Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain5HT_rcpt

HTR1A HTR2B

1.22e-049352IPR002231
DomainPH

DOCK10 GRB10 PLCG2

8.92e-03229353PF00169
DomainPH

DOCK10 GRB10 PLCG2

1.50e-02278353SM00233
DomainPH_DOMAIN

DOCK10 GRB10 PLCG2

1.52e-02279353PS50003
DomainPH_domain

DOCK10 GRB10 PLCG2

1.53e-02280353IPR001849
DomainSH2

GRB10 PLCG2

1.53e-02101352PF00017
DomainSH2

GRB10 PLCG2

1.80e-02110352SM00252
DomainSH2

GRB10 PLCG2

1.83e-02111352PS50001
Pubmed

Overexpression of CDC14B causes mitotic arrest and inhibits zygotic genome activation in mouse preimplantation embryos.

CDC14C CDC14B

1.10e-06237219923902
Pubmed

The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway.

CDC14C CDC14B

1.10e-06237221502810
Pubmed

Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein.

CDC14C CDC14B

1.10e-06237218547142
Pubmed

Early-onset aging and defective DNA damage response in Cdc14b-deficient mice.

CDC14C CDC14B

3.30e-06337221262768
Pubmed

5-Hydroxytryptamine 1A and 2B serotonin receptors in neurite outgrowth: involvement of early growth response protein 1.

HTR1A HTR2B

3.30e-06337224158140
Pubmed

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.

CDC14C CDC14B

3.30e-06337222355704
Pubmed

CDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of mouse oocytes.

CDC14C CDC14B

3.30e-06337219129509
Pubmed

Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.

CDC14C CDC14B

3.30e-06337226283732
Pubmed

CDC14A phosphatase is essential for hearing and male fertility in mouse and human.

CDC14C CDC14B

6.60e-06437229293958
Pubmed

Expression of serotonin receptors 5-HT1A, 5-HT1B, 5-HT2B and 5-HT4 in ovary and in ovarian tumours.

HTR1A HTR2B

6.60e-06437222493371
Pubmed

Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/CCdh1 regulation during meiotic G2/M transition in mouse oocytes.

CDC14C CDC14B

6.60e-06437232341029
Pubmed

An autoradiographic study of serotonergic receptors in a murine genetic model of anxiety-related behaviors.

HTR1A HTR2B

1.10e-0553728833759
Pubmed

Involvement of neurotransmitters in the action of growth hormone-releasing hormone antagonist on passive avoidance learning.

HTR1A HTR2B

8.53e-051337222640814
Pubmed

Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice.

HTR1A HTR2B

8.53e-051337222569571
Pubmed

Genetic evaluation of the serotonergic system in chronic fatigue syndrome.

HTR1A HTR2B

8.53e-051337218079067
Pubmed

Association study of the serotoninergic system in migraine in the Spanish population.

HTR1A HTR2B

1.67e-041837219455600
Pubmed

Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis.

STRA8 DNTTIP1

1.67e-041837234075040
Pubmed

Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder.

HTR1A HTR2B

1.86e-041937219095219
Pubmed

Npat-dependent programmed Sertoli cell proliferation is indispensable for testis cord development and germ cell mitotic arrest.

CASP8AP2 STRA8

1.86e-041937231084574
Pubmed

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

HTR1A PLCG2 HTR2B NRG3

2.86e-0430037419086053
Pubmed

A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure.

HTR1A HTR2B

4.09e-042837219737523
Pubmed

Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.

POGLUT3 MAN2A1

4.39e-042937212652657
Pubmed

CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.

GRB10 CMKLR1 IL18R1

5.07e-0414637329688375
Pubmed

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors.

DIAPH2 NPEPPS DNTTIP1 DYRK2

5.63e-0435937435559673
Pubmed

Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.

HTR1A NRG3

5.69e-043337224204828
Pubmed

Genome-scale RNAi screen for host factors required for HIV replication.

DCBLD1 ETV3 CMKLR1 IL18R1

5.75e-0436137418976975
Pubmed

Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.

PPARA ALPK1

6.05e-043437215221005
Pubmed

5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival.

HTR1A HTR2B

6.41e-043537228031476
Pubmed

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.

PRPF31 PPIL2 POGLUT3 NPEPPS

6.83e-0437837434315543
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

ETV3 GRB10 PRPF31 ALPK1 HIF1AN DNTTIP1

7.34e-04103837626673895
Pubmed

Genetic loci associated with circulating levels of very long-chain saturated fatty acids.

PPARA NPEPPS

9.23e-044237225378659
Pubmed

Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration.

PLCG2 NRG3

9.67e-044337236878279
Pubmed

BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing.

DIAPH2 STRA8

1.01e-034437238085152
Pubmed

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.

PRPF31 TIMM44 BZW2 NPEPPS

1.03e-0342237427342126
CytobandEnsembl 112 genes in cytogenetic band chr7p12

CDC14C GRB10

1.20e-0363372chr7p12
CytobandEnsembl 112 genes in cytogenetic band chr6q22

DCBLD1 CLVS2

4.75e-03127372chr6q22
GeneFamily5-hydroxytryptamine receptors, G protein-coupled

HTR1A HTR2B

9.00e-0513202170
GeneFamilySH2 domain containing

GRB10 PLCG2

5.50e-03101202741
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

DOCK10 GRB10

2.15e-02206202682
ToppCellTCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell-4|TCGA-Uvea / Sample_Type by Project: Shred V9

MAN2A1 HTR2B C12orf60 DYRK2

1.61e-051843749c56753e5e668be888662e4713cf4ce44e6c58fb
ToppCellCOVID-19-kidney-Glomerular_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

GRB10 PLCG2 NRG3 IL18R1

1.98e-05194374660535b492445063d965095a50e1e299ce04c50a
ToppCellIPF-Endothelial-VE_Venous|Endothelial / Disease state, Lineage and Cell class

HTR2B NRG3 C12orf60 IL18R1

1.98e-05194374e8a9005963704286bcc50785bda8d7d63ec001b1
ToppCellLPS_only-Hematopoietic_Myeloid-Dendritic_cells-pDC|LPS_only / Treatment groups by lineage, cell group, cell type

DOCK10 ETV3 SLC24A4 IL18R1

2.14e-05198374d205dfcfe1f20e1e21bf84759e723d9e6e610a5c
Drugstaurosporine; Down 200; 0.01uM; SKMEL5; HG-U133A

DOCK10 PRPF31 PPIL2 ALPK1 TIMM44 DYRK2

7.02e-07196376508_DN
DrugPhotofrin

HGD HTR1A HTR2B

5.15e-0621373CID000057166
Drugamperozide

DIAPH2 HTR1A HTR2B

2.49e-0535373CID000073333
Drugbutyranilide

HTR1A HTR2B

2.56e-055372CID000014323
DrugATC0175

HTR1A HTR2B

2.56e-055372CID009934032
DrugMethysergide

HTR1A HTR2B

2.56e-055372DB00247
DrugOrg 6997

HTR1A HTR2B

2.56e-055372CID000171831
DrugSB221284

HTR1A HTR2B

2.56e-055372CID000443389
DrugDmipap

HTR1A HTR2B

3.84e-056372CID000126620
DrugBrAcTFMPP

HTR1A HTR2B

3.84e-056372CID000146887
Drugcompound 31

HTR1A PPARA HTR2B

4.34e-0542373CID005288687
Drugondansetron

HTR1A ALPK1 HTR2B

5.00e-0544373CID000004595
DrugKytril

HTR1A ALPK1 HTR2B

5.35e-0545373CID000003510
DrugEletriptan

HTR1A HTR2B

5.37e-057372DB00216
Drug1192U90

HTR1A HTR2B

5.37e-057372CID000127912
DrugSC 53116

HTR1A HTR2B

5.37e-057372CID000132337
DrugAC 695

HTR1A PLCG2 HTR2B

6.10e-0547373CID000004885
Drugchloroamphetamine

HTR1A HTR2B

7.15e-058372CID000541822
DrugBW501

HTR1A HTR2B

7.15e-058372CID000172195
DrugSB215,505

HTR1A HTR2B

7.15e-058372CID006603999
DrugAC1L2ZOK

HTR1A HTR2B

7.15e-058372CID000131724
Drugmedifoxamine

HTR1A HTR2B

7.15e-058372CID000036109
DrugSB 216641

HTR1A HTR2B

7.15e-058372CID003292447
Drugamesergide

HTR1A HTR2B

7.15e-058372CID000060740
DrugRo 04-6790

HTR1A HTR2B

9.18e-059372CID005312145
DrugCHEBI:334542

HTR1A HTR2B

9.18e-059372CID010884046
DrugCHEBI:334375

HTR1A HTR2B

9.18e-059372CID010476504
Drugseganserin

HTR1A HTR2B

1.15e-0410372CID000071767
DrugLY344864

HTR1A HTR2B

1.15e-0410372CID005311097
DrugRS-127445

HTR1A HTR2B

1.40e-0411372CID000196968
Drughomophthalimide

HTR1A HTR2B

1.40e-0411372CID000349435
DrugBRL15572

HTR1A HTR2B

1.68e-0412372CID003654103
DrugS 14506

HTR1A HTR2B

1.68e-0412372CID000131905
DrugLSD tartrate

HTR1A HTR2B

1.68e-0412372CID000159828
Drugsergolexole

HTR1A HTR2B

1.68e-0412372CID000060262
Drugocaperidone

HTR1A HTR2B

1.68e-0412372CID000071351
Drug6-MBOA

DIAPH2 ALPK1

1.98e-0413372CID000010772
Drugcianopramine

HTR1A HTR2B

1.98e-0413372CID000048126
DrugAC1O5P4A

HTR1A HTR2B

1.98e-0413372CID005464200
DrugMDL 73005EF

HTR1A HTR2B

1.98e-0413372CID000060769
Drug2,5-dimethoxy-4-methylamphetamine

HTR1A HTR2B

1.98e-0413372CID000085874
DrugLisuride

HTR1A HTR2B

2.31e-0414372DB00589
Drugxylamidine

HTR1A HTR2B

2.31e-0414372CID000022950
DrugPramipexole

HTR1A HTR2B

2.31e-0414372DB00413
Drugcompound 4d

HTR1A HTR2B

2.31e-0414372CID000448577
DrugRopinirole

HTR1A HTR2B

2.31e-0414372DB00268
DrugL-694,247

HTR1A HTR2B

2.31e-0414372CID000132059
DrugYM348

HTR1A HTR2B

2.31e-0414372CID003045225
DrugMcN5652

HTR1A HTR2B

2.31e-0414372CID000146919
DrugCabergoline

HTR1A HTR2B

2.66e-0415372DB00248
Drugdotarizine

HTR1A HTR2B

2.66e-0415372CID000055285
Drugaltanserin

HTR1A HTR2B

2.66e-0415372CID003033676
DrugApomorphine

HTR1A HTR2B

2.66e-0415372DB00714
DrugGuaifenesin [93-14-1]; Down 200; 20.2uM; MCF7; HT_HG-U133A

DIAPH2 GRB10 PPIL2 DYRK2

2.71e-041943743431_DN
DrugTolazoline hydrochloride [59-97-2]; Down 200; 20.4uM; HL60; HG-U133A

PRPF31 PPIL2 TIMM44 HIF1AN

2.76e-041953742000_DN
DrugFamprofazone [22881-35-2]; Down 200; 10.6uM; MCF7; HT_HG-U133A

PPIL2 PLCG2 ALPK1 CDC14B

2.82e-041963746029_DN
DrugFlunarizine dihydrochloride [30484-77-6]; Up 200; 8.4uM; HL60; HT_HG-U133A

PPIL2 PPARA HTR2B CDC14B

2.82e-041963742381_UP
Drugaspirin, USP; Up 200; 100uM; MCF7; HT_HG-U133A_EA

DIAPH2 GRB10 ALPK1 CDC14B

2.87e-041973741042_UP
DrugMethacholine chloride [62-51-1]; Up 200; 20.4uM; PC3; HT_HG-U133A

DIAPH2 PPIL2 PLCG2 ALPK1

2.87e-041973745773_UP
DrugDAPH; Down 200; 10uM; MCF7; HG-U133A

PPIL2 MAN2A1 HIF1AN DYRK2

2.87e-04197374624_DN
DrugCefamandole sodium salt [30034-03-8]; Down 200; 8.2uM; MCF7; HT_HG-U133A

DIAPH2 GRB10 CDC14B HIF1AN

2.87e-041973743436_DN
Drug17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A

GRB10 PPIL2 TIMM44 HIF1AN

2.93e-041983741650_DN
DrugGBR 12909 dihydrochloride [67469-78-7]; Down 200; 7.6uM; HL60; HG-U133A

DOCK10 PRPF31 PPIL2 DYRK2

2.93e-041983741625_DN
DrugTocainide hydrochloride; Down 200; 17.4uM; MCF7; HT_HG-U133A

PPIL2 PPARA ALPK1 CDC14B

2.93e-041983744838_DN
DrugPiperidolate hydrochloride [129-77-1]; Down 200; 11.2uM; MCF7; HT_HG-U133A

GRB10 PRPF31 PPIL2 CDC14B

2.93e-041983743551_DN
Drugbuspirone

HTR1A ALPK1 HTR2B

2.98e-0480373CID000002477
Drugsumatriptan

HTR1A ALPK1 HTR2B

2.98e-0480373CID000005358
DrugPyrilamine maleate [59-33-6]; Down 200; 10uM; HL60; HG-U133A

PRPF31 PPIL2 ALPK1 TIMM44

2.98e-041993741568_DN
DrugRimexolone [49697-38-3]; Up 200; 10.8uM; MCF7; HT_HG-U133A

GRB10 PPIL2 CDC14B HIF1AN

2.98e-041993745517_UP
DrugCondelphine [7633-69-4]; Up 200; 8.8uM; PC3; HT_HG-U133A

DIAPH2 PPIL2 PPARA DYRK2

2.98e-041993746357_UP
Drugisamoltane

HTR1A HTR2B

3.04e-0416372CID000127403
Drugpiperazine dihydrochloride

HTR1A HTR2B

3.04e-0416372CID000008893
DrugBenzamides

HTR1A PPARA

3.04e-0416372ctd:D001549
Drug5-nonyloxytryptamine

HTR1A HTR2B

3.04e-0416372CID000001797
Drug1-(3-chlorophenyl)piperazine

HTR1A HTR2B

3.04e-0416372ctd:C015068
DrugWY-14643; Up 200; 100uM; PC3; HG-U133A

DIAPH2 DOCK10 CMKLR1 DYRK2

3.04e-04200374481_UP
DrugHesperidin [520-26-3]; Up 200; 6.6uM; MCF7; HT_HG-U133A

DIAPH2 DOCK10 PLCG2 CDC14B

3.04e-042003742648_UP
DrugGlutethimide, para-amino [125-84-8]; Up 200; 17.2uM; MCF7; HT_HG-U133A

GRB10 PPIL2 ALPK1 TIMM44

3.04e-042003747463_UP
Drug2,5-dimethoxy-4-bromoamphetamine

HTR1A HTR2B

3.44e-0417372CID000062064
Drug5-methyltryptamine

HTR1A HTR2B

3.44e-0417372CID000015760
Drugpsilocybin

HTR1A HTR2B

3.44e-0417372CID000010624
DrugPergolide

HTR1A HTR2B

3.44e-0417372DB01186
Drugzatosetron

HTR1A HTR2B

3.44e-0417372CID000060763
Drugpsilocin

HTR1A HTR2B

3.87e-0418372CID000004980
DrugSB 242084

HTR1A HTR2B

3.87e-0418372CID003644637
DrugBromocriptine

HTR1A HTR2B

3.87e-0418372DB01200
DrugDP-5-CT

HTR1A HTR2B

3.87e-0418372CID000156314
Drugmescaline

HTR1A HTR2B

3.87e-0418372CID000004076
DrugRS 102221

HTR1A HTR2B

3.87e-0418372CID003693566
Drugbenzoctamine

HTR1A HTR2B

3.87e-0418372CID000028425
Drugcyclobutane

HTR1A PPARA

3.87e-0418372CID000009250
DrugpAPP

HTR1A HTR2B

3.87e-0418372CID000121930
DrugDuP 734

HTR1A HTR2B

3.87e-0418372CID000121967
Drugmetolachlor

DIAPH2 PLCG2 DYRK2

3.94e-0488373CID000004169
Drugphenylethylamine

HGD HTR1A HTR2B

4.07e-0489373CID000001001
DrugMDL 11,939

HTR1A HTR2B

4.32e-0419372CID000071781
Drug1-PP

HTR1A HTR2B

4.32e-0419372CID000088747
Drugfemoxitine

HTR1A HTR2B

4.32e-0419372CID000043103
Drugtiospirone

HTR1A HTR2B

4.32e-0419372CID000055751
DrugNSC186067

HTR1A HTR2B

4.32e-0419372CID000004140
Diseasegeneralized anxiety disorder (implicated_via_orthology)

HTR1A HTR2B

4.03e-058362DOID:14320 (implicated_via_orthology)
Diseasekynurenic acid measurement

BZW2 DYRK2

1.12e-0413362EFO_0010506
Diseasediet measurement, fasting blood insulin measurement

HTR1A NRG3

3.29e-0422362EFO_0004466, EFO_0008111
Diseasediet measurement, HOMA-IR

HTR1A NRG3

3.60e-0423362EFO_0004501, EFO_0008111
Diseasefasting blood glucose measurement

DCBLD1 GRB10 NRG3 SLC24A4

4.04e-04287364EFO_0004465
DiseaseSchizophrenia

GRB10 HTR1A PPARA NRG3 IL18R1 CLVS2

6.38e-04883366C0036341
Diseasenicotine withdrawal symptom count

DOCK10 NRG3

8.40e-0435362EFO_0009263
Diseasechronic kidney disease, diabetic nephropathy

NRG3 SLC24A4

8.88e-0436362EFO_0000401, EFO_0003884
Diseasevery long-chain saturated fatty acid measurement

PPARA NPEPPS

1.33e-0344362EFO_0006796
Diseaseinterstitial lung disease

HTR1A NRG3

3.04e-0367362EFO_0004244
Diseaseschizophrenia (implicated_via_orthology)

PPARA NRG3

3.13e-0368362DOID:5419 (implicated_via_orthology)
Diseasewhite matter lesion progression measurement

HTR1A NRG3

3.41e-0371362EFO_0007746
DiseaseCardiac Hypertrophy

PPARA HTR2B

4.52e-0382362C1383860
DiseaseCardiomegaly

PPARA HTR2B

4.52e-0382362C0018800
DiseaseDrug toxicity

PPARA HTR2B

4.74e-0384362C0013221
DiseaseAdverse reaction to drug

PPARA HTR2B

4.74e-0384362C0041755
Diseaseserum iron measurement

PLCG2 SLC24A4

4.96e-0386362EFO_0006332
Diseaselymphocyte:monocyte ratio

DOCK10 GRB10 CMKLR1

5.18e-03288363EFO_0600088
Diseaseage-related hearing impairment

DOCK10 GRB10 HTR1A

7.16e-03324363EFO_0005782

Protein segments in the cluster

PeptideGeneStartEntry
FMKAFQKIVVLFYKA

BZW2

356

Q9Y6E2
YFRNPMAENSKFFKK

HTR2B

416

P41595
VKKAMQYGFLNFNSF

CDC14B

186

O60729
FTYKFNFNKLVMPNY

ETV3

111

P41162
YKLIQCLKAFMNNKF

DIAPH2

231

O60879
KNYMKFKAKFSLIQF

CASP8AP2

1051

Q9UKL3
VKKAMQYGFLNFNSF

CDC14C

156

A4D256
FVSMSKNDYEKFKNN

ALPK1

246

Q96QP1
KYNVKMQAFFTVKQK

SLC24A4

246

Q8NFF2
KFNVSNFYHVKNNMK

PPIL2

166

Q13356
MFCAAFYFKSKKQAK

NRG3

376

P56975
YFFQMKNYTQKWKLN

IL18R1

96

Q13478
KFNFNAYKKEMASFF

PNLIPRP3

261

Q17RR3
FDYMNSQSKFKVKIQ

MAN2A1

446

Q16706
LYYDEKKMANFQNFK

HIF1AN

101

Q9NWT6
YFLNKNKMQEKLFKE

KMT5B

166

Q4FZB7
MKNLKNVFVNFKCYL

FSIP2

686

Q5CZC0
QFHLFYKKLMFEQQK

PLCG2

201

P16885
DFKKGMNMYLTKFQQ

NPEPPSL1

456

A6NEC2
LLYFFMRKNFEFNKQ

DOCK10

1586

Q96BY6
AYFNKDFQNAFKKII

HTR1A

401

P08908
RKNYAKYEFFKNPMN

GRB10

246

Q13322
NFNFYVKSFVMNFKN

DCBLD1

336

Q8N8Z6
MNLYELIKKNKFQGF

DYRK2

306

Q92630
DFKKGMNMYLTKFQQ

NPEPPS

456

P55786
KYNLKNFMVINSVAF

HGD

276

Q93099
YEAYLKNFNMNKVKA

PPARA

211

Q07869
KKMFGKNQVINKVYF

OR5T2

341

Q8NGG2
EEKFQLYMQIINFFK

STRA8

281

Q7Z7C7
YVFMGQDFKKFKVAL

CMKLR1

316

Q99788
KNNSYIKDFFEQMLK

C12orf60

51

Q5U649
FEYRQQNLDMFKSFK

CLVS2

76

Q5SYC1
AKLMGFFDFFKYKYQ

POGLUT3

356

Q7Z4H8
EIQTVFNKYMKFFQK

DNTTIP1

81

Q9H147
FNKYMKFFQKAALNV

DNTTIP1

86

Q9H147
NQKYFSSMAEFLKVK

PRPF31

476

Q8WWY3
NNVVFNRFFEMKMKY

TIMM44

251

O43615
FSIRDNFMQQKAFKY

XKR3

151

Q5GH77
QDSKKFLKIMFSYNN

TRBV3-1

56

A0A576