Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

NSD1 PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

2.95e-0855335GO:0042974
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

PRAMEF4 PRAMEF9 PRAMEF22 PRAMEF11 PRAMEF15

2.24e-0782335GO:1990756
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF4 PRAMEF9 PRAMEF22 PRAMEF11 PRAMEF15

4.68e-0795335GO:0140767
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

NSD1 PHF14 IGF2BP1 PRAMEF4 HMGA2 PRAMEF9 TCERG1L SKI PRAMEF22 PRAMEF11 PRAMEF15

1.43e-0611603311GO:0030674
GeneOntologyMolecularFunctionmolecular adaptor activity

NSD1 PHF14 IGF2BP1 PRAMEF4 HMGA2 PRAMEF9 TCERG1L SKI PRAMEF22 PRAMEF11 PRAMEF15

6.53e-0613563311GO:0060090
GeneOntologyMolecularFunctionnuclear receptor binding

NSD1 PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.31e-05187335GO:0016922
GeneOntologyMolecularFunctiontranscription factor binding

NSD1 PRAMEF4 HMGA2 SKI USP11 PRAMEF22 PRAMEF11 PRAMEF15

2.37e-05753338GO:0008134
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

NSD1 PRAMEF4 HMGA2 SKI PRAMEF22 PRAMEF11 PRAMEF15

3.81e-05582337GO:0140297
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

NSD1 PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 PRAMEF15

5.49e-05417336GO:0061629
GeneOntologyMolecularFunctionhistone H3K36 methyltransferase activity

NSD1 NSD3

2.04e-0413332GO:0046975
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

NSD1 NSD3

2.40e-0344332GO:0140938
GeneOntologyMolecularFunctionRNA polymerase binding

TCERG1L UVSSA

5.16e-0365332GO:0070063
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

NSD1 NSD3

5.64e-0368332GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

NSD1 NSD3

5.80e-0369332GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

NSD1 NSD3

6.13e-0371332GO:0042054
GeneOntologyMolecularFunctiontranscription corepressor activity

NSD1 HMGA2 SKI

6.30e-03229333GO:0003714
GeneOntologyBiologicalProcesssomatic stem cell population maintenance

PRAMEF4 HMGA2 SKI PRAMEF22 PRAMEF11 PRAMEF15

1.45e-08108326GO:0035019
GeneOntologyBiologicalProcessstem cell population maintenance

IGF2BP1 PRAMEF4 HMGA2 SKI PRAMEF22 PRAMEF11 PRAMEF15

6.38e-08237327GO:0019827
GeneOntologyBiologicalProcessmaintenance of cell number

IGF2BP1 PRAMEF4 HMGA2 SKI PRAMEF22 PRAMEF11 PRAMEF15

7.36e-08242327GO:0098727
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

NSD1 ZNF202 PHF14 PRAMEF4 HMGA2 PRAMEF9 SKI SGF29 PRAMEF22 PRAMEF11 NSD3 PRAMEF15

5.71e-0713993212GO:0045892
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

NSD1 ZNF202 PHF14 PRAMEF4 HMGA2 PRAMEF9 SKI SGF29 PRAMEF22 PRAMEF11 NSD3 PRAMEF15

6.35e-0714133212GO:1902679
GeneOntologyBiologicalProcessembryo development

PCDH15 NSD1 PLCG1 PRAMEF4 HMGA2 SKI SGF29 PRAMEF22 SPEG PRAMEF11 TTLL4 PRAMEF15

7.60e-0714373212GO:0009790
GeneOntologyBiologicalProcessblastocyst formation

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

6.28e-0678324GO:0001825
GeneOntologyBiologicalProcessblastocyst development

PRAMEF4 PRAMEF22 PRAMEF11 TTLL4 PRAMEF15

7.75e-06179325GO:0001824
GeneOntologyBiologicalProcessoocyte development

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.62e-0599324GO:0048599
GeneOntologyBiologicalProcessoocyte differentiation

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.89e-05103324GO:0009994
GeneOntologyBiologicalProcessfemale gamete generation

PRAMEF4 ALMS1 PRAMEF22 PRAMEF11 PRAMEF15

2.24e-05223325GO:0007292
GeneOntologyBiologicalProcessin utero embryonic development

PLCG1 PRAMEF4 PRAMEF22 SPEG PRAMEF11 TTLL4 PRAMEF15

2.91e-05596327GO:0001701
GeneOntologyBiologicalProcesschordate embryonic development

PLCG1 PRAMEF4 SKI PRAMEF22 SPEG PRAMEF11 TTLL4 PRAMEF15

5.52e-05906328GO:0043009
GeneOntologyBiologicalProcessembryo development ending in birth or egg hatching

PLCG1 PRAMEF4 SKI PRAMEF22 SPEG PRAMEF11 TTLL4 PRAMEF15

6.58e-05929328GO:0009792
GeneOntologyBiologicalProcessnegative regulation of developmental process

PHF14 PRAMEF4 HMGA2 PRAMEF9 ALMS1 SKI PRAMEF22 PRAMEF11 PRAMEF15

6.99e-051220329GO:0051093
GeneOntologyBiologicalProcessoogenesis

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

9.60e-05156324GO:0048477
GeneOntologyBiologicalProcessnegative regulation of cell differentiation

PRAMEF4 HMGA2 PRAMEF9 SKI PRAMEF22 PRAMEF11 PRAMEF15

3.20e-04875327GO:0045596
GeneOntologyBiologicalProcessregulation of DNA binding

NSD1 HMGA2 SKI

7.44e-04115323GO:0051101
GeneOntologyBiologicalProcessgerm cell development

PRAMEF4 ALMS1 PRAMEF22 PRAMEF11 PRAMEF15

8.16e-04482325GO:0007281
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF4 PRAMEF9 PRAMEF22 PRAMEF11 PRAMEF15

1.22e-0847345GO:0031462
GeneOntologyCellularComponentcilium

PCDH15 PDE4C PRAMEF4 ALMS1 EFCAB6 QRICH2 PRAMEF22 CEP164 PRAMEF11 TTLL4 PRAMEF15

9.98e-088983411GO:0005929
GeneOntologyCellularComponentcullin-RING ubiquitin ligase complex

CUL9 PRAMEF4 PRAMEF9 PRAMEF22 PRAMEF11 PRAMEF15

1.08e-06212346GO:0031461
GeneOntologyCellularComponentintracellular protein-containing complex

CUL9 IGF2BP1 PRAMEF4 PRAMEF9 SGF29 PRAMEF22 CEP164 PRAMEF11 PRAMEF15

1.79e-05972349GO:0140535
GeneOntologyCellularComponentubiquitin ligase complex

CUL9 PRAMEF4 PRAMEF9 PRAMEF22 PRAMEF11 PRAMEF15

1.97e-05352346GO:0000151
GeneOntologyCellularComponentmotile cilium

PRAMEF4 QRICH2 PRAMEF22 CEP164 PRAMEF11 PRAMEF15

2.07e-05355346GO:0031514
GeneOntologyCellularComponenttransferase complex

NSD1 CUL9 PRAMEF4 PRAMEF9 SGF29 PRAMEF22 PRAMEF11 PRAMEF15

1.23e-04963348GO:1990234
GeneOntologyCellularComponentacrosomal vesicle

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

3.37e-04206344GO:0001669
GeneOntologyCellularComponentchromatin

NSD1 PHF14 PRAMEF4 HMGA2 SGF29 PRAMEF22 PRAMEF11 NSD3 PRAMEF15

4.53e-041480349GO:0000785
MousePhenoabnormal jejunum morphology

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.06e-0641274MP:0004002
MousePhenoabnormal spermatogonia proliferation

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.86e-0647274MP:0002685
MousePhenoincreased circulating amylase level

PRAMEF4 ALMS1 PRAMEF22 PRAMEF11 PRAMEF15

2.86e-06119275MP:0008806
MousePhenoabnormal duodenum morphology

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

6.48e-0664274MP:0003271
MousePhenoincreased kidney weight

PRAMEF4 ALMS1 PRAMEF22 PRAMEF11 PRAMEF15

7.53e-06145275MP:0003917
MousePhenoabnormal circulating amylase level

PRAMEF4 ALMS1 PRAMEF22 PRAMEF11 PRAMEF15

1.07e-05156275MP:0008804
MousePhenoabnormal small intestine morphology

IGF2BP1 PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

2.58e-05187275MP:0000496
MousePhenoincreased male germ cell apoptosis

PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 PRAMEF15

2.72e-05189275MP:0014052
MousePhenoabnormal response to new environment

IGF2BP1 PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 TTLL4 NSD3 PRAMEF15

3.15e-05687278MP:0001413
MousePhenoabnormal cecum morphology

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

3.67e-0599274MP:0000494
MousePhenodecreased exploration in new environment

IGF2BP1 PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 NSD3 PRAMEF15

3.88e-05510277MP:0001417
MousePhenoabnormal kidney weight

PRAMEF4 ALMS1 PRAMEF22 PRAMEF11 PRAMEF15

4.30e-05208275MP:0002707
MousePhenoabnormal male accessory sex gland morphology

PRAMEF4 HMGA2 USP11 PRAMEF22 PRAMEF11 PRAMEF15

5.08e-05358276MP:0013330
MousePhenoabnormal pancreas morphology

CUL9 PRAMEF4 ALMS1 PRAMEF22 PRAMEF11 PRAMEF15

5.83e-05367276MP:0001944
MousePhenoenlarged urinary bladder

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

6.82e-05116274MP:0011874
MousePhenoabnormal male germ cell apoptosis

PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 PRAMEF15

7.83e-05236275MP:0008280
MousePhenoincreased fibroblast proliferation

PHF14 SKI USP11

8.07e-0544273MP:0011703
MousePhenoabnormal response to novelty

IGF2BP1 PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 TTLL4 NSD3 PRAMEF15

8.29e-05787278MP:0003107
MousePhenoazoospermia

PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 PRAMEF15

9.17e-05244275MP:0005159
MousePhenoabnormal male germ cell physiology

PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 PRAMEF15

9.17e-05244275MP:0020362
MousePhenoabnormal tail morphology

IGF2BP1 PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 PRAMEF15

9.79e-05403276MP:0002111
MousePhenoabsent gametes

PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 PRAMEF15

1.15e-04256275MP:0001117
MousePhenoabnormal germ cell physiology

PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 PRAMEF15

1.40e-04267275MP:0020363
MousePhenoabnormal large intestine morphology

IGF2BP1 PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.64e-04276275MP:0000489
MousePhenoabnormal exploration in a new environment

IGF2BP1 PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 NSD3 PRAMEF15

1.74e-04647277MP:0013189
MousePhenoabnormal seminal vesicle morphology

PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 PRAMEF15

3.20e-04319275MP:0002059
MousePhenoabnormal nonmotile primary cilium morphology

PCDH15 ALMS1 CEP164

3.23e-0470273MP:0013205
MousePhenoabnormal cell proliferation

PHF14 IGF2BP1 PRAMEF4 ALMS1 SKI USP11 PRAMEF22 PRAMEF11 PRAMEF15

4.88e-041294279MP:0000350
MousePhenoenlarged kidney

PRAMEF4 ALMS1 PRAMEF22 PRAMEF11 PRAMEF15

5.16e-04354275MP:0003068
MousePhenodecreased testis weight

PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 PRAMEF15

6.31e-04370275MP:0004852
MousePhenoabnormal auditory brainstem response

PCDH15 PRAMEF4 ALMS1 PRAMEF22 PRAMEF11 PRAMEF15

6.73e-04576276MP:0004738
MousePhenoabnormal hearing electrophysiology

PCDH15 PRAMEF4 ALMS1 PRAMEF22 PRAMEF11 PRAMEF15

7.91e-04594276MP:0006335
MousePhenoabnormal testis weight

PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 PRAMEF15

8.10e-04391275MP:0004850
MousePhenoabnormal exocrine gland morphology

IGF2BP1 PRAMEF4 HMGA2 USP11 PRAMEF22 PRAMEF11 PRAMEF15

9.29e-04853277MP:0013558
MousePhenoabnormal sperm number

PRAMEF4 HMGA2 QRICH2 PRAMEF22 PRAMEF11 PRAMEF15

1.02e-03624276MP:0002673
MousePhenodecreased male germ cell number

PRAMEF4 HMGA2 QRICH2 PRAMEF22 PRAMEF11 PRAMEF15

1.17e-03640276MP:0004901
MousePhenosmall kidney

IGF2BP1 PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.18e-03425275MP:0002989
MousePhenoabnormal hearing physiology

PCDH15 PRAMEF4 ALMS1 PRAMEF22 PRAMEF11 PRAMEF15

1.20e-03643276MP:0001963
MousePhenoabnormal urinary bladder morphology

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.21e-03247274MP:0000538
MousePhenoabnormal stomach morphology

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.23e-03248274MP:0000470
MousePhenoabnormal cilium morphology

PCDH15 HMGA2 ALMS1 QRICH2 CEP164

1.28e-03433275MP:0013202
MousePhenohearing/vestibular/ear phenotype

PCDH15 PRAMEF4 HMGA2 ALMS1 PRAMEF22 PRAMEF11 PRAMEF15

1.32e-03905277MP:0005377
MousePhenoabnormal primary cilium morphology

PCDH15 ALMS1 CEP164

1.34e-03114273MP:0013203
MousePhenoabnormal spermatogenesis

PRAMEF4 HMGA2 ALMS1 QRICH2 PRAMEF22 PRAMEF11 PRAMEF15

1.36e-03910277MP:0001156
MousePhenoabnormal ear physiology

PCDH15 PRAMEF4 ALMS1 PRAMEF22 PRAMEF11 PRAMEF15

1.64e-03684276MP:0003878
MousePhenodecreased germ cell number

PRAMEF4 HMGA2 QRICH2 PRAMEF22 PRAMEF11 PRAMEF15

1.68e-03687276MP:0002209
MousePhenoabnormal learning/memory/conditioning

IGF2BP1 PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 TTLL4 NSD3 PRAMEF15

1.79e-031239278MP:0002063
MousePhenodecreased epididymis weight

HMGA2 QRICH2

1.83e-0333272MP:0004929
MousePhenoabnormal cognition

IGF2BP1 PRAMEF4 HMGA2 PRAMEF22 PRAMEF11 TTLL4 NSD3 PRAMEF15

1.85e-031246278MP:0014114
MousePhenoabnormal kidney size

IGF2BP1 PRAMEF4 ALMS1 PRAMEF22 PRAMEF11 PRAMEF15

2.05e-03714276MP:0002706
MousePhenoabnormal epididymis weight

HMGA2 QRICH2

2.95e-0342272MP:0004927
MousePhenoabnormal gametes

PRAMEF4 HMGA2 QRICH2 PRAMEF22 PRAMEF11 PRAMEF15

3.30e-03785276MP:0001124
MousePhenoabnormal circulating enzyme level

CUL9 PHF14 PRAMEF4 ALMS1 PRAMEF22 PRAMEF11 NSD3 PRAMEF15

3.41e-031372278MP:0001570
MousePhenoabnormal gametogenesis

PRAMEF4 HMGA2 ALMS1 QRICH2 PRAMEF22 PRAMEF11 PRAMEF15

3.44e-031070277MP:0001929
DomainPRAME_family

PRAMEF4 PRAMEF22 PRAMEF15

4.35e-0619323IPR026271
DomainAWS

NSD1 NSD3

2.83e-055322PS51215
DomainAWS_dom

NSD1 NSD3

2.83e-055322IPR006560
DomainAWS

NSD1 NSD3

2.83e-055322SM00570
DomainZinc_finger_PHD-type_CS

NSD1 PHF14 NSD3

1.86e-0465323IPR019786
DomainPHD

NSD1 PHF14 NSD3

2.84e-0475323PF00628
DomainZnf_PHD-finger

NSD1 PHF14 NSD3

3.31e-0479323IPR019787
DomainPost-SET_dom

NSD1 NSD3

3.36e-0416322IPR003616
DomainPostSET

NSD1 NSD3

3.36e-0416322SM00508
DomainPOST_SET

NSD1 NSD3

3.36e-0416322PS50868
DomainRib_L2_dom2

CUL9 MRPL24

4.28e-0418322IPR014722
Domain-

CUL9 MRPL24

4.28e-04183222.30.30.30
DomainPHD

NSD1 PHF14 NSD3

4.69e-0489323SM00249
DomainZnf_PHD

NSD1 PHF14 NSD3

5.01e-0491323IPR001965
DomainPWWP

NSD1 NSD3

5.30e-0420322SM00293
DomainZF_PHD_2

NSD1 PHF14 NSD3

5.68e-0495323PS50016
DomainZF_PHD_1

NSD1 PHF14 NSD3

5.86e-0496323PS01359
DomainPWWP

NSD1 NSD3

7.04e-0423322PF00855
DomainPWWP_dom

NSD1 NSD3

7.04e-0423322IPR000313
DomainPWWP

NSD1 NSD3

7.67e-0424322PS50812
DomainZnf_FYVE_PHD

NSD1 PHF14 NSD3

2.00e-03147323IPR011011
DomainSET

NSD1 NSD3

2.24e-0341322PF00856
DomainSET

NSD1 NSD3

2.81e-0346322SM00317
DomainWW

TCERG1L CEP164

3.05e-0348322SM00456
DomainEF_Hand_1_Ca_BS

PLCG1 EFCAB6 FSTL5

3.28e-03175323IPR018247
DomainSET_dom

NSD1 NSD3

3.31e-0350322IPR001214
DomainSET

NSD1 NSD3

3.31e-0350322PS50280
DomainWW_DOMAIN_2

TCERG1L CEP164

3.44e-0351322PS50020
DomainWW_DOMAIN_1

TCERG1L CEP164

3.44e-0351322PS01159
DomainWW_dom

TCERG1L CEP164

3.57e-0352322IPR001202
DomainEF_HAND_1

PLCG1 EFCAB6 FSTL5

5.04e-03204323PS00018
DomainEF_HAND_2

PLCG1 EFCAB6 FSTL5

7.11e-03231323PS50222
DomainEF_hand_dom

PLCG1 EFCAB6 FSTL5

7.20e-03232323IPR002048
Domain-

PLCG1 EFCAB6 FSTL5

9.92e-032613231.10.238.10
DomainEF-hand-dom_pair

PLCG1 EFCAB6 FSTL5

1.28e-02287323IPR011992
DomainRING

NSD1 CUL9 NSD3

1.51e-02305323SM00184
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

NSD1 PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

2.43e-103535519389355
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

2.03e-091735423565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

2.03e-091735437781892
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

2.60e-091835429731491
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

2.60e-091835423894331
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

2.60e-091835414675769
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

2.60e-091835412890732
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

2.60e-091835439181896
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

3.29e-091935428604677
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

4.11e-092035416580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

4.11e-092035421425410
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

4.11e-092035426694250
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

6.20e-092235431729367
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

7.50e-092335419480014
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.07e-082535437451217
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.07e-082535412620990
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.26e-082635418500982
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.73e-082835425089626
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

2.31e-083035438786026
Pubmed

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

3.03e-083235437889087
Pubmed

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.36e-074635417287250
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.91e-075035431806660
Pubmed

ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

3.51e-075835431598710
Pubmed

An abundance of X-linked genes expressed in spermatogonia.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

3.76e-075935411279525
Pubmed

Cep164, a novel centriole appendage protein required for primary cilium formation.

ALMS1 CEP164

9.84e-07235217954613
Pubmed

The NSD family of protein methyltransferases in human cancer.

NSD1 NSD3

2.95e-06335225942451
Pubmed

The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors.

NSD1 NSD3

2.95e-06335235532818
Pubmed

miR-222 represses expression of zipcode binding protein-1 and phospholipase C-γ1 in intestinal epithelial cells.

IGF2BP1 PLCG1

2.95e-06335230649922
Pubmed

Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2.

IGF2BP1 HMGA2

5.90e-06435215225648
Pubmed

Histone and DNA binding ability studies of the NSD subfamily of PWWP domains.

NSD1 NSD3

5.90e-06435234271259
Pubmed

Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.

NSD1 NSD3

9.82e-06535239390582
Pubmed

In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.

NSD1 NSD3

9.82e-06535225494638
Pubmed

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

PRAMEF4 ALMS1 PRAMEF22 PRAMEF11 PRAMEF15

1.81e-0532635517015433
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

IGF2BP1 PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

2.44e-0534735516033648
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

FAHD2A PRAMEF4 USP11 PRAMEF22 CRACDL PRAMEF11 TTLL4 PRAMEF15

2.58e-05124235830973865
Pubmed

Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.

IGF2BP1 HMGA2

3.53e-05935220195514
Pubmed

Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts.

IGF2BP1 HMGA2

5.38e-051135223630078
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

NSD1 PLCG1 PRAMEF4 PRAMEF22 PRAMEF11 TTLL4 PRAMEF15

8.78e-05108435711544199
Pubmed

A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.

NSD1 NSD3

8.89e-051435226912663
Pubmed

Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea.

HMGA2 SKI

1.33e-041735230786278
Pubmed

Maternal microRNAs are essential for mouse zygotic development.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.61e-0427335417369397
Pubmed

Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.

IGF2BP1 HMGA2

1.85e-042035223704328
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

CUL9 HMGA2 SKI SGF29 MRPL24 USP11

1.94e-0485735625609649
Pubmed

Proteomic characterization of the human centrosome by protein correlation profiling.

ALMS1 CEP164

3.15e-042635214654843
Pubmed

The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea.

IGF2BP1 HMGA2

3.15e-042635226139524
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

4.73e-0436335414691545
Pubmed

Human transcription factor protein interaction networks.

CUL9 IGF2BP1 ALMS1 SKI SGF29 MRPL24 USP11

4.77e-04142935735140242
Pubmed

A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties.

IGF2BP1 HMGA2

4.79e-043235224192035
Pubmed

Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.

PCDH15 FSTL5

5.09e-043335220966902
Pubmed

The DNA sequence and biological annotation of human chromosome 1.

PRAMEF4 PRAMEF9 SKI MRPL24 PRAMEF22 PRAMEF11

5.20e-04103135616710414
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

ANKRD33 PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

5.40e-0467435537196079
Pubmed

Effects of glucokinase haploinsufficiency on the pancreatic β-cell mass and function of long-term high-fat, high-sucrose diet-fed mice.

PCDH15 ANKRD34C

6.41e-043735239305123
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NSD1 CUL9 PLCG1 SPEG TTLL4 NSD3

7.48e-04110535635748872
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

CUL9 ALMS1 SKI SGF29 USP11 NSD3

7.88e-04111635631753913
Pubmed

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

8.46e-0442435421731673
InteractionPRAMEF4 interactions

PRAMEF4 PRAMEF9

8.28e-063342int:PRAMEF4
Cytoband1p36.21

PRAMEF4 PRAMEF9 PRAMEF22 PRAMEF11 PRAMEF15

1.30e-09633551p36.21
CytobandEnsembl 112 genes in cytogenetic band chr1p36

PRAMEF4 PRAMEF9 SKI PRAMEF11 PRAMEF15

1.59e-04681355chr1p36
Cytoband2q11.2

FAHD2A CRACDL

1.40e-03723522q11.2
Cytoband11q23.3

ZNF202 CEP164

1.64e-037835211q23.3
CytobandEnsembl 112 genes in cytogenetic band chr2q35

SPEG TTLL4

4.39e-03129352chr2q35
CytobandEnsembl 112 genes in cytogenetic band chr2q11

FAHD2A CRACDL

6.11e-03153352chr2q11
GeneFamilyPRAME family

PRAMEF4 PRAMEF9 PRAMEF22 PRAMEF11 PRAMEF15

1.71e-1024265686
GeneFamilyPHD finger proteins

NSD1 PHF14 NSD3

2.85e-049026388
GeneFamilyPWWP domain containing

NSD1 NSD3

4.51e-04222621147
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

NSD1 NSD3

1.08e-0334262487
GeneFamilyEF-hand domain containing

PLCG1 EFCAB6 FSTL5

3.71e-03219263863
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

SPEG FSTL5

2.23e-02161262593
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED

PRAMEF4 PRAMEF22 SPEG PRAMEF11 PRAMEF15

1.08e-0857345MM1262
CoexpressionMIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED

NSD1 PRAMEF4 PRAMEF22 SPEG FSTL5 PRAMEF11 PRAMEF15

3.83e-08261347MM1277
CoexpressionKINNEY_DNMT1_METHYLATION_TARGETS

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

1.06e-0734344MM955
CoexpressionSANSOM_APC_TARGETS

PRAMEF4 HMGA2 SGF29 PRAMEF22 PRAMEF11 PRAMEF15

6.78e-07245346MM735
CoexpressionBYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS

NSD1 PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

3.42e-06180345MM612
CoexpressionKOHOUTEK_CCNT2_TARGETS

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

3.66e-0681344MM938
CoexpressionMORI_SMALL_PRE_BII_LYMPHOCYTE_UP

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

7.82e-0698344MM592
CoexpressionDESCARTES_ORGANOGENESIS_SCHWANN_CELL_PRECURSOR

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

7.82e-0698344MM3656
CoexpressionHUANG_GATA2_TARGETS_DN

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

7.82e-0698344MM942
CoexpressionYAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN

PRAMEF4 PRAMEF22 SPEG PRAMEF11 PRAMEF15

4.63e-05309345MM1244
CoexpressionINGRAM_SHH_TARGETS_UP

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

4.87e-05156344MM550
CoexpressionMEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED

CUL9 PRAMEF4 PRAMEF22 SPEG PRAMEF11 PRAMEF15

8.58e-05574346MM820
CoexpressionBOYERINAS_ONCOFETAL_TARGETS_OF_LET7A1

IGF2BP1 HMGA2

1.07e-0412342M9626
CoexpressionYAMAZAKI_TCEB3_TARGETS_DN

PRAMEF4 PRAMEF22 PRAMEF11 PRAMEF15

2.25e-04232344MM1019
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Monophasic_Synovial_Sarcoma-5|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

PRAMEF4 PRAMEF9 PRAMEF11 PRAMEF15

8.53e-07933543e05ea0f8f4a7cdb78a596f47d563dc3c94d4d8e
ToppCellBrain_organoid-organoid_Kanton_Nature|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.

PHF14 IGF2BP1 USP11 NSD3

1.31e-05185354857c7ca8493e91ef1d0078ddafd6082020f9b169
DrugTiratricol, 3,3',5-triiodothyroacetic acid [51-24-1]; Up 200; 6.4uM; HL60; HG-U133A

PLCG1 HMGA2 SGF29 TTLL4 NSD3

1.07e-051983451412_UP
DrugIopamidol [60166-93-0]; Down 200; 5.2uM; PC3; HT_HG-U133A

ZNF202 CUL9 SGF29 SPEG NSD3

1.10e-051993455832_DN
DiseaseSotos syndrome 1 (implicated_via_orthology)

NSD1 NSD3

3.00e-063302DOID:0112103 (implicated_via_orthology)
Diseaseinsomnia measurement

PCDH15 PHF14 IGF2BP1 HMGA2 ALMS1

7.80e-05443305EFO_0007876
Diseaseinfant head circumference

PLCG1 HMGA2

1.04e-0415302EFO_0004577
Diseasesyndrome (implicated_via_orthology)

NSD1 NSD3

1.51e-0418302DOID:225 (implicated_via_orthology)
Diseasenumber of teeth measurement

IGF2BP1 HMGA2

1.88e-0420302EFO_0010073
Diseaseodontogenesis

IGF2BP1 HMGA2

2.72e-0424302GO_0042476
Diseasetooth eruption

IGF2BP1 HMGA2

3.72e-0428302GO_0044691
Diseaseurate measurement

NSD1 PDE4C ANKRD33 SKI QRICH2

1.93e-03895305EFO_0004531
Diseasenicotine dependence symptom count, depressive symptom measurement

PCDH15 FSTL5

2.65e-0375302EFO_0007006, EFO_0009262
Diseaseshort-term memory

PCDH15 FSTL5

3.23e-0383302EFO_0004335
Diseaseuric acid measurement

ANKRD33 SKI QRICH2 NSD3

3.23e-03610304EFO_0004761
Diseasesmoking cessation

PCDH15 HMGA2 ALMS1

4.31e-03325303EFO_0004319
Diseasediastolic blood pressure, systolic blood pressure

HMGA2 ALMS1 CEP164 SPEG

4.52e-03670304EFO_0006335, EFO_0006336

Protein segments in the cluster

PeptideGeneStartEntry
RARLPQLKRLQSEPW

ANKRD34C

241

P0C6C1
ITKTRPWREPLREQN

ALMS1

3991

Q8TCU4
PKKRWQRLNQRRTKP

NSD1

1156

Q96L73
WRIRQLLRRPQVEQL

ANKRD33

241

Q7Z3H0
DRWKSLRQQLRERPP

QRICH2

1391

Q9H0J4
RKIQIRNIPPQLRWE

IGF2BP1

81

Q9NZI8
QRIQISLWPRKQKRR

FAM157A

91

C9JC47
HLWRQPRRPIRIQQR

PDE4C

31

Q08493
LTQGVRPRRWKLQVL

PRAMEF15

91

P0DUQ1
RRRLLTVLLQAQKWP

FAHD2A

6

Q96GK7
QVSEPKKWNLRRNRP

PHF14

176

O94880
QPAPPWITVTRQKRR

CRACDL

821

Q6NV74
LRPPIIWKRNNIILN

FSTL5

276

Q8N475
RKVPNRPEIIDLQQW

PCDH15

1586

Q96QU1
WRTDEAPQRLIRPKQ

EFCAB6

811

Q5THR3
PRGRPRKWPQQVVQK

HMGA2

76

P52926
NLNRFWPIIQIRIKR

CUL9

1266

Q8IWT3
RRQLQKQERPEWQDP

UVSSA

611

Q2YD98
RPRWARPLKRLQQEE

NTN5

456

Q8WTR8
LAQKVRPRRWKLQVL

PRAMEF22

91

A3QJZ6
DKRKNPPWIRRRPVV

MRPL24

31

Q96A35
VVKELQEQLWPRARP

SKI

701

P12755
NRRWLERVKNDPRLP

CEP164

1416

Q9UPV0
QQQPRRRQPLLWPMD

TCERG1L

16

Q5VWI1
LNLGVRPRRWKLQVL

PRAMEF4

91

O60810
PKPVVSWLRNRQPVR

SPEG

896

Q15772
SRRRVIPLPQWKANP

SGF29

206

Q96ES7
LTQGVRPRRWKLQVL

PRAMEF9

91

P0DUQ2
DPRRWVQKPPLNIQR

TROAP

46

Q12815
QAPTPLQIERWLRKQ

PLCG1

146

P19174
LTQGVRPRRWKLQVL

PRAMEF11

91

O60813
IRKPRPQRERAQWDI

NSD3

356

Q9BZ95
KWSQLPKRRPLLVQR

TTLL4

736

Q14679
VEGLQKQPRRPRRWV

ZNF202

121

O95125
QWPPRRRRKQLFTLQ

USP11

706

P51784