	3472241
Pubmed	Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf.	NOD1 NLRC4	1.03e-05	4	46	2	16648853
Pubmed	Phosphorylase Kinase Deficiency	PHKA1 PHKA2	1.03e-05	4	46	2	21634085
Pubmed	Location of phosphorylase kinase (Phk) in the mouse X chromosome.	PHKA1 PHKA2	1.71e-05	5	46	2	4726088
Pubmed	SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.	RRAGD RRAGC	1.71e-05	5	46	2	22575674
Pubmed	A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.	RRAGD RRAGC	1.71e-05	5	46	2	32612235
Pubmed	Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.	RRAGD RRAGC	2.56e-05	6	46	2	24529380
Pubmed	A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D.	RRAGD RRAGC	2.56e-05	6	46	2	14660641
Pubmed	Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases.	RRAGD RRAGC	2.56e-05	6	46	2	24081491
Pubmed	Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.	NOD1 NLRC4	2.56e-05	6	46	2	16984919
Pubmed	The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.	RRAGD RRAGC	2.56e-05	6	46	2	18497260
Pubmed	Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches.	CD3E ARNT	2.56e-05	6	46	2	19286559
Pubmed	Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.	RRAGD RRAGC	2.56e-05	6	46	2	11073942
Pubmed	Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.	SGSM3 TBC1D23 EVI5L	2.57e-05	43	46	3	19077034
Pubmed	Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.	RRAGD RRAGC	3.58e-05	7	46	2	25259925
Pubmed	Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis.	NOD1 NLRC4	3.58e-05	7	46	2	17620097
Pubmed	The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production in Helicobacter pylori infected dendritic cells.	NOD1 NLRC4	3.58e-05	7	46	2	23818043
Pubmed	USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.	USP11 SFN	4.77e-05	8	46	2	22706160
Pubmed	Amino acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation.	RRAGD RRAGC	4.77e-05	8	46	2	26582740
Pubmed	Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling.	NOD1 NLRC4	6.12e-05	9	46	2	20348425
Pubmed	Plant Lectins Activate the NLRP3 Inflammasome To Promote Inflammatory Disorders.	NOD1 NLRC4	6.12e-05	9	46	2	28087670
Pubmed	Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.	NOD1 NLRC4	6.12e-05	9	46	2	15107016
Pubmed	Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.	RRAGD RRAGC	6.12e-05	9	46	2	24337580
Pubmed	Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.	RRAGD RRAGC	7.65e-05	10	46	2	22424946
Pubmed	Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation.	COQ8A MVP NLRP5	8.53e-05	64	46	3	34174788
Pubmed	Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.	NOD1 NLRC4	9.34e-05	11	46	2	17433728
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	ALAS1 RRAGD DSN1 RRAGC	1.08e-04	186	46	4	33637726
Pubmed	LncRNA DUXAP9-206 directly binds with Cbl-b to augment EGFR signaling and promotes non-small cell lung cancer progression.	SAMD9 SFN	1.12e-04	12	46	2	30515972
Pubmed	SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.	RRAGD RRAGC	1.12e-04	12	46	2	25561175
Pubmed	The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3.	SFN NLRP5	1.12e-04	12	46	2	39406751
Pubmed	Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.	RRAGD RRAGC	1.12e-04	12	46	2	20381137
Pubmed	Non-canonical inflammasome activation targets caspase-11.	NOD1 NLRC4	1.12e-04	12	46	2	22002608
Pubmed	AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.	NOD1 DSN1 RRAGC	1.21e-04	72	46	3	37398436
Pubmed	Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses.	CD3E TNFRSF10D	1.32e-04	13	46	2	25980612
Pubmed	Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection.	NOD1 NLRC4	1.32e-04	13	46	2	25704009
Pubmed	Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome.	PHKA1 PHKA2	1.54e-04	14	46	2	8432533
Pubmed	TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.	RRAGD RRAGC	1.54e-04	14	46	2	28716898
Pubmed	Comparative analysis of apoptosis and inflammation genes of mice and humans.	NOD1 TNFRSF10D NLRP5	1.66e-04	80	46	3	12819136
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	BICD2 PMPCB USP11 USP32	1.79e-04	212	46	4	33462405
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	SHPRH PHKA1 COQ8A RRAGC	1.79e-04	212	46	4	33853758
Pubmed	Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome.	NOD1 NLRC4	2.03e-04	16	46	2	23630357
Pubmed	Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.	ALAS1 SERPINB5 NOD1 SFN	2.49e-04	231	46	4	21048031
Pubmed	Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor.	ARHGAP20 NLRP5	2.88e-04	19	46	2	17567914
Pubmed	Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo.	TNFRSF10D SFN	4.25e-04	23	46	2	30858352
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	KMT2D BHLHE22	4.25e-04	23	46	2	9225980
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	LRIG3 CAAP1 SGSM3 TNFRSF10D ARFIP1 PMPCB BICRA	4.57e-04	1061	46	7	33845483
Pubmed	USP37 is a SNAI1 deubiquitinase.	USP11 OTUB1	4.64e-04	24	46	2	31911859
Pubmed	Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.	USP11 OTUB1	8.80e-04	33	46	2	30323974
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	STARD13 DSN1 ICA1 NLRP5	9.07e-04	326	46	4	17015433
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP11 OTUB1 USP32	9.83e-04	147	46	3	29576527
Pubmed	Blockade of TNF receptor superfamily 1 (TNFR1)-dependent and TNFR1-independent cell death is crucial for normal epidermal differentiation.	CD3E NLRC4	9.90e-04	35	46	2	29596938
Pubmed	Functional proteomics mapping of a human signaling pathway.	STARD13 PHKA2 KMT2D ARNT OTUB1	1.07e-03	591	46	5	15231748
Pubmed	Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).	ARFIP1 MVP	1.11e-03	37	46	2	16396496
GeneFamily	NLR family	NOD1 NLRC4 NLRP5	9.25e-06	25	30	3	666
GeneFamily	Classical BAR domain containing	ARFIP1 ICA1	7.41e-05	8	30	2	1292
GeneFamily	Ataxins\|Trinucleotide repeat containing	KMT2D BHLHE22	7.80e-04	25	30	2	775
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	NOD1 NLRC4	1.12e-03	30	30	2	959
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	STARD13 ARHGAP20	3.10e-03	50	30	2	721
GeneFamily	Ubiquitin specific peptidases	USP11 USP32	3.88e-03	56	30	2	366
GeneFamily	PHD finger proteins	SHPRH KMT2D	9.74e-03	90	30	2	88
GeneFamily	Basic helix-loop-helix proteins	ARNT BHLHE22	1.43e-02	110	30	2	420
Coexpression	LEI_MYB_TARGETS	BICD2 ALAS1 SERPINB5 ANXA3 SFN OTUB1	2.07e-05	323	46	6	M863
Coexpression	GSE30971_CTRL_VS_LPS_STIM_MACROPHAGE_WBP7_KO_4H_DN	PHKA2 PPARGC1B SERPINB5 TBC1D23 FILIP1L	2.37e-05	196	46	5	M8717
Coexpression	GSE37416_0H_VS_6H_F_TULARENSIS_LVS_NEUTROPHIL_UP	BICD2 PHKA2 MVP DSN1 USP32	2.49e-05	198	46	5	M5344
Coexpression	GSE22527_ANTI_CD3_INVIVO_VS_UNTREATED_MOUSE_TREG_DN	ARFIP1 DSN1 ICA1 RRAGC OTUB1	2.62e-05	200	46	5	M7709
Coexpression	DESCARTES_FETAL_LUNG_SQUAMOUS_EPITHELIAL_CELLS	SERPINB5 SAMD9 RRAGD RRAGC SFN	3.01e-05	206	46	5	M40237
ToppCell	droplet-Bladder-nan-3m-Epithelial-basal_bladder_epithelial_cell_(Krt5+Krt14+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BICD2 SERPINB5 COQ8A RGS12 ANXA3 SFN	4.83e-08	194	46	6	37803f4abf1aa1ad771c9cd293933003d7101e70
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BICD2 TEX14 RGS12 ANXA3 ICA1	1.60e-06	192	46	5	9a1aeac3ecf31f865a23d8ee15a82aef31779089
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BICD2 TEX14 RGS12 ANXA3 ICA1	1.60e-06	192	46	5	53d438e35c14e7656585942b788459e6d843c555
ToppCell	ileum-Epithelial_Stem_Cells\|ileum / shred on tissue and cell subclass	STARD13 TEX14 COQ8A ICA1	8.74e-06	126	46	4	a8ed48cbd1e207fd1aaad454fda9f329eb22aa83
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Keratinizing_Cervical_Squamous_Cell_Carcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	BICD2 SERPINB5 RRAGC SFN	2.46e-05	164	46	4	de1646dbcf2a10b48e021acf7dc63e803e6a47ce
ToppCell	356C-Lymphocytic-ILC-ILC-2\|ILC / Donor, Lineage, Cell class and subclass (all cells)	PPARGC1B URB1 NOD1 USP32	2.97e-05	172	46	4	4977e1f4deae781750e27a8054deccd336cfb74a
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PHKA2 URB1 NOD1 TTLL3	3.11e-05	174	46	4	a79ebb01a5849c314e02594a9c95009dbb03cb8c
ToppCell	PND14\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CD3E TEX14 RGS12 FILIP1L	3.86e-05	184	46	4	1bfee4eb121e76a79f48b06b45f05d124fbbedba
ToppCell	NS-critical-LOC-Epithelial-Basal\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SERPINB5 TNFRSF10D TEX14 SFN	4.03e-05	186	46	4	c28f62524637c7eb9c43c9ec38fb12dfec6f5566
ToppCell	facs-Lung-Endomucin-3m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEX14 RGS12 ANXA3 ICA1	4.03e-05	186	46	4	9d6cb36aa0aae69fe584dad31deafcfdcc9fd1db
ToppCell	droplet-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TEX14 RGS12 ANXA3 ICA1	4.20e-05	188	46	4	db0652f000d459493321b53239326706eace598c
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	BICD2 SERPINB5 SAMD9 SFN	4.29e-05	189	46	4	533c302df467d13ab639232daf4f8cafb808260b
ToppCell	droplet-Lung-nan-3m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEX14 RGS12 ANXA3 ICA1	4.29e-05	189	46	4	7b6cb745c0a637d6addc105a79059ed488fced39
ToppCell	facs-Skin\|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRIG3 SERPINB5 SFN FILIP1L	4.47e-05	191	46	4	ae524103331fa53fa82888dbb567fc36abcee7e0
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BICD2 TEX14 RGS12 ANXA3	4.56e-05	192	46	4	2360824910cd471c8286ca369ba144d90d984602
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BICD2 TEX14 RGS12 ANXA3	4.65e-05	193	46	4	ac1073bf4d3868841226b850b058f1e27326a14e
ToppCell	COVID_vent-Myeloid-Monocytic-Developing_Neutrophil\|COVID_vent / Disease condition, Lineage, Cell class and subclass	RRAGD ANXA3 NLRC4 ICA1	4.84e-05	195	46	4	de23409b1b4146b8ae286850b829ec8dceed0117
ToppCell	Basal-basal-10\|World / Class top	ALAS1 SERPINB5 ANXA3 SFN	5.24e-05	199	46	4	4fadfc58102b21bf9db9d0092f3437aa78fddd99
ToppCell	(0)_NK/T_cells-(0)_T_CD4\|(0)_NK/T_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	SERPINB5 RGS12 ICA1 SFN	5.24e-05	199	46	4	a4bffbb9587829f0f52716d6939315a1aa1ae9b3
ToppCell	proximal-Epithelial-Basal\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SERPINB5 RGS12 ANXA3 SFN	5.34e-05	200	46	4	c6a491d3e2dae6618f25dc3c9aac08f657348168
ToppCell	proximal-Epithelial-Basal-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SERPINB5 RGS12 ANXA3 SFN	5.34e-05	200	46	4	f5d48f521abbd1e07de05f2b3768ad2f9675f1e1
ToppCell	proximal-3-Epithelial-Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SERPINB5 RGS12 ANXA3 SFN	5.34e-05	200	46	4	8083047c213488e40b975013e3c5c43f7c0c15b2
Computational	Neighborhood of CDH3	SERPINB5 ANXA3 SFN	4.94e-05	27	29	3	GNF2_CDH3
Computational	Neighborhood of SERPINB5	SERPINB5 ANXA3 SFN	5.53e-05	28	29	3	GNF2_SERPINB5
Computational	Enzyme inhibitors (esp serine proteases).	SERPINB5 ANXA3 SFN	5.72e-04	61	29	3	MODULE_164
Drug	wortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT_HG-U133A	STARD13 PHKA2 ARNT COQ8A ICA1 FILIP1L	1.78e-06	183	46	6	1668_UP
Drug	Mesalamine [89-57-6]; Down 200; 26.2uM; HL60; HT_HG-U133A	BICD2 PHKA2 ARNT SAMD9 BICRA OTUB1	2.35e-06	192	46	6	6162_DN
Drug	Carteolol hydrochloride [51781-21-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A	URB1 ARNT SGSM3 DSN1 ANXA3 ICA1	2.81e-06	198	46	6	3276_UP
Drug	prochlorperazine dimaleate salt; Up 200; 10uM; HL60; HT_HG-U133A	STARD13 PHKA2 NOD1 SGSM3 ICA1	4.51e-05	195	46	5	1156_UP
Drug	Triamcinolone [124-94-7]; Down 200; 10.2uM; MCF7; HT_HG-U133A	PHKA2 URB1 RRAGD MVP RGS12	4.51e-05	195	46	5	2241_DN
Drug	quercetin dihydrate; Up 200; 1uM; MCF7; HG-U133A	BICD2 PHKA2 ARNT NOD1 ICA1	4.62e-05	196	46	5	283_UP
Drug	topiramate; Down 200; 3uM; MCF7; HT_HG-U133A_EA	PHKA2 ARNT SGSM3 SAMD9 BICRA	4.62e-05	196	46	5	915_DN
Drug	Nicardipine hydrochloride [54527-84-3]; Down 200; 7.8uM; MCF7; HT_HG-U133A	ARNT SAMD9 MVP RGS12 FILIP1L	4.74e-05	197	46	5	3215_DN
Drug	Chlorhexidine [55-56-1]; Down 200; 8uM; MCF7; HT_HG-U133A	PHKA2 ARNT RRAGD MVP SFN	4.85e-05	198	46	5	1525_DN
Drug	15d-PGJ2; Down 200; 10uM; MCF7; HG-U133A	PHKA1 NOD1 ARFIP1 ICA1 FILIP1L	4.85e-05	198	46	5	201_DN
Drug	Mephenytoin [50-12-4]; Up 200; 18.4uM; MCF7; HT_HG-U133A	ARNT NOD1 SGSM3 SAMD9 RGS12	4.97e-05	199	46	5	3580_UP
Drug	sulfonamide analog 1	PHKA1 PHKA2 ARNT NOD1 SFN	6.86e-05	213	46	5	CID005327336
Disease	Glycogen phosphorylase kinase deficiency	PHKA1 PHKA2	1.42e-05	4	46	2	cv:C0268147
Disease	follicular lymphoma (implicated_via_orthology)	RRAGD RRAGC	2.37e-05	5	46	2	DOID:0050873 (implicated_via_orthology)
Disease	glucose metabolism measurement, age-related hearing impairment	LRIG3 CAAP1 SAMD9	7.43e-05	52	46	3	EFO_0005782, EFO_0009367
Disease	glycogen storage disease (is_implicated_in)	PHKA1 PHKA2	8.50e-05	9	46	2	DOID:2747 (is_implicated_in)
Disease	visceral:subcutaneous adipose tissue ratio	BICD2 CAAP1 TBC1D23	1.80e-04	70	46	3	EFO_0004767
Disease	Lymphoma, Large-Cell, Follicular	KMT2D RRAGC	2.46e-04	15	46	2	C0079745
Disease	Lymphoma, Small Cleaved-Cell, Follicular	KMT2D RRAGC	2.46e-04	15	46	2	C0079765
Disease	Lymphoma, Mixed-Cell, Follicular	KMT2D RRAGC	2.46e-04	15	46	2	C0079758
Disease	Lymphoma, Follicular, Grade 2	KMT2D RRAGC	2.46e-04	15	46	2	C1956132
Disease	Lymphoma, Follicular, Grade 3	KMT2D RRAGC	2.46e-04	15	46	2	C1956131
Disease	Lymphoma, Follicular, Grade 1	KMT2D RRAGC	2.46e-04	15	46	2	C1956130
Disease	Glycogen storage disease	PHKA1 PHKA2	3.19e-04	17	46	2	cv:C0017919
Disease	Lymphoma, Follicular	KMT2D RRAGC	4.44e-04	20	46	2	C0024301
Disease	Keloid	SERPINB5 SFN	1.37e-03	35	46	2	C0022548
Disease	candidiasis (implicated_via_orthology)	RRAGD RRAGC	2.16e-03	44	46	2	DOID:1508 (implicated_via_orthology)
Disease	multiple sclerosis symptom measurement	CAAP1 USP32	2.36e-03	46	46	2	EFO_0803536
Disease	ocular hypertension, response to triamcinolone acetonide	TEX14 TTLL3	2.67e-03	49	46	2	EFO_0006954, EFO_1001069
Disease	idiopathic osteonecrosis of the femoral head	PPARGC1B SAMD9	3.00e-03	52	46	2	EFO_1001930

Protein segments in the cluster

Peptide	Gene	Start	Entry
DQELKHLILEAADGF	ARNT	161	P27540
LAFDGLSLARHLDED	EVI5L	716	Q96CN4
LHVSLDGLKFSDDAA	BICD2	276	Q8TD16
GLLDSHLIKEAGDAE	SFN	101	P31947
AAGEDDLFLHKSLSA	BHLHE22	11	Q8NFJ8
ADLSLKSLELHEEFG	ARFIP1	201	P53367
DSIKGELSGHFEDLL	ANXA3	226	P12429
EKELFLAEHSDLEEG	CAAP1	111	Q9H8G2
HGLSEAELKDVLSLD	NWD1	591	Q149M9
EKLHFSVDAESGDLL	PCDHGB6	71	Q9Y5F9
ELLDLAKFHFGDSLC	PMPCB	251	O75439
GDLDDLAQDLKDLYH	NLRC4	96	Q9NPP4
ELADLHGKDAALLFS	ALAS1	296	P13196
FTGLDALEHLDLSDN	LRIG3	406	Q6UXM1
KAALEALDELDLFGV	PHKA1	206	P46020
FTFDGLDELHSDLDL	NOD1	281	Q9Y239
HLKSLDLTDNALGDG	NLRP5	1066	P59047
LHLKALLDFEDKDGD	MVP	121	Q14764
FGFSHLEALLDDSKE	OTUB1	96	Q96FW1
GHQAEDLSRDDLLFL	FILIP1L	61	Q4L180
LSEELKHFADGLETD	DSN1	171	Q9H410
EDAHLDAILILGEAF	COQ8A	556	Q8NI60
GSDEDHLSLKEFSEL	CD3E	76	P07766
DLLNSALDIKEFFDH	KCNMB3	166	Q9NPA1
DFLHGSEKLDSDDLL	BICRA	21	Q9NZM4
NDDLADAGLEKIHLS	RRAGD	201	Q9NQL2
KAALEAIDELDLFGA	PHKA2	206	P46019
ASDADLDAKLELFHS	ICA1	51	Q05084
EGLLTLSDFDLAHSK	ARHGAP20	631	Q9P2F6
TGDLLDLEKDDLFPH	STARD13	471	Q9Y3M8
DDLADAGLEKLHLSF	RRAGC	201	Q9HB90
SKLLDAGGDLRLHDE	TEX14	106	Q8IWB6
ALLDLAEHASSAFKE	SAMD9	1151	Q5K651
KHFGLLETALEEEDL	PPARGC1B	766	Q86YN6
KALLDFERHDDDELG	SGSM3	486	Q96HU1
LLEAGLAKLDFLSDA	SHPRH	216	Q149N8
IKDLTDGHFENILAD	SERPINB5	136	P36952
LHFLLGLKTAADDDL	URB1	341	O60287
LLDASATLEEGHAKE	TNFRSF10D	346	Q9UBN6
IGLESHDDFALDASI	RGS12	211	O14924
HLFGSTLLGIKDDDA	TBC1D23	296	Q9NUY8
DLLKFDDLDGTHALM	TTLL3	91	Q9Y4R7
SQELLSFLLDGLHED	USP11	401	P51784
SQELLAFLLDGLHED	USP32	826	Q8NFA0
LDGLLFKDHDFSSDL	KLHL38	6	Q2WGJ6
KALEDDEELAHLGLG	KMT2D	3001	O14686