Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	microtubule-based process	DNAH3 INTU DCTN2 TTLL5 APBA1 SIK3 CUL7 CDC14A KIF20B CEP350 PARD6B CCDC66 DST ALMS1 BRCA2 SLC22A16 ARHGEF10 CCSER2 DIAPH1 RP1 POLDIP2 CFAP61 PLK3 DYNC1H1 INVS DNAH11	1.14e-06	1058	176	26	GO:0007017
GeneOntologyCellularComponent	centrosome	DCTN2 HIPK1 TTLL5 CDH23 CUL7 CDC14A KIF20B MKS1 CEP350 LHCGR EYS CCDC66 ALMS1 TIAM1 BRCA2 ARHGEF10 DIAPH1 HYLS1 PLK3 DYNC1H1	1.58e-05	770	184	20	GO:0005813
GeneOntologyCellularComponent	microtubule organizing center	INTU DCTN2 HIPK1 TTLL5 CDH23 CUL7 CDC14A KIF20B MKS1 CEP350 LHCGR EYS CCDC66 ALMS1 TIAM1 BRCA2 ARHGEF10 DIAPH1 HYLS1 PLK3 DYNC1H1 SMTNL2	2.05e-05	919	184	22	GO:0005815
GeneOntologyCellularComponent	non-motile cilium	TTLL5 CDH23 CDC14A EYS CCDC66 TIAM1 HYLS1 RP1 CNGA1	6.21e-05	196	184	9	GO:0097730
GeneOntologyCellularComponent	9+2 non-motile cilium	CDH23 CDC14A TIAM1	2.27e-04	14	184	3	GO:0097732
GeneOntologyCellularComponent	kinocilium	CDH23 CDC14A TIAM1	2.27e-04	14	184	3	GO:0060091
GeneOntologyCellularComponent	TEAD-YAP complex	TEAD1 YAP1	2.30e-04	3	184	2	GO:0140552
GeneOntologyCellularComponent	photoreceptor inner segment	USP45 CDH23 CCDC66 RP1 ATP1A3	6.28e-04	78	184	5	GO:0001917
GeneOntologyCellularComponent	cluster of actin-based cell projections	TRPM6 CDH23 ACTN3 PKHD1L1 CDC14A TIAM1 PIK3CB DIAPH1	8.30e-04	223	184	8	GO:0098862
GeneOntologyCellularComponent	stereocilium tip	CDH23 PKHD1L1 CDC14A	9.13e-04	22	184	3	GO:0032426
MousePheno	abnormal eye physiology	RELN USP45 MAGED1 TTLL5 CDH23 TSHR ITGB2 LEPR ADGRL4 CCDC66 DST ALMS1 YAP1 TMEM145 SNAI2 HSD3B1 RP1 GNAO1 STRA6 CNGA1 PTCD3	2.76e-06	606	153	21	MP:0005253
MousePheno	abnormal rhythmic behavior	MAGED1 NOX3 GRIA3 TSHR SIK3 ZZEF1 TFAP2B FBXL3 LEPR LRRC7 ATP1A3	1.49e-05	204	153	11	MP:0021121
MousePheno	abnormal retina cone cell morphology	USP45 TTLL5 CCDC66 YAP1 RP1 STRA6 CNGA1	2.08e-05	77	153	7	MP:0001006
MousePheno	abnormal circadian behavior	MAGED1 NOX3 SIK3 TFAP2B FBXL3 LEPR ATP1A3	3.67e-05	84	153	7	MP:0020467
MousePheno	retina cone cell degeneration	CCDC66 YAP1 RP1 STRA6 CNGA1	4.22e-05	36	153	5	MP:0008444
MousePheno	abnormal cone electrophysiology	RELN USP45 TSHR CCDC66 RP1 GNAO1 STRA6	9.87e-05	98	153	7	MP:0004022
MousePheno	abnormal paradoxical sleep pattern	TSHR SIK3 TFAP2B ATP1A3	1.04e-04	23	153	4	MP:0012288
Domain	PDZ	INTU SHROOM3 APBA1 PARD6B PTPN13 TIAM1 LRRC7 RIMS1	8.47e-05	148	177	8	SM00228
Domain	EIF3C_N_dom	EIF3CL EIF3C	8.93e-05	2	177	2	IPR008905
Domain	eIF-3c_N	EIF3CL EIF3C	8.93e-05	2	177	2	PF05470
Domain	EIF3C	EIF3CL EIF3C	8.93e-05	2	177	2	IPR027516
Domain	-	INTU SHROOM3 APBA1 PARD6B PTPN13 TIAM1 LRRC7 RIMS1	9.31e-05	150	177	8	2.30.42.10
Domain	PDZ	INTU SHROOM3 APBA1 PARD6B PTPN13 TIAM1 LRRC7 RIMS1	9.75e-05	151	177	8	PS50106
Domain	PDZ	INTU SHROOM3 APBA1 PARD6B PTPN13 TIAM1 LRRC7 RIMS1	1.02e-04	152	177	8	IPR001478
Domain	EGF-like_CS	RELN ADAM21 ITGB2 ADGRL4 EYS FAT2 SCUBE2 ASTN1 C6 PROC	1.99e-04	261	177	10	IPR013032
Domain	EGF_2	RELN ADAM21 ITGB2 ADGRL4 EYS FAT2 SCUBE2 ASTN1 C6 PROC	2.25e-04	265	177	10	PS01186
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DYNC1H1 DNAH11	2.82e-04	14	177	3	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DYNC1H1 DNAH11	2.82e-04	14	177	3	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DYNC1H1 DNAH11	2.82e-04	14	177	3	IPR013602
Domain	DHC_N2	DNAH3 DYNC1H1 DNAH11	2.82e-04	14	177	3	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH3 DYNC1H1 DNAH11	2.82e-04	14	177	3	IPR011704
Domain	MT	DNAH3 DYNC1H1 DNAH11	2.82e-04	14	177	3	PF12777
Domain	AAA_8	DNAH3 DYNC1H1 DNAH11	2.82e-04	14	177	3	PF12780
Domain	AAA_5	DNAH3 DYNC1H1 DNAH11	2.82e-04	14	177	3	PF07728
Domain	DHC_fam	DNAH3 DYNC1H1 DNAH11	3.50e-04	15	177	3	IPR026983
Domain	Dynein_heavy	DNAH3 DYNC1H1 DNAH11	3.50e-04	15	177	3	PF03028
Domain	Dynein_heavy_dom	DNAH3 DYNC1H1 DNAH11	3.50e-04	15	177	3	IPR004273
Domain	PDZ	SHROOM3 APBA1 PARD6B PTPN13 TIAM1 LRRC7 RIMS1	3.97e-04	141	177	7	PF00595
Domain	EGF_3	RELN ADAM21 ADGRL4 EYS FAT2 SCUBE2 ASTN1 C6 PROC	4.16e-04	235	177	9	PS50026
Domain	Nebulin	NRAP NEB	5.29e-04	4	177	2	PF00880
Domain	ART	ART1 ART3	5.29e-04	4	177	2	IPR000768
Domain	NEBULIN	NRAP NEB	5.29e-04	4	177	2	PS51216
Domain	NEBU	NRAP NEB	5.29e-04	4	177	2	SM00227
Domain	Nebulin	NRAP NEB	5.29e-04	4	177	2	IPR013998
Domain	Nebulin_repeat	NRAP NEB	5.29e-04	4	177	2	IPR000900
Domain	ART	ART1 ART3	5.29e-04	4	177	2	PS01291
Domain	ART	ART1 ART3	5.29e-04	4	177	2	PF01129
Domain	EGF-like_dom	RELN ADAM21 ADGRL4 EYS FAT2 SCUBE2 ASTN1 C6 PROC	6.32e-04	249	177	9	IPR000742
Domain	EGF_1	RELN ADAM21 ITGB2 EYS FAT2 SCUBE2 ASTN1 C6 PROC	7.48e-04	255	177	9	PS00022
Domain	Cupredoxin	PRPF8 PKHD1L1 EFNA1	1.13e-03	22	177	3	IPR008972
Domain	Gphrmn_rcpt_fam	TSHR LHCGR	1.31e-03	6	177	2	IPR002131
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	INTU BEND3 SIK3 CUL7 RALGAPA2 ANKHD1 ZZEF1 P3H4 NKRF ZNF518A TYK2 DAP3 NAA35 TAF8 ALMS1 MCM3AP CPEB4 DIAPH1 RARS2 BICRAL POLDIP2 ZNF687 PTCD3	2.67e-08	1116	183	23	31753913
Pubmed	Human transcription factor protein interaction networks.	TCF4 EDC3 MAGED1 RPN1 MAP3K8 IARS1 BEND3 GCM1 TEAD1 CUL7 ANKHD1 NKRF ZNF462 DAP3 KMT2C TAF8 DST ALMS1 YAP1 PPIL2 EIF3C POLDIP2 DYNC1H1 ZNF687 PTCD3	1.48e-07	1429	183	25	35140242
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RELN MAGED1 SYNM HIPK1 TTLL5 APBA1 PARVB ZFC3H1 PRPF8 CEP350 RNF123 EFNA1 PTPN13 DST TIAM1 COG1 ARHGEF10 ASTN1 EIF3C POLDIP2 MORC3 HSPA2 DYNC1H1	3.29e-07	1285	183	23	35914814
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CASP8AP2 SIK3 ZBTB24 ZNF518A ZNF462 KMT2C DST ALMS1 ARHGEF10 PCNX1	3.58e-07	225	183	10	12168954
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	DCTN2 TTLL5 BABAM2 ZBTB24 CEP350 CCDC66 DST ALMS1 DIAPH1 PPIL2 GNAO1 POLDIP2 MORC3 EDRF1 ZNF687 PTCD3	3.60e-07	645	183	16	25281560
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	DNAH3 EDC3 RPN1 IARS1 PRPF8 ZZEF1 IGSF10 KMT2C RNF123 SAMD9L DST SLC22A16 MCM3AP LRRC7 C6 BANK1 DYNC1H1	4.13e-07	736	183	17	29676528
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	CASP8AP2 MAGED1 HIPK1 CUL7 IPO4 KIF20B ALMS1 BRCA2 YAP1 MCM3AP DIAPH1 PPIL2 MORC3 SPRTN PLRG1	5.97e-07	588	183	15	38580884
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CASP8AP2 SHROOM3 MAGED1 SYNM RPN1 DCTN2 TTLL5 SMPD4 ZFC3H1 SIK3 IPO4 PRPF8 DAP3 NAA35 PTPN13 TIAM1 ARHGEF10 EIF2B4 CCSER2 POLDIP2 HSPA2 PLRG1 EDRF1 PTCD3	1.12e-06	1487	183	24	33957083
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	EDC3 MAGED1 RPN1 IARS1 SMPD4 PARVB IPO4 PRPF8 BABAM2 ZBTB24 DAP3 KMT2C RNF123 TIAM1 IKBKE YAP1 RARS2 LRRC7 RIMS1 PLRG1 DYNC1H1 PTCD3	1.24e-06	1284	183	22	17353931
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	PPP1R21 CUL7 IPO4 NEB KMT2C PTPN13 DST COG1 ATP1A3 TM4SF1 DYNC1H1	1.25e-06	322	183	11	26514267
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SYNM CC2D1B ZFC3H1 CUL7 RALGAPA2 CEP350 ZNF462 FAT2 SAMD9L ALMS1 CPEB4 MORC3 KLHL14	2.40e-06	493	183	13	15368895
Pubmed	Joint analysis of candidate genes related to Alzheimer's disease in a Spanish population.	SERPINA3 IL1A HSPA2	2.83e-06	6	183	3	12782964
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	DCTN2 APBA1 ZFC3H1 DST ALMS1 CCSER2 DYNC1H1	3.59e-06	120	183	7	31413325
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	DNAH3 HIPK1 ANKHD1 NKRF DAP3 KMT2C DST ALMS1 DNAH11	4.41e-06	233	183	9	37704626
Pubmed	Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.	CDH23 PRPF8 ALMS1 RP1 RIMS1 CNGA1	6.93e-06	87	183	6	20801516
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	CASP8AP2 NEB ZBTB24 DST PPIL2 EIF3C	9.58e-06	92	183	6	15840729
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	SERPINA3 COL6A3 TCN1 ITGB2 LEPR ADGRL4 FAT2 C6 PROC	9.71e-06	257	183	9	16335952
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	DCTN2 TTLL5 CDC14A CEP350 ALMS1 HYLS1 DYNC1H1	1.30e-05	146	183	7	21399614
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	CASP8AP2 TFDP3 BEND3 ANKHD1 KIF20B ZNF462 PTPN13 DST ALMS1 BRCA2 ZNF687	1.49e-05	418	183	11	34709266
Pubmed	Functional proteomics mapping of a human signaling pathway.	MAN1C1 HIPK1 ZZEF1 ZNF518A RNF123 PTPN12 DST MCM3AP DIAPH1 EIF3C SPRTN DYNC1H1 INVS	1.67e-05	591	183	13	15231748
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	DENND5B EDC3 NBEAL1 DCTN2 AGGF1 SIK3 IPO4 KIF20B CEP350 DAP3 KMT2C FAM111A VASP DNAH11	1.90e-05	689	183	14	36543142
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SYNM ZNF518A ALMS1 ARHGEF10 RIMS1 DYNC1H1	1.93e-05	104	183	6	9205841
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	PALD1 INTU EDC3 DCTN2 IARS1 CDH23 IPO4 PRPF8 NKRF MKS1 EIF3CL PTPN13 TIAM1 YAP1 EIF2B4 MORC3 VASP EDRF1 DYNC1H1 INVS	2.36e-05	1321	183	20	27173435
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CASP8AP2 SHROOM3 SZT2 SMPD4 SIK3 ANKHD1 ZZEF1 KMT2C DST CCSER2 PCNX1 ZNF687	2.63e-05	529	183	12	14621295
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	SHROOM3 EDC3 MAGED1 TEAD1 CUL7 PTPN13 DST ALMS1 YAP1 CPEB4 CCSER2	2.70e-05	446	183	11	24255178
Pubmed	Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease.	TEAD1 YAP1	2.75e-05	2	183	2	27359056
Pubmed	ANKHD1, a novel component of the Hippo signaling pathway, promotes YAP1 activation and cell cycle progression in prostate cancer cells.	ANKHD1 YAP1	2.75e-05	2	183	2	24726915
Pubmed	LHCGR and ALMS1 defects likely cooperate in the development of polycystic ovary syndrome indicated by double-mutant mice.	LHCGR ALMS1	2.75e-05	2	183	2	34147365
Pubmed	TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.	TEAD1 YAP1	2.75e-05	2	183	2	25915126
Pubmed	YAP1 contributes to NSCLC invasion and migration by promoting Slug transcription via the transcription co-factor TEAD.	YAP1 SNAI2	2.75e-05	2	183	2	29700328
Pubmed	Neutrophil beta2 integrin inhibition by enhanced interactions of vasodilator-stimulated phosphoprotein with S-nitrosylated actin.	ITGB2 VASP	2.75e-05	2	183	2	21795685
Pubmed	VASP increases hepatic fatty acid oxidation by activating AMPK in mice.	LEPR VASP	2.75e-05	2	183	2	23349495
Pubmed	TCR-induced activation of LFA-1 involves signaling through Tiam1.	ITGB2 TIAM1	2.75e-05	2	183	2	21876037
Pubmed	Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway.	ATG7 LEPR	2.75e-05	2	183	2	30653446
Pubmed	BRCA2 suppresses cell proliferation via stabilizing MAGE-D1.	MAGED1 BRCA2	2.75e-05	2	183	2	15930293
Pubmed	LepRb+ cell-specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice.	LEPR SNAI2	2.75e-05	2	183	2	36512408
Pubmed	YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors.	TEAD1 YAP1	2.75e-05	2	183	2	26173433
Pubmed	YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers.	TEAD1 YAP1	2.75e-05	2	183	2	26295846
Pubmed	Structural insights into the YAP and TEAD complex.	TEAD1 YAP1	2.75e-05	2	183	2	20123905
Pubmed	Mechanism of nodal flow: a conserved symmetry breaking event in left-right axis determination.	INVS DNAH11	2.75e-05	2	183	2	15907475
Pubmed	Visualizing HIPPO Signaling Components in Mouse Early Embryonic Development.	PARD6B YAP1	2.75e-05	2	183	2	30565145
Pubmed	An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.	TSHR LHCGR	2.75e-05	2	183	2	18162522
Pubmed	A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor.	TSHR LHCGR	2.75e-05	2	183	2	11312274
Pubmed	YAP regulates neural progenitor cell number via the TEA domain transcription factor.	TEAD1 YAP1	2.75e-05	2	183	2	19015275
Pubmed	IKKε is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity.	LEPR IKBKE	2.75e-05	2	183	2	24812431
Pubmed	Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis.	LEPR ALMS1	2.75e-05	2	183	2	28842428
Pubmed	Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides.	TEAD1 YAP1	2.75e-05	2	183	2	25384421
Pubmed	Insights into differential modulation of receptor function by hinge region using novel agonistic lutropin receptor and inverse agonistic thyrotropin receptor antibodies.	TSHR LHCGR	2.75e-05	2	183	2	22309849
Pubmed	High levels of intracellular endotrophin in adipocytes mediate COPII vesicle supplies to autophagosome to impair autophagic flux and contribute to systemic insulin resistance in obesity.	COL6A3 LEPR	2.75e-05	2	183	2	37302692
Pubmed	Extragonadal teratocarcinoma in chimeric mice.	BRCA2 HSPA2	2.75e-05	2	183	2	10490215
Pubmed	Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing.	TSHR LHCGR	2.75e-05	2	183	2	2293030
Pubmed	IKBKE and BANK1 Polymorphisms and Clinical Characteristics in Chinese Women with Systemic Lupus Erythematosus.	IKBKE BANK1	2.75e-05	2	183	2	35930382
Pubmed	Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells.	BRCA2 SNAI2	2.75e-05	2	183	2	15734731
Pubmed	EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.	EIF3CL EIF3C	2.75e-05	2	183	2	36157221
Pubmed	Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy.	TEAD1 YAP1	2.75e-05	2	183	2	30903741
Pubmed	Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP.	TEAD1 YAP1	2.75e-05	2	183	2	24882516
Pubmed	TM4SF1 facilitates non-small cell lung cancer progression through regulating YAP-TEAD pathway.	YAP1 TM4SF1	2.75e-05	2	183	2	32141552
Pubmed	Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding.	TSHR LHCGR	2.75e-05	2	183	2	1651314
Pubmed	ANKHD1 promotes proliferation and invasion of non‑small‑cell lung cancer cells via regulating YAP oncoprotein expression and inactivating the Hippo pathway.	ANKHD1 YAP1	2.75e-05	2	183	2	32319569
Pubmed	Angiogenic Factor AGGF1-Primed Endothelial Progenitor Cells Repair Vascular Defect in Diabetic Mice.	AGGF1 LEPR	2.75e-05	2	183	2	31092480
Pubmed	YAP-TEAD1 control of cytoskeleton dynamics and intracellular tension guides human pluripotent stem cell mesoderm specification.	TEAD1 YAP1	2.75e-05	2	183	2	33116297
Pubmed	YAP1-TEAD1 mediates the perineural invasion of prostate cancer cells induced by cancer-associated fibroblasts.	TEAD1 YAP1	2.75e-05	2	183	2	36100154
Pubmed	TEAD1 mediates the oncogenic activities of Hippo-YAP1 signaling in osteosarcoma.	TEAD1 YAP1	2.75e-05	2	183	2	28483529
Pubmed	Pivotal role for alpha1-antichymotrypsin in skin repair.	SERPINA3 LEPR	2.75e-05	2	183	2	21693707
Pubmed	Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking.	TEAD1 YAP1	2.75e-05	2	183	2	30640473
Pubmed	Mutational analysis of FLASH and PTPN13 genes in colorectal carcinomas.	CASP8AP2 PTPN13	2.75e-05	2	183	2	18038312
Pubmed	Abnormal nodal flow precedes situs inversus in iv and inv mice.	INVS DNAH11	2.75e-05	2	183	2	10549278
Pubmed	The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.	TEAD1 YAP1	2.75e-05	2	183	2	21808241
Pubmed	Amelogenesis imperfecta in a new animal model--a mutation in chromosome 5 (human 4q21).	SHROOM3 ENAM ART3	3.04e-05	12	183	3	15271968
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	COL6A3 PRPF8 KIF20B EIF3CL EIF3C GNAO1 HSPA2 PTCD3	3.31e-05	231	183	8	36597993
Pubmed	Host PDZ-containing proteins targeted by SARS-CoV-2.	APBA1 PTPN13 LRRC7 RIMS1	3.42e-05	35	183	4	33864728
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	RPN1 DCTN2 BEND3 TEAD1 ANKHD1 NKRF KMT2C PTPN13 ALMS1 YAP1 OSBPL11 DYNC1H1	3.77e-05	549	183	12	38280479
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	MAGED1 BEND3 NKRF ZNF462 KMT2C PTPN12 ALMS1 POLDIP2 MORC3 PLRG1 PTCD3	4.25e-05	469	183	11	27634302
Pubmed	YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes.	TEAD1 TLR8 YAP1	5.00e-05	14	183	3	34206257
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH3 DYNC1H1 DNAH11	5.00e-05	14	183	3	9373155
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SHROOM3 EDC3 SIK3 CDC14A CEP350 PTPN13 DST ALMS1 TIAM1 ARHGEF10 IKBKE YAP1 CCSER2 MORC3 EDRF1	5.56e-05	861	183	15	36931259
Pubmed	Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.	SHROOM3 RPN1 MAP3K8 ZFC3H1 TYK2 PARD6B DST IKBKE EIF3C HSPA2	5.73e-05	401	183	10	25852190
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	EDC3 SYNM TTLL5 BEND3 CEP350 ALMS1 MCM3AP	5.74e-05	184	183	7	32908313
Pubmed	A human MAP kinase interactome.	CASP8AP2 DCTN2 HIPK1 SIK3 NEB CEP350 PARD6B KMT2C DST MCM3AP BICRAL	5.85e-05	486	183	11	20936779
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	RELN RPN1 SMPD4 SIK3 PRPF8 NKRF ZNF462 DAP3 PTPN13 DST CPEB4 PPIL2 EIF3C POLDIP2 PLRG1 DYNC1H1 PTCD3	6.34e-05	1082	183	17	38697112
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	COL6A3 ZFC3H1 ZZEF1 DST ALMS1 EIF3C HSPA2	6.36e-05	187	183	7	26460568
Pubmed	Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.	ATG7 RPN1 TTC39C PRPF8 EIF3CL DST EIF3C C6 VASP	6.70e-05	329	183	9	34316702
Pubmed	KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.	NRAP CC2D1B NEB	7.63e-05	16	183	3	24960163
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	MAGED1 SYNM SMPD4 PTPN13 ALMS1 CPEB4 CCSER2 LRRC7	8.22e-05	263	183	8	34702444
Pubmed	MRTF potentiates TEAD-YAP transcriptional activity causing metastasis.	TEAD1 YAP1	8.23e-05	3	183	2	28028053
Pubmed	The feedback loop of ANKHD1/lncRNA MALAT1/YAP1 strengthens the radioresistance of CRC by activating YAP1/AKT signaling.	ANKHD1 YAP1	8.23e-05	3	183	2	35110552
Pubmed	Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity.	TSHR LHCGR	8.23e-05	3	183	2	15889138
Pubmed	The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.	DIAPH1 VASP	8.23e-05	3	183	2	7737110
Pubmed	Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival.	TEAD1 YAP1	8.23e-05	3	183	2	25628125
Pubmed	YAP1-TEAD1 signaling controls angiogenesis and mitochondrial biogenesis through PGC1α.	TEAD1 YAP1	8.23e-05	3	183	2	29680477
Pubmed	Complement receptor 3 influences toll-like receptor 7/8-dependent inflammation: implications for autoimmune diseases characterized by antibody reactivity to ribonucleoproteins.	ITGB2 TLR8	8.23e-05	3	183	2	23386618
Pubmed	Nuclear actin regulates cell proliferation and migration via inhibition of SRF and TEAD.	TEAD1 YAP1	8.23e-05	3	183	2	32119877
Pubmed	High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP.	DIAPH1 VASP	8.23e-05	3	183	2	18001770
Pubmed	IKBKE promotes glioblastoma progression by establishing the regulatory feedback loop of IKBKE/YAP1/miR-Let-7b/i.	IKBKE YAP1	8.23e-05	3	183	2	28677425
Pubmed	Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload.	TEAD1 YAP1	8.23e-05	3	183	2	30582455
Pubmed	Retinal Degeneration Triggers the Activation of YAP/TEAD in Reactive Müller Cells.	TEAD1 YAP1	8.23e-05	3	183	2	28384715
Pubmed	Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus.	INVS DNAH11	8.23e-05	3	183	2	8610013
Pubmed	Interaction with the Yes-associated protein (YAP) allows TEAD1 to positively regulate NAIP expression.	TEAD1 YAP1	8.23e-05	3	183	2	23994529
Pubmed	A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity.	DIAPH1 VASP	8.23e-05	3	183	2	12805219
Pubmed	Vasodilator-stimulated phosphoprotein protects against vascular inflammation and insulin resistance.	LEPR VASP	8.23e-05	3	183	2	25117404
GeneFamily	PDZ domain containing	INTU SHROOM3 APBA1 PARD6B PTPN13 TIAM1 LRRC7 RIMS1	9.44e-06	152	123	8	1220
GeneFamily	Glycoprotein hormone receptors	TSHR LHCGR	1.37e-04	3	123	2	199
ToppCell	Control-Epithelial\|Control / Disease state, Lineage and Cell class	SHROOM3 ABCA3 TEAD1 PARD6B EFNA1 PTPN13 YAP1 TMPRSS2 TMC5 TM4SF1 LRRC36 ACOXL	3.56e-11	195	184	12	1798c3b89b1b5ff4f5777d2b9f52dc81cdad28fa
ToppCell	COPD-Epithelial-Club\|World / Disease state, Lineage and Cell class	SHROOM3 TEAD1 PARD6B EFNA1 PTPN13 YAP1 TMPRSS2 RP1 TMC5 TM4SF1 ACOXL	3.64e-10	186	184	11	3006f4ab1eaf1eb34c10ca9f7c869603d2d25744
ToppCell	COPD-Epithelial-Club\|COPD / Disease state, Lineage and Cell class	SHROOM3 TEAD1 PARD6B EFNA1 PTPN13 YAP1 TMPRSS2 RP1 TMC5 TM4SF1 ACOXL	4.83e-10	191	184	11	c909cf5fa0e6519aa93a47d2c3fcd2ae2163cd8d
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM3 ABCA3 TEAD1 PARD6B PTPN13 YAP1 TMPRSS2 RP1 TMC5 LRRC36 ACOXL	4.83e-10	191	184	11	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	COPD-Epithelial-ATII\|World / Disease state, Lineage and Cell class	SHROOM3 ABCA3 TEAD1 PARD6B PTPN13 YAP1 TMPRSS2 TMC5 LRRC36 ACOXL	5.02e-09	183	184	10	8e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell	Control-Epithelial-Club\|World / Disease state, Lineage and Cell class	SHROOM3 TEAD1 PARD6B EFNA1 PTPN13 YAP1 TMPRSS2 TMC5 TM4SF1 ACOXL	5.87e-09	186	184	10	9798428691408e17ff2af2fe2d1b345f074d67e4
ToppCell	Control-Epithelial-ATII\|World / Disease state, Lineage and Cell class	SHROOM3 ABCA3 TEAD1 PARD6B PTPN13 YAP1 TMPRSS2 TM4SF1 LRRC36 ACOXL	5.87e-09	186	184	10	f4b6e401e19a71beddc73d8a1e08359f7c4025cf
ToppCell	COPD-Epithelial-ATII\|COPD / Disease state, Lineage and Cell class	SHROOM3 ABCA3 TEAD1 PARD6B PTPN13 YAP1 TMPRSS2 TMC5 LRRC36 ACOXL	6.50e-09	188	184	10	eb6d79d733b53f64ca615bb777c64ed456866549
ToppCell	Control-Epithelial-ATII\|Control / Disease state, Lineage and Cell class	SHROOM3 ABCA3 TEAD1 PARD6B PTPN13 YAP1 TMPRSS2 TM4SF1 LRRC36 ACOXL	7.20e-09	190	184	10	d50902a3abcc18aafa36d83cc2c6e07d7f7cb197
ToppCell	Control-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	SHROOM3 ABCA3 TEAD1 PARD6B PTPN13 YAP1 TMPRSS2 TMC5 TM4SF1 ACOXL	7.96e-09	192	184	10	1bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCell	Control-Multiplet-Multiplet\|Control / Disease state, Lineage and Cell class	SHROOM3 ABCA3 TEAD1 PARD6B PTPN13 YAP1 TMPRSS2 TMC5 TM4SF1 ACOXL	9.23e-09	195	184	10	06ac685855e14e4dd2cbe6d0e73f894f2eeff91f
ToppCell	Control-Multiplet\|Control / Disease state, Lineage and Cell class	SHROOM3 ABCA3 TEAD1 PARD6B PTPN13 YAP1 TMPRSS2 TMC5 TM4SF1 ACOXL	9.23e-09	195	184	10	618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 ABCA3 PARD6B PTPN13 FGD4 YAP1 TMPRSS2 TMC5 LRRC36 ACOXL	1.12e-08	199	184	10	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	SHROOM3 ABCA3 PARD6B PTPN13 TMPRSS2 RP1 TMC5 ACOXL DNAH11	9.34e-08	188	184	9	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	SHROOM3 ABCA3 NBEAL1 TEAD1 PTPN13 TMPRSS2 TMC5 LRRC36 ACOXL	9.34e-08	188	184	9	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	IPF-Epithelial-Club\|IPF / Disease state, Lineage and Cell class	SHROOM3 PARD6B PTPN13 YAP1 TMPRSS2 RIMS1 TMC5 TM4SF1 ACOXL	9.77e-08	189	184	9	f3fcef008ef252b29ac6d567fef27f9acf9cd70f
ToppCell	IPF-Epithelial-Club\|World / Disease state, Lineage and Cell class	SHROOM3 TEAD1 PARD6B PTPN13 YAP1 TMPRSS2 RIMS1 TMC5 TM4SF1	1.07e-07	191	184	9	3c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCell	COPD-Epithelial\|COPD / Disease state, Lineage and Cell class	SHROOM3 TEAD1 PARD6B EFNA1 YAP1 TMPRSS2 RP1 TMC5 TM4SF1	1.12e-07	192	184	9	0644fad5df18f0021f6f49cca996d8cf47f972ff
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	SHROOM3 ABCA3 TEAD1 PARD6B PTPN13 YAP1 TMPRSS2 TMC5 ACOXL	1.12e-07	192	184	9	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM3 ABCA3 TEAD1 PARD6B PTPN13 YAP1 TMPRSS2 TMC5 ACOXL	1.22e-07	194	184	9	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM3 ABCA3 TEAD1 PARD6B PTPN13 YAP1 TMPRSS2 TMC5 ACOXL	1.28e-07	195	184	9	9406866f99555198a9be311fbd65751b70f35446
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-B-Plasmablast\|COVID-19_Severe / Disease, condition lineage and cell class	DENND5B MAGED1 RPN1 MANEA TSHR PKHD1L1 ENAM KLHL14 ACOXL	1.52e-07	199	184	9	e6422b65e22e5aa8dfaebdae5be76dd78b978604
ToppCell	Lung_Parenchyma-Control-Epithelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SHROOM3 ABCA3 PARD6B EFNA1 PTPN13 YAP1 TMPRSS2 TMC5 LRRC36	1.58e-07	200	184	9	c2bde99b3bc7a8740441c1a0c1394892b940b857
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SHROOM3 ABCA3 PARD6B EFNA1 PTPN13 YAP1 TMPRSS2 TMC5 LRRC36	1.58e-07	200	184	9	3ff9abd5e07780a59d5571da906fa15f00a1d5c2
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	SHROOM3 ABCA3 PARD6B EFNA1 PTPN13 YAP1 TMPRSS2 TMC5 LRRC36	1.58e-07	200	184	9	9970e9bde6aa2ff3aef60dcb065ff15b7463e147
ToppCell	Basal_cells-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	TRPM6 GABRP TCF4 MAN1C1 SNAI2 STRA6 ATP1A3 HSPA2	4.06e-07	163	184	8	679e25e5548d157d49a73057a3b5617dccda260f
ToppCell	BL-critical-LOC-Lymphoid-PC\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DENND5B TCF4 MANEA TSHR PKHD1L1 ENAM KLHL14 ACOXL	6.39e-07	173	184	8	90700a876d997f7c0f7b3899dffcda7fdafee547
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASP8AP2 NBEAL1 NUP210L ADGRL4 SAMD9L CPEB4 DIAPH1 TAP2	7.92e-07	178	184	8	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Monocytes\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LILRA1 TCN1 MAP3K8 ZNF267 CLEC7A ITGB2 STXBP2 IL1A	8.98e-07	181	184	8	bad77767e64cc093a827a6b0f3f401f3f108e457
ToppCell	IPF-Epithelial-ATII\|World / Disease state, Lineage and Cell class	SHROOM3 ABCA3 PARD6B EFNA1 PTPN13 YAP1 TMPRSS2 ACOXL	1.10e-06	186	184	8	6a4ff2da0af0f5e590d9f9daa5b5e9ac8c868947
ToppCell	mild_COVID-19-Plasmablast\|mild_COVID-19 / disease group, cell group and cell class (v2)	DENND5B MAGED1 MANEA TSHR PKHD1L1 ENAM KLHL14 ACOXL	1.10e-06	186	184	8	a639d2183b85b1be6e6da2b2e112aec5149d5bcd
ToppCell	B_cells-Plasma_cells_and_plasmablasts\|World / Immune cells in Kidney/Urine in Lupus Nephritis	DENND5B MAGED1 CCDC110 MANEA TSHR PKHD1L1 ENAM ACOXL	1.15e-06	187	184	8	9325cadd5f2c667d526696899e7aa36a98226d4b
ToppCell	mild-Lymphocytic-Plasmablast\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	DENND5B TCF4 RPN1 MANEA PKHD1L1 ENAM KLHL14 ACOXL	1.24e-06	189	184	8	db2097e6e165004d47ed504e115083a4e4f4b147
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DENND5B MAGED1 RPN1 MANEA PKHD1L1 ENAM KLHL14 ACOXL	1.29e-06	190	184	8	84eb7761f537d270673909a71d4f122e826769d5
ToppCell	PBMC-Convalescent-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DENND5B TCF4 RPN1 MANEA TSHR PKHD1L1 ENAM KLHL14	1.35e-06	191	184	8	dd1d38a531a272a746c16807688013d29cab823a
ToppCell	COVID-19_Moderate-Plasmablast\|World / disease group, cell group and cell class	DENND5B MANEA TSHR PKHD1L1 ENAM CPEB4 KLHL14 ACOXL	1.35e-06	191	184	8	bb28703020c5296b65527094d2e5924348275e58
ToppCell	Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|World / Lineage, Cell type, age group and donor	SHROOM3 NBEAL1 EFNA1 PTPN13 YAP1 TMPRSS2 TMC5 ACOXL	1.35e-06	191	184	8	d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	SHROOM3 ABCA3 PARD6B PTPN13 YAP1 TMPRSS2 TMC5 ACOXL	1.40e-06	192	184	8	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	COVID-19_Severe-Lymphoid_P\|COVID-19_Severe / Disease group, lineage and cell class	DENND5B MAGED1 RPN1 MANEA PKHD1L1 ENAM KLHL14 ACOXL	1.40e-06	192	184	8	3d0240491296757b3125f6e861bbaca06bbc5068
ToppCell	Control-Epithelial-Club\|Control / Disease state, Lineage and Cell class	SHROOM3 TEAD1 PARD6B PTPN13 YAP1 TMPRSS2 TMC5 ACOXL	1.40e-06	192	184	8	d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCell	COVID-19_Moderate-Plasmablast\|COVID-19_Moderate / disease group, cell group and cell class	DENND5B RPN1 MANEA TSHR PKHD1L1 ENAM CPEB4 KLHL14	1.40e-06	192	184	8	25c6c7a244190f82c7feab874bdec12490b7de4d
ToppCell	COVID-19_Severe-Plasmablast\|World / disease group, cell group and cell class	DENND5B MAGED1 MANEA TSHR PKHD1L1 ENAM KLHL14 ACOXL	1.40e-06	192	184	8	a333053fe2bd206c32790916bfc5fce904ab7f57
ToppCell	COVID-19_Severe-Lymphoid_P-Plasmablast\|COVID-19_Severe / Disease group, lineage and cell class	DENND5B MAGED1 RPN1 MANEA PKHD1L1 ENAM KLHL14 ACOXL	1.40e-06	192	184	8	90af8dad4e6f80b5ecd62027deeb2e4cea6b24bb
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	DENND5B MAGED1 RPN1 MANEA PKHD1L1 ENAM KLHL14 ACOXL	1.45e-06	193	184	8	227d82059a9f99937e0188ff57f2d0e485ebfe69
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Monocytes\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	LILRA1 MAP3K8 P2RY13 CLEC7A ITGB2 TLR8 STXBP2 IL1A	1.45e-06	193	184	8	ddbd8944661ac3b0b5fe63471bdc24ba05598017
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM3 ABCA3 PTPN13 YAP1 TMPRSS2 TMC5 LRRC36 ACOXL	1.45e-06	193	184	8	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DENND5B MAGED1 RPN1 MANEA PKHD1L1 ENAM KLHL14 ACOXL	1.45e-06	193	184	8	ce3873ece35fd2155ea235cb3c8bcd235cc0ebde
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DENND5B MAGED1 RPN1 MANEA PKHD1L1 ENAM KLHL14 ACOXL	1.45e-06	193	184	8	8f57b0473a2c2c07f83e5fe70f16862b1bb3b514
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM3 ABCA3 PTPN13 YAP1 TMPRSS2 TMC5 LRRC36 ACOXL	1.45e-06	193	184	8	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DENND5B MAGED1 RPN1 MANEA PKHD1L1 ENAM KLHL14 ACOXL	1.45e-06	193	184	8	38bb14df7f05c29565a1c7f175fafe636e543bf8
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	DENND5B MAGED1 RPN1 MANEA PKHD1L1 ENAM KLHL14 ACOXL	1.45e-06	193	184	8	3ba6d44248690b80f4caf791d463e60f1ab816c4
ToppCell	Fetal_29-31_weeks-Epithelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SHROOM3 ABCA3 PARD6B PTPN13 FGD4 TMPRSS2 TMC5 ACOXL	1.45e-06	193	184	8	a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCell	NS-critical-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TCN1 TMPRSS11B PARD6B EFNA1 PTPN13 RPTN TMPRSS2 TM4SF1	1.51e-06	194	184	8	614d0c25b56957c70f397abb169fd2a860eb1c06
ToppCell	normal_Lung-Epithelial_cells\|normal_Lung / Location, Cell class and cell subclass	SHROOM3 ABCA3 PARD6B EFNA1 PTPN13 TMPRSS2 TMC5 LRRC36	1.57e-06	195	184	8	7c90d887afde5c4d63352b5171be9987e2dfca58
ToppCell	mild-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TCF4 MANEA ZZEF1 ENAM ZNF860 BANK1 ACOXL INVS	1.57e-06	195	184	8	1e5f1967bcc898318f4e970b844b4a944eb168e5
ToppCell	mild-Plasmablast\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DENND5B TCF4 MANEA PKHD1L1 ENAM BRCA2 KLHL14 ACOXL	1.70e-06	197	184	8	21085d5e27b5a23a241a933058bb89f8a1fcf198
ToppCell	severe-Plasmablast\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DENND5B TCF4 MAGED1 MANEA PKHD1L1 ENAM KLHL14 ACOXL	1.76e-06	198	184	8	0b1620ad4352ee5d599a72931aaceab4ca407498
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LILRA1 P2RY13 CLEC7A CDH23 ITGB2 TLR8 STXBP2 VASP	1.76e-06	198	184	8	c00dbe61dc25602f19bd42a760646680002961ca
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 ABCA3 PTPN13 YAP1 TMPRSS2 TMC5 LRRC36 ACOXL	1.76e-06	198	184	8	f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell	severe-Plasmablast\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DENND5B TCF4 MAGED1 MANEA PKHD1L1 ENAM KLHL14 ACOXL	1.83e-06	199	184	8	6ee4c2e6049860071169366b7e662d5c1a3cc54b
ToppCell	Biopsy_Other_PF-Epithelial-AT2\|Biopsy_Other_PF / Sample group, Lineage and Cell type	SHROOM3 ABCA3 PARD6B PTPN13 TMPRSS2 TMC5 LRRC36 ACOXL	1.83e-06	199	184	8	9a65acfe9bf500db72142469cf17bf0973540001
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 ABCA3 PTPN13 FGD4 YAP1 TMPRSS2 TMC5 ACOXL	1.83e-06	199	184	8	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	Bronchial-10x5prime-Epithelial-Epi_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 ABCA3 PARD6B PTPN13 TMPRSS2 TMC5 LRRC36 ACOXL	1.83e-06	199	184	8	a38a981cffa61c8444a980916de7414e689a1b63
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LILRA1 P2RY13 CLEC7A CDH23 ITGB2 TLR8 STXBP2 VASP	1.83e-06	199	184	8	87c7b8c77c28f3cfa6d6dddfd00c9d18d116207e
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 ABCA3 PTPN13 FGD4 YAP1 TMPRSS2 TMC5 ACOXL	1.83e-06	199	184	8	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	Epithelial_cells\|World / lung cells shred on cell class, cell subclass, sample id	ABCA3 PARD6B EFNA1 PTPN13 YAP1 TMPRSS2 TMC5 TM4SF1	1.83e-06	199	184	8	bbe69e44b7970f57628365ae771790f2b13d0cae
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CCDC125 MGAM TCN1 P2RY13 STXBP2 FGD4 CPEB4 VASP	1.83e-06	199	184	8	b7af2b4fe6866cc8c78cf0f78390aab1b1b389ba
ToppCell	LPS-IL1RA-Myeloid-Monocytes,_Macrophages-Neutrophils\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LILRA1 EYS TIAM1 IL1A PLK3 BANK1 SMTNL2	1.85e-06	139	184	7	505bf5a483fc2ba69377db9850c3b26ab2f416d1
ToppCell	Biopsy_Other_PF-Epithelial-Transitional_AT2\|Biopsy_Other_PF / Sample group, Lineage and Cell type	SHROOM3 ABCA3 TEAD1 PARD6B EFNA1 TMPRSS2 TMC5 TM4SF1	1.90e-06	200	184	8	1ba6327851aa61e9a1f1fe1671bc27929d93ac74
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 ABCA3 PARD6B PTPN13 TMPRSS2 TMC5 LRRC36 ACOXL	1.90e-06	200	184	8	b2d61bc3afac0d78aa30082760da5b1a15d1fad2
ToppCell	Bronchial-10x5prime-Epithelial-Epi_alveolar-AT2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 ABCA3 PARD6B PTPN13 TMPRSS2 TMC5 LRRC36 ACOXL	1.90e-06	200	184	8	b535323e18d9fb0dde1e0026df142c831e48c29f
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_alveolar-AT2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 ABCA3 PARD6B PTPN13 TMPRSS2 TMC5 LRRC36 ACOXL	1.90e-06	200	184	8	23088edc62bf7d4db890937bfd7925dc316fcc76
ToppCell	Sepsis-Int-URO-Lymphocyte-B-B_intermediate\|Int-URO / Disease, condition lineage and cell class	DENND5B TCF4 NEB PKHD1L1 ARHGEF10 ZNF860 KLHL14 BANK1	1.90e-06	200	184	8	221dd8d8851c47f2202ba848de3a041b17b1db3f
ToppCell	PND01-03-samps\|World / Age Group, Lineage, Cell class and subclass	DENND5B RELN TCN1 TFAP2B ADGRL4 IL1A TM4SF1	4.90e-06	161	184	7	1973b112d8d67aacc02751797d0148e7b53bfa66
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-13\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TCF4 SHROOM3 PKHD1L1 HYLS1 ZNF860 KLHL14 BANK1	5.10e-06	162	184	7	28b3a6ae5519a267eefb70436d3190a387d027b9
ToppCell	control-Plasmablast\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DENND5B TCF4 NBEAL1 CCDC110 MANEA PKHD1L1 ENAM	5.75e-06	165	184	7	61063e0ce61bc92d5d1093be8279af03f650720b
ToppCell	CV-Mild-7\|Mild / Virus stimulation, Condition and Cluster	USP45 IARS1 FBXL3 NAA35 COG1 CPEB4 EDRF1	7.84e-06	173	184	7	c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|normal_Lymph_Node / Location, Cell class and cell subclass	PPP1R21 TCF4 LILRA1 TTLL5 ANKHD1 DST OSBPL11	8.77e-06	176	184	7	476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCell	TCGA-Kidney-Solid_Tissue_Normal-Kidney-Kidney_normal_tissue-3\|TCGA-Kidney / Sample_Type by Project: Shred V9	TFAP2B IGSF10 LGI2 GADL1 KLHL14 HSPA2	9.26e-06	117	184	6	9a780218d67fa2c0bcdedd22984c4f52bce4b80e
ToppCell	5'-Adult-LymphNode-Hematopoietic-Myeloid-Monocytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LILRA1 P2RY13 CLEC7A ITGB2 TLR8 STXBP2 SLC22A16	1.09e-05	182	184	7	1fb9bdf2e9f0a9c230f109b471672f9c31e27c82
ToppCell	COVID-19-Epithelial_cells-ECM-high_epithelial\|COVID-19 / group, cell type (main and fine annotations)	COL6A3 SHROOM3 ABCA3 YAP1 TMPRSS2 TMC5 TM4SF1	1.13e-05	183	184	7	dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCell	mild-B_cell\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TCF4 PKHD1L1 ENAM ZNF860 BANK1 ACOXL INVS	1.13e-05	183	184	7	175aaf8fbbff52eab87d78a49d5ab02cd489c438
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PALD1 TCF4 RELN SYNM PKHD1L1 DST KLHL14	1.13e-05	183	184	7	4d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCell	wk_08-11-Hematologic-Myeloid-DC3\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	LILRA1 P2RY13 CLEC7A ITGB2 TLR8 STXBP2 SLC22A16	1.17e-05	184	184	7	7d9294e5a55964903feda135e5bea0338824ed83
ToppCell	367C-Epithelial_cells-Epithelial-A_(AT2)\|367C / Donor, Lineage, Cell class and subclass (all cells)	SHROOM3 ABCA3 PTPN13 TMPRSS2 TMC5 LRRC36 ACOXL	1.17e-05	184	184	7	0ba243cbf69b4fe6ae100a7f0314317bec38026c
ToppCell	367C-Epithelial_cells-Epithelial-A_(AT2)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	SHROOM3 ABCA3 PTPN13 TMPRSS2 TMC5 LRRC36 ACOXL	1.17e-05	184	184	7	2a8338e94937686a148b5433515700ca0f674058
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	SHROOM3 PTPN13 TMPRSS2 RP1 RIMS1 TMC5 ACOXL	1.21e-05	185	184	7	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	IPF-Epithelial-ATII\|IPF / Disease state, Lineage and Cell class	SHROOM3 ABCA3 PARD6B PTPN13 YAP1 TMPRSS2 ACOXL	1.21e-05	185	184	7	563b4e6d92bb5d77a3829556116a8e99aebac615
ToppCell	15-Airway-Epithelial-Multiciliated_cell\|Airway / Age, Tissue, Lineage and Cell class	DNAH3 ATG9B RP1 C6 CFAP61 TMC5 DNAH11	1.21e-05	185	184	7	0998b6bf44287eebbf39249fff23fc3689e44c4e
ToppCell	mild-Lymphocytic-Plasmablast\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	DENND5B TCF4 MANEA PKHD1L1 ENAM KLHL14 ACOXL	1.26e-05	186	184	7	060510c21b1e0889b7a6eeb15821b9e2f03a0f99
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PALD1 TCF4 RELN SYNM PKHD1L1 DST KLHL14	1.26e-05	186	184	7	40070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCell	COVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi\|lung / Disease (COVID-19 only), tissue and cell type	DENND5B MANEA TSHR KIF20B ENAM CPEB4 KLHL14	1.26e-05	186	184	7	66676d9395172de5707e204826a1c9f73b448cca
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	CASP8AP2 NBEAL1 CEP350 ALMS1 CCSER2 OSBPL11 SPRTN	1.26e-05	186	184	7	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SHROOM3 ABCA3 PTPN13 FGD4 TMPRSS2 LRRC36 ACOXL	1.30e-05	187	184	7	5df9e1f5ca32217af255e76e6fb5afa346337811
ToppCell	mild_COVID-19-Plasmablast\|World / disease group, cell group and cell class (v2)	DENND5B MAGED1 TSHR PKHD1L1 ENAM KLHL14 ACOXL	1.35e-05	188	184	7	9a5ba6abdc307402301dae25db2a5f3e0d576417
ToppCell	(10)_B_cell\|World / immune cells in Peripheral Blood (logTPM normalization)	DENND5B TCF4 PKHD1L1 ZNF860 GNAO1 KLHL14 BANK1	1.35e-05	188	184	7	fa1346902021c3a6557555ada0fd37b29cf9d5ec
ToppCell	(1)_B_cell\|World / immune cells in Peripheral Blood (logTPM normalization)	DENND5B TCF4 PKHD1L1 ZNF860 GNAO1 KLHL14 BANK1	1.35e-05	188	184	7	642a334f2d5b6dc9df4a9fa0558833bd37bd3c58
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PALD1 RELN SYNM PKHD1L1 EYS KLHL14 TM4SF1	1.35e-05	188	184	7	2db80767903703e7e0a1a37c598f7877a909ee94
ToppCell	PBMC-Mild-Lymphocyte-B-Plasmablast-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DENND5B MANEA TSHR PKHD1L1 ENAM KLHL14 ACOXL	1.39e-05	189	184	7	73ee4cfb1057832f700be59b6917dedde3e89880
ToppCell	PBMC-Mild-Lymphocyte-B-Plasmablast-Plasmablast-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DENND5B MANEA TSHR PKHD1L1 ENAM KLHL14 ACOXL	1.39e-05	189	184	7	c296660061b46e3abae1e7cf29df20274e5a8add
Drug	prazosin hydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA	MAN1C1 CUL7 NEB ALMS1 IKBKE SNAI2 DIAPH1 TMPRSS2 PPIL2 HSD3B1	3.48e-06	194	180	10	942_UP
Drug	Metoclopramide monohydrochloride [7232-21-5]; Up 200; 11.8uM; HL60; HT_HG-U133A	DENND5B TCN1 TFDP3 NEB CEP350 DIAPH1 BICRAL TMC5 PLK3 ZNF124	4.00e-06	197	180	10	2353_UP
Disease	Disorder of eye	CDH23 PRPF8 MKS1 EYS ALMS1 RP1 RIMS1 STRA6 CNGA1 INVS	7.06e-07	212	178	10	C0015397
Disease	Paranoia	TCF4 MANEA TYK2	3.44e-05	11	178	3	C1456784
Disease	neutrophil percentage of leukocytes	CCDC125 PALD1 RPN1 CDH23 BEND3 LEPR ADGRL4 TYK2 TAF8 GNAO1 CFAP61 IL1A ACOXL	9.14e-05	610	178	13	EFO_0007990
Disease	myelodysplastic syndrome (implicated_via_orthology)	ATG7 PRPF8 SAMD9L	9.31e-05	15	178	3	DOID:0050908 (implicated_via_orthology)
Disease	RR interval, response to tetracyclic antidepressant, response to tricyclic antidepressant	ABCA3 BABAM2	1.08e-04	3	178	2	EFO_0004831, EFO_0007916, EFO_0007917
Disease	Charcot-Marie-Tooth disease	DCTN2 FGD4 MCM3AP DYNC1H1	1.20e-04	42	178	4	cv:C0007959
Disease	lymphocyte percentage of leukocytes	CCDC125 PALD1 RPN1 CDH23 BEND3 LEPR ADGRL4 TYK2 TAF8 IKBKE GNAO1 CFAP61 ACOXL	2.13e-04	665	178	13	EFO_0007993
Disease	response to carbamazepine	COL6A3 INTU	2.15e-04	4	178	2	EFO_0008484
Disease	Enterovirus Infections	MGAT5 COG1	5.34e-04	6	178	2	C0014378
Disease	congenital muscular dystrophy (implicated_via_orthology)	COL6A3 DYNC1H1	5.34e-04	6	178	2	DOID:0050557 (implicated_via_orthology)
Disease	Ciliopathies	CDH23 MKS1 HYLS1 INVS DNAH11	5.54e-04	110	178	5	C4277690
Disease	retinitis pigmentosa (implicated_via_orthology)	PRPF8 EYS CCDC66	5.68e-04	27	178	3	DOID:10584 (implicated_via_orthology)
Disease	respiratory failure, COVID-19	TYK2 DST CFAP61	7.03e-04	29	178	3	EFO_0009686, MONDO_0100096
Disease	atrioventricular septal defect (implicated_via_orthology)	MKS1 DNAH11	7.45e-04	7	178	2	DOID:0050651 (implicated_via_orthology)
Disease	proteinuria (implicated_via_orthology)	LEPR MGAT5 C6	7.77e-04	30	178	3	DOID:576 (implicated_via_orthology)
Disease	serum albumin measurement	SERPINA3 SHROOM3 BEND3 SIK3 ZZEF1 BABAM2 LEPR EIF2B4 CPEB4 GNAO1 BANK1	9.88e-04	592	178	11	EFO_0004535
Disease	Retinitis pigmentosa	PRPF8 EYS RP1 CNGA1	1.06e-03	74	178	4	cv:C0035334
Disease	hyperthyroidism	TSHR GNAO1 TAP2	1.23e-03	35	178	3	EFO_0009189
Disease	urticaria, response to non-steroidal anti-inflammatory, angioedema	RIMS1 BANK1	1.27e-03	9	178	2	EFO_0005531, EFO_0005532, EFO_0005533
Disease	threonine measurement	MANEA CPEB4 C6	1.44e-03	37	178	3	EFO_0009775
Disease	lymphoid leukemia	PALD1 GNAO1 ACOXL	1.56e-03	38	178	3	EFO_0004289
Disease	coffee consumption measurement, insomnia	TCF4 PROC	1.58e-03	10	178	2	EFO_0004698, EFO_0006781
Disease	cups of coffee per day measurement	EDC3 STRA6 ATP1A3	1.81e-03	40	178	3	EFO_0006782
Disease	neutrophil count	CCDC125 RPN1 NUP210L TTC39C CDH23 TSHR SIK3 TEAD1 CDC14A LEPR ADGRL4 LGI2 RP1 GNAO1 ATP1A3 IL1A TAP2 ACOXL	1.82e-03	1382	178	18	EFO_0004833
Disease	serum iron measurement	LEPR MGAT5 GNAO1 TMC5	1.85e-03	86	178	4	EFO_0006332
Disease	diffuse scleroderma (is_implicated_in)	TAP2 BANK1	1.92e-03	11	178	2	DOID:1580 (is_implicated_in)
Disease	Bipolar I disorder	SLC22A16 GADL1	1.92e-03	11	178	2	C0853193
Disease	Tumoral calcinosis	ITGB2 SNAI2 C6	2.08e-03	42	178	3	C0263628
Disease	Calcinosis	ITGB2 SNAI2 C6	2.08e-03	42	178	3	C0006663
Disease	Microcalcification	ITGB2 SNAI2 C6	2.08e-03	42	178	3	C0521174
Disease	neuroimaging measurement	TCF4 RELN SHROOM3 SZT2 NBEAL1 BEND3 KIF20B TYK2 ZNF462 CPEB4 GNAO1 TMC5 BANK1 PROC DNAH11	2.17e-03	1069	178	15	EFO_0004346
Disease	nervous system disease (implicated_via_orthology)	ATG7 ATP1A3	2.30e-03	12	178	2	DOID:863 (implicated_via_orthology)
Disease	chronic kidney disease (implicated_via_orthology)	SHROOM3 LEPR	2.30e-03	12	178	2	DOID:784 (implicated_via_orthology)
Disease	Neurodevelopmental Disorders	TCF4 KMT2C RIMS1 GNAO1	2.46e-03	93	178	4	C1535926
Disease	albuminuria	TCF4 SHROOM3 TSHR EFNA1	2.56e-03	94	178	4	EFO_0004285
Disease	rheumatoid arthritis, smoking status measurement, ACPA-positive rheumatoid arthritis	GNAO1 TAP2	2.70e-03	13	178	2	EFO_0000685, EFO_0006527, EFO_0009459
Disease	Bardet-Biedl Syndrome	MKS1 ALMS1	2.70e-03	13	178	2	C0752166
Disease	developmental and epileptic encephalopathy (implicated_via_orthology)	STXBP2 GNAO1	2.70e-03	13	178	2	DOID:0112202 (implicated_via_orthology)
Disease	bipolar disorder	ACTN3 ANKHD1 BABAM2 TFAP2B PCDHB16 ADGRL4 PARD6B BICRAL RIMS1 PROC	2.76e-03	577	178	10	MONDO_0004985
Disease	neuropathic pain	EYS STXBP2 SNAI2	2.88e-03	47	178	3	EFO_0005762
Disease	tetralogy of Fallot (implicated_via_orthology)	MKS1 INVS	3.14e-03	14	178	2	DOID:6419 (implicated_via_orthology)
Disease	insulin metabolic clearance rate measurement, glucose homeostasis measurement	ZZEF1 SLC22A16	3.14e-03	14	178	2	EFO_0006830, EFO_0006896
Disease	parental longevity	SHROOM3 BEND3 PARVB ADGRL4 CEP350 MGAT5 CCSER2 GNAO1 TAP2	3.21e-03	494	178	9	EFO_0007796
Disease	ocular hypertension, response to triamcinolone acetonide	CDH23 KIF20B CFAP61	3.24e-03	49	178	3	EFO_0006954, EFO_1001069
Disease	lymphocyte count	PALD1 TCF4 CDH23 BEND3 ITGB2 LEPR ADGRL4 TYK2 TAF8 PTPN12 CCDC66 ALMS1 IKBKE MCM3AP GNAO1 MORC3 KLHL14 ACOXL	3.36e-03	1464	178	18	EFO_0004587
Disease	acute graft vs. host disease, donor genotype effect measurement	AGGF1 EYS	3.61e-03	15	178	2	EFO_0004599, EFO_0007892
Disease	Churg-Strauss syndrome	GNAO1 ACOXL	3.61e-03	15	178	2	EFO_0007208
Disease	Retinitis Pigmentosa	PRPF8 EYS RP1 CNGA1	3.68e-03	104	178	4	C0035334
Disease	focal segmental glomerulosclerosis	IPO4 ALMS1	4.11e-03	16	178	2	EFO_0004236
Disease	Mental Depression	RELN GRIA3 RNF123 ARHGEF10 ATP1A3 IL1A	4.55e-03	254	178	6	C0011570
Disease	Dystonia, Limb	COL6A3 ATP1A3	4.64e-03	17	178	2	C0751093
Disease	Dystonia, Diurnal	COL6A3 ATP1A3	4.64e-03	17	178	2	C0393610
Disease	alcohol dependence	CDC14A MGAT5 PCNX1 GNAO1 ZNF124	5.16e-03	183	178	5	MONDO_0007079
Disease	C-X-C motif chemokine 16 measurement	CDH23 ACOXL	5.20e-03	18	178	2	EFO_0010911
Disease	Dystonia, Paroxysmal	COL6A3 ATP1A3	5.20e-03	18	178	2	C0393588
Disease	Meckel syndrome type 1	MKS1 HYLS1	5.20e-03	18	178	2	C3714506
Disease	IGA glomerulonephritis	GNAO1 TAP2 ACOXL	5.22e-03	58	178	3	EFO_0004194
Disease	response to efavirenz, virologic response measurement	MANEA IGSF10 TIAM1	5.22e-03	58	178	3	EFO_0006904, EFO_0006906
Disease	systemic lupus erythematosus, COVID-19	TYK2 GNAO1 TAP2	5.22e-03	58	178	3	MONDO_0007915, MONDO_0100096
Disease	non-melanoma skin carcinoma	ATG7 GRIA3 PARD6B BRCA2 GNAO1 TAP2	5.58e-03	265	178	6	EFO_0009260
Disease	Polydactyly	TFAP2B MKS1 ALMS1 HYLS1	5.59e-03	117	178	4	C0152427
Disease	Sjogren syndrome	RELN CPEB4 GNAO1	5.74e-03	60	178	3	EFO_0000699
Disease	Malignant neoplasm of breast	GABRP ABCA3 MANEA SIK3 LEPR LHCGR DAP3 EFNA1 BRCA2 PIK3CB YAP1 SNAI2 OSBPL11 LRRC7	5.75e-03	1074	178	14	C0006142
Disease	blood metabolite measurement	ALMS1 SLC22A16	5.78e-03	19	178	2	EFO_0005664
Disease	cancer (implicated_via_orthology)	PARVB ITGB2 DST BRCA2 PIK3CB YAP1	5.88e-03	268	178	6	DOID:162 (implicated_via_orthology)
Disease	HMG CoA reductase inhibitor use measurement	BRCA2 PCNX1 RP1 GNAO1 DNAH11	5.90e-03	189	178	5	EFO_0009932
Disease	Intellectual Disability	FBXL3 ZBTB24 ZNF462 KMT2C DIAPH1 ASTN1 STRA6 DYNC1H1	5.96e-03	447	178	8	C3714756

Protein segments in the cluster

Peptide	Gene	Start	Entry
QNPAFHHESRKTYGQ	BANK1	431	Q8NDB2
SSDNFLLKPQNYDNS	ADGRL4	311	Q9HBW9
SESQHSLKPNYLSQA	C2orf16	1061	Q68DN1
YLNNESQPDSFSTAH	ARHGEF10	906	O15013
REGKFQNPYAHSLTS	CFAP61	596	Q8NHU2
PHQSYDNLNYTLSKE	HSD3B1	261	P14060
FDPQDTHQSRFYLSK	SERPINA3	221	P01011
HLVYKINSNETQFPA	ADAM21	156	Q9UKJ8
NRPKSTVNTHYFSID	CDC14A	26	Q9UNH5
YTFSHPNNGDVSSKD	CDCP1	806	Q9H5V8
SHSEKSSVFYQQELP	ALMS1	956	Q8TCU4
QNERRHNYTTPKSFL	DNAH11	3061	Q96DT5
TVVNALFNNQAYHSP	ABCA3	1036	Q99758
YRQVDHFASNSQEPA	AGGF1	161	Q8N302
TYELHSRPEQDKFSQ	DCTN2	206	Q13561
KEKPNSAHRNSSASY	DIAPH1	61	O60610
VYNNSHKDVFLPNSA	CASP8AP2	881	Q9UKL3
DENDNHPLFTKSTYQ	CDH23	1951	Q9H251
YKDNIIATSPVDSNH	ASTN1	301	O14525
QYHSPIRNKSARFNA	ACOXL	216	Q9NUZ1
FPAKAVSEYLNRQHT	TFAP2B	331	Q92481
PNYNFKTHEEASALR	NBEAL1	1816	Q6ZS30
PTNLDKFNVSNFYHV	PPIL2	161	Q13356
DFVSYTPRDKQNLHE	PALD1	176	Q9ULE6
PINNDDNYHKAVSTA	PARD6B	71	Q9BYG5
PYFQNSSVEASHQSL	OOSP3	161	A0A2R8YFM6
NVYELFEKANASNSP	BEND3	151	Q5T5X7
EQPAFQYSSHVSLQA	POLDIP2	311	Q9Y2S7
SVAHPNLFIATKQDY	IL1A	236	P01583
QEPSTDYHFQQTGQS	PTCD3	201	Q96EY7
ETPSKAFHQYSNNIS	KMT2C	4271	Q8NEZ4
AFRNLPTKEQNFSHS	LHCGR	281	P22888
VYDFSQAHNAKDVPN	MAGED1	91	Q9Y5V3
YSEITHANDFKNNLP	EYS	1761	Q5T1H1
GTEPEFNHANYAQSK	MGAT5	381	Q09328
AHNPKNNTFTSVYHT	NRAP	56	Q86VF7
YHDSNPNRSLSNVFS	LRRC7	896	Q96NW7
QFSDLKSQNPEHYVQ	EDRF1	821	Q3B7T1
TSASVAPAQYQHQFA	HIPK1	1166	Q86Z02
PQVQYHNDKYISNTS	DST	2306	Q03001
FISEYAQDLSPNQSK	DST	3581	Q03001
ISQSTYKDPNNLAFN	MGAM	886	O43451
TISQSTYKDPNNLAF	MGAM	1781	O43451
KALASIYSPDHTNNS	TCF4	326	P15884
RHTPVCSFNSQNKYI	MCM3AP	976	O60318
KQTSVAPRHQEYLFE	IKBKE	341	Q14164
ISNTAKHFYGQRPQE	MAP3K8	91	P41279
QLYNTNQNTTEKPFH	GRIA3	56	P42263
TVPAYFNDSQRQATK	HSPA2	146	P54652
SPANNSHSRKAEVIY	PCNX1	2231	Q96RV3
QNATDSYVHKQYPAN	PLRG1	71	O43660
TTNANKYSPEFQQHL	FAT2	2471	Q9NYQ8
YATTHFNSDPAVLVN	LRRC36	401	Q1X8D7
FLKPTHNKQDFDYTN	MORC3	351	Q14149
RQSASSYFVHPSENL	CSNKA2IP	301	A0A1B0GTH6
SNFYNKSQSHPALER	CUL7	1426	Q14999
TQNEEYPHTFQVSGK	FGD4	481	Q96M96
PNTEANSFESKDYLQ	KIF20B	46	Q96Q89
NGHYETAVEPKFNSS	LEPR	61	P48357
SPQQQQCSKSYVDRH	EDC3	131	Q96F86
DTISPLNQKFSQYLH	PPP1R21	291	Q6ZMI0
LANVKSSEPVQYHSS	RALGAPA2	1336	Q2PPJ7
KVSLFSHLPQYSRQN	EIF2B4	176	Q9UI10
SYDPFASSEKIQQQV	IPMK	151	Q8NFU5
NLKVTFHIEPYSNRD	MANEA	216	Q5SRI9
QPSLQALHAYQESFT	SMPD4	346	Q9NXE4
PFQFHEATIYNSVNS	RELN	3171	P78509
QHQPKDFTQAQRVSY	RELN	3376	P78509
YLTPESFDQKVHNVS	PARVB	306	Q9HBI1
VPYTHSQTNNKTDCR	P2RY13	276	Q9BPV8
SPRLHQQFESYKEQV	RIMS1	81	Q86UR5
AKLHSSASPSAQQYD	INTU	446	Q9ULD6
FVHPNYSKSTTDNDI	PROC	286	P04070
NVQNYKISPSSHFRV	PCDHB16	166	Q9NRJ7
SNEFDYPSVGQLAHK	ITGB2	296	P05107
SHSFNRAVDLTKPYQ	CCSER2	241	Q9H7U1
DFESHITSYKQNPEQ	EIF3C	151	Q99613
DFESHITSYKQNPEQ	EIF3CL	151	B5ME19
LYTKHNPQEQFSENN	CEFIP	411	Q711Q0
HKVNASYPRVSSTNE	IGSF10	1156	Q6WRI0
SQKFNLPHEYQGISQ	HYLS1	151	Q96M11
NGKHSTNFVSRYDPR	KLHL14	386	Q9P2G3
HITFVDNAKISYSNP	ATG7	381	O95352
YFLHGPSNKSSNDDL	BICRAL	21	Q6AI39
YSKHKSQQDTFPQVS	CCDC125	76	Q86Z20
TSNSPSNKHIHFEYN	COG1	456	Q8WTW3
DQPTLTFQSVYHFTN	BABAM2	321	Q9NXR7
FPHDTTANVKSYFSN	BRCA2	221	P51587
LFSKQDFNSNHNLTP	BRCA2	1091	P51587
NHSIKVSPYLSQFQQ	BRCA2	2146	P51587
VPIFYSSKRSENINH	C6	281	P13671
HFAPKSNYDSSRNIE	DNAH3	421	Q8TD57
NSSNPKFRNEDYTIH	EFNA1	26	P20827
FELNQPATSYLKATH	FBXL3	81	Q9UKT7
IEHYFSPVSKEQQNN	FAM111A	21	Q96PZ2
NPHTEFLLNTYRTKQ	COL6A3	86	P12111
EKVHVDFNSYVQSPA	GCM1	366	Q9NP62
VRFEFHYPNSDQAQK	CC2D1B	726	Q5T0F9
HFDSLKSYPGSQSQL	CCDC66	366	A2RUB6
TLSPQEDHSNRKSAY	CEP350	1131	Q5VT06
LSFRTQTDNKDPQFH	DENND5B	86	Q6ZUT9
NVEASHPSQDGKRQY	APBA1	571	Q02410
VDYNVLFANQPSNHT	ATG9B	236	Q674R7
QDVYSSTPNHDNKQQ	MAN1C1	566	Q9NR34
PFNSTNKYQLSIHET	ATP1A3	471	P13637
ALREHSNPNYDKTSA	DYNC1H1	1981	Q14204
NHVQADFYRKNDIPS	C5orf49	121	A4QMS7
NHIQLQKYARPSSAF	CPEB4	341	Q17RY0
SETNQSELKHSSYQP	ENAM	531	Q9NRM1
IHYSVKTNHPRFFNQ	GADL1	106	Q6ZQY3
LAHPQNYFKYTAQES	SCUBE2	961	Q9NQ36
FSENLQPHISSYSRE	IPO4	421	Q8TEX9
FTIQNPSNVDHYSKL	GABRP	406	O00591
NATIYNHPDVKETFS	NUP210L	906	Q5VU65
ATYSSSQDHQTPKQE	PTPN13	1326	Q12923
SLSNHYKNGADQPFA	OSBPL11	301	Q9BXB4
TPLHYAAQSNFAETV	INVS	291	Q9Y283
TDPEYKNGFNTLVSH	RP1	1376	P56715
SSYNKQRFDQPLEAS	DAP3	171	P51398
DEVLYKSSQDFQPRH	RARS2	506	Q5T160
KSSQDFQPRHIVSYL	RARS2	511	Q5T160
RSGSKQSTNPADNYH	TAF8	16	Q7Z7C8
SPKYTDSNSRNHFQH	SZT2	2251	Q5T011
NTVANEVYKYNFPHT	TRDMT1	36	O14717
QKAPLASFNHSSALY	SYNM	361	O15061
SQNKTASHPQDYTVE	LILRA1	446	O75019
FNSKNDVYVAIAQPS	LGI2	236	Q8N0V4
YGPQTKEVNEQTHFA	NKRF	76	O15226
SYNKLNSKSPESDNH	SAMD9L	71	Q8IVG5
NSPTEVQKHNLSYLF	SLC22A16	336	Q86VW1
AAYIQAQFESKNRSP	GNAO1	301	P09471
QFAETPKENHSNYRT	SLITRK3	796	O94933
TPSQDSDYINANFIK	PTPN12	81	Q05209
FNASKKPNYSELDTH	SNAI2	11	O43623
DHFQSVASQSYRPLE	PPP1R32	81	Q7Z5V6
QDTFKVHYENNSPFL	RPN1	211	P04843
EAHSLNVNRFSPANY	SIK3	871	Q9Y2K2
SSAPDFANLKHYQKQ	SHROOM3	1446	Q8TF72
PFTIAAEKVYNTRHQ	TAP2	301	Q03519
NTPLSNFESHQNYKD	IARS1	186	P41252
NFESHQNYKDVQDPS	IARS1	191	P41252
TNPYTENATALHVKF	PIK3CB	481	P42338
NEFKQIAYNHPSSSI	NOX3	516	Q9HBY0
YRNFLKIEVSQSHPA	STRA6	566	Q9BX79
KTAPYRNVNVQNFHT	ACTN3	171	Q08043
HPSENSDILKNYNNF	CCDC110	186	Q8TBZ0
ANKEHRNVSDYTPLS	ANKHD1	1146	Q8IWZ3
NGYFLSRNKENHSQP	CLEC7A	81	Q9BXN2
SENENPHARGSFSYK	CNGA1	51	P29973
ENSFVSVYSKDNPNL	PRPF8	1171	Q6P2Q9
ALSANRKTVHYNPTS	PLK3	496	Q9H4B4
GSYPQHINISRNFSK	TLR8	351	Q9NR97
YLTHSDTARIQQAFP	TRMO	231	Q9BU70
VISHPNYDSKTKNND	TMPRSS2	331	O15393
EGKHLRSYSPQNAFQ	USP45	591	Q70EL2
VSPNRQAHSKYGQFL	TRPM6	1331	Q9BX84
AQNPKQQHSSTLESY	TIAM1	1171	Q13009
QRITSSNFLHYQPAA	MKS1	31	Q9NXB0
QSPELYVAASKHFQQ	NAA35	651	Q5VZE5
RKVQNIIFHENYSSP	TMPRSS11B	251	Q86T26
NDYLNRIFSSSEHAP	RNF123	36	Q5XPI4
AVAAAYTFLQRNPKH	P3H4	161	Q92791
NQSSSPKNHQENYFL	ZNF267	226	Q14586
EAQVFSLDAPHSTYN	STXBP2	141	Q15833
FLHYPDSAAAQQAVS	MTHFSD	346	Q2M296
YSTAEVVNHFTPENK	TCN1	161	P20061
KTSSGQRYFLNHIDQ	YAP1	181	P46937
DAFDYNSLSPTQRQK	SMTNL2	396	Q2TAL5
HQFPNYSSELNVNAL	TRBV5-7	86	A0A0A0MS05
SAKFVDVQYSHTPNK	PKHD1L1	2771	Q86WI1
DNTRYSPNDLQKHFQ	ZNF518A	126	Q6AHZ1
SSNQGSLPFHNYSKV	ZNF518A	631	Q6AHZ1
NHASPNESAYDVKNI	TFDP3	146	Q5H9I0
PNGETKYASENHLSR	TM4SF1	31	P30408
SNSHQNVLSNYFPRV	SPRTN	321	Q9H040
HQFPNYSSELNVNAL	TRBV5-6	86	A0A599
SFQIHQRNHTGEKPY	ZNF124	136	Q15973
LVKAYTDFQNNHSSP	ZBTB24	121	O43167
STDQYDQRHAGNKPI	ZNF888	121	P0CJ79
VRESKHPYNNNTNFE	ZZEF1	2701	O43149
EPNFRNITHDYNATN	ZNF462	771	Q96JM2
LYSQHPSFQTQQAKL	ZNF687	811	Q8N1G0
KNLEHTSFRINPYAD	TMC5	186	Q6UXY8
SSRPKIHISNNYENN	ZNF860	196	A6NHJ4
EQQRDPDSYNKHLFV	TEAD1	226	P28347
RESDQLFKQYRNHSP	TTC39C	46	Q8N584
TDRQGQSSHYSQPDK	RPTN	466	Q6XPR3
NYFTKPNLKHTDTAN	ZFC3H1	1051	O60293
RNAINYHQDLSQPSF	ZNF248	196	Q8NDW4
FQSAAHIYSQKLSRP	TTLL5	976	Q6EMB2
LAEKQAARQYSPSSH	TTLL5	1036	Q6EMB2
ANKNFPYHVRTSQIA	TMEM145	406	Q8NBT3
QSADKAFPQHVYGNV	TMEM145	431	Q8NBT3
QSRSPSEKEHFYQRQ	TYK2	816	P29597
KNPQEETLQAFDSHY	TSHR	371	P16473
QAFSRVQIYHNPTAN	VASP	31	P50552
GHFTLAYSAKPQAAN	ART3	181	Q13508
YTANSPLHKEFNAAV	ART1	121	P52961
ADSPINRHFKYATQL	NEB	5386	P20929